TMED6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cobalamin metabolic process (GO:0009235)8.05197593
2transcytosis (GO:0045056)7.76286207
3regulation of type B pancreatic cell apoptotic process (GO:2000674)7.50676218
4regulation of phospholipase A2 activity (GO:0032429)7.41310300
5peptidyl-proline hydroxylation (GO:0019511)7.34889465
6intestinal absorption (GO:0050892)7.21044731
7cholesterol catabolic process (GO:0006707)6.94769268
8sterol catabolic process (GO:0016127)6.94769268
9negative regulation of digestive system process (GO:0060457)6.85697641
10cysteine metabolic process (GO:0006534)6.53239588
11glycolipid catabolic process (GO:0019377)6.51505879
12negative regulation of protein oligomerization (GO:0032460)6.25242944
13negative regulation of gluconeogenesis (GO:0045721)6.17662032
14branched-chain amino acid catabolic process (GO:0009083)6.11941005
15positive regulation of glycolytic process (GO:0045821)6.10123849
16proline biosynthetic process (GO:0006561)6.04539086
17membrane lipid catabolic process (GO:0046466)5.95675388
18valine metabolic process (GO:0006573)5.89330814
19regulation of hexokinase activity (GO:1903299)5.88564883
20regulation of glucokinase activity (GO:0033131)5.88564883
21COPI coating of Golgi vesicle (GO:0048205)5.84392670
22Golgi transport vesicle coating (GO:0048200)5.84392670
23protein hydroxylation (GO:0018126)5.65906367
24positive regulation of respiratory burst (GO:0060267)5.57411664
25fatty acid homeostasis (GO:0055089)5.43672869
26branched-chain amino acid metabolic process (GO:0009081)5.38598761
27ceramide catabolic process (GO:0046514)5.24658837
28negative regulation of acute inflammatory response (GO:0002674)5.14564709
29nitric oxide mediated signal transduction (GO:0007263)5.00268398
30cellular modified amino acid catabolic process (GO:0042219)4.92365623
31protein maturation by protein folding (GO:0022417)4.87664357
32activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.85307257
33serine family amino acid biosynthetic process (GO:0009070)4.80220835
34positive regulation of protein autophosphorylation (GO:0031954)4.79711984
35signal peptide processing (GO:0006465)4.79636174
36negative regulation of hormone biosynthetic process (GO:0032353)4.76268079
37leukotriene biosynthetic process (GO:0019370)4.74126700
38zinc ion transport (GO:0006829)4.73173893
39lactate metabolic process (GO:0006089)4.66272642
40positive regulation of nuclease activity (GO:0032075)4.64700217
41negative regulation of glycogen metabolic process (GO:0070874)4.64689391
42insulin secretion (GO:0030073)4.61190780
43mitochondrial calcium ion transport (GO:0006851)4.59985695
44positive regulation of peptide hormone secretion (GO:0090277)4.58141305
45chemosensory behavior (GO:0007635)4.56045355
46positive regulation of insulin secretion (GO:0032024)4.51526011
47response to endoplasmic reticulum stress (GO:0034976)4.50305596
48GDP-mannose metabolic process (GO:0019673)4.46519471
49negative regulation of hormone metabolic process (GO:0032351)4.45813132
50type B pancreatic cell development (GO:0003323)4.44699314
51homocysteine metabolic process (GO:0050667)4.44164370
52aspartate family amino acid catabolic process (GO:0009068)4.43353738
53intestinal epithelial cell development (GO:0060576)4.43108084
54cellular ketone body metabolic process (GO:0046950)4.40276297
55endoplasmic reticulum unfolded protein response (GO:0030968)4.39949644
56positive regulation of peptide secretion (GO:0002793)4.39286622
57maintenance of protein localization in organelle (GO:0072595)4.38419305
58neutrophil mediated immunity (GO:0002446)4.32324391
59positive regulation of heat generation (GO:0031652)4.31592237
60cellular response to unfolded protein (GO:0034620)4.30670582
614-hydroxyproline metabolic process (GO:0019471)4.28246119
62regulation of nuclease activity (GO:0032069)4.24699673
63proline metabolic process (GO:0006560)4.17843585
64positive regulation of insulin receptor signaling pathway (GO:0046628)4.17709510
65cellular response to topologically incorrect protein (GO:0035967)4.14709892
66regulation of fever generation (GO:0031620)4.13917549
67positive regulation of glycogen biosynthetic process (GO:0045725)4.06733439
68ER-nucleus signaling pathway (GO:0006984)4.03821824
69glutamine metabolic process (GO:0006541)4.00739071
70COPII vesicle coating (GO:0048208)4.00032952
71ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.98144923
72antibacterial humoral response (GO:0019731)3.91797231
73glandular epithelial cell differentiation (GO:0002067)3.90634369
74serine family amino acid metabolic process (GO:0009069)3.87456568
75positive regulation of response to nutrient levels (GO:0032109)3.87407717
76positive regulation of response to extracellular stimulus (GO:0032106)3.87407717
77L-serine metabolic process (GO:0006563)3.84518691
78ketone body metabolic process (GO:1902224)3.84289342
79positive regulation of macroautophagy (GO:0016239)3.82725506
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.81704163
81L-phenylalanine catabolic process (GO:0006559)3.81704163
82L-alpha-amino acid transmembrane transport (GO:1902475)3.79463521
83detection of calcium ion (GO:0005513)3.77783283
84ER overload response (GO:0006983)3.77726841
85inositol phosphate catabolic process (GO:0071545)3.70521645
86response to lipoprotein particle (GO:0055094)3.70355409
87creatine metabolic process (GO:0006600)3.66302241
88erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.62960936
89L-phenylalanine metabolic process (GO:0006558)3.62960936
90antimicrobial humoral response (GO:0019730)3.62785225
91positive regulation of glycogen metabolic process (GO:0070875)3.60160532
92coenzyme catabolic process (GO:0009109)3.57531322
93steroid catabolic process (GO:0006706)3.57513347
94positive regulation of nitric-oxide synthase activity (GO:0051000)3.57067683
95regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.55967499
96nucleoside diphosphate catabolic process (GO:0009134)3.54027548
97embryonic retina morphogenesis in camera-type eye (GO:0060059)3.53369699
98response to unfolded protein (GO:0006986)3.52086118
99macroautophagy (GO:0016236)3.51473216
100endocrine pancreas development (GO:0031018)3.51405988
101protein N-linked glycosylation via asparagine (GO:0018279)3.50868798
102cell redox homeostasis (GO:0045454)3.49206095
103xenobiotic catabolic process (GO:0042178)3.48863407
104peptidyl-asparagine modification (GO:0018196)3.48543061
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.48447705
106regulation of insulin secretion (GO:0050796)3.48236757
107arachidonic acid secretion (GO:0050482)3.46101364
108icosanoid secretion (GO:0032309)3.46101364
109positive regulation of hormone secretion (GO:0046887)3.43766756
110positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.42264155
111response to topologically incorrect protein (GO:0035966)3.41868264
112sulfur amino acid biosynthetic process (GO:0000097)3.39263909
113cellular zinc ion homeostasis (GO:0006882)3.38582763
114negative regulation of epidermal cell differentiation (GO:0045605)3.37399500
115sphingolipid catabolic process (GO:0030149)3.37228457
116glycerophospholipid catabolic process (GO:0046475)3.37008204
117biotin metabolic process (GO:0006768)3.35790985
118glycine metabolic process (GO:0006544)3.30049949
119regulation of heat generation (GO:0031650)3.28383360
120myeloid leukocyte mediated immunity (GO:0002444)3.27047126
121mitochondrion distribution (GO:0048311)3.24642735
122regulation of peptide hormone secretion (GO:0090276)3.23558665
123inositol phosphate dephosphorylation (GO:0046855)3.23402549
124phosphorylated carbohydrate dephosphorylation (GO:0046838)3.23402549
125retinal metabolic process (GO:0042574)3.23338411
126polyol catabolic process (GO:0046174)3.22914658
127zinc ion homeostasis (GO:0055069)3.21185851
128protein N-linked glycosylation (GO:0006487)3.21095644
129peptide hormone processing (GO:0016486)3.20982605
130regulation of glycolytic process (GO:0006110)3.20250539
131respiratory chain complex IV assembly (GO:0008535)3.19797335
132regulation of protein glycosylation (GO:0060049)3.17420691
133regulation of peptide secretion (GO:0002791)3.15282443
134peptide hormone secretion (GO:0030072)3.14217646
135positive regulation of vasodilation (GO:0045909)3.14073359
136alpha-amino acid biosynthetic process (GO:1901607)3.12242207
137negative regulation of neurological system process (GO:0031645)3.10898876
138regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)3.10749622
139phenylpropanoid metabolic process (GO:0009698)3.09728412
140glandular epithelial cell development (GO:0002068)3.09617712
141water-soluble vitamin biosynthetic process (GO:0042364)3.08724533
142regulation of energy homeostasis (GO:2000505)3.08406583
143response to glucose (GO:0009749)3.05932980
144response to hepatocyte growth factor (GO:0035728)3.05527348
145cellular response to hepatocyte growth factor stimulus (GO:0035729)3.05527348
146cellular response to vitamin D (GO:0071305)3.04753995
147phosphatidylinositol acyl-chain remodeling (GO:0036149)3.02712389
148zinc ion transmembrane transport (GO:0071577)3.01615529
149peptide secretion (GO:0002790)3.00312498
150nucleotide-sugar biosynthetic process (GO:0009226)3.00228728
151cellular protein catabolic process (GO:0044257)2.99668974
152innate immune response in mucosa (GO:0002227)2.99219917
153regulation of protein autophosphorylation (GO:0031952)2.97306044
154keratinocyte development (GO:0003334)2.96092735
155regulation of oxidative stress-induced cell death (GO:1903201)2.96080999
156sulfur amino acid catabolic process (GO:0000098)2.94983304
157regulation of glucocorticoid metabolic process (GO:0031943)2.94461518
158peptidyl-proline modification (GO:0018208)2.94443002
159phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.93876360
160response to hexose (GO:0009746)2.92083589
161aspartate family amino acid metabolic process (GO:0009066)2.91850337
162peptide catabolic process (GO:0043171)2.90313950
163digestive system process (GO:0022600)2.89614534
164regulation of steroid hormone biosynthetic process (GO:0090030)2.88750710
165regulation of autophagic vacuole assembly (GO:2000785)2.88601851
166lysine catabolic process (GO:0006554)2.88246890
167lysine metabolic process (GO:0006553)2.88246890
168regulation of digestive system process (GO:0044058)2.86552948
169regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.85267859
170regulation of hormone secretion (GO:0046883)2.82324917
171positive regulation of cellular response to insulin stimulus (GO:1900078)2.81763633
172epithelial cell fate commitment (GO:0072148)2.76796828
173cellular response to zinc ion (GO:0071294)2.75629011
174response to monosaccharide (GO:0034284)2.75498699
175regulation of vacuole organization (GO:0044088)2.74449688
176regulation of respiratory burst (GO:0060263)2.71654671
177regulation of acrosome reaction (GO:0060046)2.68742210
178hormone secretion (GO:0046879)2.63964294
179negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.63260949
180kidney morphogenesis (GO:0060993)2.62408916
181regulation of oxidative phosphorylation (GO:0002082)2.61850753
182intestinal cholesterol absorption (GO:0030299)16.1377979
183exocrine pancreas development (GO:0031017)15.7685929
184digestion (GO:0007586)13.7730311
185protein retention in ER lumen (GO:0006621)12.6221946
186maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.8905216

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.17247086
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.00050495
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.87466180
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.61776712
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.45943538
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.10033487
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.69418710
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69267805
9PPARA_22158963_ChIP-Seq_LIVER_Mouse2.67716125
10GATA4_25053715_ChIP-Seq_YYC3_Human2.61542728
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.57736431
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.51768660
13CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.44172667
14ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.38447061
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35580823
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35580823
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35580823
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.32086862
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.28864668
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.15147735
21LXR_22158963_ChIP-Seq_LIVER_Mouse2.12547166
22PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.11827685
23GATA6_25053715_ChIP-Seq_YYC3_Human2.03972977
24TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03006642
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.01833281
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.00536454
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.97881922
28GBX2_23144817_ChIP-Seq_PC3_Human1.89522276
29IGF1R_20145208_ChIP-Seq_DFB_Human1.84028124
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.81059913
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.79331799
32HTT_18923047_ChIP-ChIP_STHdh_Human1.78363158
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.76513504
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.74865464
35HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.71599014
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.70534909
37EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.68100806
38EGR1_23403033_ChIP-Seq_LIVER_Mouse1.67930256
39NOTCH1_21737748_ChIP-Seq_TLL_Human1.64113032
40CDX2_22108803_ChIP-Seq_LS180_Human1.62828618
41TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59940950
42PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.58858219
43BCAT_22108803_ChIP-Seq_LS180_Human1.58767349
44ER_23166858_ChIP-Seq_MCF-7_Human1.57195430
45E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.54600949
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.54093851
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51305128
48E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.50203954
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.49258565
50EGR1_19032775_ChIP-ChIP_M12_Human1.45382227
51TFEB_21752829_ChIP-Seq_HELA_Human1.42722562
52SMAD4_21799915_ChIP-Seq_A2780_Human1.42287356
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.41736506
54TP53_22573176_ChIP-Seq_HFKS_Human1.41497580
55AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41109744
56GATA1_22025678_ChIP-Seq_K562_Human1.40422973
57NANOG_18555785_Chip-Seq_ESCs_Mouse1.37637425
58AR_25329375_ChIP-Seq_VCAP_Human1.37432442
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36539640
60CBP_20019798_ChIP-Seq_JUKART_Human1.36539640
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36224272
62P300_19829295_ChIP-Seq_ESCs_Human1.36047536
63PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.35385669
64FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.34493920
65CHD1_26751641_Chip-Seq_LNCaP_Human1.34399375
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.32585831
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.31879614
68FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30064871
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.29127087
70ESET_19884257_ChIP-Seq_ESCs_Mouse1.28685643
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28216091
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.27142084
73SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25613819
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24631049
75ETS1_20019798_ChIP-Seq_JURKAT_Human1.23962411
76BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23090800
77ERG_20517297_ChIP-Seq_VCAP_Human1.22715319
78HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22210700
79RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22154392
80ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.21951053
81HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21477721
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.21087843
83ERA_21632823_ChIP-Seq_H3396_Human1.20954551
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.19606013
85FUS_26573619_Chip-Seq_HEK293_Human1.19484314
86MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19041524
87TAF15_26573619_Chip-Seq_HEK293_Human1.18915347
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18702409
89ETS1_21867929_ChIP-Seq_TH2_Mouse1.18398220
90SOX2_19829295_ChIP-Seq_ESCs_Human1.18355329
91NANOG_19829295_ChIP-Seq_ESCs_Human1.18355329
92CMYC_18555785_Chip-Seq_ESCs_Mouse1.18206261
93P53_21459846_ChIP-Seq_SAOS-2_Human1.18019660
94TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.17017214
95CTBP1_25329375_ChIP-Seq_LNCAP_Human1.16967813
96NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.16381582
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15830589
98P53_22387025_ChIP-Seq_ESCs_Mouse1.13489754
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13385813
100CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13367196
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13345186
102OCT4_20526341_ChIP-Seq_ESCs_Human1.13315067
103SOX2_18555785_Chip-Seq_ESCs_Mouse1.12796242
104CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11336053
105SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.10556489
106ELK4_26923725_Chip-Seq_MESODERM_Mouse1.10088099
107STAT3_18555785_Chip-Seq_ESCs_Mouse1.09991219
108* P68_20966046_ChIP-Seq_HELA_Human1.09989784
109STAT3_23295773_ChIP-Seq_U87_Human1.08819611
110CTCF_18555785_Chip-Seq_ESCs_Mouse1.08660021
111ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08279895
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07911441
113FOXA1_27270436_Chip-Seq_PROSTATE_Human1.07620195
114FOXA1_25329375_ChIP-Seq_VCAP_Human1.07620195
115CREB1_26743006_Chip-Seq_LNCaP_Human1.07524663
116BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06827073
117SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06302975
118* SA1_27219007_Chip-Seq_ERYTHROID_Human1.05152320
119TCF4_22108803_ChIP-Seq_LS180_Human1.05131411
120FOXA1_25552417_ChIP-Seq_VCAP_Human1.04579313
121TAF2_19829295_ChIP-Seq_ESCs_Human1.04283723
122SMAD4_21741376_ChIP-Seq_EPCs_Human1.04203489
123SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04187048
124ATF3_27146783_Chip-Seq_COLON_Human1.03792467
125LXR_22292898_ChIP-Seq_THP-1_Human1.03773724
126JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03701612
127CBP_21632823_ChIP-Seq_H3396_Human1.03199917
128P300_18555785_Chip-Seq_ESCs_Mouse1.03065708
129* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03038733
130IRF1_19129219_ChIP-ChIP_H3396_Human1.02851214
131AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.01309742
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.00918746
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00880857
134PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.00826255
135TP63_22573176_ChIP-Seq_HFKS_Human1.00779218
136E2F1_18555785_Chip-Seq_ESCs_Mouse1.00485192
137* NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99952251
138SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.99555821
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.99203372
140KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99187622
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.99076006
142CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98997498
143EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.98919584
144EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98524560
145NMYC_18555785_Chip-Seq_ESCs_Mouse0.98419939
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.97843428
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.97795847
148PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.97727576
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97611891
150SOX2_20726797_ChIP-Seq_SW620_Human0.97525268
151PHF8_20622853_ChIP-Seq_HELA_Human0.96830225
152SMAD3_21741376_ChIP-Seq_EPCs_Human0.96675844
153ZFX_18555785_Chip-Seq_ESCs_Mouse0.96488606
154NCOR_22424771_ChIP-Seq_293T_Human0.96454577
155SOX2_22085726_ChIP-Seq_NPCs_Mouse0.95620704
156VDR_22108803_ChIP-Seq_LS180_Human0.95521231
157FOXP1_21924763_ChIP-Seq_HESCs_Human0.94903763
158PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91391830
159CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.90722158
160RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90719341
161CTCF_20526341_ChIP-Seq_ESCs_Human0.90024078
162RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89868128
163NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.88861177
164ZNF274_21170338_ChIP-Seq_K562_Hela0.88043533
165FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87799602
166* FOXH1_21741376_ChIP-Seq_ESCs_Human0.87640194
167SA1_27219007_Chip-Seq_Bcells_Human0.86555272
168SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.86131123
169GATA3_24758297_ChIP-Seq_MCF-7_Human0.85847906
170GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.85808742
171* BCOR_27268052_Chip-Seq_Bcells_Human0.85387060
172RARA_24833708_ChIP-Seq_LIVER_Mouse0.84983214
173RUNX1_27514584_Chip-Seq_MCF-7_Human0.84202315
174CTCF_18555785_ChIP-Seq_MESCs_Mouse0.83493086
175MYC_18358816_ChIP-ChIP_MESCs_Mouse0.83185893
176CEBPB_22108803_ChIP-Seq_LS180_Human0.83060166
177FOXA2_19822575_ChIP-Seq_HepG2_Human0.82894036
178SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.82587162
179FLI1_21867929_ChIP-Seq_CD8_Mouse0.81581609
180SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.81199709
181AR_20517297_ChIP-Seq_VCAP_Human0.80381437
182TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.80283088

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.53602448
2MP0001666_abnormal_nutrient_absorption9.30596843
3MP0005365_abnormal_bile_salt6.68060310
4MP0005220_abnormal_exocrine_pancreas6.50883185
5MP0003868_abnormal_feces_composition4.91347248
6MP0005084_abnormal_gallbladder_morpholo4.65986954
7MP0003787_abnormal_imprinting4.08404287
8MP0005085_abnormal_gallbladder_physiolo3.61303967
9MP0002163_abnormal_gland_morphology3.13489643
10MP0002837_dystrophic_cardiac_calcinosis3.07060231
11MP0005379_endocrine/exocrine_gland_phen3.00113444
12MP0003122_maternal_imprinting2.97102996
13MP0001664_abnormal_digestion2.92713078
14MP0003123_paternal_imprinting2.86442254
15MP0002909_abnormal_adrenal_gland2.73898661
16MP0002693_abnormal_pancreas_physiology2.73013785
17MP0008004_abnormal_stomach_pH2.50985304
18MP0003959_abnormal_lean_body2.50586267
19MP0008877_abnormal_DNA_methylation2.36080001
20MP0002139_abnormal_hepatobiliary_system1.95834972
21MP0005645_abnormal_hypothalamus_physiol1.86837756
22MP0002090_abnormal_vision1.85805361
23MP0001944_abnormal_pancreas_morphology1.82412786
24MP0004264_abnormal_extraembryonic_tissu1.81495285
25MP0003172_abnormal_lysosome_physiology1.74290859
26MP0006072_abnormal_retinal_apoptosis1.65604075
27MP0005448_abnormal_energy_balance1.61645910
28MP0004233_abnormal_muscle_weight1.61321143
29MP0003121_genomic_imprinting1.60894711
30MP0003705_abnormal_hypodermis_morpholog1.54183993
31MP0005451_abnormal_body_composition1.52903665
32MP0005332_abnormal_amino_acid1.52649816
33MP0002277_abnormal_respiratory_mucosa1.49307801
34MP0004019_abnormal_vitamin_homeostasis1.45400967
35MP0002118_abnormal_lipid_homeostasis1.42277702
36MP0003638_abnormal_response/metabolism_1.38139613
37MP0000462_abnormal_digestive_system1.35200021
38MP0009046_muscle_twitch1.33029181
39MP0001984_abnormal_olfaction1.28522661
40MP0000470_abnormal_stomach_morphology1.27535578
41MP0009840_abnormal_foam_cell1.25465980
42MP0001873_stomach_inflammation1.23560424
43MP0003879_abnormal_hair_cell1.23473563
44MP0010234_abnormal_vibrissa_follicle1.22705198
45MP0002102_abnormal_ear_morphology1.22319454
46MP0005551_abnormal_eye_electrophysiolog1.18158356
47MP0005646_abnormal_pituitary_gland1.17509357
48MP0003011_delayed_dark_adaptation1.12401230
49MP0005165_increased_susceptibility_to1.11968241
50MP0003806_abnormal_nucleotide_metabolis1.09939217
51MP0005408_hypopigmentation1.09319727
52MP0002078_abnormal_glucose_homeostasis1.06788147
53MP0009643_abnormal_urine_homeostasis1.04518745
54MP0000427_abnormal_hair_cycle1.03087284
55MP0002166_altered_tumor_susceptibility0.96932541
56MP0000003_abnormal_adipose_tissue0.96821448
57MP0000516_abnormal_urinary_system0.94281429
58MP0005367_renal/urinary_system_phenotyp0.94281429
59MP0005058_abnormal_lysosome_morphology0.94221631
60MP0000490_abnormal_crypts_of0.91812814
61MP0005535_abnormal_body_temperature0.88771328
62MP0001764_abnormal_homeostasis0.84003773
63MP0003252_abnormal_bile_duct0.83583059
64MP0009384_cardiac_valve_regurgitation0.83571811
65MP0002971_abnormal_brown_adipose0.82745138
66MP0003953_abnormal_hormone_level0.82173813
67MP0010352_gastrointestinal_tract_polyps0.79244440
68MP0002638_abnormal_pupillary_reflex0.79023957
69MP0001986_abnormal_taste_sensitivity0.78922154
70MP0002160_abnormal_reproductive_system0.78746401
71MP0001727_abnormal_embryo_implantation0.78670730
72MP0003186_abnormal_redox_activity0.78404619
73MP0006036_abnormal_mitochondrial_physio0.78071988
74MP0005360_urolithiasis0.77697702
75MP0002138_abnormal_hepatobiliary_system0.74987798
76MP0004270_analgesia0.73609008
77MP0005174_abnormal_tail_pigmentation0.71340542
78MP0004924_abnormal_behavior0.71114509
79MP0005386_behavior/neurological_phenoty0.71114509
80MP0008438_abnormal_cutaneous_collagen0.70799344
81MP0000569_abnormal_digit_pigmentation0.70673456
82MP0010329_abnormal_lipoprotein_level0.70324063
83MP0005253_abnormal_eye_physiology0.69528982
84MP0005389_reproductive_system_phenotype0.68891581
85MP0010678_abnormal_skin_adnexa0.68719230
86MP0001663_abnormal_digestive_system0.68237198
87MP0005452_abnormal_adipose_tissue0.68096936
88MP0001502_abnormal_circadian_rhythm0.67135960
89MP0002132_abnormal_respiratory_system0.66766961
90MP0006054_spinal_hemorrhage0.66519386
91MP0003633_abnormal_nervous_system0.66148915
92MP0004043_abnormal_pH_regulation0.64538629
93MP0002938_white_spotting0.64070272
94MP0002876_abnormal_thyroid_physiology0.63033097
95MP0008789_abnormal_olfactory_epithelium0.62257716
96MP0002557_abnormal_social/conspecific_i0.62079569
97MP0002272_abnormal_nervous_system0.61639433
98MP0004885_abnormal_endolymph0.61205993
99MP0000613_abnormal_salivary_gland0.60046468
100MP0004134_abnormal_chest_morphology0.59753725
101MP0000639_abnormal_adrenal_gland0.58961225
102MP0005266_abnormal_metabolism0.57648702
103MP0003567_abnormal_fetal_cardiomyocyte0.57184757
104MP0000598_abnormal_liver_morphology0.57046822
105MP0008961_abnormal_basal_metabolism0.55382833
106MP0009765_abnormal_xenobiotic_induced0.53620108
107MP0005381_digestive/alimentary_phenotyp0.53593534
108MP0005319_abnormal_enzyme/_coenzyme0.52633628
109MP0000609_abnormal_liver_physiology0.52144040
110MP0002928_abnormal_bile_duct0.50004424
111MP0005375_adipose_tissue_phenotype0.49284832
112MP0002098_abnormal_vibrissa_morphology0.48395263
113MP0001731_abnormal_postnatal_growth0.46232571
114MP0001845_abnormal_inflammatory_respons0.45833622
115MP0005636_abnormal_mineral_homeostasis0.45567128
116MP0000750_abnormal_muscle_regeneration0.44872825
117MP0005334_abnormal_fat_pad0.41395025
118MP0001756_abnormal_urination0.41140942
119MP0002089_abnormal_postnatal_growth/wei0.40685623
120MP0005394_taste/olfaction_phenotype0.40385974
121MP0005499_abnormal_olfactory_system0.40385974
122MP0003795_abnormal_bone_structure0.39113334
123MP0003183_abnormal_peptide_metabolism0.38452340
124MP0003656_abnormal_erythrocyte_physiolo0.38224575
125MP0000367_abnormal_coat/_hair0.38114070
126MP0000371_diluted_coat_color0.37747983
127MP0004185_abnormal_adipocyte_glucose0.37361178
128MP0009642_abnormal_blood_homeostasis0.36112763
129MP0002060_abnormal_skin_morphology0.35561271
130MP0010386_abnormal_urinary_bladder0.35429732
131MP0002796_impaired_skin_barrier0.35354732
132MP0001765_abnormal_ion_homeostasis0.33522319
133MP0000377_abnormal_hair_follicle0.32169540
134MP0000013_abnormal_adipose_tissue0.32016411
135MP0009333_abnormal_splenocyte_physiolog0.30962299
136MP0003283_abnormal_digestive_organ0.29017309
137MP0002069_abnormal_eating/drinking_beha0.28776304
138MP0003195_calcinosis0.28113797
139MP0008872_abnormal_physiological_respon0.27816766
140MP0001348_abnormal_lacrimal_gland0.26270324
141MP0000647_abnormal_sebaceous_gland0.25212668
142MP0008469_abnormal_protein_level0.23344774
143MP0003956_abnormal_body_size0.23126186
144MP0003329_amyloid_beta_deposits0.22799154
145MP0003693_abnormal_embryo_hatching0.21513182
146MP0002970_abnormal_white_adipose0.21218917
147MP0006035_abnormal_mitochondrial_morpho0.19469340
148MP0000358_abnormal_cell_content/0.19203179
149MP0009780_abnormal_chondrocyte_physiolo0.19121197
150MP0001186_pigmentation_phenotype0.18660151
151MP0008875_abnormal_xenobiotic_pharmacok0.17659167
152MP0001661_extended_life_span0.17176791

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.91484288
2Gout (HP:0001997)6.68592510
3Fat malabsorption (HP:0002630)6.59824089
4Short chin (HP:0000331)6.05256378
5Symptomatic seizures (HP:0011145)6.04856138
6Decreased subcutaneous fat (HP:0001002)5.86538343
7Abnormality of subcutaneous fat tissue (HP:0001001)5.33788725
8Type I diabetes mellitus (HP:0100651)5.28200867
9Hypomagnesemia (HP:0002917)5.07339926
10Abnormality of the intrinsic pathway (HP:0010989)5.07273442
11Maternal diabetes (HP:0009800)4.63575500
12Exocrine pancreatic insufficiency (HP:0001738)4.58529999
13Pancreatic islet-cell hyperplasia (HP:0004510)4.50672794
14Large for gestational age (HP:0001520)4.49548359
15Prominent metopic ridge (HP:0005487)4.48574338
16Hypoplasia of the pons (HP:0012110)4.40280376
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.39021433
18Insulin-resistant diabetes mellitus (HP:0000831)4.24723180
19Abnormality of aromatic amino acid family metabolism (HP:0004338)4.24395430
20Abnormality of the pons (HP:0007361)4.17747796
21Abnormality of magnesium homeostasis (HP:0004921)4.10695515
22Hyperglycinemia (HP:0002154)4.01324215
23Abnormality of the metopic suture (HP:0005556)3.96899793
24Increased circulating renin level (HP:0000848)3.95166377
25Tubulointerstitial nephritis (HP:0001970)3.94693812
26Ketosis (HP:0001946)3.91336191
27Pancreatitis (HP:0001733)3.87326289
28Ketoacidosis (HP:0001993)3.73562799
29Joint stiffness (HP:0001387)3.68459147
30Hypothermia (HP:0002045)3.66358977
31Premature skin wrinkling (HP:0100678)3.63421450
32Abnormal pancreas size (HP:0012094)3.62763826
33Hyperglycinuria (HP:0003108)3.56792528
34Cortical dysplasia (HP:0002539)3.56481565
35Carpal bone hypoplasia (HP:0001498)3.51033708
36EEG with generalized epileptiform discharges (HP:0011198)3.44318080
37Epileptiform EEG discharges (HP:0011182)3.34298367
38Abnormality of serine family amino acid metabolism (HP:0010894)3.29052587
39Abnormality of glycine metabolism (HP:0010895)3.29052587
40Hypsarrhythmia (HP:0002521)3.26189268
41Enlarged penis (HP:0000040)3.24698911
42Hyperuricemia (HP:0002149)3.20153594
43Increased purine levels (HP:0004368)3.20153594
44Long foot (HP:0001833)3.19218585
45Tubulointerstitial fibrosis (HP:0005576)3.13420094
46Abnormal protein glycosylation (HP:0012346)3.11455335
47Abnormal glycosylation (HP:0012345)3.11455335
48Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.11455335
49Abnormal protein N-linked glycosylation (HP:0012347)3.11455335
50Hypoglycemic coma (HP:0001325)3.07542467
51Hypoproteinemia (HP:0003075)3.02663174
52Abnormality of sulfur amino acid metabolism (HP:0004339)3.00188255
53Vacuolated lymphocytes (HP:0001922)2.98950362
54Hypokinesia (HP:0002375)2.95137711
55Hyperphosphatemia (HP:0002905)2.93677562
56Abnormality of endocrine pancreas physiology (HP:0012093)2.91081940
57Abnormality of the pancreatic islet cells (HP:0006476)2.91081940
58Optic nerve hypoplasia (HP:0000609)2.77894524
59Hypobetalipoproteinemia (HP:0003563)2.77701580
60Abnormality of the common coagulation pathway (HP:0010990)2.76611364
61Progressive muscle weakness (HP:0003323)2.74385662
62Prenatal maternal abnormality (HP:0002686)2.67511494
63Sex reversal (HP:0012245)2.66163722
64Abnormal sex determination (HP:0012244)2.66163722
65Insulin resistance (HP:0000855)2.63157376
66Megaloblastic anemia (HP:0001889)2.60185740
67Reduced antithrombin III activity (HP:0001976)2.57704653
68Abnormal number of erythroid precursors (HP:0012131)2.57578847
69Hypoglycemic seizures (HP:0002173)2.55626591
70Retinal atrophy (HP:0001105)2.54183711
71Methylmalonic aciduria (HP:0012120)2.52988525
72Abnormal tarsal ossification (HP:0008369)2.49726551
73Abnormality of cells of the erythroid lineage (HP:0012130)2.48867939
74Hyperthyroidism (HP:0000836)2.45211696
75Prolonged partial thromboplastin time (HP:0003645)2.43555611
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.42973778
77Dysostosis multiplex (HP:0000943)2.39534944
78Acute hepatic failure (HP:0006554)2.39503409
79Neoplasm of the adrenal cortex (HP:0100641)2.39497079
80Fatigue (HP:0012378)2.38707315
81Tubular atrophy (HP:0000092)2.38511146
82Testicular neoplasm (HP:0010788)2.37295815
83Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.35016864
84Muscular hypotonia of the trunk (HP:0008936)2.30331107
85Polydipsia (HP:0001959)2.29331557
86Abnormal drinking behavior (HP:0030082)2.29331557
87Pectus carinatum (HP:0000768)2.28996329
88Renal salt wasting (HP:0000127)2.28857613
89Abnormality of methionine metabolism (HP:0010901)2.27278441
90Tongue fasciculations (HP:0001308)2.26934417
91Hypoplasia of the odontoid process (HP:0003311)2.26629440
92Abnormality of purine metabolism (HP:0004352)2.23410100
93Tetany (HP:0001281)2.20810682
94Small epiphyses (HP:0010585)2.20322583
95Acute encephalopathy (HP:0006846)2.19912946
96Dicarboxylic aciduria (HP:0003215)2.17644705
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.17644705
98Opisthotonus (HP:0002179)2.17091783
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.16156504
100Downturned corners of mouth (HP:0002714)2.15915763
101Late onset (HP:0003584)2.15742473
102Hyperinsulinemic hypoglycemia (HP:0000825)2.15643624
103Cortical visual impairment (HP:0100704)2.13001683
104Abnormality of homocysteine metabolism (HP:0010919)2.12540609
105Homocystinuria (HP:0002156)2.12540609
106Lethargy (HP:0001254)2.11286671
107Type I transferrin isoform profile (HP:0003642)2.09908568
108Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09894896
109Ventricular fibrillation (HP:0001663)2.08675157
110Hematochezia (HP:0002573)2.07846089
111Congenital malformation of the right heart (HP:0011723)2.07401226
112Double outlet right ventricle (HP:0001719)2.07401226
113Beaking of vertebral bodies (HP:0004568)2.07150753
114Methylmalonic acidemia (HP:0002912)2.06016297
115Diminished movement (HP:0002374)2.04212930
116Conjunctival hamartoma (HP:0100780)2.03326938
117Abnormality of the renal cortex (HP:0011035)2.03233323
118Hyperammonemia (HP:0001987)2.03036178
119Congenital glaucoma (HP:0001087)2.02467199
120Hyperphosphaturia (HP:0003109)2.01786385
121Barrel-shaped chest (HP:0001552)2.01685292
122Type II lissencephaly (HP:0007260)2.01046356
123Abnormality of fatty-acid metabolism (HP:0004359)1.99687774
124Cerebral edema (HP:0002181)1.98682946
125Lower limb hyperreflexia (HP:0002395)1.96829455
126Limb hypertonia (HP:0002509)1.96647136
127Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95712632
128Hepatic necrosis (HP:0002605)1.94267637
129Abnormality of renin-angiotensin system (HP:0000847)1.91710060
130Myocardial infarction (HP:0001658)1.91331180
131Hyperglycemia (HP:0003074)1.90858268
132Tubulointerstitial abnormality (HP:0001969)1.90195760
133Large hands (HP:0001176)1.89944310
134Abnormality of serum amino acid levels (HP:0003112)1.89226063
135Glycosuria (HP:0003076)1.87592420
136Abnormality of urine glucose concentration (HP:0011016)1.87592420
137Tachypnea (HP:0002789)1.86999234
138Abnormality of the vitamin B12 metabolism (HP:0004341)1.86725022
139Muscle fibrillation (HP:0010546)1.86150970
140Abnormality of renal excretion (HP:0011036)1.85787945
141Calf muscle hypertrophy (HP:0008981)1.85549053
142Redundant skin (HP:0001582)1.84846974
143Vascular calcification (HP:0004934)1.84566198
144Agitation (HP:0000713)1.84292234
145Hypoplasia of the uterus (HP:0000013)1.84235759
146Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.83725072
147Thoracic kyphosis (HP:0002942)1.83466034
148Basal ganglia calcification (HP:0002135)1.83067289
149Abnormality of vitamin B metabolism (HP:0004340)1.82648854
150Abnormality of the basal ganglia (HP:0002134)1.82263960
151Unilateral renal agenesis (HP:0000122)1.80426141
152Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79557997
153Hamartoma of the eye (HP:0010568)1.72664623
154Albinism (HP:0001022)1.71155452
155Small for gestational age (HP:0001518)1.69268446
156Progressive macrocephaly (HP:0004481)1.66572372
157Xanthomatosis (HP:0000991)1.66514783
158Abnormality of vitamin metabolism (HP:0100508)1.66122954
159Cardiovascular calcification (HP:0011915)1.62566218
160Malnutrition (HP:0004395)1.62486276
161Progressive neurologic deterioration (HP:0002344)1.62364521
162Polyuria (HP:0000103)1.61660346
163Adrenal hypoplasia (HP:0000835)1.61181946
164Hemiparesis (HP:0001269)1.59479250
165Progressive hearing impairment (HP:0001730)1.57810398
166Abnormal urine phosphate concentration (HP:0012599)1.57645602
167Abnormal biliary tract morphology (HP:0012440)1.56438841
168Polyphagia (HP:0002591)1.56198605
169Poor suck (HP:0002033)1.55590967
170Muscle hypertrophy of the lower extremities (HP:0008968)1.55319965
171Septate vagina (HP:0001153)1.46138087
172Episodic fever (HP:0001954)1.45483636
173Nuclear cataract (HP:0100018)1.44700881
174Bilateral sensorineural hearing impairment (HP:0008619)1.44382252
175Menstrual irregularities (HP:0000858)1.43717781
176Increased CSF protein (HP:0002922)1.43699376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.45338841
2EIF2AK34.62493582
3FGFR24.26617532
4MAP2K23.84893523
5TRIB33.14804101
6PKN22.73132582
7MST42.68872728
8FRK2.57548403
9FGFR32.54412826
10INSRR2.54095016
11IRAK32.15629291
12MAPKAPK32.14922963
13WNK42.01442940
14BCKDK10.3467774
15ZAP701.96985038
16NTRK31.95886186
17AKT31.81418827
18NLK1.77933192
19PHKG21.63111398
20PHKG11.63111398
21NME11.62624247
22NME21.60642206
23MAP2K11.52913461
24PAK21.51459267
25HIPK21.44632269
26SCYL21.44037174
27ADRBK21.42973137
28PAK31.40625395
29MAP3K121.40348025
30PDK21.33945836
31TRIM281.31536488
32TAOK31.30790440
33PIK3CG1.26967439
34PRKAA21.25285803
35GRK11.25223221
36STK31.20856518
37DYRK1A1.19332651
38TAOK11.16207191
39TRPM71.15597706
40ACVR1B1.14129445
41FLT31.10043694
42RPS6KB21.09282090
43EEF2K1.09148867
44PDGFRB1.05967898
45PIK3CA1.01575115
46BMPR1B0.97809141
47MAPK150.96734991
48STK390.94745040
49PTK60.93303091
50MAP3K40.92388315
51PDK30.92265328
52PDK40.92265328
53TNIK0.91363924
54LATS10.89677839
55PRKCE0.88726619
56CAMK1G0.88433620
57PRKCG0.87537160
58STK160.86345063
59IRAK20.85436376
60CAMK2D0.83960433
61CSNK1G10.82697285
62ERBB30.77256575
63CAMKK10.76189907
64MAP4K20.74350524
65MAP2K60.73799057
66STK240.72883911
67PNCK0.70986746
68BCR0.67976537
69STK110.61777735
70PRKCI0.61712935
71IRAK40.61265117
72SGK20.59566720
73MTOR0.59346116
74PINK10.57529813
75SIK10.56938923
76PDPK10.56834706
77RPS6KB10.56517830
78DYRK1B0.56169670
79CSNK1G30.55974264
80MAP3K20.55144798
81DAPK20.54947993
82TSSK60.54876067
83MYLK0.54042560
84CAMKK20.52942982
85TIE10.51174408
86PDK10.50972627
87PLK30.50215270
88CDK30.50133236
89NEK60.49948824
90ZAK0.48651292
91MST1R0.45776419
92CAMK1D0.45545226
93YES10.45425969
94RET0.44579109
95SGK4940.44377449
96SGK2230.44377449
97TGFBR20.43984595
98PRKCZ0.43912005
99IRAK10.43746416
100DAPK10.41142152
101MAPK120.40179464
102CSNK1A1L0.40130149
103DYRK20.38644864
104LRRK20.38218991
105CSNK1D0.37829399
106ADRBK10.36403892
107CSNK1G20.35912108
108SGK30.34674012
109OBSCN0.32212969
110FGFR40.31727093
111PRKG10.31561353
112MAPK30.31092311
113LIMK10.30518293
114PRKACB0.30282934
115EIF2AK10.29386173
116MKNK20.29288653
117MET0.28963519
118SGK10.27885347
119JAK10.27663589
120PRKCH0.27346627
121PRKCA0.26823077
122NUAK10.26719968
123PLK20.26217682
124MAP3K30.25648494
125BRAF0.25392172
126CASK0.25192113
127NTRK10.24664041
128IKBKB0.22845588
129RPS6KA10.22663164
130STK38L0.22620235
131PASK0.22103983
132ATM0.22038804
133PRKG20.21889473
134MAP2K70.21829961
135KSR20.20229289
136FER0.18991731
137MAPK110.18640143
138PRKAA10.18349345
139ABL10.17335407
140JAK20.17145650
141PRKD30.16669103
142PIM20.16039337
143STK380.15453669
144MAP3K90.15247956
145IGF1R0.13946399
146MAP3K80.13443282
147EPHA30.13052884
148CSNK1A10.12936876
149ILK0.12669104
150MAPK10.11220380
151WNK10.10425066
152BRSK20.10270973
153AKT10.08879995
154CSNK1E0.06703838
155GSK3A0.06503564
156EGFR0.06406439
157PRKD10.06256271
158PRKACA0.05876383
159CDK190.05319052
160MAP3K70.05285511
161WNK30.04960717
162PTK20.04073098
163CDK40.04007400
164MAP2K40.03510375
165MAP3K10.03494009
166DDR20.03092683
167TBK10.02432220

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049727.78461918
2Fat digestion and absorption_Homo sapiens_hsa049755.83763505
3Protein digestion and absorption_Homo sapiens_hsa049745.11015000
4Protein export_Homo sapiens_hsa030603.84915496
5Folate biosynthesis_Homo sapiens_hsa007903.24226183
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.09083620
7Glycerolipid metabolism_Homo sapiens_hsa005612.93284812
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.75571004
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.67194063
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38483600
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37549084
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.36425905
13Vitamin digestion and absorption_Homo sapiens_hsa049772.29046132
14Type II diabetes mellitus_Homo sapiens_hsa049302.26384670
15Fatty acid elongation_Homo sapiens_hsa000622.16382139
16Propanoate metabolism_Homo sapiens_hsa006402.05837092
17Type I diabetes mellitus_Homo sapiens_hsa049401.81374195
18Steroid biosynthesis_Homo sapiens_hsa001001.71947011
19alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.45625519
20Linoleic acid metabolism_Homo sapiens_hsa005911.39061384
21Circadian rhythm_Homo sapiens_hsa047101.38608128
22Renin-angiotensin system_Homo sapiens_hsa046141.38604910
23Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37514118
24Mineral absorption_Homo sapiens_hsa049781.33429460
25Arginine and proline metabolism_Homo sapiens_hsa003301.33394311
262-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20992269
27Other glycan degradation_Homo sapiens_hsa005111.14929103
28Biosynthesis of amino acids_Homo sapiens_hsa012301.10762020
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.09831930
30N-Glycan biosynthesis_Homo sapiens_hsa005101.08614087
31Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06690952
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.00897380
33Ovarian steroidogenesis_Homo sapiens_hsa049130.98815498
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98369009
35Selenocompound metabolism_Homo sapiens_hsa004500.97776329
36Cysteine and methionine metabolism_Homo sapiens_hsa002700.96985419
37Sulfur metabolism_Homo sapiens_hsa009200.93312696
38Sphingolipid metabolism_Homo sapiens_hsa006000.91754314
39mTOR signaling pathway_Homo sapiens_hsa041500.86916836
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86714069
41Synaptic vesicle cycle_Homo sapiens_hsa047210.86263494
42Glucagon signaling pathway_Homo sapiens_hsa049220.85496088
43Starch and sucrose metabolism_Homo sapiens_hsa005000.80084757
44Renin secretion_Homo sapiens_hsa049240.79624759
45beta-Alanine metabolism_Homo sapiens_hsa004100.79553754
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78858215
47Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78726062
48Pyruvate metabolism_Homo sapiens_hsa006200.75972390
49ABC transporters_Homo sapiens_hsa020100.75915242
50Fatty acid degradation_Homo sapiens_hsa000710.73779781
51One carbon pool by folate_Homo sapiens_hsa006700.73153392
52AMPK signaling pathway_Homo sapiens_hsa041520.70852915
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69829889
54Retinol metabolism_Homo sapiens_hsa008300.69578072
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69261214
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69026605
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68237226
58Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67034853
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.66212527
60Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64997573
61Complement and coagulation cascades_Homo sapiens_hsa046100.64828209
62Glutathione metabolism_Homo sapiens_hsa004800.64162607
63Influenza A_Homo sapiens_hsa051640.63245911
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61899898
65Vibrio cholerae infection_Homo sapiens_hsa051100.60484526
66Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59039666
67Arachidonic acid metabolism_Homo sapiens_hsa005900.58254966
68Primary bile acid biosynthesis_Homo sapiens_hsa001200.58241048
69Insulin secretion_Homo sapiens_hsa049110.57192237
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56034294
71Fructose and mannose metabolism_Homo sapiens_hsa000510.54050205
72Tryptophan metabolism_Homo sapiens_hsa003800.49945273
73Carbon metabolism_Homo sapiens_hsa012000.48527683
74Notch signaling pathway_Homo sapiens_hsa043300.48318978
75Regulation of autophagy_Homo sapiens_hsa041400.46912671
76Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.45919065
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44597528
78Phototransduction_Homo sapiens_hsa047440.43994014
79Metabolic pathways_Homo sapiens_hsa011000.43854464
80Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43660227
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43387637
82Ether lipid metabolism_Homo sapiens_hsa005650.42544759
83Caffeine metabolism_Homo sapiens_hsa002320.40485925
84Vitamin B6 metabolism_Homo sapiens_hsa007500.39921857
85Sulfur relay system_Homo sapiens_hsa041220.39134565
86Arginine biosynthesis_Homo sapiens_hsa002200.36730480
87Lysine degradation_Homo sapiens_hsa003100.36710744
88Lysosome_Homo sapiens_hsa041420.35730655
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35457179
90Parkinsons disease_Homo sapiens_hsa050120.34812807
91Dorso-ventral axis formation_Homo sapiens_hsa043200.34673363
92Salivary secretion_Homo sapiens_hsa049700.33299493
93Amphetamine addiction_Homo sapiens_hsa050310.32347555
94Legionellosis_Homo sapiens_hsa051340.31597989
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31289151
96Oxidative phosphorylation_Homo sapiens_hsa001900.31194855
97Fatty acid metabolism_Homo sapiens_hsa012120.31028942
98PPAR signaling pathway_Homo sapiens_hsa033200.29182940
99Alzheimers disease_Homo sapiens_hsa050100.28760610
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.28092264
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27483638
102Glycerophospholipid metabolism_Homo sapiens_hsa005640.26858934
103FoxO signaling pathway_Homo sapiens_hsa040680.26322485
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25768893
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25633534
106Peroxisome_Homo sapiens_hsa041460.24249553
107Serotonergic synapse_Homo sapiens_hsa047260.23779253
108Histidine metabolism_Homo sapiens_hsa003400.22909413
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22711064
110Chemical carcinogenesis_Homo sapiens_hsa052040.21450852
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.20829668
112Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20793717
113Butanoate metabolism_Homo sapiens_hsa006500.19707287
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.19141582
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17748146
116Collecting duct acid secretion_Homo sapiens_hsa049660.13099377
117Pentose phosphate pathway_Homo sapiens_hsa000300.12278061
118Galactose metabolism_Homo sapiens_hsa000520.11109732
119Gastric acid secretion_Homo sapiens_hsa049710.10644865
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08587405
121Thyroid hormone synthesis_Homo sapiens_hsa049180.07649792
122Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07567042
123Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.06746659
124Calcium signaling pathway_Homo sapiens_hsa040200.05184358
125Glycosaminoglycan degradation_Homo sapiens_hsa005310.04199815
126Nitrogen metabolism_Homo sapiens_hsa009100.03421301
127Endometrial cancer_Homo sapiens_hsa052130.03271843
128Bile secretion_Homo sapiens_hsa049760.00595959
129Insulin resistance_Homo sapiens_hsa049310.00402605
130VEGF signaling pathway_Homo sapiens_hsa043700.00180926
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0274642
132Ribosome_Homo sapiens_hsa03010-0.0106506
133Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0047671

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