TMEM102

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine metabolic process (GO:0006558)5.88162336
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.88162336
3L-phenylalanine catabolic process (GO:0006559)5.75254739
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.75254739
5interferon-gamma secretion (GO:0072643)5.18733273
6sulfur amino acid catabolic process (GO:0000098)5.17762573
7cysteine metabolic process (GO:0006534)4.90164001
8antigen processing and presentation of endogenous antigen (GO:0019883)4.87157398
9aromatic amino acid family catabolic process (GO:0009074)4.81246938
10positive regulation by symbiont of host defense response (GO:0052509)4.73558770
11modulation by symbiont of host defense response (GO:0052031)4.73558770
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.73558770
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.73558770
14positive regulation by organism of defense response of other organism involved in symbiotic interact4.73558770
15modulation by symbiont of host immune response (GO:0052553)4.73558770
16antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73181987
17antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.72317685
18intestinal cholesterol absorption (GO:0030299)4.62983105
19glyoxylate metabolic process (GO:0046487)4.57566377
20NIK/NF-kappaB signaling (GO:0038061)4.51048177
21serine family amino acid catabolic process (GO:0009071)4.45897791
22cellular glucuronidation (GO:0052695)4.44807362
23antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.44472878
24positive regulation of gamma-delta T cell activation (GO:0046645)4.35730897
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.35413809
26homocysteine metabolic process (GO:0050667)4.13926853
27regulation of interferon-beta biosynthetic process (GO:0045357)4.11259785
28regulation of cell-cell adhesion mediated by cadherin (GO:2000047)4.10313126
29intestinal absorption (GO:0050892)4.07736777
30amino-acid betaine metabolic process (GO:0006577)4.07677887
31urea metabolic process (GO:0019627)4.05621636
32urea cycle (GO:0000050)4.05621636
33tryptophan catabolic process (GO:0006569)4.03559617
34indole-containing compound catabolic process (GO:0042436)4.03559617
35indolalkylamine catabolic process (GO:0046218)4.03559617
36glucuronate metabolic process (GO:0019585)4.03240978
37uronic acid metabolic process (GO:0006063)4.03240978
38negative regulation of erythrocyte differentiation (GO:0045647)4.02075714
39bile acid biosynthetic process (GO:0006699)4.01869789
40detection of bacterium (GO:0016045)4.01450474
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.99112947
42negative regulation of cell killing (GO:0031342)3.99112947
43regulation of cholesterol homeostasis (GO:2000188)3.96020587
44drug catabolic process (GO:0042737)3.94737288
45kynurenine metabolic process (GO:0070189)3.93815678
46detection of other organism (GO:0098543)3.89715110
47drug transmembrane transport (GO:0006855)3.89004262
48serine family amino acid metabolic process (GO:0009069)3.86802405
49macrophage activation involved in immune response (GO:0002281)3.84673565
50nitrogen cycle metabolic process (GO:0071941)3.82900763
51tryptophan metabolic process (GO:0006568)3.82160201
52immunoglobulin mediated immune response (GO:0016064)3.81972351
53urate metabolic process (GO:0046415)3.80736423
54response to peptidoglycan (GO:0032494)3.79507876
55glycine metabolic process (GO:0006544)3.79098241
56fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.77576187
57lysine metabolic process (GO:0006553)3.77364823
58lysine catabolic process (GO:0006554)3.77364823
59aromatic amino acid family metabolic process (GO:0009072)3.76201436
60flavonoid metabolic process (GO:0009812)3.75558084
61drug transport (GO:0015893)3.70641565
62high-density lipoprotein particle remodeling (GO:0034375)3.68287362
63desmosome organization (GO:0002934)3.65167855
64negative regulation of sterol transport (GO:0032372)3.62136332
65negative regulation of cholesterol transport (GO:0032375)3.62136332
66cellular modified amino acid catabolic process (GO:0042219)3.62041917
67phospholipid efflux (GO:0033700)3.61400345
68alpha-linolenic acid metabolic process (GO:0036109)3.60559878
69serine family amino acid biosynthetic process (GO:0009070)3.57975538
70regulation of triglyceride catabolic process (GO:0010896)3.56755380
71alpha-amino acid catabolic process (GO:1901606)3.56492575
72bile acid metabolic process (GO:0008206)3.53931279
73cellular amino acid catabolic process (GO:0009063)3.50758412
74bundle of His cell to Purkinje myocyte communication (GO:0086069)3.49914043
75bile acid and bile salt transport (GO:0015721)3.49777050
76response to nitrosative stress (GO:0051409)3.48346731
77acylglycerol homeostasis (GO:0055090)3.47776235
78triglyceride homeostasis (GO:0070328)3.47776235
79regulation of cholesterol esterification (GO:0010872)3.47100368
80COPI coating of Golgi vesicle (GO:0048205)3.43488808
81Golgi transport vesicle coating (GO:0048200)3.43488808
82folic acid metabolic process (GO:0046655)3.38835289
83reverse cholesterol transport (GO:0043691)3.36844770
84regulation of B cell receptor signaling pathway (GO:0050855)3.36115370
85peptidyl-glutamic acid carboxylation (GO:0017187)3.35985271
86protein carboxylation (GO:0018214)3.35985271
87negative regulation of fibrinolysis (GO:0051918)3.33892968
88imidazole-containing compound metabolic process (GO:0052803)3.33867830
89positive regulation of triglyceride lipase activity (GO:0061365)3.33598111
90positive regulation of lipoprotein lipase activity (GO:0051006)3.33598111
91positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.32552672
92drug metabolic process (GO:0017144)3.31334329
93exogenous drug catabolic process (GO:0042738)3.31070598
94regulation of protein activation cascade (GO:2000257)3.29680987
95intestinal epithelial cell development (GO:0060576)3.25500751
96fatty acid beta-oxidation (GO:0006635)3.24647374
97B cell receptor signaling pathway (GO:0050853)3.23308987
98regulation of bile acid biosynthetic process (GO:0070857)3.22566656
99hormone catabolic process (GO:0042447)3.21098332
100neutrophil activation involved in immune response (GO:0002283)3.20644966
101thymic T cell selection (GO:0045061)3.20050107
102response to muramyl dipeptide (GO:0032495)3.18674826
103organic acid catabolic process (GO:0016054)3.18562517
104carboxylic acid catabolic process (GO:0046395)3.18562517
105leukocyte aggregation (GO:0070486)3.18287122
106positive thymic T cell selection (GO:0045059)3.17548114
107fatty acid oxidation (GO:0019395)3.17237805
108type I interferon signaling pathway (GO:0060337)3.16269044
109cellular response to type I interferon (GO:0071357)3.16269044
110xenobiotic catabolic process (GO:0042178)3.16184468
111response to type I interferon (GO:0034340)3.16111757
112complement activation, alternative pathway (GO:0006957)3.15878069
113carnitine metabolic process (GO:0009437)3.15303494
114proline metabolic process (GO:0006560)3.15103630
115plasma lipoprotein particle assembly (GO:0034377)3.14723874
116response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.13618378
117response to host immune response (GO:0052572)3.13618378
118lipoprotein metabolic process (GO:0042157)3.13128748
119respiratory burst (GO:0045730)3.12662934
120regulation of complement activation (GO:0030449)3.11629266
121cholesterol homeostasis (GO:0042632)3.11596880
122positive regulation of Cdc42 GTPase activity (GO:0043089)3.10178590
123regulation of gamma-delta T cell activation (GO:0046643)3.09608041
124regulation of fibrinolysis (GO:0051917)3.08878153
125glutathione derivative biosynthetic process (GO:1901687)3.08872925
126glutathione derivative metabolic process (GO:1901685)3.08872925
127tyrosine metabolic process (GO:0006570)3.08856908
128short-chain fatty acid metabolic process (GO:0046459)3.08551752
129sterol homeostasis (GO:0055092)3.08353350
130benzene-containing compound metabolic process (GO:0042537)3.08127691
131lipid oxidation (GO:0034440)3.07988529
132negative regulation of fatty acid biosynthetic process (GO:0045717)3.07564215
133myeloid dendritic cell differentiation (GO:0043011)3.06921066
134fatty acid catabolic process (GO:0009062)3.05648269
135glutamate metabolic process (GO:0006536)3.04503921
136fructose metabolic process (GO:0006000)3.04246446
137plasma lipoprotein particle remodeling (GO:0034369)3.03483760
138macromolecular complex remodeling (GO:0034367)3.03483760
139regulation of leukocyte degranulation (GO:0043300)3.00279281
140regulation of mast cell degranulation (GO:0043304)2.96667122
141detection of external biotic stimulus (GO:0098581)2.96199125
142response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.95526601
143response to host (GO:0075136)2.95526601
144response to host defenses (GO:0052200)2.95526601
145negative thymic T cell selection (GO:0045060)2.95182656
146B cell mediated immunity (GO:0019724)2.94048094
147positive regulation of B cell differentiation (GO:0045579)2.90832080
148myeloid dendritic cell activation (GO:0001773)2.90662232
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.88139720
150positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87782827
151lipopolysaccharide-mediated signaling pathway (GO:0031663)2.87745056
152regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86938394
153regulation of T cell tolerance induction (GO:0002664)2.86505142
154negative regulation of interleukin-12 production (GO:0032695)2.85770948
155regulation of gamma-delta T cell differentiation (GO:0045586)2.83580915
156T cell selection (GO:0045058)2.82180027
157regulation of type I interferon-mediated signaling pathway (GO:0060338)2.80660713
158interferon-gamma-mediated signaling pathway (GO:0060333)2.80215753
159negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78460754
160pinocytosis (GO:0006907)2.76264222
161modulation by symbiont of host cellular process (GO:0044068)2.76257694
162negative T cell selection (GO:0043383)2.73642906
163pentose-phosphate shunt (GO:0006098)2.71285401
164germinal center formation (GO:0002467)2.71003145
165regulation of B cell differentiation (GO:0045577)2.70653212
166barbed-end actin filament capping (GO:0051016)2.69071750
167positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.68323499
168regulation of superoxide anion generation (GO:0032928)2.66017084
169positive regulation of interferon-alpha production (GO:0032727)2.65738556
170positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63400479
171mannose metabolic process (GO:0006013)2.61662820
172negative regulation of myeloid cell apoptotic process (GO:0033033)2.61067311
173T cell migration (GO:0072678)2.60181360
174T-helper 1 type immune response (GO:0042088)2.59958778
175tolerance induction (GO:0002507)2.59234734
176regulation of mast cell activation involved in immune response (GO:0033006)2.58724281
177modulation by virus of host process (GO:0019054)2.57734182
178regulation of antigen processing and presentation (GO:0002577)2.56331385
179negative regulation of lymphocyte mediated immunity (GO:0002707)2.56148865
180negative regulation of leukocyte mediated immunity (GO:0002704)2.56130939
181myeloid cell activation involved in immune response (GO:0002275)2.55246617
182regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54277597
183detection of biotic stimulus (GO:0009595)2.54069498
184epithelial cell differentiation involved in prostate gland development (GO:0060742)2.51908666
185positive regulation of antigen processing and presentation (GO:0002579)2.51843749
186regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.49441250
187negative regulation of phagocytosis (GO:0050765)2.48441679
188negative regulation of T cell mediated immunity (GO:0002710)2.48340256
189regulation of tolerance induction (GO:0002643)2.48317013
190regulation of interferon-alpha production (GO:0032647)2.48268158
191cellular extravasation (GO:0045123)2.47969541
192positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46267385
193response to laminar fluid shear stress (GO:0034616)2.45304152
194response to protozoan (GO:0001562)2.44761106
195response to interleukin-15 (GO:0070672)2.44734974
196B cell homeostasis (GO:0001782)2.43957486
197protein localization to endosome (GO:0036010)2.43227712
1983-UTR-mediated mRNA stabilization (GO:0070935)2.41991395
199regulation of defense response to virus by virus (GO:0050690)2.41535414
200glycosphingolipid catabolic process (GO:0046479)2.40734418

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.45304055
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.90345047
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.45660308
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.10645356
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.04313843
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.95894653
7EGR1_23403033_ChIP-Seq_LIVER_Mouse3.89210316
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.49220654
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.40018059
10VDR_21846776_ChIP-Seq_THP-1_Human3.23645544
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.16548872
12MYC_22102868_ChIP-Seq_BL_Human3.06587715
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.03111728
14CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.50196028
15ZNF263_19887448_ChIP-Seq_K562_Human2.47742707
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.40115773
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.32286603
18TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21710726
19ESR1_21235772_ChIP-Seq_MCF-7_Human2.19828662
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.19283046
21VDR_24763502_ChIP-Seq_THP-1_Human2.16706117
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.16691102
23KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.07288272
24SOX2_27498859_Chip-Seq_STOMACH_Mouse2.07059750
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.06830647
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.05195354
27MAF_26560356_Chip-Seq_TH1_Human2.03155339
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human2.02969237
29CLOCK_20551151_ChIP-Seq_293T_Human1.96233456
30TCF7_22412390_ChIP-Seq_EML_Mouse1.94631418
31NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90780380
32ESR2_21235772_ChIP-Seq_MCF-7_Human1.86681482
33TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86483931
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84536687
35KDM2B_26808549_Chip-Seq_DND41_Human1.82316701
36UTX_26944678_Chip-Seq_JUKART_Human1.80491501
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80128729
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.78532337
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.76125300
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.75283200
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74249480
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73918346
43POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.73229048
44MAF_26560356_Chip-Seq_TH2_Human1.71418196
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.71262251
46RUNX1_22412390_ChIP-Seq_EML_Mouse1.71031268
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70565398
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.67465734
49GATA4_25053715_ChIP-Seq_YYC3_Human1.66062312
50* SPI1_23547873_ChIP-Seq_NB4_Human1.63899005
51CDX2_20551321_ChIP-Seq_CACO-2_Human1.62556013
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59514362
53EGR1_19374776_ChIP-ChIP_THP-1_Human1.57231730
54NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.56332205
55GATA6_25053715_ChIP-Seq_YYC3_Human1.54137393
56KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.50875888
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.49366651
58SCL_19346495_ChIP-Seq_HPC-7_Human1.44857387
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.43847837
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.42606932
61DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42397794
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40203546
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40011094
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.38747919
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.37446243
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37189862
67TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.37010544
68P68_20966046_ChIP-Seq_HELA_Human1.35384436
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.33374115
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33300550
71MYB_26560356_Chip-Seq_TH1_Human1.32779240
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.32507071
73GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32053417
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.31464540
75MYB_26560356_Chip-Seq_TH2_Human1.31331360
76SPI1_23127762_ChIP-Seq_K562_Human1.31070357
77NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30608689
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30205812
79* ATF3_27146783_Chip-Seq_COLON_Human1.30051210
80* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29642776
81IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.29367309
82KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29150216
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28670947
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27977485
85SA1_27219007_Chip-Seq_ERYTHROID_Human1.27416120
86RACK7_27058665_Chip-Seq_MCF-7_Human1.26789991
87BCL6_27268052_Chip-Seq_Bcells_Human1.26442145
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.25140655
89STAT6_21828071_ChIP-Seq_BEAS2B_Human1.22902119
90CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22770121
91TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21604760
92ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.21385014
93PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20259469
94SOX2_20726797_ChIP-Seq_SW620_Human1.19872770
95NCOR1_26117541_ChIP-Seq_K562_Human1.18922121
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16164087
97ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15430181
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14999519
99GATA1_19941827_ChIP-Seq_MEL_Mouse1.14413806
100AR_21909140_ChIP-Seq_LNCAP_Human1.14372918
101GATA2_22383799_ChIP-Seq_G1ME_Mouse1.12199957
102GATA1_22025678_ChIP-Seq_K562_Human1.10237219
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.09377199
104CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09158667
105* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09045795
106* KDM2B_26808549_Chip-Seq_JURKAT_Human1.08767976
107* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.08361702
108MYC_18555785_ChIP-Seq_MESCs_Mouse1.06857107
109* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05046186
110* HNF4A_19822575_ChIP-Seq_HepG2_Human1.04995902
111CIITA_25753668_ChIP-Seq_RAJI_Human1.04918316
112NANOG_18555785_ChIP-Seq_MESCs_Mouse1.04402774
113PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04004440
114SMC4_20622854_ChIP-Seq_HELA_Human1.03272969
115HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02075491
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01900006
117* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01655186
118CTCF_26484167_Chip-Seq_Bcells_Mouse1.00815830
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.00384519
120OCT4_18692474_ChIP-Seq_MEFs_Mouse1.00071289
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.99966020
122* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99906093
123BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.99468844
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.99229213
125KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97693793
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97693793
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97693793
128CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.96544596
129STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.96417296
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.95875975
131NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95283854
132P63_26484246_Chip-Seq_KERATINOCYTES_Human0.95041840
133* RARA_24833708_ChIP-Seq_LIVER_Mouse0.95011988
134* CTCF_21964334_Chip-Seq_Bcells_Human0.94750043
135FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94606934
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94602137
137SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93701751
138RUNX_20019798_ChIP-Seq_JUKART_Human0.93643225
139* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.92606969
140TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92553606
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.92463082
142LXR_22292898_ChIP-Seq_THP-1_Human0.92347207
143PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.92338557
144FOXO3_23340844_ChIP-Seq_DLD1_Human0.92142961
145ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91799651
146* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.91347988
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.90372503
148FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89802018
149GATA3_24758297_ChIP-Seq_MCF-7_Human0.89729222
150* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88008547
151ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87753290
152FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87581381
153JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.87304343
154HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87162150
155RXRA_24833708_ChIP-Seq_LIVER_Mouse0.85960541
156TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85381520
157MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85192480
158ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84264660
159RUNX1_27514584_Chip-Seq_MCF-7_Human0.84143031
160CREB1_15753290_ChIP-ChIP_HEK293T_Human0.83832107
161NANOG_18692474_ChIP-Seq_MEFs_Mouse0.82653406
162* TET1_21451524_ChIP-Seq_MESCs_Mouse0.81903607
163NELFA_20434984_ChIP-Seq_ESCs_Mouse0.81131734
164BCOR_27268052_Chip-Seq_Bcells_Human0.80596689
165KLF4_18555785_ChIP-Seq_MESCs_Mouse0.79090881
166NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78555202
167* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.78449603
168FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77945898
169PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77548708
170* CREB1_26743006_Chip-Seq_LNCaP_Human0.77478593
171TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77453051
172* RARB_24833708_ChIP-Seq_LIVER_Mouse0.76778922
173SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74849186
174SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.73559258
175SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.72945642

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.33694946
2MP0005360_urolithiasis6.19735525
3MP0005085_abnormal_gallbladder_physiolo4.75178724
4MP0005365_abnormal_bile_salt4.45229049
5MP0008875_abnormal_xenobiotic_pharmacok3.86359616
6MP0010234_abnormal_vibrissa_follicle3.71079331
7MP0003806_abnormal_nucleotide_metabolis3.70871179
8MP0009840_abnormal_foam_cell3.62245824
9MP0001666_abnormal_nutrient_absorption3.34084352
10MP0001835_abnormal_antigen_presentation3.13734520
11MP0003436_decreased_susceptibility_to3.09540942
12MP0003303_peritoneal_inflammation3.01609622
13MP0003252_abnormal_bile_duct2.79951795
14MP0003195_calcinosis2.77995843
15MP0004019_abnormal_vitamin_homeostasis2.73910365
16MP0001790_abnormal_immune_system2.68357139
17MP0005387_immune_system_phenotype2.68357139
18MP0003763_abnormal_thymus_physiology2.63916131
19MP0005332_abnormal_amino_acid2.58006056
20MP0000685_abnormal_immune_system2.57197695
21MP0010329_abnormal_lipoprotein_level2.56574272
22MP0005671_abnormal_response_to2.48238167
23MP0004264_abnormal_extraembryonic_tissu2.46493550
24MP0005000_abnormal_immune_tolerance2.44832009
25MP0001800_abnormal_humoral_immune2.43758251
26MP0005025_abnormal_response_to2.38488103
27MP0005083_abnormal_biliary_tract2.37131890
28MP0002419_abnormal_innate_immunity2.30620482
29MP0008260_abnormal_autophagy2.26281851
30MP0003300_gastrointestinal_ulcer2.20284132
31MP0002452_abnormal_antigen_presenting2.20281760
32MP0009333_abnormal_splenocyte_physiolog2.16775825
33MP0009785_altered_susceptibility_to2.15142575
34MP0002148_abnormal_hypersensitivity_rea2.14088044
35MP0002723_abnormal_immune_serum2.12567588
36MP0002420_abnormal_adaptive_immunity2.11295070
37MP0001819_abnormal_immune_cell2.09646670
38MP0002796_impaired_skin_barrier2.06641007
39MP0009643_abnormal_urine_homeostasis1.96484411
40MP0002254_reproductive_system_inflammat1.95805683
41MP0003172_abnormal_lysosome_physiology1.94391868
42MP0003724_increased_susceptibility_to1.89158109
43MP0003705_abnormal_hypodermis_morpholog1.86996793
44MP0002138_abnormal_hepatobiliary_system1.84842205
45MP0010155_abnormal_intestine_physiology1.80380999
46MP0002398_abnormal_bone_marrow1.76360555
47MP0002405_respiratory_system_inflammati1.75805825
48MP0005464_abnormal_platelet_physiology1.69392295
49MP0009278_abnormal_bone_marrow1.68247693
50MP0003191_abnormal_cellular_cholesterol1.67576896
51MP0000716_abnormal_immune_system1.67272030
52MP0000609_abnormal_liver_physiology1.62644947
53MP0004043_abnormal_pH_regulation1.61607785
54MP0002118_abnormal_lipid_homeostasis1.60958090
55MP0006082_CNS_inflammation1.58390007
56MP0002396_abnormal_hematopoietic_system1.58190266
57MP0000465_gastrointestinal_hemorrhage1.58025171
58MP0000490_abnormal_crypts_of1.53541480
59MP0001845_abnormal_inflammatory_respons1.51684279
60MP0000858_altered_metastatic_potential1.48597917
61MP0002722_abnormal_immune_system1.47502310
62MP0010678_abnormal_skin_adnexa1.47467199
63MP0001756_abnormal_urination1.45904915
64MP0002429_abnormal_blood_cell1.44729041
65MP0001873_stomach_inflammation1.44595911
66MP0000689_abnormal_spleen_morphology1.43544569
67MP0001533_abnormal_skeleton_physiology1.43059255
68MP0002098_abnormal_vibrissa_morphology1.41859262
69MP0003868_abnormal_feces_composition1.41462137
70MP0010352_gastrointestinal_tract_polyps1.40591489
71MP0005319_abnormal_enzyme/_coenzyme1.38972565
72MP0005310_abnormal_salivary_gland1.37210590
73MP0005084_abnormal_gallbladder_morpholo1.31352731
74MP0000703_abnormal_thymus_morphology1.28498877
75MP0000383_abnormal_hair_follicle1.27891153
76MP0005220_abnormal_exocrine_pancreas1.26446084
77MP0004510_myositis1.24943016
78MP0001764_abnormal_homeostasis1.24619416
79MP0004808_abnormal_hematopoietic_stem1.24547559
80MP0001545_abnormal_hematopoietic_system1.24482884
81MP0005397_hematopoietic_system_phenotyp1.24482884
82MP0003186_abnormal_redox_activity1.22245251
83MP0005636_abnormal_mineral_homeostasis1.21983591
84MP0001851_eye_inflammation1.19093936
85MP0003075_altered_response_to1.17864574
86MP0005076_abnormal_cell_differentiation1.17788852
87MP0002998_abnormal_bone_remodeling1.13536464
88MP0004782_abnormal_surfactant_physiolog1.13080897
89MP0001853_heart_inflammation1.09264292
90MP0002060_abnormal_skin_morphology1.08407884
91MP0005501_abnormal_skin_physiology1.07884066
92MP0002877_abnormal_melanocyte_morpholog1.07626156
93MP0000537_abnormal_urethra_morphology1.05171384
94MP0004185_abnormal_adipocyte_glucose1.04173569
95MP0000462_abnormal_digestive_system0.99660564
96MP0005166_decreased_susceptibility_to0.95312354
97MP0001348_abnormal_lacrimal_gland0.95031790
98MP0001765_abnormal_ion_homeostasis0.94108625
99MP0002132_abnormal_respiratory_system0.94048767
100MP0002136_abnormal_kidney_physiology0.93782963
101MP0005584_abnormal_enzyme/coenzyme_acti0.93453047
102MP0003453_abnormal_keratinocyte_physiol0.92817118
103MP0001216_abnormal_epidermal_layer0.92608084
104MP0000678_abnormal_parathyroid_gland0.91551899
105MP0001944_abnormal_pancreas_morphology0.91349283
106MP0003693_abnormal_embryo_hatching0.91191471
107MP0002166_altered_tumor_susceptibility0.90513560
108MP0005408_hypopigmentation0.90489995
109MP0003718_maternal_effect0.90106298
110MP0003091_abnormal_cell_migration0.90058738
111MP0000598_abnormal_liver_morphology0.88477306
112MP0000343_altered_response_to0.87982523
113MP0002876_abnormal_thyroid_physiology0.87197487
114MP0004381_abnormal_hair_follicle0.85183295
115MP0004233_abnormal_muscle_weight0.84542553
116MP0004858_abnormal_nervous_system0.82280821
117MP0003448_altered_tumor_morphology0.81288407
118MP0002078_abnormal_glucose_homeostasis0.80883593
119MP0000538_abnormal_urinary_bladder0.80572926
120MP0006036_abnormal_mitochondrial_physio0.79558536
121MP0000604_amyloidosis0.78962062
122MP0003828_pulmonary_edema0.78897764
123MP0000377_abnormal_hair_follicle0.77979444
124MP0000613_abnormal_salivary_gland0.76618876
125MP0005451_abnormal_body_composition0.75990096
126MP0009053_abnormal_anal_canal0.75540781
127MP0005670_abnormal_white_adipose0.74800947
128MP0009642_abnormal_blood_homeostasis0.74800687
129MP0003283_abnormal_digestive_organ0.73506233
130MP0005377_hearing/vestibular/ear_phenot0.73438702
131MP0003878_abnormal_ear_physiology0.73438702
132MP0005023_abnormal_wound_healing0.73320956
133MP0000477_abnormal_intestine_morphology0.73272309
134MP0002019_abnormal_tumor_incidence0.71028153
135MP0003315_abnormal_perineum_morphology0.69964234
136MP0001663_abnormal_digestive_system0.69094618
137MP0003866_abnormal_defecation0.68941469
138MP0002277_abnormal_respiratory_mucosa0.68824289
139MP0000467_abnormal_esophagus_morphology0.68192316
140MP0009764_decreased_sensitivity_to0.68025117
141MP0003119_abnormal_digestive_system0.65717973
142MP0002693_abnormal_pancreas_physiology0.65112498
143MP0005395_other_phenotype0.63060589
144MP0001849_ear_inflammation0.62882506
145MP0003566_abnormal_cell_adhesion0.62660655
146MP0000015_abnormal_ear_pigmentation0.62206040
147MP0000427_abnormal_hair_cycle0.61500017
148MP0003795_abnormal_bone_structure0.60969464
149MP0000579_abnormal_nail_morphology0.60854564
150MP0000647_abnormal_sebaceous_gland0.60440523
151MP0003183_abnormal_peptide_metabolism0.59824409
152MP0005058_abnormal_lysosome_morphology0.56755617
153MP0000762_abnormal_tongue_morphology0.56086082
154MP0004947_skin_inflammation0.55421281
155MP0003953_abnormal_hormone_level0.54892499
156MP0003638_abnormal_response/metabolism_0.53850377
157MP0000627_abnormal_mammary_gland0.53473370
158MP0005075_abnormal_melanosome_morpholog0.53038776
159MP0002909_abnormal_adrenal_gland0.52984478
160MP0009379_abnormal_foot_pigmentation0.51194067
161MP0008469_abnormal_protein_level0.50443002
162MP0001881_abnormal_mammary_gland0.49674563
163MP0009765_abnormal_xenobiotic_induced0.49057722
164MP0009763_increased_sensitivity_to0.48615500
165MP0005381_digestive/alimentary_phenotyp0.48389358
166MP0005376_homeostasis/metabolism_phenot0.48050131
167MP0005266_abnormal_metabolism0.47541580
168MP0010771_integument_phenotype0.47117132
169MP0001664_abnormal_digestion0.46392910
170MP0009931_abnormal_skin_appearance0.45972301

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)6.03539368
2Intrahepatic cholestasis (HP:0001406)5.50242446
3Eczematoid dermatitis (HP:0000976)5.36427770
4Abnormality of monocarboxylic acid metabolism (HP:0010996)5.25512312
5Xanthomatosis (HP:0000991)4.97059227
6Hypoglycemic coma (HP:0001325)4.85843740
7Gout (HP:0001997)4.53358469
8Hyperglycinuria (HP:0003108)4.43475072
9Abnormality of macrophages (HP:0004311)4.31289153
10Hypobetalipoproteinemia (HP:0003563)4.30171990
11Recurrent bacterial skin infections (HP:0005406)4.24218182
12Cellulitis (HP:0100658)4.09842095
13Recurrent abscess formation (HP:0002722)4.08946485
14Abnormality of glutamine family amino acid metabolism (HP:0010902)4.01838870
15Deep venous thrombosis (HP:0002625)4.01074789
16Hyperammonemia (HP:0001987)3.98048598
17Ketosis (HP:0001946)3.90620558
18Abnormality of serine family amino acid metabolism (HP:0010894)3.90594221
19Abnormality of glycine metabolism (HP:0010895)3.90594221
20Hyperglycinemia (HP:0002154)3.89431657
21Hyperlipoproteinemia (HP:0010980)3.77112719
22Ketoacidosis (HP:0001993)3.67429187
23Fat malabsorption (HP:0002630)3.59986347
24Mediastinal lymphadenopathy (HP:0100721)3.57293849
25Hypolipoproteinemia (HP:0010981)3.53972013
26Agammaglobulinemia (HP:0004432)3.47410299
27Abnormality of liposaccharide metabolism (HP:0010968)3.44957105
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.44957105
29Abnormality of glycolipid metabolism (HP:0010969)3.44957105
30Abnormality of purine metabolism (HP:0004352)3.44250646
31Abnormality of sulfur amino acid metabolism (HP:0004339)3.44135968
32Prolonged partial thromboplastin time (HP:0003645)3.43300179
33Meningitis (HP:0001287)3.37310962
34Hypoglycemic seizures (HP:0002173)3.35815495
35Malnutrition (HP:0004395)3.35724102
36Late onset (HP:0003584)3.33246954
37Abnormality of aspartate family amino acid metabolism (HP:0010899)3.33030147
38Abnormality of fatty-acid metabolism (HP:0004359)3.29625398
39Hypoalphalipoproteinemia (HP:0003233)3.23840181
40Recurrent viral infections (HP:0004429)3.21336732
41Chronic obstructive pulmonary disease (HP:0006510)3.19498116
42Obstructive lung disease (HP:0006536)3.19498116
43Recurrent fungal infections (HP:0002841)3.18655945
44Colitis (HP:0002583)3.16757728
45Abnormality of nucleobase metabolism (HP:0010932)3.14929523
46Recurrent gram-negative bacterial infections (HP:0005420)3.13184670
47Hyperinsulinemic hypoglycemia (HP:0000825)3.10016401
48Generalized aminoaciduria (HP:0002909)3.08211819
49Right ventricular cardiomyopathy (HP:0011663)3.07716866
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.05957926
51Gastrointestinal stroma tumor (HP:0100723)3.03764680
52Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.00809301
53Dicarboxylic aciduria (HP:0003215)3.00211375
54Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00211375
55Abnormality of the intrinsic pathway (HP:0010989)2.98961249
56Gastrointestinal inflammation (HP:0004386)2.98819628
57Increased IgE level (HP:0003212)2.95756277
58Symptomatic seizures (HP:0011145)2.92156614
59Inflammation of the large intestine (HP:0002037)2.85844296
60Conjugated hyperbilirubinemia (HP:0002908)2.85407577
61Centrally nucleated skeletal muscle fibers (HP:0003687)2.85157908
62Increased cerebral lipofuscin (HP:0011813)2.82647276
63Proximal tubulopathy (HP:0000114)2.81584626
64Delayed CNS myelination (HP:0002188)2.81344528
65Complement deficiency (HP:0004431)2.80082317
66Urticaria (HP:0001025)2.78859281
67Abnormality of methionine metabolism (HP:0010901)2.78270024
68Hyperglycemia (HP:0003074)2.75256419
69Myositis (HP:0100614)2.75120694
70Recurrent skin infections (HP:0001581)2.74969664
71Hyperuricemia (HP:0002149)2.73260240
72Increased purine levels (HP:0004368)2.73260240
73Osteomyelitis (HP:0002754)2.72788204
74Abnormality of the common coagulation pathway (HP:0010990)2.70981563
75Lethargy (HP:0001254)2.70919808
76Gingivitis (HP:0000230)2.69914914
77Epidermoid cyst (HP:0200040)2.69130163
78Ileus (HP:0002595)2.68867858
79Abdominal distention (HP:0003270)2.65709604
80Esophageal varix (HP:0002040)2.64221154
81Abnormality of serum amino acid levels (HP:0003112)2.57128328
82Abnormality of pyrimidine metabolism (HP:0004353)2.56287277
83Elevated erythrocyte sedimentation rate (HP:0003565)2.55237898
84Steatorrhea (HP:0002570)2.52790533
85Orchitis (HP:0100796)2.50385812
86Vasculitis (HP:0002633)2.50072747
87Hyperactive renin-angiotensin system (HP:0000841)2.49848403
88Irritability (HP:0000737)2.46679020
89Abnormality of urine glucose concentration (HP:0011016)2.45137663
90Glycosuria (HP:0003076)2.45137663
91Recurrent cutaneous fungal infections (HP:0011370)2.43268855
92Chronic mucocutaneous candidiasis (HP:0002728)2.43268855
93Dysostosis multiplex (HP:0000943)2.43176232
94Metabolic acidosis (HP:0001942)2.42658108
95Increased neuronal autofluorescent lipopigment (HP:0002074)2.42475242
96Abnormal tarsal ossification (HP:0008369)2.41771959
97Onycholysis (HP:0001806)2.39802915
98Verrucae (HP:0200043)2.39339135
99Papilloma (HP:0012740)2.39339135
100Hepatosplenomegaly (HP:0001433)2.38393865
101Petechiae (HP:0000967)2.33786623
102Abnormal delayed hypersensitivity skin test (HP:0002963)2.32332822
103Hyperbilirubinemia (HP:0002904)2.30858054
104Premature loss of primary teeth (HP:0006323)2.29538729
105Pustule (HP:0200039)2.27344001
106Abnormality of proline metabolism (HP:0010907)2.26273134
107Hydroxyprolinuria (HP:0003080)2.26273134
108Sepsis (HP:0100806)2.23995156
109Hypercholesterolemia (HP:0003124)2.23697304
110Increased serum ferritin (HP:0003281)2.23162276
111Skin ulcer (HP:0200042)2.22500759
112Alkalosis (HP:0001948)2.21739576
113Panhypogammaglobulinemia (HP:0003139)2.19762856
114Pancreatitis (HP:0001733)2.19285746
115Ragged-red muscle fibers (HP:0003200)2.18614170
116Lymphopenia (HP:0001888)2.16234832
117Abnormality of vitamin metabolism (HP:0100508)2.15531726
118Loss of speech (HP:0002371)2.15387361
119Hypertensive crisis (HP:0100735)2.14583495
120Distal lower limb muscle weakness (HP:0009053)2.12151673
121Abnormality of complement system (HP:0005339)2.10344981
122Vascular calcification (HP:0004934)2.10088348
123Stomatitis (HP:0010280)2.09685982
124Polygenic inheritance (HP:0010982)2.09560069
125Abnormality of cells of the lymphoid lineage (HP:0012140)2.08894371
126Purpura (HP:0000979)2.08717518
127Increased IgM level (HP:0003496)2.08648098
128Insulin resistance (HP:0000855)2.08300737
129Recurrent bronchitis (HP:0002837)2.07668894
130Restrictive lung disease (HP:0002091)2.07513402
131Vomiting (HP:0002013)2.06990940
132Joint hemorrhage (HP:0005261)2.06492255
133Granulocytopenia (HP:0001913)2.04891230
134Abnormality of chloride homeostasis (HP:0011422)2.04377875
135Axonal loss (HP:0003447)2.04343768
136Hepatocellular carcinoma (HP:0001402)2.03133381
137Sensorimotor neuropathy (HP:0007141)2.01817318
138Fragile nails (HP:0001808)2.01646494
139Retrobulbar optic neuritis (HP:0100654)2.01067492
140Optic neuritis (HP:0100653)2.01067492
141Emphysema (HP:0002097)2.00753746
142Milia (HP:0001056)2.00280369
143Protuberant abdomen (HP:0001538)1.96857522
144Gastrointestinal infarctions (HP:0005244)1.96061214
145Skin rash (HP:0000988)1.95739121
146Spontaneous hematomas (HP:0007420)1.95697026
147Nephrolithiasis (HP:0000787)1.93771179
148Abnormal enzyme/coenzyme activity (HP:0012379)1.93578144
149Systemic lupus erythematosus (HP:0002725)1.92904650
150Thoracic kyphosis (HP:0002942)1.92721942
151Abnormality of endocrine pancreas physiology (HP:0012093)1.92411857
152Abnormality of the pancreatic islet cells (HP:0006476)1.92411857
153Abnormal blistering of the skin (HP:0008066)1.91156979
154Spastic diplegia (HP:0001264)1.90829008
155Abnormal cartilage morphology (HP:0002763)1.89781667
156Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.89129841
157Upper motor neuron abnormality (HP:0002127)1.88890129
158Encephalitis (HP:0002383)1.88653496
159Rickets (HP:0002748)1.86429453
160Neonatal onset (HP:0003623)1.86397573
161Alopecia of scalp (HP:0002293)1.86246742
162Glomerulosclerosis (HP:0000096)1.86114744
163Abnormality of T cell physiology (HP:0011840)1.85929676
164Interstitial pulmonary disease (HP:0006530)1.85795432
165Hypergammaglobulinemia (HP:0010702)1.85644919
166Chest pain (HP:0100749)1.85401794
167IgM deficiency (HP:0002850)1.84674225
168Recurrent lower respiratory tract infections (HP:0002783)1.84232794
169Vacuolated lymphocytes (HP:0001922)1.84200053
170Recurrent pneumonia (HP:0006532)1.84148084
171Epistaxis (HP:0000421)1.84140286
172Opisthotonus (HP:0002179)1.83982871
173Hyperphosphaturia (HP:0003109)1.82976258
174Prolonged bleeding time (HP:0003010)1.82464425
175Abnormality of polysaccharide metabolism (HP:0011012)1.81545744
176Abnormality of glycosaminoglycan metabolism (HP:0004371)1.81545744
177Abnormality of mucopolysaccharide metabolism (HP:0011020)1.81545744
178Abnormality of alkaline phosphatase activity (HP:0004379)1.80814306
179Hyperacusis (HP:0010780)1.79955085
180Pili torti (HP:0003777)1.79318864
181Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.79048374
182Progressive neurologic deterioration (HP:0002344)1.78793802
183Abnormality of T cells (HP:0002843)1.78687306
184Thin bony cortex (HP:0002753)1.78407187
185Cardiovascular calcification (HP:0011915)1.78049499
186Dehydration (HP:0001944)1.77677845
187Cerebral edema (HP:0002181)1.77329493
188Vertebral compression fractures (HP:0002953)1.76901507
189Megaloblastic anemia (HP:0001889)1.76811355
190Woolly hair (HP:0002224)1.76477966
191Plantar hyperkeratosis (HP:0007556)1.75938264
192Mucopolysacchariduria (HP:0008155)1.75457298
193Urinary glycosaminoglycan excretion (HP:0003541)1.75457298
194Focal segmental glomerulosclerosis (HP:0000097)1.75275409
195Recurrent sinusitis (HP:0011108)1.73921216
196Abnormality of nail color (HP:0100643)1.73636385
197Viral hepatitis (HP:0006562)1.73412239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA28.11684861
2BCKDK4.34148142
3MAP4K13.42431185
4ERN13.19549036
5PRPF4B3.00388196
6MAP2K22.97844580
7SMG12.91124578
8MAPK152.83205356
9MST1R2.55135833
10FRK2.35218188
11RIPK42.27471724
12IRAK42.09556631
13RPS6KB22.07011523
14INSRR2.00333831
15PKN21.99229927
16BLK1.92405614
17MAP3K31.75186702
18FLT31.68651488
19TBK11.67582498
20AKT31.63441787
21FGFR41.61747300
22ICK1.60795248
23TYK21.57833814
24MAP3K141.56973587
25ZAP701.55459285
26SIK11.53218793
27MET1.53000947
28MAP3K101.50839038
29WNK41.45588878
30STK38L1.45526357
31MST41.44324041
32FER1.44124022
33PASK1.44115072
34SRPK11.43805660
35MAP3K21.41536417
36MAPKAPK31.41108506
37JAK31.40008735
38BTK1.39929926
39EPHB21.39564197
40WNK31.39545246
41CSK1.34949822
42TRIB31.34462829
43TAOK31.32270800
44MAP3K131.31516447
45MAP3K111.30148691
46IKBKE1.28585190
47PTK61.28302364
48TESK11.22494824
49FES1.21730720
50ERBB41.21367984
51PTK21.20972306
52IRAK31.18522513
53MARK31.18515683
54CSF1R1.13840632
55DYRK1B1.09743547
56PRKG21.09740809
57SIK31.09113164
58PRKCI1.07610520
59SYK1.07079305
60BUB11.03220041
61PIK3CG1.02948065
62MAP2K10.97757964
63LATS10.97396905
64RIPK10.94482754
65DYRK30.93147950
66IKBKB0.91935348
67CDC42BPA0.91524398
68LRRK20.91079133
69TTK0.88659136
70HCK0.88549701
71TNK20.85853688
72TTN0.85683390
73PAK40.84971610
74MAP3K10.82554436
75WEE10.81877947
76KDR0.80473213
77EIF2AK30.80267675
78TESK20.79667735
79LYN0.79187366
80FGR0.78622375
81PINK10.78501132
82JAK10.78358756
83PDPK10.78240565
84NEK10.77410691
85BRAF0.76078195
86MAPK110.75626142
87TLK10.75344227
88LCK0.73846800
89SIK20.72859938
90MAP3K80.71704293
91STK160.68742346
92NME20.68078862
93MATK0.68004663
94PRKD20.67398051
95SCYL20.63140646
96LMTK20.62398617
97STK100.61332099
98ABL20.61246106
99PDK10.60865058
100GRK60.60053338
101RPS6KC10.59976609
102RPS6KL10.59976609
103CDK40.59945698
104MAP2K60.59101521
105RPS6KA20.58620020
106MARK20.57294875
107BRSK20.55364004
108JAK20.54912441
109CAMK2G0.54858304
110ITK0.54022487
111GSK3A0.50676119
112KIT0.48276317
113MYLK0.47867134
114PDK20.46664953
115TAOK10.46654714
116PAK30.46574386
117MAP2K30.44739115
118PIM20.44150277
119PIM10.43395457
120MTOR0.43287214
121CDK70.42125081
122NME10.42050929
123RAF10.41576893
124RPS6KA60.40721815
125MAPK120.40100715
126PRKCQ0.39897461
127MOS0.39617233
128TGFBR20.38803146
129AURKB0.35046045
130ERBB20.34604263
131RET0.34601384
132CDK90.33562016
133PDK30.32525342
134PDK40.32525342
135CDK120.32321233
136PRKAA20.31924081
137NEK90.31610974
138AURKA0.31133391
139CDK60.30637271
140EPHB10.30231811
141IRAK10.28791823
142KSR20.27965091
143CHUK0.27805551
144MAP3K90.27748998
145ARAF0.25598269
146EEF2K0.24637270
147PIK3CA0.24509972
148TAOK20.23109838
149MAPKAPK20.22736405
150RPS6KA10.22043520
151EPHA30.21821887
152IRAK20.21010668
153PRKAA10.20503994
154HIPK20.20419530
155PLK40.20321661

Predicted pathways (KEGG)

RankGene SetZ-score
1Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.44211918
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.05642267
3Maturity onset diabetes of the young_Homo sapiens_hsa049502.88477976
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.57195239
5B cell receptor signaling pathway_Homo sapiens_hsa046622.53985823
6Sulfur metabolism_Homo sapiens_hsa009202.52864186
7Allograft rejection_Homo sapiens_hsa053302.50638937
8Leishmaniasis_Homo sapiens_hsa051402.44140672
9Primary immunodeficiency_Homo sapiens_hsa053402.39199805
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37343635
11Folate biosynthesis_Homo sapiens_hsa007902.32448531
12Tryptophan metabolism_Homo sapiens_hsa003802.31718943
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.29924598
14Autoimmune thyroid disease_Homo sapiens_hsa053202.29531110
15Graft-versus-host disease_Homo sapiens_hsa053322.26978033
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.25977127
17Fatty acid degradation_Homo sapiens_hsa000712.25472669
18Osteoclast differentiation_Homo sapiens_hsa043802.25105000
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.24082522
20Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.22958509
21Nitrogen metabolism_Homo sapiens_hsa009102.22079793
22Arginine biosynthesis_Homo sapiens_hsa002202.18934147
23Histidine metabolism_Homo sapiens_hsa003402.11831286
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.08964829
25Acute myeloid leukemia_Homo sapiens_hsa052212.07699310
26Selenocompound metabolism_Homo sapiens_hsa004502.04441107
27Fat digestion and absorption_Homo sapiens_hsa049752.01008267
28Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94148110
29Butanoate metabolism_Homo sapiens_hsa006501.92871352
30Drug metabolism - other enzymes_Homo sapiens_hsa009831.91315203
31Chemical carcinogenesis_Homo sapiens_hsa052041.88232768
32Intestinal immune network for IgA production_Homo sapiens_hsa046721.88026145
33Antigen processing and presentation_Homo sapiens_hsa046121.86936166
34Caffeine metabolism_Homo sapiens_hsa002321.83145705
35Peroxisome_Homo sapiens_hsa041461.82977986
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.82753893
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.78142849
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.77960745
39Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.77849452
40Systemic lupus erythematosus_Homo sapiens_hsa053221.74902802
41Viral myocarditis_Homo sapiens_hsa054161.74785357
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.72462565
43beta-Alanine metabolism_Homo sapiens_hsa004101.66790375
44Propanoate metabolism_Homo sapiens_hsa006401.65519398
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65236872
46Tuberculosis_Homo sapiens_hsa051521.64853820
47Asthma_Homo sapiens_hsa053101.64110356
48Influenza A_Homo sapiens_hsa051641.57783138
49Herpes simplex infection_Homo sapiens_hsa051681.57374458
50Type I diabetes mellitus_Homo sapiens_hsa049401.56367250
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55060069
52Phenylalanine metabolism_Homo sapiens_hsa003601.54490300
53Retinol metabolism_Homo sapiens_hsa008301.54425190
54Toxoplasmosis_Homo sapiens_hsa051451.54153303
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52779268
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.50898972
57Complement and coagulation cascades_Homo sapiens_hsa046101.50120009
58Starch and sucrose metabolism_Homo sapiens_hsa005001.49798513
59Vitamin digestion and absorption_Homo sapiens_hsa049771.49600302
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.48781221
61Steroid hormone biosynthesis_Homo sapiens_hsa001401.48500402
62Measles_Homo sapiens_hsa051621.47266098
63Hematopoietic cell lineage_Homo sapiens_hsa046401.45679761
64Glutathione metabolism_Homo sapiens_hsa004801.41521648
65PPAR signaling pathway_Homo sapiens_hsa033201.40351726
66Fatty acid metabolism_Homo sapiens_hsa012121.38629778
67Sulfur relay system_Homo sapiens_hsa041221.34173754
68T cell receptor signaling pathway_Homo sapiens_hsa046601.34018431
69Pyruvate metabolism_Homo sapiens_hsa006201.33542170
70Chronic myeloid leukemia_Homo sapiens_hsa052201.30088085
71Bile secretion_Homo sapiens_hsa049761.29518409
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.28101713
73Cysteine and methionine metabolism_Homo sapiens_hsa002701.28000954
74Apoptosis_Homo sapiens_hsa042101.27172461
75Carbon metabolism_Homo sapiens_hsa012001.26523838
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25623483
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.24205167
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.24046762
79Hepatitis C_Homo sapiens_hsa051601.23530542
80TNF signaling pathway_Homo sapiens_hsa046681.23222641
81Non-small cell lung cancer_Homo sapiens_hsa052231.22608409
82Biosynthesis of amino acids_Homo sapiens_hsa012301.22422147
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.22017719
84Hepatitis B_Homo sapiens_hsa051611.18466255
85Shigellosis_Homo sapiens_hsa051311.18372163
86Tyrosine metabolism_Homo sapiens_hsa003501.17901964
87Viral carcinogenesis_Homo sapiens_hsa052031.17561965
88Arginine and proline metabolism_Homo sapiens_hsa003301.14864929
89Fructose and mannose metabolism_Homo sapiens_hsa000511.12472302
90Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11650911
91Phagosome_Homo sapiens_hsa041451.10633485
92Malaria_Homo sapiens_hsa051441.09462716
93VEGF signaling pathway_Homo sapiens_hsa043701.08168672
94Galactose metabolism_Homo sapiens_hsa000521.05523095
95Pancreatic cancer_Homo sapiens_hsa052121.04570217
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.04493761
97Leukocyte transendothelial migration_Homo sapiens_hsa046701.03298318
98Epstein-Barr virus infection_Homo sapiens_hsa051691.01492885
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00605044
100Salmonella infection_Homo sapiens_hsa051320.99133752
101Legionellosis_Homo sapiens_hsa051340.99030003
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.97942444
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97804988
104Pentose phosphate pathway_Homo sapiens_hsa000300.93285874
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92753055
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.92365199
107Rheumatoid arthritis_Homo sapiens_hsa053230.92334117
108ABC transporters_Homo sapiens_hsa020100.92039548
109Central carbon metabolism in cancer_Homo sapiens_hsa052300.90560156
110HTLV-I infection_Homo sapiens_hsa051660.90336315
111Chemokine signaling pathway_Homo sapiens_hsa040620.88934229
112Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.87953637
113NOD-like receptor signaling pathway_Homo sapiens_hsa046210.87679389
114Pertussis_Homo sapiens_hsa051330.87226049
115One carbon pool by folate_Homo sapiens_hsa006700.87150440
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83687665
117Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83117840
118Notch signaling pathway_Homo sapiens_hsa043300.79774814
119Fatty acid elongation_Homo sapiens_hsa000620.78695197
120Glycerolipid metabolism_Homo sapiens_hsa005610.78230685
121Protein export_Homo sapiens_hsa030600.75355970
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75293354
123Endometrial cancer_Homo sapiens_hsa052130.73849476
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.72854805
125Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71957443
126Renal cell carcinoma_Homo sapiens_hsa052110.69366625
127Linoleic acid metabolism_Homo sapiens_hsa005910.68346515
128Steroid biosynthesis_Homo sapiens_hsa001000.68019743
129Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67854001
130Endocytosis_Homo sapiens_hsa041440.67802898
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67379150
132Mineral absorption_Homo sapiens_hsa049780.66572404
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.66325315
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65191735
135Renin-angiotensin system_Homo sapiens_hsa046140.65111752
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.63283397
137Metabolic pathways_Homo sapiens_hsa011000.62874968
138Alcoholism_Homo sapiens_hsa050340.61583079
139African trypanosomiasis_Homo sapiens_hsa051430.57877962
140Prolactin signaling pathway_Homo sapiens_hsa049170.56234115
141Lysine degradation_Homo sapiens_hsa003100.55739867
142Platelet activation_Homo sapiens_hsa046110.55417254
143Adipocytokine signaling pathway_Homo sapiens_hsa049200.54491037
144Amoebiasis_Homo sapiens_hsa051460.54399189
145Small cell lung cancer_Homo sapiens_hsa052220.54091929
146HIF-1 signaling pathway_Homo sapiens_hsa040660.53277275
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52858407
148Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51559267
149Insulin signaling pathway_Homo sapiens_hsa049100.49938526
150Staphylococcus aureus infection_Homo sapiens_hsa051500.49159867
151Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47495777
152Arachidonic acid metabolism_Homo sapiens_hsa005900.46946300
153Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44709461
154Vitamin B6 metabolism_Homo sapiens_hsa007500.43672177
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43260117
156mTOR signaling pathway_Homo sapiens_hsa041500.42829697
157Other glycan degradation_Homo sapiens_hsa005110.41863642
158Glycerophospholipid metabolism_Homo sapiens_hsa005640.40976284
159Protein digestion and absorption_Homo sapiens_hsa049740.39691553
160ErbB signaling pathway_Homo sapiens_hsa040120.38672629
161Inositol phosphate metabolism_Homo sapiens_hsa005620.35444971
162Colorectal cancer_Homo sapiens_hsa052100.34946664
163Bladder cancer_Homo sapiens_hsa052190.33640807
164Base excision repair_Homo sapiens_hsa034100.33486076
165Proteasome_Homo sapiens_hsa030500.33425860
166Phosphatidylinositol signaling system_Homo sapiens_hsa040700.31834010
167N-Glycan biosynthesis_Homo sapiens_hsa005100.27564629
168Regulation of autophagy_Homo sapiens_hsa041400.23202610
169Lysosome_Homo sapiens_hsa041420.22029982
170Prion diseases_Homo sapiens_hsa050200.19761478
171Glycosaminoglycan degradation_Homo sapiens_hsa005310.18825153
172Insulin resistance_Homo sapiens_hsa049310.17678327
173Tight junction_Homo sapiens_hsa045300.12399070
174Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12387460
175Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.11102297
176Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.09064285
177Thyroid hormone synthesis_Homo sapiens_hsa049180.08615260
178Thyroid cancer_Homo sapiens_hsa052160.06752152
179Pyrimidine metabolism_Homo sapiens_hsa002400.05158066
180Sphingolipid metabolism_Homo sapiens_hsa006000.04826640
181Glucagon signaling pathway_Homo sapiens_hsa049220.04754268
182Pancreatic secretion_Homo sapiens_hsa049720.04140117
183Vibrio cholerae infection_Homo sapiens_hsa051100.02778003

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