TMEM101

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.91716473
2axon ensheathment in central nervous system (GO:0032291)9.91716473
3viral transcription (GO:0019083)7.17682771
4translational termination (GO:0006415)6.85048923
5fatty acid elongation (GO:0030497)6.69340163
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.45295725
7ribosomal small subunit assembly (GO:0000028)6.39608932
8cotranslational protein targeting to membrane (GO:0006613)6.36287500
9protein targeting to ER (GO:0045047)6.30168477
10translational elongation (GO:0006414)6.05800629
11establishment of protein localization to endoplasmic reticulum (GO:0072599)6.03441624
12protein localization to endoplasmic reticulum (GO:0070972)6.00805945
13maturation of SSU-rRNA (GO:0030490)5.70429915
14mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.56539580
15viral life cycle (GO:0019058)5.49346706
16energy coupled proton transport, down electrochemical gradient (GO:0015985)5.39997086
17ATP synthesis coupled proton transport (GO:0015986)5.39997086
18myelination (GO:0042552)5.39490493
19ensheathment of neurons (GO:0007272)5.38057066
20axon ensheathment (GO:0008366)5.38057066
21mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.29492353
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.20491822
23cellular protein complex disassembly (GO:0043624)5.18510948
24cholesterol biosynthetic process (GO:0006695)5.03449508
25translational initiation (GO:0006413)5.03015455
26long-chain fatty acid biosynthetic process (GO:0042759)4.91531151
27ribosomal large subunit biogenesis (GO:0042273)4.88556329
28regulation of mitochondrial translation (GO:0070129)4.57422444
29protein complex disassembly (GO:0043241)4.42571538
30sterol biosynthetic process (GO:0016126)4.39889576
31respiratory electron transport chain (GO:0022904)4.39397339
32translation (GO:0006412)4.39050832
33protein targeting to membrane (GO:0006612)4.38941795
34substantia nigra development (GO:0021762)4.34572406
35protein neddylation (GO:0045116)4.31383331
36electron transport chain (GO:0022900)4.29249666
37macromolecular complex disassembly (GO:0032984)4.27544297
38establishment of mitochondrion localization (GO:0051654)4.21127287
39negative regulation of protein localization to cell surface (GO:2000009)4.20553218
40chaperone-mediated protein transport (GO:0072321)4.20032258
41formation of translation preinitiation complex (GO:0001731)4.15428083
42proteasome assembly (GO:0043248)3.95358597
43regulation of collateral sprouting (GO:0048670)3.92236367
44isoprenoid biosynthetic process (GO:0008299)3.85449847
45negative regulation of neurotransmitter transport (GO:0051589)3.79965563
46oligodendrocyte differentiation (GO:0048709)3.75719028
47presynaptic membrane organization (GO:0097090)3.70020799
48nuclear-transcribed mRNA catabolic process (GO:0000956)3.66041910
49ribonucleoprotein complex biogenesis (GO:0022613)3.65992397
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63682243
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.63682243
52NADH dehydrogenase complex assembly (GO:0010257)3.63682243
53presynaptic membrane assembly (GO:0097105)3.62181916
54L-phenylalanine metabolic process (GO:0006558)3.60530652
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.60530652
56myelin maintenance (GO:0043217)3.60037155
57cellular component biogenesis (GO:0044085)3.57141148
58erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49952406
59L-phenylalanine catabolic process (GO:0006559)3.49952406
60mRNA catabolic process (GO:0006402)3.47820688
61negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.47005195
62GPI anchor biosynthetic process (GO:0006506)3.46753307
63amyloid precursor protein metabolic process (GO:0042982)3.46338231
64response to redox state (GO:0051775)3.43121185
65photoreceptor cell differentiation (GO:0046530)3.43120815
66eye photoreceptor cell differentiation (GO:0001754)3.43120815
67GDP-mannose metabolic process (GO:0019673)3.39900722
68protein targeting to mitochondrion (GO:0006626)3.37356907
69positive regulation of oligodendrocyte differentiation (GO:0048714)3.36525721
70astrocyte development (GO:0014002)3.34413796
71negative regulation of neurotransmitter secretion (GO:0046929)3.33937767
72apical protein localization (GO:0045176)3.33733754
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.32301645
74establishment of protein localization to mitochondrial membrane (GO:0090151)3.31943966
75termination of RNA polymerase III transcription (GO:0006386)3.30810957
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.30810957
77protein maturation by protein folding (GO:0022417)3.29682211
78neuron cell-cell adhesion (GO:0007158)3.28835689
79secondary metabolite biosynthetic process (GO:0044550)3.27406267
80establishment of protein localization to membrane (GO:0090150)3.27028275
81mannosylation (GO:0097502)3.24407995
82establishment of protein localization to mitochondrion (GO:0072655)3.22202447
83melanin biosynthetic process (GO:0042438)3.21940527
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.20358378
85negative regulation of ligase activity (GO:0051352)3.20358378
86protein complex biogenesis (GO:0070271)3.19735080
87GPI anchor metabolic process (GO:0006505)3.18093339
88positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14149588
89rRNA modification (GO:0000154)3.13442658
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13045128
91RNA catabolic process (GO:0006401)3.11759989
92protein targeting (GO:0006605)3.07592754
93regulation of dopamine metabolic process (GO:0042053)3.07013119
94regulation of catecholamine metabolic process (GO:0042069)3.07013119
95protein localization to mitochondrion (GO:0070585)3.06630115
96anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04516246
97limb bud formation (GO:0060174)3.03026473
98regulation of somitogenesis (GO:0014807)3.01329253
99mitochondrial respiratory chain complex assembly (GO:0033108)3.01000955
100regulation of cellular amino acid metabolic process (GO:0006521)3.00683672
101dopamine biosynthetic process (GO:0042416)2.97970273
102long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.97294073
103neural nucleus development (GO:0048857)2.97079013
104L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.95846521
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.94372169
106proline biosynthetic process (GO:0006561)2.93781128
107glycerophospholipid catabolic process (GO:0046475)2.91940323
108preassembly of GPI anchor in ER membrane (GO:0016254)2.91651558
109long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.88060480
110cytochrome complex assembly (GO:0017004)2.87798218
111intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.85860593
112signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.85860593
113spliceosomal snRNP assembly (GO:0000387)2.85664328
114signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.85237284
115signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.85237284
116signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.85237284
117establishment of integrated proviral latency (GO:0075713)2.84344798
118guanosine-containing compound biosynthetic process (GO:1901070)2.83383916
119response to methylmercury (GO:0051597)2.82333095
120galactose catabolic process (GO:0019388)2.80469742
121negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.78726184
122creatine metabolic process (GO:0006600)2.78628502
123establishment of protein localization to organelle (GO:0072594)2.78602685
124asymmetric protein localization (GO:0008105)2.78039454
1257-methylguanosine mRNA capping (GO:0006370)2.77789740
126signal transduction involved in DNA damage checkpoint (GO:0072422)2.76971982
127signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76971982
128protein palmitoylation (GO:0018345)2.76157211
129DNA strand renaturation (GO:0000733)2.75929988
130rRNA processing (GO:0006364)2.74514930
131negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.72230203
132melanin metabolic process (GO:0006582)2.71345112
133signal transduction involved in cell cycle checkpoint (GO:0072395)2.70966655
134positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.70533883
135metallo-sulfur cluster assembly (GO:0031163)2.69011761
136iron-sulfur cluster assembly (GO:0016226)2.69011761
137respiratory chain complex IV assembly (GO:0008535)2.68918498
138cranial nerve development (GO:0021545)2.68480408
139cullin deneddylation (GO:0010388)2.68394723
140rRNA methylation (GO:0031167)2.67822745
1417-methylguanosine RNA capping (GO:0009452)2.67765430
142RNA capping (GO:0036260)2.67765430
143transcription-coupled nucleotide-excision repair (GO:0006283)2.67324590
144amyloid precursor protein catabolic process (GO:0042987)2.67032121
145fatty-acyl-CoA metabolic process (GO:0035337)2.63812685
146peptidyl-histidine modification (GO:0018202)2.63631223
147mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.63568431
148nucleotide transmembrane transport (GO:1901679)2.62153840
149positive regulation of cellular amine metabolic process (GO:0033240)2.59775439
150glial cell development (GO:0021782)2.59338705
151negative regulation of execution phase of apoptosis (GO:1900118)2.59332568
152transmission of nerve impulse (GO:0019226)2.59043512
153microtubule polymerization or depolymerization (GO:0031109)2.58673228
154cerebral cortex radially oriented cell migration (GO:0021799)2.58159163
155tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55412990
156RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55412990
157hydrogen ion transmembrane transport (GO:1902600)2.54565413
158cellular copper ion homeostasis (GO:0006878)2.53869005
159negative regulation of axonogenesis (GO:0050771)2.53817682
160peptidyl-cysteine modification (GO:0018198)2.50269192
161establishment of viral latency (GO:0019043)2.50137749
162cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.50084461
163ATP biosynthetic process (GO:0006754)2.49805189
164neurotransmitter uptake (GO:0001504)2.49322600
165purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.49200764
166negative regulation of axon extension (GO:0030517)2.48089439
167C-terminal protein lipidation (GO:0006501)2.47822432
168GTP biosynthetic process (GO:0006183)2.47085274
169purine nucleoside triphosphate biosynthetic process (GO:0009145)2.46839193
170ribosomal small subunit biogenesis (GO:0042274)2.46777037
171cellular response to epinephrine stimulus (GO:0071872)2.45438029
172ubiquinone metabolic process (GO:0006743)2.45188878
173axon development (GO:0061564)2.44214969
174detection of temperature stimulus involved in sensory perception (GO:0050961)2.44150993
175detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.44150993
176enteric nervous system development (GO:0048484)2.43184396
177neuronal action potential propagation (GO:0019227)2.42307422
178regulation of feeding behavior (GO:0060259)2.41563867
179inner mitochondrial membrane organization (GO:0007007)2.38377317

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.29588746
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39021017
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.35489598
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.29545871
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.23699339
6* GABP_17652178_ChIP-ChIP_JURKAT_Human2.90075097
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79783173
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.72522111
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.60373592
10* EST1_17652178_ChIP-ChIP_JURKAT_Human2.55439161
11* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.46167023
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44275877
13GBX2_23144817_ChIP-Seq_PC3_Human2.43680348
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.41499280
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39703571
16* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37026609
17PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.33338045
18* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30952807
19* GABP_19822575_ChIP-Seq_HepG2_Human2.22261711
20* ETS1_20019798_ChIP-Seq_JURKAT_Human2.13822485
21* FOXP3_21729870_ChIP-Seq_TREG_Human2.10534202
22SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.09358959
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.08195604
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06747820
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02097216
26E2F7_22180533_ChIP-Seq_HELA_Human1.95577252
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.87975388
28EZH2_22144423_ChIP-Seq_EOC_Human1.87440222
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.86478513
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83253518
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.82548297
32FUS_26573619_Chip-Seq_HEK293_Human1.81898079
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.81790366
34VDR_22108803_ChIP-Seq_LS180_Human1.80362440
35JARID2_20064375_ChIP-Seq_MESCs_Mouse1.80264029
36TAF15_26573619_Chip-Seq_HEK293_Human1.80147953
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.75725184
38CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.75347707
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.73748600
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.69961216
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.69243849
42CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.68698488
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66542866
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.65195747
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.63814727
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.63556771
47ZFX_18555785_ChIP-Seq_MESCs_Mouse1.58882775
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58721625
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.56563663
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.55661485
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.50894510
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49946604
53SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.49078007
54POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48402154
55POU5F1_16153702_ChIP-ChIP_HESCs_Human1.48010378
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.46974530
57KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46241050
58KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46241050
59KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46241050
60* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45852312
61FOXM1_23109430_ChIP-Seq_U2OS_Human1.45300721
62MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44867472
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44347010
64HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.44292759
65ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.38774627
66JARID2_20075857_ChIP-Seq_MESCs_Mouse1.37740264
67EZH2_18974828_ChIP-Seq_MESCs_Mouse1.36521542
68RNF2_18974828_ChIP-Seq_MESCs_Mouse1.36521542
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35397188
70NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34606544
71* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33461513
72MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32896346
73* SRF_21415370_ChIP-Seq_HL-1_Mouse1.31834832
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.31526024
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31502797
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29426540
77ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28631122
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.28452823
79ER_23166858_ChIP-Seq_MCF-7_Human1.28055262
80* YY1_21170310_ChIP-Seq_MESCs_Mouse1.27591671
81* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27529964
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.27296003
83SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.26330492
84SUZ12_27294783_Chip-Seq_ESCs_Mouse1.26203334
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25308232
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.25227191
87HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25026524
88BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.24662920
89IRF1_19129219_ChIP-ChIP_H3396_Human1.24090764
90SOX2_16153702_ChIP-ChIP_HESCs_Human1.23186315
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22522398
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21503845
93EOMES_21245162_ChIP-Seq_HESCs_Human1.20778209
94MYC_18358816_ChIP-ChIP_MESCs_Mouse1.20387971
95MTF2_20144788_ChIP-Seq_MESCs_Mouse1.20199207
96SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19954485
97KDM5A_27292631_Chip-Seq_BREAST_Human1.19559567
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19039527
99PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18960017
100ELF1_17652178_ChIP-ChIP_JURKAT_Human1.18757411
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15479330
102DCP1A_22483619_ChIP-Seq_HELA_Human1.14515143
103ZNF263_19887448_ChIP-Seq_K562_Human1.14037110
104E2F1_21310950_ChIP-Seq_MCF-7_Human1.13266594
105TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11626409
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.09911051
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.09746234
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.08187719
109TFEB_21752829_ChIP-Seq_HELA_Human1.08180164
110RNF2_27304074_Chip-Seq_NSC_Mouse1.08021282
111XRN2_22483619_ChIP-Seq_HELA_Human1.06802438
112SMAD3_21741376_ChIP-Seq_EPCs_Human1.06617556
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05639321
114FOXP1_21924763_ChIP-Seq_HESCs_Human1.05540958
115EWS_26573619_Chip-Seq_HEK293_Human1.05005162
116RNF2_27304074_Chip-Seq_ESCs_Mouse1.02790456
117ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02619743
118REST_21632747_ChIP-Seq_MESCs_Mouse1.01746897
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01700324
120* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00168006
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00063045
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99372559
123* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99288438
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.98870645
125STAT3_1855785_ChIP-Seq_MESCs_Mouse0.98708845
126CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.97968413
127* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97258060
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96481937
129MYC_18940864_ChIP-ChIP_HL60_Human0.96401695
130* SOX17_20123909_ChIP-Seq_XEN_Mouse0.96195985
131AR_21572438_ChIP-Seq_LNCaP_Human0.95953823
132* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95702664
133* SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.95341724
134MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.95076034
135ELK1_22589737_ChIP-Seq_MCF10A_Human0.94860526
136EGR1_23403033_ChIP-Seq_LIVER_Mouse0.94783668
137MYC_19030024_ChIP-ChIP_MESCs_Mouse0.94619870
138SOX9_26525672_Chip-Seq_HEART_Mouse0.93222006
139REST_18959480_ChIP-ChIP_MESCs_Mouse0.93008260
140SOX2_18555785_ChIP-Seq_MESCs_Mouse0.92531405
141* VDR_23849224_ChIP-Seq_CD4+_Human0.92019657
142RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91937171
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91935652
144CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.91489629
145P300_19829295_ChIP-Seq_ESCs_Human0.90901162
146TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90700568
147ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.90303477
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89996970
149KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.89699139
150AR_21909140_ChIP-Seq_LNCAP_Human0.88939783
151TTF2_22483619_ChIP-Seq_HELA_Human0.88878799
152LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87938388
153ELK1_19687146_ChIP-ChIP_HELA_Human0.87429443
154SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86805872
155* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86688550
156TET1_21451524_ChIP-Seq_MESCs_Mouse0.86611343
157SRY_22984422_ChIP-ChIP_TESTIS_Rat0.86360256
158PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85392990
159CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85304535
160ZNF274_21170338_ChIP-Seq_K562_Hela0.85221401
161SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85171743
162GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84789014
163REST_19997604_ChIP-ChIP_NEURONS_Mouse0.84401448
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84023835
165* CIITA_25753668_ChIP-Seq_RAJI_Human0.82817344
166FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80142022
167KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79833423

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.84324483
2MP0001529_abnormal_vocalization3.56719627
3MP0000920_abnormal_myelination3.48895404
4MP0003136_yellow_coat_color3.04881479
5MP0001905_abnormal_dopamine_level2.84678893
6MP0006292_abnormal_olfactory_placode2.68138874
7MP0004270_analgesia2.62074748
8MP0005423_abnormal_somatic_nervous2.46239152
9MP0005075_abnormal_melanosome_morpholog2.44121636
10MP0002095_abnormal_skin_pigmentation2.26434783
11MP0003329_amyloid_beta_deposits2.20803515
12MP0000566_synostosis2.20702867
13MP0005171_absent_coat_pigmentation2.18020236
14MP0001485_abnormal_pinna_reflex2.15323888
15MP0003693_abnormal_embryo_hatching2.14054285
16MP0003950_abnormal_plasma_membrane2.13262857
17MP0003186_abnormal_redox_activity2.11475236
18MP0002272_abnormal_nervous_system2.09065143
19MP0004885_abnormal_endolymph2.07767738
20MP0004742_abnormal_vestibular_system2.05396271
21MP0004142_abnormal_muscle_tone2.04822486
22MP0000778_abnormal_nervous_system2.03381221
23MP0010386_abnormal_urinary_bladder1.93213285
24MP0008058_abnormal_DNA_repair1.92414646
25MP0002132_abnormal_respiratory_system1.88858761
26MP0002064_seizures1.85289406
27MP0003634_abnormal_glial_cell1.82976081
28MP0010094_abnormal_chromosome_stability1.82287912
29MP0002160_abnormal_reproductive_system1.81301943
30MP0008875_abnormal_xenobiotic_pharmacok1.77881037
31MP0001293_anophthalmia1.75546480
32MP0002734_abnormal_mechanical_nocicepti1.74245078
33MP0001486_abnormal_startle_reflex1.71630009
34MP0003786_premature_aging1.66509837
35MP0004957_abnormal_blastocyst_morpholog1.64453922
36MP0001324_abnormal_eye_pigmentation1.64317465
37MP0005174_abnormal_tail_pigmentation1.63169205
38MP0000462_abnormal_digestive_system1.62709472
39MP0001968_abnormal_touch/_nociception1.62648086
40MP0002736_abnormal_nociception_after1.62378560
41MP0004381_abnormal_hair_follicle1.56940409
42MP0002938_white_spotting1.55530355
43MP0003635_abnormal_synaptic_transmissio1.55506149
44MP0004133_heterotaxia1.54938928
45MP0009745_abnormal_behavioral_response1.54275336
46MP0003806_abnormal_nucleotide_metabolis1.53981004
47MP0006072_abnormal_retinal_apoptosis1.53932946
48MP0000015_abnormal_ear_pigmentation1.53152320
49MP0004145_abnormal_muscle_electrophysio1.50528953
50MP0005058_abnormal_lysosome_morphology1.50104424
51MP0003690_abnormal_glial_cell1.49168594
52MP0002229_neurodegeneration1.48512753
53MP0000955_abnormal_spinal_cord1.46488794
54MP0010030_abnormal_orbit_morphology1.45356771
55MP0003315_abnormal_perineum_morphology1.44260745
56MP0004043_abnormal_pH_regulation1.43334375
57MP0003122_maternal_imprinting1.42782983
58MP0002572_abnormal_emotion/affect_behav1.42472641
59MP0001440_abnormal_grooming_behavior1.40721700
60MP0003632_abnormal_nervous_system1.38604226
61MP0003077_abnormal_cell_cycle1.38262951
62MP0002234_abnormal_pharynx_morphology1.36590938
63MP0005257_abnormal_intraocular_pressure1.36561990
64MP0006276_abnormal_autonomic_nervous1.36213851
65MP0003938_abnormal_ear_development1.35222876
66MP0001970_abnormal_pain_threshold1.34611511
67MP0002733_abnormal_thermal_nociception1.34353533
68MP0002735_abnormal_chemical_nociception1.34092065
69MP0004272_abnormal_basement_membrane1.33689173
70MP0000371_diluted_coat_color1.32683741
71MP0001963_abnormal_hearing_physiology1.31897959
72MP0004859_abnormal_synaptic_plasticity1.31326087
73MP0009379_abnormal_foot_pigmentation1.30454168
74MP0002882_abnormal_neuron_morphology1.30324047
75MP0002139_abnormal_hepatobiliary_system1.29917408
76MP0002063_abnormal_learning/memory/cond1.27840149
77MP0000358_abnormal_cell_content/1.26791555
78MP0005551_abnormal_eye_electrophysiolog1.25892187
79MP0002752_abnormal_somatic_nervous1.24989081
80MP0009046_muscle_twitch1.22650880
81MP0005197_abnormal_uvea_morphology1.22228463
82MP0004134_abnormal_chest_morphology1.20892852
83MP0004924_abnormal_behavior1.19506960
84MP0005386_behavior/neurological_phenoty1.19506960
85MP0000750_abnormal_muscle_regeneration1.18332859
86MP0000026_abnormal_inner_ear1.17689036
87MP0002066_abnormal_motor_capabilities/c1.15192580
88MP0002067_abnormal_sensory_capabilities1.14187102
89MP0005451_abnormal_body_composition1.12764135
90MP0001186_pigmentation_phenotype1.12450901
91MP0000762_abnormal_tongue_morphology1.10571513
92MP0002697_abnormal_eye_size1.09800256
93MP0002751_abnormal_autonomic_nervous1.09048427
94MP0000749_muscle_degeneration1.08808628
95MP0004036_abnormal_muscle_relaxation1.08663313
96MP0003111_abnormal_nucleus_morphology1.08434396
97MP0002075_abnormal_coat/hair_pigmentati1.08253035
98MP0005085_abnormal_gallbladder_physiolo1.07695167
99MP0000372_irregular_coat_pigmentation1.04923326
100MP0002184_abnormal_innervation1.04821896
101MP0005410_abnormal_fertilization1.02990371
102MP0005365_abnormal_bile_salt1.02729715
103MP0003937_abnormal_limbs/digits/tail_de1.01979896
104MP0008995_early_reproductive_senescence1.00949737
105MP0001346_abnormal_lacrimal_gland0.99776562
106MP0008789_abnormal_olfactory_epithelium0.99701851
107MP0005084_abnormal_gallbladder_morpholo0.99619565
108MP0002152_abnormal_brain_morphology0.98247473
109MP0001986_abnormal_taste_sensitivity0.98112133
110MP0005379_endocrine/exocrine_gland_phen0.98080518
111MP0001299_abnormal_eye_distance/0.96263349
112MP0000049_abnormal_middle_ear0.94792424
113MP0000631_abnormal_neuroendocrine_gland0.93877191
114MP0005253_abnormal_eye_physiology0.93859190
115MP0000751_myopathy0.93743856
116MP0005195_abnormal_posterior_eye0.93253210
117MP0003718_maternal_effect0.91909752
118MP0002277_abnormal_respiratory_mucosa0.90276253
119MP0005623_abnormal_meninges_morphology0.88932157
120MP0003631_nervous_system_phenotype0.88832232
121MP0002102_abnormal_ear_morphology0.88617102
122MP0001881_abnormal_mammary_gland0.88184436
123MP0002092_abnormal_eye_morphology0.86811600
124MP0008569_lethality_at_weaning0.86502737
125MP0005389_reproductive_system_phenotype0.86049988
126MP0005330_cardiomyopathy0.85572154
127MP0001188_hyperpigmentation0.84207854
128MP0008932_abnormal_embryonic_tissue0.83930780
129MP0008007_abnormal_cellular_replicative0.83323665
130MP0000747_muscle_weakness0.82310773
131MP0006036_abnormal_mitochondrial_physio0.82185434
132MP0002210_abnormal_sex_determination0.82140222
133MP0004147_increased_porphyrin_level0.81841292
134MP0005083_abnormal_biliary_tract0.81768778
135MP0003878_abnormal_ear_physiology0.81491721
136MP0005377_hearing/vestibular/ear_phenot0.81491721
137MP0002282_abnormal_trachea_morphology0.80979480
138MP0003861_abnormal_nervous_system0.80096962
139MP0002877_abnormal_melanocyte_morpholog0.79849711
140MP0001727_abnormal_embryo_implantation0.79257583
141MP0006035_abnormal_mitochondrial_morpho0.78505877
142MP0002653_abnormal_ependyma_morphology0.78470567
143MP0005193_abnormal_anterior_eye0.78306731
144MP0002163_abnormal_gland_morphology0.77553040
145MP0003137_abnormal_impulse_conducting0.76949928
146MP0005360_urolithiasis0.76499879
147MP0009250_abnormal_appendicular_skeleto0.75900079
148MP0002837_dystrophic_cardiac_calcinosis0.75745877
149MP0001764_abnormal_homeostasis0.75012252
150MP0001984_abnormal_olfaction0.74299138
151MP0000537_abnormal_urethra_morphology0.74124486
152MP0005332_abnormal_amino_acid0.73400675
153MP0005408_hypopigmentation0.72410778
154MP0009697_abnormal_copulation0.72341694
155MP0002177_abnormal_outer_ear0.71201098
156MP0002557_abnormal_social/conspecific_i0.70939945
157MP0002295_abnormal_pulmonary_circulatio0.70528872
158MP0002233_abnormal_nose_morphology0.68338554
159MP0002249_abnormal_larynx_morphology0.66436774
160MP0001286_abnormal_eye_development0.66124050
161MP0005391_vision/eye_phenotype0.65815995
162MP0001119_abnormal_female_reproductive0.65113735
163MP0001697_abnormal_embryo_size0.64718170
164MP0003385_abnormal_body_wall0.64676356
165MP0002638_abnormal_pupillary_reflex0.64374308
166MP0000653_abnormal_sex_gland0.63624148
167MP0003567_abnormal_fetal_cardiomyocyte0.62234266
168MP0004019_abnormal_vitamin_homeostasis0.61818243
169MP0002090_abnormal_vision0.61487106
170MP0000647_abnormal_sebaceous_gland0.61465404
171MP0005501_abnormal_skin_physiology0.60942946

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.86213611
2Acute necrotizing encephalopathy (HP:0006965)4.74396513
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.67340231
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.67340231
5Abnormality of glycolysis (HP:0004366)4.62463144
6Increased serum pyruvate (HP:0003542)4.62463144
7Neurofibrillary tangles (HP:0002185)4.32759495
8Abnormality of cells of the erythroid lineage (HP:0012130)4.29598957
9Abnormal number of erythroid precursors (HP:0012131)4.15445972
10Mitochondrial inheritance (HP:0001427)4.12205120
11Abnormal mitochondria in muscle tissue (HP:0008316)4.02799882
12Cerebral hypomyelination (HP:0006808)3.83162303
13Acute encephalopathy (HP:0006846)3.80142878
14Progressive macrocephaly (HP:0004481)3.80033124
15Increased hepatocellular lipid droplets (HP:0006565)3.70078360
16Macrocytic anemia (HP:0001972)3.57425985
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.56446690
18Renal Fanconi syndrome (HP:0001994)3.54187168
19Increased muscle lipid content (HP:0009058)3.53619966
20Parakeratosis (HP:0001036)3.52585464
21Increased CSF lactate (HP:0002490)3.49375683
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.47561143
23Decreased activity of mitochondrial respiratory chain (HP:0008972)3.47561143
24Hepatocellular necrosis (HP:0001404)3.46245483
25Type I transferrin isoform profile (HP:0003642)3.44626773
26Leukodystrophy (HP:0002415)3.44583842
27Cerebral inclusion bodies (HP:0100314)3.30939116
28Abnormality of the corticospinal tract (HP:0002492)3.24823881
29Sensory axonal neuropathy (HP:0003390)3.19014941
30Lipid accumulation in hepatocytes (HP:0006561)3.18324742
31Alacrima (HP:0000522)3.06413950
32Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95754905
33Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87603348
34Partial duplication of thumb phalanx (HP:0009944)2.78717565
35Abnormal gallbladder physiology (HP:0012438)2.76466935
36Cholecystitis (HP:0001082)2.76466935
37Peripheral hypomyelination (HP:0007182)2.74229248
38Hepatic necrosis (HP:0002605)2.73457980
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.71882626
40Hypoplastic pelvis (HP:0008839)2.63924090
41CNS hypomyelination (HP:0003429)2.62396660
42Pheochromocytoma (HP:0002666)2.61514189
43Reduced antithrombin III activity (HP:0001976)2.61244450
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.59647517
45Abnormal protein N-linked glycosylation (HP:0012347)2.59647517
46Abnormal protein glycosylation (HP:0012346)2.59647517
47Abnormal glycosylation (HP:0012345)2.59647517
48Vaginal fistula (HP:0004320)2.56571918
49Respiratory failure (HP:0002878)2.55331875
50Cupped ear (HP:0000378)2.52893411
51Pallor (HP:0000980)2.50354070
52Spastic gait (HP:0002064)2.49401686
53Morphological abnormality of the inner ear (HP:0011390)2.47169900
54Rectal fistula (HP:0100590)2.44863415
55Rectovaginal fistula (HP:0000143)2.44863415
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.44205693
57Optic disc pallor (HP:0000543)2.44125581
58Neuroendocrine neoplasm (HP:0100634)2.43569268
59Decreased lacrimation (HP:0000633)2.40473807
60Partial duplication of the phalanx of hand (HP:0009999)2.37155212
61Methylmalonic acidemia (HP:0002912)2.35229023
62Exercise intolerance (HP:0003546)2.34936144
63Pancreatic fibrosis (HP:0100732)2.33745444
64Thickened helices (HP:0000391)2.32511382
65Autoamputation (HP:0001218)2.30688071
66Glycosuria (HP:0003076)2.29581139
67Abnormality of urine glucose concentration (HP:0011016)2.29581139
68Aplastic anemia (HP:0001915)2.28933091
69Hyperglycinemia (HP:0002154)2.28611548
70Patchy hypopigmentation of hair (HP:0011365)2.28002219
71Muscle hypertrophy of the lower extremities (HP:0008968)2.25334166
72White forelock (HP:0002211)2.24793457
73Abnormality of the anterior horn cell (HP:0006802)2.24185464
74Degeneration of anterior horn cells (HP:0002398)2.24185464
75Retinal dysplasia (HP:0007973)2.23134073
76Cerebral edema (HP:0002181)2.22813920
77Increased intramyocellular lipid droplets (HP:0012240)2.22782220
78Anomalous pulmonary venous return (HP:0010772)2.20536770
79Testicular atrophy (HP:0000029)2.20083439
80Generalized aminoaciduria (HP:0002909)2.19494332
81Abnormality of methionine metabolism (HP:0010901)2.19081528
82Supranuclear gaze palsy (HP:0000605)2.18277274
83Hyperphosphaturia (HP:0003109)2.16639767
84Congenital ichthyosiform erythroderma (HP:0007431)2.16535382
85True hermaphroditism (HP:0010459)2.16474390
86Exertional dyspnea (HP:0002875)2.15174922
87Increased serum lactate (HP:0002151)2.14831361
88Cerebral hemorrhage (HP:0001342)2.14183036
893-Methylglutaconic aciduria (HP:0003535)2.13564550
90Renal tubular dysfunction (HP:0000124)2.11660768
91Microvesicular hepatic steatosis (HP:0001414)2.10834159
92Absent septum pellucidum (HP:0001331)2.10172488
93Aplasia involving bones of the extremities (HP:0009825)2.09798260
94Aplasia involving bones of the upper limbs (HP:0009823)2.09798260
95Aplasia of the phalanges of the hand (HP:0009802)2.09798260
96Termporal pattern (HP:0011008)2.07847945
97Insidious onset (HP:0003587)2.07847945
98Postnatal microcephaly (HP:0005484)2.07790737
99Megalencephaly (HP:0001355)2.06774529
100Lethargy (HP:0001254)2.06044408
101Lactic acidosis (HP:0003128)2.04754863
102Myokymia (HP:0002411)2.02064853
103Occipital encephalocele (HP:0002085)1.98415254
104Infantile muscular hypotonia (HP:0008947)1.98048525
105Delusions (HP:0000746)1.97229008
106Medial flaring of the eyebrow (HP:0010747)1.97225530
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.96894030
108Nasolacrimal duct obstruction (HP:0000579)1.96888765
109Esophageal atresia (HP:0002032)1.96418356
110Abnormality of renal resorption (HP:0011038)1.95045700
111Septo-optic dysplasia (HP:0100842)1.95029808
112Exercise-induced muscle cramps (HP:0003710)1.94288553
113Abnormality of reticulocytes (HP:0004312)1.92851393
114X-linked dominant inheritance (HP:0001423)1.92164653
115Asplenia (HP:0001746)1.90777811
116Respiratory difficulties (HP:0002880)1.90698909
117Emotional lability (HP:0000712)1.90250950
118Pancreatic cysts (HP:0001737)1.90054371
119Pancytopenia (HP:0001876)1.87757007
120Abnormality of the phalanges of the 2nd finger (HP:0009541)1.87047737
121Stenosis of the external auditory canal (HP:0000402)1.87043548
122Partial agenesis of the corpus callosum (HP:0001338)1.86791463
123Abnormality of the septum pellucidum (HP:0007375)1.85801831
124Ankle clonus (HP:0011448)1.84787278
125Esophageal neoplasm (HP:0100751)1.82894640
126Neoplasm of head and neck (HP:0012288)1.82894640
127Calf muscle hypertrophy (HP:0008981)1.82551272
128Flat capital femoral epiphysis (HP:0003370)1.82254704
129Vaginal atresia (HP:0000148)1.81926121
130Abnormality of the pulmonary veins (HP:0011718)1.81291492
131Dysmetria (HP:0001310)1.79007518
132Congenital hepatic fibrosis (HP:0002612)1.77943060
133Irregular epiphyses (HP:0010582)1.77109260
134Absent epiphyses (HP:0010577)1.76786023
135Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76786023
136Sclerocornea (HP:0000647)1.76008947
137Abnormality of the fovea (HP:0000493)1.75841096
138Mixed hearing impairment (HP:0000410)1.74549227
139Flattened epiphyses (HP:0003071)1.74534021
140Hypoplastic left heart (HP:0004383)1.74507567
141Akinesia (HP:0002304)1.74192276
142Hyperglycinuria (HP:0003108)1.74091122
143Abnormality of the middle phalanges of the toes (HP:0010183)1.73824930
144Hypoplasia of the fovea (HP:0007750)1.73764684
145Aplasia/Hypoplasia of the fovea (HP:0008060)1.73764684
146Aplasia/Hypoplasia of the macula (HP:0008059)1.73246099
147Spastic paraparesis (HP:0002313)1.73058542
148Premature skin wrinkling (HP:0100678)1.72828978
149Genital tract atresia (HP:0001827)1.72457963
150Epileptic encephalopathy (HP:0200134)1.72417394
151Methylmalonic aciduria (HP:0012120)1.71863144
152Duplication of thumb phalanx (HP:0009942)1.71251376
153Aplasia/Hypoplasia of the spleen (HP:0010451)1.71208176
154Prolonged partial thromboplastin time (HP:0003645)1.70119810
155Double outlet right ventricle (HP:0001719)1.69961301
156Congenital malformation of the right heart (HP:0011723)1.69961301
157Anteriorly placed anus (HP:0001545)1.68553148
158Facial cleft (HP:0002006)1.67905704
159Aplasia/Hypoplasia of the tongue (HP:0010295)1.66959959
160Clumsiness (HP:0002312)1.66623570
161CNS demyelination (HP:0007305)1.66477476
162Secondary amenorrhea (HP:0000869)1.65947741
163Intestinal fistula (HP:0100819)1.65615849
164Abnormal urine phosphate concentration (HP:0012599)1.65096131
165Opisthotonus (HP:0002179)1.63009815
166Progressive muscle weakness (HP:0003323)1.61130858
167Postaxial foot polydactyly (HP:0001830)1.60767993
168Absent thumb (HP:0009777)1.60345050

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.47740051
2NME24.58957747
3STK394.40764216
4BUB13.52241728
5PDK23.37095265
6OXSR13.30922879
7EPHA23.03095812
8CASK2.95952287
9BCKDK2.81496603
10BCR2.72769100
11PBK2.72496059
12CDK192.54963423
13MST42.45709417
14MAPKAPK52.45258963
15NEK12.34960579
16UHMK12.29570361
17EPHB22.26679596
18STK162.24863742
19WEE12.21363443
20ZAK2.20295797
21EIF2AK12.15112475
22LIMK12.08851106
23EPHB12.06459727
24PKN11.99428984
25WNK41.91909137
26PNCK1.89948366
27NEK61.89566257
28FGR1.85478292
29TNIK1.85076849
30CCNB11.82216401
31CSNK1G31.67988600
32DYRK21.67424942
33MET1.66379253
34MST1R1.60132955
35ROCK21.56886103
36CAMK2B1.53116474
37ARAF1.51143342
38NME11.49346931
39EPHA41.43252709
40OBSCN1.43017771
41MKNK11.37406506
42CDC71.30663532
43MUSK1.27886036
44MARK11.25107532
45LRRK21.22652476
46TLK11.22640970
47CHEK21.22555599
48NTRK11.20541999
49PRPF4B1.19571838
50CSNK1A1L1.18984696
51TTK1.18176307
52TESK21.18111512
53VRK11.16429879
54CLK11.14277264
55AURKB1.13619207
56CSNK1G21.13208568
57CAMK2D1.12836823
58CDK71.10751289
59CSNK1G11.09085628
60SMG11.08594154
61ABL21.07923375
62GRK71.07241132
63GRK51.06804031
64WNK11.05949680
65CDK141.05389852
66NEK21.04168649
67BRSK11.01744400
68PLK21.00806236
69NUAK10.98104183
70PLK40.96607815
71MAPK130.91397501
72CDK150.90809114
73MAPKAPK30.89359812
74STK40.89313773
75CDK180.89179553
76PHKG20.88075795
77PHKG10.88075795
78CAMK2A0.87901110
79CDK11A0.87816273
80IRAK30.85696252
81PLK10.82440331
82LMTK20.82273657
83CSNK2A20.82225840
84TIE10.81921775
85ILK0.79299409
86CAMK2G0.77497602
87CDK50.76940424
88MAP3K30.75201501
89RPS6KB20.74178368
90CSNK2A10.73841035
91ATR0.73195425
92BRAF0.72390708
93BMPR1B0.71296121
94MAP2K20.70453185
95FGFR20.67589584
96KDR0.67524087
97MAP3K20.66408464
98ADRBK20.65469731
99PRKCE0.63820465
100CDK40.62771045
101RPS6KA50.62364239
102PAK40.61803816
103MAPK150.60031573
104AKT20.58409404
105ADRBK10.58157035
106TGFBR10.57893924
107TAF10.57306497
108DYRK1A0.56592852
109PAK10.56491469
110MAP4K20.55527886
111MAP3K40.55005182
112EIF2AK30.53666391
113DYRK30.51029284
114ICK0.50918891
115DAPK10.50253648
116FGFR10.50055405
117AURKA0.48913346
118PAK30.48241037
119PLK30.47632188
120SGK4940.46071145
121SGK2230.46071145
122PRKCQ0.45617141
123PRKG10.45499969
124TSSK60.45441339
125DAPK30.45425422
126PAK60.44531098
127BMPR20.43381175
128IKBKB0.43374394
129TYRO30.39774438
130BRSK20.39428897
131MELK0.38622236
132MKNK20.38421302
133PRKCI0.37952221
134NTRK20.37011110
135SRPK10.36922390
136ERBB40.36809598
137PRKACA0.35460464
138MAP2K70.34917805
139CHEK10.34447809
140MOS0.34067626
141PASK0.33452540
142STK30.33141610
143CDK80.32819847
144PIM20.32517468
145PTK2B0.31858231
146EIF2AK20.31619543
147MYLK0.31170477
148TESK10.30247977
149CSNK1A10.30183615
150PRKD30.30175286
151PRKACB0.29766632
152PIK3CA0.29188691
153MARK30.28881163
154PTK20.25780725
155GRK10.25459127

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.80130736
2Oxidative phosphorylation_Homo sapiens_hsa001904.64683724
3Parkinsons disease_Homo sapiens_hsa050123.86793022
4Steroid biosynthesis_Homo sapiens_hsa001003.61408341
5Fatty acid elongation_Homo sapiens_hsa000623.38504301
6Protein export_Homo sapiens_hsa030603.29608152
7Alzheimers disease_Homo sapiens_hsa050103.06755670
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.01063290
9Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.71230433
10Proteasome_Homo sapiens_hsa030502.69183459
11Huntingtons disease_Homo sapiens_hsa050162.63417957
12Ribosome_Homo sapiens_hsa030102.35112747
13Sulfur metabolism_Homo sapiens_hsa009202.19290979
14Ether lipid metabolism_Homo sapiens_hsa005652.18174522
15DNA replication_Homo sapiens_hsa030302.12540921
16Cardiac muscle contraction_Homo sapiens_hsa042602.08954219
17Homologous recombination_Homo sapiens_hsa034402.08052464
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.04313211
19RNA polymerase_Homo sapiens_hsa030201.91640456
20Base excision repair_Homo sapiens_hsa034101.64648823
21Collecting duct acid secretion_Homo sapiens_hsa049661.61975956
22Vibrio cholerae infection_Homo sapiens_hsa051101.47817529
23One carbon pool by folate_Homo sapiens_hsa006701.42061501
24Biosynthesis of amino acids_Homo sapiens_hsa012301.41375071
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36351669
26Sphingolipid metabolism_Homo sapiens_hsa006001.32497741
27Fanconi anemia pathway_Homo sapiens_hsa034601.29493127
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.23148195
29Carbon metabolism_Homo sapiens_hsa012001.22352421
30Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.21683024
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.21308952
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.20224032
33Linoleic acid metabolism_Homo sapiens_hsa005911.17868521
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.16349573
35SNARE interactions in vesicular transport_Homo sapiens_hsa041301.13984952
36Fructose and mannose metabolism_Homo sapiens_hsa000511.13300061
37Pentose phosphate pathway_Homo sapiens_hsa000301.13133010
38Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.12561955
39Basal transcription factors_Homo sapiens_hsa030221.12241120
40Axon guidance_Homo sapiens_hsa043601.10077827
41Serotonergic synapse_Homo sapiens_hsa047261.09557961
42Galactose metabolism_Homo sapiens_hsa000521.08845429
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07873903
44N-Glycan biosynthesis_Homo sapiens_hsa005101.05480742
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.01730903
46Butanoate metabolism_Homo sapiens_hsa006501.01384957
47Vitamin B6 metabolism_Homo sapiens_hsa007500.98339187
48Other glycan degradation_Homo sapiens_hsa005110.94016473
49Peroxisome_Homo sapiens_hsa041460.93967322
50Nicotine addiction_Homo sapiens_hsa050330.92702687
51GABAergic synapse_Homo sapiens_hsa047270.86326313
52alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.86065650
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.85531772
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84683422
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.83771298
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79688285
57Fatty acid degradation_Homo sapiens_hsa000710.79518197
58Glutamatergic synapse_Homo sapiens_hsa047240.78324063
59Arachidonic acid metabolism_Homo sapiens_hsa005900.76745720
60Synaptic vesicle cycle_Homo sapiens_hsa047210.75559319
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75127852
62Spliceosome_Homo sapiens_hsa030400.73504790
63Hedgehog signaling pathway_Homo sapiens_hsa043400.73195133
64Metabolic pathways_Homo sapiens_hsa011000.72731507
65Arginine and proline metabolism_Homo sapiens_hsa003300.72342624
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71177610
67Systemic lupus erythematosus_Homo sapiens_hsa053220.70329437
68Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.69990332
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69271984
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69123607
71Pyruvate metabolism_Homo sapiens_hsa006200.68905879
72Taste transduction_Homo sapiens_hsa047420.68831043
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68289899
74Phenylalanine metabolism_Homo sapiens_hsa003600.67744061
75Fatty acid metabolism_Homo sapiens_hsa012120.66506182
76Long-term depression_Homo sapiens_hsa047300.65965045
77Phototransduction_Homo sapiens_hsa047440.65759800
78Glutathione metabolism_Homo sapiens_hsa004800.64858674
79Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.64778910
80Folate biosynthesis_Homo sapiens_hsa007900.64622730
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.63612895
82Tight junction_Homo sapiens_hsa045300.62930704
83Dopaminergic synapse_Homo sapiens_hsa047280.58832760
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57707824
85Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57643427
86Pyrimidine metabolism_Homo sapiens_hsa002400.57637452
87Histidine metabolism_Homo sapiens_hsa003400.57414753
88Morphine addiction_Homo sapiens_hsa050320.57244885
89Cell cycle_Homo sapiens_hsa041100.56679812
90Starch and sucrose metabolism_Homo sapiens_hsa005000.55261770
91Cocaine addiction_Homo sapiens_hsa050300.54620804
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.54277845
93p53 signaling pathway_Homo sapiens_hsa041150.53693262
94Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52806349
95Rheumatoid arthritis_Homo sapiens_hsa053230.50547814
96Sulfur relay system_Homo sapiens_hsa041220.50452922
97Basal cell carcinoma_Homo sapiens_hsa052170.49702672
98Nucleotide excision repair_Homo sapiens_hsa034200.48200714
99Regulation of autophagy_Homo sapiens_hsa041400.48161623
100Maturity onset diabetes of the young_Homo sapiens_hsa049500.47803443
101Purine metabolism_Homo sapiens_hsa002300.47291209
102Chemical carcinogenesis_Homo sapiens_hsa052040.46932779
103Propanoate metabolism_Homo sapiens_hsa006400.46630033
104Renal cell carcinoma_Homo sapiens_hsa052110.45802610
105Alcoholism_Homo sapiens_hsa050340.45543622
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.45094910
107Phagosome_Homo sapiens_hsa041450.44951563
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.44471984
109Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43060131
110beta-Alanine metabolism_Homo sapiens_hsa004100.42758325
111Circadian entrainment_Homo sapiens_hsa047130.42252934
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42015174
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.41383830
114Amphetamine addiction_Homo sapiens_hsa050310.40721036
115Non-homologous end-joining_Homo sapiens_hsa034500.38034668
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.36393326
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36282804
118RNA degradation_Homo sapiens_hsa030180.35909807
119Complement and coagulation cascades_Homo sapiens_hsa046100.35702547
120Selenocompound metabolism_Homo sapiens_hsa004500.34901806
121Tyrosine metabolism_Homo sapiens_hsa003500.33869083
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33104146
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.31616904
124Prion diseases_Homo sapiens_hsa050200.30837107
125RNA transport_Homo sapiens_hsa030130.30220486
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.29949740
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28995900
128Mismatch repair_Homo sapiens_hsa034300.27915549
129Wnt signaling pathway_Homo sapiens_hsa043100.27692528
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.27685329
131Ras signaling pathway_Homo sapiens_hsa040140.27542466
132Long-term potentiation_Homo sapiens_hsa047200.27524680
133Vitamin digestion and absorption_Homo sapiens_hsa049770.27448911
134Fat digestion and absorption_Homo sapiens_hsa049750.27346593
135Gap junction_Homo sapiens_hsa045400.26252386
136Renin secretion_Homo sapiens_hsa049240.25561082
137Arginine biosynthesis_Homo sapiens_hsa002200.25181827
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.24836892
139Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24821750
140Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.23498196
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.23471099
142Autoimmune thyroid disease_Homo sapiens_hsa053200.23442822
143Melanogenesis_Homo sapiens_hsa049160.23203766
144Mineral absorption_Homo sapiens_hsa049780.22230806
145Cholinergic synapse_Homo sapiens_hsa047250.21457735
146Retinol metabolism_Homo sapiens_hsa008300.20957083
147Lysosome_Homo sapiens_hsa041420.20194736
148Hippo signaling pathway_Homo sapiens_hsa043900.18197063
149Endocytosis_Homo sapiens_hsa041440.17971671
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.17894088
151Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16544740
152Salivary secretion_Homo sapiens_hsa049700.16360756

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