TMED10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1signal peptide processing (GO:0006465)8.80026990
2* Golgi transport vesicle coating (GO:0048200)7.88831327
3* COPI coating of Golgi vesicle (GO:0048205)7.88831327
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.02603630
5protein retention in ER lumen (GO:0006621)6.41510965
6protein maturation by protein folding (GO:0022417)5.43699675
7sequestering of metal ion (GO:0051238)5.17645978
8regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.74092256
9ER overload response (GO:0006983)4.69698199
10desmosome organization (GO:0002934)4.67340306
11* COPII vesicle coating (GO:0048208)4.54293676
12activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.46277087
13ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.37477212
14central nervous system myelination (GO:0022010)4.36529877
15axon ensheathment in central nervous system (GO:0032291)4.36529877
16positive regulation of nuclease activity (GO:0032075)4.30390188
17* retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.14389167
18exocrine pancreas development (GO:0031017)4.13129997
19amyloid precursor protein catabolic process (GO:0042987)4.07242177
20endoplasmic reticulum unfolded protein response (GO:0030968)4.04292527
21endocrine pancreas development (GO:0031018)4.01420486
22cellular response to unfolded protein (GO:0034620)3.97724323
23regulation of nuclease activity (GO:0032069)3.94131955
24cell adhesion mediated by integrin (GO:0033627)3.92988764
25protein N-linked glycosylation via asparagine (GO:0018279)3.90738190
26cellular response to topologically incorrect protein (GO:0035967)3.87465414
27nucleotide transmembrane transport (GO:1901679)3.87015702
28peptidyl-asparagine modification (GO:0018196)3.83858044
29peptide hormone processing (GO:0016486)3.80032795
30fatty acid elongation (GO:0030497)3.77845249
31amyloid precursor protein metabolic process (GO:0042982)3.75979258
32bundle of His cell to Purkinje myocyte communication (GO:0086069)3.75293285
33ER-nucleus signaling pathway (GO:0006984)3.71777035
34protein N-linked glycosylation (GO:0006487)3.70909825
35skin morphogenesis (GO:0043589)3.70684906
36hemidesmosome assembly (GO:0031581)3.67994316
37GDP-mannose metabolic process (GO:0019673)3.54013314
38eosinophil chemotaxis (GO:0048245)3.52236439
39keratan sulfate catabolic process (GO:0042340)3.48665760
40response to endoplasmic reticulum stress (GO:0034976)3.44744070
41regulation of sister chromatid cohesion (GO:0007063)3.34390609
42* ER to Golgi vesicle-mediated transport (GO:0006888)3.28124105
43glandular epithelial cell differentiation (GO:0002067)3.26292630
44peptide catabolic process (GO:0043171)3.26136801
45regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.24137102
46type B pancreatic cell development (GO:0003323)3.23526543
47regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.21870775
48response to unfolded protein (GO:0006986)3.21342825
49* vesicle coating (GO:0006901)3.21297579
50response to lipoprotein particle (GO:0055094)3.19717802
51regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.17935178
52membrane protein ectodomain proteolysis (GO:0006509)3.17383792
53nucleotide-sugar biosynthetic process (GO:0009226)3.14953855
54leukocyte migration involved in inflammatory response (GO:0002523)3.14148266
55response to topologically incorrect protein (GO:0035966)3.13190091
56eosinophil migration (GO:0072677)3.09067488
57negative regulation of complement activation (GO:0045916)3.08916827
58creatine metabolic process (GO:0006600)3.05471643
59neutrophil activation involved in immune response (GO:0002283)3.01252734
60UDP-N-acetylglucosamine metabolic process (GO:0006047)2.99591103
61surfactant homeostasis (GO:0043129)2.97329512
62myelin maintenance (GO:0043217)2.96558700
63negative regulation of JUN kinase activity (GO:0043508)2.96167313
64magnesium ion transport (GO:0015693)2.95562758
65negative regulation of protein activation cascade (GO:2000258)2.94198859
66response to redox state (GO:0051775)2.94087901
67adhesion of symbiont to host cell (GO:0044650)2.93931570
68virion attachment to host cell (GO:0019062)2.93931570
69branching involved in mammary gland duct morphogenesis (GO:0060444)2.92831960
70cholesterol biosynthetic process (GO:0006695)2.92476429
71cell redox homeostasis (GO:0045454)2.89905885
72negative regulation of Ras GTPase activity (GO:0034261)2.89579433
73negative regulation of glycoprotein biosynthetic process (GO:0010561)2.87873754
74intestinal epithelial cell development (GO:0060576)2.86456620
75regulation of type B pancreatic cell apoptotic process (GO:2000674)2.85946633
76positive regulation of mitotic sister chromatid separation (GO:1901970)2.85551860
77positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.85551860
78positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.85551860
79glycolipid catabolic process (GO:0019377)2.85349274
80peptidyl-proline hydroxylation (GO:0019511)2.83782327
81regulation of mononuclear cell migration (GO:0071675)2.79011108
82regulation of metalloenzyme activity (GO:0048552)2.77665264
83regulation of transforming growth factor beta2 production (GO:0032909)2.77010715
84dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.76639049
85regulation of extracellular matrix disassembly (GO:0010715)2.76331157
86alpha-linolenic acid metabolic process (GO:0036109)2.75937831
87long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.75163208
884-hydroxyproline metabolic process (GO:0019471)2.74500197
89positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.73745236
90glycosylceramide metabolic process (GO:0006677)2.71698095
91peptide metabolic process (GO:0006518)2.71397004
92toxin metabolic process (GO:0009404)2.69534765
93negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.68983021
94L-serine transport (GO:0015825)2.66839572
95adhesion of symbiont to host (GO:0044406)2.63189770
96protein hydroxylation (GO:0018126)2.62686360
97gap junction assembly (GO:0016264)2.62487561
98mannosylation (GO:0097502)2.62290278
99apoptotic cell clearance (GO:0043277)2.61835645
100ensheathment of neurons (GO:0007272)2.61398511
101axon ensheathment (GO:0008366)2.61398511
102regulation of phospholipase A2 activity (GO:0032429)2.61179043
103branch elongation of an epithelium (GO:0060602)2.57533711
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.57493641
105cellular zinc ion homeostasis (GO:0006882)2.57259538
106myelination (GO:0042552)2.55730716
107sterol biosynthetic process (GO:0016126)2.55508431
108regulation of glucocorticoid metabolic process (GO:0031943)2.55328407
109ceramide catabolic process (GO:0046514)2.55037125
110regulation of complement activation (GO:0030449)2.53985281
111nucleoside diphosphate catabolic process (GO:0009134)2.52766945
112astrocyte differentiation (GO:0048708)2.52157936
113sequestering of extracellular ligand from receptor (GO:0035581)2.51502491
114cellular response to vitamin D (GO:0071305)2.51329517
115regulation of integrin-mediated signaling pathway (GO:2001044)2.50816085
116fucose metabolic process (GO:0006004)2.50441223
117regulation of cardioblast differentiation (GO:0051890)2.50424215
118glutamine family amino acid biosynthetic process (GO:0009084)2.49718496
119transcytosis (GO:0045056)2.48916751
120regulation of autophagic vacuole assembly (GO:2000785)2.47802903
121regulation of protein activation cascade (GO:2000257)2.47333846
122glycosphingolipid catabolic process (GO:0046479)2.46794501
123membrane protein proteolysis (GO:0033619)2.46622072
124glomerular basement membrane development (GO:0032836)2.46585042
125negative regulation of glycoprotein metabolic process (GO:1903019)2.46145975
126regulation of cholesterol biosynthetic process (GO:0045540)2.45923012
127cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.44705488
128negative regulation of humoral immune response (GO:0002921)2.44585867
129NADH metabolic process (GO:0006734)2.44132099
130chondrocyte development (GO:0002063)2.43816678
131iron ion import (GO:0097286)2.43729561
132nucleotide transport (GO:0006862)2.43516593
133eye photoreceptor cell differentiation (GO:0001754)2.42766830
134photoreceptor cell differentiation (GO:0046530)2.42766830
135glandular epithelial cell development (GO:0002068)2.41929197
136basement membrane organization (GO:0071711)2.41052369
137* Golgi organization (GO:0007030)2.41025684
138cellular copper ion homeostasis (GO:0006878)2.40797217
139epithelial cell-cell adhesion (GO:0090136)2.40627266
140protein autoprocessing (GO:0016540)2.40221881
141maintenance of protein localization in organelle (GO:0072595)2.39908926
142nucleotide-sugar metabolic process (GO:0009225)2.39707253
143negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.39698299
144peptidyl-lysine dimethylation (GO:0018027)2.39431937
145carbohydrate derivative transport (GO:1901264)2.39103524
146sphingosine metabolic process (GO:0006670)2.38819574
147tricarboxylic acid cycle (GO:0006099)2.37759675
148pyrimidine-containing compound transmembrane transport (GO:0072531)2.36638689
149collagen fibril organization (GO:0030199)2.36146955
150fatty-acyl-CoA biosynthetic process (GO:0046949)2.36132299
151axis elongation (GO:0003401)2.34375218
152retina vasculature morphogenesis in camera-type eye (GO:0061299)2.33979510
153phosphatidylserine acyl-chain remodeling (GO:0036150)2.32879773
154regulation of hydrogen peroxide-induced cell death (GO:1903205)2.32543972
155regulation of steroid hormone biosynthetic process (GO:0090030)2.32305480
156regulation of transforming growth factor beta1 production (GO:0032908)2.31359110
157biotin metabolic process (GO:0006768)2.30781664
158fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.29895924
159negative regulation of protein localization to plasma membrane (GO:1903077)2.28896065
160dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.28747472
161positive regulation of hormone metabolic process (GO:0032352)2.28738327
162positive regulation of hormone biosynthetic process (GO:0046886)2.28130102
163protein carboxylation (GO:0018214)2.27991057
164peptidyl-glutamic acid carboxylation (GO:0017187)2.27991057
165extracellular regulation of signal transduction (GO:1900115)2.25204766
166extracellular negative regulation of signal transduction (GO:1900116)2.25204766
167type B pancreatic cell proliferation (GO:0044342)2.25129150
168lipid particle organization (GO:0034389)2.25067532
169proline biosynthetic process (GO:0006561)2.24637638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.46106176
2ZNF263_19887448_ChIP-Seq_K562_Human3.37707093
3PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.26848971
4TRIM28_21343339_ChIP-Seq_HEK293_Human2.98778397
5* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75894093
6AR_21909140_ChIP-Seq_LNCAP_Human2.56842235
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.56215289
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.55153367
9HIF1A_21447827_ChIP-Seq_MCF-7_Human2.53530550
10GATA1_22025678_ChIP-Seq_K562_Human2.52663931
11STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.47097189
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.45380072
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37624561
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34323693
15* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.30154984
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21129314
17SOX2_27498859_Chip-Seq_STOMACH_Mouse2.16249069
18CLOCK_20551151_ChIP-Seq_293T_Human2.15714002
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.14495175
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08209895
21* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.04567936
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.01357588
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01300601
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.00917466
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00290795
26SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.99398477
27NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97084989
28SOX2_20726797_ChIP-Seq_SW620_Human1.94439326
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.76656937
30* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.74313859
31* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.74313859
32* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.71282834
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.66573394
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.66009181
35* EST1_17652178_ChIP-ChIP_JURKAT_Human1.64532616
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63254402
37FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.63145745
38CDX2_20551321_ChIP-Seq_CACO-2_Human1.62986096
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62751449
40FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.62646644
41POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59956427
42IRF8_21731497_ChIP-ChIP_J774_Mouse1.59377238
43* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.56809139
44CJUN_26792858_Chip-Seq_BT549_Human1.56132512
45PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.51865538
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.50554982
47KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49646102
48FOXM1_26456572_ChIP-Seq_MCF-7_Human1.49087134
49SOX9_24532713_ChIP-Seq_HFSC_Mouse1.48164571
50ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46973477
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.46122584
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45230632
53ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.44642416
54* GATA4_25053715_ChIP-Seq_YYC3_Human1.44527927
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.44251247
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41993811
57CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.40830271
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.39639113
59* ESR1_21235772_ChIP-Seq_MCF-7_Human1.38414524
60* TFEB_21752829_ChIP-Seq_HELA_Human1.37136255
61* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.36888110
62BRD4_25478319_ChIP-Seq_HGPS_Human1.35325883
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.34466526
64PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34243134
65FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33841129
66* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33415186
67ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.33296322
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.32941369
69P63_26484246_Chip-Seq_KERATINOCYTES_Human1.32080521
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.32008950
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31069549
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.30517717
73* SRF_21415370_ChIP-Seq_HL-1_Mouse1.30395353
74ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.28090093
75MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.27623123
76WT1_19549856_ChIP-ChIP_CCG9911_Human1.27538944
77TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.27429106
78CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26649846
79* ETS1_20019798_ChIP-Seq_JURKAT_Human1.26612032
80* TBX20_22328084_ChIP-Seq_HEART_Mouse1.25615597
81* TBX20_22080862_ChIP-Seq_HEART_Mouse1.25615597
82AHR_22903824_ChIP-Seq_MCF-7_Human1.24373999
83RXR_22158963_ChIP-Seq_LIVER_Mouse1.24075886
84GATA3_24758297_ChIP-Seq_MCF-7_Human1.22842052
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.22085645
86PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21856659
87* SOX17_20123909_ChIP-Seq_XEN_Mouse1.20223893
88CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19885421
89* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.19708942
90* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18588012
91NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18568305
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18568305
93* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.18544822
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.18337494
95* IRF8_27001747_Chip-Seq_BMDM_Mouse1.17713853
96TBX5_21415370_ChIP-Seq_HL-1_Mouse1.17503288
97HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17106133
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16955958
99E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15868186
100SPI1_23547873_ChIP-Seq_NB4_Human1.14753501
101AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.14646630
102PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.14037888
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.14022789
104* EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12672873
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12667913
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12231278
107TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11911509
108DCP1A_22483619_ChIP-Seq_HELA_Human1.10403691
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10156576
110SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.09631050
111FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08911915
112SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.08847173
113* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08110391
114SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07849310
115* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07444402
116PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.07105990
117TCF4_18268006_ChIP-ChIP_LS174T_Human1.06997353
118GATA4_21415370_ChIP-Seq_HL-1_Mouse1.06916594
119FOXA2_19822575_ChIP-Seq_HepG2_Human1.06625069
120* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.06593655
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06101989
122BP1_19119308_ChIP-ChIP_Hs578T_Human1.05891602
123HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04714733
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04555781
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04186388
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03994270
127EOMES_21245162_ChIP-Seq_HESCs_Human1.03424231
128PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03277553
129GATA1_19941826_ChIP-Seq_K562_Human1.03090162
130CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02694777
131TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02550174
132KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01091333
133CHD1_26751641_Chip-Seq_LNCaP_Human1.01025073
134* TP63_23658742_ChIP-Seq_EP156T_Human1.00956224
135CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00715349
136FOXA1_25552417_ChIP-Seq_VCAP_Human1.00396007
137PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00080905
138RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.99543324
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98577615
140PCGF2_27294783_Chip-Seq_ESCs_Mouse0.98431873
141TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97993734
142MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97645714
143VDR_24763502_ChIP-Seq_THP-1_Human0.97402404
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.97058944
145* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96346549
146GATA6_25053715_ChIP-Seq_YYC3_Human0.95211805
147* ELK1_19687146_ChIP-ChIP_HELA_Human0.93786238
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92584754
149NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92241618
150* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91473685
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.91250635
152EGR1_19374776_ChIP-ChIP_THP-1_Human0.91187442
153GABP_19822575_ChIP-Seq_HepG2_Human0.91119625
154* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89977453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.55263735
2MP0005058_abnormal_lysosome_morphology4.49891210
3MP0003195_calcinosis3.66947449
4MP0008438_abnormal_cutaneous_collagen3.18832493
5MP0006054_spinal_hemorrhage3.18460628
6MP0004043_abnormal_pH_regulation3.02176509
7MP0003183_abnormal_peptide_metabolism2.97998882
8MP0010352_gastrointestinal_tract_polyps2.76487242
9MP0003941_abnormal_skin_development2.75259515
10MP0000566_synostosis2.60351518
11MP0002877_abnormal_melanocyte_morpholog2.59099945
12MP0005257_abnormal_intraocular_pressure2.57602572
13MP0000920_abnormal_myelination2.54272439
14MP0005220_abnormal_exocrine_pancreas2.53880652
15MP0000013_abnormal_adipose_tissue2.48097733
16MP0010368_abnormal_lymphatic_system2.43962864
17MP0002693_abnormal_pancreas_physiology2.24920367
18MP0003172_abnormal_lysosome_physiology2.23675246
19MP0003705_abnormal_hypodermis_morpholog2.14014992
20MP0010386_abnormal_urinary_bladder2.09111024
21MP0004264_abnormal_extraembryonic_tissu2.02551206
22MP0001666_abnormal_nutrient_absorption1.96556587
23MP0001944_abnormal_pancreas_morphology1.94884774
24MP0003806_abnormal_nucleotide_metabolis1.93236494
25MP0004272_abnormal_basement_membrane1.80529782
26MP0003690_abnormal_glial_cell1.80335672
27MP0003300_gastrointestinal_ulcer1.79199522
28MP0000003_abnormal_adipose_tissue1.71064200
29MP0005408_hypopigmentation1.70398670
30MP0003186_abnormal_redox_activity1.66804798
31MP0009643_abnormal_urine_homeostasis1.66388026
32MP0002933_joint_inflammation1.65143276
33MP0001542_abnormal_bone_strength1.60797472
34MP0001533_abnormal_skeleton_physiology1.59922305
35MP0002796_impaired_skin_barrier1.59159099
36MP0000462_abnormal_digestive_system1.58725939
37MP0009840_abnormal_foam_cell1.58350824
38MP0005379_endocrine/exocrine_gland_phen1.57408890
39MP0000467_abnormal_esophagus_morphology1.55692664
40MP0003868_abnormal_feces_composition1.54103032
41MP0003950_abnormal_plasma_membrane1.53096731
42MP0002295_abnormal_pulmonary_circulatio1.51573677
43MP0009780_abnormal_chondrocyte_physiolo1.50245850
44MP0005083_abnormal_biliary_tract1.49737055
45MP0003191_abnormal_cellular_cholesterol1.46861577
46MP0002896_abnormal_bone_mineralization1.40185476
47MP0005365_abnormal_bile_salt1.40091681
48MP0005503_abnormal_tendon_morphology1.39099879
49MP0004134_abnormal_chest_morphology1.34242817
50MP0000627_abnormal_mammary_gland1.31357650
51MP0001756_abnormal_urination1.30968441
52MP0003283_abnormal_digestive_organ1.29996756
53MP0005248_abnormal_Harderian_gland1.29574551
54MP0002909_abnormal_adrenal_gland1.27617585
55MP0000377_abnormal_hair_follicle1.26497328
56MP0001915_intracranial_hemorrhage1.25695654
57MP0000613_abnormal_salivary_gland1.25213993
58MP0003634_abnormal_glial_cell1.23410066
59MP0009384_cardiac_valve_regurgitation1.23191499
60MP0003724_increased_susceptibility_to1.23070434
61MP0002876_abnormal_thyroid_physiology1.22076350
62MP0003453_abnormal_keratinocyte_physiol1.21828014
63MP0005501_abnormal_skin_physiology1.21036225
64MP0003795_abnormal_bone_structure1.20998823
65MP0005623_abnormal_meninges_morphology1.19928870
66MP0005275_abnormal_skin_tensile1.17432017
67MP0006082_CNS_inflammation1.14059938
68MP0003091_abnormal_cell_migration1.13786014
69MP0005310_abnormal_salivary_gland1.13057923
70MP0004019_abnormal_vitamin_homeostasis1.12570824
71MP0002419_abnormal_innate_immunity1.12423279
72MP0002090_abnormal_vision1.12318532
73MP0000465_gastrointestinal_hemorrhage1.12275379
74MP0000762_abnormal_tongue_morphology1.10537527
75MP0001216_abnormal_epidermal_layer1.08519951
76MP0001849_ear_inflammation1.07037870
77MP0005636_abnormal_mineral_homeostasis1.05687912
78MP0005390_skeleton_phenotype1.05653043
79MP0005171_absent_coat_pigmentation1.04857283
80MP0003011_delayed_dark_adaptation1.03913736
81MP0001765_abnormal_ion_homeostasis1.03390189
82MP0002148_abnormal_hypersensitivity_rea1.02084204
83MP0001661_extended_life_span1.01400807
84MP0004782_abnormal_surfactant_physiolog1.01202988
85MP0001958_emphysema0.98058203
86MP0003436_decreased_susceptibility_to0.97766192
87MP0002078_abnormal_glucose_homeostasis0.97552890
88MP0000604_amyloidosis0.97518532
89MP0000343_altered_response_to0.97239772
90MP0002998_abnormal_bone_remodeling0.96717025
91MP0002009_preneoplasia0.96540330
92MP0005508_abnormal_skeleton_morphology0.96431598
93MP0003329_amyloid_beta_deposits0.95727392
94MP0000534_abnormal_ureter_morphology0.95716931
95MP0003566_abnormal_cell_adhesion0.95491323
96MP0000678_abnormal_parathyroid_gland0.94694417
97MP0000579_abnormal_nail_morphology0.91861834
98MP0004233_abnormal_muscle_weight0.90838032
99MP0003115_abnormal_respiratory_system0.89951639
100MP0005197_abnormal_uvea_morphology0.89921904
101MP0002166_altered_tumor_susceptibility0.89779362
102MP0003959_abnormal_lean_body0.87941356
103MP0005164_abnormal_response_to0.87175386
104MP0000163_abnormal_cartilage_morphology0.86284007
105MP0001881_abnormal_mammary_gland0.85429273
106MP0010771_integument_phenotype0.84525040
107MP0002098_abnormal_vibrissa_morphology0.84040189
108MP0001299_abnormal_eye_distance/0.83901961
109MP0005409_darkened_coat_color0.83866398
110MP0010678_abnormal_skin_adnexa0.83581447
111MP0004858_abnormal_nervous_system0.83473736
112MP0001879_abnormal_lymphatic_vessel0.83444736
113MP0008004_abnormal_stomach_pH0.83235690
114MP0005084_abnormal_gallbladder_morpholo0.82989573
115MP0010329_abnormal_lipoprotein_level0.82449431
116MP0000681_abnormal_thyroid_gland0.82240373
117MP0003656_abnormal_erythrocyte_physiolo0.81287254
118MP0000537_abnormal_urethra_morphology0.79962869
119MP0002118_abnormal_lipid_homeostasis0.79437274
120MP0005375_adipose_tissue_phenotype0.79244819
121MP0001851_eye_inflammation0.78746141
122MP0000383_abnormal_hair_follicle0.78368410
123MP0000639_abnormal_adrenal_gland0.77998576
124MP0005000_abnormal_immune_tolerance0.77930686
125MP0000230_abnormal_systemic_arterial0.77881518
126MP0001845_abnormal_inflammatory_respons0.77452938
127MP0005332_abnormal_amino_acid0.77148909
128MP0005085_abnormal_gallbladder_physiolo0.76484255
129MP0005451_abnormal_body_composition0.75528960
130MP0009333_abnormal_splenocyte_physiolog0.74475817
131MP0003279_aneurysm0.74026273
132MP0000767_abnormal_smooth_muscle0.73515744
133MP0002060_abnormal_skin_morphology0.72032219
134MP0005023_abnormal_wound_healing0.70335896
135MP0008469_abnormal_protein_level0.69371583
136MP0002168_other_aberrant_phenotype0.68420383
137MP0001243_abnormal_dermal_layer0.68244138
138MP0001986_abnormal_taste_sensitivity0.68076281
139MP0005076_abnormal_cell_differentiation0.67960310
140MP0003866_abnormal_defecation0.66337033
141MP0001664_abnormal_digestion0.65544333
142MP0005165_increased_susceptibility_to0.64359813
143MP0000477_abnormal_intestine_morphology0.63971252
144MP0005330_cardiomyopathy0.63601670
145MP0001790_abnormal_immune_system0.63355211
146MP0005387_immune_system_phenotype0.63355211
147MP0000432_abnormal_head_morphology0.63051430
148MP0002115_abnormal_skeleton_extremities0.62804723
149MP0002139_abnormal_hepatobiliary_system0.62610124
150MP0005193_abnormal_anterior_eye0.62189822
151MP0009053_abnormal_anal_canal0.61453415
152MP0006072_abnormal_retinal_apoptosis0.60756563
153MP0002697_abnormal_eye_size0.60236054
154MP0000647_abnormal_sebaceous_gland0.60044428
155MP0009697_abnormal_copulation0.59547004

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)4.95561661
2Dysostosis multiplex (HP:0000943)4.62208267
3Hypoglycemic coma (HP:0001325)4.15760148
4Protrusio acetabuli (HP:0003179)3.98526549
5Urinary glycosaminoglycan excretion (HP:0003541)3.85327389
6Mucopolysacchariduria (HP:0008155)3.85327389
7Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.68655250
8Increased neuronal autofluorescent lipopigment (HP:0002074)3.66863172
9Hypoglycemic seizures (HP:0002173)3.65952382
10Hyperinsulinemic hypoglycemia (HP:0000825)3.62032947
11Increased cerebral lipofuscin (HP:0011813)3.57864239
12Right ventricular cardiomyopathy (HP:0011663)3.53226018
13Symptomatic seizures (HP:0011145)3.52237419
14Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45098547
15Abnormality of polysaccharide metabolism (HP:0011012)3.32566247
16Abnormality of glycosaminoglycan metabolism (HP:0004371)3.32566247
17Abnormality of mucopolysaccharide metabolism (HP:0011020)3.32566247
18Vascular tortuosity (HP:0004948)3.21898243
19Generalized aminoaciduria (HP:0002909)3.17195636
20Atrophic scars (HP:0001075)3.15525970
21Abnormality of liposaccharide metabolism (HP:0010968)3.13138356
22Abnormality of glycosphingolipid metabolism (HP:0004343)3.13138356
23Abnormality of glycolipid metabolism (HP:0010969)3.13138356
24Vertebral compression fractures (HP:0002953)3.10627889
25Epiphyseal dysplasia (HP:0002656)3.09301169
26Mitral stenosis (HP:0001718)3.06893634
27Arterial tortuosity (HP:0005116)3.05189825
28Beaking of vertebral bodies (HP:0004568)3.02936392
29Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.97207004
30Progressive neurologic deterioration (HP:0002344)2.94561164
31Asymmetry of the thorax (HP:0001555)2.92116234
32Cardiovascular calcification (HP:0011915)2.92007668
33Large for gestational age (HP:0001520)2.85922771
34Fat malabsorption (HP:0002630)2.80699513
35Vascular calcification (HP:0004934)2.79733045
36Abnormal pancreas size (HP:0012094)2.79195947
37Neurofibrillary tangles (HP:0002185)2.76309652
38Pancreatic islet-cell hyperplasia (HP:0004510)2.71201976
39Abnormal protein N-linked glycosylation (HP:0012347)2.69726791
40Abnormal protein glycosylation (HP:0012346)2.69726791
41Abnormal glycosylation (HP:0012345)2.69726791
42Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69726791
43Abnormality of the intrinsic pathway (HP:0010989)2.66996093
44Protuberant abdomen (HP:0001538)2.66434054
45Aortic dissection (HP:0002647)2.66166792
46Abnormality of dentin (HP:0010299)2.64675549
47Abnormality of endocrine pancreas physiology (HP:0012093)2.63956021
48Abnormality of the pancreatic islet cells (HP:0006476)2.63956021
49Short nail (HP:0001799)2.62246332
50Type I transferrin isoform profile (HP:0003642)2.61997850
51Cervical subluxation (HP:0003308)2.56692891
52Flat acetabular roof (HP:0003180)2.43040921
53Abnormal tarsal ossification (HP:0008369)2.41400901
54Wormian bones (HP:0002645)2.41084624
55Delayed epiphyseal ossification (HP:0002663)2.37489523
56Abnormality of the distal phalanges of the toes (HP:0010182)2.35961015
57Spondylolisthesis (HP:0003302)2.34399298
58Hyperglycemia (HP:0003074)2.34157825
59Disproportionate short-trunk short stature (HP:0003521)2.33285880
60Autoamputation (HP:0001218)2.31667982
61Retinal atrophy (HP:0001105)2.29273586
62Premature rupture of membranes (HP:0001788)2.28418811
63Ketoacidosis (HP:0001993)2.28245963
64Menstrual irregularities (HP:0000858)2.27997073
65Microglossia (HP:0000171)2.26939954
66Ovoid vertebral bodies (HP:0003300)2.25414860
67Abnormal foot bone ossification (HP:0010675)2.25401178
68Hypoplasia of the odontoid process (HP:0003311)2.23860357
69Pterygium (HP:0001059)2.23551745
70Back pain (HP:0003418)2.22403271
71Abnormality of aromatic amino acid family metabolism (HP:0004338)2.21165716
72Abnormality of carpal bone ossification (HP:0006257)2.21043281
73Abnormality of calcium-phosphate metabolism (HP:0100530)2.20737366
74Hepatosplenomegaly (HP:0001433)2.20243283
75Irregular vertebral endplates (HP:0003301)2.19347369
76Ankle contracture (HP:0006466)2.18034471
77Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.15794434
78Thoracolumbar scoliosis (HP:0002944)2.15146041
79Abnormality of macrophages (HP:0004311)2.12308888
80Abnormality of fatty-acid metabolism (HP:0004359)2.10975902
81Small epiphyses (HP:0010585)2.09815229
82Neuroendocrine neoplasm (HP:0100634)2.09565768
83Nonimmune hydrops fetalis (HP:0001790)2.08237797
84Abdominal distention (HP:0003270)2.07700296
85Pheochromocytoma (HP:0002666)2.07325311
86Hypokalemia (HP:0002900)2.07165524
87Metaphyseal irregularity (HP:0003025)2.06630656
88Fragile skin (HP:0001030)2.05479009
89Hyperparathyroidism (HP:0000843)2.05162113
90Intrahepatic cholestasis (HP:0001406)2.04726502
91Hypokinesia (HP:0002375)2.04429974
92Platyspondyly (HP:0000926)2.04201865
93Joint stiffness (HP:0001387)2.04149100
94Insulin-resistant diabetes mellitus (HP:0000831)2.03733244
95Axonal loss (HP:0003447)2.02965270
96Plantar hyperkeratosis (HP:0007556)2.01538711
97Papillary thyroid carcinoma (HP:0002895)2.00656929
98Poor head control (HP:0002421)2.00302201
99Flat capital femoral epiphysis (HP:0003370)2.00086574
100Testicular neoplasm (HP:0010788)1.98701360
101Pili torti (HP:0003777)1.98571977
102Late onset (HP:0003584)1.97707884
103Abnormality of the acetabulum (HP:0003170)1.95828297
104Abnormality of urine glucose concentration (HP:0011016)1.94287721
105Glycosuria (HP:0003076)1.94287721
106Absent frontal sinuses (HP:0002688)1.93831011
107Barrel-shaped chest (HP:0001552)1.93549137
108Neonatal short-limb short stature (HP:0008921)1.92336396
109Myoglobinuria (HP:0002913)1.91846678
110Abnormality of the vertebral endplates (HP:0005106)1.91407158
111Abnormality of oral frenula (HP:0000190)1.91102944
112Patchy hypopigmentation of hair (HP:0011365)1.90199091
113Termporal pattern (HP:0011008)1.89979273
114Insidious onset (HP:0003587)1.89979273
115Hepatic necrosis (HP:0002605)1.88980493
116Palmoplantar hyperkeratosis (HP:0000972)1.88928817
117Tetraparesis (HP:0002273)1.87393366
118Thyroid carcinoma (HP:0002890)1.86361663
119Steatorrhea (HP:0002570)1.86171296
120Segmental peripheral demyelination/remyelination (HP:0003481)1.86000687
121Popliteal pterygium (HP:0009756)1.85700373
122Follicular hyperkeratosis (HP:0007502)1.85008811
123Irregular epiphyses (HP:0010582)1.84757378
124Congenital ichthyosiform erythroderma (HP:0007431)1.84585381
125Periodontitis (HP:0000704)1.84303917
126Soft skin (HP:0000977)1.83439300
127Congenital glaucoma (HP:0001087)1.83432318
128Cerebral hypomyelination (HP:0006808)1.82980510
129Aplasia/hypoplasia of the uterus (HP:0008684)1.82714442
130Abnormality of the lumbar spine (HP:0100712)1.82415693
131Conjugated hyperbilirubinemia (HP:0002908)1.82262323
132Palmar hyperkeratosis (HP:0010765)1.82143154
133Lower limb hyperreflexia (HP:0002395)1.81283179
134Enlarged epiphyses (HP:0010580)1.80451287
135Generalized amyotrophy (HP:0003700)1.80410550
136Hypoplasia of the uterus (HP:0000013)1.78892543
137Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.78455966
138Ankyloglossia (HP:0010296)1.77124976
139Reduced antithrombin III activity (HP:0001976)1.76989088
140Aplasia/Hypoplasia involving the vertebral column (HP:0008518)1.76778808
141Abnormal delivery (HP:0001787)1.76732089
142Spinal cord lesions (HP:0100561)1.76316597
143Syringomyelia (HP:0003396)1.76316597
144Exocrine pancreatic insufficiency (HP:0001738)1.76273450
145Bladder diverticulum (HP:0000015)1.75916012
146Parakeratosis (HP:0001036)1.75650309
147Hypokalemic alkalosis (HP:0001949)1.75622343
148Interstitial pulmonary disease (HP:0006530)1.75475163
149Advanced eruption of teeth (HP:0006288)1.74842720
150Vertebral arch anomaly (HP:0008438)1.74221392
151Decreased circulating renin level (HP:0003351)1.73954857
152White forelock (HP:0002211)1.73622607
153Breech presentation (HP:0001623)1.72752410
154Pulmonary artery stenosis (HP:0004415)1.72719193
155Hyperammonemia (HP:0001987)1.71763500
156Episodic fever (HP:0001954)1.71026004
157J-shaped sella turcica (HP:0002680)1.70473599
158Osteolytic defects of the hand bones (HP:0009699)1.70240298
159Osteolytic defects of the phalanges of the hand (HP:0009771)1.70240298
160Premature skin wrinkling (HP:0100678)1.69997986
161Abnormality of the common coagulation pathway (HP:0010990)1.69522082
162Abnormality of the odontoid process (HP:0003310)1.69484519
163Abnormality of monocarboxylic acid metabolism (HP:0010996)1.69154832
164Deep venous thrombosis (HP:0002625)1.68613703
165Skin nodule (HP:0200036)1.67217376
166Orthostatic hypotension (HP:0001278)1.66789588
167Spinal cord compression (HP:0002176)1.66526710
168Abnormal hand bone ossification (HP:0010660)1.66448844
169Osteoarthritis (HP:0002758)1.66436196
170Abnormal ossification of hand bones (HP:0005921)1.66361583
171Coxa vara (HP:0002812)1.65773402
172Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.65748584
173Growth hormone excess (HP:0000845)1.65338428
174Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.64747684
175Vertebral hypoplasia (HP:0008417)1.64747684
176Reduced subcutaneous adipose tissue (HP:0003758)1.64449094
177Hyperphosphatemia (HP:0002905)1.64257926
178Elevated alkaline phosphatase (HP:0003155)1.63078691

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.34501110
2ERN13.52868632
3STK393.23688914
4EPHB13.11236972
5MKNK12.87370812
6MAPK152.85235785
7TAOK32.82709919
8MST42.79597028
9INSRR2.64872395
10WNK42.56399766
11PASK2.50745081
12PDGFRA2.44792613
13MET2.34807304
14IRAK32.30772838
15PBK2.22314980
16BCKDK2.21619870
17MAP3K122.21439709
18LATS12.18252840
19EIF2AK32.07945349
20LIMK12.01461096
21FER1.90192879
22PKN21.83921543
23MAP3K31.80915466
24MAP3K21.76896820
25FGFR41.74308072
26TAOK21.72749178
27IRAK41.70543992
28STK38L1.66599876
29TESK11.66343040
30PIK3CG1.65963914
31MAPKAPK31.48970612
32HIPK21.48278614
33TAOK11.42444827
34MAP2K21.41410585
35OXSR11.40636363
36ERBB41.39642332
37LMTK21.38546472
38MAPKAPK51.37222411
39PIM21.35968284
40FGFR31.35365027
41EIF2AK11.33020830
42BRSK21.30228576
43FRK1.27206053
44LATS21.26596060
45NEK11.25048545
46SCYL21.25022303
47RIPK11.24489153
48BCR1.24435924
49NTRK11.21327954
50NEK61.19827558
51TESK21.18439446
52PRKD31.17634141
53STK241.17622261
54TRPM71.13913727
55IRAK11.11600328
56EEF2K1.10855977
57NME21.07213088
58TRIB31.03649526
59FLT31.03459282
60EPHA30.98715843
61EPHA20.98105023
62CDK60.96687994
63UHMK10.96446474
64SRPK10.96059072
65KDR0.93671804
66JAK10.92683294
67LRRK20.92171171
68PTK60.91497121
69ZAP700.89072915
70ARAF0.88534489
71SIK10.87522698
72TTK0.85053486
73MYLK0.84955857
74BUB10.82495303
75BMPR1B0.80377254
76CSNK1A1L0.79615944
77STK30.78666722
78YES10.78568969
79CLK10.78155232
80NEK90.78046938
81RPS6KB20.74658541
82PTK20.73791078
83CSNK1G30.72938322
84CAMK2D0.72726170
85PAK30.72435502
86RET0.72243388
87PDGFRB0.71575208
88STK160.69786467
89MST1R0.69705134
90TTN0.69401441
91TBK10.69220697
92IRAK20.68104606
93ITK0.67651294
94NUAK10.66551878
95FGFR20.64968819
96ABL20.63318623
97MAP2K30.63241271
98MAP3K10.62706054
99PRKG20.62452676
100ILK0.61905769
101AKT30.60684895
102TGFBR20.59670997
103FGFR10.59456199
104WNK10.58996492
105CSK0.56020101
106CSNK1G10.54051709
107EPHB20.53188970
108PRKD10.53052114
109BTK0.52836502
110MAPKAPK20.52260882
111NLK0.51150818
112GSK3A0.49977401
113TEC0.49620824
114CAMKK20.49467168
115DDR20.48883875
116PRKCE0.46408576
117PDK20.45104600
118ERBB30.44991131
119TSSK60.44578743
120PIK3CA0.43954398
121TYK20.41235924
122MAP3K80.41229366
123MAP3K50.39290677
124PHKG20.39069340
125PHKG10.39069340
126PKN10.38526552
127IGF1R0.38276506
128PAK10.38265425
129CDC42BPA0.37950693
130BLK0.37696376
131ROCK20.37504907
132PAK20.36775032
133CSNK1A10.36449335
134RPS6KB10.35994371
135PAK40.35983731
136CAMK2G0.35914902
137KSR20.35483738
138RPS6KA50.35449303
139MUSK0.35398190
140STK100.34235905
141BRAF0.34177317
142WNK30.34125248
143ICK0.34091434
144JAK30.33776201
145DYRK1B0.32967679
146STK380.32110756
147PRKCH0.31165661
148AKT20.30681511
149DYRK1A0.28661257
150SRC0.26222772
151ACVR1B0.26074696
152MTOR0.25944541
153MAP3K60.24857777
154SMG10.24689447

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.27529260
2Maturity onset diabetes of the young_Homo sapiens_hsa049504.84176515
3Sulfur metabolism_Homo sapiens_hsa009203.62511975
4Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.30336376
5Lysosome_Homo sapiens_hsa041422.81061363
6Steroid biosynthesis_Homo sapiens_hsa001002.63140110
7Other glycan degradation_Homo sapiens_hsa005112.59386874
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.55334386
9Fatty acid elongation_Homo sapiens_hsa000622.39122127
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.25629026
11N-Glycan biosynthesis_Homo sapiens_hsa005102.17141342
12Vibrio cholerae infection_Homo sapiens_hsa051101.99589737
13Folate biosynthesis_Homo sapiens_hsa007901.84957518
14Sphingolipid metabolism_Homo sapiens_hsa006001.73677186
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.66816309
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60282703
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.56348450
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55867483
19Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.55680036
20Vitamin B6 metabolism_Homo sapiens_hsa007501.51760446
21beta-Alanine metabolism_Homo sapiens_hsa004101.46533546
22Complement and coagulation cascades_Homo sapiens_hsa046101.43358408
23Oxidative phosphorylation_Homo sapiens_hsa001901.40405070
24Histidine metabolism_Homo sapiens_hsa003401.39563620
25Carbon metabolism_Homo sapiens_hsa012001.35461615
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.34223950
27Proteasome_Homo sapiens_hsa030501.33404876
28Ether lipid metabolism_Homo sapiens_hsa005651.29160835
29Pyruvate metabolism_Homo sapiens_hsa006201.26839767
30Arachidonic acid metabolism_Homo sapiens_hsa005901.23174895
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23080744
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21537563
33Linoleic acid metabolism_Homo sapiens_hsa005911.20220193
34Arginine biosynthesis_Homo sapiens_hsa002201.20159407
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.18761442
36Phenylalanine metabolism_Homo sapiens_hsa003601.16040226
37Protein digestion and absorption_Homo sapiens_hsa049741.15039378
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.15007786
39Primary bile acid biosynthesis_Homo sapiens_hsa001201.14059199
40Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13856427
41Glutathione metabolism_Homo sapiens_hsa004801.13823446
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12886877
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.12487785
44Pancreatic secretion_Homo sapiens_hsa049721.11143764
45Phagosome_Homo sapiens_hsa041451.09152503
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07566460
47Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98184888
48Regulation of autophagy_Homo sapiens_hsa041400.97427563
49Parkinsons disease_Homo sapiens_hsa050120.96215546
50PPAR signaling pathway_Homo sapiens_hsa033200.96006926
51Arginine and proline metabolism_Homo sapiens_hsa003300.95972295
52Thyroid cancer_Homo sapiens_hsa052160.94996440
53Biosynthesis of amino acids_Homo sapiens_hsa012300.94717737
54Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.93251289
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92636397
56Adherens junction_Homo sapiens_hsa045200.91136588
57Fat digestion and absorption_Homo sapiens_hsa049750.90822645
58Galactose metabolism_Homo sapiens_hsa000520.89314715
59Proteoglycans in cancer_Homo sapiens_hsa052050.86256575
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.85279330
61Caffeine metabolism_Homo sapiens_hsa002320.85101105
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84317198
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84221698
64Chemical carcinogenesis_Homo sapiens_hsa052040.80993599
65Lysine degradation_Homo sapiens_hsa003100.80909647
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.80349678
67Alzheimers disease_Homo sapiens_hsa050100.79885632
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.77295571
69Legionellosis_Homo sapiens_hsa051340.77102769
70ECM-receptor interaction_Homo sapiens_hsa045120.76159276
71Antigen processing and presentation_Homo sapiens_hsa046120.75220682
72Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74595544
73Renin-angiotensin system_Homo sapiens_hsa046140.74289061
74Retinol metabolism_Homo sapiens_hsa008300.72753990
75Malaria_Homo sapiens_hsa051440.69840295
76Rheumatoid arthritis_Homo sapiens_hsa053230.69290103
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.69282438
78Small cell lung cancer_Homo sapiens_hsa052220.68099758
79Bile secretion_Homo sapiens_hsa049760.66912211
80Starch and sucrose metabolism_Homo sapiens_hsa005000.66616347
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.65840163
82Selenocompound metabolism_Homo sapiens_hsa004500.65735317
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64186839
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.64142786
85Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63114576
86Thyroid hormone synthesis_Homo sapiens_hsa049180.62445622
87Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62173553
88Pertussis_Homo sapiens_hsa051330.58448093
89Cyanoamino acid metabolism_Homo sapiens_hsa004600.57647806
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57605672
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.57363277
92Metabolic pathways_Homo sapiens_hsa011000.54684098
93AMPK signaling pathway_Homo sapiens_hsa041520.54217576
94Circadian rhythm_Homo sapiens_hsa047100.54160784
95Fatty acid biosynthesis_Homo sapiens_hsa000610.53308347
96Fatty acid metabolism_Homo sapiens_hsa012120.53034887
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52998945
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.50926263
99Peroxisome_Homo sapiens_hsa041460.50613195
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.49581447
101Fatty acid degradation_Homo sapiens_hsa000710.49033401
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47952252
103Endometrial cancer_Homo sapiens_hsa052130.46265763
104Butanoate metabolism_Homo sapiens_hsa006500.44452831
105TGF-beta signaling pathway_Homo sapiens_hsa043500.43228997
106Prion diseases_Homo sapiens_hsa050200.42784554
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39777274
108Type I diabetes mellitus_Homo sapiens_hsa049400.39126487
109Huntingtons disease_Homo sapiens_hsa050160.38965614
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38286796
111Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37419752
112Vitamin digestion and absorption_Homo sapiens_hsa049770.36220076
113Collecting duct acid secretion_Homo sapiens_hsa049660.34939841
114Propanoate metabolism_Homo sapiens_hsa006400.34832481
115Leishmaniasis_Homo sapiens_hsa051400.32975319
116Tryptophan metabolism_Homo sapiens_hsa003800.31976526
117Tight junction_Homo sapiens_hsa045300.31387733
118Insulin secretion_Homo sapiens_hsa049110.31327659
119Mineral absorption_Homo sapiens_hsa049780.30545663
120Asthma_Homo sapiens_hsa053100.30508404
121Endocytosis_Homo sapiens_hsa041440.30032318
122Staphylococcus aureus infection_Homo sapiens_hsa051500.28208051
123Tyrosine metabolism_Homo sapiens_hsa003500.27004938
124Focal adhesion_Homo sapiens_hsa045100.26685089
125PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24963079
126RNA polymerase_Homo sapiens_hsa030200.24091157
127Amoebiasis_Homo sapiens_hsa051460.22750792
128Pentose phosphate pathway_Homo sapiens_hsa000300.20929095
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19923932
130Renal cell carcinoma_Homo sapiens_hsa052110.19887591
131Shigellosis_Homo sapiens_hsa051310.19134172
132ABC transporters_Homo sapiens_hsa020100.17919058
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17164390
134Sphingolipid signaling pathway_Homo sapiens_hsa040710.17086045
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16668552
136Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.16539981
137Fructose and mannose metabolism_Homo sapiens_hsa000510.16437877
138Glycerolipid metabolism_Homo sapiens_hsa005610.14900598
139Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.14573069

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