TMED7-TICAM2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.99479229
2COPI coating of Golgi vesicle (GO:0048205)5.99479229
3cell adhesion mediated by integrin (GO:0033627)5.58616362
4hemidesmosome assembly (GO:0031581)5.16636550
5skin morphogenesis (GO:0043589)4.75164280
6protein localization to endosome (GO:0036010)4.62138030
7maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.93969492
8mesodermal cell differentiation (GO:0048333)3.72107556
9substrate-dependent cell migration (GO:0006929)3.71037602
10positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.69741306
11COPII vesicle coating (GO:0048208)3.62976103
12endodermal cell differentiation (GO:0035987)3.61841964
13protein retention in ER lumen (GO:0006621)3.58342267
14cell-substrate junction assembly (GO:0007044)3.55420534
15wound healing, spreading of epidermal cells (GO:0035313)3.54009238
16hypotonic response (GO:0006971)3.49393495
17iron ion import (GO:0097286)3.44640045
18retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31517945
19regulation of metalloenzyme activity (GO:0048552)3.29671179
20vesicle coating (GO:0006901)3.26885188
21mammary gland epithelial cell proliferation (GO:0033598)3.19423588
22membrane raft organization (GO:0031579)3.03262064
23nuclear pore complex assembly (GO:0051292)3.00316769
24cellular copper ion homeostasis (GO:0006878)2.98036610
25hyaluronan catabolic process (GO:0030214)2.97060680
26basement membrane organization (GO:0071711)2.96026807
27detection of molecule of bacterial origin (GO:0032490)2.94702620
28wound healing, spreading of cells (GO:0044319)2.89932298
29collagen fibril organization (GO:0030199)2.89261765
30response to peptidoglycan (GO:0032494)2.87667639
31negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.86744567
32regulation of early endosome to late endosome transport (GO:2000641)2.85742319
33stress fiber assembly (GO:0043149)2.84893786
34negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.79438922
35positive regulation of blood vessel endothelial cell migration (GO:0043536)2.78872422
36regulation of transforming growth factor beta2 production (GO:0032909)2.75828511
37embryonic process involved in female pregnancy (GO:0060136)2.74878307
38dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.68055938
39heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.68013012
40negative regulation of protein localization to plasma membrane (GO:1903077)2.67984057
41response to laminar fluid shear stress (GO:0034616)2.66576691
42activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61412187
43endoplasmic reticulum unfolded protein response (GO:0030968)2.58385279
44barbed-end actin filament capping (GO:0051016)2.57726267
45positive regulation of endothelial cell apoptotic process (GO:2000353)2.57480906
46decidualization (GO:0046697)2.57368141
47regulation of macrophage cytokine production (GO:0010935)2.56904821
48membrane protein ectodomain proteolysis (GO:0006509)2.55425003
49regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.54259804
50positive regulation of nuclease activity (GO:0032075)2.52841186
51activation of Rac GTPase activity (GO:0032863)2.50837286
52positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.50214353
53natural killer cell mediated immunity (GO:0002228)2.49847368
54natural killer cell mediated cytotoxicity (GO:0042267)2.49847368
55nuclear pore organization (GO:0006999)2.47511459
56protein hydroxylation (GO:0018126)2.47320581
57pore complex assembly (GO:0046931)2.46898844
58peptidyl-proline hydroxylation (GO:0019511)2.46414334
59regulation of vitamin D biosynthetic process (GO:0060556)2.45369782
60negative regulation of anoikis (GO:2000811)2.44750839
61collagen metabolic process (GO:0032963)2.44381031
62oligosaccharide catabolic process (GO:0009313)2.44306864
63cellular response to vitamin D (GO:0071305)2.43591436
64sphingosine metabolic process (GO:0006670)2.42738602
65chondrocyte proliferation (GO:0035988)2.42217557
66regulation of transforming growth factor beta1 production (GO:0032908)2.41537513
67ER-nucleus signaling pathway (GO:0006984)2.39989726
68regulation of epidermal growth factor-activated receptor activity (GO:0007176)2.39328381
69cellular response to unfolded protein (GO:0034620)2.38873967
70chondrocyte development (GO:0002063)2.37584623
71serine transport (GO:0032329)2.37195790
72lipopolysaccharide-mediated signaling pathway (GO:0031663)2.34851200
73regulation of nuclease activity (GO:0032069)2.34438331
74cellular response to arsenic-containing substance (GO:0071243)2.34027934
75apoptotic cell clearance (GO:0043277)2.32973214
76modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.32794051
77positive regulation by organism of defense response of other organism involved in symbiotic interact2.32794051
78modulation by symbiont of host immune response (GO:0052553)2.32794051
79positive regulation by symbiont of host defense response (GO:0052509)2.32794051
80modulation by symbiont of host defense response (GO:0052031)2.32794051
81modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.32794051
82extracellular matrix disassembly (GO:0022617)2.30371936
83positive regulation of interleukin-6 production (GO:0032755)2.28683454
84collagen catabolic process (GO:0030574)2.27911473
85positive regulation of leukocyte degranulation (GO:0043302)2.26923024
86regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.26599724
87focal adhesion assembly (GO:0048041)2.26422090
88cell-substrate adherens junction assembly (GO:0007045)2.26422090
89regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.26176658
90cellular response to vitamin (GO:0071295)2.24628392
91protein maturation by protein folding (GO:0022417)2.23582454
92chondroitin sulfate biosynthetic process (GO:0030206)2.23435119
93regulation of membrane protein ectodomain proteolysis (GO:0051043)2.23229058
94multicellular organismal macromolecule metabolic process (GO:0044259)2.23196730
95positive regulation of receptor recycling (GO:0001921)2.21946699
96response to vitamin D (GO:0033280)2.21704339
97cellular response to interferon-alpha (GO:0035457)2.21471278
98cellular protein complex localization (GO:0034629)2.21206935
99mitotic chromosome condensation (GO:0007076)2.20549431
100positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.19728051

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.29437662
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.06481751
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.93135562
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.52556218
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.03032599
6ZNF263_19887448_ChIP-Seq_K562_Human2.92511625
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.86039709
8CLOCK_20551151_ChIP-Seq_293T_Human2.71851757
9SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.56713394
10SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.56713394
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.41815368
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.39963426
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.38584140
14FOXM1_23109430_ChIP-Seq_U2OS_Human2.31943574
15WT1_19549856_ChIP-ChIP_CCG9911_Human2.23012415
16KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human2.21068618
17SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.16831230
18NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16661026
19NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.16564610
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.13128935
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.11053809
22AR_21909140_ChIP-Seq_LNCAP_Human2.06871200
23Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.01052508
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.00627190
25TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.99881348
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.97412517
27BRD4_25478319_ChIP-Seq_HGPS_Human1.96035816
28UBF1/2_26484160_Chip-Seq_HMECs_Human1.88151849
29TFEB_21752829_ChIP-Seq_HELA_Human1.88009719
30RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86008109
31ATF3_27146783_Chip-Seq_COLON_Human1.85418092
32KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.82858427
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78556578
34ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.77748239
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.76622315
36P300_27058665_Chip-Seq_ZR-75-30cells_Human1.72421562
37JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.67761210
38HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.66383932
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.63627762
40HIF1A_21447827_ChIP-Seq_MCF-7_Human1.63371445
41SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60799638
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.56484242
43FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56312839
44PPAR_26484153_Chip-Seq_NCI-H1993_Human1.55118984
45ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.54962443
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52044798
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.50124326
48E2F7_22180533_ChIP-Seq_HELA_Human1.48289732
49CJUN_26792858_Chip-Seq_BT549_Human1.47688099
50JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.46757477
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.44306697
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.39423384
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.37420456
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.34029750
55EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.32113368
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.31678172
57TP53_22127205_ChIP-Seq_IMR90_Human1.31668082
58NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.21000079
59MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20234780
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.18451322
61EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.18041796
62RACK7_27058665_Chip-Seq_MCF-7_Human1.16331457
63TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14075811
64SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13506058
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12235389
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11821331
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11327788
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.11170766
69STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11123494
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09255554
71TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08966068
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08848447
73WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06750629
74SOX2_20726797_ChIP-Seq_SW620_Human1.06517170
75MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.05902507
76TP53_16413492_ChIP-PET_HCT116_Human1.05295107
77NELFA_20434984_ChIP-Seq_ESCs_Mouse1.05149931
78SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03461939
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01920112
80ESR2_21235772_ChIP-Seq_MCF-7_Human1.01353083
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00090425
82FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.99989329
83ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98946107
84ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97869396
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96850185
86TP53_18474530_ChIP-ChIP_U2OS_Human0.96598144
87ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.95529263
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.94946158
89ESR1_20079471_ChIP-ChIP_T-47D_Human0.94711277
90PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93418448
91CHD1_26751641_Chip-Seq_LNCaP_Human0.93063946
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.92866564
93GATA1_22025678_ChIP-Seq_K562_Human0.92547860
94IRF8_22096565_ChIP-ChIP_GC-B_Human0.91997046
95NCOR1_26117541_ChIP-Seq_K562_Human0.91640804
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90315141
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90003196
98UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.88543167
99NFIB_24661679_ChIP-Seq_LUNG_Mouse0.85978086
100RUNX1_22412390_ChIP-Seq_EML_Mouse0.84167485

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.35835936
2MP0003705_abnormal_hypodermis_morpholog3.63408508
3MP0003566_abnormal_cell_adhesion3.19137237
4MP0004272_abnormal_basement_membrane3.12488383
5MP0005275_abnormal_skin_tensile2.58140616
6MP0002877_abnormal_melanocyte_morpholog2.57070302
7MP0003091_abnormal_cell_migration2.50366027
8MP0005451_abnormal_body_composition2.45576655
9MP0010352_gastrointestinal_tract_polyps2.36085271
10MP0005623_abnormal_meninges_morphology2.21555706
11MP0005257_abnormal_intraocular_pressure2.21424163
12MP0010234_abnormal_vibrissa_follicle2.12768178
13MP0003191_abnormal_cellular_cholesterol2.05590943
14MP0002060_abnormal_skin_morphology2.04098991
15MP0003950_abnormal_plasma_membrane1.97971534
16MP0005058_abnormal_lysosome_morphology1.93523477
17MP0005023_abnormal_wound_healing1.90494604
18MP0003300_gastrointestinal_ulcer1.87297218
19MP0003279_aneurysm1.86944383
20MP0009840_abnormal_foam_cell1.72111558
21MP0003941_abnormal_skin_development1.71182784
22MP0000858_altered_metastatic_potential1.66013245
23MP0005076_abnormal_cell_differentiation1.56626089
24MP0006054_spinal_hemorrhage1.56161518
25MP0005164_abnormal_response_to1.53626962
26MP0008004_abnormal_stomach_pH1.51001218
27MP0005503_abnormal_tendon_morphology1.47959107
28MP0003828_pulmonary_edema1.47006798
29MP0008260_abnormal_autophagy1.43881309
30MP0003453_abnormal_keratinocyte_physiol1.43868626
31MP0004233_abnormal_muscle_weight1.40302555
32MP0001958_emphysema1.34742699
33MP0002896_abnormal_bone_mineralization1.33790654
34MP0005409_darkened_coat_color1.28519435
35MP0002295_abnormal_pulmonary_circulatio1.27859464
36MP0000343_altered_response_to1.25801040
37MP0003448_altered_tumor_morphology1.24350274
38MP0000767_abnormal_smooth_muscle1.23749206
39MP0003436_decreased_susceptibility_to1.18314555
40MP0001542_abnormal_bone_strength1.18296413
41MP0003172_abnormal_lysosome_physiology1.17234529
42MP0001216_abnormal_epidermal_layer1.15825309
43MP0004947_skin_inflammation1.14336319
44MP0009053_abnormal_anal_canal1.11963336
45MP0010368_abnormal_lymphatic_system1.11660679
46MP0006082_CNS_inflammation1.10890869
47MP0001849_ear_inflammation1.10777071
48MP0005621_abnormal_cell_physiology1.10488946
49MP0002998_abnormal_bone_remodeling1.07176150
50MP0001915_intracranial_hemorrhage1.06195105
51MP0001243_abnormal_dermal_layer1.05490754
52MP0002796_impaired_skin_barrier1.04181276
53MP0005165_increased_susceptibility_to1.04137410
54MP0009780_abnormal_chondrocyte_physiolo1.03653690
55MP0000733_abnormal_muscle_development1.01818302
56MP0000013_abnormal_adipose_tissue1.00780599
57MP0003656_abnormal_erythrocyte_physiolo0.99628847
58MP0001533_abnormal_skeleton_physiology0.96382613
59MP0003075_altered_response_to0.95552051
60MP0004883_abnormal_blood_vessel0.92890284
61MP0005501_abnormal_skin_physiology0.91719772
62MP0004510_myositis0.90546747
63MP0002006_tumorigenesis0.90169522
64MP0005508_abnormal_skeleton_morphology0.90021667
65MP0000762_abnormal_tongue_morphology0.88278252
66MP0001348_abnormal_lacrimal_gland0.86243519
67MP0005390_skeleton_phenotype0.85726365
68MP0000627_abnormal_mammary_gland0.85542100
69MP0003221_abnormal_cardiomyocyte_apopto0.84555376
70MP0004808_abnormal_hematopoietic_stem0.83312325
71MP0002332_abnormal_exercise_endurance0.82651102
72MP0008007_abnormal_cellular_replicative0.82259616
73MP0002166_altered_tumor_susceptibility0.80042216
74MP0005384_cellular_phenotype0.79112339
75MP0003303_peritoneal_inflammation0.78138229
76MP0002419_abnormal_innate_immunity0.78067592
77MP0009785_altered_susceptibility_to0.77980303
78MP0004185_abnormal_adipocyte_glucose0.77222155
79MP0000537_abnormal_urethra_morphology0.76971919
80MP0001835_abnormal_antigen_presentation0.76686171
81MP0000579_abnormal_nail_morphology0.73521153
82MP0008057_abnormal_DNA_replication0.73488633
83MP0005197_abnormal_uvea_morphology0.71968653
84MP0000358_abnormal_cell_content/0.71057620
85MP0000371_diluted_coat_color0.69928733
86MP0000003_abnormal_adipose_tissue0.68908930
87MP0002148_abnormal_hypersensitivity_rea0.68848466
88MP0010771_integument_phenotype0.68717489
89MP0002086_abnormal_extraembryonic_tissu0.68114913
90MP0000350_abnormal_cell_proliferation0.67975439
91MP0004134_abnormal_chest_morphology0.67093698
92MP0003795_abnormal_bone_structure0.66928304
93MP0004264_abnormal_extraembryonic_tissu0.65757647
94MP0005464_abnormal_platelet_physiology0.65753074
95MP0010307_abnormal_tumor_latency0.65349672
96MP0001881_abnormal_mammary_gland0.64989993
97MP0002269_muscular_atrophy0.64800412
98MP0000749_muscle_degeneration0.63200736
99MP0002113_abnormal_skeleton_development0.62487513
100MP0003183_abnormal_peptide_metabolism0.62016666

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.52272795
2Protrusio acetabuli (HP:0003179)4.59264425
3Atrophic scars (HP:0001075)3.81270847
4Arterial tortuosity (HP:0005116)3.49731187
5Vascular tortuosity (HP:0004948)3.47764104
6Vertebral compression fractures (HP:0002953)3.40305536
7Abnormality of liposaccharide metabolism (HP:0010968)3.30546835
8Abnormality of glycosphingolipid metabolism (HP:0004343)3.30546835
9Abnormality of glycolipid metabolism (HP:0010969)3.30546835
10Ankle contracture (HP:0006466)3.08897657
11Fragile skin (HP:0001030)3.08362687
12Aortic dissection (HP:0002647)3.01207957
13Wormian bones (HP:0002645)2.91613246
14Spinal rigidity (HP:0003306)2.91173109
15Spondylolisthesis (HP:0003302)2.88068018
16Follicular hyperkeratosis (HP:0007502)2.81130040
17Osteolytic defects of the hand bones (HP:0009699)2.74074568
18Osteolytic defects of the phalanges of the hand (HP:0009771)2.74074568
19Thoracolumbar scoliosis (HP:0002944)2.62633203
20Dilatation of the ascending aorta (HP:0005111)2.60846101
21Bladder diverticulum (HP:0000015)2.59098804
22Mitral stenosis (HP:0001718)2.58095902
23Cervical subluxation (HP:0003308)2.54977977
24Aortic aneurysm (HP:0004942)2.52103187
25Short nail (HP:0001799)2.51336189
26Genu recurvatum (HP:0002816)2.49449016
27Ankyloglossia (HP:0010296)2.48636615
28Milia (HP:0001056)2.44513000
29Elbow flexion contracture (HP:0002987)2.43339254
30Spinal cord lesions (HP:0100561)2.37015959
31Syringomyelia (HP:0003396)2.37015959
32Blue sclerae (HP:0000592)2.34508426
33Onycholysis (HP:0001806)2.31308086
34Soft skin (HP:0000977)2.31113937
35Abnormality of oral frenula (HP:0000190)2.30325254
36Thick nail (HP:0001805)2.29268731
37Achilles tendon contracture (HP:0001771)2.25740896
38Peritonitis (HP:0002586)2.24366483
39Tetraparesis (HP:0002273)2.21238795
40Increased connective tissue (HP:0009025)2.19507667
41Abnormality of the distal phalanges of the toes (HP:0010182)2.15585481
42J-shaped sella turcica (HP:0002680)2.15334634
43Ridged nail (HP:0001807)2.14870556
44Abnormality of the acetabulum (HP:0003170)2.11799513
45Orthostatic hypotension (HP:0001278)2.09976896
46Abnormality of the Achilles tendon (HP:0005109)2.04538867
47Abnormality of dentin (HP:0010299)2.04173502
48Urinary glycosaminoglycan excretion (HP:0003541)2.02178289
49Mucopolysacchariduria (HP:0008155)2.02178289
50Ulnar bowing (HP:0003031)2.01933113
51Myocardial infarction (HP:0001658)2.00540656
52Slender build (HP:0001533)2.00501070
53Upper limb amyotrophy (HP:0009129)1.98326444
54Distal upper limb amyotrophy (HP:0007149)1.98326444
55Cardiovascular calcification (HP:0011915)1.98052259
56Flat acetabular roof (HP:0003180)1.95798412
57Insomnia (HP:0100785)1.95336677
58Absent frontal sinuses (HP:0002688)1.93867454
59Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.92875446
60Natal tooth (HP:0000695)1.91276153
61Cerebral inclusion bodies (HP:0100314)1.90878597
62Joint laxity (HP:0001388)1.89968077
63Cerebral aneurysm (HP:0004944)1.88703749
64Dysostosis multiplex (HP:0000943)1.88204444
65Generalized amyotrophy (HP:0003700)1.87133364
66Abnormality of polysaccharide metabolism (HP:0011012)1.85541737
67Abnormality of glycosaminoglycan metabolism (HP:0004371)1.85541737
68Abnormality of mucopolysaccharide metabolism (HP:0011020)1.85541737
69Mitral valve prolapse (HP:0001634)1.85037618
70Vertebral arch anomaly (HP:0008438)1.84227135
71Aneurysm (HP:0002617)1.83790199
72Distal lower limb amyotrophy (HP:0008944)1.83754766
73Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.83094711
74Thin bony cortex (HP:0002753)1.82327648
75Aortic regurgitation (HP:0001659)1.81976104
76Entropion (HP:0000621)1.78877102
77Neurofibrillary tangles (HP:0002185)1.77633566
78Relative macrocephaly (HP:0004482)1.77606411
79Overgrowth (HP:0001548)1.77241534
80Increased variability in muscle fiber diameter (HP:0003557)1.76497984
81Hyperextensible skin (HP:0000974)1.73828837
82Hand muscle atrophy (HP:0009130)1.73723020
83Deformed sella turcica (HP:0002681)1.70971410
84Mildly elevated creatine phosphokinase (HP:0008180)1.69619500
85Disproportionate tall stature (HP:0001519)1.68181222
86Upper limb muscle weakness (HP:0003484)1.67513235
87Broad face (HP:0000283)1.66653747
88Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.66427899
89Abnormality of skeletal muscle fiber size (HP:0012084)1.66405324
90Delayed closure of the anterior fontanelle (HP:0001476)1.66168016
91Selective tooth agenesis (HP:0001592)1.66002394
92Tibial bowing (HP:0002982)1.64925423
93Subacute progressive viral hepatitis (HP:0006572)1.64614193
94Ovoid vertebral bodies (HP:0003300)1.63722307
95Nail dystrophy (HP:0008404)1.63395027
96Abnormality of carpal bone ossification (HP:0006257)1.62835337
97Abnormal ossification of hand bones (HP:0005921)1.62788551
98Periodontitis (HP:0000704)1.62693411
99Hyperacusis (HP:0010780)1.62511247
100Fragile nails (HP:0001808)1.62280944

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK33.33441334
2LATS23.10763863
3MST1R2.79392251
4EPHA22.66146525
5CDK122.42967883
6SCYL22.38008882
7PDGFRA2.31154984
8ARAF2.18948061
9PRPF4B2.03136654
10MOS2.02319066
11TRIB31.99876468
12ERN11.99491918
13MAP3K31.84383124
14PTK21.82629465
15MET1.82213998
16PAK41.80758867
17LATS11.79311796
18NME21.75816438
19TRPM71.68678317
20NEK91.66153024
21TGFBR21.60370601
22KSR21.58488482
23TTN1.56422167
24EIF2AK11.53906528
25MAP2K31.50927431
26EPHB21.40843312
27MAP3K21.40244055
28SIK11.39806544
29STK101.38395715
30EPHB11.37570053
31PIM21.35403200
32ERBB41.33223829
33TAOK21.33128915
34EIF2AK31.26711965
35KSR11.26518813
36MAP3K121.26382723
37DDR21.24949168
38MAP3K141.23131462
39BMPR21.19353021
40ICK1.17054940
41RIPK11.16713878
42MYLK1.16507841
43NEK11.12215291
44RAF11.08991642
45STK381.08841395
46TESK11.05692799
47MAP3K81.00581004
48STK30.99476285
49TESK20.98920941
50MAP3K10.96711649
51MAP3K130.95886688
52ERBB30.95135285
53BRAF0.94929669
54PAK20.92633537
55MAP3K60.90886802
56ABL20.89795444
57NTRK10.89727834
58GRK70.89108738
59MAP3K90.88450271
60IRAK40.87319779
61PDGFRB0.86632711
62TBK10.84073775
63MTOR0.80035934
64AKT30.79140188
65DYRK30.78102089
66JAK10.76659410
67FLT30.67539815
68STK40.67175995
69SMG10.64915757
70LRRK20.64642073
71MAP3K50.63746067
72JAK30.62918378
73TAOK10.62624555
74PKN20.62102587
75YES10.61697685
76CLK10.58728556
77CDK60.57682200
78TYK20.56058004
79ZAP700.54964150
80RPS6KA40.54720442
81CDK80.53359096
82STK38L0.52962901
83BRD40.52417379
84FGFR40.50422770
85CAMK1G0.49812738
86BMX0.49695505
87CDC42BPA0.49408253
88PDPK10.48707907
89PRKG20.48352573
90ROCK20.45937053
91IRAK20.45623794
92EEF2K0.43893419
93MELK0.43884477
94CSK0.42921014
95ILK0.40265844
96FGR0.39734584
97STK240.39424861
98PAK10.37914856
99CAMK1D0.37876685
100MARK30.36577173

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.14936846
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.89417097
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.03603766
4Bladder cancer_Homo sapiens_hsa052191.97752422
5Other glycan degradation_Homo sapiens_hsa005111.94850599
6ECM-receptor interaction_Homo sapiens_hsa045121.90947255
7Focal adhesion_Homo sapiens_hsa045101.79657939
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.70340106
9Chronic myeloid leukemia_Homo sapiens_hsa052201.70148133
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69505452
11Small cell lung cancer_Homo sapiens_hsa052221.67987795
12Shigellosis_Homo sapiens_hsa051311.63693515
13Proteoglycans in cancer_Homo sapiens_hsa052051.61482250
14Thyroid cancer_Homo sapiens_hsa052161.56801689
15Glycosaminoglycan degradation_Homo sapiens_hsa005311.56175682
16AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.54159122
17Adherens junction_Homo sapiens_hsa045201.50240341
18Amoebiasis_Homo sapiens_hsa051461.49263341
19Malaria_Homo sapiens_hsa051441.48852732
20Renal cell carcinoma_Homo sapiens_hsa052111.44190710
21Lysosome_Homo sapiens_hsa041421.42509977
22Pancreatic cancer_Homo sapiens_hsa052121.35993266
23Central carbon metabolism in cancer_Homo sapiens_hsa052301.33843683
24Hepatitis B_Homo sapiens_hsa051611.33638428
25Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.31421589
26TNF signaling pathway_Homo sapiens_hsa046681.31032474
27Vibrio cholerae infection_Homo sapiens_hsa051101.30011702
28Toxoplasmosis_Homo sapiens_hsa051451.28054086
29Legionellosis_Homo sapiens_hsa051341.27147666
30Influenza A_Homo sapiens_hsa051641.25333559
31Prion diseases_Homo sapiens_hsa050201.19799048
32MicroRNAs in cancer_Homo sapiens_hsa052061.17573034
33Apoptosis_Homo sapiens_hsa042101.16745147
34Leishmaniasis_Homo sapiens_hsa051401.16104289
35Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15987239
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15093885
37Osteoclast differentiation_Homo sapiens_hsa043801.12812658
38Salmonella infection_Homo sapiens_hsa051321.12662175
39Measles_Homo sapiens_hsa051621.12472251
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.10889853
41p53 signaling pathway_Homo sapiens_hsa041151.10175733
42Acute myeloid leukemia_Homo sapiens_hsa052211.09966819
43Phagosome_Homo sapiens_hsa041451.09319929
44Viral carcinogenesis_Homo sapiens_hsa052031.08239560
45Regulation of actin cytoskeleton_Homo sapiens_hsa048101.07444195
46Sulfur metabolism_Homo sapiens_hsa009201.04336748
47Prostate cancer_Homo sapiens_hsa052151.04145398
48Endometrial cancer_Homo sapiens_hsa052131.02600670
49Tuberculosis_Homo sapiens_hsa051521.01262478
50Non-small cell lung cancer_Homo sapiens_hsa052230.99510323
51Hepatitis C_Homo sapiens_hsa051600.99337316
52N-Glycan biosynthesis_Homo sapiens_hsa005100.97006211
53Pertussis_Homo sapiens_hsa051330.96171926
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93521057
55ErbB signaling pathway_Homo sapiens_hsa040120.93012266
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.92544267
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92008038
58Prolactin signaling pathway_Homo sapiens_hsa049170.88612066
59Galactose metabolism_Homo sapiens_hsa000520.87781223
60PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85323837
61Sphingolipid metabolism_Homo sapiens_hsa006000.84834020
62VEGF signaling pathway_Homo sapiens_hsa043700.83756512
63NOD-like receptor signaling pathway_Homo sapiens_hsa046210.83534408
64TGF-beta signaling pathway_Homo sapiens_hsa043500.82804668
65Melanoma_Homo sapiens_hsa052180.82543269
66B cell receptor signaling pathway_Homo sapiens_hsa046620.81472380
67Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79129171
68Leukocyte transendothelial migration_Homo sapiens_hsa046700.78598696
69Endocytosis_Homo sapiens_hsa041440.76476244
70Pentose phosphate pathway_Homo sapiens_hsa000300.75184463
71Glioma_Homo sapiens_hsa052140.75134238
72Pathways in cancer_Homo sapiens_hsa052000.74747035
73HIF-1 signaling pathway_Homo sapiens_hsa040660.73713359
74Herpes simplex infection_Homo sapiens_hsa051680.73460715
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.71929971
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71530133
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.71424060
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.70617069
79Rheumatoid arthritis_Homo sapiens_hsa053230.68650365
80FoxO signaling pathway_Homo sapiens_hsa040680.66845020
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66012361
82Viral myocarditis_Homo sapiens_hsa054160.64212495
83Protein digestion and absorption_Homo sapiens_hsa049740.63691997
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63209851
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.63206582
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62377490
87Hematopoietic cell lineage_Homo sapiens_hsa046400.62027987
88HTLV-I infection_Homo sapiens_hsa051660.61739086
89mTOR signaling pathway_Homo sapiens_hsa041500.58851330
90Systemic lupus erythematosus_Homo sapiens_hsa053220.57591106
91Estrogen signaling pathway_Homo sapiens_hsa049150.57452439
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55631933
93Insulin signaling pathway_Homo sapiens_hsa049100.53392609
94Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53029875
95African trypanosomiasis_Homo sapiens_hsa051430.51155207
96Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49595190
97Chemokine signaling pathway_Homo sapiens_hsa040620.48195313
98Cell cycle_Homo sapiens_hsa041100.47708992
99Colorectal cancer_Homo sapiens_hsa052100.47356559
100Hippo signaling pathway_Homo sapiens_hsa043900.47268783

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