ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein-cofactor linkage (GO:0018065)	7.90071243
2	astrocyte development (GO:0014002)	5.63151381
3	regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)	4.70892418
4	cornea development in camera-type eye (GO:0061303)	4.69437554
5	xenobiotic catabolic process (GO:0042178)	4.38251076
6	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.30877678
7	regulation of acyl-CoA biosynthetic process (GO:0050812)	4.30152420
8	positive regulation of smooth muscle cell migration (GO:0014911)	4.26844720
9	cellular response to zinc ion (GO:0071294)	4.15047991
10	cellular response to gamma radiation (GO:0071480)	3.99562060
11	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	3.91947886
12	mesenchymal-epithelial cell signaling (GO:0060638)	3.84116745
13	hepatocyte apoptotic process (GO:0097284)	3.83460521
14	nucleobase biosynthetic process (GO:0046112)	3.80666379
15	cobalamin metabolic process (GO:0009235)	3.69430073
16	platelet dense granule organization (GO:0060155)	3.68200451
17	anterograde synaptic vesicle transport (GO:0048490)	3.65699928
18	adenosine metabolic process (GO:0046085)	3.64026777
19	regulation of sister chromatid cohesion (GO:0007063)	3.61717975
20	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.59514855
21	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.59514855
22	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.59514855
23	peptidyl-histidine modification (GO:0018202)	3.54189551
24	indolalkylamine metabolic process (GO:0006586)	3.53390545
25	digestion (GO:0007586)	3.53234067
26	regulation of sulfur metabolic process (GO:0042762)	3.52403482
27	intestinal cholesterol absorption (GO:0030299)	3.50061691
28	response to nitrosative stress (GO:0051409)	3.43574283
29	endosome to pigment granule transport (GO:0043485)	3.43477231
30	endosome to melanosome transport (GO:0035646)	3.43477231
31	kidney morphogenesis (GO:0060993)	3.41770117
32	regulation of cofactor metabolic process (GO:0051193)	3.37231299
33	regulation of coenzyme metabolic process (GO:0051196)	3.37231299
34	keratan sulfate catabolic process (GO:0042340)	3.36375999
35	developmental pigmentation (GO:0048066)	3.35564599
36	response to redox state (GO:0051775)	3.25440200
37	negative regulation of transcription by competitive promoter binding (GO:0010944)	3.23934821
38	positive regulation of histone H3-K4 methylation (GO:0051571)	3.22287970
39	histamine secretion (GO:0001821)	3.20816955
40	regulation of acute inflammatory response to antigenic stimulus (GO:0002864)	3.17700217
41	prostate gland growth (GO:0060736)	3.16057422
42	regulation of type B pancreatic cell apoptotic process (GO:2000674)	3.15334672
43	respiratory chain complex IV assembly (GO:0008535)	3.13894959
44	phosphatidylinositol acyl-chain remodeling (GO:0036149)	3.12527396
45	positive regulation of glycolytic process (GO:0045821)	3.11195914
46	lactate metabolic process (GO:0006089)	3.10177944
47	aldehyde catabolic process (GO:0046185)	3.09421175
48	secretory granule organization (GO:0033363)	3.08145424
49	proteasome assembly (GO:0043248)	3.06166673
50	protein localization to cilium (GO:0061512)	3.04372320
51	mannosylation (GO:0097502)	2.97354480
52	piRNA metabolic process (GO:0034587)	2.94610430
53	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.93645066
54	retina vasculature morphogenesis in camera-type eye (GO:0061299)	2.88708581
55	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	2.88314224
56	dicarboxylic acid catabolic process (GO:0043649)	2.87841018
57	positive regulation of cell cycle G1/S phase transition (GO:1902808)	2.86587170
58	purine nucleobase biosynthetic process (GO:0009113)	2.84984289
59	indolalkylamine catabolic process (GO:0046218)	2.81140769
60	tryptophan catabolic process (GO:0006569)	2.81140769
61	indole-containing compound catabolic process (GO:0042436)	2.81140769
62	chondroitin sulfate catabolic process (GO:0030207)	2.81012929
63	negative regulation of acute inflammatory response (GO:0002674)	2.80649027
64	negative regulation of epidermal cell differentiation (GO:0045605)	2.80179676
65	cytochrome complex assembly (GO:0017004)	2.76149776
66	artery smooth muscle contraction (GO:0014824)	2.75939470
67	protein K11-linked deubiquitination (GO:0035871)	2.73051825
68	purine-containing compound salvage (GO:0043101)	2.71206484
69	negative regulation of inflammatory response to antigenic stimulus (GO:0002862)	2.71031770
70	azole transport (GO:0045117)	2.67185948
71	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	2.64931063
72	mitochondrial respiratory chain complex assembly (GO:0033108)	2.64191745
73	phosphatidylserine acyl-chain remodeling (GO:0036150)	2.64120998
74	negative regulation of T cell differentiation in thymus (GO:0033085)	2.63149597
75	histamine transport (GO:0051608)	2.62054546
76	positive regulation of protein autophosphorylation (GO:0031954)	2.60176973
77	synapsis (GO:0007129)	2.57623681
78	protein K6-linked ubiquitination (GO:0085020)	2.57121995
79	negative regulation of cation channel activity (GO:2001258)	2.56453199
80	lung secretory cell differentiation (GO:0061140)	2.55472678
81	regulation of phospholipase A2 activity (GO:0032429)	2.53566058
82	detection of calcium ion (GO:0005513)	2.53558840
83	exocrine pancreas development (GO:0031017)	2.52787263
84	negative chemotaxis (GO:0050919)	2.52284673
85	cellular ketone body metabolic process (GO:0046950)	2.52069523
86	inner ear receptor cell development (GO:0060119)	2.51153572
87	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.50414923
88	termination of RNA polymerase III transcription (GO:0006386)	2.50414923
89	fatty acid elongation (GO:0030497)	2.50056227
90	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	2.49592898
91	purine nucleotide salvage (GO:0032261)	2.49227136
92	smooth muscle tissue development (GO:0048745)	2.48812231
93	tryptophan metabolic process (GO:0006568)	2.48526821
94	myoblast differentiation (GO:0045445)	2.47763898
95	cilium morphogenesis (GO:0060271)	2.47524238
96	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	2.46336103
97	cullin deneddylation (GO:0010388)	2.46166305
98	indole-containing compound metabolic process (GO:0042430)	2.46003894
99	drug transmembrane transport (GO:0006855)	2.45320499
100	viral protein processing (GO:0019082)	2.44863334

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.04492144
2	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.30420679
3	VDR_22108803_ChIP-Seq_LS180_Human	3.39848423
4	SALL1_21062744_ChIP-ChIP_HESCs_Human	3.15108430
5	ZNF274_21170338_ChIP-Seq_K562_Hela	2.71735664
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.52708299
7	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.41264757
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.33044240
9	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.31013458
10	BCAT_22108803_ChIP-Seq_LS180_Human	2.28587258
11	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.27891900
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23262915
13	P300_19829295_ChIP-Seq_ESCs_Human	2.19915606
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.19468302
15	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.16899796
16	TAF15_26573619_Chip-Seq_HEK293_Human	2.00219257
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99399429
18	EWS_26573619_Chip-Seq_HEK293_Human	1.98048215
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.91982726
20	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87406458
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.84193269
22	CBP_20019798_ChIP-Seq_JUKART_Human	1.84193269
23	IGF1R_20145208_ChIP-Seq_DFB_Human	1.83232197
24	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.82524122
25	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.77043872
26	ER_23166858_ChIP-Seq_MCF-7_Human	1.75128570
27	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.70457429
28	FUS_26573619_Chip-Seq_HEK293_Human	1.64782691
29	SMAD4_21799915_ChIP-Seq_A2780_Human	1.62377199
30	ELK1_19687146_ChIP-ChIP_HELA_Human	1.61317351
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.59950787
32	AR_25329375_ChIP-Seq_VCAP_Human	1.59444506
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.59089344
34	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.58028930
35	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.56124118
36	CDX2_22108803_ChIP-Seq_LS180_Human	1.54593288
37	STAT3_23295773_ChIP-Seq_U87_Human	1.49906281
38	SOX2_19829295_ChIP-Seq_ESCs_Human	1.45752101
39	NANOG_19829295_ChIP-Seq_ESCs_Human	1.45752101
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.44354157
41	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.43691796
42	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.41914151
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.41670329
44	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41514620
45	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.40331621
46	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.40275927
47	TCF4_22108803_ChIP-Seq_LS180_Human	1.39689261
48	TCF4_23295773_ChIP-Seq_U87_Human	1.37164175
49	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.36583973
50	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.35856614
51	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.34026838
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.33734905
53	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.33463613
54	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31525095
55	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.31265819
56	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.31129261
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.30796072
58	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.30370376
59	AR_20517297_ChIP-Seq_VCAP_Human	1.30251044
60	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.30240181
61	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.30094282
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.30094282
63	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.29347040
64	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.26206766
65	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.25614771
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.25535482
67	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.25158406
68	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.24585044
69	P53_22387025_ChIP-Seq_ESCs_Mouse	1.24106782
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.23172460
71	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.22339864
72	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.22313564
73	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21655401
74	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.21389222
75	TP53_22573176_ChIP-Seq_HFKS_Human	1.18971681
76	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.18035576
77	RUNX2_22187159_ChIP-Seq_PCA_Human	1.17504434
78	RXR_22108803_ChIP-Seq_LS180_Human	1.17350686
79	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.16493857
80	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.14191672
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.14180056
82	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.13519231
83	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.12820083
84	HOXB7_26014856_ChIP-Seq_BT474_Human	1.12802529
85	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12158189
86	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.12003927
87	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.09312571
88	GATA3_26560356_Chip-Seq_TH2_Human	1.08268210
89	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.08244473
90	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06852962
91	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.05657270
92	RUNX1_27457419_Chip-Seq_LIVER_Mouse	1.02389392
93	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01418277
94	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.01158755
95	HTT_18923047_ChIP-ChIP_STHdh_Human	1.00275515
96	NMYC_18555785_Chip-Seq_ESCs_Mouse	0.98618881
97	P300_18555785_Chip-Seq_ESCs_Mouse	0.98588401
98	PU1_27457419_Chip-Seq_LIVER_Mouse	0.96425427
99	CTCF_18555785_Chip-Seq_ESCs_Mouse	0.95492259
100	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.94464824

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	5.00119299
2	MP0006072_abnormal_retinal_apoptosis	4.21010999
3	MP0008877_abnormal_DNA_methylation	4.20387488
4	MP0003787_abnormal_imprinting	4.19196095
5	MP0003656_abnormal_erythrocyte_physiolo	3.20033023
6	MP0002102_abnormal_ear_morphology	2.96310608
7	MP0005367_renal/urinary_system_phenotyp	2.94227706
8	MP0000516_abnormal_urinary_system	2.94227706
9	MP0002009_preneoplasia	2.89839049
10	MP0003283_abnormal_digestive_organ	2.87286965
11	MP0005379_endocrine/exocrine_gland_phen	2.62746626
12	MP0001666_abnormal_nutrient_absorption	2.35531613
13	MP0003300_gastrointestinal_ulcer	2.32843442
14	MP0002166_altered_tumor_susceptibility	2.32150366
15	MP0002163_abnormal_gland_morphology	2.26091731
16	MP0002837_dystrophic_cardiac_calcinosis	2.21293448
17	MP0005253_abnormal_eye_physiology	2.12125809
18	MP0001764_abnormal_homeostasis	2.08763206
19	MP0003186_abnormal_redox_activity	2.08131442
20	MP0002006_tumorigenesis	2.06238640
21	MP0000569_abnormal_digit_pigmentation	1.93234926
22	MP0005083_abnormal_biliary_tract	1.90290033
23	MP0004264_abnormal_extraembryonic_tissu	1.88380262
24	MP0000015_abnormal_ear_pigmentation	1.87509401
25	MP0003121_genomic_imprinting	1.77497643
26	MP0004134_abnormal_chest_morphology	1.67537251
27	MP0001529_abnormal_vocalization	1.65168397
28	MP0008007_abnormal_cellular_replicative	1.64508916
29	MP0003195_calcinosis	1.62371050
30	MP0005645_abnormal_hypothalamus_physiol	1.60016539
31	MP0010329_abnormal_lipoprotein_level	1.58810524
32	MP0009780_abnormal_chondrocyte_physiolo	1.56584559
33	MP0005084_abnormal_gallbladder_morpholo	1.53797955
34	MP0006054_spinal_hemorrhage	1.51797249
35	MP0005365_abnormal_bile_salt	1.49459280
36	MP0002396_abnormal_hematopoietic_system	1.48269036
37	MP0000427_abnormal_hair_cycle	1.47919157
38	MP0001986_abnormal_taste_sensitivity	1.47500924
39	MP0003011_delayed_dark_adaptation	1.45718659
40	MP0005075_abnormal_melanosome_morpholog	1.42710429
41	MP0003786_premature_aging	1.41085178
42	MP0006036_abnormal_mitochondrial_physio	1.35768421
43	MP0002909_abnormal_adrenal_gland	1.33163924
44	MP0004215_abnormal_myocardial_fiber	1.32005581
45	MP0010234_abnormal_vibrissa_follicle	1.28149716
46	MP0002877_abnormal_melanocyte_morpholog	1.27968623
47	MP0005275_abnormal_skin_tensile	1.24679464
48	MP0005551_abnormal_eye_electrophysiolog	1.21859450
49	MP0002160_abnormal_reproductive_system	1.21301234
50	MP0001270_distended_abdomen	1.19491009
51	MP0003252_abnormal_bile_duct	1.17046314
52	MP0002876_abnormal_thyroid_physiology	1.15217256
53	MP0002090_abnormal_vision	1.14359647
54	MP0008058_abnormal_DNA_repair	1.13072303
55	MP0009697_abnormal_copulation	1.08467492
56	MP0003868_abnormal_feces_composition	1.05063415
57	MP0005220_abnormal_exocrine_pancreas	1.02690340
58	MP0005174_abnormal_tail_pigmentation	1.02533134
59	MP0005408_hypopigmentation	1.01608417
60	MP0005503_abnormal_tendon_morphology	0.97638157
61	MP0001984_abnormal_olfaction	0.96946516
62	MP0004272_abnormal_basement_membrane	0.94343545
63	MP0008872_abnormal_physiological_respon	0.92765992
64	MP0003172_abnormal_lysosome_physiology	0.90550213
65	MP0009046_muscle_twitch	0.88901508
66	MP0002254_reproductive_system_inflammat	0.88016187
67	MP0005389_reproductive_system_phenotype	0.87866688
68	MP0002693_abnormal_pancreas_physiology	0.87054743
69	MP0000647_abnormal_sebaceous_gland	0.84872256
70	MP0005376_homeostasis/metabolism_phenot	0.83097868
71	MP0009764_decreased_sensitivity_to	0.81594717
72	MP0000639_abnormal_adrenal_gland	0.81343757
73	MP0005248_abnormal_Harderian_gland	0.80801589
74	MP0001835_abnormal_antigen_presentation	0.80737170
75	MP0008004_abnormal_stomach_pH	0.80561313
76	MP0002138_abnormal_hepatobiliary_system	0.79915355
77	MP0000013_abnormal_adipose_tissue	0.79817421
78	MP0005332_abnormal_amino_acid	0.77712409
79	MP0001944_abnormal_pancreas_morphology	0.77219693
80	MP0004019_abnormal_vitamin_homeostasis	0.75175998
81	MP0005646_abnormal_pituitary_gland	0.68953213
82	MP0001756_abnormal_urination	0.68787595
83	MP0000230_abnormal_systemic_arterial	0.68279480
84	MP0005266_abnormal_metabolism	0.67983396
85	MP0003943_abnormal_hepatobiliary_system	0.67754769
86	MP0008995_early_reproductive_senescence	0.67749188
87	MP0010094_abnormal_chromosome_stability	0.64262708
88	MP0001542_abnormal_bone_strength	0.61764336
89	MP0004742_abnormal_vestibular_system	0.60113179
90	MP0006035_abnormal_mitochondrial_morpho	0.59319567
91	MP0002928_abnormal_bile_duct	0.59262083
92	MP0010678_abnormal_skin_adnexa	0.58482770
93	MP0000613_abnormal_salivary_gland	0.58099309
94	MP0003633_abnormal_nervous_system	0.57610722
95	MP0003718_maternal_effect	0.55872184
96	MP0002751_abnormal_autonomic_nervous	0.55530055
97	MP0002108_abnormal_muscle_morphology	0.54272244
98	MP0004142_abnormal_muscle_tone	0.53061568
99	MP0002118_abnormal_lipid_homeostasis	0.52710794
100	MP0004484_altered_response_of	0.52606251

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Microglossia (HP:0000171)	5.09921530
2	Metaphyseal dysplasia (HP:0100255)	4.56445542
3	Pancreatic fibrosis (HP:0100732)	4.13288447
4	Short tibia (HP:0005736)	3.92787951
5	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.75357409
6	Cerebellar dysplasia (HP:0007033)	3.62229779
7	Pancreatic cysts (HP:0001737)	3.51673809
8	Retinal atrophy (HP:0001105)	3.42055918
9	Abnormality of lateral ventricle (HP:0030047)	3.16632985
10	Generalized tonic-clonic seizures (HP:0002069)	3.10974157
11	Aplasia/Hypoplasia of the tongue (HP:0010295)	3.05176669
12	Pancreatic islet-cell hyperplasia (HP:0004510)	3.03247607
13	Abnormality of the renal medulla (HP:0100957)	2.93806070
14	Steatorrhea (HP:0002570)	2.81847267
15	Large eyes (HP:0001090)	2.78664795
16	Median cleft lip (HP:0000161)	2.77913324
17	Nephronophthisis (HP:0000090)	2.76975390
18	Molar tooth sign on MRI (HP:0002419)	2.76486890
19	Abnormality of midbrain morphology (HP:0002418)	2.76486890
20	Hyperinsulinemic hypoglycemia (HP:0000825)	2.69597206
21	Megaloblastic anemia (HP:0001889)	2.60882537
22	Acute necrotizing encephalopathy (HP:0006965)	2.60228337
23	Coronal craniosynostosis (HP:0004440)	2.60179084
24	Hypoproteinemia (HP:0003075)	2.60096541
25	Chronic hepatic failure (HP:0100626)	2.58278542
26	Fibular hypoplasia (HP:0003038)	2.55663022
27	Progressive macrocephaly (HP:0004481)	2.53828503
28	Cutaneous melanoma (HP:0012056)	2.50814343
29	Hypothermia (HP:0002045)	2.50235593
30	Stenosis of the external auditory canal (HP:0000402)	2.48040872
31	Ependymoma (HP:0002888)	2.45130543
32	Abnormality of the renal cortex (HP:0011035)	2.45056207
33	Abdominal situs inversus (HP:0003363)	2.43935106
34	Abnormality of abdominal situs (HP:0011620)	2.43935106
35	Tubular atrophy (HP:0000092)	2.43466434
36	Hypomagnesemia (HP:0002917)	2.41215295
37	Abnormality of chromosome segregation (HP:0002916)	2.36073808
38	11 pairs of ribs (HP:0000878)	2.35878777
39	Thyroiditis (HP:0100646)	2.33978594
40	Abnormality of endocrine pancreas physiology (HP:0012093)	2.31254482
41	Abnormality of the pancreatic islet cells (HP:0006476)	2.31254482
42	Enlarged kidneys (HP:0000105)	2.30400890
43	Flat face (HP:0012368)	2.30387952
44	Retinal dysplasia (HP:0007973)	2.30168634
45	Delayed gross motor development (HP:0002194)	2.29440051
46	Abnormality of aspartate family amino acid metabolism (HP:0010899)	2.28060832
47	Hyperglycemia (HP:0003074)	2.27518417
48	Oculomotor apraxia (HP:0000657)	2.25754628
49	Lymphangioma (HP:0100764)	2.25126718
50	Abnormal albumin level (HP:0012116)	2.22627933
51	Hypoalbuminemia (HP:0003073)	2.22627933
52	Polydipsia (HP:0001959)	2.22554789
53	Abnormal drinking behavior (HP:0030082)	2.22554789
54	Ketoacidosis (HP:0001993)	2.18547382
55	Fat malabsorption (HP:0002630)	2.11575223
56	Abnormality of vitamin B metabolism (HP:0004340)	2.10813434
57	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.10198234
58	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.10198234
59	Albinism (HP:0001022)	2.08500705
60	Hemiparesis (HP:0001269)	2.08005464
61	Hypoglycemic seizures (HP:0002173)	2.05873822
62	Acute encephalopathy (HP:0006846)	2.05511901
63	Abnormality of magnesium homeostasis (HP:0004921)	2.04296826
64	Postaxial foot polydactyly (HP:0001830)	2.03682489
65	Absent speech (HP:0001344)	2.03502158
66	Abnormal foot bone ossification (HP:0010675)	2.02557189
67	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.00876703
68	Pachygyria (HP:0001302)	2.00573857
69	Type II lissencephaly (HP:0007260)	2.00401526
70	Abnormal biliary tract physiology (HP:0012439)	1.97020004
71	Bile duct proliferation (HP:0001408)	1.97020004
72	Abnormality of the astrocytes (HP:0100707)	1.96896077
73	Astrocytoma (HP:0009592)	1.96896077
74	Methylmalonic acidemia (HP:0002912)	1.96486695
75	Hamartoma of the eye (HP:0010568)	1.95559979
76	Chorioretinal atrophy (HP:0000533)	1.94855993
77	Neoplasm of the adrenal cortex (HP:0100641)	1.93641617
78	Cystic liver disease (HP:0006706)	1.93055828
79	Polyuria (HP:0000103)	1.92999914
80	Hepatoblastoma (HP:0002884)	1.91958986
81	Aplasia/hypoplasia of the uterus (HP:0008684)	1.91094282
82	Premature ovarian failure (HP:0008209)	1.89384498
83	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.88185029
84	Dyschromatopsia (HP:0007641)	1.86225553
85	Neoplasm of the adrenal gland (HP:0100631)	1.85190444
86	Occipital encephalocele (HP:0002085)	1.84400018
87	Abnormality of the vitreous humor (HP:0004327)	1.83704759
88	Erythroderma (HP:0001019)	1.83337087
89	Large for gestational age (HP:0001520)	1.83272141
90	Hypoplastic iliac wings (HP:0002866)	1.83266086
91	Abnormality of methionine metabolism (HP:0010901)	1.81482357
92	True hermaphroditism (HP:0010459)	1.81214850
93	Abnormal mitochondria in muscle tissue (HP:0008316)	1.81140994
94	Mitochondrial inheritance (HP:0001427)	1.80012645
95	Abnormality of the basal ganglia (HP:0002134)	1.78966215
96	Ankyloglossia (HP:0010296)	1.78836056
97	Resting tremor (HP:0002322)	1.78340965
98	Gastrointestinal atresia (HP:0002589)	1.77861708
99	Methylmalonic aciduria (HP:0012120)	1.77420581
100	Ketosis (HP:0001946)	1.77033520

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.95586471
2	STK16	4.83805040
3	NTRK3	4.40702015
4	MAP3K2	3.70116079
5	DYRK3	2.69503281
6	RPS6KA4	2.51781327
7	KSR2	2.33174621
8	CDK3	2.20599344
9	GRK6	2.09262012
10	MST4	2.04518669
11	MAP3K12	1.98890658
12	MAP4K2	1.91519022
13	GRK1	1.82409056
14	INSRR	1.79972593
15	KSR1	1.73651832
16	BMPR2	1.71298749
17	RAF1	1.57370319
18	SGK2	1.52068953
19	PIK3CA	1.49412450
20	EIF2AK1	1.43749836
21	TNIK	1.37210933
22	PRKCE	1.37096867
23	WNK3	1.26016207
24	ADRBK2	1.22384077
25	OXSR1	1.21999576
26	MAPKAPK3	1.18442901
27	BMPR1B	1.16370615
28	ERBB3	1.15284222
29	DAPK2	1.12183627
30	CDK19	1.09914095
31	FGFR2	1.09332488
32	STK39	1.08887685
33	PINK1	1.08080606
34	MAPK13	1.07629984
35	CAMK2D	1.07401506
36	MYLK	1.06842261
37	HIPK2	1.03670514
38	NUAK1	1.02246308
39	EIF2AK3	1.02146926
40	MAP3K8	1.00887459
41	NLK	1.00563175
42	TRPM7	0.90497528
43	NEK6	0.89184280
44	SGK223	0.85579187
45	SGK494	0.85579187
46	SGK3	0.84862791
47	PDK2	0.82417658
48	PTK2B	0.82180142
49	IKBKB	0.80765583
50	CDK9	0.78765995
51	ZAK	0.76994161
52	DAPK1	0.76476317
53	CDK6	0.72952847
54	MAP3K4	0.71860367
55	STK3	0.70759517
56	CLK1	0.69790113
57	VRK2	0.67270927
58	CCNB1	0.66759129
59	ACVR1B	0.65866653
60	CASK	0.62551487
61	MAPK7	0.61415365
62	STK38L	0.61015909
63	GSK3A	0.58955688
64	FGFR3	0.58687710
65	CAMK4	0.57189708
66	TAOK3	0.55040692
67	RPS6KL1	0.52215844
68	RPS6KC1	0.52215844
69	RPS6KA6	0.52148842
70	WNK4	0.51951438
71	TRIM28	0.51467722
72	CSF1R	0.49120433
73	MINK1	0.47600047
74	MAPKAPK5	0.46025187
75	TLK1	0.45441145
76	MST1R	0.44661242
77	PLK2	0.44020626
78	AKT3	0.41260927
79	ATR	0.41206197
80	RPS6KA2	0.40415715
81	RET	0.39706840
82	CSNK1A1	0.39249683
83	PLK3	0.38545241
84	MAP2K1	0.38221918
85	RPS6KA5	0.37900766
86	GRK5	0.37852398
87	PAK3	0.36663132
88	TGFBR2	0.34737708
89	ILK	0.34481467
90	CDK4	0.33893498
91	DAPK3	0.33226888
92	VRK1	0.33152401
93	SGK1	0.32888994
94	CHEK2	0.32807755
95	MAPKAPK2	0.32164929
96	MAPK11	0.31349265
97	YES1	0.28810664
98	MET	0.28579073
99	PRKCZ	0.27888157
100	PIK3CG	0.26361561

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.84172563
2	Fat digestion and absorption_Homo sapiens_hsa04975	3.59681236
3	Protein export_Homo sapiens_hsa03060	3.05416035
4	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.90670135
5	Fatty acid elongation_Homo sapiens_hsa00062	2.89887611
6	Proteasome_Homo sapiens_hsa03050	2.78702752
7	Pancreatic secretion_Homo sapiens_hsa04972	2.65444231
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.32274858
9	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.27268818
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.23266704
11	Tryptophan metabolism_Homo sapiens_hsa00380	2.09893379
12	Protein digestion and absorption_Homo sapiens_hsa04974	2.04220308
13	Butanoate metabolism_Homo sapiens_hsa00650	2.04184919
14	RNA polymerase_Homo sapiens_hsa03020	1.97316486
15	Oxidative phosphorylation_Homo sapiens_hsa00190	1.94716878
16	Asthma_Homo sapiens_hsa05310	1.69665871
17	Renin secretion_Homo sapiens_hsa04924	1.68789879
18	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.62827548
19	Insulin secretion_Homo sapiens_hsa04911	1.61061253
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.51217588
21	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.48883703
22	Sulfur metabolism_Homo sapiens_hsa00920	1.48471629
23	Ether lipid metabolism_Homo sapiens_hsa00565	1.47679084
24	Type I diabetes mellitus_Homo sapiens_hsa04940	1.45649607
25	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.43438688
26	Parkinsons disease_Homo sapiens_hsa05012	1.42641032
27	Propanoate metabolism_Homo sapiens_hsa00640	1.41911424
28	Fanconi anemia pathway_Homo sapiens_hsa03460	1.41486597
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.38729345
30	Steroid biosynthesis_Homo sapiens_hsa00100	1.32771925
31	Retinol metabolism_Homo sapiens_hsa00830	1.25144712
32	One carbon pool by folate_Homo sapiens_hsa00670	1.21999610
33	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.20858063
34	Circadian rhythm_Homo sapiens_hsa04710	1.19366420
35	Regulation of autophagy_Homo sapiens_hsa04140	1.17563959
36	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.13503862
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.12574462
38	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.09763147
39	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.07604996
40	Phototransduction_Homo sapiens_hsa04744	1.06192825
41	Circadian entrainment_Homo sapiens_hsa04713	0.98801181
42	Olfactory transduction_Homo sapiens_hsa04740	0.98165838
43	Huntingtons disease_Homo sapiens_hsa05016	0.97323964
44	Collecting duct acid secretion_Homo sapiens_hsa04966	0.96475468
45	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.96279994
46	Renin-angiotensin system_Homo sapiens_hsa04614	0.94419018
47	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92872153
48	Chemical carcinogenesis_Homo sapiens_hsa05204	0.90045415
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.87542956
50	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.84686775
51	Alzheimers disease_Homo sapiens_hsa05010	0.82469347
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.76800509
53	Selenocompound metabolism_Homo sapiens_hsa00450	0.76780821
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.75778220
55	Purine metabolism_Homo sapiens_hsa00230	0.73449876
56	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.73314396
57	Fatty acid metabolism_Homo sapiens_hsa01212	0.71583124
58	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70492222
59	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.69993685
60	Toxoplasmosis_Homo sapiens_hsa05145	0.69125296
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.65619260
62	Pertussis_Homo sapiens_hsa05133	0.65523642
63	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.63749635
64	Long-term depression_Homo sapiens_hsa04730	0.63369557
65	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.63006123
66	Melanoma_Homo sapiens_hsa05218	0.59980640
67	Pyrimidine metabolism_Homo sapiens_hsa00240	0.59215585
68	Melanogenesis_Homo sapiens_hsa04916	0.57547698
69	Small cell lung cancer_Homo sapiens_hsa05222	0.57170497
70	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.56581233
71	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55767261
72	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.54687409
73	ECM-receptor interaction_Homo sapiens_hsa04512	0.54606609
74	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.52986242
75	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.51777784
76	Metabolic pathways_Homo sapiens_hsa01100	0.48751513
77	Prostate cancer_Homo sapiens_hsa05215	0.48380129
78	Homologous recombination_Homo sapiens_hsa03440	0.48277821
79	Serotonergic synapse_Homo sapiens_hsa04726	0.47118897
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.46406967
81	Mineral absorption_Homo sapiens_hsa04978	0.45722436
82	Oocyte meiosis_Homo sapiens_hsa04114	0.44776718
83	Basal cell carcinoma_Homo sapiens_hsa05217	0.44241482
84	Amphetamine addiction_Homo sapiens_hsa05031	0.44061917
85	Glutathione metabolism_Homo sapiens_hsa00480	0.44018394
86	Peroxisome_Homo sapiens_hsa04146	0.42821388
87	Nitrogen metabolism_Homo sapiens_hsa00910	0.41595074
88	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.41384172
89	Cocaine addiction_Homo sapiens_hsa05030	0.39420061
90	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37902608
91	Non-homologous end-joining_Homo sapiens_hsa03450	0.37542981
92	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.35044884
93	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.34115028
94	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.32946437
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.32116962
96	Fatty acid degradation_Homo sapiens_hsa00071	0.32056297
97	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.30188984
98	Rheumatoid arthritis_Homo sapiens_hsa05323	0.28875330
99	Dopaminergic synapse_Homo sapiens_hsa04728	0.27410873
100	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.24996499

TMED11P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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