ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.78568164
2	regulation of mononuclear cell migration (GO:0071675)	9.47745587
3	regulation of sister chromatid cohesion (GO:0007063)	9.44907561
4	eosinophil migration (GO:0072677)	9.41955642
5	branch elongation of an epithelium (GO:0060602)	8.90455171
6	L-fucose catabolic process (GO:0042355)	8.15373062
7	fucose catabolic process (GO:0019317)	8.15373062
8	L-fucose metabolic process (GO:0042354)	8.15373062
9	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	7.98770950
10	positive regulation of chromosome segregation (GO:0051984)	7.84584281
11	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.74646862
12	vesicle fusion (GO:0006906)	7.55851102
13	coenzyme A biosynthetic process (GO:0015937)	7.41985767
14	peptidyl-lysine dimethylation (GO:0018027)	7.30724157
15	ribosomal small subunit assembly (GO:0000028)	7.14510143
16	autophagic vacuole fusion (GO:0000046)	6.98775847
17	axis elongation (GO:0003401)	6.91024065
18	organ growth (GO:0035265)	6.77606239
19	localization within membrane (GO:0051668)	6.61203937
20	macrophage chemotaxis (GO:0048246)	6.50208794
21	regulation of beta-amyloid formation (GO:1902003)	6.13813088
22	positive regulation of calcium ion import (GO:0090280)	5.91264893
23	negative regulation of GTP catabolic process (GO:0033125)	5.89762334
24	negative regulation of GTPase activity (GO:0034260)	5.89762334
25	establishment of mitotic spindle orientation (GO:0000132)	5.85160634
26	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.79165267
27	organelle membrane fusion (GO:0090174)	5.56437322
28	regulation of T cell receptor signaling pathway (GO:0050856)	5.54516493
29	monocyte chemotaxis (GO:0002548)	5.40157549
30	protein import into peroxisome matrix (GO:0016558)	5.36731328
31	non-recombinational repair (GO:0000726)	5.30910942
32	double-strand break repair via nonhomologous end joining (GO:0006303)	5.30910942
33	establishment of spindle orientation (GO:0051294)	5.15469222
34	establishment of mitotic spindle localization (GO:0040001)	5.14195506
35	3-UTR-mediated mRNA stabilization (GO:0070935)	5.08826872
36	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.92739380
37	histone H3-K9 methylation (GO:0051567)	4.84320518
38	acrosome assembly (GO:0001675)	4.78740217
39	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.78405952
40	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.78405952
41	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.78405952
42	negative regulation of circadian rhythm (GO:0042754)	4.76349981
43	seminiferous tubule development (GO:0072520)	4.70874727
44	pantothenate metabolic process (GO:0015939)	4.64354438
45	oxidative demethylation (GO:0070989)	4.63954034
46	positive chemotaxis (GO:0050918)	4.63018679
47	fucose metabolic process (GO:0006004)	4.59792903
48	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.58749670
49	organelle fusion (GO:0048284)	4.58503774
50	regulation of stem cell maintenance (GO:2000036)	4.54094245
51	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.39933149
52	coenzyme A metabolic process (GO:0015936)	4.29675040
53	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.29348187
54	protein targeting to lysosome (GO:0006622)	4.25151865
55	establishment of protein localization to vacuole (GO:0072666)	4.25151865
56	protein targeting to vacuole (GO:0006623)	4.25151865
57	fucosylation (GO:0036065)	4.23720930
58	regulation of autophagic vacuole assembly (GO:2000785)	4.21677052
59	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.13952105
60	membrane budding (GO:0006900)	4.08479539
61	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.06799350
62	histone H3-K9 modification (GO:0061647)	4.05773973
63	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.92346123
64	regulation of cellular amide metabolic process (GO:0034248)	3.92099186
65	negative regulation of nucleotide catabolic process (GO:0030812)	3.90201371
66	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.84317901
67	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.82774146
68	single-organism membrane fusion (GO:0044801)	3.82404996
69	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.79833728
70	establishment of spindle localization (GO:0051293)	3.75970420
71	COPI coating of Golgi vesicle (GO:0048205)	3.71556018
72	Golgi transport vesicle coating (GO:0048200)	3.71556018
73	COPII vesicle coating (GO:0048208)	3.71028806
74	ER to Golgi vesicle-mediated transport (GO:0006888)	3.69782021
75	negative regulation of nucleoside metabolic process (GO:0045978)	3.68158310
76	vesicle targeting (GO:0006903)	3.60196264
77	regulation of calcium ion import (GO:0090279)	3.57334979
78	DNA integration (GO:0015074)	3.50523224
79	regulation of vacuole organization (GO:0044088)	3.50323324
80	negative regulation of dendrite morphogenesis (GO:0050774)	3.44841966
81	protein localization to peroxisome (GO:0072662)	3.43379946
82	protein targeting to peroxisome (GO:0006625)	3.43379946
83	establishment of protein localization to peroxisome (GO:0072663)	3.43379946
84	metallo-sulfur cluster assembly (GO:0031163)	3.37576114
85	iron-sulfur cluster assembly (GO:0016226)	3.37576114
86	sodium-independent organic anion transport (GO:0043252)	3.36766532
87	imidazole-containing compound metabolic process (GO:0052803)	3.28171721
88	preassembly of GPI anchor in ER membrane (GO:0016254)	3.23653797
89	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.22591508
90	RNA methylation (GO:0001510)	3.21583612
91	peroxisomal transport (GO:0043574)	3.20591623
92	negative regulation of macroautophagy (GO:0016242)	3.19707006
93	protein prenylation (GO:0018342)	12.5543109
94	prenylation (GO:0097354)	12.5543109
95	negative regulation of Ras GTPase activity (GO:0034261)	12.4079234
96	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.1944788
97	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.1944788
98	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.1944788
99	eosinophil chemotaxis (GO:0048245)	10.4218392
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.0478107

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.71491897
2	VDR_22108803_ChIP-Seq_LS180_Human	5.89173521
3	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.78559180
4	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.17976403
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.93069767
6	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.90437695
7	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.75911685
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.71988903
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.53960065
10	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.53273222
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.32518064
12	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.19003724
13	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.09453088
14	GATA1_22025678_ChIP-Seq_K562_Human	12.2836885
15	RXR_22108803_ChIP-Seq_LS180_Human	1.86189337
16	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.85715416
17	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.85715416
18	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.77183200
19	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.62032117
20	TAF15_26573619_Chip-Seq_HEK293_Human	1.60061314
21	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.58854143
22	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.58854143
23	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.58854143
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58124113
25	BCAT_22108803_ChIP-Seq_LS180_Human	1.56245995
26	GBX2_23144817_ChIP-Seq_PC3_Human	1.43406821
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.42180355
28	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.37116208
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.34122089
30	TP53_16413492_ChIP-PET_HCT116_Human	1.33950600
31	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27471883
32	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.19041614
33	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.18972484
34	IRF1_19129219_ChIP-ChIP_H3396_Human	1.18424395
35	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.14077802
36	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.13849758
37	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.09467138
38	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.07704580
39	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.05805069
40	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.05425573
41	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	1.01906601
42	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.00260619
43	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.99838150
44	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.99504418
45	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.96249616
46	RUNX_20019798_ChIP-Seq_JUKART_Human	0.95916991
47	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.95661734
48	* GATA3_26560356_Chip-Seq_TH1_Human	0.95123233
49	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.92814978
50	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.90717517
51	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.89861794
52	CTCF_21964334_Chip-Seq_Bcells_Human	0.87779111
53	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.85026355
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.83556536
55	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.81426826
56	ZNF274_21170338_ChIP-Seq_K562_Hela	0.81238945
57	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.80310303
58	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.78389812
59	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.78253135
60	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.78205436
61	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.77622564
62	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.77338295
63	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.76442334
64	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.73060324
65	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.72081135
66	GATA1_19941826_ChIP-Seq_K562_Human	0.72013234
67	FUS_26573619_Chip-Seq_HEK293_Human	0.68431846
68	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.68162514
69	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.66885803
70	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.64976734
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.63095885
72	TP53_22573176_ChIP-Seq_HFKS_Human	0.62973608
73	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.60666188
74	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.60064892
75	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.59420116
76	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	0.59009268
77	P300_19829295_ChIP-Seq_ESCs_Human	0.58977514
78	HTT_18923047_ChIP-ChIP_STHdh_Human	0.58967963
79	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.58646611
80	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.57860383
81	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	0.56883887
82	TCF3_18692474_ChIP-Seq_MEFs_Mouse	0.56776010
83	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.56522855
84	MEF2A_21415370_ChIP-Seq_HL-1_Mouse	0.55761039
85	TCF4_22108803_ChIP-Seq_LS180_Human	0.55664595
86	STAT1_20625510_ChIP-Seq_HELA_Human	0.55164247
87	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.53842102
88	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.53714003
89	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.53379813
90	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.52658450
91	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	0.51892437
92	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.51358909
93	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.51081984
94	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.51033737
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.51009511
96	SOX2_21211035_ChIP-Seq_LN229_Gbm	0.50682801
97	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.50218920
98	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.50183787
99	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.49926501
100	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.49599123

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.67581163
2	MP0006082_CNS_inflammation	5.24243539
3	MP0000467_abnormal_esophagus_morphology	3.53003444
4	MP0001664_abnormal_digestion	3.22433022
5	MP0001663_abnormal_digestive_system	3.02069251
6	MP0003115_abnormal_respiratory_system	2.83114063
7	MP0001919_abnormal_reproductive_system	2.69809097
8	MP0000383_abnormal_hair_follicle	2.68695501
9	MP0002751_abnormal_autonomic_nervous	2.68134867
10	MP0005381_digestive/alimentary_phenotyp	2.41743589
11	MP0000566_synostosis	12.9674327
12	MP0000534_abnormal_ureter_morphology	1.85840508
13	MP0010678_abnormal_skin_adnexa	1.85736551
14	MP0005166_decreased_susceptibility_to	1.82413122
15	MP0002876_abnormal_thyroid_physiology	1.74734086
16	MP0001915_intracranial_hemorrhage	1.73400506
17	MP0003453_abnormal_keratinocyte_physiol	1.73146495
18	MP0003937_abnormal_limbs/digits/tail_de	1.73117426
19	MP0000428_abnormal_craniofacial_morphol	1.65918335
20	MP0005389_reproductive_system_phenotype	1.54658284
21	MP0005076_abnormal_cell_differentiation	1.46934885
22	MP0005397_hematopoietic_system_phenotyp	1.38275811
23	MP0001545_abnormal_hematopoietic_system	1.38275811
24	MP0001286_abnormal_eye_development	1.33211901
25	MP0005501_abnormal_skin_physiology	1.17225317
26	MP0001293_anophthalmia	1.14279858
27	MP0000490_abnormal_crypts_of	1.00423066
28	MP0000858_altered_metastatic_potential	0.98964340
29	MP0003763_abnormal_thymus_physiology	0.92071291
30	MP0002109_abnormal_limb_morphology	0.89460930
31	MP0000026_abnormal_inner_ear	0.86274602
32	MP0002115_abnormal_skeleton_extremities	0.84213263
33	MP0003329_amyloid_beta_deposits	0.83295056
34	MP0003942_abnormal_urinary_system	0.82973633
35	MP0003283_abnormal_digestive_organ	0.82748620
36	MP0000470_abnormal_stomach_morphology	0.82714964
37	MP0002019_abnormal_tumor_incidence	0.81060099
38	MP0000358_abnormal_cell_content/	0.77712270
39	MP0001963_abnormal_hearing_physiology	0.73525856
40	MP0005023_abnormal_wound_healing	0.72650709
41	MP0005197_abnormal_uvea_morphology	0.72624927
42	MP0010155_abnormal_intestine_physiology	0.72407755
43	MP0000477_abnormal_intestine_morphology	0.72271251
44	MP0001764_abnormal_homeostasis	0.67479359
45	MP0000432_abnormal_head_morphology	0.67275344
46	MP0005508_abnormal_skeleton_morphology	0.65512802
47	MP0002822_catalepsy	0.63060522
48	MP0003935_abnormal_craniofacial_develop	0.61338009
49	MP0009672_abnormal_birth_weight	0.60055478
50	MP0002184_abnormal_innervation	0.58697270
51	MP0000377_abnormal_hair_follicle	0.57649441
52	MP0001175_abnormal_lung_morphology	0.57442792
53	MP0002697_abnormal_eye_size	0.56167746
54	MP0009763_increased_sensitivity_to	0.53597927
55	MP0000681_abnormal_thyroid_gland	0.51907547
56	MP0005423_abnormal_somatic_nervous	0.49918319
57	MP0002113_abnormal_skeleton_development	0.49743973
58	MP0002102_abnormal_ear_morphology	0.48994894
59	MP0005253_abnormal_eye_physiology	0.48799121
60	MP0000604_amyloidosis	0.45743639
61	MP0000163_abnormal_cartilage_morphology	0.44492852
62	MP0002405_respiratory_system_inflammati	0.44385991
63	MP0002210_abnormal_sex_determination	0.43932298
64	MP0005391_vision/eye_phenotype	0.43916917
65	MP0000627_abnormal_mammary_gland	0.43653989
66	MP0002735_abnormal_chemical_nociception	0.42811685
67	MP0008058_abnormal_DNA_repair	0.42231604
68	MP0002234_abnormal_pharynx_morphology	0.42059241
69	MP0003638_abnormal_response/metabolism_	0.40783855
70	MP0003936_abnormal_reproductive_system	0.39741231
71	MP0002752_abnormal_somatic_nervous	0.35586276
72	MP0006276_abnormal_autonomic_nervous	0.29814981
73	MP0004197_abnormal_fetal_growth/weight/	0.29064895
74	MP0000049_abnormal_middle_ear	0.28937929
75	MP0010771_integument_phenotype	0.28453513
76	MP0002092_abnormal_eye_morphology	0.28216339
77	MP0005503_abnormal_tendon_morphology	0.27225425
78	MP0002116_abnormal_craniofacial_bone	0.27065199
79	MP0008004_abnormal_stomach_pH	0.26639038
80	MP0003448_altered_tumor_morphology	0.26620135
81	MP0000350_abnormal_cell_proliferation	0.26612979
82	MP0000955_abnormal_spinal_cord	0.25461561
83	MP0005377_hearing/vestibular/ear_phenot	0.25227875
84	MP0003878_abnormal_ear_physiology	0.25227875
85	MP0002081_perinatal_lethality	0.24977585
86	MP0002136_abnormal_kidney_physiology	0.24371749
87	MP0005257_abnormal_intraocular_pressure	0.23626031
88	MP0005084_abnormal_gallbladder_morpholo	0.22793061
89	MP0005390_skeleton_phenotype	0.21582703
90	MP0002168_other_aberrant_phenotype	0.19756927
91	MP0003091_abnormal_cell_migration	0.19414076
92	MP0005645_abnormal_hypothalamus_physiol	0.18088046
93	MP0005195_abnormal_posterior_eye	0.17518459
94	MP0000579_abnormal_nail_morphology	0.17166959
95	MP0000462_abnormal_digestive_system	0.16776139
96	MP0005025_abnormal_response_to	0.16243179
97	MP0000343_altered_response_to	0.16055454
98	MP0004484_altered_response_of	0.14386324
99	MP0005332_abnormal_amino_acid	0.14185207
100	MP0005171_absent_coat_pigmentation	0.13723609

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.05573076
2	Long foot (HP:0001833)	8.88019562
3	Abnormality of the renal collecting system (HP:0004742)	8.07159760
4	Adactyly (HP:0009776)	7.14184336
5	Large for gestational age (HP:0001520)	7.12350360
6	Acute lymphatic leukemia (HP:0006721)	6.98585480
7	Hypoplastic pelvis (HP:0008839)	6.89358075
8	Progressive muscle weakness (HP:0003323)	6.39204169
9	Abnormality of fatty-acid metabolism (HP:0004359)	6.02000004
10	Autoamputation (HP:0001218)	5.70863172
11	Dry hair (HP:0011359)	5.62031291
12	Pulmonary artery stenosis (HP:0004415)	5.47770930
13	Ureteral stenosis (HP:0000071)	5.32557941
14	Menstrual irregularities (HP:0000858)	5.31142527
15	Steatorrhea (HP:0002570)	5.20602327
16	Hypoplastic nipples (HP:0002557)	5.12875777
17	Ureteral obstruction (HP:0006000)	5.01269224
18	Ureteral duplication (HP:0000073)	4.98024413
19	Brushfield spots (HP:0001088)	4.84559542
20	Reduced subcutaneous adipose tissue (HP:0003758)	4.51561601
21	Severe muscular hypotonia (HP:0006829)	4.51164540
22	Abnormal auditory evoked potentials (HP:0006958)	4.49330838
23	Sudden death (HP:0001699)	4.40771357
24	Abnormal ventriculo-arterial connection (HP:0011563)	4.31446445
25	Transposition of the great arteries (HP:0001669)	4.31446445
26	Abnormal connection of the cardiac segments (HP:0011545)	4.31446445
27	Decreased lacrimation (HP:0000633)	4.12226133
28	Fat malabsorption (HP:0002630)	4.02496498
29	Increased number of teeth (HP:0011069)	3.96552783
30	Anhidrosis (HP:0000970)	3.87524854
31	Myoglobinuria (HP:0002913)	3.77442374
32	Broad-based gait (HP:0002136)	3.70928127
33	Palmoplantar hyperkeratosis (HP:0000972)	3.57169829
34	Abnormality of vision evoked potentials (HP:0000649)	3.43732679
35	Palmar hyperkeratosis (HP:0010765)	3.42620766
36	Broad nasal tip (HP:0000455)	3.20333409
37	Wide intermamillary distance (HP:0006610)	3.14932861
38	Polyneuropathy (HP:0001271)	3.11584880
39	Decreased muscle mass (HP:0003199)	3.11330381
40	Generalized amyotrophy (HP:0003700)	3.11195241
41	Large hands (HP:0001176)	3.05639743
42	Polymicrogyria (HP:0002126)	2.98914544
43	Rhabdomyolysis (HP:0003201)	2.92078984
44	Hypoplastic iliac wings (HP:0002866)	2.90415408
45	Plantar hyperkeratosis (HP:0007556)	2.89508004
46	Flat face (HP:0012368)	2.58855486
47	Clubbing of toes (HP:0100760)	2.56723392
48	Overfolded helix (HP:0000396)	2.48425943
49	Epiphyseal stippling (HP:0010655)	2.47356456
50	Chorioretinal coloboma (HP:0000567)	2.47035499
51	Steppage gait (HP:0003376)	2.45419349
52	Abnormally folded helix (HP:0008544)	2.39103780
53	Basal ganglia calcification (HP:0002135)	2.34021526
54	Thickened calvaria (HP:0002684)	2.30582427
55	Widely spaced teeth (HP:0000687)	2.29979623
56	Anxiety (HP:0000739)	2.21946390
57	Aplasia/Hypoplasia of the nipples (HP:0006709)	2.21784201
58	Absent toe (HP:0010760)	2.19474076
59	Generalized muscle weakness (HP:0003324)	2.18324812
60	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.17961014
61	Purpura (HP:0000979)	2.16400082
62	Posterior embryotoxon (HP:0000627)	2.02513808
63	Foot dorsiflexor weakness (HP:0009027)	2.01815078
64	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.9303914
65	Scrotal hypoplasia (HP:0000046)	1.99351090
66	Female pseudohermaphroditism (HP:0010458)	1.98110009
67	Prenatal maternal abnormality (HP:0002686)	1.95116216
68	Abnormality of the line of Schwalbe (HP:0008048)	1.95045817
69	Hammertoe (HP:0001765)	1.89428658
70	Abnormality of the epiphyses of the hand (HP:0005924)	1.87166254
71	External ear malformation (HP:0008572)	1.86409076
72	Thickened nuchal skin fold (HP:0000474)	1.86126281
73	Abnormality of the foot musculature (HP:0001436)	1.81844061
74	Stereotypic behavior (HP:0000733)	1.81760739
75	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.79570732
76	Congenital onset (HP:0003577)	1.78283393
77	Calf muscle hypertrophy (HP:0008981)	1.75942170
78	Primary adrenal insufficiency (HP:0008207)	1.74265976
79	Abnormal epiphyseal ossification (HP:0010656)	1.73592633
80	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.73220336
81	Short philtrum (HP:0000322)	1.73008531
82	Spastic tetraplegia (HP:0002510)	1.72484484
83	Hypoplastic ilia (HP:0000946)	1.70875890
84	Arthrogryposis multiplex congenita (HP:0002804)	1.69707910
85	Gangrene (HP:0100758)	1.67591600
86	Muscle hypertrophy of the lower extremities (HP:0008968)	1.65198034
87	Brachycephaly (HP:0000248)	1.58836036
88	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.58207816
89	Decreased motor nerve conduction velocity (HP:0003431)	1.57096112
90	Arterial thrombosis (HP:0004420)	1.56712070
91	Underdeveloped supraorbital ridges (HP:0009891)	1.53289326
92	Nail dystrophy (HP:0008404)	1.50883472
93	Depressed nasal ridge (HP:0000457)	1.42772407
94	Abnormality of primary teeth (HP:0006481)	1.40535565
95	Opacification of the corneal stroma (HP:0007759)	1.39651363
96	Abnormality of the wing of the ilium (HP:0011867)	1.36510122
97	Lactic acidosis (HP:0003128)	1.33158440
98	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.32444148
99	Hydronephrosis (HP:0000126)	1.28416742
100	Venous insufficiency (HP:0005293)	1.26417789

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.95140481
2	TAOK1	5.46268623
3	TAOK2	5.46148792
4	MAP3K3	3.98495059
5	MAP3K11	3.97471585
6	MAP2K3	3.85570236
7	JAK3	2.33337105
8	MKNK2	11.6201351
9	ABL2	1.85292691
10	DYRK1A	1.76170350
11	MAP3K5	1.33002494
12	MAP3K1	1.06278428
13	MAPK15	0.97632758
14	SRPK1	0.95941995
15	CHEK2	0.78605272
16	MAP3K8	0.64011629
17	PRKCQ	0.44407155
18	MAP4K2	0.40921063
19	TIE1	0.30157086
20	CSNK1A1	0.20519939
21	ABL1	0.17133515
22	TXK	0.16136166
23	INSRR	0.14383987
24	IGF1R	0.13546381
25	PNCK	0.12308407
26	OBSCN	0.11309520
27	GRK1	0.10239884
28	ADRBK2	0.09480883
29	VRK1	0.09439702
30	LMTK2	0.08186008
31	MUSK	0.07151814
32	WNK3	0.06920184
33	PHKG2	0.06188170
34	PHKG1	0.06188170
35	EPHA2	0.05742381
36	CSNK2A2	0.05547682
37	TSSK6	0.05202139
38	PRKCD	0.04560446
39	GRK7	0.04294834
40	CSNK1E	0.02791480
41	AURKA	0.02412653
42	CSNK2A1	0.01521649
43	ERBB4	0.01380712
44	CDK3	0.00334399
45	MOS	-0.1208281
46	CAMK2G	-0.1193440
47	IRAK3	-0.1192398
48	KIT	-0.1186178
49	BTK	-0.1173446
50	MAP2K7	-0.1151708
51	NEK6	-0.1143908
52	EPHA3	-0.1141718
53	GSK3A	-0.1140566
54	WNK4	-0.1127277
55	MAP3K2	-0.1099068
56	IKBKE	-0.1069500
57	PRKG2	-0.1057926
58	CAMK2A	-0.1025829
59	MAP3K4	-0.1016228
60	NTRK2	-0.0996242
61	TTN	-0.0991838
62	ITK	-0.0990487
63	ZAK	-0.0973323
64	MAPK14	-0.0953097
65	PIM2	-0.0934222
66	PLK2	-0.0933942
67	KDR	-0.0915891
68	CDK2	-0.0913142
69	MYLK	-0.0895067
70	GRK5	-0.0869805
71	MAPK13	-0.0869679
72	PRKG1	-0.0857322
73	MATK	-0.0775584
74	MAPKAPK5	-0.0763486
75	EPHA4	-0.0752706
76	ADRBK1	-0.0744885
77	PRKCE	-0.0717980
78	NTRK3	-0.0714761
79	GRK6	-0.0637570
80	PAK2	-0.0619134
81	PRKCG	-0.0612837
82	MARK1	-0.0603422
83	FER	-0.0596336
84	PKN1	-0.0590915
85	TLK1	-0.0438038
86	PRKACA	-0.0434715
87	CASK	-0.0411468
88	OXSR1	-0.0386591
89	SRC	-0.0378155
90	TEC	-0.0345227
91	MST1R	-0.0316956
92	STK39	-0.0300377
93	CDK8	-0.0283668
94	PIK3CG	-0.0233394
95	TNK2	-0.0176177
96	PRKCB	-0.0165655
97	PLK4	-0.0158698
98	WEE1	-0.0085575
99	PRKCA	-0.0082703
100	DDR2	-0.0012898

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.68134603
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.17649296
3	Taste transduction_Homo sapiens_hsa04742	3.21503765
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.18843629
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	3.07169454
6	RNA polymerase_Homo sapiens_hsa03020	3.03984574
7	Fatty acid elongation_Homo sapiens_hsa00062	2.87576741
8	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.83892267
9	Lysine degradation_Homo sapiens_hsa00310	2.62916131
10	Butanoate metabolism_Homo sapiens_hsa00650	2.49681035
11	beta-Alanine metabolism_Homo sapiens_hsa00410	1.85877823
12	Amoebiasis_Homo sapiens_hsa05146	1.83824511
13	Glycerolipid metabolism_Homo sapiens_hsa00561	1.68086909
14	One carbon pool by folate_Homo sapiens_hsa00670	1.67826070
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.67629616
16	Propanoate metabolism_Homo sapiens_hsa00640	1.62300524
17	Proteasome_Homo sapiens_hsa03050	1.24736379
18	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.18128264
19	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.09424395
20	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.05417722
21	Viral myocarditis_Homo sapiens_hsa05416	1.01591311
22	Fatty acid degradation_Homo sapiens_hsa00071	0.97565488
23	Fatty acid metabolism_Homo sapiens_hsa01212	0.93708056
24	Complement and coagulation cascades_Homo sapiens_hsa04610	0.84477482
25	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79163140
26	Peroxisome_Homo sapiens_hsa04146	0.75163423
27	AMPK signaling pathway_Homo sapiens_hsa04152	0.74245588
28	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.74002376
29	Salmonella infection_Homo sapiens_hsa05132	0.72850608
30	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.72575245
31	GnRH signaling pathway_Homo sapiens_hsa04912	0.71477211
32	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.70736493
33	MicroRNAs in cancer_Homo sapiens_hsa05206	0.68171546
34	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.66348489
35	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.63073381
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.62910196
37	Caffeine metabolism_Homo sapiens_hsa00232	0.62882879
38	Cholinergic synapse_Homo sapiens_hsa04725	0.61704852
39	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.61508188
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55667462
41	Nicotine addiction_Homo sapiens_hsa05033	0.54269287
42	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.53775017
43	Olfactory transduction_Homo sapiens_hsa04740	0.51523645
44	Choline metabolism in cancer_Homo sapiens_hsa05231	0.51233496
45	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47476537
46	TNF signaling pathway_Homo sapiens_hsa04668	0.46080197
47	Phototransduction_Homo sapiens_hsa04744	0.42400402
48	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.42120428
49	Retinol metabolism_Homo sapiens_hsa00830	0.41400840
50	Linoleic acid metabolism_Homo sapiens_hsa00591	0.41107059
51	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.39783741
52	Toxoplasmosis_Homo sapiens_hsa05145	0.37510615
53	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.36599028
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.35858579
55	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.32466665
56	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.31985708
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.31074447
58	Protein digestion and absorption_Homo sapiens_hsa04974	0.29506723
59	ECM-receptor interaction_Homo sapiens_hsa04512	0.28160349
60	Nucleotide excision repair_Homo sapiens_hsa03420	0.27748215
61	Basal cell carcinoma_Homo sapiens_hsa05217	0.27716980
62	MAPK signaling pathway_Homo sapiens_hsa04010	0.26572159
63	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.26553111
64	Cocaine addiction_Homo sapiens_hsa05030	0.26209148
65	Phenylalanine metabolism_Homo sapiens_hsa00360	0.24897508
66	Salivary secretion_Homo sapiens_hsa04970	0.23837971
67	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.22830850
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.21811040
69	Malaria_Homo sapiens_hsa05144	0.20558207
70	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.20426763
71	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.20264707
72	Rap1 signaling pathway_Homo sapiens_hsa04015	0.19992577
73	Insulin secretion_Homo sapiens_hsa04911	0.19840353
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.18235360
75	Chemical carcinogenesis_Homo sapiens_hsa05204	0.17619352
76	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.17289706
77	RNA transport_Homo sapiens_hsa03013	0.17055665
78	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.16995468
79	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.16454593
80	Phagosome_Homo sapiens_hsa04145	0.15866812
81	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.15391668
82	Fat digestion and absorption_Homo sapiens_hsa04975	0.14522590
83	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.14441341
84	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.13647538
85	Purine metabolism_Homo sapiens_hsa00230	0.12616048
86	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.12614973
87	Type I diabetes mellitus_Homo sapiens_hsa04940	0.12353802
88	Asthma_Homo sapiens_hsa05310	0.11929929
89	Mineral absorption_Homo sapiens_hsa04978	0.11740455
90	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.11090191
91	Bile secretion_Homo sapiens_hsa04976	0.10575059
92	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.10369327
93	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.10204460
94	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.10149264
95	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.10085973
96	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.09770992
97	Serotonergic synapse_Homo sapiens_hsa04726	0.09727161
98	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	0.09418830
99	Amphetamine addiction_Homo sapiens_hsa05031	0.08991144
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.08747884

TMED10P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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