TMCO5A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)9.43904225
2sperm capacitation (GO:0048240)7.78114172
3spermatid development (GO:0007286)7.46219970
4plasma membrane fusion (GO:0045026)7.36770144
5multicellular organism reproduction (GO:0032504)6.98866480
6leukotriene biosynthetic process (GO:0019370)6.84826493
7response to pheromone (GO:0019236)6.83364511
8single strand break repair (GO:0000012)6.80237128
9phosphatidylethanolamine biosynthetic process (GO:0006646)6.76598262
10protein targeting to Golgi (GO:0000042)6.68644785
11establishment of protein localization to Golgi (GO:0072600)6.66105577
12DNA packaging (GO:0006323)6.63705526
13sperm-egg recognition (GO:0035036)6.58694114
14chromosome condensation (GO:0030261)6.51722416
15axonemal dynein complex assembly (GO:0070286)6.41211337
16phosphatidylethanolamine metabolic process (GO:0046337)6.36701932
17retrograde transport, vesicle recycling within Golgi (GO:0000301)6.23794167
18reproduction (GO:0000003)6.23551357
19cilium or flagellum-dependent cell motility (GO:0001539)6.19472018
20spermatid nucleus differentiation (GO:0007289)6.10113352
21rRNA methylation (GO:0031167)6.09600420
22microtubule depolymerization (GO:0007019)6.08232406
23protein polyglutamylation (GO:0018095)5.96290943
24microtubule severing (GO:0051013)5.78804939
25binding of sperm to zona pellucida (GO:0007339)5.54941484
26cell-cell recognition (GO:0009988)5.52348420
27calcium ion-dependent exocytosis (GO:0017156)5.44220793
28cellular ketone body metabolic process (GO:0046950)5.40695748
29negative regulation of inclusion body assembly (GO:0090084)5.38868495
30epithelial cilium movement (GO:0003351)5.28861559
31microtubule polymerization or depolymerization (GO:0031109)5.23374185
32spermatogenesis (GO:0007283)5.22564486
33male gamete generation (GO:0048232)5.20783139
34regulation of cilium movement (GO:0003352)5.16747905
35sexual reproduction (GO:0019953)5.05823249
36rRNA modification (GO:0000154)4.91684992
37gamete generation (GO:0007276)4.77532987
38ketone body metabolic process (GO:1902224)4.76203012
39protein localization to Golgi apparatus (GO:0034067)4.75620767
40centriole replication (GO:0007099)4.72437881
41cilium movement (GO:0003341)4.68663590
42regulation of Rab GTPase activity (GO:0032313)4.67571465
43positive regulation of Rab GTPase activity (GO:0032851)4.67571465
44single fertilization (GO:0007338)4.60715347
45motile cilium assembly (GO:0044458)4.52152538
46leukotriene metabolic process (GO:0006691)4.46428359
47peptide catabolic process (GO:0043171)4.38246206
48cell wall macromolecule catabolic process (GO:0016998)4.26013437
49cell wall macromolecule metabolic process (GO:0044036)4.19684412
50germ cell development (GO:0007281)4.18631288
51centriole assembly (GO:0098534)4.16801597
52epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.02917575
53regulation of transcription involved in cell fate commitment (GO:0060850)3.97053691
54coenzyme catabolic process (GO:0009109)3.96972963
55cysteine metabolic process (GO:0006534)3.91944683
56cellular process involved in reproduction in multicellular organism (GO:0022412)3.87424320
57glutathione metabolic process (GO:0006749)3.84147919
58response to acidic pH (GO:0010447)3.83762258
59regulation of microtubule-based movement (GO:0060632)3.83244666
60multicellular organismal reproductive process (GO:0048609)3.81262459
61musculoskeletal movement (GO:0050881)3.71382293
62multicellular organismal movement (GO:0050879)3.71382293
63organic cation transport (GO:0015695)3.70334518
64fertilization (GO:0009566)3.67908411
65somite rostral/caudal axis specification (GO:0032525)3.65814739
66regulation of inclusion body assembly (GO:0090083)3.58153029
67icosanoid biosynthetic process (GO:0046456)3.49844392
68fatty acid derivative biosynthetic process (GO:1901570)3.49844392
69Golgi to endosome transport (GO:0006895)3.44428720
70peptidyl-threonine dephosphorylation (GO:0035970)3.42709056
71RNA destabilization (GO:0050779)3.41113122
72NAD biosynthetic process (GO:0009435)3.37514745
73chromatin silencing (GO:0006342)3.31473937
74antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20912609
75seminiferous tubule development (GO:0072520)3.16578297
76negative regulation of cAMP-mediated signaling (GO:0043951)3.15503983
77polyamine biosynthetic process (GO:0006596)3.11931841
78cofactor catabolic process (GO:0051187)3.06732579
79alanine transport (GO:0032328)3.06317964
80negative regulation of Rho protein signal transduction (GO:0035024)3.04113825
81unsaturated fatty acid biosynthetic process (GO:0006636)3.01453136
82regulation of establishment of cell polarity (GO:2000114)2.98158575
83intra-Golgi vesicle-mediated transport (GO:0006891)2.93898133
84nucleus organization (GO:0006997)2.93881910
85histone H3-K9 demethylation (GO:0033169)2.90312913
86regulation of somitogenesis (GO:0014807)2.89342825
87regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.86509364
88regulation of T-helper 2 cell differentiation (GO:0045628)2.83206132
89multicellular organismal development (GO:0007275)2.79525253
90male meiosis I (GO:0007141)2.79504417
91cell recognition (GO:0008037)2.75706050
92mesenchymal cell differentiation involved in renal system development (GO:2001012)2.74823329
93mesenchymal cell differentiation involved in kidney development (GO:0072161)2.74823329
94positive regulation of guanylate cyclase activity (GO:0031284)2.72508954
95axoneme assembly (GO:0035082)2.71360101
96pattern specification involved in kidney development (GO:0061004)2.70271315
97cilium assembly (GO:0042384)2.69105586
98cilium organization (GO:0044782)2.68892248
99sperm motility (GO:0030317)10.4467134
100acrosome reaction (GO:0007340)10.2341319

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.56310627
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.74746893
3EZH2_22144423_ChIP-Seq_EOC_Human2.71261665
4CTBP2_25329375_ChIP-Seq_LNCAP_Human2.53540418
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.30562097
6TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.30562097
7CTBP1_25329375_ChIP-Seq_LNCAP_Human2.25627063
8GBX2_23144817_ChIP-Seq_PC3_Human2.11917978
9TAF15_26573619_Chip-Seq_HEK293_Human2.08051037
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.03424352
11* IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.00274569
12* CBP_20019798_ChIP-Seq_JUKART_Human2.00274569
13DROSHA_22980978_ChIP-Seq_HELA_Human1.93634529
14FUS_26573619_Chip-Seq_HEK293_Human1.89808719
15ER_23166858_ChIP-Seq_MCF-7_Human1.87811952
16MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.75549474
17SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.73875161
18* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.72608872
19EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69578571
20SMAD3_21741376_ChIP-Seq_EPCs_Human1.68317763
21VDR_22108803_ChIP-Seq_LS180_Human1.65554219
22ARNT_22903824_ChIP-Seq_MCF-7_Human1.64845633
23SMAD4_21741376_ChIP-Seq_EPCs_Human1.64529927
24* P300_19829295_ChIP-Seq_ESCs_Human1.63785440
25AR_25329375_ChIP-Seq_VCAP_Human1.54004347
26AR_21572438_ChIP-Seq_LNCaP_Human1.52623896
27EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.52379613
28* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.49058254
29* SMAD4_21799915_ChIP-Seq_A2780_Human1.42659062
30NANOG_20526341_ChIP-Seq_ESCs_Human1.40741623
31EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40231289
32STAT3_23295773_ChIP-Seq_U87_Human1.39750631
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36741108
34ZNF274_21170338_ChIP-Seq_K562_Hela1.34717561
35* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34630961
36TAF2_19829295_ChIP-Seq_ESCs_Human1.32712871
37RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.32529724
38OCT4_20526341_ChIP-Seq_ESCs_Human1.30752669
39EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.30548452
40TP53_18474530_ChIP-ChIP_U2OS_Human1.29968207
41SOX2_19829295_ChIP-Seq_ESCs_Human1.29409069
42NANOG_19829295_ChIP-Seq_ESCs_Human1.29409069
43WDR5_24793694_ChIP-Seq_LNCAP_Human1.29256374
44ETV1_20927104_ChIP-Seq_GIST48_Human1.28698728
45GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28493548
46RAC3_21632823_ChIP-Seq_H3396_Human1.27933028
47* ETV2_25802403_ChIP-Seq_MESCs_Mouse1.27928618
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.27163831
49RBPJ_21746931_ChIP-Seq_IB4_Human1.26831706
50* RUNX2_22187159_ChIP-Seq_PCA_Human1.26101643
51* SMAD3_21741376_ChIP-Seq_ESCs_Human1.25714871
52ERA_21632823_ChIP-Seq_H3396_Human1.25173623
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23419997
54OCT1_27270436_Chip-Seq_PROSTATE_Human1.23377304
55MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.23200978
56* SMRT_27268052_Chip-Seq_Bcells_Human1.23024246
57MYC_19829295_ChIP-Seq_ESCs_Human1.22450436
58POU3F2_20337985_ChIP-ChIP_501MEL_Human1.21782411
59CBX2_22325352_ChIP-Seq_293T-Rex_Human1.21756058
60* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.20481179
61HNFA_21074721_ChIP-Seq_CACO-2_Human1.19307900
62CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.18758540
63RXR_22108803_ChIP-Seq_LS180_Human1.18457609
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.18145013
65* TBL1_22424771_ChIP-Seq_293T_Human1.16806860
66NFYB_21822215_ChIP-Seq_K562_Human1.16292523
67TDRD3_21172665_ChIP-Seq_MCF-7_Human1.16204858
68* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15747141
69* PRDM14_20953172_ChIP-Seq_ESCs_Human1.15475531
70ERG_20517297_ChIP-Seq_VCAP_Human1.15447777
71PHF8_20622853_ChIP-Seq_HELA_Human1.14694532
72AUTS2_25519132_ChIP-Seq_293T-REX_Human1.14157366
73CEBPB_22108803_ChIP-Seq_LS180_Human1.14060015
74TCF4_23295773_ChIP-Seq_U87_Human1.11710142
75SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11224634
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10333209
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.08232137
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.08056398
79VDR_24787735_ChIP-Seq_THP-1_Human1.06909697
80KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.06727373
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06397891
82CDX2_22108803_ChIP-Seq_LS180_Human1.06261457
83HOXB7_26014856_ChIP-Seq_BT474_Human1.06253505
84CTCF_27219007_Chip-Seq_Bcells_Human1.05847162
85PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.05446602
86REST_21632747_ChIP-Seq_MESCs_Mouse1.05303218
87KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04176446
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.03049539
89RUNX_20019798_ChIP-Seq_JUKART_Human1.02880773
90CJUN_26792858_Chip-Seq_BT549_Human1.02790135
91NFYA_21822215_ChIP-Seq_K562_Human1.02683144
92GATA6_21074721_ChIP-Seq_CACO-2_Human1.01399620
93P53_21459846_ChIP-Seq_SAOS-2_Human1.00873837
94KDM2B_26808549_Chip-Seq_REH_Human1.00442302
95SMAD4_21741376_ChIP-Seq_HESCs_Human1.00428110
96TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human1.00214453
97NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99794399
98YY1_22570637_ChIP-Seq_MALME-3M_Human0.98636319
99SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98082357
100GATA3_26560356_Chip-Seq_TH1_Human0.97440645

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.20912712
2MP0003878_abnormal_ear_physiology5.20912712
3MP0003698_abnormal_male_reproductive3.88816274
4MP0005670_abnormal_white_adipose3.86247830
5MP0001929_abnormal_gametogenesis3.31069584
6MP0005379_endocrine/exocrine_gland_phen3.18479323
7MP0003183_abnormal_peptide_metabolism2.35677745
8MP0000569_abnormal_digit_pigmentation2.32317645
9MP0002161_abnormal_fertility/fecundity2.07798899
10MP0001968_abnormal_touch/_nociception2.00456706
11MP0001348_abnormal_lacrimal_gland2.00449168
12MP0005410_abnormal_fertilization10.2562920
13MP0002163_abnormal_gland_morphology1.97727851
14MP0001485_abnormal_pinna_reflex1.95353168
15MP0002822_catalepsy1.71805576
16MP0005551_abnormal_eye_electrophysiolog1.70206229
17MP0003646_muscle_fatigue1.67365768
18MP0002736_abnormal_nociception_after1.54811418
19MP0002132_abnormal_respiratory_system1.53472155
20MP0003879_abnormal_hair_cell1.52016633
21MP0002210_abnormal_sex_determination1.48299066
22MP0001486_abnormal_startle_reflex1.44139879
23MP0002735_abnormal_chemical_nociception1.43836618
24MP0001765_abnormal_ion_homeostasis1.40701382
25MP0004742_abnormal_vestibular_system1.39204993
26MP0000613_abnormal_salivary_gland1.36456761
27MP0002102_abnormal_ear_morphology1.34343684
28MP0008877_abnormal_DNA_methylation1.34298902
29MP0000653_abnormal_sex_gland1.33592563
30MP0003011_delayed_dark_adaptation1.33318398
31MP0001145_abnormal_male_reproductive1.30158373
32MP0005310_abnormal_salivary_gland1.28206016
33MP0000678_abnormal_parathyroid_gland1.27840031
34MP0001963_abnormal_hearing_physiology1.27440822
35MP0002229_neurodegeneration1.26988972
36MP0000026_abnormal_inner_ear1.26862328
37MP0003718_maternal_effect1.26283969
38MP0002837_dystrophic_cardiac_calcinosis1.24633117
39MP0004019_abnormal_vitamin_homeostasis1.22968778
40MP0002067_abnormal_sensory_capabilities1.20071370
41MP0005423_abnormal_somatic_nervous1.16873688
42MP0002653_abnormal_ependyma_morphology1.14780665
43MP0003195_calcinosis1.04892098
44MP0002138_abnormal_hepatobiliary_system1.03985332
45MP0001501_abnormal_sleep_pattern1.03083764
46MP0005253_abnormal_eye_physiology1.02402544
47MP0000534_abnormal_ureter_morphology1.01708020
48MP0005666_abnormal_adipose_tissue1.01641134
49MP0001440_abnormal_grooming_behavior1.01527261
50MP0003959_abnormal_lean_body0.98935954
51MP0002272_abnormal_nervous_system0.95016014
52MP0008569_lethality_at_weaning0.92953141
53MP0005395_other_phenotype0.91494495
54MP0002234_abnormal_pharynx_morphology0.91149236
55MP0002733_abnormal_thermal_nociception0.88647988
56MP0008961_abnormal_basal_metabolism0.88500684
57MP0009053_abnormal_anal_canal0.86861675
58MP0004484_altered_response_of0.85734835
59MP0009046_muscle_twitch0.85252676
60MP0008872_abnormal_physiological_respon0.84763624
61MP0009115_abnormal_fat_cell0.84428159
62MP0001984_abnormal_olfaction0.83757567
63MP0000230_abnormal_systemic_arterial0.83031758
64MP0002127_abnormal_cardiovascular_syste0.82857273
65MP0001970_abnormal_pain_threshold0.82254699
66MP0010386_abnormal_urinary_bladder0.81934192
67MP0001756_abnormal_urination0.81407598
68MP0002572_abnormal_emotion/affect_behav0.78898367
69MP0009745_abnormal_behavioral_response0.77736578
70MP0002557_abnormal_social/conspecific_i0.77728127
71MP0000371_diluted_coat_color0.74972332
72MP0002168_other_aberrant_phenotype0.73433631
73MP0003136_yellow_coat_color0.71912051
74MP0008995_early_reproductive_senescence0.71104969
75MP0005375_adipose_tissue_phenotype0.70997624
76MP0004859_abnormal_synaptic_plasticity0.67634490
77MP0003631_nervous_system_phenotype0.63607908
78MP0001905_abnormal_dopamine_level0.62749916
79MP0005248_abnormal_Harderian_gland0.61829889
80MP0005367_renal/urinary_system_phenotyp0.61806304
81MP0000516_abnormal_urinary_system0.61806304
82MP0003632_abnormal_nervous_system0.61020256
83MP0005332_abnormal_amino_acid0.60997339
84MP0000955_abnormal_spinal_cord0.60969920
85MP0003045_fibrosis0.60800410
86MP0002282_abnormal_trachea_morphology0.60408812
87MP0009697_abnormal_copulation0.58550236
88MP0005266_abnormal_metabolism0.57448264
89MP0004510_myositis0.56048584
90MP0004085_abnormal_heartbeat0.55462465
91MP0000049_abnormal_middle_ear0.54584165
92MP0002752_abnormal_somatic_nervous0.53575336
93MP0003633_abnormal_nervous_system0.52730910
94MP0005085_abnormal_gallbladder_physiolo0.52695182
95MP0001666_abnormal_nutrient_absorption0.52122959
96MP0004215_abnormal_myocardial_fiber0.51593727
97MP0005647_abnormal_sex_gland0.51421070
98MP0002249_abnormal_larynx_morphology0.50914610
99MP0000470_abnormal_stomach_morphology0.50071781
100MP0002115_abnormal_skeleton_extremities0.48675074

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)7.28827834
2Absent/shortened dynein arms (HP:0200106)6.45183532
3Dynein arm defect of respiratory motile cilia (HP:0012255)6.45183532
4Abnormal ciliary motility (HP:0012262)5.41714288
5Abnormal respiratory epithelium morphology (HP:0012253)5.11088818
6Abnormal respiratory motile cilium morphology (HP:0005938)5.11088818
7Abnormal respiratory motile cilium physiology (HP:0012261)4.98419442
8Attenuation of retinal blood vessels (HP:0007843)4.76491521
9Abnormal rod and cone electroretinograms (HP:0008323)4.60113070
10Bony spicule pigmentary retinopathy (HP:0007737)4.45435265
11Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.21392537
12Hyperkalemia (HP:0002153)4.13336269
13Tubulointerstitial nephritis (HP:0001970)4.01873773
14Chronic hepatic failure (HP:0100626)3.86662058
15Abnormality of macular pigmentation (HP:0008002)3.80898982
16Asymmetric septal hypertrophy (HP:0001670)3.76712432
17Infertility (HP:0000789)3.48608855
18Potter facies (HP:0002009)3.46875242
19Facial shape deformation (HP:0011334)3.46875242
20Nasal polyposis (HP:0100582)3.42864294
21Nephronophthisis (HP:0000090)3.34238789
22Bell-shaped thorax (HP:0001591)3.26547905
23Hypoplastic ischia (HP:0003175)3.22849914
24Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.17454738
25Hypoplasia of the thymus (HP:0000778)3.14596729
26Male infertility (HP:0003251)3.12668861
27Rhinitis (HP:0012384)3.07555528
28Postural instability (HP:0002172)3.01399321
29Pancreatic fibrosis (HP:0100732)2.95487281
30Cone-rod dystrophy (HP:0000548)2.91003096
31Abnormality of the ischium (HP:0003174)2.87758876
32Aplasia/Hypoplasia of the earlobes (HP:0009906)2.86708186
33Genetic anticipation (HP:0003743)2.83551366
34Abnormality of the renal medulla (HP:0100957)2.80806722
35Nonprogressive disorder (HP:0003680)2.79700006
36Progressive cerebellar ataxia (HP:0002073)2.77080602
37Enlarged epiphyses (HP:0010580)2.65974736
38Bronchiectasis (HP:0002110)2.64553702
39Abnormality of the nasal mucosa (HP:0000433)2.62309404
40Resting tremor (HP:0002322)2.61403532
41Pancreatic cysts (HP:0001737)2.60058514
42Abnormality of potassium homeostasis (HP:0011042)2.59195193
43Truncal obesity (HP:0001956)2.51224754
44Abnormal spermatogenesis (HP:0008669)2.46156984
45Unilateral renal agenesis (HP:0000122)2.42881812
46Tubulointerstitial abnormality (HP:0001969)2.38162502
47True hermaphroditism (HP:0010459)2.35216863
48Abnormal urine output (HP:0012590)2.33646942
49Congenital stationary night blindness (HP:0007642)2.31501018
50Recurrent pneumonia (HP:0006532)2.30134278
51Vertebral arch anomaly (HP:0008438)2.30106934
52Portal hypertension (HP:0001409)2.29616658
53Protuberant abdomen (HP:0001538)2.29286850
54Amelogenesis imperfecta (HP:0000705)2.28696031
55Polydipsia (HP:0001959)2.27529478
56Abnormal drinking behavior (HP:0030082)2.27529478
57Azoospermia (HP:0000027)2.26988065
58Congenital sensorineural hearing impairment (HP:0008527)2.26477938
59Carpal bone hypoplasia (HP:0001498)2.25883158
60Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.23254296
61Broad alveolar ridges (HP:0000187)2.22410358
62Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20316715
63Impulsivity (HP:0100710)2.17235434
64Cystic liver disease (HP:0006706)2.15756937
65Slow saccadic eye movements (HP:0000514)2.11491425
66Abnormality of the hepatic vasculature (HP:0006707)2.09744517
67Aplasia/Hypoplasia of the fovea (HP:0008060)2.08441646
68Hypoplasia of the fovea (HP:0007750)2.08441646
69Abnormality of renal excretion (HP:0011036)2.04777898
70Decreased central vision (HP:0007663)2.03388025
71Abnormality of the parathyroid morphology (HP:0011766)2.03198573
72Osteomalacia (HP:0002749)2.02269974
73Abnormality of dental color (HP:0011073)1.99005724
74Polyuria (HP:0000103)1.98793439
75Chronic bronchitis (HP:0004469)1.98755858
76Stage 5 chronic kidney disease (HP:0003774)1.98577795
77Renal dysplasia (HP:0000110)1.96153855
78Hypoalphalipoproteinemia (HP:0003233)1.94680344
79Scotoma (HP:0000575)1.91620743
80Hypophosphatemic rickets (HP:0004912)1.87287481
81Tubular atrophy (HP:0000092)1.87062274
82Mixed hearing impairment (HP:0000410)1.84286295
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83074761
84Anencephaly (HP:0002323)1.82912200
85Short ribs (HP:0000773)1.82579497
86Photophobia (HP:0000613)1.82018092
87Bronchitis (HP:0012387)1.81707236
88Thoracolumbar scoliosis (HP:0002944)1.79458788
89Congenital hepatic fibrosis (HP:0002612)1.77741115
90Hypokalemia (HP:0002900)1.77310864
91Insulin-resistant diabetes mellitus (HP:0000831)1.74617975
92Menstrual irregularities (HP:0000858)1.74548866
93Macular degeneration (HP:0000608)1.74042981
94Abnormality of chloride homeostasis (HP:0011422)1.73147916
95Recurrent bronchitis (HP:0002837)1.69986309
96Deformed sella turcica (HP:0002681)1.69679009
97Type 2 muscle fiber atrophy (HP:0003554)1.68078095
98Abnormality of the fovea (HP:0000493)1.66387329
99Fatigable weakness (HP:0003473)1.63885052
100Abnormality of the neuromuscular junction (HP:0003398)1.63885052

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK45.75438599
2TESK14.29865000
3FRK4.23545622
4STK383.47253924
5DDR23.44873934
6STK38L3.05043135
7MAP4K22.84734196
8INSRR2.82844345
9PLK22.50139871
10BRD42.29616459
11MAPK152.26949846
12PRKD32.24598148
13WNK42.08977718
14PIK3CG2.00946907
15MAP3K21.96039195
16WNK11.90645962
17LATS11.86899000
18PTK2B1.79309888
19PNCK1.76364174
20NTRK31.68282208
21CAMKK21.66327540
22CAMK1G1.62078552
23MST1R1.46401537
24PDK11.39632703
25ADRBK21.38139168
26PDPK11.37391914
27DYRK1B1.37000935
28RIPK41.36097253
29STK391.03380748
30SGK4941.02320581
31SGK2231.02320581
32ACVR1B1.02141879
33MARK10.96647488
34SGK20.95642136
35GRK10.94021886
36UHMK10.91191388
37MAP3K40.88322292
38NEK60.87008792
39CAMK40.82210434
40PRKG10.80446110
41SIK20.79362148
42MAP2K20.77354856
43ZAK0.76143026
44CAMK10.72704257
45RPS6KA60.72214822
46PINK10.69695189
47NTRK20.64214430
48NLK0.62524269
49CDK70.60897365
50KSR20.59822863
51SGK10.59691974
52RPS6KA10.58471643
53OXSR10.58086661
54MAP3K70.57887348
55ADRBK10.57033126
56TXK0.54549934
57YES10.54421672
58BMPR1B0.53875919
59RPS6KL10.52855324
60RPS6KC10.52855324
61SGK30.52514436
62CDK120.51901829
63BRSK20.50652501
64CAMK1D0.50485250
65TAF10.50180971
66STK110.49363202
67OBSCN0.49280284
68WNK30.48483141
69PRKAA20.47427412
70BLK0.45478639
71MUSK0.45147147
72PRKG20.45102947
73CDK30.42732578
74CASK0.40921029
75GRK70.39460193
76CAMK2A0.39456745
77PKN10.37670978
78MST40.37131040
79GSK3B0.36592754
80MAPK80.36105857
81FER0.34272388
82ROCK10.33231033
83IKBKB0.31906853
84PRKCG0.31666150
85CDK190.31320343
86MAPK10.31301439
87PIM10.30967671
88MAP3K10.30538329
89GRK50.29702691
90BMPR20.29416008
91FGFR30.29261771
92PRKCB0.29127927
93PRKACA0.28616826
94DYRK30.27664091
95NUAK10.27553913
96MAPK130.27260651
97PRKCQ0.27196338
98RPS6KA40.25582117
99PRKCE0.25214419
100RPS6KA20.24555561

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000725.27824026
2Fatty acid biosynthesis_Homo sapiens_hsa000615.10639856
3Cyanoamino acid metabolism_Homo sapiens_hsa004603.88677327
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.80393663
5Olfactory transduction_Homo sapiens_hsa047402.97990165
6Taste transduction_Homo sapiens_hsa047422.44494351
7Butanoate metabolism_Homo sapiens_hsa006502.32049892
8Phototransduction_Homo sapiens_hsa047442.28356730
9Dorso-ventral axis formation_Homo sapiens_hsa043201.81813189
10Glycerophospholipid metabolism_Homo sapiens_hsa005641.72492373
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.68774187
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68505322
13Fatty acid degradation_Homo sapiens_hsa000711.63867795
14ABC transporters_Homo sapiens_hsa020101.59996893
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44217809
16Renin secretion_Homo sapiens_hsa049241.40433811
17Calcium signaling pathway_Homo sapiens_hsa040201.33380421
18Morphine addiction_Homo sapiens_hsa050321.27611864
19Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.23104786
20Glutamatergic synapse_Homo sapiens_hsa047241.19429972
21Salivary secretion_Homo sapiens_hsa049701.08521703
22Circadian entrainment_Homo sapiens_hsa047131.05268640
23Nicotine addiction_Homo sapiens_hsa050331.04263824
24Phenylalanine metabolism_Homo sapiens_hsa003601.03951965
25Nitrogen metabolism_Homo sapiens_hsa009101.02598218
26Glycerolipid metabolism_Homo sapiens_hsa005611.01566593
27Amphetamine addiction_Homo sapiens_hsa050310.98922941
28Serotonergic synapse_Homo sapiens_hsa047260.96706272
29Graft-versus-host disease_Homo sapiens_hsa053320.96229920
30Fatty acid metabolism_Homo sapiens_hsa012120.94916920
31Type II diabetes mellitus_Homo sapiens_hsa049300.92086790
32Primary bile acid biosynthesis_Homo sapiens_hsa001200.89900764
33Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.89512124
34Selenocompound metabolism_Homo sapiens_hsa004500.87057062
35Oocyte meiosis_Homo sapiens_hsa041140.83335266
36cAMP signaling pathway_Homo sapiens_hsa040240.83042694
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.82529957
38Linoleic acid metabolism_Homo sapiens_hsa005910.81979265
39VEGF signaling pathway_Homo sapiens_hsa043700.81974050
40GABAergic synapse_Homo sapiens_hsa047270.81174020
41Inositol phosphate metabolism_Homo sapiens_hsa005620.80090219
42Vascular smooth muscle contraction_Homo sapiens_hsa042700.79678602
43Tryptophan metabolism_Homo sapiens_hsa003800.79228102
44Oxytocin signaling pathway_Homo sapiens_hsa049210.78999752
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.78636796
46Autoimmune thyroid disease_Homo sapiens_hsa053200.77850646
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.77768256
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.77367771
49Chemical carcinogenesis_Homo sapiens_hsa052040.77250098
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.75840287
51Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.75693102
52Arachidonic acid metabolism_Homo sapiens_hsa005900.74346934
53Long-term potentiation_Homo sapiens_hsa047200.74222520
54B cell receptor signaling pathway_Homo sapiens_hsa046620.74048817
55Tyrosine metabolism_Homo sapiens_hsa003500.74035593
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73964358
57PPAR signaling pathway_Homo sapiens_hsa033200.72925935
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68402231
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67239197
60Retinol metabolism_Homo sapiens_hsa008300.67114989
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.66834456
62Renin-angiotensin system_Homo sapiens_hsa046140.66543165
63Hedgehog signaling pathway_Homo sapiens_hsa043400.63466667
64Histidine metabolism_Homo sapiens_hsa003400.63435388
65Allograft rejection_Homo sapiens_hsa053300.63035167
66Type I diabetes mellitus_Homo sapiens_hsa049400.62752814
67Cholinergic synapse_Homo sapiens_hsa047250.62096155
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61732039
69beta-Alanine metabolism_Homo sapiens_hsa004100.59841982
70Antigen processing and presentation_Homo sapiens_hsa046120.58574341
71T cell receptor signaling pathway_Homo sapiens_hsa046600.58376866
72Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.57236813
73Insulin secretion_Homo sapiens_hsa049110.56991973
74Arginine and proline metabolism_Homo sapiens_hsa003300.56775868
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54908380
76MAPK signaling pathway_Homo sapiens_hsa040100.54023171
77Aldosterone synthesis and secretion_Homo sapiens_hsa049250.52788313
78Protein digestion and absorption_Homo sapiens_hsa049740.52188409
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51806034
80Peroxisome_Homo sapiens_hsa041460.51381166
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49675945
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.49334295
83Cardiac muscle contraction_Homo sapiens_hsa042600.48826746
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48009302
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.48003945
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47809387
87Gastric acid secretion_Homo sapiens_hsa049710.44035416
88Bile secretion_Homo sapiens_hsa049760.42445450
89Glutathione metabolism_Homo sapiens_hsa004800.39225505
90Pancreatic secretion_Homo sapiens_hsa049720.38480431
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.37157330
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36653548
93Sulfur relay system_Homo sapiens_hsa041220.36045267
94Fat digestion and absorption_Homo sapiens_hsa049750.35359751
95Estrogen signaling pathway_Homo sapiens_hsa049150.34645036
96Fanconi anemia pathway_Homo sapiens_hsa034600.34612977
97Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30272055
98Caffeine metabolism_Homo sapiens_hsa002320.29636100
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.29439095
100Circadian rhythm_Homo sapiens_hsa047100.29202334

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