ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	9.55361170
2	eosinophil migration (GO:0072677)	9.51177891
3	regulation of sister chromatid cohesion (GO:0007063)	9.49875021
4	regulation of mononuclear cell migration (GO:0071675)	9.35668825
5	branch elongation of an epithelium (GO:0060602)	8.57836813
6	negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)	8.16430460
7	negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)	7.87235925
8	positive regulation of chromosome segregation (GO:0051984)	7.86474465
9	fucose catabolic process (GO:0019317)	7.78282957
10	L-fucose metabolic process (GO:0042354)	7.78282957
11	L-fucose catabolic process (GO:0042355)	7.78282957
12	vesicle fusion (GO:0006906)	7.66632225
13	peptidyl-lysine dimethylation (GO:0018027)	7.64461198
14	coenzyme A biosynthetic process (GO:0015937)	7.22052869
15	ribosomal small subunit assembly (GO:0000028)	7.11930430
16	autophagic vacuole fusion (GO:0000046)	7.01455863
17	localization within membrane (GO:0051668)	6.71098606
18	macrophage chemotaxis (GO:0048246)	6.51856828
19	organ growth (GO:0035265)	6.50611872
20	axis elongation (GO:0003401)	6.47148191
21	regulation of beta-amyloid formation (GO:1902003)	5.94555114
22	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	5.92854889
23	establishment of mitotic spindle orientation (GO:0000132)	5.86717645
24	negative regulation of GTPase activity (GO:0034260)	5.85460699
25	negative regulation of GTP catabolic process (GO:0033125)	5.85460699
26	positive regulation of calcium ion import (GO:0090280)	5.81616408
27	regulation of T cell receptor signaling pathway (GO:0050856)	5.56863389
28	organelle membrane fusion (GO:0090174)	5.54436016
29	monocyte chemotaxis (GO:0002548)	5.44248447
30	protein import into peroxisome matrix (GO:0016558)	5.41172961
31	acrosome assembly (GO:0001675)	5.15826938
32	establishment of mitotic spindle localization (GO:0040001)	5.14760707
33	histone H3-K9 methylation (GO:0051567)	5.14638144
34	establishment of spindle orientation (GO:0051294)	5.11923601
35	double-strand break repair via nonhomologous end joining (GO:0006303)	5.04109360
36	non-recombinational repair (GO:0000726)	5.04109360
37	3-UTR-mediated mRNA stabilization (GO:0070935)	4.98427896
38	seminiferous tubule development (GO:0072520)	4.89689706
39	regulation of amyloid precursor protein catabolic process (GO:1902991)	4.78296808
40	negative regulation of circadian rhythm (GO:0042754)	4.76767559
41	positive chemotaxis (GO:0050918)	4.72250309
42	oxidative demethylation (GO:0070989)	4.67247691
43	detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)	4.67206427
44	organelle fusion (GO:0048284)	4.65473686
45	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	4.63832543
46	regulation of stem cell maintenance (GO:2000036)	4.60336100
47	pantothenate metabolic process (GO:0015939)	4.55380397
48	purine nucleoside bisphosphate biosynthetic process (GO:0034033)	4.54423764
49	ribonucleoside bisphosphate biosynthetic process (GO:0034030)	4.54423764
50	nucleoside bisphosphate biosynthetic process (GO:0033866)	4.54423764
51	fucose metabolic process (GO:0006004)	4.46401328
52	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	4.41709866
53	protein targeting to vacuole (GO:0006623)	4.38605840
54	protein targeting to lysosome (GO:0006622)	4.38605840
55	establishment of protein localization to vacuole (GO:0072666)	4.38605840
56	histone H3-K9 modification (GO:0061647)	4.27961137
57	regulation of autophagic vacuole assembly (GO:2000785)	4.22576133
58	regulation of fibroblast growth factor receptor signaling pathway (GO:0040036)	4.22246126
59	coenzyme A metabolic process (GO:0015936)	4.17054493
60	fucosylation (GO:0036065)	4.15322789
61	membrane budding (GO:0006900)	4.12603077
62	negative regulation of purine nucleotide catabolic process (GO:0033122)	4.06871964
63	single-organism membrane fusion (GO:0044801)	4.03602221
64	detection of chemical stimulus involved in sensory perception of taste (GO:0050912)	3.99153058
65	regulation of antigen receptor-mediated signaling pathway (GO:0050854)	3.91210866
66	negative regulation of nucleotide catabolic process (GO:0030812)	3.89608187
67	regulation of mammary gland epithelial cell proliferation (GO:0033599)	3.80133561
68	regulation of cellular amide metabolic process (GO:0034248)	3.79992028
69	regulation of peptidyl-threonine phosphorylation (GO:0010799)	3.78313749
70	negative regulation of nucleoside metabolic process (GO:0045978)	3.77404389
71	establishment of spindle localization (GO:0051293)	3.73060774
72	vesicle targeting (GO:0006903)	3.69367786
73	ER to Golgi vesicle-mediated transport (GO:0006888)	3.61670425
74	regulation of vacuole organization (GO:0044088)	3.53918811
75	regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:2	3.53513718
76	imidazole-containing compound metabolic process (GO:0052803)	3.53388644
77	regulation of calcium ion import (GO:0090279)	3.53070795
78	protein localization to peroxisome (GO:0072662)	3.50643257
79	protein targeting to peroxisome (GO:0006625)	3.50643257
80	establishment of protein localization to peroxisome (GO:0072663)	3.50643257
81	sodium-independent organic anion transport (GO:0043252)	3.46341724
82	negative regulation of dendrite morphogenesis (GO:0050774)	3.44260347
83	DNA integration (GO:0015074)	3.43021591
84	COPI coating of Golgi vesicle (GO:0048205)	3.38349816
85	Golgi transport vesicle coating (GO:0048200)	3.38349816
86	peptidyl-lysine trimethylation (GO:0018023)	3.31818150
87	cellular senescence (GO:0090398)	3.27543754
88	preassembly of GPI anchor in ER membrane (GO:0016254)	3.26794839
89	COPII vesicle coating (GO:0048208)	3.26726477
90	labyrinthine layer development (GO:0060711)	3.26331177
91	negative regulation of macroautophagy (GO:0016242)	3.26261215
92	peroxisomal transport (GO:0043574)	3.26087150
93	protein prenylation (GO:0018342)	12.6792824
94	prenylation (GO:0097354)	12.6792824
95	positive regulation of mitotic sister chromatid separation (GO:1901970)	12.1612368
96	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	12.1612368
97	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	12.1612368
98	negative regulation of Ras GTPase activity (GO:0034261)	12.1529586
99	eosinophil chemotaxis (GO:0048245)	10.5200213
100	negative regulation of T cell receptor signaling pathway (GO:0050860)	10.1844971

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	8.65098072
2	VDR_22108803_ChIP-Seq_LS180_Human	6.20213776
3	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.69090637
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	4.32320817
5	AR_21572438_ChIP-Seq_LNCaP_Human	3.51300080
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.01140271
7	SRY_22984422_ChIP-ChIP_TESTIS_Rat	2.65749541
8	ZIC3_20872845_ChIP-ChIP_MESCs_Mouse	2.52036591
9	ZNF263_19887448_ChIP-Seq_K562_Human	2.46376465
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.37642341
11	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	2.26391557
12	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	2.11058042
13	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.08919971
14	GATA1_22025678_ChIP-Seq_K562_Human	11.8008510
15	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.91375798
16	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.91375798
17	RXR_22108803_ChIP-Seq_LS180_Human	1.86389782
18	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.64814662
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.63590814
20	BCAT_22108803_ChIP-Seq_LS180_Human	1.63536564
21	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.60106963
22	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.60106963
23	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.60106963
24	GBX2_23144817_ChIP-Seq_PC3_Human	1.57624772
25	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.57164367
26	TP53_16413492_ChIP-PET_HCT116_Human	1.45419302
27	TAF15_26573619_Chip-Seq_HEK293_Human	1.43447741
28	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.43349998
29	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.41286753
30	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.37948234
31	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.31286598
32	GATA3_26560356_Chip-Seq_TH1_Human	1.30180196
33	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.25792621
34	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.16648069
35	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.15846373
36	STAT3_1855785_ChIP-Seq_MESCs_Mouse	1.15255236
37	IRF1_19129219_ChIP-ChIP_H3396_Human	1.11360792
38	GATA1_19941826_ChIP-Seq_K562_Human	1.08622456
39	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.07152108
40	RUNX_20019798_ChIP-Seq_JUKART_Human	1.04781881
41	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.03043235
42	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.02050355
43	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.01659609
44	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.97868809
45	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	0.96343982
46	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.95063325
47	ASXL1_24218140_ChIP-Seq_BMDM_Mouse	0.93820956
48	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93410114
49	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.92669065
50	TBX3_20139965_ChIP-Seq_ESCs_Mouse	0.90266336
51	TBX3_20139965_ChIP-Seq_MESCs_Mouse	0.89942554
52	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.89610633
53	CTCF_21964334_Chip-Seq_Bcells_Human	0.89592256
54	EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse	0.89236374
55	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	0.87720770
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.85014522
57	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	0.83807987
58	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	0.80500288
59	EZH2_22144423_ChIP-Seq_EOC_Human	0.79763504
60	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.79345582
61	SOX3_22085726_ChIP-Seq_MUSCLE_Mouse	0.77467875
62	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.76380494
63	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	0.74316885
64	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.73510285
65	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.71110380
66	RING1B_27294783_Chip-Seq_NPCs_Mouse	0.67820244
67	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.67378540
68	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.66447448
69	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.66174498
70	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.66174498
71	NR3C1_23031785_ChIP-Seq_PC12_Mouse	0.65515116
72	TRIM28_19339689_ChIP-ChIP_MESCs_Mouse	0.65047350
73	GATA2_19941826_ChIP-Seq_K562_Human	0.64873859
74	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.64824512
75	ZNF274_21170338_ChIP-Seq_K562_Hela	0.64655168
76	IKZF1_21737484_ChIP-ChIP_HCT116_Human	0.64307682
77	TP53_22573176_ChIP-Seq_HFKS_Human	0.63940690
78	SMC1_22415368_ChIP-Seq_MEFs_Mouse	0.63798263
79	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.62094896
80	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.61211905
81	FUS_26573619_Chip-Seq_HEK293_Human	0.60398895
82	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.59634721
83	P300_19829295_ChIP-Seq_ESCs_Human	0.59538226
84	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.58927836
85	EOMES_20176728_ChIP-ChIP_TSCs_Mouse	0.57984419
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.57191511
87	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.56707123
88	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.56348919
89	PIAS1_25552417_ChIP-Seq_VCAP_Human	0.54637919
90	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.54565243
91	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	0.54492231
92	PU1_27457419_Chip-Seq_LIVER_Mouse	0.54255725
93	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.53562249
94	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.53553365
95	SMC3_22415368_ChIP-Seq_MEFs_Mouse	0.53273433
96	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.52734007
97	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.51485624
98	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.51198891
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.51164717
100	HTT_18923047_ChIP-ChIP_STHdh_Human	0.50876032

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003303_peritoneal_inflammation	9.98784569
2	MP0006082_CNS_inflammation	5.30547393
3	MP0001664_abnormal_digestion	3.38537532
4	MP0000467_abnormal_esophagus_morphology	3.34282778
5	MP0001663_abnormal_digestive_system	3.22438590
6	MP0003115_abnormal_respiratory_system	2.63140852
7	MP0001919_abnormal_reproductive_system	2.60708839
8	MP0000383_abnormal_hair_follicle	2.52234964
9	MP0005381_digestive/alimentary_phenotyp	2.49885667
10	MP0002751_abnormal_autonomic_nervous	2.43596153
11	MP0000566_synostosis	12.9228272
12	MP0001915_intracranial_hemorrhage	1.81153681
13	MP0001545_abnormal_hematopoietic_system	1.75204160
14	MP0005397_hematopoietic_system_phenotyp	1.75204160
15	MP0000534_abnormal_ureter_morphology	1.74679317
16	MP0002876_abnormal_thyroid_physiology	1.73111037
17	MP0005166_decreased_susceptibility_to	1.71829975
18	MP0010678_abnormal_skin_adnexa	1.66638090
19	MP0005389_reproductive_system_phenotype	1.63924031
20	MP0003937_abnormal_limbs/digits/tail_de	1.59041564
21	MP0003453_abnormal_keratinocyte_physiol	1.50978648
22	MP0000428_abnormal_craniofacial_morphol	1.48938862
23	MP0005076_abnormal_cell_differentiation	1.42458778
24	MP0000858_altered_metastatic_potential	1.15739781
25	MP0005501_abnormal_skin_physiology	1.14547522
26	MP0001286_abnormal_eye_development	1.05281449
27	MP0001293_anophthalmia	1.02838973
28	MP0000490_abnormal_crypts_of	0.99097420
29	MP0003763_abnormal_thymus_physiology	0.97730783
30	MP0003942_abnormal_urinary_system	0.97054095
31	MP0002109_abnormal_limb_morphology	0.91023705
32	MP0008004_abnormal_stomach_pH	0.90496722
33	MP0002115_abnormal_skeleton_extremities	0.90097302
34	MP0003329_amyloid_beta_deposits	0.89380890
35	MP0002019_abnormal_tumor_incidence	0.88777792
36	MP0000470_abnormal_stomach_morphology	0.88411728
37	MP0005508_abnormal_skeleton_morphology	0.82716640
38	MP0005023_abnormal_wound_healing	0.76566026
39	MP0001764_abnormal_homeostasis	0.75393297
40	MP0010155_abnormal_intestine_physiology	0.74633535
41	MP0009763_increased_sensitivity_to	0.72998133
42	MP0005197_abnormal_uvea_morphology	0.70409922
43	MP0000026_abnormal_inner_ear	0.68435677
44	MP0001963_abnormal_hearing_physiology	0.67289024
45	MP0000358_abnormal_cell_content/	0.66600488
46	MP0000432_abnormal_head_morphology	0.64769918
47	MP0000477_abnormal_intestine_morphology	0.63574905
48	MP0005503_abnormal_tendon_morphology	0.63236229
49	MP0005275_abnormal_skin_tensile	0.61931213
50	MP0002405_respiratory_system_inflammati	0.61309534
51	MP0003011_delayed_dark_adaptation	0.60927691
52	MP0001175_abnormal_lung_morphology	0.60062315
53	MP0000604_amyloidosis	0.56640862
54	MP0003935_abnormal_craniofacial_develop	0.55941221
55	MP0002113_abnormal_skeleton_development	0.55240485
56	MP0000681_abnormal_thyroid_gland	0.54694951
57	MP0009672_abnormal_birth_weight	0.54138523
58	MP0002184_abnormal_innervation	0.48861659
59	MP0002210_abnormal_sex_determination	0.48691356
60	MP0003283_abnormal_digestive_organ	0.47355532
61	MP0003638_abnormal_response/metabolism_	0.44954491
62	MP0000163_abnormal_cartilage_morphology	0.44474422
63	MP0003448_altered_tumor_morphology	0.44108464
64	MP0002168_other_aberrant_phenotype	0.43599030
65	MP0005253_abnormal_eye_physiology	0.41596492
66	MP0000377_abnormal_hair_follicle	0.40908547
67	MP0003936_abnormal_reproductive_system	0.39424281
68	MP0008438_abnormal_cutaneous_collagen	0.39093641
69	MP0000627_abnormal_mammary_gland	0.37267785
70	MP0005390_skeleton_phenotype	0.34767061
71	MP0002136_abnormal_kidney_physiology	0.33160111
72	MP0005391_vision/eye_phenotype	0.31706705
73	MP0010771_integument_phenotype	0.31444606
74	MP0002736_abnormal_nociception_after	0.31371253
75	MP0000343_altered_response_to	0.29671796
76	MP0005025_abnormal_response_to	0.29387179
77	MP0000350_abnormal_cell_proliferation	0.27556630
78	MP0003091_abnormal_cell_migration	0.26416201
79	MP0003195_calcinosis	0.26054671
80	MP0002697_abnormal_eye_size	0.24756082
81	MP0009931_abnormal_skin_appearance	0.24106506
82	MP0000049_abnormal_middle_ear	0.23878120
83	MP0001986_abnormal_taste_sensitivity	0.22945620
84	MP0008058_abnormal_DNA_repair	0.21659531
85	MP0004197_abnormal_fetal_growth/weight/	0.21342910
86	MP0003315_abnormal_perineum_morphology	0.20504479
87	MP0002752_abnormal_somatic_nervous	0.20177288
88	MP0002116_abnormal_craniofacial_bone	0.18276114
89	MP0002822_catalepsy	0.17621451
90	MP0005332_abnormal_amino_acid	0.17332161
91	MP0004484_altered_response_of	0.17201185
92	MP0002735_abnormal_chemical_nociception	0.16901905
93	MP0002081_perinatal_lethality	0.15850028
94	MP0001968_abnormal_touch/_nociception	0.15783834
95	MP0002161_abnormal_fertility/fecundity	0.14685973
96	MP0003279_aneurysm	0.14427644
97	MP0001119_abnormal_female_reproductive	0.14319179
98	MP0002092_abnormal_eye_morphology	0.14187627
99	MP0001958_emphysema	0.14090164
100	MP0010386_abnormal_urinary_bladder	0.13735276

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Duplicated collecting system (HP:0000081)	9.22846452
2	Long foot (HP:0001833)	9.09835095
3	Abnormality of the renal collecting system (HP:0004742)	8.21859414
4	Acute lymphatic leukemia (HP:0006721)	7.27064702
5	Large for gestational age (HP:0001520)	7.17113273
6	Adactyly (HP:0009776)	6.58635312
7	Progressive muscle weakness (HP:0003323)	6.53822015
8	Abnormality of fatty-acid metabolism (HP:0004359)	6.10373977
9	Hypoplastic pelvis (HP:0008839)	6.00797557
10	Autoamputation (HP:0001218)	5.77417406
11	Pulmonary artery stenosis (HP:0004415)	5.72065538
12	Dry hair (HP:0011359)	5.55539112
13	Ureteral stenosis (HP:0000071)	5.40876818
14	Menstrual irregularities (HP:0000858)	5.21096815
15	Steatorrhea (HP:0002570)	5.08671784
16	Ureteral obstruction (HP:0006000)	5.06761834
17	Ureteral duplication (HP:0000073)	5.05783577
18	Brushfield spots (HP:0001088)	4.90572662
19	Hypoplastic nipples (HP:0002557)	4.89965847
20	Abnormal auditory evoked potentials (HP:0006958)	4.68220559
21	Sudden death (HP:0001699)	4.43186108
22	Increased number of teeth (HP:0011069)	4.40346123
23	Reduced subcutaneous adipose tissue (HP:0003758)	4.37786703
24	Abnormal ventriculo-arterial connection (HP:0011563)	4.32146159
25	Transposition of the great arteries (HP:0001669)	4.32146159
26	Abnormal connection of the cardiac segments (HP:0011545)	4.32146159
27	Severe muscular hypotonia (HP:0006829)	3.96441225
28	Fat malabsorption (HP:0002630)	3.92901074
29	Decreased lacrimation (HP:0000633)	3.88638439
30	Anhidrosis (HP:0000970)	3.83344111
31	Palmoplantar hyperkeratosis (HP:0000972)	3.62819213
32	Broad-based gait (HP:0002136)	3.59717762
33	Abnormality of vision evoked potentials (HP:0000649)	3.52101865
34	Palmar hyperkeratosis (HP:0010765)	3.40883315
35	Generalized amyotrophy (HP:0003700)	3.31349202
36	Decreased muscle mass (HP:0003199)	3.24634131
37	Broad nasal tip (HP:0000455)	3.24375251
38	Wide intermamillary distance (HP:0006610)	3.20585434
39	Polyneuropathy (HP:0001271)	3.17218833
40	Large hands (HP:0001176)	3.12659187
41	Myoglobinuria (HP:0002913)	3.03378268
42	Polymicrogyria (HP:0002126)	2.98514203
43	Plantar hyperkeratosis (HP:0007556)	2.89621872
44	Rhabdomyolysis (HP:0003201)	2.81077070
45	Flat face (HP:0012368)	2.70259871
46	Steppage gait (HP:0003376)	2.65312717
47	Purpura (HP:0000979)	2.61252368
48	Hypoplastic iliac wings (HP:0002866)	2.60405098
49	Clubbing of toes (HP:0100760)	2.59751242
50	Epiphyseal stippling (HP:0010655)	2.53731982
51	Chorioretinal coloboma (HP:0000567)	2.52610798
52	Thickened calvaria (HP:0002684)	2.48934449
53	Foot dorsiflexor weakness (HP:0009027)	2.42345342
54	Widely spaced teeth (HP:0000687)	2.39346399
55	Overfolded helix (HP:0000396)	2.32472581
56	Basal ganglia calcification (HP:0002135)	2.30829388
57	Hammertoe (HP:0001765)	2.26623570
58	Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)	2.22142472
59	Abnormality of the foot musculature (HP:0001436)	2.21660890
60	Posterior embryotoxon (HP:0000627)	2.17575177
61	Absent toe (HP:0010760)	2.17294715
62	Abnormally folded helix (HP:0008544)	2.11246227
63	Abnormality of the line of Schwalbe (HP:0008048)	2.09221905
64	Anxiety (HP:0000739)	2.00897097
65	Prenatal maternal abnormality (HP:0002686)	2.00345110
66	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	11.9066907
67	Aplasia/Hypoplasia of the nipples (HP:0006709)	1.99463421
68	Female pseudohermaphroditism (HP:0010458)	1.97933062
69	Abnormality of the epiphyses of the hand (HP:0005924)	1.94957091
70	Thickened nuchal skin fold (HP:0000474)	1.92580811
71	Generalized muscle weakness (HP:0003324)	1.89069341
72	Decreased motor nerve conduction velocity (HP:0003431)	1.87324724
73	External ear malformation (HP:0008572)	1.84315747
74	Spastic tetraplegia (HP:0002510)	1.84005563
75	Stereotypic behavior (HP:0000733)	1.82254358
76	Abnormality involving the epiphyses of the upper limbs (HP:0003839)	1.81966509
77	Short philtrum (HP:0000322)	1.81536849
78	Abnormal epiphyseal ossification (HP:0010656)	1.75497355
79	Congenital onset (HP:0003577)	1.74906683
80	Arterial thrombosis (HP:0004420)	1.74436705
81	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.74304485
82	Primary adrenal insufficiency (HP:0008207)	1.72162370
83	Brachycephaly (HP:0000248)	1.69882444
84	Arthrogryposis multiplex congenita (HP:0002804)	1.69630796
85	Gangrene (HP:0100758)	1.68346290
86	Aplasia/Hypoplasia involving the pelvis (HP:0009103)	1.62194046
87	Hypoplastic ilia (HP:0000946)	1.54168570
88	Scrotal hypoplasia (HP:0000046)	1.51061755
89	Underdeveloped supraorbital ridges (HP:0009891)	1.49385464
90	Venous insufficiency (HP:0005293)	1.49160710
91	Nail dystrophy (HP:0008404)	1.46593653
92	Depressed nasal ridge (HP:0000457)	1.44893747
93	Abnormality of primary teeth (HP:0006481)	1.39569003
94	Respiratory insufficiency due to muscle weakness (HP:0002747)	1.37859222
95	Abnormality of the wing of the ilium (HP:0011867)	1.35938508
96	Webbed neck (HP:0000465)	1.35757410
97	Pulmonary embolism (HP:0002204)	1.35271063
98	Opacification of the corneal stroma (HP:0007759)	1.28888655
99	Freckling (HP:0001480)	1.28788600
100	Postnatal microcephaly (HP:0005484)	1.28752619

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MKNK1	6.72780198
2	TAOK2	5.59007442
3	TAOK1	5.49435220
4	MAP2K3	4.29118354
5	MAP3K3	4.18982926
6	MAP3K11	4.11329260
7	JAK3	2.46619605
8	MKNK2	11.4395323
9	ABL2	1.88384146
10	DYRK1A	1.76006460
11	MAP3K5	1.40559120
12	MAP3K1	1.08684012
13	SRPK1	0.90933468
14	CHEK2	0.80039685
15	MAP3K8	0.68726924
16	PRKCQ	0.48150761
17	PIK3CG	0.22120658
18	ABL1	0.15997286
19	INSRR	0.15910997
20	CSNK1A1	0.15685426
21	IGF1R	0.15014367
22	DDR2	0.13940215
23	TIE1	0.13460581
24	OBSCN	0.11079756
25	PRKCD	0.07542439
26	ADRBK2	0.06247488
27	MYLK	0.05415837
28	GRK7	0.04786971
29	MUSK	0.04639806
30	GRK1	0.04414159
31	MAP2K6	0.03747224
32	TTN	0.03713211
33	PLK4	0.03290083
34	MAP4K2	0.02791836
35	CSNK2A2	0.02352011
36	CSNK2A1	0.00546022
37	ERBB4	0.00410681
38	PRKCA	0.00045657
39	CSK	-0.1249719
40	PLK2	-0.1213796
41	PRKCE	-0.1173320
42	FES	-0.1171150
43	IKBKE	-0.1167685
44	PRKCG	-0.1167443
45	ITK	-0.1151898
46	CDK3	-0.1141251
47	PINK1	-0.1138107
48	NTRK2	-0.1137338
49	PRKACG	-0.1123779
50	LYN	-0.1090958
51	MAPK4	-0.1078368
52	TRIM28	-0.1060413
53	PIK3CA	-0.1058425
54	EPHA2	-0.1054953
55	FRK	-0.1046655
56	MAPK14	-0.1030244
57	PRKG1	-0.1023954
58	CAMK2A	-0.1020223
59	CAMK2G	-0.1020190
60	CDK2	-0.1019099
61	MAPK12	-0.1004122
62	BMX	-0.0986081
63	PIM1	-0.0974814
64	BTK	-0.0962062
65	PASK	-0.0927737
66	WNK4	-0.0904495
67	NTRK1	-0.0889023
68	PKN1	-0.0813346
69	SYK	-0.0809147
70	PIM2	-0.0784651
71	PHKG2	-0.0760773
72	PHKG1	-0.0760773
73	KIT	-0.0684374
74	TAOK3	-0.0682577
75	GRK6	-0.0638013
76	PTK2B	-0.0629570
77	KDR	-0.0576145
78	NTRK3	-0.0552391
79	MAP2K4	-0.0548122
80	LMTK2	-0.0532552
81	CCNB1	-0.0477270
82	BLK	-0.0427961
83	MST1R	-0.0419926
84	TGFBR2	-0.0399389
85	WEE1	-0.0388257
86	GRK5	-0.0376058
87	TEC	-0.0374830
88	AKT3	-0.0357115
89	SIK2	-0.0333774
90	PRKACA	-0.0310144
91	ADRBK1	-0.0274725
92	TXK	-0.0210039
93	AURKA	-0.0209311
94	FLT3	-0.0191362
95	PRKCB	-0.0155711
96	SRC	-0.0137260
97	WNK3	-0.0106549
98	MAPK15	-0.0075169
99	CSNK1E	-0.0048643
100	MATK	-0.0018932

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	8.77778210
2	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	7.26062153
3	Taste transduction_Homo sapiens_hsa04742	3.19718622
4	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	3.15833102
5	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.92751421
6	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	2.71259988
7	RNA polymerase_Homo sapiens_hsa03020	2.68854152
8	Fatty acid elongation_Homo sapiens_hsa00062	2.64054317
9	Lysine degradation_Homo sapiens_hsa00310	2.58339478
10	Butanoate metabolism_Homo sapiens_hsa00650	2.39676992
11	Amoebiasis_Homo sapiens_hsa05146	2.06062687
12	Glycerolipid metabolism_Homo sapiens_hsa00561	1.79022642
13	beta-Alanine metabolism_Homo sapiens_hsa00410	1.76201143
14	Tryptophan metabolism_Homo sapiens_hsa00380	1.65836725
15	One carbon pool by folate_Homo sapiens_hsa00670	1.64477449
16	Propanoate metabolism_Homo sapiens_hsa00640	1.41138060
17	Proteasome_Homo sapiens_hsa03050	1.27319793
18	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.18172859
19	Fatty acid degradation_Homo sapiens_hsa00071	1.16756793
20	Fatty acid metabolism_Homo sapiens_hsa01212	1.08575220
21	Viral myocarditis_Homo sapiens_hsa05416	1.08164212
22	Complement and coagulation cascades_Homo sapiens_hsa04610	1.04861278
23	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	1.01065491
24	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.87154122
25	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.76533591
26	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.74933663
27	AMPK signaling pathway_Homo sapiens_hsa04152	0.71988012
28	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.70908438
29	MicroRNAs in cancer_Homo sapiens_hsa05206	0.67159723
30	Peroxisome_Homo sapiens_hsa04146	0.66306354
31	Olfactory transduction_Homo sapiens_hsa04740	0.64536580
32	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.64000112
33	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.62977850
34	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.61394937
35	ECM-receptor interaction_Homo sapiens_hsa04512	0.59968456
36	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.59360466
37	Cholinergic synapse_Homo sapiens_hsa04725	0.59095232
38	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.59066225
39	Choline metabolism in cancer_Homo sapiens_hsa05231	0.58225601
40	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57300785
41	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.55735205
42	Malaria_Homo sapiens_hsa05144	0.54101124
43	GnRH signaling pathway_Homo sapiens_hsa04912	0.54071805
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.53380790
45	Salmonella infection_Homo sapiens_hsa05132	0.52973891
46	Nicotine addiction_Homo sapiens_hsa05033	0.52638318
47	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.48898165
48	TNF signaling pathway_Homo sapiens_hsa04668	0.47300802
49	Toxoplasmosis_Homo sapiens_hsa05145	0.46185782
50	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.44622295
51	Caffeine metabolism_Homo sapiens_hsa00232	0.44515056
52	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.41736325
53	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.41711238
54	Protein digestion and absorption_Homo sapiens_hsa04974	0.40891111
55	Retinol metabolism_Homo sapiens_hsa00830	0.40802346
56	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.36985186
57	Linoleic acid metabolism_Homo sapiens_hsa00591	0.34103307
58	Nitrogen metabolism_Homo sapiens_hsa00910	0.33805320
59	Pyrimidine metabolism_Homo sapiens_hsa00240	0.33406466
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.32225045
61	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.30907910
62	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.30151158
63	African trypanosomiasis_Homo sapiens_hsa05143	0.29522945
64	Asthma_Homo sapiens_hsa05310	0.28432667
65	Graft-versus-host disease_Homo sapiens_hsa05332	0.25902993
66	Phagosome_Homo sapiens_hsa04145	0.25618447
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.24723937
68	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.23677152
69	Chemical carcinogenesis_Homo sapiens_hsa05204	0.23441042
70	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.22936079
71	Phototransduction_Homo sapiens_hsa04744	0.21755944
72	Allograft rejection_Homo sapiens_hsa05330	0.21591111
73	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.20808053
74	MAPK signaling pathway_Homo sapiens_hsa04010	0.20544362
75	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.20275186
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.19641019
77	Fat digestion and absorption_Homo sapiens_hsa04975	0.19537335
78	RNA transport_Homo sapiens_hsa03013	0.19426948
79	Rap1 signaling pathway_Homo sapiens_hsa04015	0.19029328
80	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.18778288
81	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.18632320
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.18317945
83	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.18072781
84	Tyrosine metabolism_Homo sapiens_hsa00350	0.17702677
85	Purine metabolism_Homo sapiens_hsa00230	0.17639715
86	Influenza A_Homo sapiens_hsa05164	0.16427717
87	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.15987733
88	Tuberculosis_Homo sapiens_hsa05152	0.15205210
89	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.14748389
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.14646280
91	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.14181603
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.13865688
93	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.13017907
94	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.12681519
95	Pancreatic secretion_Homo sapiens_hsa04972	0.11186415
96	Bile secretion_Homo sapiens_hsa04976	0.10776091
97	Salivary secretion_Homo sapiens_hsa04970	0.09879102
98	Serotonergic synapse_Homo sapiens_hsa04726	0.09357063
99	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.08156448
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.05510045

TMED10P2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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