TMED2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* COPI coating of Golgi vesicle (GO:0048205)7.94941088
2* Golgi transport vesicle coating (GO:0048200)7.94941088
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.59211411
4protein retention in ER lumen (GO:0006621)5.97313233
5ribosome assembly (GO:0042255)5.00719611
6signal peptide processing (GO:0006465)4.97689935
7activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.71098388
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.70008764
9positive regulation of nuclease activity (GO:0032075)4.65858281
10regulation of nuclease activity (GO:0032069)4.25583281
11endoplasmic reticulum unfolded protein response (GO:0030968)4.24701276
12sequestering of metal ion (GO:0051238)4.17918178
13* COPII vesicle coating (GO:0048208)4.16335594
14cellular response to unfolded protein (GO:0034620)4.09055853
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02713877
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02713877
174-hydroxyproline metabolic process (GO:0019471)3.99000755
18protein maturation by protein folding (GO:0022417)3.96458734
19UDP-N-acetylglucosamine metabolic process (GO:0006047)3.95561274
20cellular response to topologically incorrect protein (GO:0035967)3.91401695
21ER-nucleus signaling pathway (GO:0006984)3.88617524
22exocrine pancreas development (GO:0031017)3.87079049
23ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.86209253
24proteasome assembly (GO:0043248)3.58536280
25desmosome organization (GO:0002934)3.55783599
26protein N-linked glycosylation via asparagine (GO:0018279)3.52946566
27peptidyl-asparagine modification (GO:0018196)3.51337344
28folic acid-containing compound biosynthetic process (GO:0009396)3.50438911
29valine metabolic process (GO:0006573)3.47006291
30pentose-phosphate shunt (GO:0006098)3.45214432
31nuclear pore complex assembly (GO:0051292)3.43519540
32establishment of integrated proviral latency (GO:0075713)3.42280680
33response to endoplasmic reticulum stress (GO:0034976)3.40456476
34ER overload response (GO:0006983)3.36193277
35nucleobase-containing small molecule interconversion (GO:0015949)3.28092557
36protein N-linked glycosylation (GO:0006487)3.25577266
37antigen processing and presentation of endogenous antigen (GO:0019883)3.25303067
38* vesicle coating (GO:0006901)3.22472191
39NADPH regeneration (GO:0006740)3.16821181
40nuclear pore organization (GO:0006999)3.16725393
41response to unfolded protein (GO:0006986)3.10862262
42protein autoprocessing (GO:0016540)3.10106463
43tRNA aminoacylation for protein translation (GO:0006418)3.04853410
44cell adhesion mediated by integrin (GO:0033627)3.04604455
45tricarboxylic acid metabolic process (GO:0072350)3.03451710
46response to topologically incorrect protein (GO:0035966)3.01005839
47regulation of translational termination (GO:0006449)2.96340884
48amino acid activation (GO:0043038)2.94377020
49tRNA aminoacylation (GO:0043039)2.94377020
50negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.93126498
51establishment of viral latency (GO:0019043)2.92144031
52regulation of cellular amino acid metabolic process (GO:0006521)2.90258390
53regulation of translational fidelity (GO:0006450)2.86129508
54peptidyl-proline hydroxylation (GO:0019511)2.84656756
55regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84318653
56endocrine pancreas development (GO:0031018)2.84133053
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.78307454
58negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74698786
59negative regulation of ligase activity (GO:0051352)2.74698786
60formation of translation preinitiation complex (GO:0001731)2.72607961
61intestinal cholesterol absorption (GO:0030299)2.72534430
62pteridine-containing compound biosynthetic process (GO:0042559)2.71085503
63tricarboxylic acid cycle (GO:0006099)2.70142202
64anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69389560
65cell redox homeostasis (GO:0045454)2.68054889
66SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.67168689
67bundle of His cell to Purkinje myocyte communication (GO:0086069)2.67152402
68proline biosynthetic process (GO:0006561)2.66667054
69cellular response to vitamin D (GO:0071305)2.65328744
70apoptotic cell clearance (GO:0043277)2.64334201
71low-density lipoprotein particle clearance (GO:0034383)2.63954603
72membrane budding (GO:0006900)2.63220472
73sulfur amino acid catabolic process (GO:0000098)2.62987840
74regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.61692017
75protein targeting to ER (GO:0045047)2.61141097
76peptide catabolic process (GO:0043171)2.60891935
77regulation of metalloenzyme activity (GO:0048552)2.59038712
78* ER to Golgi vesicle-mediated transport (GO:0006888)2.58513964
79cotranslational protein targeting to membrane (GO:0006613)2.56634886
80Arp2/3 complex-mediated actin nucleation (GO:0034314)2.55731078
81cysteine metabolic process (GO:0006534)2.54530101
82regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.54217349
83pore complex assembly (GO:0046931)2.53685106
84nucleotide-sugar biosynthetic process (GO:0009226)2.53197281
85glucose catabolic process (GO:0006007)2.53125903
86DNA unwinding involved in DNA replication (GO:0006268)2.52468042
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.51346659
88peptide hormone processing (GO:0016486)2.51148194
89protein localization to endoplasmic reticulum (GO:0070972)2.50023402
90protein hydroxylation (GO:0018126)2.48678798
91regulation of type B pancreatic cell apoptotic process (GO:2000674)2.46226527
92DNA strand elongation involved in DNA replication (GO:0006271)2.45452670
93proline metabolic process (GO:0006560)2.44964507
94nucleotide-sugar metabolic process (GO:0009225)2.44843616
95regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.44604414
96protein deneddylation (GO:0000338)2.44352462
97negative regulation of glycoprotein biosynthetic process (GO:0010561)2.44019334
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.43236595
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.42407914
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.42407914
101mitochondrial DNA replication (GO:0006264)2.42186473
102lysine catabolic process (GO:0006554)2.42182748
103lysine metabolic process (GO:0006553)2.42182748
104dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.41081439
105AMP metabolic process (GO:0046033)2.40559589
106cellular response to vitamin (GO:0071295)2.39996629
107signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39764428
108signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39764428
109signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39764428
110antigen processing and presentation via MHC class Ib (GO:0002475)2.39641801
111erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.39218390
112L-phenylalanine metabolic process (GO:0006558)2.39218390
113DNA strand elongation (GO:0022616)2.38863727
114protein carboxylation (GO:0018214)2.38713314
115peptidyl-glutamic acid carboxylation (GO:0017187)2.38713314
116DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.38646508
117hemidesmosome assembly (GO:0031581)2.37447211
118signal transduction involved in DNA damage checkpoint (GO:0072422)2.36465158
119signal transduction involved in DNA integrity checkpoint (GO:0072401)2.36465158
120protein complex localization (GO:0031503)2.34958806
121folic acid metabolic process (GO:0046655)2.34727000
122L-phenylalanine catabolic process (GO:0006559)2.34572792
123erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34572792
124deoxyribonucleotide biosynthetic process (GO:0009263)2.33954009
125cellular protein complex localization (GO:0034629)2.33198124
126intestinal epithelial cell development (GO:0060576)2.32222732
127glutamine family amino acid biosynthetic process (GO:0009084)2.31086326
128mitotic nuclear envelope reassembly (GO:0007084)2.31025009
129nuclear envelope reassembly (GO:0031468)2.31025009
130telomere maintenance via semi-conservative replication (GO:0032201)2.30668753
131positive regulation of ligase activity (GO:0051351)2.30301928
132purine ribonucleotide transport (GO:0015868)2.30244486
133skin morphogenesis (GO:0043589)2.29334794
134regulation of ubiquitin-protein transferase activity (GO:0051438)2.29078021
135regulation of translational elongation (GO:0006448)2.28495182
136alpha-linolenic acid metabolic process (GO:0036109)2.28493367
137* Golgi organization (GO:0007030)2.28302870
138de novo protein folding (GO:0006458)2.27949034
139mitotic metaphase plate congression (GO:0007080)2.27900801
140L-serine metabolic process (GO:0006563)2.27804445
141signal transduction involved in cell cycle checkpoint (GO:0072395)2.27637722
142tetrahydrofolate metabolic process (GO:0046653)2.27119226
143L-alpha-amino acid transmembrane transport (GO:1902475)2.25611030
144cullin deneddylation (GO:0010388)2.24890715
145zinc ion transmembrane transport (GO:0071577)2.24770310
146non-recombinational repair (GO:0000726)2.24741740
147positive regulation of glycoprotein metabolic process (GO:1903020)2.20836407
148intestinal absorption (GO:0050892)2.18493499
149mitochondrial calcium ion transport (GO:0006851)2.17930846
150cellular zinc ion homeostasis (GO:0006882)2.17206459
151chaperone-mediated protein folding (GO:0061077)2.16288429
152NADP metabolic process (GO:0006739)2.14500584
153glandular epithelial cell differentiation (GO:0002067)2.12913242
154localization within membrane (GO:0051668)2.11220174
155keratan sulfate catabolic process (GO:0042340)2.08557931
156cellular response to nutrient (GO:0031670)2.08483973
1572-oxoglutarate metabolic process (GO:0006103)2.08220978
158DNA deamination (GO:0045006)2.07897187
159serine family amino acid biosynthetic process (GO:0009070)2.07631622
160maintenance of protein localization in organelle (GO:0072595)2.07278817
161lipopolysaccharide biosynthetic process (GO:0009103)2.06004728
162GDP-mannose metabolic process (GO:0019673)2.05062286
163positive regulation of glycolytic process (GO:0045821)2.04963554
164positive regulation of fatty acid biosynthetic process (GO:0045723)2.03553497
165negative regulation of glycoprotein metabolic process (GO:1903019)2.03142541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92882522
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.45565593
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09923632
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92219854
5E2F7_22180533_ChIP-Seq_HELA_Human2.83840528
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.65269613
7CLOCK_20551151_ChIP-Seq_293T_Human2.52230654
8EGR1_19374776_ChIP-ChIP_THP-1_Human2.50807588
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.46308403
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.42388689
11GATA1_22025678_ChIP-Seq_K562_Human2.25916802
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.23565197
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.16309966
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11785577
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.09924581
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.09802199
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05778760
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.04031161
19* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94190764
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93630323
21* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.92954899
22PADI4_21655091_ChIP-ChIP_MCF-7_Human1.86953893
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.85832635
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.84824189
25MYC_22102868_ChIP-Seq_BL_Human1.84129221
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.81636189
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.77900369
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77899666
29* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.69399425
30TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66908170
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66084577
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.65916941
33AR_21909140_ChIP-Seq_LNCAP_Human1.63886946
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.63621396
35STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59547242
36FOXM1_23109430_ChIP-Seq_U2OS_Human1.58280140
37TFEB_21752829_ChIP-Seq_HELA_Human1.58175489
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.54853419
39NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53997103
40CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50639800
41ERG_20887958_ChIP-Seq_HPC-7_Mouse1.48662330
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48402107
43HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.46157274
44MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46003016
45SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44056846
46SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44056846
47KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.41622501
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41510047
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41138501
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40481021
51EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.38738029
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38513297
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38310964
54DCP1A_22483619_ChIP-Seq_HELA_Human1.37579815
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37526345
56BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37262511
57SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.36189737
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.35773930
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34407101
60* SOX17_20123909_ChIP-Seq_XEN_Mouse1.34150343
61VDR_21846776_ChIP-Seq_THP-1_Human1.32448304
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31545990
63GABP_19822575_ChIP-Seq_HepG2_Human1.31439498
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.30720375
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.30680618
66* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.29232219
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29048634
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.28727569
69ATF3_27146783_Chip-Seq_COLON_Human1.27142343
70* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.26552768
71* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26408355
72ZNF263_19887448_ChIP-Seq_K562_Human1.26341032
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26098200
74ETS1_20019798_ChIP-Seq_JURKAT_Human1.25488740
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.25381313
76POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.24642593
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.24395390
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23892970
79VDR_23849224_ChIP-Seq_CD4+_Human1.23089745
80POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22929369
81ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22563338
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.21739762
83* TTF2_22483619_ChIP-Seq_HELA_Human1.21073919
84* FOXP3_21729870_ChIP-Seq_TREG_Human1.20078125
85ESR1_21235772_ChIP-Seq_MCF-7_Human1.18708865
86ELF5_23300383_ChIP-Seq_T47D_Human1.18676558
87XRN2_22483619_ChIP-Seq_HELA_Human1.18666308
88PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17964156
89* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17715413
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.17121297
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.16913683
92SPI1_23547873_ChIP-Seq_NB4_Human1.16755671
93PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15578649
94* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15540614
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15420996
96ELK3_25401928_ChIP-Seq_HUVEC_Human1.15328670
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.13916342
98MYB_26560356_Chip-Seq_TH2_Human1.12860421
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.12154694
100ELK1_19687146_ChIP-ChIP_HELA_Human1.11813942
101HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.10913460
102* CHD1_26751641_Chip-Seq_LNCaP_Human1.10831353
103GATA3_24758297_ChIP-Seq_MCF-7_Human1.10479474
104ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10391276
105SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09922063
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09681363
107RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09257967
108NANOG_18555785_ChIP-Seq_MESCs_Mouse1.08982855
109EST1_17652178_ChIP-ChIP_JURKAT_Human1.08812504
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08796617
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08584836
112GATA4_25053715_ChIP-Seq_YYC3_Human1.08147391
113HIF1A_21447827_ChIP-Seq_MCF-7_Human1.07267047
114TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06739429
115DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06422827
116* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06397489
117KDM5A_27292631_Chip-Seq_BREAST_Human1.05956369
118E2F1_21310950_ChIP-Seq_MCF-7_Human1.05802973
119* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05794258
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04653653
121KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04620733
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04008137
123* MAF_26560356_Chip-Seq_TH1_Human1.03395822
124FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.03301447
125* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.03252397
126VDR_24763502_ChIP-Seq_THP-1_Human1.03207448
127* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.03116915
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02935053
129TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02637598
130IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02186464
131TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.01719948
132MYB_26560356_Chip-Seq_TH1_Human1.01661794
133UTX_26944678_Chip-Seq_JUKART_Human1.00372439
134GATA6_25053715_ChIP-Seq_YYC3_Human1.00060712
135CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99331623
136* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.98782950
137SOX2_20726797_ChIP-Seq_SW620_Human0.98747085
138WT1_19549856_ChIP-ChIP_CCG9911_Human0.98556392
139ELK1_22589737_ChIP-Seq_MCF10A_Human0.98345978
140RUNX1_22412390_ChIP-Seq_EML_Mouse0.98074634

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage3.15167589
2MP0003941_abnormal_skin_development3.15167415
3MP0008438_abnormal_cutaneous_collagen2.92797187
4MP0002877_abnormal_melanocyte_morpholog2.87197275
5MP0002139_abnormal_hepatobiliary_system2.64809600
6MP0003300_gastrointestinal_ulcer2.52168053
7MP0003705_abnormal_hypodermis_morpholog2.45739872
8MP0005220_abnormal_exocrine_pancreas2.39239396
9MP0002796_impaired_skin_barrier2.30204844
10MP0005365_abnormal_bile_salt2.26600284
11MP0004782_abnormal_surfactant_physiolog2.10964193
12MP0010234_abnormal_vibrissa_follicle2.09240180
13MP0001666_abnormal_nutrient_absorption2.04181235
14MP0009697_abnormal_copulation2.00726308
15MP0010352_gastrointestinal_tract_polyps1.97223441
16MP0003806_abnormal_nucleotide_metabolis1.93036428
17MP0008007_abnormal_cellular_replicative1.91877168
18MP0003195_calcinosis1.87064879
19MP0010094_abnormal_chromosome_stability1.84296990
20MP0008932_abnormal_embryonic_tissue1.83471702
21MP0005058_abnormal_lysosome_morphology1.82222371
22MP0003111_abnormal_nucleus_morphology1.80783187
23MP0005360_urolithiasis1.76014738
24MP0005501_abnormal_skin_physiology1.74207206
25MP0005083_abnormal_biliary_tract1.71969577
26MP0005275_abnormal_skin_tensile1.71691611
27MP0004264_abnormal_extraembryonic_tissu1.70723538
28MP0009840_abnormal_foam_cell1.68296821
29MP0005085_abnormal_gallbladder_physiolo1.61698211
30MP0001944_abnormal_pancreas_morphology1.61116218
31MP0003252_abnormal_bile_duct1.58787692
32MP0005257_abnormal_intraocular_pressure1.56800228
33MP0010678_abnormal_skin_adnexa1.53773254
34MP0003950_abnormal_plasma_membrane1.51925889
35MP0001661_extended_life_span1.50120960
36MP0002693_abnormal_pancreas_physiology1.49471101
37MP0003566_abnormal_cell_adhesion1.48799627
38MP0000013_abnormal_adipose_tissue1.48683436
39MP0003786_premature_aging1.46516048
40MP0009643_abnormal_urine_homeostasis1.46067610
41MP0009384_cardiac_valve_regurgitation1.45439362
42MP0002166_altered_tumor_susceptibility1.44413323
43MP0000537_abnormal_urethra_morphology1.44382102
44MP0003077_abnormal_cell_cycle1.40752591
45MP0001730_embryonic_growth_arrest1.40303886
46MP0000627_abnormal_mammary_gland1.35921726
47MP0002138_abnormal_hepatobiliary_system1.35022391
48MP0004233_abnormal_muscle_weight1.30266182
49MP0001216_abnormal_epidermal_layer1.27830291
50MP0008058_abnormal_DNA_repair1.27469918
51MP0003693_abnormal_embryo_hatching1.25359945
52MP0003183_abnormal_peptide_metabolism1.23855892
53MP0003191_abnormal_cellular_cholesterol1.22434188
54MP0000609_abnormal_liver_physiology1.22352405
55MP0005023_abnormal_wound_healing1.22033805
56MP0003718_maternal_effect1.20547648
57MP0003436_decreased_susceptibility_to1.19491366
58MP0003186_abnormal_redox_activity1.19075473
59MP0000762_abnormal_tongue_morphology1.18250142
60MP0003283_abnormal_digestive_organ1.15452620
61MP0002009_preneoplasia1.15256004
62MP0004272_abnormal_basement_membrane1.15239562
63MP0010368_abnormal_lymphatic_system1.13556016
64MP0003868_abnormal_feces_composition1.13493372
65MP0002896_abnormal_bone_mineralization1.11908960
66MP0004947_skin_inflammation1.09135247
67MP0000350_abnormal_cell_proliferation1.09049560
68MP0002060_abnormal_skin_morphology1.08512120
69MP0010329_abnormal_lipoprotein_level1.08261096
70MP0001533_abnormal_skeleton_physiology1.07481941
71* MP0001672_abnormal_embryogenesis/_devel1.06924681
72* MP0005380_embryogenesis_phenotype1.06924681
73MP0000490_abnormal_crypts_of1.06627961
74MP0000358_abnormal_cell_content/1.06464260
75MP0003221_abnormal_cardiomyocyte_apopto1.05505826
76MP0005623_abnormal_meninges_morphology1.05376167
77* MP0002086_abnormal_extraembryonic_tissu1.02799117
78MP0010771_integument_phenotype1.01885566
79MP0004043_abnormal_pH_regulation1.01584228
80MP0005165_increased_susceptibility_to1.00983714
81* MP0002080_prenatal_lethality1.00551757
82MP0005319_abnormal_enzyme/_coenzyme0.99684628
83* MP0003984_embryonic_growth_retardation0.99260526
84MP0004957_abnormal_blastocyst_morpholog0.98551981
85MP0005408_hypopigmentation0.98444581
86MP0000003_abnormal_adipose_tissue0.97770457
87MP0002098_abnormal_vibrissa_morphology0.97267605
88MP0003315_abnormal_perineum_morphology0.96963465
89MP0000467_abnormal_esophagus_morphology0.96489361
90* MP0002088_abnormal_embryonic_growth/wei0.96464993
91MP0005076_abnormal_cell_differentiation0.96053654
92* MP0001697_abnormal_embryo_size0.96041519
93MP0000377_abnormal_hair_follicle0.95310674
94MP0003656_abnormal_erythrocyte_physiolo0.95203889
95MP0001958_emphysema0.95007910
96MP0000858_altered_metastatic_potential0.94938788
97MP0000685_abnormal_immune_system0.94704092
98MP0000598_abnormal_liver_morphology0.94544865
99MP0001542_abnormal_bone_strength0.94425624
100MP0004185_abnormal_adipocyte_glucose0.94232851
101MP0002078_abnormal_glucose_homeostasis0.94192798
102MP0005636_abnormal_mineral_homeostasis0.93954622
103MP0003795_abnormal_bone_structure0.93296350
104MP0005332_abnormal_amino_acid0.92609380
105MP0001727_abnormal_embryo_implantation0.91814936
106MP0008875_abnormal_xenobiotic_pharmacok0.90887221
107MP0010155_abnormal_intestine_physiology0.90651203
108MP0000465_gastrointestinal_hemorrhage0.89520349
109MP0002909_abnormal_adrenal_gland0.87906644
110MP0001756_abnormal_urination0.87540165
111MP0001243_abnormal_dermal_layer0.87414387
112MP0002928_abnormal_bile_duct0.87093061
113MP0003172_abnormal_lysosome_physiology0.86445577
114MP0002118_abnormal_lipid_homeostasis0.86406474
115* MP0002084_abnormal_developmental_patter0.85271303
116MP0002254_reproductive_system_inflammat0.85222218
117MP0002006_tumorigenesis0.85111842
118MP0001845_abnormal_inflammatory_respons0.84997807
119MP0009672_abnormal_birth_weight0.84383564
120MP0003453_abnormal_keratinocyte_physiol0.84286545
121MP0003279_aneurysm0.84276305
122MP0002933_joint_inflammation0.84155990
123MP0005451_abnormal_body_composition0.82629007
124MP0008260_abnormal_autophagy0.82033099
125MP0008469_abnormal_protein_level0.81927357
126MP0003724_increased_susceptibility_to0.81399986
127MP0010307_abnormal_tumor_latency0.81170207
128MP0001881_abnormal_mammary_gland0.80666136
129MP0005084_abnormal_gallbladder_morpholo0.80602765
130MP0000613_abnormal_salivary_gland0.80274284
131MP0000462_abnormal_digestive_system0.79431317
132MP0005621_abnormal_cell_physiology0.79097444
133MP0005375_adipose_tissue_phenotype0.78892803
134MP0009333_abnormal_splenocyte_physiolog0.78442856
135MP0005464_abnormal_platelet_physiology0.78419960
136MP0000647_abnormal_sebaceous_gland0.77933193
137MP0009780_abnormal_chondrocyte_physiolo0.76901748
138MP0001873_stomach_inflammation0.76733424
139MP0005384_cellular_phenotype0.76676883
140MP0000383_abnormal_hair_follicle0.76530290
141MP0003959_abnormal_lean_body0.76295244
142MP0005503_abnormal_tendon_morphology0.74246467
143MP0005666_abnormal_adipose_tissue0.74157072
144MP0002396_abnormal_hematopoietic_system0.73629088
145MP0001765_abnormal_ion_homeostasis0.72552018
146MP0009785_altered_susceptibility_to0.72302894
147* MP0002085_abnormal_embryonic_tissue0.71726267
148MP0001915_intracranial_hemorrhage0.71608584
149MP0001853_heart_inflammation0.71542826
150MP0000477_abnormal_intestine_morphology0.71524003
151MP0005197_abnormal_uvea_morphology0.68930818
152MP0003866_abnormal_defecation0.67778617
153MP0002419_abnormal_innate_immunity0.67316598
154MP0001849_ear_inflammation0.65801652
155MP0001835_abnormal_antigen_presentation0.64982083
156MP0005390_skeleton_phenotype0.63773498
157MP0003303_peritoneal_inflammation0.63429799
158MP0005025_abnormal_response_to0.63400386
159MP0002136_abnormal_kidney_physiology0.62674062

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)4.71329559
2Hypoglycemic seizures (HP:0002173)3.80169716
3Abnormality of the intrinsic pathway (HP:0010989)3.56861359
4Hyperinsulinemic hypoglycemia (HP:0000825)3.48489698
5Urinary glycosaminoglycan excretion (HP:0003541)3.12967246
6Mucopolysacchariduria (HP:0008155)3.12967246
7Increased serum pyruvate (HP:0003542)3.10443610
8Cervical subluxation (HP:0003308)3.08515389
9Protrusio acetabuli (HP:0003179)3.05216199
10Abnormality of glycolysis (HP:0004366)3.04751437
11Dysostosis multiplex (HP:0000943)3.02804399
12Symptomatic seizures (HP:0011145)2.99959663
13Right ventricular cardiomyopathy (HP:0011663)2.92929464
14Abnormality of aromatic amino acid family metabolism (HP:0004338)2.89366929
15Abnormality of the common coagulation pathway (HP:0010990)2.89027811
16Thoracolumbar scoliosis (HP:0002944)2.86558060
17Premature rupture of membranes (HP:0001788)2.82029125
18Ketoacidosis (HP:0001993)2.79962046
19Abnormality of mucopolysaccharide metabolism (HP:0011020)2.72617217
20Abnormality of polysaccharide metabolism (HP:0011012)2.72617217
21Abnormality of glycosaminoglycan metabolism (HP:0004371)2.72617217
22Generalized aminoaciduria (HP:0002909)2.70175493
23Vacuolated lymphocytes (HP:0001922)2.68664903
24Abnormality of endocrine pancreas physiology (HP:0012093)2.68371628
25Abnormality of the pancreatic islet cells (HP:0006476)2.68371628
26Short nail (HP:0001799)2.67052710
27Late onset (HP:0003584)2.66777271
28Type I transferrin isoform profile (HP:0003642)2.65414100
29Abnormality of the umbilical cord (HP:0010881)2.63115015
30Beaking of vertebral bodies (HP:0004568)2.59420024
31Tetraparesis (HP:0002273)2.57308241
32Selective tooth agenesis (HP:0001592)2.50573590
33Hyperglycemia (HP:0003074)2.49169074
34Abnormal delivery (HP:0001787)2.43935358
35Ketosis (HP:0001946)2.39844133
36Abnormality of methionine metabolism (HP:0010901)2.38597205
37Abnormal umbilical cord blood vessels (HP:0011403)2.37173248
38Single umbilical artery (HP:0001195)2.37173248
39Abnormality of the fetal cardiovascular system (HP:0010948)2.37173248
40Intrahepatic cholestasis (HP:0001406)2.37084788
41Xanthomatosis (HP:0000991)2.35867107
42Abnormalities of placenta or umbilical cord (HP:0001194)2.35069970
43Cardiovascular calcification (HP:0011915)2.34581760
44Conjugated hyperbilirubinemia (HP:0002908)2.31275794
45Insulin resistance (HP:0000855)2.30543651
46Abnormal cartilage morphology (HP:0002763)2.27367698
47Protuberant abdomen (HP:0001538)2.27349703
48Abnormality of monocarboxylic acid metabolism (HP:0010996)2.26927195
49Abdominal distention (HP:0003270)2.26788173
50Thrombocytosis (HP:0001894)2.24001367
51Sparse eyelashes (HP:0000653)2.23799616
52Pancreatic islet-cell hyperplasia (HP:0004510)2.20303741
53Reduced subcutaneous adipose tissue (HP:0003758)2.18767500
54Asymmetry of the thorax (HP:0001555)2.18219578
55Abnormal foot bone ossification (HP:0010675)2.17824087
56Vascular calcification (HP:0004934)2.17020156
57Abnormality of dentin (HP:0010299)2.14852779
58Severe short stature (HP:0003510)2.14305189
59Onycholysis (HP:0001806)2.11876090
60Aortic aneurysm (HP:0004942)2.11767784
61Insulin-resistant diabetes mellitus (HP:0000831)2.10053931
62Cerebral aneurysm (HP:0004944)2.09515281
63Deviation of the thumb (HP:0009603)2.07938883
64Ankle contracture (HP:0006466)2.07696921
65Nonimmune hydrops fetalis (HP:0001790)2.07358917
66Microglossia (HP:0000171)2.06601758
67Wormian bones (HP:0002645)2.06580961
68Abnormal protein N-linked glycosylation (HP:0012347)2.04646961
69Abnormal protein glycosylation (HP:0012346)2.04646961
70Abnormal glycosylation (HP:0012345)2.04646961
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.04646961
72Abnormality of carpal bone ossification (HP:0006257)2.04530266
73Trismus (HP:0000211)2.03211485
74Osteolytic defects of the hand bones (HP:0009699)2.02884686
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.02884686
76Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.02807301
77Deep venous thrombosis (HP:0002625)1.99887427
78Reduced antithrombin III activity (HP:0001976)1.99763287
79Aortic dissection (HP:0002647)1.99673139
80Hyperammonemia (HP:0001987)1.99521300
81Breech presentation (HP:0001623)1.98628056
82Secondary amenorrhea (HP:0000869)1.97432541
83Gout (HP:0001997)1.97029446
84Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96982840
85Degeneration of anterior horn cells (HP:0002398)1.96007735
86Abnormality of the anterior horn cell (HP:0006802)1.96007735
87Vertebral compression fractures (HP:0002953)1.95490151
88Vascular tortuosity (HP:0004948)1.94283702
89Pili torti (HP:0003777)1.93523593
90Interstitial pulmonary disease (HP:0006530)1.93204335
91Joint stiffness (HP:0001387)1.92764363
92Insidious onset (HP:0003587)1.92567237
93Termporal pattern (HP:0011008)1.92567237
94Multiple enchondromatosis (HP:0005701)1.92348117
95Pterygium (HP:0001059)1.92048092
96Microvesicular hepatic steatosis (HP:0001414)1.91094925
97Orthostatic hypotension (HP:0001278)1.90875031
98Arterial tortuosity (HP:0005116)1.90705416
99Hypokinesia (HP:0002375)1.87908008
100Abnormality of oral frenula (HP:0000190)1.87658309
101Abnormality of purine metabolism (HP:0004352)1.86964587
102Peritonitis (HP:0002586)1.86669852
103Follicular hyperkeratosis (HP:0007502)1.86220013
104Abnormal tarsal ossification (HP:0008369)1.86162073
105Abnormality of fatty-acid metabolism (HP:0004359)1.85837515
106Fat malabsorption (HP:0002630)1.85600246
107Elbow flexion contracture (HP:0002987)1.83976847
108Ankyloglossia (HP:0010296)1.83272396
109Increased cerebral lipofuscin (HP:0011813)1.82643365
110Autoamputation (HP:0001218)1.82295358
111Abnormal hair laboratory examination (HP:0003328)1.81467118
112Abnormality of the lumbar spine (HP:0100712)1.81072395
113Microretrognathia (HP:0000308)1.80825165
114Entropion (HP:0000621)1.80282197
115Hypobetalipoproteinemia (HP:0003563)1.80100057
116Abnormality of subcutaneous fat tissue (HP:0001001)1.79504358
117Platyspondyly (HP:0000926)1.79223363
118Breast carcinoma (HP:0003002)1.78562504
119Thin bony cortex (HP:0002753)1.77395978
120Increased neuronal autofluorescent lipopigment (HP:0002074)1.76423139
121Atrophic scars (HP:0001075)1.76275568
122Aneurysm (HP:0002617)1.75474115
123Aplasia/hypoplasia of the humerus (HP:0006507)1.74975962
124Abnormality of the distal phalanges of the toes (HP:0010182)1.74732628
125Septate vagina (HP:0001153)1.74672108
126Proximal placement of thumb (HP:0009623)1.73986157
127Radial bowing (HP:0002986)1.73208292
128Cupped ribs (HP:0000887)1.73050168
129Spastic diplegia (HP:0001264)1.71974025
130Steatorrhea (HP:0002570)1.71696386
131Abnormality of the calcaneus (HP:0008364)1.71182711
132Dry hair (HP:0011359)1.69519512
133Soft skin (HP:0000977)1.68982695
134Dilatation of the ascending aorta (HP:0005111)1.68803828
135Abnormality of transition element cation homeostasis (HP:0011030)1.68692146
136Prolonged partial thromboplastin time (HP:0003645)1.67702221
137Deep philtrum (HP:0002002)1.67618567
138Progressive muscle weakness (HP:0003323)1.67469312
139Alopecia of scalp (HP:0002293)1.67201856
140Flat acetabular roof (HP:0003180)1.66440300
141Back pain (HP:0003418)1.65865144
142Redundant skin (HP:0001582)1.64866150
143Abnormal enzyme/coenzyme activity (HP:0012379)1.64554972
144Exocrine pancreatic insufficiency (HP:0001738)1.64201959
145Shoulder girdle muscle weakness (HP:0003547)1.63956454
146Elevated alkaline phosphatase (HP:0003155)1.63694467
147Palpitations (HP:0001962)1.63388615
148Broad face (HP:0000283)1.62754295
149Abnormality of the acetabulum (HP:0003170)1.62628741
150Blue sclerae (HP:0000592)1.62474728
151Abnormality of alkaline phosphatase activity (HP:0004379)1.62182396
152Rough bone trabeculation (HP:0100670)1.62058519
153Spinal rigidity (HP:0003306)1.61963448
154Short humerus (HP:0005792)1.61916897
155Curly hair (HP:0002212)1.61774988
156Mitral stenosis (HP:0001718)1.61739568
157Abnormality of T cell physiology (HP:0011840)1.59503237
158Coxa valga (HP:0002673)1.57883389
159Metaphyseal cupping (HP:0003021)1.57485896
160Hand muscle atrophy (HP:0009130)1.56281090
161Pancreatitis (HP:0001733)1.56234613
162Hypoplasia of the thymus (HP:0000778)1.55619597
163Ovoid vertebral bodies (HP:0003300)1.55000653
164Skin nodule (HP:0200036)1.54772577
165Epiphyseal dysplasia (HP:0002656)1.53080998

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.01298964
2TRIB33.50964702
3SCYL23.17117472
4PKN22.88877480
5PBK2.88872405
6PASK2.84969943
7SRPK12.77962664
8BCKDK2.77593644
9FLT32.74478282
10NME22.66002658
11TSSK62.33272573
12MAP3K122.19679441
13TTK2.09706001
14TAOK32.03926312
15EIF2AK31.97866743
16TESK11.82845115
17FRK1.81994948
18ERBB31.81921384
19LRRK21.77335583
20SIK11.69580202
21BCR1.66786002
22MAP3K31.66207573
23PTK61.64337612
24KDR1.60303916
25EEF2K1.57498495
26RPS6KA41.56524832
27TRIM281.55786083
28INSRR1.54164756
29TESK21.54076747
30BRSK21.49037416
31JAK31.38339969
32EPHA21.38225293
33MYLK1.37323352
34MAPKAPK31.36792428
35ERBB41.36784565
36PIK3CG1.36298446
37TTN1.35025959
38FGFR41.33962470
39PDGFRA1.30320089
40PDK21.29308112
41ACVR1B1.29098068
42NEK91.26613783
43MAP2K31.25335858
44MAPK151.23566967
45PLK31.22131057
46TBK11.15924061
47PAK41.15109297
48RPS6KB21.12992872
49ZAP701.12306437
50TYK21.09301307
51STK101.08827648
52EIF2AK11.08665748
53MAP3K101.08261521
54LATS21.06621063
55MAP3K21.05542655
56TGFBR11.05533097
57EPHB11.00996944
58MET0.99806657
59LATS10.96706815
60RIPK10.96676945
61HIPK20.96588221
62EIF2AK20.96223659
63TGFBR20.95897333
64SIK30.95813563
65PIM20.95467836
66VRK20.93476354
67STK38L0.93054018
68MAP3K80.92230690
69EPHA30.91594327
70WEE10.88418707
71CAMKK20.88067066
72PTK20.87479367
73PLK10.86951658
74PAK20.85600046
75PLK40.85236420
76CDK70.84748803
77MAP2K20.81436891
78DYRK1B0.81028583
79LIMK10.80644659
80CSNK1A1L0.78767069
81DDR20.78072241
82BTK0.77368704
83CSNK1G30.76223408
84STK240.75931121
85DYRK30.75170993
86LMTK20.74764513
87CDK80.72562423
88MST1R0.71065059
89DAPK10.70639780
90TEC0.70142690
91CSNK1G10.69287361
92ITK0.68687978
93ARAF0.67446601
94JAK20.65727244
95MST40.65358899
96CDK60.65084872
97STK390.64856847
98MAP3K110.63048078
99MAP4K10.62758625
100STK30.62682653
101TAF10.62639833
102AKT30.62587216
103IRAK30.61403832
104STK160.61254311
105NEK20.60973190
106BUB10.60707639
107MAP3K10.59791845
108TRPM70.58885767
109MKNK10.58843967
110KIT0.58026872
111JAK10.57262620
112FER0.55685552
113CLK10.52628803
114ILK0.51716798
115PLK20.51555601
116NEK60.49490998
117PRKCI0.49443815
118MAPK110.48625833
119SMG10.48513332
120AURKB0.47799598
121AURKA0.47282557
122AKT20.46331500
123PRKG20.45372830
124ATR0.45099609
125BRSK10.43459112
126CSK0.42055484
127CDK40.41160541
128CDC70.40605693
129ATM0.39678128
130CHEK20.39634529
131ALK0.38634823
132MAP2K10.38608830
133MTOR0.38393412
134FGFR30.38053177
135FGFR10.37838060
136NEK10.37723006
137CHEK10.37477650
138WNK40.36655915
139NTRK10.36472909
140RET0.35374455
141PDGFRB0.35372077
142PAK30.35301754
143CSF1R0.34727585
144CSNK2A10.34602029
145CSNK1G20.33699184
146ABL20.33043253
147CSNK2A20.32380973
148CDK90.31751170
149GSK3A0.31228784
150IRAK40.31035142
151ZAK0.29448489

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.29319245
2Protein export_Homo sapiens_hsa030604.21790592
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.48116017
4Sulfur metabolism_Homo sapiens_hsa009202.63773396
5Selenocompound metabolism_Homo sapiens_hsa004502.40598399
6N-Glycan biosynthesis_Homo sapiens_hsa005102.28582198
7Folate biosynthesis_Homo sapiens_hsa007902.14171413
8Fatty acid elongation_Homo sapiens_hsa000622.11939368
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03352822
10Non-homologous end-joining_Homo sapiens_hsa034501.94465261
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.78049831
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.73460861
13Fatty acid degradation_Homo sapiens_hsa000711.65446253
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.65178504
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64239380
16Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.63808640
17Other glycan degradation_Homo sapiens_hsa005111.55758507
18Nucleotide excision repair_Homo sapiens_hsa034201.55132996
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.54811710
20Lysosome_Homo sapiens_hsa041421.53929740
21RNA transport_Homo sapiens_hsa030131.52451150
22Steroid biosynthesis_Homo sapiens_hsa001001.51727637
23Caffeine metabolism_Homo sapiens_hsa002321.49972018
24Fat digestion and absorption_Homo sapiens_hsa049751.43892414
25Antigen processing and presentation_Homo sapiens_hsa046121.43271013
26Tryptophan metabolism_Homo sapiens_hsa003801.38831947
27Glycosaminoglycan degradation_Homo sapiens_hsa005311.35544762
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35492089
29Base excision repair_Homo sapiens_hsa034101.32766784
30Vitamin B6 metabolism_Homo sapiens_hsa007501.29063255
31DNA replication_Homo sapiens_hsa030301.27958908
32Cyanoamino acid metabolism_Homo sapiens_hsa004601.24349548
33Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24234352
34Legionellosis_Homo sapiens_hsa051341.22388650
35One carbon pool by folate_Homo sapiens_hsa006701.20916893
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.19044107
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.17155260
38Spliceosome_Homo sapiens_hsa030401.12927243
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.11477582
40Starch and sucrose metabolism_Homo sapiens_hsa005001.08283786
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08019177
42Sulfur relay system_Homo sapiens_hsa041221.05038888
43Protein digestion and absorption_Homo sapiens_hsa049741.03088240
44Renin-angiotensin system_Homo sapiens_hsa046141.00081707
45Pentose phosphate pathway_Homo sapiens_hsa000300.99922023
46Galactose metabolism_Homo sapiens_hsa000520.98935407
47Carbon metabolism_Homo sapiens_hsa012000.97298778
48Propanoate metabolism_Homo sapiens_hsa006400.96863693
49Fatty acid metabolism_Homo sapiens_hsa012120.94190701
502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.94092847
51Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91912550
52Sphingolipid metabolism_Homo sapiens_hsa006000.89134703
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88272826
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87900158
55Biosynthesis of amino acids_Homo sapiens_hsa012300.87073298
56Histidine metabolism_Homo sapiens_hsa003400.85093623
57Bladder cancer_Homo sapiens_hsa052190.83649211
58Peroxisome_Homo sapiens_hsa041460.83472908
59Nitrogen metabolism_Homo sapiens_hsa009100.81545792
60Proteasome_Homo sapiens_hsa030500.79960008
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79817323
62Complement and coagulation cascades_Homo sapiens_hsa046100.78685909
63Small cell lung cancer_Homo sapiens_hsa052220.78563310
64RNA polymerase_Homo sapiens_hsa030200.77952739
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.76648770
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76526220
67Insulin resistance_Homo sapiens_hsa049310.75643980
68Glutathione metabolism_Homo sapiens_hsa004800.74263206
69Tyrosine metabolism_Homo sapiens_hsa003500.71181730
70Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70818394
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70611258
72ECM-receptor interaction_Homo sapiens_hsa045120.69603008
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68204937
74Homologous recombination_Homo sapiens_hsa034400.68204388
75Thyroid cancer_Homo sapiens_hsa052160.67486479
76p53 signaling pathway_Homo sapiens_hsa041150.66621717
77Pyruvate metabolism_Homo sapiens_hsa006200.66267645
78Vibrio cholerae infection_Homo sapiens_hsa051100.63440638
79Arginine and proline metabolism_Homo sapiens_hsa003300.63297783
80Adherens junction_Homo sapiens_hsa045200.62574061
81PPAR signaling pathway_Homo sapiens_hsa033200.61973763
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.61129297
83Metabolic pathways_Homo sapiens_hsa011000.60755546
84Viral carcinogenesis_Homo sapiens_hsa052030.60670612
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.59952271
86Retinol metabolism_Homo sapiens_hsa008300.59500893
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.59124317
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.58732435
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57397276
90beta-Alanine metabolism_Homo sapiens_hsa004100.57199825
91mRNA surveillance pathway_Homo sapiens_hsa030150.55117709
92Ribosome_Homo sapiens_hsa030100.54169306
93Leishmaniasis_Homo sapiens_hsa051400.53983904
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53795035
95Focal adhesion_Homo sapiens_hsa045100.52722628
96Apoptosis_Homo sapiens_hsa042100.52526176
97Basal transcription factors_Homo sapiens_hsa030220.52407647
98Butanoate metabolism_Homo sapiens_hsa006500.52101110
99Purine metabolism_Homo sapiens_hsa002300.51953475
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51587596
101RNA degradation_Homo sapiens_hsa030180.51109438
102Toxoplasmosis_Homo sapiens_hsa051450.49678316
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49637946
104Pyrimidine metabolism_Homo sapiens_hsa002400.49576316
105Chronic myeloid leukemia_Homo sapiens_hsa052200.49494897
106ABC transporters_Homo sapiens_hsa020100.48793543
107Staphylococcus aureus infection_Homo sapiens_hsa051500.48685024
108Pancreatic secretion_Homo sapiens_hsa049720.44688197
109Shigellosis_Homo sapiens_hsa051310.44321454
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.44145085
111Fanconi anemia pathway_Homo sapiens_hsa034600.43585288
112Systemic lupus erythematosus_Homo sapiens_hsa053220.43439760
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.43131704
114TGF-beta signaling pathway_Homo sapiens_hsa043500.43089701
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.42098087
116Phenylalanine metabolism_Homo sapiens_hsa003600.40749814
117Amoebiasis_Homo sapiens_hsa051460.39650775
118Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39123376
119Arginine biosynthesis_Homo sapiens_hsa002200.38419579
120Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38248864
121Chemical carcinogenesis_Homo sapiens_hsa052040.36712242
122Lysine degradation_Homo sapiens_hsa003100.36690524
123Pancreatic cancer_Homo sapiens_hsa052120.36581690
124Pertussis_Homo sapiens_hsa051330.36341329
125Vitamin digestion and absorption_Homo sapiens_hsa049770.34431334
126Glycerolipid metabolism_Homo sapiens_hsa005610.34029314
127Proteoglycans in cancer_Homo sapiens_hsa052050.33266845
128Cell cycle_Homo sapiens_hsa041100.32289666
129Fructose and mannose metabolism_Homo sapiens_hsa000510.32065855
130Mismatch repair_Homo sapiens_hsa034300.31876839
131Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31650357

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