TMED4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.85101065
2Golgi transport vesicle coating (GO:0048200)6.85101065
3signal peptide processing (GO:0006465)5.04729703
4respiratory chain complex IV assembly (GO:0008535)4.71928008
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.50730337
6cytochrome complex assembly (GO:0017004)4.47654632
7peptide hormone processing (GO:0016486)4.25118772
8water-soluble vitamin biosynthetic process (GO:0042364)4.19554307
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.16328741
10L-phenylalanine catabolic process (GO:0006559)4.16328741
11retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.15233064
12protein retention in ER lumen (GO:0006621)4.09320853
13inositol phosphate catabolic process (GO:0071545)4.06160597
14endocrine pancreas development (GO:0031018)4.05354985
15protein maturation by protein folding (GO:0022417)4.05111368
16regulation of glucokinase activity (GO:0033131)3.97359896
17regulation of hexokinase activity (GO:1903299)3.97359896
18protein complex biogenesis (GO:0070271)3.97265273
19COPII vesicle coating (GO:0048208)3.95310689
20L-phenylalanine metabolic process (GO:0006558)3.84122911
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.84122911
22phosphorylated carbohydrate dephosphorylation (GO:0046838)3.76075830
23inositol phosphate dephosphorylation (GO:0046855)3.76075830
24ER overload response (GO:0006983)3.65072785
25positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.54554504
26mitochondrial respiratory chain complex assembly (GO:0033108)3.54228477
27regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.47605336
28platelet dense granule organization (GO:0060155)3.44712153
29glycerophospholipid catabolic process (GO:0046475)3.42749084
30NADH metabolic process (GO:0006734)3.41832656
31polyol catabolic process (GO:0046174)3.35795041
32exocrine pancreas development (GO:0031017)3.35171323
33keratinocyte development (GO:0003334)3.34468949
34preassembly of GPI anchor in ER membrane (GO:0016254)3.33971687
35DNA deamination (GO:0045006)3.31252578
36mannosylation (GO:0097502)3.29601661
37succinate metabolic process (GO:0006105)3.26845774
38C-terminal protein lipidation (GO:0006501)3.25533082
39glandular epithelial cell differentiation (GO:0002067)3.25378257
40sequestering of metal ion (GO:0051238)3.22935053
41tricarboxylic acid cycle (GO:0006099)3.21019533
42regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20312930
43positive regulation of glycoprotein biosynthetic process (GO:0010560)3.14815103
44xenobiotic catabolic process (GO:0042178)3.11278887
45toxin metabolic process (GO:0009404)3.09906946
46branched-chain amino acid catabolic process (GO:0009083)3.08885681
47negative regulation of execution phase of apoptosis (GO:1900118)3.03915929
48tricarboxylic acid metabolic process (GO:0072350)3.02093330
49regulation of oxidative phosphorylation (GO:0002082)3.01404236
50positive regulation of insulin secretion (GO:0032024)3.00594223
51glucosamine-containing compound catabolic process (GO:1901072)3.00338926
52ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.98304859
53C-terminal protein amino acid modification (GO:0018410)2.94411629
54peroxisome fission (GO:0016559)2.92758400
55S-adenosylmethionine metabolic process (GO:0046500)2.92406059
56nucleotide transmembrane transport (GO:1901679)2.91150395
57regulation of mitochondrial translation (GO:0070129)2.89996840
58negative regulation of neurological system process (GO:0031645)2.88746760
59peptide metabolic process (GO:0006518)2.88707299
60regulation of protein glycosylation (GO:0060049)2.88184594
61L-fucose metabolic process (GO:0042354)2.87954686
62L-fucose catabolic process (GO:0042355)2.87954686
63fucose catabolic process (GO:0019317)2.87954686
64positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.87403625
65zinc ion transport (GO:0006829)2.87147109
663-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.86866101
67purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.86866101
68branched-chain amino acid metabolic process (GO:0009081)2.86610076
69vesicle coating (GO:0006901)2.86405515
70mitochondrial respiratory chain complex I assembly (GO:0032981)2.84926136
71NADH dehydrogenase complex assembly (GO:0010257)2.84926136
72mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.84926136
73response to pheromone (GO:0019236)2.83802718
74prostate gland growth (GO:0060736)2.81554837
75oxaloacetate metabolic process (GO:0006107)2.81115875
76thyroid hormone metabolic process (GO:0042403)2.79337955
77regulation of neurotransmitter uptake (GO:0051580)2.77565077
78protein K6-linked ubiquitination (GO:0085020)2.77415795
79peptide catabolic process (GO:0043171)2.77403412
80fatty acid beta-oxidation (GO:0006635)2.76374391
81positive regulation of actin filament depolymerization (GO:0030836)2.74311773
82magnesium ion transport (GO:0015693)2.72680155
83auditory receptor cell differentiation (GO:0042491)2.72446677
84axoneme assembly (GO:0035082)2.71278538
85ER to Golgi vesicle-mediated transport (GO:0006888)2.70542104
86aromatic amino acid family catabolic process (GO:0009074)2.70356199
87dentate gyrus development (GO:0021542)2.69683454
88intestinal cholesterol absorption (GO:0030299)2.69509052
89insulin secretion (GO:0030073)2.68970113
90cellular ketone body metabolic process (GO:0046950)2.68796320
91positive regulation of glycolytic process (GO:0045821)2.68776798
92intra-Golgi vesicle-mediated transport (GO:0006891)2.68416372
93mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67884140
94ATP hydrolysis coupled proton transport (GO:0015991)2.67178936
95energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.67178936
96fatty acid catabolic process (GO:0009062)2.66578208
97kidney morphogenesis (GO:0060993)2.66237416
98regulation of insulin secretion (GO:0050796)2.66181259
99nitric oxide mediated signal transduction (GO:0007263)2.63135348
100positive regulation of protein autophosphorylation (GO:0031954)2.60496098
101activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.60259871
102alpha-linolenic acid metabolic process (GO:0036109)2.60101613
103positive regulation of glycoprotein metabolic process (GO:1903020)2.57934820
104lactate metabolic process (GO:0006089)2.57897033
105detection of calcium ion (GO:0005513)2.57435711
106epithelial cell fate commitment (GO:0072148)2.57359166
107negative regulation of protein oligomerization (GO:0032460)2.55800409
108regulation of cilium movement (GO:0003352)2.54909014
109regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.51187920
110fatty acid oxidation (GO:0019395)2.51070716
111lipid oxidation (GO:0034440)2.49443729
112nitric oxide biosynthetic process (GO:0006809)2.49135203
113protein N-linked glycosylation via asparagine (GO:0018279)2.48752887
114GDP-mannose metabolic process (GO:0019673)2.47553617
115peptidyl-asparagine modification (GO:0018196)2.47276635
116positive regulation of peptide hormone secretion (GO:0090277)2.46412750
117negative regulation of hormone biosynthetic process (GO:0032353)2.45522986
118short-chain fatty acid metabolic process (GO:0046459)2.45449768
119GPI anchor metabolic process (GO:0006505)2.45391271
120synapsis (GO:0007129)2.45390370
121regulation of peptide hormone secretion (GO:0090276)2.45189032
122tyrosine metabolic process (GO:0006570)2.44044590
123ribonucleoside bisphosphate metabolic process (GO:0033875)2.43649150
124nucleoside bisphosphate metabolic process (GO:0033865)2.43649150
125purine nucleoside bisphosphate metabolic process (GO:0034032)2.43649150
126glycoside metabolic process (GO:0016137)2.43001291
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.42783579
128neuron fate determination (GO:0048664)2.42034083
129lysine catabolic process (GO:0006554)2.41957147
130lysine metabolic process (GO:0006553)2.41957147
131monocarboxylic acid catabolic process (GO:0072329)2.41955236
132regulation of peptide secretion (GO:0002791)2.41032612
133positive regulation of nuclease activity (GO:0032075)2.41014378
134positive regulation of peptide secretion (GO:0002793)2.40658820
135positive regulation of meiosis (GO:0045836)2.40157348
136regulation of B cell apoptotic process (GO:0002902)2.39974560
137glyoxylate metabolic process (GO:0046487)2.39423044
138fatty acid elongation (GO:0030497)2.39277391
139negative regulation of cytosolic calcium ion concentration (GO:0051481)2.38105283
140positive regulation of TOR signaling (GO:0032008)2.37704416
141proteasome assembly (GO:0043248)2.35904142
142ketone body metabolic process (GO:1902224)2.35622600
143intestinal absorption (GO:0050892)2.34629716
144fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.34459446
145brain morphogenesis (GO:0048854)2.33519350
146coenzyme catabolic process (GO:0009109)2.33005586
147negative regulation of acute inflammatory response (GO:0002674)2.32827497
148peptidyl-histidine modification (GO:0018202)2.32796588
149endoplasmic reticulum unfolded protein response (GO:0030968)2.32704016
150protein localization to cilium (GO:0061512)2.32629672
151acyl-CoA biosynthetic process (GO:0071616)2.31415697
152thioester biosynthetic process (GO:0035384)2.31415697
153artery smooth muscle contraction (GO:0014824)2.31138682
154protein N-linked glycosylation (GO:0006487)2.31104985
155GPI anchor biosynthetic process (GO:0006506)2.30895760
156prenylation (GO:0097354)2.30878593
157respiratory electron transport chain (GO:0022904)2.30485952
158aldehyde catabolic process (GO:0046185)2.30036449
159cellular response to unfolded protein (GO:0034620)2.29728995
160regulation of penile erection (GO:0060405)2.29549071
161cell redox homeostasis (GO:0045454)2.29093640
162ER-nucleus signaling pathway (GO:0006984)2.28530456
163aspartate family amino acid catabolic process (GO:0009068)2.28412804
164electron transport chain (GO:0022900)2.28291749
165cellular response to topologically incorrect protein (GO:0035967)2.28221442
166transferrin transport (GO:0033572)2.28073337
167response to misfolded protein (GO:0051788)2.27987998
1682-oxoglutarate metabolic process (GO:0006103)2.27869552
1694-hydroxyproline metabolic process (GO:0019471)2.27784241
170peroxisome organization (GO:0007031)2.27432162

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.71658966
2PDX1_19855005_ChIP-ChIP_MIN6_Mouse3.40661724
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.15963515
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.96646231
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68270718
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.54573414
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.44153697
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.38570324
9ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31835044
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29971223
11* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.22747429
12VDR_22108803_ChIP-Seq_LS180_Human2.21866188
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.20134946
14* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.20052641
15TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.10298194
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.06238340
17FUS_26573619_Chip-Seq_HEK293_Human1.90634839
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.88167038
19DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.87429608
20GATA1_22025678_ChIP-Seq_K562_Human1.85741038
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.79353706
22GBX2_23144817_ChIP-Seq_PC3_Human1.73388936
23P300_19829295_ChIP-Seq_ESCs_Human1.70629579
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70056010
25PCGF2_27294783_Chip-Seq_ESCs_Mouse1.64952316
26AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.64664580
27EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.63108888
28ER_23166858_ChIP-Seq_MCF-7_Human1.59851217
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.57056776
30TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56077148
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.55665400
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.55066542
33TP53_22573176_ChIP-Seq_HFKS_Human1.54018438
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52941710
35ELK1_19687146_ChIP-ChIP_HELA_Human1.52634677
36EWS_26573619_Chip-Seq_HEK293_Human1.50694778
37FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48145197
38FOXA1_25329375_ChIP-Seq_VCAP_Human1.48145197
39SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45871951
40VDR_23849224_ChIP-Seq_CD4+_Human1.44945632
41NFE2_27457419_Chip-Seq_LIVER_Mouse1.40636099
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.40215571
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.39831287
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.39672708
45KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.37491185
46AR_25329375_ChIP-Seq_VCAP_Human1.37070892
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34560210
48HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34346586
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.31531328
50IGF1R_20145208_ChIP-Seq_DFB_Human1.31134087
51P53_22387025_ChIP-Seq_ESCs_Mouse1.30970698
52SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.29613052
53* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.29487515
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28832976
55NANOG_18555785_Chip-Seq_ESCs_Mouse1.28547397
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27401589
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.27401589
58CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.27396108
59EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.26196539
60HTT_18923047_ChIP-ChIP_STHdh_Human1.24579837
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.24319233
62CRX_20693478_ChIP-Seq_RETINA_Mouse1.24093768
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24061618
64* REST_18959480_ChIP-ChIP_MESCs_Mouse1.23607661
65MYC_18940864_ChIP-ChIP_HL60_Human1.23356712
66FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23318894
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.22913007
68CDX2_22108803_ChIP-Seq_LS180_Human1.22617621
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21416492
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21230205
71CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.20641715
72SOX2_20726797_ChIP-Seq_SW620_Human1.19787206
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19606970
74CBP_20019798_ChIP-Seq_JUKART_Human1.19606970
75FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.17758980
76SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17245484
77* STAT3_23295773_ChIP-Seq_U87_Human1.16919983
78SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.16456655
79SOX2_18555785_Chip-Seq_ESCs_Mouse1.16383878
80TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16220705
81SMAD3_21741376_ChIP-Seq_EPCs_Human1.15750915
82CTBP2_25329375_ChIP-Seq_LNCAP_Human1.15658755
83SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.15443734
84BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15385911
85REST_21632747_ChIP-Seq_MESCs_Mouse1.15346779
86* TCF4_22108803_ChIP-Seq_LS180_Human1.14891458
87SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14323632
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13093914
89UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13042279
90* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12245318
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.12059993
92NCOR_22424771_ChIP-Seq_293T_Human1.11328967
93CMYC_18555785_Chip-Seq_ESCs_Mouse1.11249938
94SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11113845
95EP300_21415370_ChIP-Seq_HL-1_Mouse1.10972255
96CLOCK_20551151_ChIP-Seq_293T_Human1.10791450
97TCF4_23295773_ChIP-Seq_U87_Human1.10682832
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09775932
99SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09767239
100AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.09300221
101SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.09238484
102NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09064291
103P300_18555785_Chip-Seq_ESCs_Mouse1.08778405
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08146486
105ERG_20517297_ChIP-Seq_VCAP_Human1.07310249
106E2F1_18555785_Chip-Seq_ESCs_Mouse1.07103752
107PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06941407
108NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.06752428
109TAF15_26573619_Chip-Seq_HEK293_Human1.06314503
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05566333
111POU3F2_20337985_ChIP-ChIP_501MEL_Human1.05512008
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05296479
113PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05256269
114ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.04858370
115OCT4_18555785_Chip-Seq_ESCs_Mouse1.04389812
116ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04022585
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.03471921
118CTCF_18555785_Chip-Seq_ESCs_Mouse1.03155070
119HOXB7_26014856_ChIP-Seq_BT474_Human1.03099692
120ZFX_18555785_Chip-Seq_ESCs_Mouse1.02841682
121* GATA3_21878914_ChIP-Seq_MCF-7_Human1.02805177
122LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02117103
123ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01644268
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01552313
125FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01324124
126KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01195422
127CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00615812
128PHF8_20622853_ChIP-Seq_HELA_Human1.00051485
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.99562827
130OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99140399
131ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98690226
132EZH2_27294783_Chip-Seq_ESCs_Mouse0.98488643
133ZNF274_21170338_ChIP-Seq_K562_Hela0.98127714
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96770099
135* AR_20517297_ChIP-Seq_VCAP_Human0.96579149
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.92658850
137FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92590614
138EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91474763
139PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.91252140
140* JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89870337
141TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.87694252
142ESR1_21235772_ChIP-Seq_MCF-7_Human0.87316670
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87292876
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86115768
145* REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84896088
146FOXA1_25552417_ChIP-Seq_VCAP_Human0.84721196
147STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.84236266
148RARG_19884340_ChIP-ChIP_MEFs_Mouse0.84173719
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83885404
150ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.83408976
151GABP_17652178_ChIP-ChIP_JURKAT_Human0.83173235
152BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82908857
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.82645405
154MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.81345519
155JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81279150
156FOXH1_21741376_ChIP-Seq_ESCs_Human0.80719389
157SOX2_19829295_ChIP-Seq_ESCs_Human0.80525813
158NANOG_19829295_ChIP-Seq_ESCs_Human0.80525813
159FOXA2_19822575_ChIP-Seq_HepG2_Human0.79745440
160CDX2_19796622_ChIP-Seq_MESCs_Mouse0.79442928
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.78905151
162SUZ12_27294783_Chip-Seq_ESCs_Mouse0.78679444
163OCT4_20526341_ChIP-Seq_ESCs_Human0.78073961
164SMAD4_21799915_ChIP-Seq_A2780_Human0.75793353
165BCAT_22108803_ChIP-Seq_LS180_Human0.74418222
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73957160
167PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72642121

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.17437413
2MP0003183_abnormal_peptide_metabolism3.72919727
3MP0003195_calcinosis3.71280622
4MP0002139_abnormal_hepatobiliary_system3.58216600
5MP0002837_dystrophic_cardiac_calcinosis3.31692328
6MP0010234_abnormal_vibrissa_follicle3.22071633
7MP0009780_abnormal_chondrocyte_physiolo3.01751014
8MP0000013_abnormal_adipose_tissue2.92129061
9MP0005365_abnormal_bile_salt2.74758857
10MP0005360_urolithiasis2.63769809
11MP0002163_abnormal_gland_morphology2.55089040
12MP0000372_irregular_coat_pigmentation2.48408178
13MP0003787_abnormal_imprinting2.45169400
14MP0002909_abnormal_adrenal_gland2.41605268
15MP0010386_abnormal_urinary_bladder2.38938325
16MP0002876_abnormal_thyroid_physiology2.28723446
17MP0005367_renal/urinary_system_phenotyp2.28119834
18MP0000516_abnormal_urinary_system2.28119834
19MP0001944_abnormal_pancreas_morphology2.25281258
20MP0002693_abnormal_pancreas_physiology2.24110555
21MP0008875_abnormal_xenobiotic_pharmacok2.23260490
22MP0005220_abnormal_exocrine_pancreas2.17104278
23MP0005085_abnormal_gallbladder_physiolo2.14507320
24MP0001666_abnormal_nutrient_absorption2.12086183
25MP0003283_abnormal_digestive_organ2.09173168
26MP0008877_abnormal_DNA_methylation2.01680663
27MP0002877_abnormal_melanocyte_morpholog2.01135312
28MP0002102_abnormal_ear_morphology1.95475926
29MP0002938_white_spotting1.95125145
30MP0005058_abnormal_lysosome_morphology1.92279942
31MP0005379_endocrine/exocrine_gland_phen1.89109501
32MP0002078_abnormal_glucose_homeostasis1.88871508
33MP0001984_abnormal_olfaction1.81772259
34MP0005332_abnormal_amino_acid1.77803635
35MP0005646_abnormal_pituitary_gland1.76092661
36MP0009643_abnormal_urine_homeostasis1.74412199
37MP0001986_abnormal_taste_sensitivity1.72235287
38MP0005075_abnormal_melanosome_morpholog1.70496834
39MP0005645_abnormal_hypothalamus_physiol1.65513099
40MP0005408_hypopigmentation1.64440535
41MP0005083_abnormal_biliary_tract1.64129775
42MP0003252_abnormal_bile_duct1.64120981
43MP0001765_abnormal_ion_homeostasis1.63682770
44MP0009046_muscle_twitch1.60805195
45MP0000678_abnormal_parathyroid_gland1.60633719
46MP0006054_spinal_hemorrhage1.59007628
47MP0005084_abnormal_gallbladder_morpholo1.53692289
48MP0005174_abnormal_tail_pigmentation1.53440057
49MP0005636_abnormal_mineral_homeostasis1.50768672
50MP0001756_abnormal_urination1.49977802
51MP0009840_abnormal_foam_cell1.48681037
52MP0000427_abnormal_hair_cycle1.46549726
53MP0006036_abnormal_mitochondrial_physio1.45760440
54MP0000003_abnormal_adipose_tissue1.45717925
55MP0010329_abnormal_lipoprotein_level1.45385244
56MP0003868_abnormal_feces_composition1.39761695
57MP0002118_abnormal_lipid_homeostasis1.36548222
58MP0003806_abnormal_nucleotide_metabolis1.35406559
59MP0008872_abnormal_physiological_respon1.32327236
60MP0003122_maternal_imprinting1.31024383
61MP0003011_delayed_dark_adaptation1.28293010
62MP0003879_abnormal_hair_cell1.28220580
63MP0003786_premature_aging1.27601587
64MP0005535_abnormal_body_temperature1.26680402
65MP0003953_abnormal_hormone_level1.23675237
66MP0000230_abnormal_systemic_arterial1.23496147
67MP0000462_abnormal_digestive_system1.22645917
68MP0010678_abnormal_skin_adnexa1.21825396
69MP0001764_abnormal_homeostasis1.21776113
70MP0002138_abnormal_hepatobiliary_system1.21725231
71MP0006072_abnormal_retinal_apoptosis1.19784826
72MP0000015_abnormal_ear_pigmentation1.19644280
73MP0001502_abnormal_circadian_rhythm1.18455667
74MP0001485_abnormal_pinna_reflex1.17743019
75MP0001664_abnormal_digestion1.17448144
76MP0002160_abnormal_reproductive_system1.17022347
77MP0004264_abnormal_extraembryonic_tissu1.14102764
78MP0004270_analgesia1.13794859
79MP0003172_abnormal_lysosome_physiology1.10955694
80MP0004036_abnormal_muscle_relaxation1.08890512
81MP0000566_synostosis1.08150767
82MP0000569_abnormal_digit_pigmentation1.07101284
83MP0005389_reproductive_system_phenotype1.05760913
84MP0003959_abnormal_lean_body1.04302575
85MP0004133_heterotaxia1.03974086
86MP0001270_distended_abdomen1.03583733
87MP0001905_abnormal_dopamine_level1.02858571
88MP0001501_abnormal_sleep_pattern1.00445472
89MP0003121_genomic_imprinting0.98999392
90MP0002254_reproductive_system_inflammat0.98760465
91MP0008775_abnormal_heart_ventricle0.98464438
92MP0008995_early_reproductive_senescence0.98046631
93MP0003329_amyloid_beta_deposits0.97432170
94MP0000538_abnormal_urinary_bladder0.96195650
95MP0009745_abnormal_behavioral_response0.95907601
96MP0002166_altered_tumor_susceptibility0.95663006
97MP0005448_abnormal_energy_balance0.95582035
98MP0001529_abnormal_vocalization0.94380474
99MP0002653_abnormal_ependyma_morphology0.91255991
100MP0000639_abnormal_adrenal_gland0.91024133
101MP0002557_abnormal_social/conspecific_i0.89966665
102MP0004019_abnormal_vitamin_homeostasis0.88939564
103MP0002638_abnormal_pupillary_reflex0.87982490
104MP0003191_abnormal_cellular_cholesterol0.87328466
105MP0005584_abnormal_enzyme/coenzyme_acti0.86492793
106MP0003186_abnormal_redox_activity0.86299688
107MP0003718_maternal_effect0.85790465
108MP0000681_abnormal_thyroid_gland0.84623634
109MP0004147_increased_porphyrin_level0.83719614
110MP0005670_abnormal_white_adipose0.83112033
111MP0002272_abnormal_nervous_system0.82717499
112MP0001661_extended_life_span0.82555563
113MP0004885_abnormal_endolymph0.81995553
114MP0004145_abnormal_muscle_electrophysio0.81233415
115MP0002928_abnormal_bile_duct0.80043079
116MP0002896_abnormal_bone_mineralization0.80030738
117MP0002734_abnormal_mechanical_nocicepti0.79971775
118MP0005319_abnormal_enzyme/_coenzyme0.79622831
119MP0002751_abnormal_autonomic_nervous0.79485836
120MP0002229_neurodegeneration0.79372830
121MP0002822_catalepsy0.78287419
122MP0008004_abnormal_stomach_pH0.77077506
123MP0003634_abnormal_glial_cell0.76794852
124MP0009642_abnormal_blood_homeostasis0.76458079
125MP0000749_muscle_degeneration0.76034796
126MP0004084_abnormal_cardiac_muscle0.75095759
127MP0000647_abnormal_sebaceous_gland0.75043677
128MP0000631_abnormal_neuroendocrine_gland0.74480861
129MP0002069_abnormal_eating/drinking_beha0.73773919
130MP0004130_abnormal_muscle_cell0.73476829
131MP0001968_abnormal_touch/_nociception0.71523247
132MP0002090_abnormal_vision0.71513295
133MP0002064_seizures0.69942693
134MP0002095_abnormal_skin_pigmentation0.69658336
135MP0003123_paternal_imprinting0.69417737
136MP0002234_abnormal_pharynx_morphology0.69132931
137MP0000613_abnormal_salivary_gland0.68832258
138MP0005551_abnormal_eye_electrophysiolog0.68087132
139MP0000920_abnormal_myelination0.66781432
140MP0004215_abnormal_myocardial_fiber0.66228635
141MP0000609_abnormal_liver_physiology0.65367018
142MP0004233_abnormal_muscle_weight0.64677386
143MP0005253_abnormal_eye_physiology0.64083613

Predicted human phenotypes

RankGene SetZ-score
1Hypoglycemic coma (HP:0001325)5.05403936
2Hyperinsulinemic hypoglycemia (HP:0000825)4.94815884
3Hypoglycemic seizures (HP:0002173)4.71614093
4Ketoacidosis (HP:0001993)4.58702700
5Symptomatic seizures (HP:0011145)4.37273439
6Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98742989
7Generalized aminoaciduria (HP:0002909)3.88547735
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.85898291
9Pheochromocytoma (HP:0002666)3.65864433
10Ketosis (HP:0001946)3.53858915
11Neuroendocrine neoplasm (HP:0100634)3.48751229
12Hyperglycemia (HP:0003074)3.43210572
13Late onset (HP:0003584)3.32702372
14Gout (HP:0001997)3.30205720
15Hepatic necrosis (HP:0002605)3.27559698
16Abnormality of vitamin B metabolism (HP:0004340)3.21802647
17Methylmalonic acidemia (HP:0002912)3.10058012
18Abnormal mitochondria in muscle tissue (HP:0008316)3.05870349
19Pancreatic islet-cell hyperplasia (HP:0004510)3.01970264
20Abnormality of endocrine pancreas physiology (HP:0012093)2.97826932
21Abnormality of the pancreatic islet cells (HP:0006476)2.97826932
22Pancreatic cysts (HP:0001737)2.92837557
23Acute necrotizing encephalopathy (HP:0006965)2.90933150
24Acute encephalopathy (HP:0006846)2.88320166
25Insulin-resistant diabetes mellitus (HP:0000831)2.87485861
26Pancreatic fibrosis (HP:0100732)2.84808861
27Dysostosis multiplex (HP:0000943)2.84726455
28Abnormality of calcium-phosphate metabolism (HP:0100530)2.82875684
29Intestinal atresia (HP:0011100)2.81085835
30Hamartoma of the eye (HP:0010568)2.80977910
31Tongue fasciculations (HP:0001308)2.78861764
32Large for gestational age (HP:0001520)2.77152718
33Hepatocellular necrosis (HP:0001404)2.74776835
34Hypothermia (HP:0002045)2.73600478
35Urinary glycosaminoglycan excretion (HP:0003541)2.70028933
36Mucopolysacchariduria (HP:0008155)2.70028933
37Abnormality of fatty-acid metabolism (HP:0004359)2.69745516
38Abnormality of the intrinsic pathway (HP:0010989)2.69026529
39Hemiparesis (HP:0001269)2.68991129
40Vacuolated lymphocytes (HP:0001922)2.67363585
41Decreased circulating renin level (HP:0003351)2.65823385
42Neoplasm of the adrenal cortex (HP:0100641)2.63851061
43Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.62818927
44Abnormality of midbrain morphology (HP:0002418)2.60664609
45Molar tooth sign on MRI (HP:0002419)2.60664609
46Hypokalemia (HP:0002900)2.55807082
47Abnormality of the renal cortex (HP:0011035)2.55560778
48Conjunctival hamartoma (HP:0100780)2.50957057
49Mitochondrial inheritance (HP:0001427)2.48140479
50Aplasia/Hypoplasia of the fovea (HP:0008060)2.48105858
51Hypoplasia of the fovea (HP:0007750)2.48105858
52Conjugated hyperbilirubinemia (HP:0002908)2.47805658
53Congenital stationary night blindness (HP:0007642)2.45113006
54Glycosuria (HP:0003076)2.45059299
55Abnormality of urine glucose concentration (HP:0011016)2.45059299
56True hermaphroditism (HP:0010459)2.44677523
57Nephronophthisis (HP:0000090)2.42382082
583-Methylglutaconic aciduria (HP:0003535)2.41885525
59Hyperactive renin-angiotensin system (HP:0000841)2.41635302
60Thyroiditis (HP:0100646)2.41309820
61Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40573190
62Abnormality of polysaccharide metabolism (HP:0011012)2.40573190
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40573190
64Opisthotonus (HP:0002179)2.39510827
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.38904333
66Dicarboxylic aciduria (HP:0003215)2.38904333
67Abnormality of vitamin metabolism (HP:0100508)2.38368090
68Renal cortical cysts (HP:0000803)2.37438720
69Congenital sensorineural hearing impairment (HP:0008527)2.36600998
70Double outlet right ventricle (HP:0001719)2.36472951
71Congenital malformation of the right heart (HP:0011723)2.36472951
72Abnormality of renin-angiotensin system (HP:0000847)2.34372576
73Disproportionate short-trunk short stature (HP:0003521)2.34145564
74Progressive neurologic deterioration (HP:0002344)2.32475537
75Progressive macrocephaly (HP:0004481)2.31204632
76Palpitations (HP:0001962)2.29691825
77Myoglobinuria (HP:0002913)2.24267553
78Abnormality of purine metabolism (HP:0004352)2.24252498
79Methylmalonic aciduria (HP:0012120)2.22945577
80Hypokalemic alkalosis (HP:0001949)2.22333818
81Cerebral edema (HP:0002181)2.20622258
82Abnormality of the vitamin B12 metabolism (HP:0004341)2.20594689
83Lipid accumulation in hepatocytes (HP:0006561)2.20340504
84Increased circulating renin level (HP:0000848)2.18559447
85Muscle fibrillation (HP:0010546)2.17871637
86Furrowed tongue (HP:0000221)2.16326127
87Increased CSF lactate (HP:0002490)2.15147529
88Abnormal pancreas size (HP:0012094)2.13755023
89Retinal atrophy (HP:0001105)2.13201499
90Enlarged penis (HP:0000040)2.12588859
91Increased hepatocellular lipid droplets (HP:0006565)2.11466534
92Oligomenorrhea (HP:0000876)2.07072081
93Agitation (HP:0000713)2.06856636
94Abnormal albumin level (HP:0012116)2.06246370
95Hypoalbuminemia (HP:0003073)2.06246370
96Proximal tubulopathy (HP:0000114)2.06237080
97Polydipsia (HP:0001959)2.05639219
98Abnormal drinking behavior (HP:0030082)2.05639219
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.03477010
100Decreased activity of mitochondrial respiratory chain (HP:0008972)2.03477010
101EEG with generalized epileptiform discharges (HP:0011198)2.03428874
102Hypsarrhythmia (HP:0002521)2.02675644
103Vascular calcification (HP:0004934)2.01335727
104Abnormality of the fovea (HP:0000493)2.01012398
105Hyperglycinuria (HP:0003108)2.00916665
106Abnormality of the renal medulla (HP:0100957)1.99907772
107Lethargy (HP:0001254)1.98324832
108Epileptiform EEG discharges (HP:0011182)1.97884850
109Albinism (HP:0001022)1.97087577
110Severe muscular hypotonia (HP:0006829)1.96713416
111Cutaneous melanoma (HP:0012056)1.94248414
112Type II lissencephaly (HP:0007260)1.94198289
113Hyperphosphaturia (HP:0003109)1.94181107
114Hyperthyroidism (HP:0000836)1.93643893
115Metabolic acidosis (HP:0001942)1.93379245
116Alkalosis (HP:0001948)1.92755558
117Hyperparathyroidism (HP:0000843)1.91487817
118Hypokinesia (HP:0002375)1.91445890
119Renal Fanconi syndrome (HP:0001994)1.90262026
120Hematochezia (HP:0002573)1.90219356
121Abnormality of chloride homeostasis (HP:0011422)1.90078737
122Insulin resistance (HP:0000855)1.89738310
123Protuberant abdomen (HP:0001538)1.89431134
124Lactic acidosis (HP:0003128)1.89286544
125Abnormality of potassium homeostasis (HP:0011042)1.88318064
126Growth hormone excess (HP:0000845)1.88156822
127Aplasia/hypoplasia of the uterus (HP:0008684)1.88131320
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.87439531
129Abnormal protein N-linked glycosylation (HP:0012347)1.87439531
130Abnormal protein glycosylation (HP:0012346)1.87439531
131Abnormal glycosylation (HP:0012345)1.87439531
132Abnormality of magnesium homeostasis (HP:0004921)1.87086869
133Abnormal rod and cone electroretinograms (HP:0008323)1.86773680
134Tubular atrophy (HP:0000092)1.85961575
135Abnormality of serine family amino acid metabolism (HP:0010894)1.85935074
136Abnormality of glycine metabolism (HP:0010895)1.85935074
137Metaphyseal dysplasia (HP:0100255)1.85933921
138Intrahepatic cholestasis (HP:0001406)1.85920397
139Urethral obstruction (HP:0000796)1.85784035
140Aqueductal stenosis (HP:0002410)1.85242395
141Tachypnea (HP:0002789)1.84813520
142Neoplasm of the adrenal gland (HP:0100631)1.83572919
143Hypomagnesemia (HP:0002917)1.81886043
144Hyperaldosteronism (HP:0000859)1.81621176
145Increased CSF protein (HP:0002922)1.81597630
146Widely patent fontanelles and sutures (HP:0004492)1.81303916
147Increased purine levels (HP:0004368)1.81144963
148Hyperuricemia (HP:0002149)1.81144963
149Attenuation of retinal blood vessels (HP:0007843)1.80466465
150Vomiting (HP:0002013)1.79742015
151Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79483170
152Abnormality of the common coagulation pathway (HP:0010990)1.78853197
153Congenital primary aphakia (HP:0007707)1.77782149
154Type I transferrin isoform profile (HP:0003642)1.76749056
155Increased muscle lipid content (HP:0009058)1.75655283
156Hyperventilation (HP:0002883)1.75342830
157Abdominal distention (HP:0003270)1.75250205
158Abolished electroretinogram (ERG) (HP:0000550)1.74885787
159Medial flaring of the eyebrow (HP:0010747)1.73155351
160Respiratory failure (HP:0002878)1.73089312

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.48936600
2BCKDK4.18130095
3MAPK153.54185796
4FGFR23.04531783
5MST43.00805899
6WNK42.96244176
7PASK2.94131506
8MAP4K22.82643964
9GRK12.67328196
10TAOK32.41269434
11WNK32.34688510
12PRKD32.29721533
13TRIM282.20372665
14CAMKK22.05415037
15ACVR1B1.92884149
16PIK3CG1.89707347
17ERN11.88343303
18FRK1.88096115
19NME11.76167475
20NUAK11.74207496
21ZAK1.72222502
22STK161.71845755
23MAP3K21.70491859
24OXSR11.66905464
25PLK21.66802576
26CASK1.66132278
27AKT31.62675434
28MYLK1.60073859
29HIPK21.57134527
30FLT31.52271619
31MAP3K41.49019122
32CSNK1G11.48111300
33EPHA31.47199957
34BMPR1B1.41836093
35IRAK11.40815701
36STK391.28888915
37LMTK21.28161360
38MKNK21.26742990
39ARAF1.25764090
40EIF2AK11.25075036
41SIK11.23097346
42BCR1.19859041
43SGK4941.19727403
44SGK2231.19727403
45TLK11.18948674
46CSNK1G21.18032559
47DAPK21.17819464
48MAP3K121.14715192
49STK241.13870694
50PDK31.12095903
51PDK41.12095903
52MET1.10088316
53UHMK11.07768176
54CDK191.06975550
55TESK11.05455296
56IRAK31.04862282
57PAK31.04840644
58NTRK11.04726459
59MAPKAPK31.04136995
60EPHB11.02115941
61MAP2K61.01882822
62PLK31.00921670
63LIMK10.99431456
64CSNK1A1L0.96530659
65VRK20.95919045
66STK30.95436135
67PRKCE0.94825805
68SIK30.94145934
69CAMK2D0.93563296
70PTK2B0.91660237
71NLK0.91125161
72MAP3K10.90670404
73MAPK130.88152464
74FGFR30.87803017
75MAP2K20.87660443
76PTK20.87504214
77PHKG20.84140506
78PHKG10.84140506
79CCNB10.82585561
80SGK20.81077828
81IRAK20.80484694
82TRPM70.80433469
83TNIK0.79410263
84FGFR40.78774600
85PDK20.78293042
86CAMK2B0.77998441
87MUSK0.77944913
88FER0.77280926
89CAMK2G0.77059221
90STK38L0.76925697
91BRAF0.74664465
92TIE10.73934650
93NEK60.72712203
94VRK10.70568658
95PRKCH0.70254370
96BRSK20.69748557
97PINK10.68948185
98SCYL20.64434272
99PTK60.63702191
100NTRK30.62697730
101ADRBK20.62453627
102DYRK1B0.58691802
103MAP2K70.57469290
104CDK80.55196816
105MAP2K10.54856672
106DAPK10.49909871
107PIK3CA0.49662198
108GRK50.49292016
109EIF2AK30.49029671
110TNK20.47489905
111PRKAA20.47288781
112MKNK10.46942318
113RPS6KA20.45702007
114WNK10.45589029
115CDC42BPA0.43596999
116IRAK40.43319825
117CAMK2A0.41122195
118IKBKB0.40455952
119PRKCG0.40007324
120ERBB40.38681507
121ADRBK10.38647975
122OBSCN0.38448868
123BMPR20.38299431
124GRK70.37910568
125PRKACA0.37207149
126PIM20.36905294
127MST1R0.36807520
128CSNK1G30.36556142
129TSSK60.36526036
130RPS6KA50.35816426
131STK110.35027466
132MAPKAPK50.33665765
133PRKACG0.33039175
134CSNK1D0.32750024
135GSK3A0.32612473
136STK40.32460892
137CSNK1A10.32171570
138TXK0.30786481
139PRKAA10.30747581
140PRKCQ0.30555801
141PRKCI0.29565534
142ERBB30.28972134
143TEC0.28118124
144PRKCA0.27487868
145ROCK10.26775495
146ABL10.26269200
147ILK0.22620248
148ATM0.22028088
149PRKACB0.21209014

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049505.21016784
2Protein export_Homo sapiens_hsa030604.25718521
3Sulfur metabolism_Homo sapiens_hsa009203.31083246
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.04797347
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.28949517
6Butanoate metabolism_Homo sapiens_hsa006502.20661520
7Vibrio cholerae infection_Homo sapiens_hsa051102.12951723
8Fatty acid elongation_Homo sapiens_hsa000622.10072250
9Oxidative phosphorylation_Homo sapiens_hsa001902.04707239
10Collecting duct acid secretion_Homo sapiens_hsa049661.94299232
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.86907640
12Vitamin B6 metabolism_Homo sapiens_hsa007501.86359461
13Propanoate metabolism_Homo sapiens_hsa006401.85143531
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.83947560
15Fatty acid degradation_Homo sapiens_hsa000711.82309637
16Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.80295137
17Proteasome_Homo sapiens_hsa030501.68784993
18Pyruvate metabolism_Homo sapiens_hsa006201.64560421
19Insulin secretion_Homo sapiens_hsa049111.62901942
20Tryptophan metabolism_Homo sapiens_hsa003801.62124731
21Nitrogen metabolism_Homo sapiens_hsa009101.52615065
22Fatty acid metabolism_Homo sapiens_hsa012121.52585975
23Peroxisome_Homo sapiens_hsa041461.49595632
24Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48582246
25Phototransduction_Homo sapiens_hsa047441.47371543
26Folate biosynthesis_Homo sapiens_hsa007901.47140057
27Parkinsons disease_Homo sapiens_hsa050121.45934519
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42406700
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38205196
30Lysosome_Homo sapiens_hsa041421.32774898
31Other glycan degradation_Homo sapiens_hsa005111.29841329
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.29213163
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.21249570
34N-Glycan biosynthesis_Homo sapiens_hsa005101.21097383
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15747572
36Alzheimers disease_Homo sapiens_hsa050101.14714030
37Histidine metabolism_Homo sapiens_hsa003401.14678922
38Starch and sucrose metabolism_Homo sapiens_hsa005001.12221399
39Mineral absorption_Homo sapiens_hsa049781.11543822
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09551637
41Carbon metabolism_Homo sapiens_hsa012001.07442252
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.06212651
43Fat digestion and absorption_Homo sapiens_hsa049751.05229661
44Synaptic vesicle cycle_Homo sapiens_hsa047211.05037792
45Phenylalanine metabolism_Homo sapiens_hsa003601.03358429
46Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02973075
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02757119
48Galactose metabolism_Homo sapiens_hsa000521.02175432
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99455372
50Glycosaminoglycan degradation_Homo sapiens_hsa005310.98295043
51Selenocompound metabolism_Homo sapiens_hsa004500.97954312
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.96552868
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94945956
54SNARE interactions in vesicular transport_Homo sapiens_hsa041300.94365333
55Tyrosine metabolism_Homo sapiens_hsa003500.94128983
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93494084
57Regulation of autophagy_Homo sapiens_hsa041400.93089085
58Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92843703
59Caffeine metabolism_Homo sapiens_hsa002320.90961888
60RNA polymerase_Homo sapiens_hsa030200.88874806
61Type I diabetes mellitus_Homo sapiens_hsa049400.83483281
62Fructose and mannose metabolism_Homo sapiens_hsa000510.83198683
63Homologous recombination_Homo sapiens_hsa034400.83049071
64beta-Alanine metabolism_Homo sapiens_hsa004100.82552515
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.82533540
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81906560
67Fanconi anemia pathway_Homo sapiens_hsa034600.79212460
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.79101018
69Steroid biosynthesis_Homo sapiens_hsa001000.77081192
70Arginine and proline metabolism_Homo sapiens_hsa003300.75813545
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.75659352
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.74150297
73Retinol metabolism_Homo sapiens_hsa008300.73267341
74Huntingtons disease_Homo sapiens_hsa050160.73179750
75Type II diabetes mellitus_Homo sapiens_hsa049300.72895642
76RNA degradation_Homo sapiens_hsa030180.70967641
77PPAR signaling pathway_Homo sapiens_hsa033200.69492268
78Basal transcription factors_Homo sapiens_hsa030220.69207553
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.68731935
80ABC transporters_Homo sapiens_hsa020100.68202456
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.68118304
82Arachidonic acid metabolism_Homo sapiens_hsa005900.66340005
83One carbon pool by folate_Homo sapiens_hsa006700.65088353
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.65034959
85Thyroid hormone synthesis_Homo sapiens_hsa049180.64436728
86Metabolic pathways_Homo sapiens_hsa011000.64316051
87Cocaine addiction_Homo sapiens_hsa050300.64203134
88Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62634447
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61390842
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60386102
91Vitamin digestion and absorption_Homo sapiens_hsa049770.59541869
92Pancreatic secretion_Homo sapiens_hsa049720.59271880
93Glucagon signaling pathway_Homo sapiens_hsa049220.59046521
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58460192
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57371942
96Purine metabolism_Homo sapiens_hsa002300.56881287
97Glutathione metabolism_Homo sapiens_hsa004800.54560636
98Biosynthesis of amino acids_Homo sapiens_hsa012300.54160303
99Chemical carcinogenesis_Homo sapiens_hsa052040.54072751
100Bile secretion_Homo sapiens_hsa049760.54022317
101GABAergic synapse_Homo sapiens_hsa047270.53345305
102Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53228430
103Renin-angiotensin system_Homo sapiens_hsa046140.53111058
104Circadian rhythm_Homo sapiens_hsa047100.52787725
105Arginine biosynthesis_Homo sapiens_hsa002200.51269165
106Ovarian steroidogenesis_Homo sapiens_hsa049130.50277227
107Sphingolipid metabolism_Homo sapiens_hsa006000.49267824
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48822084
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48532236
110Taste transduction_Homo sapiens_hsa047420.48398134
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47891132
112Phagosome_Homo sapiens_hsa041450.47499900
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.47193419
114Insulin resistance_Homo sapiens_hsa049310.45231267
115Linoleic acid metabolism_Homo sapiens_hsa005910.45185939
116Glycerolipid metabolism_Homo sapiens_hsa005610.43757750
117Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.42434056
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.41890304
119Non-homologous end-joining_Homo sapiens_hsa034500.40964253
120Cysteine and methionine metabolism_Homo sapiens_hsa002700.38758598
121Cardiac muscle contraction_Homo sapiens_hsa042600.38456959
122Rheumatoid arthritis_Homo sapiens_hsa053230.37903192
123Prion diseases_Homo sapiens_hsa050200.37505882
124Ether lipid metabolism_Homo sapiens_hsa005650.36570629
125Renin secretion_Homo sapiens_hsa049240.33773024
126Pyrimidine metabolism_Homo sapiens_hsa002400.30887470
127Salivary secretion_Homo sapiens_hsa049700.30846148
128Serotonergic synapse_Homo sapiens_hsa047260.29259350
129Glycerophospholipid metabolism_Homo sapiens_hsa005640.26374170

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