TMED5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of fibrinolysis (GO:0051918)4.08286224
2low-density lipoprotein particle clearance (GO:0034383)3.81808613
3regulation of protein activation cascade (GO:2000257)3.65627280
4very-low-density lipoprotein particle assembly (GO:0034379)3.60810775
5fatty acid elongation (GO:0030497)3.60551252
6regulation of complement activation (GO:0030449)3.58298296
7regulation of fibrinolysis (GO:0051917)3.54344263
8cellular response to ethanol (GO:0071361)3.46816270
9oligosaccharide catabolic process (GO:0009313)3.45758175
10ribosomal small subunit biogenesis (GO:0042274)3.44348866
11alpha-linolenic acid metabolic process (GO:0036109)3.42432970
12complement activation, alternative pathway (GO:0006957)3.40688871
13proteasome assembly (GO:0043248)3.37331636
14detection of molecule of bacterial origin (GO:0032490)3.35813174
15negative regulation of protein activation cascade (GO:2000258)3.33445868
16positive regulation of blood coagulation (GO:0030194)3.24779981
17positive regulation of hemostasis (GO:1900048)3.24779981
18axon ensheathment in central nervous system (GO:0032291)3.24491307
19central nervous system myelination (GO:0022010)3.24491307
20cell adhesion mediated by integrin (GO:0033627)3.24000006
21glycosphingolipid catabolic process (GO:0046479)3.21081344
22positive regulation of coagulation (GO:0050820)3.15468991
23negative regulation of complement activation (GO:0045916)3.13319376
24plasma lipoprotein particle assembly (GO:0034377)3.12097222
25termination of RNA polymerase I transcription (GO:0006363)3.10931586
26positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.10270013
27COPII vesicle coating (GO:0048208)3.09562230
28regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.08749231
29iron ion import (GO:0097286)3.07829516
30protein-lipid complex assembly (GO:0065005)3.03350143
31termination of RNA polymerase III transcription (GO:0006386)3.01994467
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.01994467
33rRNA modification (GO:0000154)3.00519681
34embryonic process involved in female pregnancy (GO:0060136)3.00202540
35plasma lipoprotein particle clearance (GO:0034381)2.99047458
36transcription from RNA polymerase I promoter (GO:0006360)2.97223884
37DNA deamination (GO:0045006)2.94962668
38maturation of SSU-rRNA (GO:0030490)2.93136731
39fibrinolysis (GO:0042730)2.92832434
40positive regulation of extracellular matrix organization (GO:1903055)2.91305524
41cholesterol efflux (GO:0033344)2.91012009
42transcription elongation from RNA polymerase I promoter (GO:0006362)2.89215064
43glycolipid catabolic process (GO:0019377)2.88463363
44detection of other organism (GO:0098543)2.86590484
45nuclear pore complex assembly (GO:0051292)2.82750409
467-methylguanosine mRNA capping (GO:0006370)2.82217184
47GPI anchor biosynthetic process (GO:0006506)2.82201142
48regulation of cholesterol homeostasis (GO:2000188)2.80861045
49RNA capping (GO:0036260)2.78941065
507-methylguanosine RNA capping (GO:0009452)2.78941065
51lipopolysaccharide-mediated signaling pathway (GO:0031663)2.78875837
52ribosomal large subunit biogenesis (GO:0042273)2.78869981
53neutrophil activation involved in immune response (GO:0002283)2.76674095
54transcription initiation from RNA polymerase I promoter (GO:0006361)2.75650917
55low-density lipoprotein particle remodeling (GO:0034374)2.70131613
56ribosome assembly (GO:0042255)2.70025889
57detection of bacterium (GO:0016045)2.68414067
58pinocytosis (GO:0006907)2.67972919
59positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.66697425
60peptidyl-glutamic acid carboxylation (GO:0017187)2.65703436
61protein carboxylation (GO:0018214)2.65703436
62regulation of cholesterol storage (GO:0010885)2.64507585
63positive regulation of gamma-delta T cell activation (GO:0046645)2.64331006
64Golgi transport vesicle coating (GO:0048200)2.63258293
65COPI coating of Golgi vesicle (GO:0048205)2.63258293
66ribonucleoprotein complex biogenesis (GO:0022613)2.61454503
67preassembly of GPI anchor in ER membrane (GO:0016254)2.60157563
68acute-phase response (GO:0006953)2.60015540
69cellular extravasation (GO:0045123)2.59811831
70positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.59290381
71positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.58857027
72response to thyroid hormone (GO:0097066)2.58666690
73CENP-A containing nucleosome assembly (GO:0034080)2.56955600
74plasma lipoprotein particle organization (GO:0071827)2.56587150
75negative regulation of humoral immune response (GO:0002921)2.55236493
76protein-lipid complex subunit organization (GO:0071825)2.55180263
77negative regulation of interleukin-12 production (GO:0032695)2.52840708
78GPI anchor metabolic process (GO:0006505)2.52751789
79protein localization to endosome (GO:0036010)2.52730647
80cellular response to thyroid hormone stimulus (GO:0097067)2.50367739
81viral transcription (GO:0019083)2.49970418
82regulation of apoptotic cell clearance (GO:2000425)2.49569814
83deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.49502661
84nucleotide transmembrane transport (GO:1901679)2.49403378
85cotranslational protein targeting to membrane (GO:0006613)2.48983453
86ribosomal small subunit assembly (GO:0000028)2.48615882
87protein-lipid complex remodeling (GO:0034368)2.48597456
88macromolecular complex remodeling (GO:0034367)2.48597456
89plasma lipoprotein particle remodeling (GO:0034369)2.48597456
90response to laminar fluid shear stress (GO:0034616)2.48516008
91telomere maintenance via semi-conservative replication (GO:0032201)2.48289528
92rRNA methylation (GO:0031167)2.48179077
93negative regulation of fatty acid biosynthetic process (GO:0045717)2.47368502
94regulation of activation of Janus kinase activity (GO:0010533)2.46234046
95translational termination (GO:0006415)2.46141961
96superoxide anion generation (GO:0042554)2.45366637
97SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.43998255
98positive regulation of cellular amine metabolic process (GO:0033240)2.43726540
99ceramide catabolic process (GO:0046514)2.42976470
100protein targeting to ER (GO:0045047)2.42707147
101regulation of humoral immune response (GO:0002920)2.42404910
102UDP-N-acetylglucosamine metabolic process (GO:0006047)2.42258080
103lipoprotein metabolic process (GO:0042157)2.41920573
104cholesterol biosynthetic process (GO:0006695)2.40507753
105rRNA processing (GO:0006364)2.40474061
106phospholipid efflux (GO:0033700)2.40086978
107protein localization to endoplasmic reticulum (GO:0070972)2.39801151
108necroptotic process (GO:0070266)2.38592921
109transcription-coupled nucleotide-excision repair (GO:0006283)2.37921875
110response to interferon-beta (GO:0035456)2.37916937
111chromatin remodeling at centromere (GO:0031055)2.37258243
112positive regulation of cellular amide metabolic process (GO:0034250)2.36866623
113urea metabolic process (GO:0019627)2.36836905
114nuclear pore organization (GO:0006999)2.34367042
115aldehyde catabolic process (GO:0046185)2.34225041
116L-serine metabolic process (GO:0006563)2.34051867
117phospholipid homeostasis (GO:0055091)2.34028926
118negative regulation of cholesterol transport (GO:0032375)2.33854129
119negative regulation of sterol transport (GO:0032372)2.33854129
120osteoclast differentiation (GO:0030316)2.33236800
121amino acid salvage (GO:0043102)2.32557761
122L-methionine salvage (GO:0071267)2.32557761
123L-methionine biosynthetic process (GO:0071265)2.32557761
124telomere maintenance via recombination (GO:0000722)2.32033240
125positive regulation of interferon-alpha production (GO:0032727)2.31915606
126establishment of protein localization to endoplasmic reticulum (GO:0072599)2.31403697
127regulation of interferon-alpha production (GO:0032647)2.30262422
128fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.30014141
129regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.29990857
130positive regulation of lipid storage (GO:0010884)2.29725125
131rRNA metabolic process (GO:0016072)2.29618568
132L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.28963649
133exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.28701265
134dicarboxylic acid biosynthetic process (GO:0043650)2.28310969
135pyrimidine-containing compound transmembrane transport (GO:0072531)2.28253007
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.28192990
137antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.27600132
138response to peptidoglycan (GO:0032494)2.27508443
139signal peptide processing (GO:0006465)2.27464774
140regulation of vitamin D biosynthetic process (GO:0060556)2.27451277
141antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.27337233
142regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26490581
143negative regulation of blood coagulation (GO:0030195)2.25948495
144negative regulation of hemostasis (GO:1900047)2.25948495
145complement activation, classical pathway (GO:0006958)2.25662482
146G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.25458516
147ribosome biogenesis (GO:0042254)2.24386900
148interleukin-6-mediated signaling pathway (GO:0070102)2.23949604
149protein activation cascade (GO:0072376)2.23609157
150hypotonic response (GO:0006971)2.23598893
151regulation of response to interferon-gamma (GO:0060330)2.23576898
152positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.23496094
153regulation of vitamin metabolic process (GO:0030656)2.22599072
154complement activation (GO:0006956)2.22056171
155antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.22052081
156sphingosine metabolic process (GO:0006670)2.22023843
157regulation of cholesterol esterification (GO:0010872)2.22022184
158negative regulation of coagulation (GO:0050819)2.21901897
159urea cycle (GO:0000050)2.21405939
160membrane raft organization (GO:0031579)2.20815583
161response to muramyl dipeptide (GO:0032495)2.20427378
162long-chain fatty acid biosynthetic process (GO:0042759)2.20240633
163pseudouridine synthesis (GO:0001522)2.19798256
164deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.19584191
165deoxyribonucleotide biosynthetic process (GO:0009263)2.19439221
166sphingoid metabolic process (GO:0046519)2.18885606
167negative regulation of lipid transport (GO:0032369)2.18561783
168regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.17850420
169regulation of antigen processing and presentation (GO:0002577)2.17542007
170fatty acid homeostasis (GO:0055089)2.17346802
171peptidyl-histidine modification (GO:0018202)2.16369964
172positive regulation of toll-like receptor signaling pathway (GO:0034123)2.15527493
173respiratory burst (GO:0045730)2.15289716
174kinetochore organization (GO:0051383)2.14435393
175NAD biosynthetic process (GO:0009435)2.13409181
176protein neddylation (GO:0045116)2.12521938
177sterol biosynthetic process (GO:0016126)2.12203890
178negative regulation of execution phase of apoptosis (GO:1900118)2.11674714
179DNA-dependent DNA replication (GO:0006261)2.11137853
180positive regulation of interleukin-17 production (GO:0032740)2.10859840
181cellular response to interferon-beta (GO:0035458)2.10495501
182cellular component biogenesis (GO:0044085)2.10425182
183isoprenoid biosynthetic process (GO:0008299)2.09926922
184translation (GO:0006412)2.09916910
185cyclooxygenase pathway (GO:0019371)2.09555081
186regulation of metalloenzyme activity (GO:0048552)2.09519375
187negative regulation of mast cell activation (GO:0033004)2.08225492
188amyloid precursor protein metabolic process (GO:0042982)2.06448077
189neutrophil activation (GO:0042119)2.05810274
190detection of external biotic stimulus (GO:0098581)2.05044860
191serine family amino acid biosynthetic process (GO:0009070)2.03619789
192regulation of T cell migration (GO:2000404)2.03276692
193regulation of interleukin-8 biosynthetic process (GO:0045414)2.02408146
194DNA replication initiation (GO:0006270)2.02247584
195kinetochore assembly (GO:0051382)2.01934341
196positive regulation of viral transcription (GO:0050434)2.00541103

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.46233344
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.35727811
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.17320923
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.91672609
5E2F7_22180533_ChIP-Seq_HELA_Human3.70651459
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.32891264
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.30748945
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.28593387
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.13580054
10ELF1_17652178_ChIP-ChIP_JURKAT_Human2.85395120
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.82951167
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.67986385
13EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67930618
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.61620160
15MYC_18555785_ChIP-Seq_MESCs_Mouse2.56378225
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.44162714
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.42959132
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.38228074
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.32466434
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.32087400
21CLOCK_20551151_ChIP-Seq_293T_Human2.29008162
22LXR_22158963_ChIP-Seq_LIVER_Mouse2.28197256
23ELK1_19687146_ChIP-ChIP_HELA_Human2.23001121
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.22381437
25IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18482898
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16926083
27GATA1_22025678_ChIP-Seq_K562_Human2.15208251
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.13602081
29* ETS1_20019798_ChIP-Seq_JURKAT_Human2.09131776
30* VDR_23849224_ChIP-Seq_CD4+_Human2.08123908
31SALL4_18804426_ChIP-ChIP_XEN_Mouse2.06448249
32* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.05100795
33* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.04804796
34PPARA_22158963_ChIP-Seq_LIVER_Mouse2.00508831
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.00292812
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.98527584
37TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.94757111
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.89180689
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.88209038
40* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.81525663
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.77656791
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77388320
43* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77128333
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.76589497
45SRF_21415370_ChIP-Seq_HL-1_Mouse1.73516349
46GATA2_21666600_ChIP-Seq_HMVEC_Human1.69370304
47TP63_17297297_ChIP-ChIP_HaCaT_Human1.68590792
48* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.67165268
49* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.65768589
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.65323558
51SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.64451152
52SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.64451152
53SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.64211887
54BRD4_27068464_Chip-Seq_AML-cells_Mouse1.62081335
55FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.61618764
56TFEB_21752829_ChIP-Seq_HELA_Human1.59412325
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57389868
58DCP1A_22483619_ChIP-Seq_HELA_Human1.57309011
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.56878852
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.55440267
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54509893
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.47879112
63NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.47574092
64FOXP3_21729870_ChIP-Seq_TREG_Human1.46648548
65VDR_24787735_ChIP-Seq_THP-1_Human1.45307024
66SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44415523
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.43952533
68PU_27001747_Chip-Seq_BMDM_Mouse1.43351155
69* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.43074046
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42802386
71IRF1_19129219_ChIP-ChIP_H3396_Human1.40178956
72PPAR_26484153_Chip-Seq_NCI-H1993_Human1.39578787
73* SPI1_23547873_ChIP-Seq_NB4_Human1.38408045
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38110528
75STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38037280
76SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37557307
77FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.34614515
78FOXO3_23340844_ChIP-Seq_DLD1_Human1.33293408
79FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33184388
80* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32089100
81* MYB_26560356_Chip-Seq_TH2_Human1.31155291
82MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.31057547
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30517136
84ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29342494
85WT1_19549856_ChIP-ChIP_CCG9911_Human1.28054030
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.23451581
87KAP1_22055183_ChIP-Seq_ESCs_Mouse1.22556744
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.21432886
89* MYB_26560356_Chip-Seq_TH1_Human1.21259806
90BRD4_25478319_ChIP-Seq_HGPS_Human1.20298266
91SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20198515
92STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.19919963
93MYC_18940864_ChIP-ChIP_HL60_Human1.19356606
94RUNX_20019798_ChIP-Seq_JUKART_Human1.19020314
95* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18863461
96PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18473820
97ELK1_22589737_ChIP-Seq_MCF10A_Human1.18092349
98MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17012407
99Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16921279
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16776320
101ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.16045528
102AR_21909140_ChIP-Seq_LNCAP_Human1.15741155
103NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15471186
104FOXA2_19822575_ChIP-Seq_HepG2_Human1.14358860
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13846697
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.13511050
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.13511050
108CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11631359
109EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.10830151
110* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.10652093
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09977166
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.09685343
113XRN2_22483619_ChIP-Seq_HELA_Human1.09351423
114* SOX2_20726797_ChIP-Seq_SW620_Human1.08049896
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.07980965
116TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07552474
117SPI1_23127762_ChIP-Seq_K562_Human1.07176872
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.06686046
119IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06073963
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.06054473
121MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.04742978
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.04607893
123TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.04124469
124CJUN_26792858_Chip-Seq_BT549_Human1.03071659
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02954373
126KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02455564
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02320537
128PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00964601
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99305596
130PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99251081
131RUNX1_22412390_ChIP-Seq_EML_Mouse0.96807117
132GATA6_25053715_ChIP-Seq_YYC3_Human0.95711236
133EZH2_27294783_Chip-Seq_NPCs_Mouse0.94317664
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94316235
135TTF2_22483619_ChIP-Seq_HELA_Human0.93409042
136KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.92319264
137* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.92048372
138PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.92030935
139BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91955410
140JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91097174
141PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90817852
142SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.90807722
143GATA3_26560356_Chip-Seq_TH2_Human0.90758024
144JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90134415
145* HNF4A_19822575_ChIP-Seq_HepG2_Human0.89805663
146* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.89073868
147TAF15_26573619_Chip-Seq_HEK293_Human0.88881063
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88420516
149HTT_18923047_ChIP-ChIP_STHdh_Human0.88395224
150GATA4_25053715_ChIP-Seq_YYC3_Human0.87319584
151GATA3_27048872_Chip-Seq_THYMUS_Human0.87102398
152UBF1/2_26484160_Chip-Seq_HMECs_Human0.86581100
153HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.86076824
154MYCN_18555785_ChIP-Seq_MESCs_Mouse0.85960499
155TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85678744
156AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.85040674
157SOX17_20123909_ChIP-Seq_XEN_Mouse0.84216161
158PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.80907034
159CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80166440
160ER_23166858_ChIP-Seq_MCF-7_Human0.79901245
161* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.79680431
162NANOG_18555785_ChIP-Seq_MESCs_Mouse0.78755718
163GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.76609690
164RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.76496822
165ZFP57_27257070_Chip-Seq_ESCs_Mouse0.76464343
166CRX_20693478_ChIP-Seq_RETINA_Mouse0.76213179
167SMAD1_18555785_Chip-Seq_ESCs_Mouse0.76154273
168PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.74759625
169PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.73882004
170RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73540192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to2.95039384
2MP0001835_abnormal_antigen_presentation2.74224494
3MP0004381_abnormal_hair_follicle2.72901576
4MP0003806_abnormal_nucleotide_metabolis2.67915795
5MP0005451_abnormal_body_composition2.64724597
6MP0003300_gastrointestinal_ulcer2.63926174
7MP0003136_yellow_coat_color2.50057119
8MP0003950_abnormal_plasma_membrane2.44774746
9MP0009785_altered_susceptibility_to2.39560610
10MP0008057_abnormal_DNA_replication2.30124304
11MP0003303_peritoneal_inflammation2.19370298
12MP0003186_abnormal_redox_activity2.16435998
13MP0002148_abnormal_hypersensitivity_rea2.12046945
14MP0005671_abnormal_response_to2.09682511
15MP0001853_heart_inflammation2.06092098
16MP0002796_impaired_skin_barrier2.04214562
17MP0002419_abnormal_innate_immunity2.01639217
18MP0002877_abnormal_melanocyte_morpholog2.01087368
19MP0006082_CNS_inflammation2.00794201
20MP0003436_decreased_susceptibility_to2.00760794
21MP0003718_maternal_effect1.98953993
22MP0005000_abnormal_immune_tolerance1.98824509
23MP0009379_abnormal_foot_pigmentation1.98324346
24MP0005025_abnormal_response_to1.87689634
25MP0010352_gastrointestinal_tract_polyps1.87283601
26MP0002139_abnormal_hepatobiliary_system1.84540196
27MP0003656_abnormal_erythrocyte_physiolo1.82373107
28MP0009333_abnormal_splenocyte_physiolog1.76959455
29MP0006054_spinal_hemorrhage1.72862772
30MP0002132_abnormal_respiratory_system1.71333751
31MP0003252_abnormal_bile_duct1.69817195
32MP0002723_abnormal_immune_serum1.67331005
33MP0001800_abnormal_humoral_immune1.66870276
34MP0002452_abnormal_antigen_presenting1.62903355
35MP0003172_abnormal_lysosome_physiology1.61091664
36MP0002166_altered_tumor_susceptibility1.57973474
37MP0001790_abnormal_immune_system1.55430536
38MP0005387_immune_system_phenotype1.55430536
39MP0000920_abnormal_myelination1.54138623
40MP0002009_preneoplasia1.54125385
41MP0009764_decreased_sensitivity_to1.51266238
42MP0003868_abnormal_feces_composition1.49343759
43MP0005408_hypopigmentation1.48917816
44MP0003566_abnormal_cell_adhesion1.48385016
45MP0003693_abnormal_embryo_hatching1.48359864
46MP0010234_abnormal_vibrissa_follicle1.46267315
47MP0003191_abnormal_cellular_cholesterol1.43786234
48MP0003091_abnormal_cell_migration1.43540286
49MP0005501_abnormal_skin_physiology1.41796831
50MP0002420_abnormal_adaptive_immunity1.40022448
51MP0001819_abnormal_immune_cell1.39166978
52MP0000566_synostosis1.37392833
53MP0000609_abnormal_liver_physiology1.35989486
54MP0010329_abnormal_lipoprotein_level1.30349026
55MP0000604_amyloidosis1.29122514
56MP0004782_abnormal_surfactant_physiolog1.27784973
57MP0005085_abnormal_gallbladder_physiolo1.26641839
58MP0004947_skin_inflammation1.26268468
59MP0008438_abnormal_cutaneous_collagen1.24907160
60MP0001542_abnormal_bone_strength1.24567841
61MP0008469_abnormal_protein_level1.24540878
62MP0008058_abnormal_DNA_repair1.24443555
63MP0001915_intracranial_hemorrhage1.24252051
64MP0002405_respiratory_system_inflammati1.21666903
65MP0001986_abnormal_taste_sensitivity1.21425017
66MP0003690_abnormal_glial_cell1.21291436
67MP0005409_darkened_coat_color1.20064448
68MP0002277_abnormal_respiratory_mucosa1.19950384
69MP0003941_abnormal_skin_development1.18306925
70MP0009840_abnormal_foam_cell1.17802637
71MP0001666_abnormal_nutrient_absorption1.16241079
72MP0005075_abnormal_melanosome_morpholog1.15786505
73MP0005464_abnormal_platelet_physiology1.15574733
74MP0003183_abnormal_peptide_metabolism1.15277011
75MP0003075_altered_response_to1.15078930
76MP0000685_abnormal_immune_system1.14592457
77MP0001764_abnormal_homeostasis1.14069857
78MP0001216_abnormal_epidermal_layer1.13274957
79MP0001851_eye_inflammation1.12408708
80MP0008875_abnormal_xenobiotic_pharmacok1.12231300
81MP0000465_gastrointestinal_hemorrhage1.10875699
82MP0010155_abnormal_intestine_physiology1.10015807
83MP0001661_extended_life_span1.09479070
84MP0005023_abnormal_wound_healing1.09477463
85MP0001533_abnormal_skeleton_physiology1.09406318
86MP0002998_abnormal_bone_remodeling1.09285836
87MP0001845_abnormal_inflammatory_respons1.09048688
88MP0002971_abnormal_brown_adipose1.08559599
89MP0003786_premature_aging1.05632147
90MP0003195_calcinosis1.05411748
91MP0000716_abnormal_immune_system1.04959980
92MP0009697_abnormal_copulation1.04497468
93MP0008260_abnormal_autophagy1.04349804
94MP0005058_abnormal_lysosome_morphology1.04248556
95MP0003705_abnormal_hypodermis_morpholog1.04016482
96MP0002060_abnormal_skin_morphology1.03678240
97MP0005670_abnormal_white_adipose1.03152274
98MP0003221_abnormal_cardiomyocyte_apopto1.02972431
99MP0000689_abnormal_spleen_morphology1.02930005
100MP0005076_abnormal_cell_differentiation1.02115053
101MP0004883_abnormal_blood_vessel1.01999165
102MP0002006_tumorigenesis1.01626843
103MP0002254_reproductive_system_inflammat1.01520605
104MP0003448_altered_tumor_morphology1.00414062
105MP0000383_abnormal_hair_follicle1.00102182
106MP0003763_abnormal_thymus_physiology0.99194961
107MP0009763_increased_sensitivity_to0.98957737
108MP0002396_abnormal_hematopoietic_system0.98047312
109MP0005360_urolithiasis0.97380258
110MP0008004_abnormal_stomach_pH0.96460298
111MP0000343_altered_response_to0.95922205
112MP0004272_abnormal_basement_membrane0.94255877
113MP0002118_abnormal_lipid_homeostasis0.93004306
114MP0003453_abnormal_keratinocyte_physiol0.91973459
115MP0002398_abnormal_bone_marrow0.91097435
116MP0004808_abnormal_hematopoietic_stem0.90969784
117MP0005166_decreased_susceptibility_to0.90889903
118MP0008007_abnormal_cellular_replicative0.90174815
119MP0005666_abnormal_adipose_tissue0.89787364
120MP0000647_abnormal_sebaceous_gland0.89749750
121MP0002722_abnormal_immune_system0.89737837
122MP0005332_abnormal_amino_acid0.89222344
123MP0005395_other_phenotype0.88780299
124MP0005319_abnormal_enzyme/_coenzyme0.88222408
125MP0004147_increased_porphyrin_level0.87369202
126MP0004957_abnormal_blastocyst_morpholog0.86936616
127MP0005165_increased_susceptibility_to0.86836112
128MP0005584_abnormal_enzyme/coenzyme_acti0.86822370
129MP0000249_abnormal_blood_vessel0.86463523
130MP0005365_abnormal_bile_salt0.86371562
131MP0000598_abnormal_liver_morphology0.86015254
132MP0000372_irregular_coat_pigmentation0.85954370
133MP0002138_abnormal_hepatobiliary_system0.85442977
134MP0003045_fibrosis0.84969379
135MP0005275_abnormal_skin_tensile0.84594666
136MP0002429_abnormal_blood_cell0.84202804
137MP0001243_abnormal_dermal_layer0.83576302
138MP0009765_abnormal_xenobiotic_induced0.83567670
139MP0001188_hyperpigmentation0.83500562
140MP0005164_abnormal_response_to0.83472026
141MP0004233_abnormal_muscle_weight0.82448321
142MP0003828_pulmonary_edema0.81655135
143MP0000858_altered_metastatic_potential0.81135713
144MP0005647_abnormal_sex_gland0.79701660

Predicted human phenotypes

RankGene SetZ-score
1Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.23632821
2Deep venous thrombosis (HP:0002625)4.49461389
3Congenital ichthyosiform erythroderma (HP:0007431)4.14469972
4Abnormality of glycolipid metabolism (HP:0010969)4.04244976
5Abnormality of liposaccharide metabolism (HP:0010968)4.04244976
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.04244976
7Abnormality of the common coagulation pathway (HP:0010990)4.01106925
8Myocardial infarction (HP:0001658)3.93465385
9Complement deficiency (HP:0004431)3.80250604
10Parakeratosis (HP:0001036)3.77887442
11Hypobetalipoproteinemia (HP:0003563)3.53484206
12Abnormality of complement system (HP:0005339)3.38532061
13Systemic lupus erythematosus (HP:0002725)3.36589000
14Hepatosplenomegaly (HP:0001433)3.24824485
15Duplicated collecting system (HP:0000081)3.24336072
16Erythroderma (HP:0001019)3.20329939
17Eczematoid dermatitis (HP:0000976)3.00809568
18Glomerulonephritis (HP:0000099)2.97983364
19Dysostosis multiplex (HP:0000943)2.92783209
20Xanthomatosis (HP:0000991)2.88006933
213-Methylglutaconic aciduria (HP:0003535)2.86500929
22Recurrent abscess formation (HP:0002722)2.82287173
23Abnormality of the renal collecting system (HP:0004742)2.78156915
24Mucopolysacchariduria (HP:0008155)2.75203024
25Urinary glycosaminoglycan excretion (HP:0003541)2.75203024
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.74246191
27Abnormality of macrophages (HP:0004311)2.72497796
28Abnormality of secondary sexual hair (HP:0009888)2.70082937
29Abnormality of the axillary hair (HP:0100134)2.70082937
30Renal Fanconi syndrome (HP:0001994)2.66241290
31Prolonged partial thromboplastin time (HP:0003645)2.65416994
32Abnormality of polysaccharide metabolism (HP:0011012)2.62883317
33Abnormality of glycosaminoglycan metabolism (HP:0004371)2.62883317
34Abnormality of mucopolysaccharide metabolism (HP:0011020)2.62883317
35Recurrent bacterial skin infections (HP:0005406)2.62684035
36Gingival bleeding (HP:0000225)2.62160715
37Gangrene (HP:0100758)2.57190964
38Hypolipoproteinemia (HP:0010981)2.53976917
39Prolonged neonatal jaundice (HP:0006579)2.47879430
40Fatigue (HP:0012378)2.46272272
41Conjugated hyperbilirubinemia (HP:0002908)2.43673547
42Birth length less than 3rd percentile (HP:0003561)2.43266596
43Abnormality of the intrinsic pathway (HP:0010989)2.42507170
44Optic neuritis (HP:0100653)2.40392590
45Retrobulbar optic neuritis (HP:0100654)2.40392590
46Tetraparesis (HP:0002273)2.39697860
47Granulocytopenia (HP:0001913)2.38710838
48Breast hypoplasia (HP:0003187)2.38359053
49Fat malabsorption (HP:0002630)2.37412757
50Skin nodule (HP:0200036)2.36997456
51Chronic obstructive pulmonary disease (HP:0006510)2.35964880
52Obstructive lung disease (HP:0006536)2.35964880
53Mitral stenosis (HP:0001718)2.33646961
54Joint hemorrhage (HP:0005261)2.31544748
55Stomatitis (HP:0010280)2.30985096
56Ectropion (HP:0000656)2.29716522
57Recurrent skin infections (HP:0001581)2.29663659
58Reticulocytopenia (HP:0001896)2.28435520
59Macrocytic anemia (HP:0001972)2.26365744
60Recurrent gram-negative bacterial infections (HP:0005420)2.25368993
61Vertebral compression fractures (HP:0002953)2.24375330
62Prostate neoplasm (HP:0100787)2.23589097
63Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.23033037
64Hypercholesterolemia (HP:0003124)2.22899751
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.22369552
66Myositis (HP:0100614)2.21540470
67Increased hepatocellular lipid droplets (HP:0006565)2.19848761
68Loss of speech (HP:0002371)2.17605096
69Chromosomal breakage induced by crosslinking agents (HP:0003221)2.16931960
70Abnormal foot bone ossification (HP:0010675)2.16808236
71Subacute progressive viral hepatitis (HP:0006572)2.16751442
72Orchitis (HP:0100796)2.15392884
73Increased cerebral lipofuscin (HP:0011813)2.14564980
74Hemorrhage of the eye (HP:0011885)2.14471450
75Amyloidosis (HP:0011034)2.14256619
76Vascular calcification (HP:0004934)2.12932912
77Type I transferrin isoform profile (HP:0003642)2.12749823
78Chromsome breakage (HP:0040012)2.12707133
79Reduced antithrombin III activity (HP:0001976)2.10782988
80Vacuolated lymphocytes (HP:0001922)2.10774050
81Epidermoid cyst (HP:0200040)2.10042040
82Asymmetric septal hypertrophy (HP:0001670)2.07779948
83Lower limb hyperreflexia (HP:0002395)2.06821423
84IgG deficiency (HP:0004315)2.06241756
85Nephritis (HP:0000123)2.04807971
86Intrahepatic cholestasis (HP:0001406)2.04769210
87Renal cortical cysts (HP:0000803)2.04493093
88Purpura (HP:0000979)2.04028589
89Encephalitis (HP:0002383)2.03816416
90Abnormality of methionine metabolism (HP:0010901)2.02919490
91Sparse eyelashes (HP:0000653)2.02693249
92Polycythemia (HP:0001901)2.02517964
93Abnormality of the prostate (HP:0008775)2.02506054
94Arterial thrombosis (HP:0004420)2.02145759
95Cardiovascular calcification (HP:0011915)2.01213821
96Elevated erythrocyte sedimentation rate (HP:0003565)1.99804975
97Increased mean platelet volume (HP:0011877)1.99049044
98Steatorrhea (HP:0002570)1.98876982
99Lipid accumulation in hepatocytes (HP:0006561)1.98705701
100Congenital, generalized hypertrichosis (HP:0004540)1.98612079
101Thick nail (HP:0001805)1.98496513
102Eosinophilia (HP:0001880)1.98119131
103IgM deficiency (HP:0002850)1.97023444
104Disinhibition (HP:0000734)1.94675754
105Coarse hair (HP:0002208)1.93998622
106Keratoconjunctivitis sicca (HP:0001097)1.93671133
107Abnormal platelet volume (HP:0011876)1.92666156
108Abnormality of the lumbar spine (HP:0100712)1.91559140
109Interstitial pulmonary disease (HP:0006530)1.90898954
110Esophageal varix (HP:0002040)1.90149917
111Exertional dyspnea (HP:0002875)1.89870301
112Thrombophlebitis (HP:0004418)1.89797033
113Abnormality of the vasculature of the conjunctiva (HP:0008054)1.89182500
114Abnormality of cells of the erythroid lineage (HP:0012130)1.88985056
115Recurrent pneumonia (HP:0006532)1.87156513
116Hepatocellular carcinoma (HP:0001402)1.87033704
117Mediastinal lymphadenopathy (HP:0100721)1.86111342
118Epistaxis (HP:0000421)1.85856855
119Conical tooth (HP:0000698)1.85484969
120Autoimmune hemolytic anemia (HP:0001890)1.84029126
121Flat acetabular roof (HP:0003180)1.83011944
122Autoimmune thrombocytopenia (HP:0001973)1.82937347
123Increased CSF protein (HP:0002922)1.82876783
124Abnormal number of erythroid precursors (HP:0012131)1.82377670
125Sensory axonal neuropathy (HP:0003390)1.81839327
126Abnormal platelet function (HP:0011869)1.81802885
127Impaired platelet aggregation (HP:0003540)1.81802885
128Entropion (HP:0000621)1.81292139
129Petechiae (HP:0000967)1.80984781
130Hematochezia (HP:0002573)1.80824685
131Abnormality of pyrimidine metabolism (HP:0004353)1.80361587
132Pancytopenia (HP:0001876)1.80282919
133Keratoconjunctivitis (HP:0001096)1.79946236
134Periodontitis (HP:0000704)1.79682045
135Hypoalphalipoproteinemia (HP:0003233)1.79018967
136Menorrhagia (HP:0000132)1.77780500
137Recurrent viral infections (HP:0004429)1.77174343
138Meningitis (HP:0001287)1.76968790
139Stenosis of the external auditory canal (HP:0000402)1.76448218
140Glomerulopathy (HP:0100820)1.75895733
141T lymphocytopenia (HP:0005403)1.75495588
142Pulmonary embolism (HP:0002204)1.75482996
143Pallor (HP:0000980)1.75467302
144Pruritus (HP:0000989)1.75363432
145Pulmonary infiltrates (HP:0002113)1.75154568
146Papillary thyroid carcinoma (HP:0002895)1.75084245
147Increased serum ferritin (HP:0003281)1.74655225
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.74643511
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.74559497
150Progressive external ophthalmoplegia (HP:0000590)1.74098901
151Stomach cancer (HP:0012126)1.74039388
152Abnormality of renal resorption (HP:0011038)1.73094324
153Syringomyelia (HP:0003396)1.72952193
154Spinal cord lesions (HP:0100561)1.72952193
155Abnormal spermatogenesis (HP:0008669)1.72729254
156Abnormality of T cell number (HP:0011839)1.71464642
157Erythema (HP:0010783)1.71367197
158Asymmetry of the thorax (HP:0001555)1.70656709
159Leukocytosis (HP:0001974)1.70482717
160Abnormality of eosinophils (HP:0001879)1.70072030
161Acute hepatic failure (HP:0006554)1.69706031
162Dry hair (HP:0011359)1.69621077
163Thickened calvaria (HP:0002684)1.69180068
164Upper motor neuron abnormality (HP:0002127)1.68587711
165Rough bone trabeculation (HP:0100670)1.67173249
166Vasculitis (HP:0002633)1.65985957
167Poor head control (HP:0002421)1.65979709
168Patchy hypopigmentation of hair (HP:0011365)1.65691966
169Autoamputation (HP:0001218)1.64351147
170Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64318186
171Azoospermia (HP:0000027)1.63617419
172Ureteral duplication (HP:0000073)1.63523824
173Recurrent cutaneous fungal infections (HP:0011370)1.63482590
174Chronic mucocutaneous candidiasis (HP:0002728)1.63482590
175Asplenia (HP:0001746)1.63149036
176Osteolytic defects of the phalanges of the hand (HP:0009771)1.63078362
177Osteolytic defects of the hand bones (HP:0009699)1.63078362
178Hyperlipoproteinemia (HP:0010980)1.63069350

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK34.01147919
2PBK3.22625185
3STK162.72232102
4IRAK42.60846395
5NME22.50868220
6MST42.47204803
7EIF2AK12.29414085
8TXK2.22037540
9PLK42.18910413
10EIF2AK32.13551617
11SRPK12.09917317
12SCYL22.03171179
13JAK11.98309401
14ERN11.98274133
15BUB11.94536760
16MAP3K141.94463018
17FGFR41.89919960
18ZAK1.88255555
19CAMKK21.86216932
20CDK61.85495780
21FGFR31.85445815
22NEK61.76875890
23BLK1.75004481
24PRPF4B1.74881945
25MAP3K21.70512173
26WEE11.70102715
27EIF2AK21.66753546
28MAP2K31.65596510
29LATS11.64409409
30VRK11.63852644
31MKNK21.55922922
32BRSK21.53406943
33IRAK11.52652301
34MAP3K131.51058582
35IRAK21.47200482
36CDK121.47138898
37STK391.44424904
38MKNK11.42485387
39TEC1.42207971
40KSR21.38135976
41MAP3K31.37877813
42TLK11.37238558
43CLK11.33821807
44MST1R1.32503703
45PDGFRA1.32033384
46IKBKB1.31323886
47ERBB31.26584810
48NEK11.25868715
49MAP4K11.24651510
50AKT31.21050662
51BMPR1B1.19883805
52PIM21.19132585
53ABL21.18456898
54STK101.16483330
55NLK1.13758785
56NEK91.13002750
57KIT1.11109186
58TYK21.09700774
59TTN1.08482963
60STK241.08427139
61BRD41.08193475
62KDR1.03824866
63GRK71.03695046
64PDK20.99662392
65RIPK40.97869411
66ADRBK20.96016594
67GRK10.95589003
68NUAK10.95011327
69OXSR10.93918222
70PKN10.92044682
71TESK20.91962913
72STK40.91229765
73LATS20.90355718
74JAK30.89940647
75MAPK110.89456166
76MAPKAPK50.88236330
77PRKAA20.87743985
78ITK0.87579877
79JAK20.87297514
80CAMK1D0.86292608
81BCKDK0.86243135
82RPS6KA50.86171228
83DDR20.86072516
84MAP3K10.85751717
85RIPK10.84192305
86PDGFRB0.82234158
87MOS0.80620513
88LYN0.80226301
89BMPR20.79883049
90IKBKE0.79776880
91DYRK30.79585905
92PIK3CG0.79335439
93KSR10.78204726
94BTK0.78036624
95SIK30.75875820
96MELK0.75093954
97LCK0.73837542
98ACVR1B0.73356444
99MAP3K120.73234637
100YES10.72772621
101EPHB10.71170102
102PLK30.71109500
103PAK40.70524801
104TRPM70.69269887
105CSF1R0.68623295
106TTK0.68552602
107PDPK10.68280060
108FGR0.67024056
109PIM10.66453789
110MAP3K50.65994360
111TNIK0.65961867
112STK30.65596203
113ICK0.65193319
114CSK0.63782633
115TGFBR20.62039515
116TAOK20.61462117
117SYK0.60488601
118MARK30.59696356
119ERBB40.59127261
120RAF10.57692019
121MATK0.57495365
122EPHA30.55037872
123TSSK60.54537388
124MET0.53738091
125EEF2K0.52945308
126CSNK1G30.52357884
127PDK10.52351056
128DYRK20.52175781
129SGK30.50896156
130CDK70.50775005
131MAPK150.50324464
132MAP3K60.49989664
133PLK10.48831444
134STK38L0.48456681
135MAP3K80.48253414
136CSNK2A10.47343026
137RPS6KA40.47208808
138RET0.47163655
139PRKCQ0.46526986
140BCR0.46491787
141PINK10.46238822
142CDC70.46062936
143CSNK1G10.45880086
144TBK10.45800297
145TAOK30.45482022
146ABL10.44340978
147WNK10.43661161
148CAMK1G0.43329346
149HCK0.43183169
150AURKB0.43077076
151CSNK1A1L0.42856201
152EPHA20.42822855
153ZAP700.42596662
154CDK40.42252205
155CDC42BPA0.41215534
156FER0.41167472
157AURKA0.41061792
158IGF1R0.40624264

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.91168032
2RNA polymerase_Homo sapiens_hsa030202.89165281
3Proteasome_Homo sapiens_hsa030502.44455870
4Protein export_Homo sapiens_hsa030602.30101098
5Fatty acid elongation_Homo sapiens_hsa000622.29367400
6Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.20432282
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.18213394
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.17202706
9Steroid biosynthesis_Homo sapiens_hsa001002.07952078
10DNA replication_Homo sapiens_hsa030302.00804478
11Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.89287083
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.86130135
13Pyrimidine metabolism_Homo sapiens_hsa002401.84545855
14Homologous recombination_Homo sapiens_hsa034401.70996889
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.70729018
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.64757149
17Mismatch repair_Homo sapiens_hsa034301.60026970
18Vitamin B6 metabolism_Homo sapiens_hsa007501.59975465
19Staphylococcus aureus infection_Homo sapiens_hsa051501.59255550
20Osteoclast differentiation_Homo sapiens_hsa043801.53925490
21Basal transcription factors_Homo sapiens_hsa030221.52295253
22Nucleotide excision repair_Homo sapiens_hsa034201.51385760
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50012948
24Fatty acid biosynthesis_Homo sapiens_hsa000611.49769754
25Folate biosynthesis_Homo sapiens_hsa007901.49637325
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.49422528
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49239910
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48651602
29TNF signaling pathway_Homo sapiens_hsa046681.44261545
30Histidine metabolism_Homo sapiens_hsa003401.42239082
31Graft-versus-host disease_Homo sapiens_hsa053321.40442737
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.39354139
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.37217294
34Caffeine metabolism_Homo sapiens_hsa002321.31629369
35Allograft rejection_Homo sapiens_hsa053301.29782953
36Fanconi anemia pathway_Homo sapiens_hsa034601.28231623
37One carbon pool by folate_Homo sapiens_hsa006701.28111670
38Oxidative phosphorylation_Homo sapiens_hsa001901.27967778
39Ether lipid metabolism_Homo sapiens_hsa005651.27902185
40Toxoplasmosis_Homo sapiens_hsa051451.26213198
41Spliceosome_Homo sapiens_hsa030401.25494770
42Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.24193907
43Sphingolipid metabolism_Homo sapiens_hsa006001.24016183
44Malaria_Homo sapiens_hsa051441.22362626
45Tuberculosis_Homo sapiens_hsa051521.22091555
46Glutathione metabolism_Homo sapiens_hsa004801.21179546
47Prion diseases_Homo sapiens_hsa050201.20021825
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.18417882
49Influenza A_Homo sapiens_hsa051641.18393264
50Complement and coagulation cascades_Homo sapiens_hsa046101.14389524
51Peroxisome_Homo sapiens_hsa041461.14291319
52Retinol metabolism_Homo sapiens_hsa008301.13710622
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11747163
54Starch and sucrose metabolism_Homo sapiens_hsa005001.10927865
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10873313
56Arachidonic acid metabolism_Homo sapiens_hsa005901.09382332
57Autoimmune thyroid disease_Homo sapiens_hsa053201.09322443
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.09233360
59Primary immunodeficiency_Homo sapiens_hsa053401.09084927
60B cell receptor signaling pathway_Homo sapiens_hsa046621.08871119
61Pancreatic cancer_Homo sapiens_hsa052121.08707515
62Non-homologous end-joining_Homo sapiens_hsa034501.08440684
63Intestinal immune network for IgA production_Homo sapiens_hsa046721.08319813
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.07692289
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.07630078
66Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06388396
67Steroid hormone biosynthesis_Homo sapiens_hsa001401.00902556
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.98803020
69Chronic myeloid leukemia_Homo sapiens_hsa052200.96876207
70Adipocytokine signaling pathway_Homo sapiens_hsa049200.95781746
71Rheumatoid arthritis_Homo sapiens_hsa053230.94909813
72beta-Alanine metabolism_Homo sapiens_hsa004100.94660483
73Pentose and glucuronate interconversions_Homo sapiens_hsa000400.94265393
74Chemical carcinogenesis_Homo sapiens_hsa052040.94253048
75Linoleic acid metabolism_Homo sapiens_hsa005910.93173680
76Hematopoietic cell lineage_Homo sapiens_hsa046400.93039340
77Asthma_Homo sapiens_hsa053100.92854339
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91934007
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.91901375
80Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90293730
81Hepatitis B_Homo sapiens_hsa051610.89704051
82Hepatitis C_Homo sapiens_hsa051600.89161696
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88633573
84Purine metabolism_Homo sapiens_hsa002300.85960517
85NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85755708
86Arginine biosynthesis_Homo sapiens_hsa002200.85398039
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.84939013
88Base excision repair_Homo sapiens_hsa034100.84674376
89RNA degradation_Homo sapiens_hsa030180.83518848
90Parkinsons disease_Homo sapiens_hsa050120.83272313
91Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83222963
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81852601
93SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81367664
94Vitamin digestion and absorption_Homo sapiens_hsa049770.79803715
95Measles_Homo sapiens_hsa051620.78013727
96Amoebiasis_Homo sapiens_hsa051460.77955748
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76756585
98Renal cell carcinoma_Homo sapiens_hsa052110.75917029
99Insulin resistance_Homo sapiens_hsa049310.75458380
100Salmonella infection_Homo sapiens_hsa051320.75457093
101Shigellosis_Homo sapiens_hsa051310.75345297
102p53 signaling pathway_Homo sapiens_hsa041150.74762815
103Leishmaniasis_Homo sapiens_hsa051400.74214445
104Galactose metabolism_Homo sapiens_hsa000520.73841414
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72630101
106Small cell lung cancer_Homo sapiens_hsa052220.72204149
107Arginine and proline metabolism_Homo sapiens_hsa003300.71764021
108RNA transport_Homo sapiens_hsa030130.70344062
109Bladder cancer_Homo sapiens_hsa052190.69881338
110Systemic lupus erythematosus_Homo sapiens_hsa053220.69642434
111Legionellosis_Homo sapiens_hsa051340.69405977
112Herpes simplex infection_Homo sapiens_hsa051680.68866738
113Pertussis_Homo sapiens_hsa051330.68757897
114African trypanosomiasis_Homo sapiens_hsa051430.68556587
115Acute myeloid leukemia_Homo sapiens_hsa052210.67805229
116Phenylalanine metabolism_Homo sapiens_hsa003600.66958748
117Apoptosis_Homo sapiens_hsa042100.66916099
118Metabolic pathways_Homo sapiens_hsa011000.66616384
119Renin-angiotensin system_Homo sapiens_hsa046140.66411202
120Huntingtons disease_Homo sapiens_hsa050160.65469533
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63311468
122Non-small cell lung cancer_Homo sapiens_hsa052230.62101453
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62077386
124Propanoate metabolism_Homo sapiens_hsa006400.61965376
125Epstein-Barr virus infection_Homo sapiens_hsa051690.61072248
126Viral myocarditis_Homo sapiens_hsa054160.60417290
127Sulfur metabolism_Homo sapiens_hsa009200.57993413
128Phagosome_Homo sapiens_hsa041450.56957889
129T cell receptor signaling pathway_Homo sapiens_hsa046600.56708017
130N-Glycan biosynthesis_Homo sapiens_hsa005100.55987789
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55702849
132Antigen processing and presentation_Homo sapiens_hsa046120.55111004
133Tyrosine metabolism_Homo sapiens_hsa003500.54386975
134Tryptophan metabolism_Homo sapiens_hsa003800.53396826
135Mineral absorption_Homo sapiens_hsa049780.53381166
136FoxO signaling pathway_Homo sapiens_hsa040680.53227625
137Other glycan degradation_Homo sapiens_hsa005110.52900212
138Fatty acid metabolism_Homo sapiens_hsa012120.52161124
139Fructose and mannose metabolism_Homo sapiens_hsa000510.51880659
140Fatty acid degradation_Homo sapiens_hsa000710.51642506
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.50448927
142Fat digestion and absorption_Homo sapiens_hsa049750.50429709
143Proteoglycans in cancer_Homo sapiens_hsa052050.49966665
144PPAR signaling pathway_Homo sapiens_hsa033200.49353343
145Leukocyte transendothelial migration_Homo sapiens_hsa046700.49189809
146HIF-1 signaling pathway_Homo sapiens_hsa040660.49058290
147Alzheimers disease_Homo sapiens_hsa050100.48764138
148Lysosome_Homo sapiens_hsa041420.48560970
149Pentose phosphate pathway_Homo sapiens_hsa000300.48474428
150Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47963114
151Prolactin signaling pathway_Homo sapiens_hsa049170.47801637
152Platelet activation_Homo sapiens_hsa046110.47773209
153Type I diabetes mellitus_Homo sapiens_hsa049400.46652232
154Bile secretion_Homo sapiens_hsa049760.46568260
155Sphingolipid signaling pathway_Homo sapiens_hsa040710.45349693
156Chemokine signaling pathway_Homo sapiens_hsa040620.44509950

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