TMED8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)5.84411900
2COPI coating of Golgi vesicle (GO:0048205)5.84411900
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.96753326
4mitotic sister chromatid cohesion (GO:0007064)4.73615349
5synaptic vesicle maturation (GO:0016188)4.70615532
6protein K11-linked deubiquitination (GO:0035871)4.66030014
7regulation of short-term neuronal synaptic plasticity (GO:0048172)4.57847215
8B cell receptor signaling pathway (GO:0050853)4.51542738
9regulation of histone H3-K9 methylation (GO:0051570)4.28265208
10locomotory exploration behavior (GO:0035641)4.26177210
11interkinetic nuclear migration (GO:0022027)4.24366653
12phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.18183131
13positive regulation of histone H3-K4 methylation (GO:0051571)4.18162431
14regulation of synaptic vesicle exocytosis (GO:2000300)4.11753953
15histone H3-K9 methylation (GO:0051567)4.08264828
16insulin secretion (GO:0030073)4.07835580
17retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.02746437
18histone H3-K9 modification (GO:0061647)3.92615294
19negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.88897064
20nuclear pore complex assembly (GO:0051292)3.85171280
21protein maturation by protein folding (GO:0022417)3.84726948
22nuclear pore organization (GO:0006999)3.81889090
23positive regulation of DNA-templated transcription, initiation (GO:2000144)3.78104987
24positive regulation of granulocyte differentiation (GO:0030854)3.76968432
25regulation of histone H3-K4 methylation (GO:0051569)3.74737220
26regulation of B cell receptor signaling pathway (GO:0050855)3.74411124
27activation of protein kinase A activity (GO:0034199)3.70109195
28cytoplasmic mRNA processing body assembly (GO:0033962)3.65743210
29protein targeting to Golgi (GO:0000042)3.60370634
30protein K48-linked deubiquitination (GO:0071108)3.57842148
31synaptic vesicle exocytosis (GO:0016079)3.57398664
32peptide hormone processing (GO:0016486)3.56940286
33peptidyl-threonine dephosphorylation (GO:0035970)3.56598737
34regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.53955341
35detection of calcium ion (GO:0005513)3.53446648
36monoubiquitinated protein deubiquitination (GO:0035520)3.49498493
37negative regulation of histone methylation (GO:0031061)3.45028018
38sister chromatid cohesion (GO:0007062)3.43307462
39regulation of synaptic vesicle transport (GO:1902803)3.40216406
40vesicle transport along microtubule (GO:0047496)3.40090624
41vesicle coating (GO:0006901)3.38853826
42endocrine pancreas development (GO:0031018)3.38397676
43histone H3-K4 trimethylation (GO:0080182)3.37929273
44positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.35519948
45establishment of protein localization to Golgi (GO:0072600)3.34599925
46chemosensory behavior (GO:0007635)3.32889880
47regulation of ARF protein signal transduction (GO:0032012)3.29026880
48regulation of response to tumor cell (GO:0002834)3.28806681
49positive regulation of response to tumor cell (GO:0002836)3.28806681
50positive regulation of immune response to tumor cell (GO:0002839)3.28806681
51regulation of immune response to tumor cell (GO:0002837)3.28806681
52Golgi to endosome transport (GO:0006895)3.28639096
53activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.27782696
54regulation of beta-amyloid formation (GO:1902003)3.27210798
55retrograde transport, vesicle recycling within Golgi (GO:0000301)3.26506361
56peptidyl-lysine trimethylation (GO:0018023)3.26047489
57glutamate secretion (GO:0014047)3.25985461
58negative regulation of neurotransmitter secretion (GO:0046929)3.25299847
59megakaryocyte development (GO:0035855)3.19989495
60maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19987041
61snRNA transcription (GO:0009301)3.19099866
62phosphatidylinositol dephosphorylation (GO:0046856)3.18569339
63intra-Golgi vesicle-mediated transport (GO:0006891)3.17621309
64positive regulation of insulin secretion (GO:0032024)3.14668867
65regulation of insulin secretion (GO:0050796)3.13792730
66positive regulation of mitotic sister chromatid separation (GO:1901970)3.13531992
67positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13531992
68positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13531992
69regulation of Rac protein signal transduction (GO:0035020)3.13243900
70regulation of amyloid precursor protein catabolic process (GO:1902991)3.11837633
71proline transport (GO:0015824)3.10289862
72phospholipid dephosphorylation (GO:0046839)3.09013700
73positive regulation of nuclease activity (GO:0032075)3.08444648
74neurotransmitter secretion (GO:0007269)3.07187049
75positive regulation of gamma-delta T cell activation (GO:0046645)3.07005837
76positive regulation of developmental pigmentation (GO:0048087)3.06971710
77histone lysine methylation (GO:0034968)3.03450832
78regulation of DNA endoreduplication (GO:0032875)3.03447611
79type B pancreatic cell development (GO:0003323)3.03334228
80peptide hormone secretion (GO:0030072)3.03272718
81regulation of calcium ion-dependent exocytosis (GO:0017158)3.03041117
82negative regulation of cytosolic calcium ion concentration (GO:0051481)3.02944275
83cellular response to ethanol (GO:0071361)3.01595089
84COPII vesicle coating (GO:0048208)3.01425361
85suckling behavior (GO:0001967)3.00778650
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.00330969
87layer formation in cerebral cortex (GO:0021819)2.98205292
88cellular response to glucagon stimulus (GO:0071377)2.97317029
89peptide secretion (GO:0002790)2.96447385
90L-alpha-amino acid transmembrane transport (GO:1902475)2.95432192
91regulation of histone methylation (GO:0031060)2.94474004
92positive regulation of histone methylation (GO:0031062)2.94432984
93nerve growth factor signaling pathway (GO:0038180)2.91607458
94macroautophagy (GO:0016236)2.91241228
95negative regulation of neurotransmitter transport (GO:0051589)2.88834633
96positive regulation of synaptic transmission, GABAergic (GO:0032230)2.88103931
97positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.88034112
98regulation of peptide hormone secretion (GO:0090276)2.84819506
99positive regulation of exocytosis (GO:0045921)2.84484174
100exploration behavior (GO:0035640)2.84282432
101regulation of peptide secretion (GO:0002791)2.83735743
102glucocorticoid receptor signaling pathway (GO:0042921)2.83033344
103cerebellar Purkinje cell layer development (GO:0021680)2.81791965
104membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.81385428
105organelle transport along microtubule (GO:0072384)2.80656547
106positive regulation of Rap GTPase activity (GO:0032854)2.80244132
107peptidyl-lysine methylation (GO:0018022)2.80030271
108protein localization to Golgi apparatus (GO:0034067)2.79472601
109histone H3-K36 demethylation (GO:0070544)2.79302027
110regulation of type B pancreatic cell apoptotic process (GO:2000674)2.78890223
111neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.78705362
112lipid translocation (GO:0034204)2.78507769
113phospholipid translocation (GO:0045332)2.78507769
114ER overload response (GO:0006983)2.78290463
115regulation of nuclease activity (GO:0032069)2.77496919
116cerebellar Purkinje cell differentiation (GO:0021702)2.75539420
117regulation of histone H3-K27 methylation (GO:0061085)2.74691442
118neuronal action potential propagation (GO:0019227)2.74455552
119positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74145842
120dosage compensation (GO:0007549)2.72502856
121endoplasmic reticulum unfolded protein response (GO:0030968)2.71398911
122regulation of glucocorticoid secretion (GO:2000849)2.71209836
123response to ischemia (GO:0002931)2.70094888
124regulation of establishment of cell polarity (GO:2000114)2.68330261
125stress granule assembly (GO:0034063)2.68097100
126regulation of exocytosis (GO:0017157)2.67888805
127protein retention in ER lumen (GO:0006621)2.66447537
128glandular epithelial cell development (GO:0002068)2.65841685
129histone methylation (GO:0016571)2.65182290
130signal release (GO:0023061)2.65136207
131regulation of glutamate receptor signaling pathway (GO:1900449)2.64326707
132lymphoid progenitor cell differentiation (GO:0002320)2.64128632
133regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.64053463
134definitive hemopoiesis (GO:0060216)2.64023919
135cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.64020004
136cellular response to unfolded protein (GO:0034620)2.63262029
137non-recombinational repair (GO:0000726)2.62963789
138double-strand break repair via nonhomologous end joining (GO:0006303)2.62963789
139corticosteroid receptor signaling pathway (GO:0031958)2.62472805
140pore complex assembly (GO:0046931)2.62312609
141regulation of pigment cell differentiation (GO:0050932)2.62008131
142regulation of neuronal synaptic plasticity (GO:0048168)2.61986873
143positive regulation of peptide hormone secretion (GO:0090277)2.60868734
144hepatocyte apoptotic process (GO:0097284)2.60235334
145nucleus localization (GO:0051647)2.59747100
146positive regulation of peptide secretion (GO:0002793)2.59475151
147negative regulation of calcium ion transport into cytosol (GO:0010523)2.59365773
148ER-nucleus signaling pathway (GO:0006984)2.56338814
149righting reflex (GO:0060013)2.54743387
150regulation of clathrin-mediated endocytosis (GO:2000369)2.54271841
151histone H3-K4 methylation (GO:0051568)2.52421209
152cellular response to topologically incorrect protein (GO:0035967)2.51957813
153innervation (GO:0060384)2.51258491
154dendritic spine morphogenesis (GO:0060997)2.50114197
155positive regulation by host of viral transcription (GO:0043923)2.49512633
156cellular potassium ion homeostasis (GO:0030007)2.49304271
157regulation of hormone secretion (GO:0046883)2.49068193
158regulation of RNA export from nucleus (GO:0046831)2.48435886
159sodium ion export (GO:0071436)2.48123384
160inner ear receptor cell development (GO:0060119)2.47588891
161necroptotic process (GO:0070266)2.46998846
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.46607724
163potassium ion import (GO:0010107)2.46374098
164regulation of Rap GTPase activity (GO:0032317)2.46255607
165positive regulation of B cell differentiation (GO:0045579)2.45901339
166membrane repolarization during action potential (GO:0086011)2.45847330
167regulation of centriole replication (GO:0046599)2.45497614
168regulation of long-term neuronal synaptic plasticity (GO:0048169)2.45379782
169regulation of vesicle fusion (GO:0031338)2.45375468
170mitochondrial DNA replication (GO:0006264)2.45190434
171relaxation of cardiac muscle (GO:0055119)2.44983281
172DNA-dependent DNA replication (GO:0006261)2.43897518
173toxin metabolic process (GO:0009404)2.42888188
174polyol catabolic process (GO:0046174)2.42225155
175early endosome to late endosome transport (GO:0045022)2.41416300
176neural tube formation (GO:0001841)2.40832760
177glandular epithelial cell differentiation (GO:0002067)2.40600599
178dendrite morphogenesis (GO:0048813)2.40182842
179positive regulation of dendritic spine morphogenesis (GO:0061003)2.39356944
180folic acid-containing compound biosynthetic process (GO:0009396)2.39193476
181histone mRNA catabolic process (GO:0071044)2.39006241
182protein K63-linked deubiquitination (GO:0070536)2.38234247
183microtubule anchoring (GO:0034453)2.37171118
184regulation of gamma-delta T cell activation (GO:0046643)2.36658847
185G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.36303136
186regulation of DNA-templated transcription, initiation (GO:2000142)2.36138177
187meiotic chromosome segregation (GO:0045132)2.35732278
188regulation of gamma-delta T cell differentiation (GO:0045586)2.35427717
189protein alkylation (GO:0008213)2.34829834
190protein methylation (GO:0006479)2.34829834
191peptidyl-threonine phosphorylation (GO:0018107)2.33664968
192DNA unwinding involved in DNA replication (GO:0006268)2.33170636
193DNA duplex unwinding (GO:0032508)2.30529139
194attachment of spindle microtubules to kinetochore (GO:0008608)2.30315020
195DNA geometric change (GO:0032392)2.28969459

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.09946052
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.42341432
3EZH2_22144423_ChIP-Seq_EOC_Human4.28124668
4SALL1_21062744_ChIP-ChIP_HESCs_Human2.72267815
5GATA1_22025678_ChIP-Seq_K562_Human2.69754055
6RARB_27405468_Chip-Seq_BRAIN_Mouse2.67306695
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.65214742
8REST_21632747_ChIP-Seq_MESCs_Mouse2.58292678
9DROSHA_22980978_ChIP-Seq_HELA_Human2.17695547
10REST_18959480_ChIP-ChIP_MESCs_Mouse2.14303981
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10833038
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.97152190
13CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.96626018
14* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.95050541
15GBX2_23144817_ChIP-Seq_PC3_Human1.94954063
16E2F4_17652178_ChIP-ChIP_JURKAT_Human1.93299629
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.91557997
18EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.89460878
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84695472
20ER_23166858_ChIP-Seq_MCF-7_Human1.84027130
21TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.84024504
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.82171635
23SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.81689321
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80976977
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.79650522
26NR3C1_23031785_ChIP-Seq_PC12_Mouse1.76168315
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65737841
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.62718569
29FUS_26573619_Chip-Seq_HEK293_Human1.62271583
30SMAD4_21799915_ChIP-Seq_A2780_Human1.60498897
31EWS_26573619_Chip-Seq_HEK293_Human1.58862950
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.58603255
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.57893057
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.57694633
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.56568744
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56489230
37ZNF274_21170338_ChIP-Seq_K562_Hela1.55045693
38STAT3_23295773_ChIP-Seq_U87_Human1.55027291
39DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.52668499
40SOX2_21211035_ChIP-Seq_LN229_Gbm1.50907683
41SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48733270
42JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47509595
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46865847
44TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44720453
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44314291
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.40949805
47KDM2B_26808549_Chip-Seq_K562_Human1.39652668
48SCL_19346495_ChIP-Seq_HPC-7_Human1.39355799
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.39237836
50SUZ12_27294783_Chip-Seq_ESCs_Mouse1.38446684
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.38161945
52AR_19668381_ChIP-Seq_PC3_Human1.37048954
53RNF2_18974828_ChIP-Seq_MESCs_Mouse1.37005453
54EZH2_18974828_ChIP-Seq_MESCs_Mouse1.37005453
55IRF8_22096565_ChIP-ChIP_GC-B_Human1.35780227
56SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35159504
57RNF2_27304074_Chip-Seq_ESCs_Mouse1.34822000
58MYC_22102868_ChIP-Seq_BL_Human1.34794700
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.33972125
60NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.33776647
61AHR_22903824_ChIP-Seq_MCF-7_Human1.30543590
62EZH2_27294783_Chip-Seq_ESCs_Mouse1.29574475
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27968783
64VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27708151
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27171776
66IGF1R_20145208_ChIP-Seq_DFB_Human1.23839493
67SMAD3_21741376_ChIP-Seq_ESCs_Human1.23103284
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23032026
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22708880
70E2F1_18555785_Chip-Seq_ESCs_Mouse1.21655781
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.21491420
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.20973511
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.20869850
74CMYC_18555785_Chip-Seq_ESCs_Mouse1.20590596
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20130369
76EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20074466
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19978976
78AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19942975
79RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18004760
80RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17737084
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.17450242
82SUZ12_18555785_Chip-Seq_ESCs_Mouse1.16881461
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16579792
84P53_22387025_ChIP-Seq_ESCs_Mouse1.15639778
85TCF4_23295773_ChIP-Seq_U87_Human1.15451142
86EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.14741794
87PADI4_21655091_ChIP-ChIP_MCF-7_Human1.14250225
88CTBP2_25329375_ChIP-Seq_LNCAP_Human1.13643779
89GATA1_19941826_ChIP-Seq_K562_Human1.13263838
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12508519
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12193450
92MYB_26560356_Chip-Seq_TH2_Human1.11664380
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.11526902
94CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11305607
95P300_18555785_Chip-Seq_ESCs_Mouse1.11281517
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10871419
97RUNX_20019798_ChIP-Seq_JUKART_Human1.10806195
98DNAJC2_21179169_ChIP-ChIP_NT2_Human1.10644525
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10500792
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10376299
101ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09806523
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.09455190
103FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08651104
104EZH2_27304074_Chip-Seq_ESCs_Mouse1.08399786
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.06859797
106CTBP1_25329375_ChIP-Seq_LNCAP_Human1.06817758
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06528374
108POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.06528374
109CBP_20019798_ChIP-Seq_JUKART_Human1.06511014
110IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.06511014
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06494714
112VDR_22108803_ChIP-Seq_LS180_Human1.05970762
113ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.05153140
114SMAD_19615063_ChIP-ChIP_OVARY_Human1.05053365
115FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04986508
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.04264412
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04062274
118TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02894028
119EGR1_19374776_ChIP-ChIP_THP-1_Human1.02556150
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02373867
121TOP2B_26459242_ChIP-Seq_MCF-7_Human1.02134270
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00869972
123POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00763180
124KDM2B_26808549_Chip-Seq_DND41_Human1.00589130
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.00522026
126ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00454581
127DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99464523
128UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99431912
129TAF15_26573619_Chip-Seq_HEK293_Human0.99399198
130RXR_22108803_ChIP-Seq_LS180_Human0.98752316
131EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98699738
132CIITA_25753668_ChIP-Seq_RAJI_Human0.98247704
133BCAT_22108803_ChIP-Seq_LS180_Human0.98051685
134OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98022777
135SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97765553
136NFE2_27457419_Chip-Seq_LIVER_Mouse0.97213931
137EZH2_27294783_Chip-Seq_NPCs_Mouse0.97204948
138IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97163621
139SOX2_18555785_Chip-Seq_ESCs_Mouse0.96572777
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.96287822
141CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95990580
142GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95800152
143STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.95615991
144ZFP281_18757296_ChIP-ChIP_E14_Mouse0.95488827
145SMRT_27268052_Chip-Seq_Bcells_Human0.94630333
146STAT3_18555785_Chip-Seq_ESCs_Mouse0.94623354
147RUNX2_22187159_ChIP-Seq_PCA_Human0.94411405
148PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94342095
149TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.93593029
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.92895935
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92665765
152GATA3_27048872_Chip-Seq_THYMUS_Human0.92577103
153P300_19829295_ChIP-Seq_ESCs_Human0.92137624
154FLI1_21867929_ChIP-Seq_TH2_Mouse0.91400741
155AR_25329375_ChIP-Seq_VCAP_Human0.90694757
156MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90300057
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.90133329
158TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.89946625
159SPI1_23127762_ChIP-Seq_K562_Human0.89662991
160KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89167281
161ZNF263_19887448_ChIP-Seq_K562_Human0.89003407

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.02874197
2MP0002909_abnormal_adrenal_gland4.13725671
3MP0002877_abnormal_melanocyte_morpholog3.87291482
4MP0004859_abnormal_synaptic_plasticity3.83803438
5MP0009780_abnormal_chondrocyte_physiolo3.61768692
6MP0000013_abnormal_adipose_tissue3.30007943
7MP0003283_abnormal_digestive_organ3.24843110
8MP0008877_abnormal_DNA_methylation3.22068806
9MP0004270_analgesia2.92807943
10MP0003183_abnormal_peptide_metabolism2.74711668
11MP0002396_abnormal_hematopoietic_system2.74145425
12MP0002693_abnormal_pancreas_physiology2.71384381
13MP0003635_abnormal_synaptic_transmissio2.64264294
14MP0005645_abnormal_hypothalamus_physiol2.56644880
15MP0008961_abnormal_basal_metabolism2.51598630
16MP0001944_abnormal_pancreas_morphology2.47876973
17MP0002009_preneoplasia2.36246911
18MP0010094_abnormal_chromosome_stability2.27337896
19MP0004043_abnormal_pH_regulation2.26133285
20MP0000015_abnormal_ear_pigmentation2.19067631
21MP0003300_gastrointestinal_ulcer2.18352911
22MP0005174_abnormal_tail_pigmentation2.09513551
23MP0000569_abnormal_digit_pigmentation2.09058864
24MP0002063_abnormal_learning/memory/cond2.02754663
25MP0010386_abnormal_urinary_bladder2.02206459
26MP0005075_abnormal_melanosome_morpholog1.97492945
27MP0005379_endocrine/exocrine_gland_phen1.94308125
28MP0003787_abnormal_imprinting1.88729158
29MP0002064_seizures1.85437934
30MP0009046_muscle_twitch1.85422407
31MP0009745_abnormal_behavioral_response1.83120841
32MP0004808_abnormal_hematopoietic_stem1.82656540
33MP0002572_abnormal_emotion/affect_behav1.80536284
34MP0005646_abnormal_pituitary_gland1.78924992
35MP0002734_abnormal_mechanical_nocicepti1.78802190
36MP0002733_abnormal_thermal_nociception1.76418633
37MP0000003_abnormal_adipose_tissue1.74022182
38MP0003122_maternal_imprinting1.71538272
39MP0000372_irregular_coat_pigmentation1.71219622
40MP0003172_abnormal_lysosome_physiology1.67114000
41MP0001501_abnormal_sleep_pattern1.63371788
42MP0002272_abnormal_nervous_system1.62196180
43MP0003763_abnormal_thymus_physiology1.61620767
44MP0008569_lethality_at_weaning1.60849325
45MP0002837_dystrophic_cardiac_calcinosis1.59962602
46MP0004858_abnormal_nervous_system1.58375251
47MP0002078_abnormal_glucose_homeostasis1.55607069
48MP0000678_abnormal_parathyroid_gland1.55143269
49MP0003880_abnormal_central_pattern1.53646695
50MP0006072_abnormal_retinal_apoptosis1.49478945
51MP0001970_abnormal_pain_threshold1.45063871
52MP0003890_abnormal_embryonic-extraembry1.43583217
53MP0001968_abnormal_touch/_nociception1.42728716
54MP0001986_abnormal_taste_sensitivity1.41341523
55MP0001502_abnormal_circadian_rhythm1.38602339
56MP0003045_fibrosis1.37967598
57MP0008058_abnormal_DNA_repair1.37673964
58MP0002638_abnormal_pupillary_reflex1.36700965
59MP0004811_abnormal_neuron_physiology1.36231535
60MP0010234_abnormal_vibrissa_follicle1.36095396
61MP0002735_abnormal_chemical_nociception1.33774998
62MP0002163_abnormal_gland_morphology1.31494038
63MP0003195_calcinosis1.29251420
64MP0001835_abnormal_antigen_presentation1.27684683
65MP0002398_abnormal_bone_marrow1.27612787
66MP0000955_abnormal_spinal_cord1.24909217
67MP0001800_abnormal_humoral_immune1.22868425
68MP0002557_abnormal_social/conspecific_i1.22795100
69MP0003111_abnormal_nucleus_morphology1.21635906
70MP0003077_abnormal_cell_cycle1.21598076
71MP0002184_abnormal_innervation1.21313237
72MP0005310_abnormal_salivary_gland1.17678717
73MP0002166_altered_tumor_susceptibility1.17014078
74MP0001486_abnormal_startle_reflex1.16678016
75MP0000703_abnormal_thymus_morphology1.16227177
76MP0000685_abnormal_immune_system1.16017757
77MP0002067_abnormal_sensory_capabilities1.15983092
78MP0003329_amyloid_beta_deposits1.15770898
79MP0005535_abnormal_body_temperature1.15235984
80MP0003656_abnormal_erythrocyte_physiolo1.14527181
81MP0010678_abnormal_skin_adnexa1.14172123
82MP0010307_abnormal_tumor_latency1.12865352
83MP0005464_abnormal_platelet_physiology1.12468843
84MP0002876_abnormal_thyroid_physiology1.12052869
85MP0002822_catalepsy1.11680972
86MP0004264_abnormal_extraembryonic_tissu1.11346068
87MP0002928_abnormal_bile_duct1.09935650
88MP0003633_abnormal_nervous_system1.09423349
89MP0000689_abnormal_spleen_morphology1.09291586
90MP0001765_abnormal_ion_homeostasis1.08662621
91MP0001984_abnormal_olfaction1.06405112
92MP0003879_abnormal_hair_cell1.05973006
93MP0006276_abnormal_autonomic_nervous1.05709892
94MP0004924_abnormal_behavior1.02387431
95MP0005386_behavior/neurological_phenoty1.02387431
96MP0003943_abnormal_hepatobiliary_system1.01928530
97MP0004885_abnormal_endolymph1.00389547
98MP0001440_abnormal_grooming_behavior0.99979085
99MP0003953_abnormal_hormone_level0.99866047
100MP0002896_abnormal_bone_mineralization0.96972507
101MP0002095_abnormal_skin_pigmentation0.96669347
102MP0004381_abnormal_hair_follicle0.96462069
103MP0005220_abnormal_exocrine_pancreas0.95916702
104MP0002234_abnormal_pharynx_morphology0.95687065
105MP0005423_abnormal_somatic_nervous0.95172955
106MP0005076_abnormal_cell_differentiation0.94823842
107MP0001790_abnormal_immune_system0.94289173
108MP0005387_immune_system_phenotype0.94289173
109MP0001299_abnormal_eye_distance/0.93838048
110MP0000631_abnormal_neuroendocrine_gland0.93361371
111MP0002006_tumorigenesis0.91038054
112MP0002066_abnormal_motor_capabilities/c0.89544140
113MP0002722_abnormal_immune_system0.89325609
114MP0004510_myositis0.89090040
115MP0002069_abnormal_eating/drinking_beha0.88427505
116MP0002882_abnormal_neuron_morphology0.88253811
117MP0008007_abnormal_cellular_replicative0.88182910
118MP0005448_abnormal_energy_balance0.87205831
119MP0000371_diluted_coat_color0.87110402
120MP0005187_abnormal_penis_morphology0.85498537
121MP0002229_neurodegeneration0.85411972
122MP0000427_abnormal_hair_cycle0.84722757
123MP0003634_abnormal_glial_cell0.84477881
124MP0000383_abnormal_hair_follicle0.83219720
125MP0002138_abnormal_hepatobiliary_system0.81841404
126MP0000716_abnormal_immune_system0.80911006
127MP0003303_peritoneal_inflammation0.80515204
128MP0003123_paternal_imprinting0.80362047
129MP0002420_abnormal_adaptive_immunity0.79766506
130MP0005551_abnormal_eye_electrophysiolog0.79555742
131MP0005000_abnormal_immune_tolerance0.78582530
132MP0003121_genomic_imprinting0.78063721
133MP0003868_abnormal_feces_composition0.77499635
134MP0003631_nervous_system_phenotype0.77093325
135MP0009697_abnormal_copulation0.76639086
136MP0001188_hyperpigmentation0.76296694
137MP0008872_abnormal_physiological_respon0.75953269
138MP0002452_abnormal_antigen_presenting0.75925803
139MP0003959_abnormal_lean_body0.73478045
140MP0001819_abnormal_immune_cell0.73431235
141MP0002970_abnormal_white_adipose0.71541472
142MP0003866_abnormal_defecation0.71456991
143MP0002429_abnormal_blood_cell0.71335634
144MP0010352_gastrointestinal_tract_polyps0.70412969
145MP0000778_abnormal_nervous_system0.68457354
146MP0002736_abnormal_nociception_after0.67997298
147MP0001929_abnormal_gametogenesis0.67792879
148MP0002723_abnormal_immune_serum0.66928302
149MP0002075_abnormal_coat/hair_pigmentati0.65678872
150MP0005375_adipose_tissue_phenotype0.65347494
151MP0002152_abnormal_brain_morphology0.64677386
152MP0000350_abnormal_cell_proliferation0.64584937
153MP0001270_distended_abdomen0.64125847
154MP0004145_abnormal_muscle_electrophysio0.63377530
155MP0004130_abnormal_muscle_cell0.63227308
156MP0002751_abnormal_autonomic_nervous0.61969496
157MP0004085_abnormal_heartbeat0.60385699

Predicted human phenotypes

RankGene SetZ-score
1Elevated circulating parathyroid hormone (PTH) level (HP:0003165)6.87665251
2Visual hallucinations (HP:0002367)4.93032698
3Volvulus (HP:0002580)4.72075755
4Papilledema (HP:0001085)4.65485054
5Hyperinsulinemic hypoglycemia (HP:0000825)4.35623168
6Abnormality of calcium-phosphate metabolism (HP:0100530)4.27350417
7Hypoglycemic seizures (HP:0002173)3.89100335
8Gaze-evoked nystagmus (HP:0000640)3.77020450
9Symptomatic seizures (HP:0011145)3.66810845
10Macroorchidism (HP:0000053)3.46776117
11Acute lymphatic leukemia (HP:0006721)3.46032319
12Agitation (HP:0000713)3.40073863
13Focal motor seizures (HP:0011153)3.25834610
14Focal seizures (HP:0007359)3.16747062
15Abnormality of endocrine pancreas physiology (HP:0012093)3.11090456
16Abnormality of the pancreatic islet cells (HP:0006476)3.11090456
17Chromsome breakage (HP:0040012)3.01141018
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98855711
19Truncal ataxia (HP:0002078)2.93015828
20Atonic seizures (HP:0010819)2.92362322
21EEG with generalized epileptiform discharges (HP:0011198)2.89582574
22Hypsarrhythmia (HP:0002521)2.87199281
23Insulin-resistant diabetes mellitus (HP:0000831)2.85190367
24Epileptiform EEG discharges (HP:0011182)2.82150809
25Pancreatic islet-cell hyperplasia (HP:0004510)2.80973958
26Absence seizures (HP:0002121)2.77125267
27Impaired smooth pursuit (HP:0007772)2.73629273
28Acute myeloid leukemia (HP:0004808)2.71153598
29Hyperglycemia (HP:0003074)2.70963090
30Neoplasm of the adrenal cortex (HP:0100641)2.70545875
31Depression (HP:0000716)2.69840005
32Action tremor (HP:0002345)2.64766364
33Large for gestational age (HP:0001520)2.63238406
34Failure to thrive in infancy (HP:0001531)2.62109974
35Decreased circulating renin level (HP:0003351)2.56737965
36Menstrual irregularities (HP:0000858)2.56077534
37Hypercortisolism (HP:0001578)2.55636617
38Dialeptic seizures (HP:0011146)2.54520753
39Hyperventilation (HP:0002883)2.51377896
40Progressive cerebellar ataxia (HP:0002073)2.49044732
41Mucopolysacchariduria (HP:0008155)2.48521970
42Urinary glycosaminoglycan excretion (HP:0003541)2.48521970
43Supranuclear gaze palsy (HP:0000605)2.45562065
44Resting tremor (HP:0002322)2.45328703
45Thyroid carcinoma (HP:0002890)2.43091273
46Febrile seizures (HP:0002373)2.40553923
47Abnormality of chromosome stability (HP:0003220)2.38377518
48Gastrointestinal stroma tumor (HP:0100723)2.35375981
49Hyperparathyroidism (HP:0000843)2.35270794
50Dysostosis multiplex (HP:0000943)2.35115592
51Hypoglycemic coma (HP:0001325)2.31858031
52Genetic anticipation (HP:0003743)2.31664982
53Abnormality of polysaccharide metabolism (HP:0011012)2.29436251
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.29436251
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.29436251
56Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.28980895
57Epileptic encephalopathy (HP:0200134)2.28644860
58Panhypogammaglobulinemia (HP:0003139)2.25937133
59Retinal atrophy (HP:0001105)2.24817350
60Generalized tonic-clonic seizures (HP:0002069)2.24454723
61Renal cortical cysts (HP:0000803)2.23538670
62Ketoacidosis (HP:0001993)2.21351254
63Lower limb hyperreflexia (HP:0002395)2.18265923
64Abnormality of ocular smooth pursuit (HP:0000617)2.17033921
65Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.16795748
66Degeneration of the lateral corticospinal tracts (HP:0002314)2.16795748
67Pheochromocytoma (HP:0002666)2.16699872
68Ankyloglossia (HP:0010296)2.16348987
69Dysautonomia (HP:0002459)2.15795171
70Hypokalemia (HP:0002900)2.14715889
71Agammaglobulinemia (HP:0004432)2.13789179
72Generalized hypopigmentation of hair (HP:0011358)2.13640408
73Increased circulating renin level (HP:0000848)2.10828793
74Impaired vibratory sensation (HP:0002495)2.09705211
75Diplopia (HP:0000651)2.08626814
76Abnormality of binocular vision (HP:0011514)2.08626814
77Anxiety (HP:0000739)2.08606121
78Fair hair (HP:0002286)2.08487226
79Postural tremor (HP:0002174)2.02293941
80Protruding tongue (HP:0010808)2.02066157
81Abnormality of the corticospinal tract (HP:0002492)2.00240095
82Abnormality of chromosome segregation (HP:0002916)1.99338682
83Prolonged bleeding time (HP:0003010)1.99311116
84Urethral obstruction (HP:0000796)1.98950881
85Postural instability (HP:0002172)1.98916167
86Myokymia (HP:0002411)1.98619216
87Abnormal pancreas size (HP:0012094)1.97707573
88Widely spaced teeth (HP:0000687)1.97645395
89Thoracolumbar scoliosis (HP:0002944)1.95769458
90Dysmetric saccades (HP:0000641)1.95615402
91Excessive salivation (HP:0003781)1.95350102
92Drooling (HP:0002307)1.95350102
93Dysdiadochokinesis (HP:0002075)1.95253129
94Abnormality of the renal cortex (HP:0011035)1.94856599
95Constricted visual fields (HP:0001133)1.93088770
96Progressive inability to walk (HP:0002505)1.92257542
97Enlarged penis (HP:0000040)1.91059559
98Global brain atrophy (HP:0002283)1.90738995
99Urinary bladder sphincter dysfunction (HP:0002839)1.89469111
100Abnormality of renin-angiotensin system (HP:0000847)1.89326302
101Neoplasm of the heart (HP:0100544)1.88796108
102Prominent nose (HP:0000448)1.88721072
103Recurrent sinusitis (HP:0011108)1.87947510
104Cutaneous melanoma (HP:0012056)1.85787913
105Insomnia (HP:0100785)1.84330490
106Low anterior hairline (HP:0000294)1.83821083
107Restlessness (HP:0000711)1.83784109
108Late onset (HP:0003584)1.83586558
109Attenuation of retinal blood vessels (HP:0007843)1.83122275
110Limb hypertonia (HP:0002509)1.82572406
111Abnormality of oral frenula (HP:0000190)1.81967046
112Growth hormone excess (HP:0000845)1.81780530
113Absent speech (HP:0001344)1.80448630
114Hemiparesis (HP:0001269)1.80351214
115Psychosis (HP:0000709)1.80211014
116Truncal obesity (HP:0001956)1.79698273
117Abnormality of potassium homeostasis (HP:0011042)1.79682302
118Blue irides (HP:0000635)1.78527516
119Deep palmar crease (HP:0006191)1.78211406
120Cafe-au-lait spot (HP:0000957)1.76715859
121IgM deficiency (HP:0002850)1.76120567
122Bradykinesia (HP:0002067)1.75209786
123Abnormal delayed hypersensitivity skin test (HP:0002963)1.74834077
124Increased CSF protein (HP:0002922)1.74620660
125Hyperphosphatemia (HP:0002905)1.74571992
126Abnormality of the fingertips (HP:0001211)1.74536589
127Obsessive-compulsive behavior (HP:0000722)1.73262436
128Paraplegia (HP:0010550)1.73230330
129Papillary thyroid carcinoma (HP:0002895)1.72186935
130Cutis marmorata (HP:0000965)1.71801866
131Transitional cell carcinoma of the bladder (HP:0006740)1.71751704
132Termporal pattern (HP:0011008)1.71599152
133Insidious onset (HP:0003587)1.71599152
134Thyroiditis (HP:0100646)1.71148342
135Hypomagnesemia (HP:0002917)1.71101314
136Open mouth (HP:0000194)1.70711330
137Absent eyebrow (HP:0002223)1.69776278
138Poor eye contact (HP:0000817)1.69260478
139Vertebral arch anomaly (HP:0008438)1.69051737
140Generalized hyperpigmentation (HP:0007440)1.67770248
141Testicular neoplasm (HP:0010788)1.67733300
142Impaired vibration sensation in the lower limbs (HP:0002166)1.67679169
143Proximal tubulopathy (HP:0000114)1.67580766
144Abnormal social behavior (HP:0012433)1.67140999
145Impaired social interactions (HP:0000735)1.67140999
146Neuroendocrine neoplasm (HP:0100634)1.67100517
147Congenital glaucoma (HP:0001087)1.66735636
148Viral hepatitis (HP:0006562)1.66725929
149Bladder neoplasm (HP:0009725)1.65723298
150Bladder carcinoma (HP:0002862)1.65723298
151Hemiplegia (HP:0002301)1.65650713
152Neuronal loss in central nervous system (HP:0002529)1.65370032
153Hyperkalemia (HP:0002153)1.64982458
154Aplasia/Hypoplasia of the uvula (HP:0010293)1.64465965
155Sandal gap (HP:0001852)1.64399217
156Myelodysplasia (HP:0002863)1.64238414
157Scanning speech (HP:0002168)1.63372082
158Aqueductal stenosis (HP:0002410)1.62510140
159Downturned corners of mouth (HP:0002714)1.61192937
160Abnormality of saccadic eye movements (HP:0000570)1.61019830
161Recurrent cutaneous fungal infections (HP:0011370)1.60505452
162Chronic mucocutaneous candidiasis (HP:0002728)1.60505452
163Abnormality of the astrocytes (HP:0100707)1.59832743
164Astrocytoma (HP:0009592)1.59832743
165Neonatal hypoglycemia (HP:0001998)1.59316479
166Aplasia/Hypoplasia of the fovea (HP:0008060)1.59054306
167Hypoplasia of the fovea (HP:0007750)1.59054306
168Clubbing of toes (HP:0100760)1.58838762
169Abnormal hair whorl (HP:0010721)1.58726280

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR3.62335030
2NTRK33.49667302
3MAP3K93.02440908
4MAP3K22.94915553
5TRPM72.72910913
6PRKD32.69887794
7MAPK152.45736500
8HIPK22.45312648
9FRK2.45034206
10NEK12.36735715
11PASK2.33231218
12EEF2K2.23566070
13SCYL22.18694649
14KSR21.92249995
15NTRK11.89432729
16UHMK11.88501301
17TAOK31.85438754
18MAP3K41.70397228
19EIF2AK31.69285215
20PRKCH1.67335334
21MAP3K141.65585541
22WNK31.63464150
23CAMKK21.58697572
24DAPK21.56488686
25MINK11.54189119
26ACVR1B1.53929054
27MAP3K11.50518286
28TEC1.45859176
29CSF1R1.42284252
30RET1.42158758
31RIPK41.41643149
32CAMKK11.39334366
33YES11.38326732
34MARK11.34328992
35STK31.34004942
36SIK21.33182561
37PAK61.33179383
38FGFR31.31172290
39RIPK11.29978717
40CDC42BPA1.28656390
41CLK11.27609190
42AKT31.27263727
43CAMK1G1.26330621
44MAP2K41.26322940
45NEK21.21358267
46WNK11.21025961
47PAK31.18842758
48PNCK1.16155908
49BTK1.15866590
50ERN11.15542810
51RPS6KB21.14596597
52SGK31.09685807
53SGK21.09253343
54FGFR21.08469324
55CDK51.06990405
56MKNK21.04034470
57BMPR1B1.03903850
58MST41.03667498
59PDGFRA1.03158348
60MAP3K131.03113598
61ALK1.02125647
62WNK41.00869350
63FES0.97296679
64JAK10.96318768
65MAPK130.96038382
66TAF10.93932077
67PRPF4B0.93394671
68MAP2K70.92808056
69KIT0.87664181
70SGK2230.86809801
71SGK4940.86809801
72MAP3K100.86262959
73MAP3K60.84328895
74BRD40.84169169
75TRIB30.82917016
76NTRK20.82704783
77NLK0.81863301
78MARK30.77672374
79GRK50.76331490
80CASK0.76186938
81MAPK110.75743729
82MKNK10.74865804
83ATR0.74277377
84BLK0.73293853
85ERBB30.73033687
86ATM0.72590109
87EIF2AK20.72172066
88NUAK10.71441764
89PLK20.67829587
90KSR10.67012088
91PTK60.66461698
92PTK20.65158486
93STK110.64595709
94MARK20.64554615
95TNK20.64439660
96SYK0.64140395
97PDGFRB0.64131443
98JAK20.64100050
99RPS6KA20.63631782
100PINK10.63446911
101LYN0.60217759
102CDC70.60051942
103CDK120.59623519
104CAMK1D0.59479733
105CHEK10.58583744
106PRKCG0.58316463
107IRAK40.57827956
108SGK10.57647057
109MAPK100.57375470
110OXSR10.56998080
111DAPK10.56856843
112CHEK20.55539683
113MAP2K60.55408703
114DYRK1A0.55374169
115CSNK1D0.55306537
116HCK0.55165414
117PIK3CG0.54093481
118PRKD20.53858649
119STK38L0.51898083
120CAMK2D0.51021167
121PRKCQ0.49760434
122CSNK1G20.49084150
123PDK10.48823655
124CDK60.48716751
125PKN20.48452703
126ARAF0.47535144
127CCNB10.47297375
128STK240.47222461
129SIK30.46911487
130CDK40.46097702
131DYRK1B0.45413900
132BMPR20.44980842
133ITK0.44953745
134BRSK20.44735727
135PRKCE0.44616362
136PRKAA10.43695391
137EPHA40.43610485
138RPS6KA30.43099889
139FYN0.42973842
140STK390.42479180
141EIF2AK10.42103624
142NEK60.41905210
143PRKD10.41079814
144MAP2K10.40913282
145ICK0.40514073
146FLT30.38145491
147FER0.36844202
148EGFR0.36596291
149CAMK2B0.35687541
150CAMK2A0.35497263
151MTOR0.34541922
152MAP4K10.34240233
153RPS6KB10.34195445
154PDPK10.33427271
155STK380.33123129
156IRAK10.32630938

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.91339099
2Insulin secretion_Homo sapiens_hsa049112.84339272
3Non-homologous end-joining_Homo sapiens_hsa034502.78910212
4Type II diabetes mellitus_Homo sapiens_hsa049302.50239185
5Synaptic vesicle cycle_Homo sapiens_hsa047212.14416376
6Long-term potentiation_Homo sapiens_hsa047202.10558125
7Amphetamine addiction_Homo sapiens_hsa050311.97753464
8Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.96508536
9Circadian entrainment_Homo sapiens_hsa047131.93439408
10GABAergic synapse_Homo sapiens_hsa047271.82998035
11Dopaminergic synapse_Homo sapiens_hsa047281.82463447
12Type I diabetes mellitus_Homo sapiens_hsa049401.81285617
13Olfactory transduction_Homo sapiens_hsa047401.76471391
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69536013
15Cocaine addiction_Homo sapiens_hsa050301.67984540
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.66234479
17Carbohydrate digestion and absorption_Homo sapiens_hsa049731.66050300
18Morphine addiction_Homo sapiens_hsa050321.65666542
19Cholinergic synapse_Homo sapiens_hsa047251.62883115
20Glutamatergic synapse_Homo sapiens_hsa047241.60418853
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.59380722
22Nicotine addiction_Homo sapiens_hsa050331.55458956
23Taste transduction_Homo sapiens_hsa047421.55030661
24Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49794882
25Vibrio cholerae infection_Homo sapiens_hsa051101.45917267
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.45546917
27Fanconi anemia pathway_Homo sapiens_hsa034601.35566924
28Primary immunodeficiency_Homo sapiens_hsa053401.33929382
29Estrogen signaling pathway_Homo sapiens_hsa049151.29759284
30Gastric acid secretion_Homo sapiens_hsa049711.28293766
31Renin secretion_Homo sapiens_hsa049241.27981850
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27266224
33Serotonergic synapse_Homo sapiens_hsa047261.27254154
34Lysine degradation_Homo sapiens_hsa003101.27239661
35Platelet activation_Homo sapiens_hsa046111.26562060
36Selenocompound metabolism_Homo sapiens_hsa004501.26551313
37Acute myeloid leukemia_Homo sapiens_hsa052211.24630567
38Dorso-ventral axis formation_Homo sapiens_hsa043201.23696225
39Long-term depression_Homo sapiens_hsa047301.23506585
40Salivary secretion_Homo sapiens_hsa049701.21712400
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.18076213
42Protein export_Homo sapiens_hsa030601.17753137
43Pancreatic secretion_Homo sapiens_hsa049721.13137408
44GnRH signaling pathway_Homo sapiens_hsa049121.12255474
45Measles_Homo sapiens_hsa051621.11388571
46Pancreatic cancer_Homo sapiens_hsa052121.11376773
47Thyroid hormone synthesis_Homo sapiens_hsa049181.08786043
48Oxytocin signaling pathway_Homo sapiens_hsa049211.08770116
49mTOR signaling pathway_Homo sapiens_hsa041501.07447312
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.06648442
51Glucagon signaling pathway_Homo sapiens_hsa049221.04205973
52cAMP signaling pathway_Homo sapiens_hsa040241.02694825
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00783468
54Collecting duct acid secretion_Homo sapiens_hsa049660.99656423
55Glioma_Homo sapiens_hsa052140.98313425
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95261933
57Cell cycle_Homo sapiens_hsa041100.93036816
58Homologous recombination_Homo sapiens_hsa034400.92897382
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.92886854
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92579982
61Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.91311689
62Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90896723
63Inositol phosphate metabolism_Homo sapiens_hsa005620.90553059
64Prolactin signaling pathway_Homo sapiens_hsa049170.90000945
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89171732
66Insulin resistance_Homo sapiens_hsa049310.88320979
67mRNA surveillance pathway_Homo sapiens_hsa030150.87698374
68Gap junction_Homo sapiens_hsa045400.86743321
69Hepatitis B_Homo sapiens_hsa051610.85982756
70ABC transporters_Homo sapiens_hsa020100.85598892
71Basal transcription factors_Homo sapiens_hsa030220.84999315
72Insulin signaling pathway_Homo sapiens_hsa049100.84527137
73Jak-STAT signaling pathway_Homo sapiens_hsa046300.82817308
74Calcium signaling pathway_Homo sapiens_hsa040200.80919696
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.80915946
76ErbB signaling pathway_Homo sapiens_hsa040120.80795786
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.80447313
78Butanoate metabolism_Homo sapiens_hsa006500.80392395
79Herpes simplex infection_Homo sapiens_hsa051680.79316863
80Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78207214
81Sulfur metabolism_Homo sapiens_hsa009200.77505387
82N-Glycan biosynthesis_Homo sapiens_hsa005100.77431514
83Circadian rhythm_Homo sapiens_hsa047100.76618983
84Lysosome_Homo sapiens_hsa041420.76018679
85Melanogenesis_Homo sapiens_hsa049160.71992892
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71589728
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71472568
88Viral carcinogenesis_Homo sapiens_hsa052030.70777297
89MAPK signaling pathway_Homo sapiens_hsa040100.70685236
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.70241770
91Sphingolipid metabolism_Homo sapiens_hsa006000.69864788
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69852251
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.69404326
94Regulation of autophagy_Homo sapiens_hsa041400.67898833
95One carbon pool by folate_Homo sapiens_hsa006700.67780296
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67641779
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67172834
98Renal cell carcinoma_Homo sapiens_hsa052110.66309873
99Endometrial cancer_Homo sapiens_hsa052130.66285911
100Ether lipid metabolism_Homo sapiens_hsa005650.64291543
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64179444
102Non-small cell lung cancer_Homo sapiens_hsa052230.63811926
103B cell receptor signaling pathway_Homo sapiens_hsa046620.62711529
104Alcoholism_Homo sapiens_hsa050340.61973923
105Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.61727051
106Chemokine signaling pathway_Homo sapiens_hsa040620.61121999
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.60835813
108Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60597029
109VEGF signaling pathway_Homo sapiens_hsa043700.60572135
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60193879
111Influenza A_Homo sapiens_hsa051640.59809625
112Endocytosis_Homo sapiens_hsa041440.59772286
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59375422
114Prion diseases_Homo sapiens_hsa050200.58414943
115Glycerophospholipid metabolism_Homo sapiens_hsa005640.57619218
116Choline metabolism in cancer_Homo sapiens_hsa052310.56071917
117Allograft rejection_Homo sapiens_hsa053300.55471259
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55373913
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.55360004
120Glycosaminoglycan degradation_Homo sapiens_hsa005310.53325059
121AMPK signaling pathway_Homo sapiens_hsa041520.52511174
122Chronic myeloid leukemia_Homo sapiens_hsa052200.51531292
123Oocyte meiosis_Homo sapiens_hsa041140.50700056
124T cell receptor signaling pathway_Homo sapiens_hsa046600.50082759
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50075537
126Ras signaling pathway_Homo sapiens_hsa040140.44460939
127Prostate cancer_Homo sapiens_hsa052150.44308370
128FoxO signaling pathway_Homo sapiens_hsa040680.43913468
129Colorectal cancer_Homo sapiens_hsa052100.43471472
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41122619
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.38526896
132Osteoclast differentiation_Homo sapiens_hsa043800.38154812
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37993034
134Adipocytokine signaling pathway_Homo sapiens_hsa049200.36775895
135Tuberculosis_Homo sapiens_hsa051520.36297932

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