TMCO5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.83736875
2cell-cell recognition (GO:0009988)9.79083787
3epithelial cilium movement (GO:0003351)9.78446294
4response to pheromone (GO:0019236)9.37641121
5axonemal dynein complex assembly (GO:0070286)9.28736029
6cilium or flagellum-dependent cell motility (GO:0001539)9.27699345
7spermatid development (GO:0007286)8.87375186
8motile cilium assembly (GO:0044458)8.68291399
9cilium movement (GO:0003341)7.75108310
10single fertilization (GO:0007338)7.47723650
11synaptonemal complex assembly (GO:0007130)7.23408708
12male meiosis (GO:0007140)7.21583357
13epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.20102723
14synaptonemal complex organization (GO:0070193)7.14199450
15piRNA metabolic process (GO:0034587)7.11286537
16regulation of cilium movement (GO:0003352)7.01295891
17rRNA methylation (GO:0031167)6.59356136
18protein targeting to Golgi (GO:0000042)6.33969038
19phosphatidylethanolamine biosynthetic process (GO:0006646)6.30342223
20sperm capacitation (GO:0048240)6.30191718
21spermatid nucleus differentiation (GO:0007289)6.27174480
22microtubule depolymerization (GO:0007019)6.24645590
23fertilization (GO:0009566)6.17291910
24establishment of protein localization to Golgi (GO:0072600)6.12556506
25spermatogenesis (GO:0007283)5.96330412
26male gamete generation (GO:0048232)5.94455183
27retrograde transport, vesicle recycling within Golgi (GO:0000301)5.88295103
28phosphatidylethanolamine metabolic process (GO:0046337)5.87840560
29negative regulation of inclusion body assembly (GO:0090084)5.77965336
30cellular ketone body metabolic process (GO:0046950)5.68801842
31rRNA modification (GO:0000154)5.57268878
32gamete generation (GO:0007276)5.54641727
33single strand break repair (GO:0000012)5.24628063
34regulation of Rab GTPase activity (GO:0032313)5.13485450
35positive regulation of Rab GTPase activity (GO:0032851)5.13485450
36organic cation transport (GO:0015695)5.09247287
37calcium ion-dependent exocytosis (GO:0017156)5.03570434
38regulation of inclusion body assembly (GO:0090083)5.02599243
39ketone body metabolic process (GO:1902224)5.01552505
40cellular process involved in reproduction in multicellular organism (GO:0022412)4.98667351
41chromosome organization involved in meiosis (GO:0070192)4.97926659
42germ cell development (GO:0007281)4.94813985
43sexual reproduction (GO:0019953)4.91551036
44regulation of transcription involved in cell fate commitment (GO:0060850)4.80914835
45monoubiquitinated protein deubiquitination (GO:0035520)4.78221348
46male meiosis I (GO:0007141)4.77462066
47DNA methylation involved in gamete generation (GO:0043046)4.76416033
48cell recognition (GO:0008037)4.68086275
49RNA destabilization (GO:0050779)4.59766988
50protein localization to Golgi apparatus (GO:0034067)4.55976686
51meiotic nuclear division (GO:0007126)4.54959987
52glycerol ether metabolic process (GO:0006662)4.52567303
53ventricular system development (GO:0021591)4.47751418
54chromatin silencing (GO:0006342)4.40053341
55multicellular organismal reproductive process (GO:0048609)4.33266777
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.29688288
57microtubule severing (GO:0051013)4.28958697
58ether metabolic process (GO:0018904)4.17559070
59protein K11-linked deubiquitination (GO:0035871)4.10765818
60meiosis I (GO:0007127)4.10701811
61regulation of microtubule-based movement (GO:0060632)4.07663976
62chromosome condensation (GO:0030261)4.06121537
63coenzyme catabolic process (GO:0009109)4.03837325
64meiotic cell cycle (GO:0051321)3.76527929
65negative regulation of Rho protein signal transduction (GO:0035024)3.73427173
66DNA packaging (GO:0006323)3.72591912
67chaperone-mediated protein complex assembly (GO:0051131)3.68230079
68microtubule polymerization or depolymerization (GO:0031109)3.64878589
69musculoskeletal movement (GO:0050881)3.63904843
70multicellular organismal movement (GO:0050879)3.63904843
71seminiferous tubule development (GO:0072520)3.62557403
72regulation of somitogenesis (GO:0014807)3.50119877
73response to acidic pH (GO:0010447)3.46259918
74multicellular organismal development (GO:0007275)3.33491102
75protein-DNA complex disassembly (GO:0032986)3.32499565
76nucleosome disassembly (GO:0006337)3.32499565
77cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.32184223
78centriole assembly (GO:0098534)3.31148551
79regulation of phosphoprotein phosphatase activity (GO:0043666)3.29947130
80cellular response to pH (GO:0071467)3.29000312
81genitalia morphogenesis (GO:0035112)3.26118240
82cranial nerve morphogenesis (GO:0021602)3.24771495
83meiotic cell cycle process (GO:1903046)3.24135507
84histone exchange (GO:0043486)3.23626445
85cerebral cortex neuron differentiation (GO:0021895)3.22617412
86regulation of spindle checkpoint (GO:0090231)3.21603747
87alditol metabolic process (GO:0019400)3.20816842
88histone H3-K9 demethylation (GO:0033169)3.20767880
89centriole replication (GO:0007099)3.15959998
90sequestering of actin monomers (GO:0042989)3.14633916
91microtubule nucleation (GO:0007020)3.08436490
92regulation of interleukin-13 production (GO:0032656)3.07679674
93polyol catabolic process (GO:0046174)3.06672495
94nucleoside diphosphate phosphorylation (GO:0006165)3.04323717
95GTP biosynthetic process (GO:0006183)3.03348790
96nucleus organization (GO:0006997)3.02732831
97left/right pattern formation (GO:0060972)3.01199848
98mesenchymal cell differentiation involved in renal system development (GO:2001012)2.98472400
99mesenchymal cell differentiation involved in kidney development (GO:0072161)2.98472400
100negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.97381587
101negative regulation of gene expression, epigenetic (GO:0045814)2.92856177
102regulation of T-helper 2 cell differentiation (GO:0045628)2.91410436
103homeostasis of number of cells within a tissue (GO:0048873)2.91271749
104membrane protein intracellular domain proteolysis (GO:0031293)2.86051452
105protein polyglutamylation (GO:0018095)2.85409015
106cell differentiation involved in metanephros development (GO:0072202)2.78822099
107detection of chemical stimulus involved in sensory perception of smell (GO:0050911)2.78581791
108protein refolding (GO:0042026)2.77828959
109protein depolymerization (GO:0051261)2.77446456
110NAD biosynthetic process (GO:0009435)2.76977254
111glycerol metabolic process (GO:0006071)2.75734954
112mitotic sister chromatid cohesion (GO:0007064)2.72260343
113glycolytic process (GO:0006096)2.71510116
114positive regulation of skeletal muscle tissue development (GO:0048643)2.69389501
115UTP biosynthetic process (GO:0006228)2.68812224
116synapsis (GO:0007129)2.68078005
117regulation of centriole replication (GO:0046599)2.67398655
118regulation of meiosis I (GO:0060631)2.65881279
119cilium organization (GO:0044782)2.65878750
120sister chromatid cohesion (GO:0007062)2.60908618
121microtubule-based movement (GO:0007018)2.59752074
122polyamine biosynthetic process (GO:0006596)2.59407994
123cilium assembly (GO:0042384)2.58915273
124gene silencing by RNA (GO:0031047)2.55545697
125peptidyl-threonine dephosphorylation (GO:0035970)2.54329210
126cellular component assembly involved in morphogenesis (GO:0010927)2.53087297
127cilium morphogenesis (GO:0060271)2.50143898
128lactate metabolic process (GO:0006089)2.45959492
129single-organism membrane fusion (GO:0044801)2.44867392
130UTP metabolic process (GO:0046051)2.43474936
131protein localization to chromosome, centromeric region (GO:0071459)2.39347104
132axoneme assembly (GO:0035082)2.38254812
133carnitine transport (GO:0015879)2.38065213
134amino-acid betaine transport (GO:0015838)2.38065213
135cellular response to arsenic-containing substance (GO:0071243)2.37584215
136cell wall macromolecule catabolic process (GO:0016998)15.0241201
137cell wall macromolecule metabolic process (GO:0044036)15.0241201
138fusion of sperm to egg plasma membrane (GO:0007342)14.4938810
139sperm motility (GO:0030317)12.3325727
140multicellular organism reproduction (GO:0032504)11.5653488
141acrosome assembly (GO:0001675)11.1544189
142plasma membrane fusion (GO:0045026)11.0363809
143sperm-egg recognition (GO:0035036)10.9376250
144acrosome reaction (GO:0007340)10.2206572
145reproduction (GO:0000003)10.0876069

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.91883299
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.20878428
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.96118133
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.36524527
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20952440
6MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.19299975
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.10731465
8CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.93010653
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.88315463
10KAP1_22055183_ChIP-Seq_ESCs_Mouse2.55606279
11PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.54072160
12EZH2_22144423_ChIP-Seq_EOC_Human2.51936859
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.36740212
14CTBP1_25329375_ChIP-Seq_LNCAP_Human2.26187623
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.26086930
16CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.21220259
17VDR_22108803_ChIP-Seq_LS180_Human2.18248906
18KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.14316160
19VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.06988912
20FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00255783
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.99354036
22CBX2_27304074_Chip-Seq_ESCs_Mouse1.98068370
23GATA1_26923725_Chip-Seq_HPCs_Mouse1.97888113
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.95448678
25ZNF274_21170338_ChIP-Seq_K562_Hela1.90498251
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.88774601
27ERA_21632823_ChIP-Seq_H3396_Human1.88505645
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.88206868
29MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.85354846
30NANOG_20526341_ChIP-Seq_ESCs_Human1.82872137
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.82533538
32DROSHA_22980978_ChIP-Seq_HELA_Human1.81112018
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80444361
34UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.78183259
35EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.77344135
36* STAT1_17558387_ChIP-Seq_HELA_Human1.76833558
37RAC3_21632823_ChIP-Seq_H3396_Human1.75621219
38RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.74635478
39ER_23166858_ChIP-Seq_MCF-7_Human1.74016213
40GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.70586466
41MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68334561
42KDM2B_26808549_Chip-Seq_REH_Human1.66672585
43* TAL1_26923725_Chip-Seq_HPCs_Mouse1.62080330
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.61922953
45CTCF_27219007_Chip-Seq_Bcells_Human1.61405732
46SUZ12_27294783_Chip-Seq_NPCs_Mouse1.59781663
47AR_25329375_ChIP-Seq_VCAP_Human1.58528076
48MYC_19829295_ChIP-Seq_ESCs_Human1.56809693
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56511424
50TAF2_19829295_ChIP-Seq_ESCs_Human1.54925677
51TDRD3_21172665_ChIP-Seq_MCF-7_Human1.52829599
52* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.52563975
53AUTS2_25519132_ChIP-Seq_293T-REX_Human1.52369742
54PCGF2_27294783_Chip-Seq_NPCs_Mouse1.51832922
55GATA3_21867929_ChIP-Seq_TH1_Mouse1.51621778
56SMAD4_21741376_ChIP-Seq_EPCs_Human1.51191240
57ARNT_22903824_ChIP-Seq_MCF-7_Human1.50253296
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49607620
59GATA3_21867929_ChIP-Seq_CD8_Mouse1.49104896
60ELK4_26923725_Chip-Seq_MESODERM_Mouse1.48632697
61WDR5_24793694_ChIP-Seq_LNCAP_Human1.47540419
62OCT4_20526341_ChIP-Seq_ESCs_Human1.47451278
63BCL6_27268052_Chip-Seq_Bcells_Human1.47159662
64SOX2_22085726_ChIP-Seq_NPCs_Mouse1.46771885
65P300_19829295_ChIP-Seq_ESCs_Human1.45869489
66E2F1_20622854_ChIP-Seq_HELA_Human1.45641621
67FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.42610903
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41803162
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41572207
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.41363771
71SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40306226
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.40071770
73ETV2_25802403_ChIP-Seq_MESCs_Mouse1.39774802
74YY1_22570637_ChIP-Seq_MALME-3M_Human1.39644772
75PHF8_20622854_ChIP-Seq_HELA_Human1.38780737
76CTCF_20526341_ChIP-Seq_ESCs_Human1.38616045
77AR_21572438_ChIP-Seq_LNCaP_Human1.37298004
78TP53_18474530_ChIP-ChIP_U2OS_Human1.36864033
79FLI1_21867929_ChIP-Seq_TH2_Mouse1.36751371
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.35385453
81SMC4_20622854_ChIP-Seq_HELA_Human1.35046837
82SMAD3_21741376_ChIP-Seq_ESCs_Human1.33374336
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33261855
84TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32902624
85* NANOG_18555785_Chip-Seq_ESCs_Mouse1.32102790
86* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31775154
87BCOR_27268052_Chip-Seq_Bcells_Human1.30545578
88P300_27268052_Chip-Seq_Bcells_Human1.28159018
89P68_20966046_ChIP-Seq_HELA_Human1.27849517
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.27185846
91GATA3_21878914_ChIP-Seq_MCF-7_Human1.27014177
92CBX2_22325352_ChIP-Seq_293T-Rex_Human1.26812789
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.25729973
94RBPJ_21746931_ChIP-Seq_IB4_Human1.25453273
95TP63_22573176_ChIP-Seq_HFKS_Human1.24993763
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.24780695
97PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.23831329
98CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.23719470
99ETV1_20927104_ChIP-Seq_GIST48_Human1.23461360
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.23451547
101TAF15_26573619_Chip-Seq_HEK293_Human1.22665467
102SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.22295986
103* CMYC_18555785_Chip-Seq_ESCs_Mouse1.22139228
104IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.21941657
105CBP_20019798_ChIP-Seq_JUKART_Human1.21941657
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.21713823
107RUNX2_22187159_ChIP-Seq_PCA_Human1.20893924
108* OCT4_18555785_Chip-Seq_ESCs_Mouse1.20668223
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20489499
110P53_21459846_ChIP-Seq_SAOS-2_Human1.20098082
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18644642
112ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.18188574
113EZH2_27294783_Chip-Seq_NPCs_Mouse1.17878066
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17533420
115SOX2_19829295_ChIP-Seq_ESCs_Human1.16480417
116NANOG_19829295_ChIP-Seq_ESCs_Human1.16480417
117* P53_22387025_ChIP-Seq_ESCs_Mouse1.15809715
118P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.15764159
119SMAD4_21799915_ChIP-Seq_A2780_Human1.15763549
120CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.15069653
121TBL1_22424771_ChIP-Seq_293T_Human1.14781220
122CEBPB_22108803_ChIP-Seq_LS180_Human1.14763149
123* KLF4_18555785_Chip-Seq_ESCs_Mouse1.12565648
124* P300_18555785_Chip-Seq_ESCs_Mouse1.12520382
125GF1_26923725_Chip-Seq_HPCs_Mouse1.12331501
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12288501
127RUNX1_26923725_Chip-Seq_HPCs_Mouse1.12190005
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.11894059
129REST_21632747_ChIP-Seq_MESCs_Mouse1.11836899
130SMAD4_21741376_ChIP-Seq_HESCs_Human1.11579312
131TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.11135451
132* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09471223
133OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08840287
134SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.07968946
135SMRT_27268052_Chip-Seq_Bcells_Human1.06816558
136FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06682317
137SOX9_26525672_Chip-Seq_HEART_Mouse1.05618938
138ESET_19884257_ChIP-Seq_ESCs_Mouse1.05365950
139PHF8_20622853_ChIP-Seq_HELA_Human1.04833457
140SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04753413
141* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04170705
142STAT3_23295773_ChIP-Seq_U87_Human1.03595890
143RNF2_27304074_Chip-Seq_NSC_Mouse1.03308210
144* SOX2_18555785_Chip-Seq_ESCs_Mouse1.03191579
145OCT1_27270436_Chip-Seq_PROSTATE_Human1.03073395
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03012371
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02531648
148FLI1_21867929_ChIP-Seq_CD8_Mouse1.02058309
149* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01990234
150FUS_26573619_Chip-Seq_HEK293_Human1.01504285
151EZH2_27304074_Chip-Seq_ESCs_Mouse1.01191813
152* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.01131806
153KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.00419953
154PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99920155
155SPI1_26923725_Chip-Seq_HPCs_Mouse0.99647538
156GF1B_26923725_Chip-Seq_HPCs_Mouse0.98278307
157PU1_27457419_Chip-Seq_LIVER_Mouse0.96812812
158TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96646980
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96646980
160* CTCF_18555785_Chip-Seq_ESCs_Mouse0.94339126
161ERG_20517297_ChIP-Seq_VCAP_Human0.94294055
162NFYB_21822215_ChIP-Seq_K562_Human0.93300316
163LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93020568
164* NMYC_18555785_Chip-Seq_ESCs_Mouse0.90868876
165PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.90799272
166EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.90478306
167* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89285617
168RAD21_21589869_ChIP-Seq_MESCs_Mouse0.89119385
169* SMAD1_18555785_Chip-Seq_ESCs_Mouse0.89057808
170* E2F1_18555785_Chip-Seq_ESCs_Mouse0.88708684
171FOXM1_23109430_ChIP-Seq_U2OS_Human0.86773045

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.98819586
2MP0001929_abnormal_gametogenesis5.74723869
3MP0008877_abnormal_DNA_methylation4.72779010
4MP0002210_abnormal_sex_determination3.76488019
5MP0002161_abnormal_fertility/fecundity3.43148569
6MP0001348_abnormal_lacrimal_gland3.18697212
7MP0001145_abnormal_male_reproductive3.17163084
8MP0000653_abnormal_sex_gland2.90520116
9MP0002653_abnormal_ependyma_morphology2.55932393
10MP0005670_abnormal_white_adipose2.47806353
11MP0000678_abnormal_parathyroid_gland2.37249340
12MP0005423_abnormal_somatic_nervous2.10512935
13MP0005410_abnormal_fertilization15.0449251
14MP0002132_abnormal_respiratory_system1.84372823
15MP0002102_abnormal_ear_morphology1.73279745
16MP0008058_abnormal_DNA_repair1.67737259
17MP0005379_endocrine/exocrine_gland_phen1.66410862
18MP0001485_abnormal_pinna_reflex1.63443233
19MP0001486_abnormal_startle_reflex1.61883598
20MP0002160_abnormal_reproductive_system1.58617815
21MP0003718_maternal_effect1.58027295
22MP0010094_abnormal_chromosome_stability1.57356459
23MP0009053_abnormal_anal_canal1.55686845
24MP0002249_abnormal_larynx_morphology1.53803506
25MP0002822_catalepsy1.50858907
26MP0004233_abnormal_muscle_weight1.48961378
27MP0003646_muscle_fatigue1.42030030
28MP0003111_abnormal_nucleus_morphology1.40830093
29MP0004742_abnormal_vestibular_system1.35835238
30MP0001968_abnormal_touch/_nociception1.33344927
31MP0004859_abnormal_synaptic_plasticity1.33044238
32MP0000534_abnormal_ureter_morphology1.30471936
33MP0003880_abnormal_central_pattern1.27029491
34MP0002127_abnormal_cardiovascular_syste1.26741771
35MP0002735_abnormal_chemical_nociception1.24557633
36MP0003693_abnormal_embryo_hatching1.24291419
37MP0005310_abnormal_salivary_gland1.20662459
38MP0001963_abnormal_hearing_physiology1.16401577
39MP0001765_abnormal_ion_homeostasis1.14209327
40MP0000026_abnormal_inner_ear1.11067344
41MP0009046_muscle_twitch1.10263006
42MP0000049_abnormal_middle_ear1.09533123
43MP0005623_abnormal_meninges_morphology1.08227158
44MP0005647_abnormal_sex_gland1.02864512
45MP0000955_abnormal_spinal_cord1.00248569
46MP0002282_abnormal_trachea_morphology0.99561182
47MP0005389_reproductive_system_phenotype0.96785577
48MP0005248_abnormal_Harderian_gland0.93782076
49MP0003699_abnormal_female_reproductive0.93381493
50MP0005451_abnormal_body_composition0.92214741
51MP0003077_abnormal_cell_cycle0.91600033
52MP0003329_amyloid_beta_deposits0.91268565
53MP0004510_myositis0.91189632
54MP0002138_abnormal_hepatobiliary_system0.90424113
55MP0002557_abnormal_social/conspecific_i0.90073638
56MP0008057_abnormal_DNA_replication0.89707850
57MP0002234_abnormal_pharynx_morphology0.87344283
58MP0002067_abnormal_sensory_capabilities0.84982560
59MP0003786_premature_aging0.83775753
60MP0001119_abnormal_female_reproductive0.81565288
61MP0004085_abnormal_heartbeat0.80139864
62MP0009745_abnormal_behavioral_response0.79522120
63MP0002572_abnormal_emotion/affect_behav0.78820488
64MP0008007_abnormal_cellular_replicative0.78037640
65MP0002272_abnormal_nervous_system0.77795647
66MP0001984_abnormal_olfaction0.76356945
67MP0002733_abnormal_thermal_nociception0.75668187
68MP0001879_abnormal_lymphatic_vessel0.75059606
69MP0004957_abnormal_blastocyst_morpholog0.74576826
70MP0008569_lethality_at_weaning0.74151386
71MP0005636_abnormal_mineral_homeostasis0.73945037
72MP0005377_hearing/vestibular/ear_phenot0.70287192
73MP0003878_abnormal_ear_physiology0.70287192
74MP0005367_renal/urinary_system_phenotyp0.70165279
75MP0000516_abnormal_urinary_system0.70165279
76MP0008995_early_reproductive_senescence0.66599474
77MP0006292_abnormal_olfactory_placode0.64830138
78MP0001970_abnormal_pain_threshold0.64516530
79MP0000681_abnormal_thyroid_gland0.63562457
80MP0000358_abnormal_cell_content/0.63430427
81MP0003119_abnormal_digestive_system0.63391681
82MP0005395_other_phenotype0.62656655
83MP0004484_altered_response_of0.62062082
84MP0003635_abnormal_synaptic_transmissio0.60872093
85MP0001501_abnormal_sleep_pattern0.60071822
86MP0002734_abnormal_mechanical_nocicepti0.59633707
87MP0001730_embryonic_growth_arrest0.59591916
88MP0003137_abnormal_impulse_conducting0.58618118
89MP0006276_abnormal_autonomic_nervous0.57324820
90MP0008932_abnormal_embryonic_tissue0.56031738
91MP0004019_abnormal_vitamin_homeostasis0.54976415
92MP0003283_abnormal_digestive_organ0.54712548
93MP0001666_abnormal_nutrient_absorption0.53635077
94MP0002269_muscular_atrophy0.53436074
95MP0001529_abnormal_vocalization0.51093193
96MP0005167_abnormal_blood-brain_barrier0.50733399
97MP0004036_abnormal_muscle_relaxation0.49923523
98MP0006036_abnormal_mitochondrial_physio0.49629470
99MP0005083_abnormal_biliary_tract0.49028569
100MP0001764_abnormal_homeostasis0.48321245
101MP0000470_abnormal_stomach_morphology0.48156512
102MP0003011_delayed_dark_adaptation0.47643795
103MP0002928_abnormal_bile_duct0.47487516
104MP0010386_abnormal_urinary_bladder0.47247996
105MP0010307_abnormal_tumor_latency0.46537168
106MP0001661_extended_life_span0.45917828
107MP0005535_abnormal_body_temperature0.45554906
108MP0000566_synostosis0.44600095
109MP0002882_abnormal_neuron_morphology0.44173862
110MP0008961_abnormal_basal_metabolism0.43828378
111MP0004145_abnormal_muscle_electrophysio0.43188403
112MP0000604_amyloidosis0.41655223
113MP0005375_adipose_tissue_phenotype0.41629379
114MP0005551_abnormal_eye_electrophysiolog0.40863100
115MP0002752_abnormal_somatic_nervous0.38879284
116MP0000230_abnormal_systemic_arterial0.38776420
117MP0005084_abnormal_gallbladder_morpholo0.38586197
118MP0001293_anophthalmia0.37422734
119MP0006035_abnormal_mitochondrial_morpho0.37370071
120MP0000613_abnormal_salivary_gland0.36835131
121MP0003950_abnormal_plasma_membrane0.36786499
122MP0004084_abnormal_cardiac_muscle0.35809877
123MP0001672_abnormal_embryogenesis/_devel0.35494606
124MP0005380_embryogenesis_phenotype0.35494606
125MP0002736_abnormal_nociception_after0.34000715
126MP0001697_abnormal_embryo_size0.33911361
127MP0003315_abnormal_perineum_morphology0.33615629
128MP0000313_abnormal_cell_death0.33267457
129MP0005253_abnormal_eye_physiology0.32402882
130MP0003879_abnormal_hair_cell0.32144485
131MP0001324_abnormal_eye_pigmentation0.31817316
132MP0006072_abnormal_retinal_apoptosis0.31471712
133MP0005666_abnormal_adipose_tissue0.28932037
134MP0002085_abnormal_embryonic_tissue0.28811719
135MP0009115_abnormal_fat_cell0.28373105
136MP0002080_prenatal_lethality0.28284722
137MP0004270_analgesia0.28264976
138MP0003115_abnormal_respiratory_system0.28167807
139MP0005391_vision/eye_phenotype0.27878025
140MP0002084_abnormal_developmental_patter0.27750975
141MP0001545_abnormal_hematopoietic_system0.26769147
142MP0005397_hematopoietic_system_phenotyp0.26769147
143MP0001919_abnormal_reproductive_system0.26162525
144MP0002971_abnormal_brown_adipose0.24860961
145MP0003984_embryonic_growth_retardation0.24082239
146MP0003861_abnormal_nervous_system0.23999327
147MP0002169_no_abnormal_phenotype0.23763920
148MP0002873_normal_phenotype0.23548445
149MP0003221_abnormal_cardiomyocyte_apopto0.23463683
150MP0009697_abnormal_copulation0.23381686
151MP0001727_abnormal_embryo_implantation0.23273888
152MP0001849_ear_inflammation0.22528655
153MP0003937_abnormal_limbs/digits/tail_de0.22372692
154MP0003631_nervous_system_phenotype0.22339256
155MP0001905_abnormal_dopamine_level0.21945417
156MP0002088_abnormal_embryonic_growth/wei0.21028541
157MP0003936_abnormal_reproductive_system0.20879069
158MP0000350_abnormal_cell_proliferation0.20081148
159MP0001440_abnormal_grooming_behavior0.20073802
160MP0000001_mammalian_phenotype0.20047942
161MP0002229_neurodegeneration0.19839743
162MP0005319_abnormal_enzyme/_coenzyme0.19774523

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium morphology (HP:0005938)9.42772433
2Abnormal respiratory epithelium morphology (HP:0012253)9.42772433
3Abnormal respiratory motile cilium physiology (HP:0012261)9.27371878
4Severe visual impairment (HP:0001141)7.61294775
5Abnormal ciliary motility (HP:0012262)7.59787465
6Chronic bronchitis (HP:0004469)7.59007864
7Rhinitis (HP:0012384)7.44545512
8Infertility (HP:0000789)6.44107256
9Nasal polyposis (HP:0100582)5.72922914
10Male infertility (HP:0003251)5.46092319
11Attenuation of retinal blood vessels (HP:0007843)5.14632050
12Bony spicule pigmentary retinopathy (HP:0007737)5.05363181
13Abnormality of the nasal mucosa (HP:0000433)4.63739019
14Resting tremor (HP:0002322)4.39994615
15Chronic hepatic failure (HP:0100626)4.33029798
16Bronchitis (HP:0012387)4.23135176
17Bronchiectasis (HP:0002110)4.22843921
18Hyperkalemia (HP:0002153)4.19041213
19Bell-shaped thorax (HP:0001591)4.15104605
20Abnormal rod and cone electroretinograms (HP:0008323)4.14468306
21Abnormality of macular pigmentation (HP:0008002)4.06567842
22Hypoplastic ischia (HP:0003175)3.98796068
23Abnormal spermatogenesis (HP:0008669)3.89993327
24Facial shape deformation (HP:0011334)3.86871661
25Potter facies (HP:0002009)3.86871661
26Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.80249776
27Recurrent sinusitis (HP:0011108)3.66765935
28Nephronophthisis (HP:0000090)3.65874262
29Abnormality of the ischium (HP:0003174)3.60582886
30Enlarged epiphyses (HP:0010580)3.48550461
31Aplasia/Hypoplasia of the earlobes (HP:0009906)3.40628903
32Unilateral renal agenesis (HP:0000122)3.35610695
33Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.24530600
34Cone-rod dystrophy (HP:0000548)3.21723703
35Postural instability (HP:0002172)3.14766948
36Medial flaring of the eyebrow (HP:0010747)3.10085972
37Recurrent otitis media (HP:0000403)3.06616512
38Azoospermia (HP:0000027)2.89905639
39Double outlet right ventricle (HP:0001719)2.89244268
40Congenital malformation of the right heart (HP:0011723)2.89244268
41Abnormal urine output (HP:0012590)2.88120443
42Renal dysplasia (HP:0000110)2.87185881
43Hypoplasia of the thymus (HP:0000778)2.85915311
44Abnormality of the aortic arch (HP:0012303)2.79818594
45Abnormality of the renal medulla (HP:0100957)2.76929005
46Progressive cerebellar ataxia (HP:0002073)2.72901295
47Generalized aminoaciduria (HP:0002909)2.69146265
48Abnormality of potassium homeostasis (HP:0011042)2.64207526
49Hypoalphalipoproteinemia (HP:0003233)2.59543481
50Tubulointerstitial nephritis (HP:0001970)2.58610392
51Amelogenesis imperfecta (HP:0000705)2.56822208
52Abnormality of midbrain morphology (HP:0002418)2.50270785
53Molar tooth sign on MRI (HP:0002419)2.50270785
54Truncal obesity (HP:0001956)2.41681524
55Progressive sensorineural hearing impairment (HP:0000408)2.40973130
56Impulsivity (HP:0100710)2.39283591
57Polyuria (HP:0000103)2.38516502
58Abnormality of dental color (HP:0011073)2.35630347
59Abnormality of the costochondral junction (HP:0000919)2.29219388
60Myokymia (HP:0002411)2.28170551
61Abnormality of the parathyroid morphology (HP:0011766)2.25386556
62Portal hypertension (HP:0001409)2.25134711
63Gait imbalance (HP:0002141)2.24399253
64Congenital primary aphakia (HP:0007707)2.22913475
65Epiphyseal dysplasia (HP:0002656)2.14648241
66Insulin-resistant diabetes mellitus (HP:0000831)2.09697954
67Abnormality of the pubic bones (HP:0003172)2.08459187
68Occipital encephalocele (HP:0002085)2.07370933
69Tetany (HP:0001281)2.06954526
70Tubular atrophy (HP:0000092)2.04703144
71Abnormality of the hepatic vasculature (HP:0006707)2.04481737
72Ventricular tachycardia (HP:0004756)2.03224953
73Bundle branch block (HP:0011710)2.02728377
74Widely patent fontanelles and sutures (HP:0004492)2.02629126
75Dynein arm defect of respiratory motile cilia (HP:0012255)13.4057822
76Absent/shortened dynein arms (HP:0200106)13.4057822
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0081787
78Menstrual irregularities (HP:0000858)1.99916774
79Recurrent bronchitis (HP:0002837)1.99220051
80Renovascular hypertension (HP:0100817)1.97437971
81Hypophosphatemic rickets (HP:0004912)1.95412925
82Abnormality of the epiphysis of the femoral head (HP:0010574)1.94187156
83Osteomalacia (HP:0002749)1.93986669
84Mixed hearing impairment (HP:0000410)1.93390751
85Aplasia/Hypoplasia of the sacrum (HP:0008517)1.92241881
86Tubulointerstitial abnormality (HP:0001969)1.91190116
87Renal Fanconi syndrome (HP:0001994)1.89452765
88Nephrogenic diabetes insipidus (HP:0009806)1.89423757
89Hyponatremia (HP:0002902)1.89177190
90Cerebellar dysplasia (HP:0007033)1.88923862
91Gonadotropin excess (HP:0000837)1.88463034
92Pancreatic fibrosis (HP:0100732)1.86917834
93Abnormal ventriculo-arterial connection (HP:0011563)1.85962455
94Transposition of the great arteries (HP:0001669)1.85962455
95Abnormal connection of the cardiac segments (HP:0011545)1.85962455
96Recurrent corneal erosions (HP:0000495)1.84825507
97Congenital sensorineural hearing impairment (HP:0008527)1.84321474
98Hypokalemia (HP:0002900)1.84081654
99Flattened epiphyses (HP:0003071)1.84064612
100Flat capital femoral epiphysis (HP:0003370)1.80280487
101Type II lissencephaly (HP:0007260)1.80217968
102Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78672608
103Abnormality of femoral epiphyses (HP:0006499)1.78672608
104Tongue fasciculations (HP:0001308)1.77888579
105Poor coordination (HP:0002370)1.76900700
106Abnormality of permanent molar morphology (HP:0011071)1.75559917
107Abnormality of the dental root (HP:0006486)1.75559917
108Taurodontia (HP:0000679)1.75559917
109Supernumerary spleens (HP:0009799)1.74507959
110Increased purine levels (HP:0004368)1.73934555
111Asymmetric septal hypertrophy (HP:0001670)1.72143226
112Chronic sinusitis (HP:0011109)1.71686596
113Vaginal atresia (HP:0000148)1.66442239
114Aplasia/Hypoplasia of the lens (HP:0008063)1.65401243
115Genital tract atresia (HP:0001827)1.63331071
116Muscle fibrillation (HP:0010546)1.62066252
117Abnormality of molar (HP:0011077)1.62045084
118Abnormality of molar morphology (HP:0011070)1.62045084
119Abnormality of the dental pulp (HP:0006479)1.60790971
120Hypoplasia of the capital femoral epiphysis (HP:0003090)1.60483584
121Spastic tetraparesis (HP:0001285)1.57947696
122Postaxial foot polydactyly (HP:0001830)1.55842427
123Pancreatic cysts (HP:0001737)1.54586017
124Papillary thyroid carcinoma (HP:0002895)1.54427285
125Type 2 muscle fiber atrophy (HP:0003554)1.52934769
126Stage 5 chronic kidney disease (HP:0003774)1.52750917
127Abnormal gallbladder physiology (HP:0012438)1.51911675
128Cholecystitis (HP:0001082)1.51911675
129Abnormality of renal excretion (HP:0011036)1.47581448
130Abnormality of the renal cortex (HP:0011035)1.45456515
131Oculomotor apraxia (HP:0000657)1.44139367
132Postaxial hand polydactyly (HP:0001162)1.43520365
133Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.42191339
134Abnormality of saccadic eye movements (HP:0000570)1.41730204
135Dyschromatopsia (HP:0007641)1.40790782
136Decreased central vision (HP:0007663)1.39072583
137Congenital hepatic fibrosis (HP:0002612)1.36116567
138Aplasia/Hypoplasia of the tongue (HP:0010295)1.35715710
139Microglossia (HP:0000171)1.35707405
140Heterotopia (HP:0002282)1.34916071
141Optic nerve hypoplasia (HP:0000609)1.33191712
142Sensory axonal neuropathy (HP:0003390)1.30518425
143Muscle fiber atrophy (HP:0100295)1.30075405
144Tubulointerstitial fibrosis (HP:0005576)1.28210310
145Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.27069770
146Abnormality of renal resorption (HP:0011038)1.25878868
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.25869337
148Absent epiphyses (HP:0010577)1.25869337
149Breast carcinoma (HP:0003002)1.25845532
150True hermaphroditism (HP:0010459)1.25599966
151Glucose intolerance (HP:0000833)1.23359228
152Abnormality of ocular smooth pursuit (HP:0000617)1.23092230
153Short nail (HP:0001799)1.22446455
154Abnormality of the neuromuscular junction (HP:0003398)1.22189663
155Fatigable weakness (HP:0003473)1.22189663
156Cystic liver disease (HP:0006706)1.21114565
157Vascular calcification (HP:0004934)1.20790234
158Short ribs (HP:0000773)1.20695279
159Facial cleft (HP:0002006)1.19865396
160Polydipsia (HP:0001959)1.19236137
161Abnormal drinking behavior (HP:0030082)1.19236137
162Oligodactyly (hands) (HP:0001180)1.18719527
163Impaired smooth pursuit (HP:0007772)1.18361533
164Constricted visual fields (HP:0001133)1.17364169
165Bile duct proliferation (HP:0001408)1.15901707
166Abnormal biliary tract physiology (HP:0012439)1.15901707
167Easy fatigability (HP:0003388)1.14684920
168Personality changes (HP:0000751)1.13269930
169Broad foot (HP:0001769)1.12117507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.56570531
2PDK39.56570531
3PDK26.26466706
4DDR24.78376954
5INSRR3.54408469
6TESK13.33089187
7MAP4K23.31229037
8PLK23.04474105
9PRKD32.77150768
10BRD42.64381807
11ICK2.36224914
12PLK41.92787682
13PNCK1.90360767
14PIK3CG1.67822560
15NEK21.54075801
16MST1R1.48732526
17STK391.48557827
18BUB11.37399126
19WEE11.31671752
20PTK2B1.30781437
21WNK41.28012191
22CDK71.19660768
23STK381.10908397
24TESK21.03543285
25TTK1.01916856
26PDK11.01061600
27DYRK30.99822197
28IRAK10.99314106
29MAP3K90.98308013
30SIK20.94064736
31CHEK20.91193260
32PINK10.89097442
33MAP3K40.87434812
34UHMK10.83587900
35DYRK1B0.82560266
36STK38L0.81262627
37LMTK20.78610653
38KSR20.73677475
39FRK0.70973845
40PLK10.70203491
41TYRO30.69837670
42STK30.69467321
43CDC70.66694848
44RPS6KA20.66133342
45CAMK1D0.65861777
46CAMK10.65762355
47TLK10.64477441
48BRSK20.64141428
49MAP2K20.63629990
50ZAK0.63600271
51PRKG20.62904089
52PRKAA20.61984363
53CCNB10.61572802
54RPS6KA10.59754675
55ROCK10.59095430
56MUSK0.57064490
57EIF2AK10.56730486
58ADRBK20.56529055
59BMPR1B0.56314487
60CHEK10.51556556
61SGK4940.50486489
62SGK2230.50486489
63IRAK20.50290741
64TNIK0.49587634
65MAP3K110.48803324
66MAP3K20.46756308
67MAP2K60.43565187
68PDPK10.43025263
69BRAF0.42458835
70CAMK40.41806183
71BRSK10.40916796
72PAK10.40822371
73RPS6KA60.37749238
74MAP2K70.37684035
75MAPK10.37630877
76SRPK10.36386095
77NEK60.36319073
78TIE10.35838663
79RIPK40.35431345
80MAPK80.34123933
81RPS6KC10.33967309
82RPS6KL10.33967309
83NTRK30.33254534
84CDK40.32230954
85DYRK20.31066826
86ATM0.29910980
87LATS20.29749775
88NTRK20.29256935
89OBSCN0.28585044
90LATS10.27665059
91PRKCG0.27292518
92SGK10.26769223
93WNK10.26758491
94AURKA0.26743592
95PRKAA10.25306051
96EEF2K0.24434616
97EPHA20.24317206
98PRKCB0.24220925
99MAPKAPK50.23490313
100AURKB0.22863328
101MAPK130.21819084
102PLK30.21668986
103MAPK140.21622106
104ATR0.21578377
105PASK0.19813340
106VRK10.19580615
107MAP3K10.19098846
108PKN10.18801309
109BMPR20.18683843
110FER0.18581327
111PRKCE0.18494046
112MAP3K60.18423159
113MAP3K70.17785377
114ACVR1B0.17461220
115MAPK150.16950105
116PRKACA0.16890240
117AKT30.16390085
118CSNK2A10.16267124
119MELK0.15858282
120MINK10.15517441
121MOS0.14706326
122EIF2AK30.14285020
123MET0.13264780
124NUAK10.13217732
125SGK20.13041797
126MAP3K50.12463752
127CDK20.11521074
128MTOR0.11057964
129CDK10.11056637
130MARK30.11039870
131CSNK2A20.09761814
132PRKG10.09755554
133MAP3K80.09410777
134PBK0.08389449
135CDK150.08369635
136STK100.08321485
137MARK10.07833110
138CSNK1E0.07694342
139PRKACB0.07516856
140CDK30.07151094
141ERBB40.06942134
142OXSR10.06589158
143CSNK1D0.06122009
144PRKCZ0.05978356
145CDK140.05952537
146PAK60.05585655
147CDK120.05416691
148CDK180.05386615
149GSK3B0.05115825
150CAMK2A0.04493067
151CDK11A0.03811088
152CAMK1G0.03084312
153MARK20.01903589
154WNK30.01728863
155MAPK100.01643581
156PRKACG0.01131741

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000727.68996162
2Vitamin B6 metabolism_Homo sapiens_hsa007506.41832547
3Olfactory transduction_Homo sapiens_hsa047403.91230969
4Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.75624195
5Basal transcription factors_Homo sapiens_hsa030223.44331645
6Pyruvate metabolism_Homo sapiens_hsa006203.16600577
7Butanoate metabolism_Homo sapiens_hsa006502.86074802
8Fatty acid biosynthesis_Homo sapiens_hsa000612.71932340
9Oocyte meiosis_Homo sapiens_hsa041142.61845678
10Propanoate metabolism_Homo sapiens_hsa006402.54729739
11Linoleic acid metabolism_Homo sapiens_hsa005912.49764181
12alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.47133359
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.35231699
14Pentose phosphate pathway_Homo sapiens_hsa000302.31406614
15Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.20031135
16Glucagon signaling pathway_Homo sapiens_hsa049222.02170425
17RNA transport_Homo sapiens_hsa030132.01590863
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.90991400
19Taste transduction_Homo sapiens_hsa047421.90879756
20Selenocompound metabolism_Homo sapiens_hsa004501.90297378
21Fanconi anemia pathway_Homo sapiens_hsa034601.87950471
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85625851
23Glycerolipid metabolism_Homo sapiens_hsa005611.81328427
24Phenylalanine metabolism_Homo sapiens_hsa003601.79110452
25Glycerophospholipid metabolism_Homo sapiens_hsa005641.78566272
26Proteasome_Homo sapiens_hsa030501.73611852
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.67703374
28Purine metabolism_Homo sapiens_hsa002301.66845052
29Phototransduction_Homo sapiens_hsa047441.64142327
30Type I diabetes mellitus_Homo sapiens_hsa049401.61341367
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.55391739
32Allograft rejection_Homo sapiens_hsa053301.53451694
33Mineral absorption_Homo sapiens_hsa049781.51853278
34Type II diabetes mellitus_Homo sapiens_hsa049301.51143550
35Autoimmune thyroid disease_Homo sapiens_hsa053201.50438168
36Ether lipid metabolism_Homo sapiens_hsa005651.46676705
37Fructose and mannose metabolism_Homo sapiens_hsa000511.42597209
38Graft-versus-host disease_Homo sapiens_hsa053321.41746683
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36351469
40Nicotine addiction_Homo sapiens_hsa050331.34168455
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.33836695
42Carbon metabolism_Homo sapiens_hsa012001.32489016
43Cell cycle_Homo sapiens_hsa041101.29576316
44Morphine addiction_Homo sapiens_hsa050321.24282320
45Huntingtons disease_Homo sapiens_hsa050161.20059534
46Arginine and proline metabolism_Homo sapiens_hsa003301.19653163
47Pyrimidine metabolism_Homo sapiens_hsa002401.19150998
48Dorso-ventral axis formation_Homo sapiens_hsa043201.15460352
49PPAR signaling pathway_Homo sapiens_hsa033201.14981380
50Biosynthesis of amino acids_Homo sapiens_hsa012301.14621402
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.13950040
52Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10086576
53Circadian entrainment_Homo sapiens_hsa047131.09830034
54mRNA surveillance pathway_Homo sapiens_hsa030151.08104185
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07967330
56Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06326359
57Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05851472
58Glutathione metabolism_Homo sapiens_hsa004801.03318079
59Collecting duct acid secretion_Homo sapiens_hsa049661.02703466
60Cardiac muscle contraction_Homo sapiens_hsa042600.97822924
61Homologous recombination_Homo sapiens_hsa034400.96963266
62Amphetamine addiction_Homo sapiens_hsa050310.94597120
63cAMP signaling pathway_Homo sapiens_hsa040240.89521116
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.88175606
65Viral myocarditis_Homo sapiens_hsa054160.86373405
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.85923094
67Glutamatergic synapse_Homo sapiens_hsa047240.83646280
68Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.83381493
69RNA degradation_Homo sapiens_hsa030180.82323733
70Tyrosine metabolism_Homo sapiens_hsa003500.81272823
71Arginine biosynthesis_Homo sapiens_hsa002200.80948373
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80052323
73Antigen processing and presentation_Homo sapiens_hsa046120.79460259
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.78858546
75Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78742661
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.77731138
77Nitrogen metabolism_Homo sapiens_hsa009100.75341115
78Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.75025087
79ABC transporters_Homo sapiens_hsa020100.74906935
80Inositol phosphate metabolism_Homo sapiens_hsa005620.71680415
81Fatty acid metabolism_Homo sapiens_hsa012120.71050385
82Retinol metabolism_Homo sapiens_hsa008300.70086386
83RNA polymerase_Homo sapiens_hsa030200.69349533
84Arachidonic acid metabolism_Homo sapiens_hsa005900.67262189
85GABAergic synapse_Homo sapiens_hsa047270.66557610
86Fat digestion and absorption_Homo sapiens_hsa049750.65622303
87Metabolic pathways_Homo sapiens_hsa011000.64779223
88p53 signaling pathway_Homo sapiens_hsa041150.64203946
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63969190
90Vascular smooth muscle contraction_Homo sapiens_hsa042700.63148120
91Chemical carcinogenesis_Homo sapiens_hsa052040.59538524
92DNA replication_Homo sapiens_hsa030300.58462915
93Serotonergic synapse_Homo sapiens_hsa047260.57117463
94Cholinergic synapse_Homo sapiens_hsa047250.55206961
95Spliceosome_Homo sapiens_hsa030400.54378803
96Renin secretion_Homo sapiens_hsa049240.52779705
97Synaptic vesicle cycle_Homo sapiens_hsa047210.52306026
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.52082866
99Fatty acid degradation_Homo sapiens_hsa000710.50874400
100Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50397836
101MAPK signaling pathway_Homo sapiens_hsa040100.50183392
102Sulfur metabolism_Homo sapiens_hsa009200.49329659
103Epstein-Barr virus infection_Homo sapiens_hsa051690.48098795
104Renin-angiotensin system_Homo sapiens_hsa046140.45771622
105Oxytocin signaling pathway_Homo sapiens_hsa049210.43634216
106Influenza A_Homo sapiens_hsa051640.43245241
107Bile secretion_Homo sapiens_hsa049760.42389756
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42217239
109Hedgehog signaling pathway_Homo sapiens_hsa043400.41515962
110Base excision repair_Homo sapiens_hsa034100.40268501
111Tight junction_Homo sapiens_hsa045300.40012043
112Thyroid hormone synthesis_Homo sapiens_hsa049180.38886479
113Systemic lupus erythematosus_Homo sapiens_hsa053220.37516452
114Non-homologous end-joining_Homo sapiens_hsa034500.37183897
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36708718
116Insulin secretion_Homo sapiens_hsa049110.36364087
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.35731654
118Estrogen signaling pathway_Homo sapiens_hsa049150.35142262
119Thyroid hormone signaling pathway_Homo sapiens_hsa049190.34063436
120Vitamin digestion and absorption_Homo sapiens_hsa049770.33162038
121Calcium signaling pathway_Homo sapiens_hsa040200.31661043
122Ovarian steroidogenesis_Homo sapiens_hsa049130.31145509
123Tryptophan metabolism_Homo sapiens_hsa003800.31098066
124Nucleotide excision repair_Homo sapiens_hsa034200.30767388
125Alcoholism_Homo sapiens_hsa050340.29662941
126Endocytosis_Homo sapiens_hsa041440.29339824
127Cocaine addiction_Homo sapiens_hsa050300.27403563
128Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.25838760
129Protein digestion and absorption_Homo sapiens_hsa049740.25575809
130Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.24568905
131Pancreatic secretion_Homo sapiens_hsa049720.23922304
132Legionellosis_Homo sapiens_hsa051340.23792855
133Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.23035281
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22562412
135Sphingolipid metabolism_Homo sapiens_hsa006000.22082314
136Long-term potentiation_Homo sapiens_hsa047200.21728056
137Peroxisome_Homo sapiens_hsa041460.20411817
138Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.20280628
139Adipocytokine signaling pathway_Homo sapiens_hsa049200.19227625
140Salivary secretion_Homo sapiens_hsa049700.18797761
141AMPK signaling pathway_Homo sapiens_hsa041520.18756683
142cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18470261
143N-Glycan biosynthesis_Homo sapiens_hsa005100.18000999
144Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17962761
145Circadian rhythm_Homo sapiens_hsa047100.17872334
146Gastric acid secretion_Homo sapiens_hsa049710.17349742
147Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17288802

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