TMED3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)9.58563837
2signal peptide processing (GO:0006465)9.09430604
3protein retention in ER lumen (GO:0006621)8.70289301
4COPII vesicle coating (GO:0048208)6.85366080
5retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)6.84286846
6sequestering of metal ion (GO:0051238)6.27425270
7protein maturation by protein folding (GO:0022417)5.92392080
8activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.76855275
9peptide hormone processing (GO:0016486)5.71683631
10desmosome organization (GO:0002934)5.65558303
11exocrine pancreas development (GO:0031017)5.59746388
12positive regulation of nuclease activity (GO:0032075)5.56221189
13ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.34850647
14GDP-mannose metabolic process (GO:0019673)5.28923869
15protein N-linked glycosylation via asparagine (GO:0018279)5.27120153
16peptidyl-asparagine modification (GO:0018196)5.21211369
17endocrine pancreas development (GO:0031018)5.14183244
18regulation of nuclease activity (GO:0032069)5.09586511
19endoplasmic reticulum unfolded protein response (GO:0030968)4.99088191
20vesicle coating (GO:0006901)4.90715441
21cellular response to unfolded protein (GO:0034620)4.90220231
22regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.89735351
23ER overload response (GO:0006983)4.87262248
24protein N-linked glycosylation (GO:0006487)4.84986051
25cellular response to topologically incorrect protein (GO:0035967)4.77821292
26glandular epithelial cell differentiation (GO:0002067)4.62029035
27ER-nucleus signaling pathway (GO:0006984)4.55394432
28peptide catabolic process (GO:0043171)4.31842961
29regulation of type B pancreatic cell apoptotic process (GO:2000674)4.29177795
30response to endoplasmic reticulum stress (GO:0034976)4.28418761
31UDP-N-acetylglucosamine metabolic process (GO:0006047)4.23964546
32ER to Golgi vesicle-mediated transport (GO:0006888)4.22477733
33protein hydroxylation (GO:0018126)4.04562552
34positive regulation of insulin secretion (GO:0032024)3.94642494
35response to unfolded protein (GO:0006986)3.80760551
36nucleotide-sugar biosynthetic process (GO:0009226)3.79303478
37response to topologically incorrect protein (GO:0035966)3.70762711
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.70019204
39tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.70019204
40type B pancreatic cell development (GO:0003323)3.66329924
41negative regulation of glycoprotein biosynthetic process (GO:0010561)3.63879400
42intra-Golgi vesicle-mediated transport (GO:0006891)3.63547572
43fucose metabolic process (GO:0006004)3.57380498
44nucleotide-sugar metabolic process (GO:0009225)3.57116479
45endosome to pigment granule transport (GO:0043485)3.55191000
46endosome to melanosome transport (GO:0035646)3.55191000
47dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.53580349
48negative regulation of cell size (GO:0045792)3.48454996
49keratan sulfate catabolic process (GO:0042340)3.45907965
50sulfur amino acid catabolic process (GO:0000098)3.45689321
51pteridine-containing compound biosynthetic process (GO:0042559)3.43169371
52nucleoside diphosphate catabolic process (GO:0009134)3.42687451
53folic acid-containing compound biosynthetic process (GO:0009396)3.42026596
54cell redox homeostasis (GO:0045454)3.41215504
55mitochondrial calcium ion transport (GO:0006851)3.40522604
56regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.39553029
57homocysteine metabolic process (GO:0050667)3.38196308
58cellular response to vitamin D (GO:0071305)3.36401494
59lipopolysaccharide biosynthetic process (GO:0009103)3.36214529
60maintenance of protein localization in organelle (GO:0072595)3.35798523
61glandular epithelial cell development (GO:0002068)3.34078300
62regulation of plasminogen activation (GO:0010755)3.31894469
63toxin metabolic process (GO:0009404)3.31370767
64proline biosynthetic process (GO:0006561)3.27965030
65protein autoprocessing (GO:0016540)3.26656054
66positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.24236520
67negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.21187398
68regulation of metalloenzyme activity (GO:0048552)3.20614104
69zinc ion transmembrane transport (GO:0071577)3.19441783
70GMP metabolic process (GO:0046037)3.12939565
71positive regulation of peptide hormone secretion (GO:0090277)3.11944996
72nucleotide transmembrane transport (GO:1901679)3.10420027
73SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10395262
74deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.10230814
75interleukin-1-mediated signaling pathway (GO:0070498)3.07939101
76peptide metabolic process (GO:0006518)3.07401896
77regulation of insulin secretion (GO:0050796)3.03803772
78insulin secretion (GO:0030073)3.03742415
79protein targeting to ER (GO:0045047)3.02993479
80negative regulation of release of cytochrome c from mitochondria (GO:0090201)3.02168749
81cotranslational protein targeting to membrane (GO:0006613)3.00848655
82positive regulation of peptide secretion (GO:0002793)2.94911385
83Golgi vesicle transport (GO:0048193)2.92352164
84amyloid precursor protein catabolic process (GO:0042987)2.91328377
85negative regulation of glycoprotein metabolic process (GO:1903019)2.90266497
86guanosine-containing compound biosynthetic process (GO:1901070)2.90172239
87establishment of protein localization to endoplasmic reticulum (GO:0072599)2.89743236
88L-phenylalanine metabolic process (GO:0006558)2.89706023
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.89706023
90peptidyl-histidine modification (GO:0018202)2.88942543
91cellular zinc ion homeostasis (GO:0006882)2.88435181
92valine metabolic process (GO:0006573)2.87784351
93protein localization to endoplasmic reticulum (GO:0070972)2.86518328
94Golgi organization (GO:0007030)2.85405735
95sphingoid metabolic process (GO:0046519)2.84286056
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.82910798
97antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82910798
98columnar/cuboidal epithelial cell development (GO:0002066)2.80756426
994-hydroxyproline metabolic process (GO:0019471)2.78526528
100type B pancreatic cell proliferation (GO:0044342)2.77861413
101response to testosterone (GO:0033574)2.77487252
102galactose catabolic process (GO:0019388)2.77403022
103aminoglycoside antibiotic metabolic process (GO:0030647)2.77282445
104regulation of peptide hormone secretion (GO:0090276)2.77281519
105peptidyl-proline hydroxylation (GO:0019511)2.76757838
106glycoside metabolic process (GO:0016137)2.76499833
107positive regulation of hormone secretion (GO:0046887)2.74858059
108zinc ion transport (GO:0006829)2.74106397
109protein localization to Golgi apparatus (GO:0034067)2.73199282
110L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72247550
111angiotensin maturation (GO:0002003)2.70351471
112glycolipid catabolic process (GO:0019377)2.69766419
113regulation of peptide secretion (GO:0002791)2.69764516
114pseudouridine synthesis (GO:0001522)2.69305530
115post-translational protein modification (GO:0043687)2.69180786
116regulation of water loss via skin (GO:0033561)2.69113315
117purine nucleotide salvage (GO:0032261)2.68476860
118mannosylation (GO:0097502)2.66620649
119positive regulation of steroid hormone secretion (GO:2000833)2.66086379
120digestion (GO:0007586)2.65748702
121cellular modified amino acid catabolic process (GO:0042219)2.65598088
122regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.64267782
123regulation of hexokinase activity (GO:1903299)2.63697721
124regulation of glucokinase activity (GO:0033131)2.63697721
125mitochondrial RNA metabolic process (GO:0000959)2.62708913
126GTP biosynthetic process (GO:0006183)2.62549353
127galactose metabolic process (GO:0006012)2.61278278
128chaperone-mediated protein folding (GO:0061077)2.61126300
129fucosylation (GO:0036065)2.60374948
130negative regulation of JUN kinase activity (GO:0043508)2.59888631
131nitric oxide biosynthetic process (GO:0006809)2.59654215
132pharyngeal system development (GO:0060037)2.59435208
133glucosamine-containing compound catabolic process (GO:1901072)2.59348734
134negative regulation of keratinocyte proliferation (GO:0010839)2.59286685
135purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.58350386
1363-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.58350386
137skin morphogenesis (GO:0043589)2.54293360
138regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.51599810
139UTP biosynthetic process (GO:0006228)2.51469927
140cysteine metabolic process (GO:0006534)2.49343230
141adenosine metabolic process (GO:0046085)2.47146370
142sphingosine metabolic process (GO:0006670)2.46909935
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.43136904
144lipopolysaccharide metabolic process (GO:0008653)2.41802388
145regulation of integrin-mediated signaling pathway (GO:2001044)2.39656437
146regulation of gonadotropin secretion (GO:0032276)2.39039662
147C-terminal protein lipidation (GO:0006501)2.37705069
148regulation of mitochondrial translation (GO:0070129)2.37182514
149diol metabolic process (GO:0034311)2.35808642
150endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.34863133
151positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.33900124
152protein complex biogenesis (GO:0070271)2.33665154
153UTP metabolic process (GO:0046051)2.33052133
154peptidyl-arginine omega-N-methylation (GO:0035247)2.32769891
155regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.32561312
156glutamine family amino acid biosynthetic process (GO:0009084)2.31977683
157branched-chain amino acid catabolic process (GO:0009083)2.31715024
158nucleotide salvage (GO:0043173)2.30909215
159iron-sulfur cluster assembly (GO:0016226)2.30152340
160metallo-sulfur cluster assembly (GO:0031163)2.30152340
161proline metabolic process (GO:0006560)2.28815317
162negative regulation of mitochondrion organization (GO:0010823)2.28009580
163negative regulation of stem cell proliferation (GO:2000647)2.27189826
164hemidesmosome assembly (GO:0031581)2.27111831
165Golgi transport vesicle coating (GO:0048200)11.9034474
166COPI coating of Golgi vesicle (GO:0048205)11.9034474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse7.09199103
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.28130206
3GATA1_22025678_ChIP-Seq_K562_Human3.96019300
4PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.58535910
5ELF1_17652178_ChIP-ChIP_JURKAT_Human3.35797999
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.35028742
7DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.32348724
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.30343439
9ZNF263_19887448_ChIP-Seq_K562_Human3.30143538
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.15193995
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.12754982
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.90596088
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.72802565
14HIF1A_21447827_ChIP-Seq_MCF-7_Human2.71519992
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68487086
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26394373
17ERG_20887958_ChIP-Seq_HPC-7_Mouse2.22171060
18PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.21544051
19PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.19238735
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.14808923
21DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.09590925
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.02404078
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01701848
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.00456739
25RACK7_27058665_Chip-Seq_MCF-7_Human1.99057719
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.95829290
27* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.95754893
28TFEB_21752829_ChIP-Seq_HELA_Human1.92118276
29SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.92020197
30FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.89162858
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.88554776
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86700148
33MYC_18555785_ChIP-Seq_MESCs_Mouse1.84335174
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.84283398
35TRIM28_21343339_ChIP-Seq_HEK293_Human1.78884244
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73814497
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73126334
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.71390336
39KDM5A_27292631_Chip-Seq_BREAST_Human1.71351744
40* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71246979
41EST1_17652178_ChIP-ChIP_JURKAT_Human1.71156746
42CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.70355685
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.68443747
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.64478813
45PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.61116394
46ATF3_27146783_Chip-Seq_COLON_Human1.59675436
47LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.59504473
48CTCF_18555785_ChIP-Seq_MESCs_Mouse1.58392061
49ESR1_21235772_ChIP-Seq_MCF-7_Human1.57328578
50* LXR_22292898_ChIP-Seq_THP-1_Human1.56194021
51RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.55774361
52GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.51816950
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.50750446
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.50560676
55ETS1_20019798_ChIP-Seq_JURKAT_Human1.49903459
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49788053
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.49642858
58TET1_21451524_ChIP-Seq_MESCs_Mouse1.49476262
59P63_26484246_Chip-Seq_KERATINOCYTES_Human1.49390203
60HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.48445962
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48207626
62* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.45356990
63ELK1_19687146_ChIP-ChIP_HELA_Human1.43496289
64TP53_22127205_ChIP-Seq_IMR90_Human1.43418515
65LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.41902815
66DCP1A_22483619_ChIP-Seq_HELA_Human1.41819552
67* SPI1_23547873_ChIP-Seq_NB4_Human1.41590714
68CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41223605
69SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.40263882
70* SOX2_20726797_ChIP-Seq_SW620_Human1.39790682
71* GABP_19822575_ChIP-Seq_HepG2_Human1.36873577
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.36858071
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35711368
74VDR_23849224_ChIP-Seq_CD4+_Human1.35396825
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.35313214
76ERG_20517297_ChIP-Seq_VCAP_Human1.33857710
77MYC_19030024_ChIP-ChIP_MESCs_Mouse1.33206598
78* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.33178543
79THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31738912
80SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.31097021
81XRN2_22483619_ChIP-Seq_HELA_Human1.30083318
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28718297
83E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28058707
84NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.28058139
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.25412364
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25335677
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24527384
88SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24306135
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24306135
90CLOCK_20551151_ChIP-Seq_293T_Human1.24126698
91AR_20517297_ChIP-Seq_VCAP_Human1.23723126
92CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22802021
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20326545
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20095718
95SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.19010484
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18983249
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.18790815
98PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.18580372
99FOXP3_21729870_ChIP-Seq_TREG_Human1.18511389
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18474337
101NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18287096
102* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17724101
103MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.17720616
104ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.16826910
105CREB1_15753290_ChIP-ChIP_HEK293T_Human1.16352112
106GATA4_25053715_ChIP-Seq_YYC3_Human1.16005289
107TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.15426264
108EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.14938409
109TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14570428
110TBX5_21415370_ChIP-Seq_HL-1_Mouse1.13749718
111STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13618621
112KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13386947
113CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12269869
114P68_20966046_ChIP-Seq_HELA_Human1.12032131
115ELF1_20517297_ChIP-Seq_JURKAT_Human1.11926105
116* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11816416
117GATA3_27048872_Chip-Seq_THYMUS_Human1.11685807
118SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09272920
119GATA2_21666600_ChIP-Seq_HMVEC_Human1.07835485
120STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06253045
121ELF5_23300383_ChIP-Seq_T47D_Human1.04285548
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03397062
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03344432
124FOXP1_21924763_ChIP-Seq_HESCs_Human1.02698973
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02683403
126GATA3_26560356_Chip-Seq_TH2_Human1.02231856
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01231318
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00417914
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.99995934
130GATA6_25053715_ChIP-Seq_YYC3_Human0.99511667
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99425948
132BCOR_27268052_Chip-Seq_Bcells_Human0.98842928
133SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98783357
134TP63_22573176_ChIP-Seq_HFKS_Human0.98444609
135HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.97998532
136TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.97885618
137* FOXA1_25552417_ChIP-Seq_VCAP_Human0.97701286
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.97610506
139VDR_24763502_ChIP-Seq_THP-1_Human0.96909508
140RARB_24833708_ChIP-Seq_LIVER_Mouse0.96800512
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.95926083
142NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95812087
143MYB_26560356_Chip-Seq_TH2_Human0.95800854
144* GATA3_24758297_ChIP-Seq_MCF-7_Human0.95716383
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95424338
146FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.95363875
147SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95299478
148RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.95060117
149AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94830078
150SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94415574
151PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93758206
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93576073
153PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93187814
154PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93050033
155CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90565010
156E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88528171
157PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86578766
158CHD1_26751641_Chip-Seq_LNCaP_Human0.85995462

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.76513146
2MP0002877_abnormal_melanocyte_morpholog4.47911790
3MP0000013_abnormal_adipose_tissue3.99420285
4MP0010386_abnormal_urinary_bladder3.77748660
5MP0005220_abnormal_exocrine_pancreas3.63492360
6MP0003705_abnormal_hypodermis_morpholog3.47695027
7MP0002693_abnormal_pancreas_physiology3.46414144
8MP0004043_abnormal_pH_regulation3.35236394
9MP0001944_abnormal_pancreas_morphology3.24896330
10MP0006054_spinal_hemorrhage3.15557076
11MP0005379_endocrine/exocrine_gland_phen3.08270413
12MP0003195_calcinosis3.00397606
13MP0000678_abnormal_parathyroid_gland2.89850641
14MP0002909_abnormal_adrenal_gland2.80742337
15MP0004272_abnormal_basement_membrane2.49356867
16MP0009840_abnormal_foam_cell2.44675052
17MP0005058_abnormal_lysosome_morphology2.35481277
18MP0009780_abnormal_chondrocyte_physiolo2.34233136
19MP0003806_abnormal_nucleotide_metabolis2.33772221
20MP0004264_abnormal_extraembryonic_tissu2.24261704
21MP0001661_extended_life_span2.21628920
22MP0008438_abnormal_cutaneous_collagen2.21622868
23MP0002837_dystrophic_cardiac_calcinosis2.17679603
24MP0000003_abnormal_adipose_tissue2.14328071
25MP0003283_abnormal_digestive_organ2.14063109
26MP0002796_impaired_skin_barrier1.96880236
27MP0003300_gastrointestinal_ulcer1.94018210
28MP0005084_abnormal_gallbladder_morpholo1.92972132
29MP0003172_abnormal_lysosome_physiology1.87518251
30MP0001986_abnormal_taste_sensitivity1.87092307
31MP0001765_abnormal_ion_homeostasis1.84486503
32MP0004233_abnormal_muscle_weight1.73305744
33MP0000613_abnormal_salivary_gland1.70889882
34MP0002078_abnormal_glucose_homeostasis1.67899021
35MP0005645_abnormal_hypothalamus_physiol1.64604984
36MP0005310_abnormal_salivary_gland1.63288495
37MP0005670_abnormal_white_adipose1.63180993
38MP0001666_abnormal_nutrient_absorption1.61176854
39MP0000371_diluted_coat_color1.60923672
40MP0002896_abnormal_bone_mineralization1.60821638
41MP0000681_abnormal_thyroid_gland1.60472401
42MP0005501_abnormal_skin_physiology1.57735438
43MP0001756_abnormal_urination1.55362824
44MP0009643_abnormal_urine_homeostasis1.53119943
45MP0000516_abnormal_urinary_system1.49283723
46MP0005367_renal/urinary_system_phenotyp1.49283723
47MP0002163_abnormal_gland_morphology1.48530264
48MP0010771_integument_phenotype1.45697977
49MP0005636_abnormal_mineral_homeostasis1.43370621
50MP0002876_abnormal_thyroid_physiology1.43169436
51MP0003279_aneurysm1.41769420
52MP0002160_abnormal_reproductive_system1.38645439
53MP0003959_abnormal_lean_body1.37999976
54MP0005360_urolithiasis1.34637410
55MP0005171_absent_coat_pigmentation1.33789852
56MP0001243_abnormal_dermal_layer1.32552199
57MP0001216_abnormal_epidermal_layer1.32311642
58MP0002166_altered_tumor_susceptibility1.31990618
59MP0003868_abnormal_feces_composition1.31119181
60MP0003724_increased_susceptibility_to1.24869948
61MP0000358_abnormal_cell_content/1.24869251
62MP0002928_abnormal_bile_duct1.24481784
63MP0006072_abnormal_retinal_apoptosis1.23841918
64MP0002098_abnormal_vibrissa_morphology1.23298480
65MP0003566_abnormal_cell_adhesion1.22940244
66MP0005365_abnormal_bile_salt1.22903244
67MP0003795_abnormal_bone_structure1.22732156
68MP0002638_abnormal_pupillary_reflex1.21732907
69MP0005503_abnormal_tendon_morphology1.21699445
70MP0005451_abnormal_body_composition1.21529445
71MP0001270_distended_abdomen1.18596006
72MP0010678_abnormal_skin_adnexa1.18041631
73MP0002736_abnormal_nociception_after1.17978827
74MP0003941_abnormal_skin_development1.17961908
75MP0001533_abnormal_skeleton_physiology1.15201661
76MP0000372_irregular_coat_pigmentation1.15115860
77MP0002075_abnormal_coat/hair_pigmentati1.12956439
78MP0005257_abnormal_intraocular_pressure1.11522767
79MP0009053_abnormal_anal_canal1.10797045
80MP0005623_abnormal_meninges_morphology1.10401498
81MP0002009_preneoplasia1.10106584
82MP0005275_abnormal_skin_tensile1.08115034
83MP0001958_emphysema1.06744433
84MP0005332_abnormal_amino_acid1.06621266
85MP0000015_abnormal_ear_pigmentation1.06356888
86MP0002933_joint_inflammation1.06058261
87MP0004858_abnormal_nervous_system1.05912516
88MP0003953_abnormal_hormone_level1.04831627
89MP0001664_abnormal_digestion1.04298383
90MP0003191_abnormal_cellular_cholesterol1.04018269
91MP0003786_premature_aging1.03116140
92MP0005075_abnormal_melanosome_morpholog1.01846066
93MP0003866_abnormal_defecation1.00631392
94MP0005408_hypopigmentation1.00287644
95MP0000627_abnormal_mammary_gland0.99384498
96MP0003436_decreased_susceptibility_to0.99016217
97MP0004782_abnormal_surfactant_physiolog0.98806920
98MP0000538_abnormal_urinary_bladder0.95318452
99MP0000427_abnormal_hair_cycle0.94330873
100MP0005646_abnormal_pituitary_gland0.93327239
101MP0000163_abnormal_cartilage_morphology0.92858795
102MP0002138_abnormal_hepatobiliary_system0.91673701
103MP0000467_abnormal_esophagus_morphology0.91129743
104MP0003942_abnormal_urinary_system0.88944874
105MP0001764_abnormal_homeostasis0.88627660
106MP0005165_increased_susceptibility_to0.88440009
107MP0002254_reproductive_system_inflammat0.87941651
108MP0002060_abnormal_skin_morphology0.87427945
109MP0005390_skeleton_phenotype0.85360585
110MP0000377_abnormal_hair_follicle0.84390073
111MP0000462_abnormal_digestive_system0.84077388
112MP0000383_abnormal_hair_follicle0.83365244
113MP0001845_abnormal_inflammatory_respons0.82760701
114MP0001873_stomach_inflammation0.82563067
115MP0000534_abnormal_ureter_morphology0.82333835
116MP0002295_abnormal_pulmonary_circulatio0.82058292
117MP0010030_abnormal_orbit_morphology0.81494270
118MP0000230_abnormal_systemic_arterial0.80850523
119MP0005083_abnormal_biliary_tract0.80375705
120MP0005375_adipose_tissue_phenotype0.79018253
121MP0009931_abnormal_skin_appearance0.77696139
122MP0000762_abnormal_tongue_morphology0.77486749
123MP0000367_abnormal_coat/_hair0.76964339
124MP0001919_abnormal_reproductive_system0.76058222
125MP0002148_abnormal_hypersensitivity_rea0.76056120
126MP0005410_abnormal_fertilization0.75967757
127MP0002095_abnormal_skin_pigmentation0.75669159
128MP0000465_gastrointestinal_hemorrhage0.75161298
129MP0008004_abnormal_stomach_pH0.74106548
130MP0002419_abnormal_innate_immunity0.73120218
131MP0003122_maternal_imprinting0.72846633
132MP0005389_reproductive_system_phenotype0.72794350
133MP0004147_increased_porphyrin_level0.71959052
134MP0002998_abnormal_bone_remodeling0.71751098
135MP0000647_abnormal_sebaceous_gland0.71088188
136MP0002938_white_spotting0.70591965
137MP0005023_abnormal_wound_healing0.70473734
138MP0002006_tumorigenesis0.69961217
139MP0000639_abnormal_adrenal_gland0.66693003
140MP0009384_cardiac_valve_regurgitation0.65139193
141MP0001542_abnormal_bone_strength0.64566300
142MP0005508_abnormal_skeleton_morphology0.64504703
143MP0005448_abnormal_energy_balance0.64027781
144MP0000858_altered_metastatic_potential0.62042750
145MP0001835_abnormal_antigen_presentation0.60318766
146MP0010234_abnormal_vibrissa_follicle0.58822370
147MP0009642_abnormal_blood_homeostasis0.58119195
148MP0003186_abnormal_redox_activity0.57594458
149MP0002115_abnormal_skeleton_extremities0.57111300
150MP0000490_abnormal_crypts_of0.57060595
151MP0005000_abnormal_immune_tolerance0.57023325
152MP0001299_abnormal_eye_distance/0.56951111
153MP0008469_abnormal_protein_level0.56904654
154MP0003693_abnormal_embryo_hatching0.56188198
155MP0001881_abnormal_mammary_gland0.55458997
156MP0001186_pigmentation_phenotype0.55306917
157MP0005535_abnormal_body_temperature0.54669965

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic seizures (HP:0002173)5.38490712
2Hyperinsulinemic hypoglycemia (HP:0000825)5.19612582
3Symptomatic seizures (HP:0011145)5.15060612
4Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.00675408
5Hypoglycemic coma (HP:0001325)4.99037747
6Premature rupture of membranes (HP:0001788)4.98145844
7Dysostosis multiplex (HP:0000943)4.37087862
8Abnormal isoelectric focusing of serum transferrin (HP:0003160)4.14886060
9Abnormal protein N-linked glycosylation (HP:0012347)4.14886060
10Abnormal protein glycosylation (HP:0012346)4.14886060
11Abnormal glycosylation (HP:0012345)4.14886060
12Urinary glycosaminoglycan excretion (HP:0003541)4.14579610
13Mucopolysacchariduria (HP:0008155)4.14579610
14Generalized aminoaciduria (HP:0002909)4.13471911
15Type I transferrin isoform profile (HP:0003642)4.04210384
16Abnormality of the intrinsic pathway (HP:0010989)4.01577631
17Vacuolated lymphocytes (HP:0001922)3.98288572
18Abnormality of polysaccharide metabolism (HP:0011012)3.72515192
19Abnormality of glycosaminoglycan metabolism (HP:0004371)3.72515192
20Abnormality of mucopolysaccharide metabolism (HP:0011020)3.72515192
21Abnormality of alanine metabolism (HP:0010916)3.67382944
22Hyperalaninemia (HP:0003348)3.67382944
23Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.67382944
24Abnormality of the pancreatic islet cells (HP:0006476)3.65500696
25Abnormality of endocrine pancreas physiology (HP:0012093)3.65500696
26Abnormality of calcium-phosphate metabolism (HP:0100530)3.59752858
27Large for gestational age (HP:0001520)3.53179774
28Protrusio acetabuli (HP:0003179)3.52686723
29Hyperglycemia (HP:0003074)3.49848131
30Beaking of vertebral bodies (HP:0004568)3.43162073
31Insulin-resistant diabetes mellitus (HP:0000831)3.37863561
32Pancreatic islet-cell hyperplasia (HP:0004510)3.18826840
33Cervical subluxation (HP:0003308)3.11962115
34Ketoacidosis (HP:0001993)3.04615613
35J-shaped sella turcica (HP:0002680)3.00895933
36Reduced antithrombin III activity (HP:0001976)2.98339437
37Late onset (HP:0003584)2.97244557
38Thoracolumbar scoliosis (HP:0002944)2.94081729
39Abnormality of dentin (HP:0010299)2.80272926
40Microretrognathia (HP:0000308)2.77379068
41Hyperparathyroidism (HP:0000843)2.76727676
42Disproportionate short-trunk short stature (HP:0003521)2.74067175
43Atrophic scars (HP:0001075)2.73111983
44Progressive neurologic deterioration (HP:0002344)2.71407311
45Abnormal pancreas size (HP:0012094)2.71096988
46Abnormality of the fetal cardiovascular system (HP:0010948)2.69294674
47Abnormal umbilical cord blood vessels (HP:0011403)2.69294674
48Single umbilical artery (HP:0001195)2.69294674
49Flat capital femoral epiphysis (HP:0003370)2.67270467
50Decreased circulating renin level (HP:0003351)2.57750588
51Thrombocytosis (HP:0001894)2.54483648
52Prolonged neonatal jaundice (HP:0006579)2.52979689
53Hypokinesia (HP:0002375)2.52386599
54Abnormality of the umbilical cord (HP:0010881)2.51774316
55Spondylolisthesis (HP:0003302)2.49269172
56Hypothermia (HP:0002045)2.46606757
57Mitral stenosis (HP:0001718)2.44312022
58Decreased electroretinogram (ERG) amplitude (HP:0000654)2.44225960
59Hyperphosphatemia (HP:0002905)2.44022903
60Irregular vertebral endplates (HP:0003301)2.42386296
61Biconcave vertebral bodies (HP:0004586)2.39094781
62Abdominal distention (HP:0003270)2.38045068
63Hypokalemia (HP:0002900)2.37448509
64Soft skin (HP:0000977)2.36763855
65Epiphyseal dysplasia (HP:0002656)2.34383243
66Fragile skin (HP:0001030)2.33988935
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33168133
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33168133
69Abnormality of the distal phalanges of the toes (HP:0010182)2.32655581
70Short nail (HP:0001799)2.31140287
71Joint stiffness (HP:0001387)2.30787706
72Hypoplasia of the odontoid process (HP:0003311)2.30131207
73Blue sclerae (HP:0000592)2.29496321
74Abnormal foot bone ossification (HP:0010675)2.28524096
75Elbow flexion contracture (HP:0002987)2.27004547
76Retinal atrophy (HP:0001105)2.26617026
77Follicular hyperkeratosis (HP:0007502)2.24816397
78Cardiovascular calcification (HP:0011915)2.24184056
79Insulin resistance (HP:0000855)2.23695161
80Dysautonomia (HP:0002459)2.22374402
81Opisthotonus (HP:0002179)2.20936414
82Agitation (HP:0000713)2.20132712
83Exocrine pancreatic insufficiency (HP:0001738)2.19572353
84Abnormality of liposaccharide metabolism (HP:0010968)2.18571050
85Abnormality of glycosphingolipid metabolism (HP:0004343)2.18571050
86Abnormality of glycolipid metabolism (HP:0010969)2.18571050
87Protuberant abdomen (HP:0001538)2.18172281
88Testicular atrophy (HP:0000029)2.17197913
89Congenital sensorineural hearing impairment (HP:0008527)2.16915826
90Abnormal tarsal ossification (HP:0008369)2.15655496
91Redundant skin (HP:0001582)2.14037328
92Septate vagina (HP:0001153)2.13823029
93Aplastic anemia (HP:0001915)2.13046667
94Severe short stature (HP:0003510)2.10800354
95Hand muscle atrophy (HP:0009130)2.10701692
96Hyperthyroidism (HP:0000836)2.10411656
97Abnormality of aromatic amino acid family metabolism (HP:0004338)2.07361434
98Abnormality of carpal bone ossification (HP:0006257)2.07050424
99Keratoconus (HP:0000563)2.07026096
100Increased corneal curvature (HP:0100692)2.07026096
101Abnormality of the vertebral endplates (HP:0005106)2.06678790
102Abnormality of the acetabulum (HP:0003170)2.06135499
103Platyspondyly (HP:0000926)2.04378760
104Flat acetabular roof (HP:0003180)2.04370867
105Bladder diverticulum (HP:0000015)2.03867249
106Abnormality of the common coagulation pathway (HP:0010990)2.03306385
107Aortic dissection (HP:0002647)2.02720213
108Patchy hypopigmentation of hair (HP:0011365)2.01488425
109Metaphyseal irregularity (HP:0003025)2.01301132
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.00897066
111Increased neuronal autofluorescent lipopigment (HP:0002074)2.00731022
112Papilledema (HP:0001085)2.00728182
113Vascular calcification (HP:0004934)1.96522680
114Ileus (HP:0002595)1.95698261
115Coxa valga (HP:0002673)1.93979360
116Broad face (HP:0000283)1.92799608
117Ovoid vertebral bodies (HP:0003300)1.92581878
118Wormian bones (HP:0002645)1.91041398
119Distal upper limb amyotrophy (HP:0007149)1.89194684
120Upper limb amyotrophy (HP:0009129)1.89194684
121Long toe (HP:0010511)1.88567761
122Natal tooth (HP:0000695)1.87814367
123Loss of speech (HP:0002371)1.86629181
124Hyperammonemia (HP:0001987)1.86425249
125Constricted visual fields (HP:0001133)1.86290359
126Conjugated hyperbilirubinemia (HP:0002908)1.85680288
127Glucose intolerance (HP:0000833)1.85323820
128Abnormality of the odontoid process (HP:0003310)1.84760166
129Petechiae (HP:0000967)1.83918950
130Proximal tubulopathy (HP:0000114)1.83773313
131Cortical visual impairment (HP:0100704)1.83695064
132Abnormality of the fovea (HP:0000493)1.82476991
133Abnormal mitochondria in muscle tissue (HP:0008316)1.82194179
134Limb hypertonia (HP:0002509)1.81916699
135Orthostatic hypotension (HP:0001278)1.81850572
136Hypoplasia of the fovea (HP:0007750)1.80380919
137Aplasia/Hypoplasia of the fovea (HP:0008060)1.80380919
13811 pairs of ribs (HP:0000878)1.79042097
139Vertebral compression fractures (HP:0002953)1.77926047
140Trismus (HP:0000211)1.77082229
141Congenital ichthyosiform erythroderma (HP:0007431)1.76761496
142White forelock (HP:0002211)1.76434919
143Esophageal varix (HP:0002040)1.76390942
144Osteoarthritis (HP:0002758)1.75674780
145Nonimmune hydrops fetalis (HP:0001790)1.75564914
146Genu recurvatum (HP:0002816)1.75468860
147Type II lissencephaly (HP:0007260)1.75294480
148Increased cerebral lipofuscin (HP:0011813)1.75182696
149Abnormality of the tricuspid valve (HP:0001702)1.74471027
150Abnormality of the Achilles tendon (HP:0005109)1.74252527
151Severe visual impairment (HP:0001141)1.73512688
152Abnormality of potassium homeostasis (HP:0011042)1.72870871
153Achilles tendon contracture (HP:0001771)1.72258856
154Flattened epiphyses (HP:0003071)1.72156732
155Prominent metopic ridge (HP:0005487)1.70017621
156Hepatic necrosis (HP:0002605)1.69995257
157Abnormal hair laboratory examination (HP:0003328)1.69531793
158Hypoplasia of the pons (HP:0012110)1.68805737
159Hypophosphatemia (HP:0002148)1.68777458
160Osteomalacia (HP:0002749)1.68411744
161Abnormal delivery (HP:0001787)1.68202000
162Cardiomegaly (HP:0001640)1.67765222
163Abnormality of T cell physiology (HP:0011840)1.66314131
164Unilateral renal agenesis (HP:0000122)1.66096446
165Hypotension (HP:0002615)1.65898765
166Episodic fever (HP:0001954)1.65645625
167Abnormality of renin-angiotensin system (HP:0000847)1.65301455
168Hyperactive renin-angiotensin system (HP:0000841)1.65070970
169Abnormality of the pons (HP:0007361)1.64916459
170Congenital glaucoma (HP:0001087)1.63360171
171Ketosis (HP:0001946)1.62851036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.90898036
2ERN14.55593307
3MAPK154.39355029
4TAOK33.83519356
5PASK3.50617874
6FRK3.42167808
7PIK3CG3.03048048
8EIF2AK32.66826668
9MAP3K22.49431784
10PKN22.49263876
11IRAK32.45191303
12BCKDK2.40054719
13WNK42.36654017
14PRKD32.33009275
15LIMK12.16953985
16FLT32.15165728
17WNK32.13612252
18HIPK22.00870009
19MAP3K122.00482296
20TESK21.88227849
21CAMKK21.84360805
22PAK41.76967707
23IRAK41.76121007
24STK161.70763944
25AKT31.67591079
26ILK1.66619747
27MAP3K31.62921501
28BRSK21.56334173
29TEC1.50461600
30VRK21.50183276
31SCYL21.49300336
32MST1R1.44978405
33MAPKAPK51.36176870
34TESK11.29988501
35ABL21.29844085
36LMTK21.29711398
37MUSK1.26431958
38KDR1.23273352
39PIM21.23059382
40NME21.16544491
41PBK1.15328873
42MAP3K111.14071005
43MAP2K21.12885634
44IRAK11.05756832
45DAPK11.05696502
46SMG11.04921473
47BTK1.00959225
48JAK31.00349024
49EEF2K0.98984944
50MAP3K10.95335087
51ZAP700.94819673
52EPHA30.92376442
53MYLK0.90431849
54NME10.90357378
55MAP2K10.89100481
56EIF2AK10.88866830
57ACVR1B0.87408673
58DAPK30.84696834
59MAPKAPK30.84618632
60ERBB30.84432679
61PTK60.84136711
62ADRBK10.82989686
63CDK70.82554609
64CSNK1G30.81972709
65NLK0.79221662
66UHMK10.78618919
67AURKA0.75664815
68ICK0.74928303
69MST40.74664751
70BMPR1B0.74380365
71MTOR0.74181226
72STK380.72488071
73IRAK20.70092144
74PRKG20.69863664
75ADRBK20.68441507
76MAP3K140.66897985
77LATS10.66762685
78BRAF0.66712684
79EPHB20.66023762
80RPS6KA20.65236322
81SIK10.65188731
82ITK0.63396763
83CSNK1A1L0.62044183
84CDK90.61298580
85PRKD20.59765019
86TRIB30.58816592
87CDK80.57457801
88CDC42BPA0.56946202
89TRPM70.56738051
90PDGFRA0.56570709
91PRKCI0.54423928
92LRRK20.54337776
93TLK10.53008435
94CAMK2G0.52752850
95AKT20.52507484
96MET0.51253727
97MAPK110.51021304
98MAP4K20.50627337
99JAK10.50152796
100JAK20.49904119
101DYRK1B0.49814952
102RPS6KA50.49565515
103IKBKB0.49460469
104RPS6KA40.48901606
105VRK10.48872565
106NTRK10.48139613
107PTK20.48031498
108PDPK10.47837286
109TBK10.47730450
110TGFBR20.47570282
111PAK20.46522008
112NEK90.46277110
113PRKCH0.45574302
114BMPR20.45566272
115CSNK1G10.45116327
116BRSK10.44695236
117CAMK2D0.43078206
118RPS6KB10.42395603
119NEK60.39958858
120PTK2B0.38295243
121CSNK1A10.37889459
122CHEK20.37772625
123TYK20.37519926
124PRKCE0.36757045
125RPS6KL10.36470200
126RPS6KC10.36470200
127PAK10.34296647
128SYK0.33808154
129DYRK30.33634240
130EPHA20.33224600
131RPS6KA60.33052612
132MAP2K30.32895562
133TGFBR10.32772838
134PDK20.32394544
135PAK30.30900621
136MAP2K60.30497707
137FER0.29662643
138MAPKAPK20.29586759
139IGF1R0.29145828
140WNK10.28961539
141CAMK1D0.28486122
142DDR20.28413461
143KIT0.25507301
144CSK0.25387796
145CHUK0.24335053
146LYN0.24124700
147MAPK30.22982390
148ZAK0.21018815
149RPS6KB20.20637016
150STK38L0.20136596
151ARAF0.18883472
152GSK3A0.18608477
153GRK10.17356895
154PRKCD0.17082240

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030607.80627992
2Maturity onset diabetes of the young_Homo sapiens_hsa049506.86743630
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.25613827
4Sulfur metabolism_Homo sapiens_hsa009203.55291217
5N-Glycan biosynthesis_Homo sapiens_hsa005103.25643025
6Other glycan degradation_Homo sapiens_hsa005112.85894934
7Vibrio cholerae infection_Homo sapiens_hsa051102.29741100
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.27092696
9Glutathione metabolism_Homo sapiens_hsa004802.20631283
10Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.15002773
11Lysosome_Homo sapiens_hsa041422.13502406
12Folate biosynthesis_Homo sapiens_hsa007901.93186166
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.91892918
14One carbon pool by folate_Homo sapiens_hsa006701.84003246
15Insulin secretion_Homo sapiens_hsa049111.79297413
16SNARE interactions in vesicular transport_Homo sapiens_hsa041301.72832314
17Fatty acid elongation_Homo sapiens_hsa000621.69293493
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.56356107
19Proteasome_Homo sapiens_hsa030501.56283174
20Pentose phosphate pathway_Homo sapiens_hsa000301.50204868
21Type I diabetes mellitus_Homo sapiens_hsa049401.47898724
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46510531
23Pancreatic secretion_Homo sapiens_hsa049721.42130484
24Protein digestion and absorption_Homo sapiens_hsa049741.40709321
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32284580
26Sphingolipid metabolism_Homo sapiens_hsa006001.23404618
27Galactose metabolism_Homo sapiens_hsa000521.21347691
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.21335222
29Selenocompound metabolism_Homo sapiens_hsa004501.21127920
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18796007
31Arginine biosynthesis_Homo sapiens_hsa002201.18695840
32Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.18229491
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.15904428
34Regulation of autophagy_Homo sapiens_hsa041401.12544109
35Antigen processing and presentation_Homo sapiens_hsa046121.09353599
36Base excision repair_Homo sapiens_hsa034101.08682693
37Renin-angiotensin system_Homo sapiens_hsa046141.08117597
38Biosynthesis of amino acids_Homo sapiens_hsa012301.08060126
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.07597280
40Thyroid hormone synthesis_Homo sapiens_hsa049181.01888897
41Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97479450
42Peroxisome_Homo sapiens_hsa041460.96247991
43Legionellosis_Homo sapiens_hsa051340.95940335
44Fatty acid biosynthesis_Homo sapiens_hsa000610.90301103
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.89626369
46Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82920195
47Huntingtons disease_Homo sapiens_hsa050160.81781695
48Arachidonic acid metabolism_Homo sapiens_hsa005900.81730239
49Phagosome_Homo sapiens_hsa041450.80651112
50Carbon metabolism_Homo sapiens_hsa012000.80273528
51RNA polymerase_Homo sapiens_hsa030200.79853851
52Fatty acid metabolism_Homo sapiens_hsa012120.79345012
53Type II diabetes mellitus_Homo sapiens_hsa049300.74988321
54Starch and sucrose metabolism_Homo sapiens_hsa005000.74704885
55Vitamin digestion and absorption_Homo sapiens_hsa049770.74109546
56Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.73984225
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72277824
58Butanoate metabolism_Homo sapiens_hsa006500.69886635
59Fat digestion and absorption_Homo sapiens_hsa049750.68496229
60Homologous recombination_Homo sapiens_hsa034400.67652780
61Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.67552221
62Synaptic vesicle cycle_Homo sapiens_hsa047210.67181937
63Primary bile acid biosynthesis_Homo sapiens_hsa001200.67114554
64Parkinsons disease_Homo sapiens_hsa050120.65767799
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64987577
66Tyrosine metabolism_Homo sapiens_hsa003500.64374020
67Linoleic acid metabolism_Homo sapiens_hsa005910.64009639
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63413183
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62697846
70Cocaine addiction_Homo sapiens_hsa050300.62243994
71Fructose and mannose metabolism_Homo sapiens_hsa000510.60964060
72Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58661606
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.58592812
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58474275
75Nucleotide excision repair_Homo sapiens_hsa034200.57994712
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57706433
77ABC transporters_Homo sapiens_hsa020100.57244627
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.56531717
79Steroid hormone biosynthesis_Homo sapiens_hsa001400.54459855
80Circadian rhythm_Homo sapiens_hsa047100.53067494
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48876172
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.48578991
83Insulin resistance_Homo sapiens_hsa049310.47291262
84Collecting duct acid secretion_Homo sapiens_hsa049660.45585444
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43201664
86Steroid biosynthesis_Homo sapiens_hsa001000.43188820
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40467998
88Prolactin signaling pathway_Homo sapiens_hsa049170.39406901
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.39079795
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.37995145
91DNA replication_Homo sapiens_hsa030300.37074393
92Oxidative phosphorylation_Homo sapiens_hsa001900.36712214
93Prion diseases_Homo sapiens_hsa050200.36048211
94Rheumatoid arthritis_Homo sapiens_hsa053230.35796781
95Nitrogen metabolism_Homo sapiens_hsa009100.35612047
96Phototransduction_Homo sapiens_hsa047440.35352030
97Thyroid cancer_Homo sapiens_hsa052160.35331892
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33851065
99Glucagon signaling pathway_Homo sapiens_hsa049220.33614421
100Pertussis_Homo sapiens_hsa051330.31433101
101Prostate cancer_Homo sapiens_hsa052150.31151164
102Small cell lung cancer_Homo sapiens_hsa052220.30830288
103Metabolic pathways_Homo sapiens_hsa011000.30800060
104Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30350602
105p53 signaling pathway_Homo sapiens_hsa041150.30149575
106Ether lipid metabolism_Homo sapiens_hsa005650.30119086
107Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29796922
108Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.29071295
109ECM-receptor interaction_Homo sapiens_hsa045120.29054767
110Bladder cancer_Homo sapiens_hsa052190.28503267
111Leishmaniasis_Homo sapiens_hsa051400.28417177
112Histidine metabolism_Homo sapiens_hsa003400.28406025
113Melanoma_Homo sapiens_hsa052180.27165936
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.25859513
115Sulfur relay system_Homo sapiens_hsa041220.25298727
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24259506
117Mineral absorption_Homo sapiens_hsa049780.24215882
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.22351346
119Pyrimidine metabolism_Homo sapiens_hsa002400.22297757
120Ribosome_Homo sapiens_hsa030100.21702044
121Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.20352035
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.19326052
123Non-homologous end-joining_Homo sapiens_hsa034500.18449115
124Tryptophan metabolism_Homo sapiens_hsa003800.18434738
125Alzheimers disease_Homo sapiens_hsa050100.17994779
126NF-kappa B signaling pathway_Homo sapiens_hsa040640.16943421
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15092256
128Arginine and proline metabolism_Homo sapiens_hsa003300.14754006
129Apoptosis_Homo sapiens_hsa042100.12842759
130Tuberculosis_Homo sapiens_hsa051520.12740916
131PI3K-Akt signaling pathway_Homo sapiens_hsa041510.12398962
132Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.10697905
133Purine metabolism_Homo sapiens_hsa002300.10492072
134Inositol phosphate metabolism_Homo sapiens_hsa005620.10439943
135Hepatitis C_Homo sapiens_hsa051600.10382318
136Hematopoietic cell lineage_Homo sapiens_hsa046400.10013602
137NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09914816
138Influenza A_Homo sapiens_hsa051640.09834878
139Amoebiasis_Homo sapiens_hsa051460.09091870
140RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08778211
141Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08384615
142TNF signaling pathway_Homo sapiens_hsa046680.08192703
143Focal adhesion_Homo sapiens_hsa045100.07631097
144Hepatitis B_Homo sapiens_hsa051610.07141649
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.06979367
146Toxoplasmosis_Homo sapiens_hsa051450.06505553
147Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.05870563
148Amphetamine addiction_Homo sapiens_hsa050310.05635556
149Measles_Homo sapiens_hsa051620.05165431
150Alcoholism_Homo sapiens_hsa050340.04819352
151Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.04528410

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