TMEFF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.09062326
2axon ensheathment in central nervous system (GO:0032291)9.09062326
3fatty acid elongation (GO:0030497)4.98203978
4establishment of mitochondrion localization (GO:0051654)4.88779391
5myelination (GO:0042552)4.88459962
6ensheathment of neurons (GO:0007272)4.86592328
7axon ensheathment (GO:0008366)4.86592328
8long-chain fatty acid biosynthetic process (GO:0042759)4.77617538
9neuron cell-cell adhesion (GO:0007158)4.72317819
10neuron recognition (GO:0008038)4.43744986
11nucleobase catabolic process (GO:0046113)4.41182694
12paraxial mesoderm development (GO:0048339)4.36940978
13dendritic spine morphogenesis (GO:0060997)4.36587878
14negative regulation of neurotransmitter transport (GO:0051589)4.33961947
15presynaptic membrane organization (GO:0097090)4.25019632
16axonal fasciculation (GO:0007413)4.13504238
17presynaptic membrane assembly (GO:0097105)4.03184418
18apical protein localization (GO:0045176)3.92834876
19planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87874140
20negative regulation of neurotransmitter secretion (GO:0046929)3.81468927
21cerebral cortex radially oriented cell migration (GO:0021799)3.71392307
22layer formation in cerebral cortex (GO:0021819)3.70015427
23regulation of collateral sprouting (GO:0048670)3.66025726
24regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.64359626
25limb bud formation (GO:0060174)3.62757275
26asymmetric protein localization (GO:0008105)3.56889965
27negative regulation of protein localization to cell surface (GO:2000009)3.54460244
28L-amino acid import (GO:0043092)3.49932090
29transmission of nerve impulse (GO:0019226)3.46596294
30convergent extension (GO:0060026)3.43379949
31cell migration in hindbrain (GO:0021535)3.42685885
32myelin maintenance (GO:0043217)3.42309257
33positive regulation of oligodendrocyte differentiation (GO:0048714)3.38400012
34dendrite morphogenesis (GO:0048813)3.37296883
35spinal cord development (GO:0021510)3.35622079
36negative regulation of axonogenesis (GO:0050771)3.32487829
37establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)3.32367669
38mitochondrion transport along microtubule (GO:0047497)3.32082519
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.32082519
40glycerophospholipid catabolic process (GO:0046475)3.28915734
41negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.25478971
42neuron remodeling (GO:0016322)3.25394830
43protein-DNA complex disassembly (GO:0032986)3.25093607
44nucleosome disassembly (GO:0006337)3.25093607
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.20923250
46neuronal action potential propagation (GO:0019227)3.19804760
47protein localization to synapse (GO:0035418)3.19481100
48neuronal stem cell maintenance (GO:0097150)3.19355846
49central nervous system projection neuron axonogenesis (GO:0021952)3.18908888
50regulation of posttranscriptional gene silencing (GO:0060147)3.18665902
51regulation of gene silencing by miRNA (GO:0060964)3.18665902
52regulation of gene silencing by RNA (GO:0060966)3.18665902
53suckling behavior (GO:0001967)3.17265772
54synaptic vesicle maturation (GO:0016188)3.15710116
55cell surface receptor signaling pathway involved in heart development (GO:0061311)3.14325940
56synaptic vesicle exocytosis (GO:0016079)3.13853444
57adult walking behavior (GO:0007628)3.11079879
58substantia nigra development (GO:0021762)3.08866397
59positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.08858621
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.08095228
61pre-miRNA processing (GO:0031054)3.07891504
62oligodendrocyte differentiation (GO:0048709)3.04756325
63negative regulation of axon extension (GO:0030517)3.04511574
64positive regulation of synapse assembly (GO:0051965)3.04269798
65mesenchymal to epithelial transition (GO:0060231)3.03869943
66nerve growth factor signaling pathway (GO:0038180)3.02411499
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02261901
68cholesterol biosynthetic process (GO:0006695)3.00118695
69establishment of nucleus localization (GO:0040023)2.99234943
70glutamate receptor signaling pathway (GO:0007215)2.98288506
71mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.97793980
72regulation of dendritic spine morphogenesis (GO:0061001)2.95728106
73negative regulation of synaptic transmission, GABAergic (GO:0032229)2.95691455
74pyrimidine nucleobase catabolic process (GO:0006208)2.95397928
75axon extension (GO:0048675)2.95000874
76lung-associated mesenchyme development (GO:0060484)2.94822160
77somatic stem cell division (GO:0048103)2.93147166
78establishment of planar polarity (GO:0001736)2.92680291
79establishment of tissue polarity (GO:0007164)2.92680291
80dendritic spine organization (GO:0097061)2.89317433
81regulation of short-term neuronal synaptic plasticity (GO:0048172)2.88330265
82vocalization behavior (GO:0071625)2.88298666
83generation of neurons (GO:0048699)2.87574206
84astrocyte development (GO:0014002)2.87433221
85cytoplasmic mRNA processing body assembly (GO:0033962)2.85965183
86neuronal ion channel clustering (GO:0045161)2.85529001
87establishment or maintenance of bipolar cell polarity (GO:0061245)2.84613927
88establishment or maintenance of apical/basal cell polarity (GO:0035088)2.84613927
89regulation of NFAT protein import into nucleus (GO:0051532)2.83674170
90neuron projection extension involved in neuron projection guidance (GO:1902284)2.82716800
91axon extension involved in axon guidance (GO:0048846)2.82716800
92lens morphogenesis in camera-type eye (GO:0002089)2.81627543
93dendrite development (GO:0016358)2.81221474
94mating behavior (GO:0007617)2.79497555
95gamma-aminobutyric acid signaling pathway (GO:0007214)2.79326463
96regulation of synaptic vesicle exocytosis (GO:2000300)2.78887752
97regulation of axon guidance (GO:1902667)2.78421687
98embryonic retina morphogenesis in camera-type eye (GO:0060059)2.77807030
99forebrain development (GO:0030900)2.77801114
100post-anal tail morphogenesis (GO:0036342)2.76831354
101amino acid import (GO:0043090)2.76750206
102synapse assembly (GO:0007416)2.76543043
103neurotransmitter uptake (GO:0001504)2.74987102
104regulation of axon extension involved in axon guidance (GO:0048841)2.73293243
105central nervous system neuron axonogenesis (GO:0021955)2.72695763
106lateral sprouting from an epithelium (GO:0060601)2.72100821
107organelle transport along microtubule (GO:0072384)2.72082197
108negative regulation of microtubule polymerization (GO:0031115)2.71820651
109neuron-neuron synaptic transmission (GO:0007270)2.70650292
110regulation of growth hormone secretion (GO:0060123)2.70342708
111camera-type eye morphogenesis (GO:0048593)2.70260060
112lens fiber cell development (GO:0070307)2.68683767
113glutamate secretion (GO:0014047)2.68645476
114eye photoreceptor cell differentiation (GO:0001754)2.68573058
115photoreceptor cell differentiation (GO:0046530)2.68573058
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.68217128
117cerebellar granule cell differentiation (GO:0021707)2.67888774
118positive regulation of RNA splicing (GO:0033120)2.67461403
119synaptic transmission, glutamatergic (GO:0035249)2.67069004
120response to methylmercury (GO:0051597)2.66920381
121sterol biosynthetic process (GO:0016126)2.66808456
122dorsal/ventral axis specification (GO:0009950)2.65083056
123regulation of neuronal synaptic plasticity (GO:0048168)2.64325499
124neuron migration (GO:0001764)2.63635563
125negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63169883
126positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.62443966
127positive regulation of cell cycle G2/M phase transition (GO:1902751)2.62443966
128calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.59968776
129exploration behavior (GO:0035640)2.59723076
130axon development (GO:0061564)2.58511035
131regulation of dendritic spine development (GO:0060998)2.58442156
132mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.55641003
133regulation of glutamate receptor signaling pathway (GO:1900449)2.55187203
134Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54718614
135gamma-aminobutyric acid transport (GO:0015812)2.54212976
136regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.53950847
137neurotransmitter-gated ion channel clustering (GO:0072578)2.53546917
138locomotory exploration behavior (GO:0035641)2.52757972
139positive regulation of dendritic spine development (GO:0060999)2.52632386
140isoprenoid biosynthetic process (GO:0008299)2.52454001
141Notch signaling involved in heart development (GO:0061314)2.51904268
142regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51851508
143hindbrain development (GO:0030902)2.51271901
144establishment of integrated proviral latency (GO:0075713)2.50309120
145mRNA stabilization (GO:0048255)2.49577693
146RNA stabilization (GO:0043489)2.49577693
147detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.49351058
148detection of temperature stimulus involved in sensory perception (GO:0050961)2.49351058
149negative regulation of translation, ncRNA-mediated (GO:0040033)2.48157767
150regulation of translation, ncRNA-mediated (GO:0045974)2.48157767
151negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.48157767
152midbrain development (GO:0030901)2.48126054
153neuron projection extension (GO:1990138)2.47967433
154outer ear morphogenesis (GO:0042473)2.47889602
155peptidyl-arginine methylation (GO:0018216)2.47530916
156peptidyl-arginine N-methylation (GO:0035246)2.47530916
157positive regulation of dendritic spine morphogenesis (GO:0061003)2.47343668
158regulation of development, heterochronic (GO:0040034)2.46920173
159postsynaptic membrane organization (GO:0001941)2.46061799
160axonogenesis (GO:0007409)2.45293739
161microtubule polymerization or depolymerization (GO:0031109)2.44885244
162auditory behavior (GO:0031223)2.44855673
163synapse organization (GO:0050808)2.44830284
164ephrin receptor signaling pathway (GO:0048013)2.44226930
165mechanosensory behavior (GO:0007638)2.43143754

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.17679458
2EZH2_22144423_ChIP-Seq_EOC_Human4.77082677
3GBX2_23144817_ChIP-Seq_PC3_Human3.71991227
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.83347404
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73427092
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.66028212
7NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.65024055
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.61431915
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.44143159
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.44143159
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.43413767
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.29185890
13SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.27117153
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.25326934
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.24244212
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22261366
17TAF15_26573619_Chip-Seq_HEK293_Human2.21422763
18SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.16373720
19AR_21572438_ChIP-Seq_LNCaP_Human2.07744209
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07604229
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.07096933
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.04944836
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.03564388
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98980631
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.97518894
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.97192289
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.92801512
28OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91497582
29* REST_21632747_ChIP-Seq_MESCs_Mouse1.87717474
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.86243615
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.85805693
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.84738129
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.80529366
34RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.79461985
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77823562
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.76350142
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74728338
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.73143588
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.72874659
40RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.70465649
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.68736643
42FUS_26573619_Chip-Seq_HEK293_Human1.62218485
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.60794596
44DROSHA_22980978_ChIP-Seq_HELA_Human1.59793912
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.58799667
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.58530614
47RNF2_27304074_Chip-Seq_NSC_Mouse1.52129233
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.50199332
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50019526
50ER_23166858_ChIP-Seq_MCF-7_Human1.47704717
51* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.47690885
52TP63_19390658_ChIP-ChIP_HaCaT_Human1.47415158
53P300_19829295_ChIP-Seq_ESCs_Human1.46845354
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46708360
55* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43285950
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.42967877
57* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.42560456
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41297067
59* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39594449
60VDR_22108803_ChIP-Seq_LS180_Human1.39493119
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.39342268
62ZNF274_21170338_ChIP-Seq_K562_Hela1.31909404
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.31764545
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31616340
65ZFP281_27345836_Chip-Seq_ESCs_Mouse1.31379521
66* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30401278
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30399713
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.29563792
69SMAD4_21799915_ChIP-Seq_A2780_Human1.29180423
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.28515859
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27722625
72SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27566822
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27531874
74RING1B_27294783_Chip-Seq_ESCs_Mouse1.27284721
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.26853992
76POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26759484
77SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26368941
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.26220341
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.26220341
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.26220341
81IGF1R_20145208_ChIP-Seq_DFB_Human1.25603207
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23954719
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23710639
84TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23710639
85SOX9_26525672_Chip-Seq_HEART_Mouse1.23006293
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.22341854
87WT1_19549856_ChIP-ChIP_CCG9911_Human1.21031693
88* NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20005000
89STAT3_23295773_ChIP-Seq_U87_Human1.18385913
90* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.15834828
91* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.15002523
92* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.13962569
93SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12384872
94TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11938485
95SOX2_21211035_ChIP-Seq_LN229_Gbm1.11338921
96ARNT_22903824_ChIP-Seq_MCF-7_Human1.10499141
97P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10269548
98* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.09999898
99* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08826757
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08820467
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08240296
102ESR1_15608294_ChIP-ChIP_MCF-7_Human1.07343364
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06788449
104EWS_26573619_Chip-Seq_HEK293_Human1.06596840
105* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06402865
106* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06297640
107WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05989272
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05468871
109TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05408408
110AHR_22903824_ChIP-Seq_MCF-7_Human1.05088939
111NANOG_16153702_ChIP-ChIP_HESCs_Human1.04547964
112TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02751736
113* TCF4_23295773_ChIP-Seq_U87_Human1.02486059
114NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02476358
115MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01750843
116RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.01174835
117POU5F1_16518401_ChIP-PET_MESCs_Mouse1.01098380
118KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00770242
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.00633443
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.99773336
121RUNX2_22187159_ChIP-Seq_PCA_Human0.99465855
122PRDM14_20953172_ChIP-Seq_ESCs_Human0.99454051
123* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98689472
124SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97772317
125YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97277613
126* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97249606
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96138504
128SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95499287
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94542471
130JUN_21703547_ChIP-Seq_K562_Human0.94147502
131NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94128176
132MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93846021
133AR_25329375_ChIP-Seq_VCAP_Human0.93194055
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.92985177
135SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.92547118
136* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92389991
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92318859
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91955977

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.92885219
2MP0004859_abnormal_synaptic_plasticity3.65361349
3MP0004270_analgesia3.54179341
4MP0000778_abnormal_nervous_system2.98686679
5MP0000920_abnormal_myelination2.97222927
6MP0005423_abnormal_somatic_nervous2.91545092
7MP0003635_abnormal_synaptic_transmissio2.74847686
8MP0001529_abnormal_vocalization2.54035430
9MP0001486_abnormal_startle_reflex2.48693387
10MP0002064_seizures2.37153510
11MP0002063_abnormal_learning/memory/cond2.26845489
12MP0002272_abnormal_nervous_system2.26753017
13MP0004885_abnormal_endolymph2.25855978
14MP0009745_abnormal_behavioral_response2.22894480
15MP0003329_amyloid_beta_deposits2.21521681
16MP0002734_abnormal_mechanical_nocicepti2.15015733
17MP0004742_abnormal_vestibular_system2.02550509
18MP0002572_abnormal_emotion/affect_behav1.96933777
19MP0009046_muscle_twitch1.96065826
20MP0001293_anophthalmia1.89774894
21MP0000955_abnormal_spinal_cord1.88814694
22MP0003283_abnormal_digestive_organ1.88547048
23MP0002697_abnormal_eye_size1.81786553
24MP0001440_abnormal_grooming_behavior1.81629800
25MP0001905_abnormal_dopamine_level1.75030880
26MP0003634_abnormal_glial_cell1.71201255
27MP0005171_absent_coat_pigmentation1.68580155
28MP0001968_abnormal_touch/_nociception1.66415390
29MP0002184_abnormal_innervation1.66265806
30MP0003950_abnormal_plasma_membrane1.62652319
31MP0001485_abnormal_pinna_reflex1.62064285
32MP0004142_abnormal_muscle_tone1.61933704
33MP0002882_abnormal_neuron_morphology1.61459235
34MP0001984_abnormal_olfaction1.60693560
35MP0010030_abnormal_orbit_morphology1.59499527
36MP0002733_abnormal_thermal_nociception1.54519924
37MP0005377_hearing/vestibular/ear_phenot1.53307596
38MP0003878_abnormal_ear_physiology1.53307596
39MP0001970_abnormal_pain_threshold1.53135877
40MP0006276_abnormal_autonomic_nervous1.52118974
41MP0003136_yellow_coat_color1.48455657
42MP0003690_abnormal_glial_cell1.47309268
43MP0005623_abnormal_meninges_morphology1.46796944
44MP0002067_abnormal_sensory_capabilities1.44203337
45MP0003632_abnormal_nervous_system1.43593223
46MP0005386_behavior/neurological_phenoty1.43041601
47MP0004924_abnormal_behavior1.43041601
48MP0005409_darkened_coat_color1.42604540
49MP0002735_abnormal_chemical_nociception1.42315549
50MP0005257_abnormal_intraocular_pressure1.37667282
51MP0005187_abnormal_penis_morphology1.37271172
52MP0002152_abnormal_brain_morphology1.36682907
53MP0002066_abnormal_motor_capabilities/c1.35829262
54MP0006292_abnormal_olfactory_placode1.35813063
55MP0000537_abnormal_urethra_morphology1.35695927
56MP0005248_abnormal_Harderian_gland1.33984152
57MP0009672_abnormal_birth_weight1.33877279
58MP0000462_abnormal_digestive_system1.30699091
59MP0000428_abnormal_craniofacial_morphol1.30573928
60MP0003122_maternal_imprinting1.29024356
61MP0003567_abnormal_fetal_cardiomyocyte1.28350013
62MP0002909_abnormal_adrenal_gland1.28181538
63MP0004811_abnormal_neuron_physiology1.27918878
64MP0002877_abnormal_melanocyte_morpholog1.27504930
65MP0002557_abnormal_social/conspecific_i1.27111056
66MP0009053_abnormal_anal_canal1.27056183
67MP0000566_synostosis1.26351655
68MP0000569_abnormal_digit_pigmentation1.26150856
69MP0003938_abnormal_ear_development1.25550187
70MP0002736_abnormal_nociception_after1.25509896
71MP0002752_abnormal_somatic_nervous1.25434152
72MP0002229_neurodegeneration1.25064747
73MP0001299_abnormal_eye_distance/1.23968575
74MP0001286_abnormal_eye_development1.23839371
75MP0003861_abnormal_nervous_system1.23256900
76MP0002092_abnormal_eye_morphology1.22312306
77MP0004272_abnormal_basement_membrane1.22138073
78MP0003942_abnormal_urinary_system1.20829002
79MP0004134_abnormal_chest_morphology1.20422718
80MP0002081_perinatal_lethality1.18567859
81MP0003631_nervous_system_phenotype1.18394758
82MP0002084_abnormal_developmental_patter1.16541306
83MP0005410_abnormal_fertilization1.15033376
84MP0003935_abnormal_craniofacial_develop1.13866102
85MP0004133_heterotaxia1.13217203
86MP0008569_lethality_at_weaning1.12145223
87MP0003937_abnormal_limbs/digits/tail_de1.10664352
88MP0005645_abnormal_hypothalamus_physiol1.10545299
89MP0001188_hyperpigmentation1.10209030
90MP0000631_abnormal_neuroendocrine_gland1.09604389
91MP0002085_abnormal_embryonic_tissue1.09434994
92MP0001963_abnormal_hearing_physiology1.07518385
93MP0002822_catalepsy1.05871496
94MP0005551_abnormal_eye_electrophysiolog1.04937232
95MP0002638_abnormal_pupillary_reflex1.04593342
96MP0003315_abnormal_perineum_morphology1.03617045
97MP0003633_abnormal_nervous_system1.01265168
98MP0009703_decreased_birth_body1.00763855
99MP0002116_abnormal_craniofacial_bone0.99788904
100MP0006072_abnormal_retinal_apoptosis0.98509928
101MP0002102_abnormal_ear_morphology0.98377035
102MP0002234_abnormal_pharynx_morphology0.98170200
103MP0004145_abnormal_muscle_electrophysio0.98138992
104MP0002653_abnormal_ependyma_morphology0.96536593
105MP0001348_abnormal_lacrimal_gland0.96512489
106MP0003385_abnormal_body_wall0.96063615
107MP0002111_abnormal_tail_morphology0.95901482
108MP0001177_atelectasis0.95387510
109MP0003115_abnormal_respiratory_system0.92296596
110MP0009780_abnormal_chondrocyte_physiolo0.92170383
111MP0005195_abnormal_posterior_eye0.91155679
112MP0000579_abnormal_nail_morphology0.91041748
113MP0008932_abnormal_embryonic_tissue0.90771611
114MP0000026_abnormal_inner_ear0.90481703
115MP0004858_abnormal_nervous_system0.90432408
116MP0009250_abnormal_appendicular_skeleto0.89866443
117MP0010678_abnormal_skin_adnexa0.89107975
118MP0005367_renal/urinary_system_phenotyp0.88984354
119MP0000516_abnormal_urinary_system0.88984354
120MP0002932_abnormal_joint_morphology0.88316305
121MP0001849_ear_inflammation0.87771083
122MP0005391_vision/eye_phenotype0.87663138
123MP0004197_abnormal_fetal_growth/weight/0.87402575
124MP0008789_abnormal_olfactory_epithelium0.87291583
125MP0002751_abnormal_autonomic_nervous0.86536276
126MP0000432_abnormal_head_morphology0.85703181
127MP0003123_paternal_imprinting0.85451867
128MP0003121_genomic_imprinting0.83638165
129MP0003137_abnormal_impulse_conducting0.78297178
130MP0003755_abnormal_palate_morphology0.78295729
131MP0001501_abnormal_sleep_pattern0.77357637
132MP0004043_abnormal_pH_regulation0.77287917
133MP0001943_abnormal_respiration0.76377413
134MP0000604_amyloidosis0.76129098
135MP0000762_abnormal_tongue_morphology0.74807238
136MP0003119_abnormal_digestive_system0.73909133
137MP0000049_abnormal_middle_ear0.73300072
138MP0003787_abnormal_imprinting0.73273336
139MP0002938_white_spotting0.72784742
140MP0000534_abnormal_ureter_morphology0.71675845
141MP0000647_abnormal_sebaceous_gland0.71397527
142MP0003890_abnormal_embryonic-extraembry0.69620537
143MP0005499_abnormal_olfactory_system0.68134679
144MP0005394_taste/olfaction_phenotype0.68134679
145MP0002233_abnormal_nose_morphology0.67560494

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)5.72827742
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.72827742
3Neurofibrillary tangles (HP:0002185)5.07495817
4Abnormality of the corticospinal tract (HP:0002492)4.94510432
5Cerebral inclusion bodies (HP:0100314)4.29078762
6Termporal pattern (HP:0011008)4.11326854
7Insidious onset (HP:0003587)4.11326854
8Myokymia (HP:0002411)3.93570303
9Cortical dysplasia (HP:0002539)3.57620696
10Neonatal short-limb short stature (HP:0008921)3.53503795
11Supranuclear gaze palsy (HP:0000605)3.53002743
12Morphological abnormality of the middle ear (HP:0008609)3.52156519
13Vitreoretinal degeneration (HP:0000655)3.46767250
14Spastic gait (HP:0002064)3.44416569
15Ankle clonus (HP:0011448)3.37812667
16Focal motor seizures (HP:0011153)3.19893812
17Peripheral hypomyelination (HP:0007182)3.18445092
18Sensory axonal neuropathy (HP:0003390)3.05020747
19Alacrima (HP:0000522)2.89807948
20High anterior hairline (HP:0009890)2.81754092
21Cutaneous finger syndactyly (HP:0010554)2.80816440
22Hepatoblastoma (HP:0002884)2.79798850
23Focal seizures (HP:0007359)2.78548293
24Dysmetria (HP:0001310)2.71080526
25Urinary urgency (HP:0000012)2.67674866
26Abnormality of the lower motor neuron (HP:0002366)2.66684234
27Cutaneous syndactyly (HP:0012725)2.65504989
28Retinal dysplasia (HP:0007973)2.63846278
29Anteriorly placed anus (HP:0001545)2.62261746
30Cerebral hypomyelination (HP:0006808)2.58337497
31Vertebral arch anomaly (HP:0008438)2.54218824
32Intention tremor (HP:0002080)2.51949626
33Turricephaly (HP:0000262)2.50167833
34Megalencephaly (HP:0001355)2.48836351
35Scanning speech (HP:0002168)2.47639170
36Parakeratosis (HP:0001036)2.47010871
37Thickened helices (HP:0000391)2.44753411
38Lower limb muscle weakness (HP:0007340)2.44686289
39Trigonocephaly (HP:0000243)2.44485831
40Broad-based gait (HP:0002136)2.41803696
41Onion bulb formation (HP:0003383)2.38821586
42Coronal craniosynostosis (HP:0004440)2.38246861
43Absent septum pellucidum (HP:0001331)2.37484470
44Decreased lacrimation (HP:0000633)2.36008215
45Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.34723827
46Aplasia involving bones of the extremities (HP:0009825)2.32748036
47Aplasia involving bones of the upper limbs (HP:0009823)2.32748036
48Aplasia of the phalanges of the hand (HP:0009802)2.32748036
49Hypoplastic pelvis (HP:0008839)2.30058318
50Mild short stature (HP:0003502)2.28947155
51Epileptic encephalopathy (HP:0200134)2.25893167
52Morphological abnormality of the pyramidal tract (HP:0002062)2.25751751
53Omphalocele (HP:0001539)2.24124755
54Akinesia (HP:0002304)2.23718659
55Increased serum pyruvate (HP:0003542)2.23469551
56Abnormality of glycolysis (HP:0004366)2.23469551
57Limb dystonia (HP:0002451)2.22149093
58Esophageal atresia (HP:0002032)2.21784089
59Calcaneovalgus deformity (HP:0001848)2.21488303
60Excessive salivation (HP:0003781)2.19907416
61Drooling (HP:0002307)2.19907416
62Wide anterior fontanel (HP:0000260)2.18859660
63Abnormality of dentin (HP:0010299)2.16758187
64Atonic seizures (HP:0010819)2.16576728
65Broad long bones (HP:0005622)2.15433143
66Hyperventilation (HP:0002883)2.15428634
67Clumsiness (HP:0002312)2.14457682
68Hemiparesis (HP:0001269)2.14060488
69Genu recurvatum (HP:0002816)2.13901914
70Abnormality of the ischium (HP:0003174)2.12721149
71Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.12351870
72Abnormality of the labia minora (HP:0012880)2.10780600
73Buphthalmos (HP:0000557)2.09550953
74Leukodystrophy (HP:0002415)2.09251714
75Absent speech (HP:0001344)2.08733460
76Abnormality of the septum pellucidum (HP:0007375)2.06934197
77Urinary bladder sphincter dysfunction (HP:0002839)2.06905366
78Choanal stenosis (HP:0000452)2.03605968
79Pheochromocytoma (HP:0002666)2.03063694
80Bronchomalacia (HP:0002780)2.02106586
81Renal hypoplasia (HP:0000089)2.00917315
82Split foot (HP:0001839)1.98329350
83Broad thumb (HP:0011304)1.98289711
84Exotropia (HP:0000577)1.98255022
85Deformed tarsal bones (HP:0008119)1.98162977
86Abnormal auditory evoked potentials (HP:0006958)1.97867204
87Bowel incontinence (HP:0002607)1.97302325
88Intestinal atresia (HP:0011100)1.97107390
89Aplasia/Hypoplasia of the brainstem (HP:0007362)1.96785879
90Hypoplasia of the brainstem (HP:0002365)1.96785879
91Abnormality of the calcaneus (HP:0008364)1.96611426
92Action tremor (HP:0002345)1.96329701
93Amyotrophic lateral sclerosis (HP:0007354)1.95935262
94Progressive cerebellar ataxia (HP:0002073)1.93221439
95Dysdiadochokinesis (HP:0002075)1.91376903
96Clonus (HP:0002169)1.91165164
97Impaired vibration sensation in the lower limbs (HP:0002166)1.90866686
98Mutism (HP:0002300)1.90346310
99Absent eyebrow (HP:0002223)1.88302195
100Increased nuchal translucency (HP:0010880)1.88017380
101Progressive inability to walk (HP:0002505)1.87752632
102Truncal ataxia (HP:0002078)1.86326462
103Generalized hypotonia (HP:0001290)1.85174012
104Aplasia/Hypoplasia of the sternum (HP:0006714)1.84224327
105CNS hypomyelination (HP:0003429)1.82805359
106Dialeptic seizures (HP:0011146)1.82743527
107Shoulder girdle muscle weakness (HP:0003547)1.82624406
108Abnormality of the hip-girdle musculature (HP:0001445)1.82282138
109Abnormality of the musculature of the pelvis (HP:0001469)1.82282138
110Abnormal large intestine physiology (HP:0012700)1.82200561
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82121465
112Short 4th metacarpal (HP:0010044)1.82121465
113Partial agenesis of the corpus callosum (HP:0001338)1.81928629
114Aqueductal stenosis (HP:0002410)1.81823359
115Amblyopia (HP:0000646)1.81107002
116Breech presentation (HP:0001623)1.79976309
117Spastic diplegia (HP:0001264)1.78781710
118Anophthalmia (HP:0000528)1.77546864
119Hammertoe (HP:0001765)1.76844728
120Specific learning disability (HP:0001328)1.76801633
121Shallow orbits (HP:0000586)1.76204981
122Decreased motor nerve conduction velocity (HP:0003431)1.75923890
123Obsessive-compulsive behavior (HP:0000722)1.75604690
124Vaginal atresia (HP:0000148)1.75239803
125Partial duplication of thumb phalanx (HP:0009944)1.74687728
126Lissencephaly (HP:0001339)1.74486674
127Hyperacusis (HP:0010780)1.74407316
128Thin ribs (HP:0000883)1.74379050
129Atrophic scars (HP:0001075)1.74078602
130Bowel diverticulosis (HP:0005222)1.73802450
131Broad phalanx (HP:0006009)1.73263352
132Cupped ear (HP:0000378)1.73119217
133Broad finger (HP:0001500)1.72308477
134Humeroradial synostosis (HP:0003041)1.72300422
135Synostosis involving the elbow (HP:0003938)1.72300422
136Genital tract atresia (HP:0001827)1.72102370
137Broad phalanges of the hand (HP:0009768)1.71910398
138Skull defect (HP:0001362)1.71815822
139Arnold-Chiari malformation (HP:0002308)1.71741056
140Myelomeningocele (HP:0002475)1.71431052
141Hemivertebrae (HP:0002937)1.71174852
142Autoamputation (HP:0001218)1.69621431
143Morphological abnormality of the inner ear (HP:0011390)1.68705960
144Spastic paraplegia (HP:0001258)1.68687220
145Neuroendocrine neoplasm (HP:0100634)1.68552370
146Renovascular hypertension (HP:0100817)1.68318373
147Overriding aorta (HP:0002623)1.67899505
148Abnormality of the phalanges of the 2nd finger (HP:0009541)1.67260455
149Gait imbalance (HP:0002141)1.67050025
150Paraplegia (HP:0010550)1.66237566
151Insomnia (HP:0100785)1.65993897
152Foot dorsiflexor weakness (HP:0009027)1.64251217
153Chin dimple (HP:0010751)1.64092319
154Abnormality of salivation (HP:0100755)1.63955090
155Septo-optic dysplasia (HP:0100842)1.63074892
156Papillary thyroid carcinoma (HP:0002895)1.62229729
157Preaxial foot polydactyly (HP:0001841)1.62087062
158Volvulus (HP:0002580)1.61834251
159Renal duplication (HP:0000075)1.61427752
160Bicornuate uterus (HP:0000813)1.61117374
161Spina bifida occulta (HP:0003298)1.60554114
162Malignant gastrointestinal tract tumors (HP:0006749)1.56768868
163Gastrointestinal carcinoma (HP:0002672)1.56768868
164Optic nerve hypoplasia (HP:0000609)1.56246375
165Abnormality of the pubic bones (HP:0003172)1.56201839
166Ulnar bowing (HP:0003031)1.55715740

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.29180520
2MARK14.25303099
3OXSR12.94145004
4PNCK2.82012117
5BRD42.57048912
6CDK122.40203412
7BCR2.35646142
8EPHA42.33711847
9MAP3K102.13326893
10FGFR22.09446757
11PKN12.06016441
12UHMK12.05441568
13MKNK22.03053704
14DYRK21.96443594
15MAP3K91.88345353
16SRPK11.87581620
17CASK1.80121325
18NTRK11.80021574
19NTRK31.79916471
20PAK61.79034278
21LIMK11.74949653
22EPHB11.70078287
23MAP3K41.65694445
24CSNK1G31.65627407
25FGR1.65561290
26NTRK21.61792109
27TYRO31.57422680
28WNK41.56001262
29CSNK1G21.54823289
30CDK191.54611558
31MAPKAPK51.53064856
32CSNK1A1L1.51365048
33MAPK131.51029442
34TNIK1.49830604
35CDC71.48813093
36RPS6KA41.47644848
37MINK11.44013207
38MET1.43138602
39CAMK2B1.36885688
40ICK1.36394453
41TESK21.30844327
42LATS11.27722291
43PAK31.26279395
44ROCK21.24958988
45CDK51.23971146
46WNK11.21222432
47CSNK1G11.18870426
48KSR11.16898153
49PBK1.14841722
50CDK141.13615680
51TRIM281.10744216
52KSR21.10589839
53MAP2K71.10382719
54PLK21.07055858
55PHKG21.04741882
56PHKG11.04741882
57NEK21.04427403
58CDK151.03890875
59CDK181.01458595
60CAMK2A0.98856209
61CAMK2D0.95543455
62PDGFRA0.95039481
63TAF10.93876813
64MOS0.93857810
65CDK11A0.91635700
66MARK20.91417598
67EPHA30.89358409
68DYRK30.89161310
69STK38L0.87961477
70FGFR10.87761125
71PRPF4B0.87536345
72PKN20.86131683
73NEK60.84234311
74SGK2230.83462189
75SGK4940.83462189
76LATS20.83338173
77YES10.83280500
78MKNK10.82064516
79DAPK20.81300718
80TTK0.80534570
81DYRK1A0.77359492
82DDR20.73201008
83PRKD30.72974342
84WNK30.72568986
85PRKCE0.69637687
86CAMK2G0.65472463
87BMPR1B0.64453409
88CLK10.64201581
89PLK30.64180942
90RIPK10.64030507
91DYRK1B0.63501287
92TSSK60.62843513
93CSNK1D0.62058991
94EPHB20.60095807
95GRK50.59735444
96MAP2K40.59347049
97MUSK0.57064918
98PTK2B0.55961912
99STK110.55825651
100PRKCG0.55025530
101SIK20.52660859
102FYN0.51862022
103CSNK1E0.51817337
104STK240.51187084
105CAMK1D0.51127553
106CAMK1G0.50332413
107ERBB20.49412254
108ERBB30.47441785
109PASK0.47263601
110PRKCZ0.46199398
111CDK90.44842577
112ERBB40.44096390
113PRKDC0.43644448
114ATM0.43462963
115PRKG10.42742781
116MTOR0.42172373
117MAPK90.42171762
118PRKD10.42009790
119PLK40.41063632
120CDK10.40814272
121GSK3B0.40767760
122ATR0.40703713
123MAPK100.40489175
124CDK20.40227227
125MST40.39479338
126PRKACB0.39292319
127SGK20.38667817
128STK30.37552446
129NME10.37510122
130CDK60.37209354
131PAK20.36821406
132PLK10.35748876
133RET0.35598626
134GSK3A0.35380960
135CSNK1A10.33693423
136MAP3K20.33487947
137IRAK20.32087820
138SGK10.32021459
139ALK0.32002861
140CDK30.31629172
141WEE10.31290401
142PRKCQ0.31238971
143ARAF0.30391672
144PDGFRB0.29416128
145ROCK10.29342961

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.94150798
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.76618492
3Steroid biosynthesis_Homo sapiens_hsa001002.76008186
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.73785409
5Nicotine addiction_Homo sapiens_hsa050332.54472453
6Axon guidance_Homo sapiens_hsa043602.54283543
7GABAergic synapse_Homo sapiens_hsa047272.36626623
8Glutamatergic synapse_Homo sapiens_hsa047242.27060449
9Fatty acid elongation_Homo sapiens_hsa000622.19771937
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15335277
11Ether lipid metabolism_Homo sapiens_hsa005652.09679456
12Adherens junction_Homo sapiens_hsa045202.02929188
13Serotonergic synapse_Homo sapiens_hsa047261.90724555
14Morphine addiction_Homo sapiens_hsa050321.90061043
15Circadian entrainment_Homo sapiens_hsa047131.86898476
16Long-term depression_Homo sapiens_hsa047301.86891356
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82118581
18Dopaminergic synapse_Homo sapiens_hsa047281.78550156
19Synaptic vesicle cycle_Homo sapiens_hsa047211.75682756
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.75572623
21mRNA surveillance pathway_Homo sapiens_hsa030151.74840361
22Long-term potentiation_Homo sapiens_hsa047201.64627146
23Spliceosome_Homo sapiens_hsa030401.56988607
24Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55126050
25Oxidative phosphorylation_Homo sapiens_hsa001901.51938427
26Cocaine addiction_Homo sapiens_hsa050301.51271968
27Amphetamine addiction_Homo sapiens_hsa050311.46438804
28Cholinergic synapse_Homo sapiens_hsa047251.45059521
29Renal cell carcinoma_Homo sapiens_hsa052111.40712780
30Gap junction_Homo sapiens_hsa045401.40424370
31Salivary secretion_Homo sapiens_hsa049701.38853845
32Endometrial cancer_Homo sapiens_hsa052131.37237199
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.35148585
34Renin secretion_Homo sapiens_hsa049241.28091062
35Notch signaling pathway_Homo sapiens_hsa043301.27876399
36Alzheimers disease_Homo sapiens_hsa050101.27603157
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.27378217
38Olfactory transduction_Homo sapiens_hsa047401.24884141
39Taste transduction_Homo sapiens_hsa047421.24091101
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.23813210
41Gastric acid secretion_Homo sapiens_hsa049711.22611057
42MicroRNAs in cancer_Homo sapiens_hsa052061.22222731
43Tight junction_Homo sapiens_hsa045301.21442730
44Parkinsons disease_Homo sapiens_hsa050121.21092884
45Cardiac muscle contraction_Homo sapiens_hsa042601.19474950
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.18368131
47Hedgehog signaling pathway_Homo sapiens_hsa043401.18274725
48ErbB signaling pathway_Homo sapiens_hsa040121.11632974
49Collecting duct acid secretion_Homo sapiens_hsa049661.10141900
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09420299
51Cell cycle_Homo sapiens_hsa041101.07950006
52RNA transport_Homo sapiens_hsa030131.06355219
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06093053
54Oxytocin signaling pathway_Homo sapiens_hsa049211.05349319
55Protein digestion and absorption_Homo sapiens_hsa049741.04852410
56Vibrio cholerae infection_Homo sapiens_hsa051101.04595573
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.00732528
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98677592
59Type II diabetes mellitus_Homo sapiens_hsa049300.98470997
60Melanogenesis_Homo sapiens_hsa049160.98153801
61Dorso-ventral axis formation_Homo sapiens_hsa043200.97031808
62Ras signaling pathway_Homo sapiens_hsa040140.95618590
63Alcoholism_Homo sapiens_hsa050340.94936813
64Butanoate metabolism_Homo sapiens_hsa006500.94699461
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.94621078
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.94295049
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.92522818
68Phototransduction_Homo sapiens_hsa047440.91967846
69Wnt signaling pathway_Homo sapiens_hsa043100.89625206
70Insulin secretion_Homo sapiens_hsa049110.89150007
71Vascular smooth muscle contraction_Homo sapiens_hsa042700.88453780
72ECM-receptor interaction_Homo sapiens_hsa045120.88277525
73Thyroid cancer_Homo sapiens_hsa052160.87226059
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.86034085
75Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84284772
76GnRH signaling pathway_Homo sapiens_hsa049120.84252306
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.83908135
78Basal cell carcinoma_Homo sapiens_hsa052170.83520668
79Hippo signaling pathway_Homo sapiens_hsa043900.82956784
80Sphingolipid metabolism_Homo sapiens_hsa006000.79048555
81Huntingtons disease_Homo sapiens_hsa050160.78232343
82Estrogen signaling pathway_Homo sapiens_hsa049150.78203460
83Oocyte meiosis_Homo sapiens_hsa041140.77706265
84Calcium signaling pathway_Homo sapiens_hsa040200.77382591
85Pathways in cancer_Homo sapiens_hsa052000.77204265
86Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76770454
87cAMP signaling pathway_Homo sapiens_hsa040240.76308086
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75532785
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75360673
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74770404
91Non-homologous end-joining_Homo sapiens_hsa034500.74329392
92Biosynthesis of amino acids_Homo sapiens_hsa012300.72745478
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.72711317
94Lysine degradation_Homo sapiens_hsa003100.72047355
95Choline metabolism in cancer_Homo sapiens_hsa052310.70595058
96Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70205027
97TGF-beta signaling pathway_Homo sapiens_hsa043500.69085754
98Vitamin B6 metabolism_Homo sapiens_hsa007500.68966485
99Linoleic acid metabolism_Homo sapiens_hsa005910.68864043
100Endocytosis_Homo sapiens_hsa041440.67517154
101RNA degradation_Homo sapiens_hsa030180.67425912
102Sulfur metabolism_Homo sapiens_hsa009200.65883568
103Mismatch repair_Homo sapiens_hsa034300.64900080
104Focal adhesion_Homo sapiens_hsa045100.64310695
105MAPK signaling pathway_Homo sapiens_hsa040100.64090388
106Glioma_Homo sapiens_hsa052140.63556852
107Proteoglycans in cancer_Homo sapiens_hsa052050.62905720
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62372470
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61900295
110AMPK signaling pathway_Homo sapiens_hsa041520.61333349
111Rap1 signaling pathway_Homo sapiens_hsa040150.61212751
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60503371
113Nitrogen metabolism_Homo sapiens_hsa009100.60409039
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.60290050
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57070159
116Prion diseases_Homo sapiens_hsa050200.56746888
117Melanoma_Homo sapiens_hsa052180.56217564
118Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56052515
119Prostate cancer_Homo sapiens_hsa052150.55949933
120Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55070256
121Insulin signaling pathway_Homo sapiens_hsa049100.54757050
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54645007
123alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53603196
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52852464
125Chronic myeloid leukemia_Homo sapiens_hsa052200.52474438
126Thyroid hormone synthesis_Homo sapiens_hsa049180.52448872
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52138596
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51009438
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50160802
130Pancreatic secretion_Homo sapiens_hsa049720.49110907
131AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48548431
132Ovarian steroidogenesis_Homo sapiens_hsa049130.48357245
133Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.45283738
134Dilated cardiomyopathy_Homo sapiens_hsa054140.44977520
135VEGF signaling pathway_Homo sapiens_hsa043700.44771237
136Prolactin signaling pathway_Homo sapiens_hsa049170.43421562
137DNA replication_Homo sapiens_hsa030300.40286948
138Colorectal cancer_Homo sapiens_hsa052100.39688116
139Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39658156
140Basal transcription factors_Homo sapiens_hsa030220.39612647
141SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39172951
142Phagosome_Homo sapiens_hsa041450.37789914
143Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36891614
144Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36260297
145Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30727398
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30418289

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