TMEM104

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.13502698
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.13502698
3modulation by symbiont of host immune response (GO:0052553)6.13502698
4positive regulation by symbiont of host defense response (GO:0052509)6.13502698
5modulation by symbiont of host defense response (GO:0052031)6.13502698
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.13502698
7regulation of interferon-beta biosynthetic process (GO:0045357)6.07480598
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.02230308
9macrophage activation involved in immune response (GO:0002281)4.59553047
10neutrophil activation involved in immune response (GO:0002283)4.46509830
11protein localization to endosome (GO:0036010)4.43953115
12positive regulation of mast cell activation (GO:0033005)4.16877206
13respiratory burst (GO:0045730)4.11580830
14positive regulation of interferon-alpha production (GO:0032727)4.09171013
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.02567087
16protein retention in ER lumen (GO:0006621)3.99125300
17immunoglobulin mediated immune response (GO:0016064)3.97422149
18regulation of B cell receptor signaling pathway (GO:0050855)3.90996027
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90606232
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90606232
21mannose metabolic process (GO:0006013)3.88289885
22response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.87401038
23response to host immune response (GO:0052572)3.87401038
24regulation of interferon-alpha production (GO:0032647)3.85916556
25maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.83893919
26stress fiber assembly (GO:0043149)3.83642642
27skin morphogenesis (GO:0043589)3.81992911
28negative regulation of erythrocyte differentiation (GO:0045647)3.70771539
29positive regulation of receptor recycling (GO:0001921)3.68513237
30apoptotic cell clearance (GO:0043277)3.67352168
31positive regulation of mast cell degranulation (GO:0043306)3.67246946
32positive regulation of mast cell activation involved in immune response (GO:0033008)3.67246946
33microglial cell activation (GO:0001774)3.67031585
34response to host defenses (GO:0052200)3.61163349
35response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.61163349
36response to host (GO:0075136)3.61163349
37regulation of early endosome to late endosome transport (GO:2000641)3.58209317
38basement membrane organization (GO:0071711)3.57665344
39protein maturation by protein folding (GO:0022417)3.54953748
40positive regulation of leukocyte degranulation (GO:0043302)3.53412447
41negative regulation of granulocyte differentiation (GO:0030853)3.51165056
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.50371289
43regulation of mast cell degranulation (GO:0043304)3.44087431
44antigen processing and presentation of endogenous antigen (GO:0019883)3.37767822
45cell-substrate junction assembly (GO:0007044)3.34258955
46neutrophil mediated immunity (GO:0002446)3.33510954
47pinocytosis (GO:0006907)3.32993827
48regulation of superoxide anion generation (GO:0032928)3.29985446
49myeloid cell activation involved in immune response (GO:0002275)3.27141004
50pentose-phosphate shunt (GO:0006098)3.27081831
51positive regulation of gamma-delta T cell activation (GO:0046645)3.25873884
52regulation of mast cell activation involved in immune response (GO:0033006)3.21137741
53regulation of cholesterol storage (GO:0010885)3.21122859
54positive regulation of antigen processing and presentation (GO:0002579)3.20673801
55response to peptidoglycan (GO:0032494)3.19078193
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.19025558
57adherens junction assembly (GO:0034333)3.18685649
58regulation of leukocyte degranulation (GO:0043300)3.17943214
59negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.16678260
60regulation of mammary gland epithelial cell proliferation (GO:0033599)3.15128013
61macrophage activation (GO:0042116)3.13870941
62proline biosynthetic process (GO:0006561)3.08958899
63regulation of mast cell activation (GO:0033003)3.07936316
64hyaluronan catabolic process (GO:0030214)3.03423883
65negative regulation of cell killing (GO:0031342)3.02300364
66negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.02300364
67cellular extravasation (GO:0045123)3.00998362
68keratan sulfate catabolic process (GO:0042340)3.00809274
69hemidesmosome assembly (GO:0031581)2.99655259
70positive regulation of B cell differentiation (GO:0045579)2.98570264
71regulation of macrophage chemotaxis (GO:0010758)2.97886253
72Arp2/3 complex-mediated actin nucleation (GO:0034314)2.97096224
73focal adhesion assembly (GO:0048041)2.92835476
74cell-substrate adherens junction assembly (GO:0007045)2.92835476
75production of molecular mediator involved in inflammatory response (GO:0002532)2.92834673
76positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90389535
77response to laminar fluid shear stress (GO:0034616)2.89728721
78L-alpha-amino acid transmembrane transport (GO:1902475)2.89289985
79NADPH regeneration (GO:0006740)2.88845224
80hydrogen peroxide biosynthetic process (GO:0050665)2.88576018
81glucose catabolic process (GO:0006007)2.88337433
82neutrophil activation (GO:0042119)2.87975400
83regulation of myeloid leukocyte mediated immunity (GO:0002886)2.85011838
84positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.84786648
85reactive oxygen species biosynthetic process (GO:1903409)2.82601536
86granulocyte activation (GO:0036230)2.82071990
87glucose 6-phosphate metabolic process (GO:0051156)2.80893211
88semaphorin-plexin signaling pathway (GO:0071526)2.80509627
89positive regulation of blood vessel endothelial cell migration (GO:0043536)2.79998359
90negative regulation of cell size (GO:0045792)2.79338999
91positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.79202327
92positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.78100486
93apoptotic process involved in morphogenesis (GO:0060561)2.77892392
94glycolipid catabolic process (GO:0019377)2.73173897
95positive regulation of interferon-beta production (GO:0032728)2.72630363
96B cell mediated immunity (GO:0019724)2.70005330
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.69791637
98low-density lipoprotein particle clearance (GO:0034383)2.69300464
99regulation of extracellular matrix disassembly (GO:0010715)2.69206704
100negative regulation of interleukin-6 production (GO:0032715)2.68516809
101platelet aggregation (GO:0070527)2.68153335
102actin nucleation (GO:0045010)2.67811859
103regulation of antigen processing and presentation (GO:0002577)2.67771767
104I-kappaB phosphorylation (GO:0007252)2.67601286
105negative regulation of stress fiber assembly (GO:0051497)2.65556198
106negative regulation of homotypic cell-cell adhesion (GO:0034111)2.63920466
107regulation of regulated secretory pathway (GO:1903305)2.63006872
108response to muramyl dipeptide (GO:0032495)2.62458890
109activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61616703
110regulation of interleukin-8 biosynthetic process (GO:0045414)2.61189352
111epithelial cell-cell adhesion (GO:0090136)2.60386051
112UV protection (GO:0009650)2.59172546
113membrane protein ectodomain proteolysis (GO:0006509)2.58427968
114regulation of phagocytosis (GO:0050764)2.58041108
115positive regulation of Cdc42 GTPase activity (GO:0043089)2.58023534
116positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.57755191
117endodermal cell differentiation (GO:0035987)2.57566960
118cortical actin cytoskeleton organization (GO:0030866)2.56766074
119cellular response to thyroid hormone stimulus (GO:0097067)2.56426703
120modulation by symbiont of host cellular process (GO:0044068)2.55227913
121regulation of mononuclear cell migration (GO:0071675)2.53636410
122positive regulation of phagocytosis (GO:0050766)2.52631281
123barbed-end actin filament capping (GO:0051016)2.51911822
124platelet degranulation (GO:0002576)2.50705007
125hypotonic response (GO:0006971)2.49925807
126negative regulation of phagocytosis (GO:0050765)2.49721279
127B cell receptor signaling pathway (GO:0050853)2.49606340
128fibril organization (GO:0097435)2.48287072
129positive regulation of nuclease activity (GO:0032075)2.46847530
1303-UTR-mediated mRNA stabilization (GO:0070935)2.46105153
131modulation by virus of host process (GO:0019054)2.45726726
132positive regulation of protein dephosphorylation (GO:0035307)2.45724060
133positive regulation of extracellular matrix organization (GO:1903055)2.45249921
134positive regulation of regulated secretory pathway (GO:1903307)2.45079187
135negative regulation of bone resorption (GO:0045779)2.44874415
136membrane raft organization (GO:0031579)2.44432199
137extracellular fibril organization (GO:0043206)2.44165845
138negative regulation of smooth muscle cell migration (GO:0014912)2.43998089
139cell adhesion mediated by integrin (GO:0033627)2.43691517
140response to fungus (GO:0009620)2.43689494
141lipopolysaccharide-mediated signaling pathway (GO:0031663)2.43626318
142myeloid leukocyte mediated immunity (GO:0002444)2.43623278
143COPI coating of Golgi vesicle (GO:0048205)2.43381224
144Golgi transport vesicle coating (GO:0048200)2.43381224
145regulation of B cell differentiation (GO:0045577)2.42956166
146amyloid precursor protein catabolic process (GO:0042987)2.42844436
147leukocyte aggregation (GO:0070486)2.41469709
148response to lipoprotein particle (GO:0055094)2.40047436
149neutrophil chemotaxis (GO:0030593)2.39912474
150regulation of integrin activation (GO:0033623)2.39591930
151planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38875299
152angiogenesis involved in wound healing (GO:0060055)2.38315196
153phagocytosis (GO:0006909)2.37832021
154negative regulation of protein localization to plasma membrane (GO:1903077)2.37068570
155amino sugar catabolic process (GO:0046348)2.36994970
156actin filament polymerization (GO:0030041)2.36440957
157negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.35150024
158glycosphingolipid catabolic process (GO:0046479)2.34223296
159response to thyroid hormone (GO:0097066)2.34206226
160negative regulation of viral release from host cell (GO:1902187)2.33972115
161endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.31805538
162dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31108212
163ceramide catabolic process (GO:0046514)2.30665257
164substrate-dependent cell migration (GO:0006929)2.29656040
165intracellular estrogen receptor signaling pathway (GO:0030520)2.29103463
166endoplasmic reticulum unfolded protein response (GO:0030968)2.28325721
167modulation by virus of host morphology or physiology (GO:0019048)2.27382462
168chondroitin sulfate biosynthetic process (GO:0030206)2.26040402
169positive regulation of endothelial cell apoptotic process (GO:2000353)2.25405650
170cortical cytoskeleton organization (GO:0030865)2.25035176
171vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.24970914
172regulation of receptor recycling (GO:0001919)2.23347201
173negative regulation of fatty acid transport (GO:2000192)2.22525246
174regulation of defense response to virus by virus (GO:0050690)2.21577461
175cellular copper ion homeostasis (GO:0006878)2.20834898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse4.38046198
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.93932487
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.82187785
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.50179106
5* IRF8_27001747_Chip-Seq_BMDM_Mouse3.45776964
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.19756227
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.15419341
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.13741782
9* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10647893
10* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.96028975
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.92243970
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.84430862
13NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.75954214
14STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.75451051
15VDR_21846776_ChIP-Seq_THP-1_Human2.43004508
16SPI1_23127762_ChIP-Seq_K562_Human2.35217048
17* BRD4_27068464_Chip-Seq_AML-cells_Mouse2.33349769
18SCL_19346495_ChIP-Seq_HPC-7_Human2.24756868
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.18222701
20MYC_22102868_ChIP-Seq_BL_Human2.16886177
21RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.10746802
22* VDR_24763502_ChIP-Seq_THP-1_Human2.05531370
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.93681924
24EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87729740
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.86552924
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.86538655
27SPI1_23547873_ChIP-Seq_NB4_Human1.82906648
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80972802
29RUNX_20019798_ChIP-Seq_JUKART_Human1.79656805
30* ELK3_25401928_ChIP-Seq_HUVEC_Human1.79362985
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79001222
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.78647887
33TCF7_22412390_ChIP-Seq_EML_Mouse1.78509120
34IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76715559
35PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.76613438
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.76549487
37MAF_26560356_Chip-Seq_TH1_Human1.76288898
38SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.75593464
39RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.74645443
40LXR_22292898_ChIP-Seq_THP-1_Human1.71757451
41STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67307407
42FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.65757881
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64788555
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64077482
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.64062134
46RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61419707
47KDM2B_26808549_Chip-Seq_DND41_Human1.60358452
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.60327320
49RXR_22158963_ChIP-Seq_LIVER_Mouse1.57461501
50PPARA_22158963_ChIP-Seq_LIVER_Mouse1.57081331
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.56884513
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55949294
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.55426203
54STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54628294
55PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54297974
56MYB_26560356_Chip-Seq_TH2_Human1.54235384
57ZNF263_19887448_ChIP-Seq_K562_Human1.51447363
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.50314481
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48822393
60KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48399854
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46316422
62* GATA1_19941827_ChIP-Seq_MEL_Mouse1.45237018
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44954132
64* PU_27001747_Chip-Seq_BMDM_Mouse1.44370776
65FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.43786164
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43649931
67GATA1_19941826_ChIP-Seq_K562_Human1.43415100
68CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.43232897
69UTX_26944678_Chip-Seq_JUKART_Human1.41728266
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41644703
71GATA1_22025678_ChIP-Seq_K562_Human1.41508900
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41385536
73VDR_24787735_ChIP-Seq_THP-1_Human1.41017046
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39305410
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38093596
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.37478139
77KDM2B_26808549_Chip-Seq_K562_Human1.36785216
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36168009
79LXR_22158963_ChIP-Seq_LIVER_Mouse1.34308546
80ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34184618
81CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32104822
82ESR2_21235772_ChIP-Seq_MCF-7_Human1.31859299
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31618717
84LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31437538
85CLOCK_20551151_ChIP-Seq_293T_Human1.31334635
86SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.29942548
87TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29716138
88KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.28949451
89* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.27980484
90TP53_22127205_ChIP-Seq_IMR90_Human1.24786177
91GATA3_27048872_Chip-Seq_THYMUS_Human1.24568005
92NCOR1_26117541_ChIP-Seq_K562_Human1.24254844
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23668256
94ATF3_27146783_Chip-Seq_COLON_Human1.23645884
95* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.23012285
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23012018
97GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.22710428
98P68_20966046_ChIP-Seq_HELA_Human1.22049140
99* MYB_26560356_Chip-Seq_TH1_Human1.21356339
100TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.20679538
101CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19922027
102WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19663147
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19321283
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.18196154
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17998688
106SA1_27219007_Chip-Seq_ERYTHROID_Human1.17945236
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17931362
108RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17559883
109PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.16335527
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.16268818
111* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14924500
112CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14764306
113TFEB_21752829_ChIP-Seq_HELA_Human1.14269892
114E2F7_22180533_ChIP-Seq_HELA_Human1.13735358
115CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13733082
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.12691159
117FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.11036655
118ELF1_20517297_ChIP-Seq_JURKAT_Human1.09767412
119STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09499544
120UBF1/2_26484160_Chip-Seq_HMECs_Human1.09319926
121GATA2_19941826_ChIP-Seq_K562_Human1.08788364
122RACK7_27058665_Chip-Seq_MCF-7_Human1.08614654
123LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.06775085
124GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06682416
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06173144
126STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06020840
127HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.04017602
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03231831
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03159081
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02437820
131POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01822535
132MAF_26560356_Chip-Seq_TH2_Human1.01511310
133NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01404267
134P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00232742
135SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.00083500
136SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99536713
137TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99185018
138CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99176188
139SMC4_20622854_ChIP-Seq_HELA_Human0.99024604
140FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.98984417
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.98675517
142SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97124197
143ERG_21242973_ChIP-ChIP_JURKAT_Human0.97014904
144PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96830626
145SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92255546
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.90575368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.89583813
2MP0003172_abnormal_lysosome_physiology3.57139154
3MP0009840_abnormal_foam_cell3.48714160
4MP0003303_peritoneal_inflammation3.36588363
5MP0003436_decreased_susceptibility_to2.98209055
6MP0001835_abnormal_antigen_presentation2.73765211
7MP0003191_abnormal_cellular_cholesterol2.70642884
8MP0002419_abnormal_innate_immunity2.69324044
9MP0006082_CNS_inflammation2.59027906
10MP0008260_abnormal_autophagy2.58823986
11MP0003300_gastrointestinal_ulcer2.58336551
12MP0005451_abnormal_body_composition2.41913720
13MP0004272_abnormal_basement_membrane2.41179681
14MP0005464_abnormal_platelet_physiology2.19638162
15MP0003183_abnormal_peptide_metabolism2.19113076
16MP0001849_ear_inflammation2.14755574
17MP0004510_myositis2.13130152
18MP0005000_abnormal_immune_tolerance2.09773157
19MP0005387_immune_system_phenotype2.04581593
20MP0001790_abnormal_immune_system2.04581593
21MP0000604_amyloidosis2.02092932
22MP0001533_abnormal_skeleton_physiology1.99790386
23MP0005025_abnormal_response_to1.99472338
24MP0002452_abnormal_antigen_presenting1.98315441
25MP0000685_abnormal_immune_system1.96500271
26MP0002148_abnormal_hypersensitivity_rea1.89015863
27MP0003690_abnormal_glial_cell1.86978268
28MP0001800_abnormal_humoral_immune1.79591546
29MP0002723_abnormal_immune_serum1.78024886
30MP0000343_altered_response_to1.72343415
31MP0002420_abnormal_adaptive_immunity1.70452522
32MP0001819_abnormal_immune_cell1.70257490
33MP0003075_altered_response_to1.69287002
34MP0003566_abnormal_cell_adhesion1.66993494
35MP0009278_abnormal_bone_marrow1.66096341
36MP0004233_abnormal_muscle_weight1.62787772
37MP0008438_abnormal_cutaneous_collagen1.62659206
38MP0005671_abnormal_response_to1.62574387
39MP0003705_abnormal_hypodermis_morpholog1.60620777
40MP0002405_respiratory_system_inflammati1.58492538
41MP0005670_abnormal_white_adipose1.55481305
42MP0001845_abnormal_inflammatory_respons1.53984074
43MP0002998_abnormal_bone_remodeling1.53053759
44MP0009785_altered_susceptibility_to1.51281071
45MP0003279_aneurysm1.49992177
46MP0003724_increased_susceptibility_to1.49771917
47MP0001853_heart_inflammation1.46117274
48MP0010368_abnormal_lymphatic_system1.42270592
49MP0005257_abnormal_intraocular_pressure1.41838649
50MP0004947_skin_inflammation1.40193843
51MP0000569_abnormal_digit_pigmentation1.38970879
52MP0003448_altered_tumor_morphology1.38356361
53MP0008469_abnormal_protein_level1.37075813
54MP0002933_joint_inflammation1.35537798
55MP0003656_abnormal_erythrocyte_physiolo1.35222065
56MP0002060_abnormal_skin_morphology1.34787378
57MP0000858_altered_metastatic_potential1.34737960
58MP0000465_gastrointestinal_hemorrhage1.34323161
59MP0001851_eye_inflammation1.34035524
60MP0003453_abnormal_keratinocyte_physiol1.33099954
61MP0005310_abnormal_salivary_gland1.32122493
62MP0005409_darkened_coat_color1.30959100
63MP0009333_abnormal_splenocyte_physiolog1.29148593
64MP0002166_altered_tumor_susceptibility1.28777576
65MP0000716_abnormal_immune_system1.26672960
66MP0000689_abnormal_spleen_morphology1.22875423
67MP0005397_hematopoietic_system_phenotyp1.19343931
68MP0001545_abnormal_hematopoietic_system1.19343931
69MP0010030_abnormal_orbit_morphology1.17862193
70MP0002398_abnormal_bone_marrow1.16182871
71MP0000751_myopathy1.13734873
72MP0005623_abnormal_meninges_morphology1.13685857
73MP0002138_abnormal_hepatobiliary_system1.11768037
74MP0001958_emphysema1.11020720
75MP0005174_abnormal_tail_pigmentation1.08755195
76MP0010307_abnormal_tumor_latency1.08478349
77MP0005166_decreased_susceptibility_to1.07942296
78MP0002429_abnormal_blood_cell1.05972104
79MP0005621_abnormal_cell_physiology1.05357936
80MP0002396_abnormal_hematopoietic_system1.03504796
81MP0005076_abnormal_cell_differentiation1.03460765
82MP0004858_abnormal_nervous_system1.03119083
83MP0005501_abnormal_skin_physiology1.02437278
84MP0005390_skeleton_phenotype1.02298115
85MP0005083_abnormal_biliary_tract1.02217799
86MP0009384_cardiac_valve_regurgitation1.01972125
87MP0008004_abnormal_stomach_pH1.01738040
88MP0002722_abnormal_immune_system1.01065234
89MP0000609_abnormal_liver_physiology0.99986893
90MP0009764_decreased_sensitivity_to0.97832905
91MP0009053_abnormal_anal_canal0.97199681
92MP0004130_abnormal_muscle_cell0.96984684
93MP0005023_abnormal_wound_healing0.96914109
94MP0000678_abnormal_parathyroid_gland0.95174888
95MP0002254_reproductive_system_inflammat0.94106678
96MP0002896_abnormal_bone_mineralization0.92136610
97MP0006054_spinal_hemorrhage0.92032546
98MP0005167_abnormal_blood-brain_barrier0.91948304
99MP0003795_abnormal_bone_structure0.91380858
100MP0000249_abnormal_blood_vessel0.90835965
101MP0010155_abnormal_intestine_physiology0.90705109
102MP0000767_abnormal_smooth_muscle0.90085432
103MP0001542_abnormal_bone_strength0.89881936
104MP0001873_stomach_inflammation0.87055242
105MP0005508_abnormal_skeleton_morphology0.85579712
106MP0002796_impaired_skin_barrier0.85515838
107MP0003828_pulmonary_edema0.85276895
108MP0003091_abnormal_cell_migration0.84958458
109MP0002089_abnormal_postnatal_growth/wei0.84830965
110MP0002928_abnormal_bile_duct0.84325132
111MP0003252_abnormal_bile_duct0.83113701
112MP0000733_abnormal_muscle_development0.81287723
113MP0005165_increased_susceptibility_to0.81235777
114MP0010329_abnormal_lipoprotein_level0.79335115
115MP0001915_intracranial_hemorrhage0.78420782
116MP0004808_abnormal_hematopoietic_stem0.77859949
117MP0003329_amyloid_beta_deposits0.77763630
118MP0005666_abnormal_adipose_tissue0.77577767
119MP0002006_tumorigenesis0.77538901
120MP0010352_gastrointestinal_tract_polyps0.76594114
121MP0009763_increased_sensitivity_to0.76444424
122MP0001730_embryonic_growth_arrest0.75518470
123MP0000015_abnormal_ear_pigmentation0.75368371
124MP0000490_abnormal_crypts_of0.74233294
125MP0005384_cellular_phenotype0.73875789
126MP0004185_abnormal_adipocyte_glucose0.73047461
127MP0000598_abnormal_liver_morphology0.72967249
128MP0005584_abnormal_enzyme/coenzyme_acti0.72053511
129MP0001614_abnormal_blood_vessel0.72001294
130MP0005319_abnormal_enzyme/_coenzyme0.71732270
131MP0005164_abnormal_response_to0.71700839
132MP0002877_abnormal_melanocyte_morpholog0.71495129
133MP0000759_abnormal_skeletal_muscle0.71435842
134MP0001216_abnormal_epidermal_layer0.71350511
135MP0000467_abnormal_esophagus_morphology0.68801830
136MP0009931_abnormal_skin_appearance0.68199281
137MP0002249_abnormal_larynx_morphology0.68117475
138MP0000681_abnormal_thyroid_gland0.67815238
139MP0005375_adipose_tissue_phenotype0.67429704
140MP0002113_abnormal_skeleton_development0.67272406
141MP0006138_congestive_heart_failure0.66937099
142MP0000003_abnormal_adipose_tissue0.63956812
143MP0004883_abnormal_blood_vessel0.63859851
144MP0004264_abnormal_extraembryonic_tissu0.63804546
145MP0001348_abnormal_lacrimal_gland0.62001873

Predicted human phenotypes

RankGene SetZ-score
1Increased cerebral lipofuscin (HP:0011813)6.29034365
2Recurrent abscess formation (HP:0002722)5.47203189
3Dysostosis multiplex (HP:0000943)5.42469629
4Increased neuronal autofluorescent lipopigment (HP:0002074)5.39177164
5Vacuolated lymphocytes (HP:0001922)5.30439198
6Systemic lupus erythematosus (HP:0002725)5.13781538
7Eczematoid dermatitis (HP:0000976)5.07145524
8Recurrent bacterial skin infections (HP:0005406)5.05843386
9Mucopolysacchariduria (HP:0008155)4.73622036
10Urinary glycosaminoglycan excretion (HP:0003541)4.73622036
11Recurrent gram-negative bacterial infections (HP:0005420)4.69375091
12Abnormality of glycolipid metabolism (HP:0010969)4.63405393
13Abnormality of liposaccharide metabolism (HP:0010968)4.63405393
14Abnormality of glycosphingolipid metabolism (HP:0004343)4.63405393
15Premature rupture of membranes (HP:0001788)4.55717447
16Abnormality of polysaccharide metabolism (HP:0011012)4.54423098
17Abnormality of glycosaminoglycan metabolism (HP:0004371)4.54423098
18Abnormality of mucopolysaccharide metabolism (HP:0011020)4.54423098
19Abnormality of macrophages (HP:0004311)4.19523546
20Protrusio acetabuli (HP:0003179)3.98973157
21Axonal loss (HP:0003447)3.72351474
22Glomerulonephritis (HP:0000099)3.46459004
23Disinhibition (HP:0000734)3.45122029
24Asymmetric septal hypertrophy (HP:0001670)3.44765729
25Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.33264686
26Loss of speech (HP:0002371)3.29147782
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.23837567
28Recurrent skin infections (HP:0001581)3.00781903
29Complement deficiency (HP:0004431)2.90223382
30Gingivitis (HP:0000230)2.86398426
31Ankle contracture (HP:0006466)2.83341888
32Cerebral aneurysm (HP:0004944)2.82672188
33Myocardial infarction (HP:0001658)2.78142365
34Ulnar bowing (HP:0003031)2.76757332
35Purpura (HP:0000979)2.76078596
36Hyperacusis (HP:0010780)2.75350217
37Abnormal platelet volume (HP:0011876)2.75178502
38Broad face (HP:0000283)2.73133172
39Spontaneous hematomas (HP:0007420)2.70123407
40Recurrent fungal infections (HP:0002841)2.68045818
41Increased mean platelet volume (HP:0011877)2.67086528
42Chronic obstructive pulmonary disease (HP:0006510)2.65671233
43Obstructive lung disease (HP:0006536)2.65671233
44Abnormality of complement system (HP:0005339)2.61341400
45Mediastinal lymphadenopathy (HP:0100721)2.61325483
46Myositis (HP:0100614)2.61243003
47Thoracic kyphosis (HP:0002942)2.59551093
48Menorrhagia (HP:0000132)2.57853308
49Distal lower limb muscle weakness (HP:0009053)2.56585822
50Achilles tendon contracture (HP:0001771)2.54552279
51Increased connective tissue (HP:0009025)2.53336834
52Blue sclerae (HP:0000592)2.50629926
53Atrophic scars (HP:0001075)2.50334862
54Distal lower limb amyotrophy (HP:0008944)2.47353075
55Abnormality of the Achilles tendon (HP:0005109)2.46434674
56Distal upper limb amyotrophy (HP:0007149)2.45970923
57Upper limb amyotrophy (HP:0009129)2.45970923
58Cellulitis (HP:0100658)2.45658024
59Agnosia (HP:0010524)2.44370297
60Spinal rigidity (HP:0003306)2.43676596
61Retinal atrophy (HP:0001105)2.43460261
62Spondylolisthesis (HP:0003302)2.41742999
63Neuronal loss in central nervous system (HP:0002529)2.40380818
64Fragile skin (HP:0001030)2.39290455
65Short nail (HP:0001799)2.37250248
66Autoimmune thrombocytopenia (HP:0001973)2.36760463
67Hematochezia (HP:0002573)2.36750693
68Elevated erythrocyte sedimentation rate (HP:0003565)2.29639998
69Stomatitis (HP:0010280)2.29135479
70Shallow orbits (HP:0000586)2.29053321
71Mitral stenosis (HP:0001718)2.27525731
72Urticaria (HP:0001025)2.27403433
73J-shaped sella turcica (HP:0002680)2.27343147
74Progressive neurologic deterioration (HP:0002344)2.26768123
75Upper motor neuron abnormality (HP:0002127)2.26262212
76Genu recurvatum (HP:0002816)2.26090658
77Vascular tortuosity (HP:0004948)2.25373699
78Joint stiffness (HP:0001387)2.24075520
79Diminished motivation (HP:0000745)2.23433980
80Neurofibrillary tangles (HP:0002185)2.23237639
81Nephritis (HP:0000123)2.22882114
82Apathy (HP:0000741)2.22850500
83Arterial tortuosity (HP:0005116)2.22757327
84Wormian bones (HP:0002645)2.22084039
85Increased variability in muscle fiber diameter (HP:0003557)2.21543312
86Mutism (HP:0002300)2.21201042
87Pathologic fracture (HP:0002756)2.20790482
88Abnormality of the lumbar spine (HP:0100712)2.20639491
89Ovoid vertebral bodies (HP:0003300)2.18505108
90Recurrent viral infections (HP:0004429)2.17698137
91Interstitial pulmonary disease (HP:0006530)2.17254535
92Cervical subluxation (HP:0003308)2.14918978
93Supranuclear gaze palsy (HP:0000605)2.13711283
94Global brain atrophy (HP:0002283)2.12714211
95Prolonged bleeding time (HP:0003010)2.11898153
96Abnormality of the distal phalanges of the toes (HP:0010182)2.11378349
97Hepatosplenomegaly (HP:0001433)2.09167655
98Vertebral compression fractures (HP:0002953)2.08584803
99Abnormality of skeletal muscle fiber size (HP:0012084)2.08147719
100Dilatation of the ascending aorta (HP:0005111)2.06998342
101Mitral regurgitation (HP:0001653)2.03976305
102Abnormality of the thoracic spine (HP:0100711)2.02905124
103Generalized amyotrophy (HP:0003700)2.02815041
104Orchitis (HP:0100796)2.00221625
105Elbow flexion contracture (HP:0002987)1.99842718
106Progressive visual loss (HP:0000529)1.99084577
107Pustule (HP:0200039)1.98263198
108Periodontitis (HP:0000704)1.94855189
109Cardiomegaly (HP:0001640)1.94380016
110Slow saccadic eye movements (HP:0000514)1.94332100
111Gingival bleeding (HP:0000225)1.93794102
112Impaired platelet aggregation (HP:0003540)1.92949025
113Abnormal platelet function (HP:0011869)1.92949025
114Aortic dissection (HP:0002647)1.91579987
115Hemorrhage of the eye (HP:0011885)1.91260635
116Petechiae (HP:0000967)1.91001559
117Basal ganglia calcification (HP:0002135)1.90754548
118Epistaxis (HP:0000421)1.90218979
119Slender build (HP:0001533)1.88838854
120Inflammation of the large intestine (HP:0002037)1.88580634
121Gastrointestinal inflammation (HP:0004386)1.87539969
122Aneurysm (HP:0002617)1.86829071
123Back pain (HP:0003418)1.85980816
124Bladder diverticulum (HP:0000015)1.85775745
125Osteomyelitis (HP:0002754)1.85672014
126Tetraparesis (HP:0002273)1.84774339
127Difficulty climbing stairs (HP:0003551)1.82776592
128Joint laxity (HP:0001388)1.82506003
129Abnormality of the acetabulum (HP:0003170)1.82457459
130Biconcave vertebral bodies (HP:0004586)1.82107135
131Abnormal ossification of hand bones (HP:0005921)1.81466176
132Disproportionate tall stature (HP:0001519)1.81354491
133Peripheral demyelination (HP:0011096)1.81260510
134Abnormality of dentin (HP:0010299)1.80663184
135Amyloidosis (HP:0011034)1.79894479
136Chronic otitis media (HP:0000389)1.79469851
137Long palpebral fissure (HP:0000637)1.79055505
138Flat acetabular roof (HP:0003180)1.78905410
139Abnormality of the nasal mucosa (HP:0000433)1.78782357
140Increased CSF protein (HP:0002922)1.78389256
141Personality changes (HP:0000751)1.78000751
142Cerebral inclusion bodies (HP:0100314)1.77678799
143Aortic aneurysm (HP:0004942)1.77039066
144Deep venous thrombosis (HP:0002625)1.76796451
145Deformed sella turcica (HP:0002681)1.76718133
146Hand muscle atrophy (HP:0009130)1.75193477
147Abnormality of the vasculature of the conjunctiva (HP:0008054)1.73903316
148Mitral valve prolapse (HP:0001634)1.73521893
149Obstructive sleep apnea (HP:0002870)1.72460747
150Natal tooth (HP:0000695)1.72193476
151Nasal polyposis (HP:0100582)1.72145378
152Nonimmune hydrops fetalis (HP:0001790)1.71684773
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.71511760
154Osteolytic defects of the hand bones (HP:0009699)1.71511760
155Hypertriglyceridemia (HP:0002155)1.71026176
156Peritonitis (HP:0002586)1.70213693
157Striae distensae (HP:0001065)1.70155930
158Polygenic inheritance (HP:0010982)1.67936613
159Bone pain (HP:0002653)1.66609621
160Lower limb amyotrophy (HP:0007210)1.66391106
161Abnormality of carpal bone ossification (HP:0006257)1.65518832

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.44200830
2TRIB33.80315737
3PRPF4B3.14735037
4ICK3.14406549
5TGFBR23.01394547
6SMG12.75012050
7MAP4K12.61400512
8TBK12.52785839
9KIT2.50236712
10PKN22.33017180
11TYK22.29367018
12TAOK32.28012992
13BLK2.26822068
14CAMK1D2.14666470
15TESK12.14445214
16ZAP702.08245328
17EPHB11.97711636
18IRAK31.87404047
19TAOK21.82024768
20RIPK41.65379611
21CAMK1G1.63495870
22CSF1R1.59512739
23JAK31.54977923
24TTN1.54802146
25PRKD21.54235605
26SCYL21.51641744
27JAK11.50365804
28STK101.49682115
29EPHA21.40113256
30FES1.37367598
31IRAK41.33748260
32EEF2K1.31666790
33MAP2K31.30662666
34HCK1.30616761
35ARAF1.26968568
36SIK31.26910184
37SIK11.26909679
38PTK61.24560810
39RIPK11.23960450
40CDC42BPA1.21826828
41IKBKE1.21758110
42PIM21.20298020
43NEK91.18984718
44CSK1.16800345
45KDR1.16549089
46JAK21.15701571
47BTK1.15560519
48MAP3K141.14499293
49CAMKK21.08454191
50SYK1.08390878
51PAK41.03320809
52GRK61.03225029
53LRRK21.01504074
54LIMK11.01121681
55CDK121.00218836
56MAP3K131.00139355
57NTRK10.99113165
58TXK0.98573951
59MAP3K110.97856703
60IKBKB0.93531252
61MARK20.93209159
62TRPM70.90263054
63MATK0.89968308
64CAMKK10.89210726
65MAP3K10.85695052
66NME20.85576494
67LCK0.85500157
68EPHB20.84563914
69MARK30.84314991
70ITK0.83908142
71MST1R0.83064573
72LYN0.82409993
73PRKD30.80297954
74RPS6KA40.80105477
75EPHA30.77814864
76DDR20.77554829
77BMX0.76713919
78GRK70.75962921
79PRKCH0.75591874
80FLT30.75571167
81TESK20.74278043
82MAP3K60.74110450
83CDK70.73167522
84DMPK0.73024922
85MAP3K100.70703175
86TAOK10.70609601
87RPS6KA20.69579191
88SIK20.69225220
89EGFR0.69091029
90RPS6KA60.61876712
91FGR0.61447730
92KSR20.61398742
93TEC0.61044003
94FGFR40.60978204
95MAP3K30.58809785
96MYLK0.58288217
97PRKG20.57479467
98STK380.56647580
99CLK10.55868810
100MAP3K80.54836317
101RPS6KC10.54182174
102RPS6KL10.54182174
103MAPK120.54150426
104DYRK1B0.54032625
105MOS0.53932756
106PAK10.53853030
107LATS20.53687423
108ILK0.53135088
109BCKDK0.52990741
110PTK2B0.52976116
111IRAK20.52038426
112MAPK110.51988512
113PDPK10.51954403
114CDK40.51948662
115MAPK150.51906673
116MAP2K20.51087494
117CHUK0.51033291
118BRAF0.50170649
119LMTK20.50150482
120PTK20.49564891
121PIM10.48205711
122PRKCD0.47827017
123CDK60.47698514
124PDGFRA0.47680436
125PDGFRB0.47566528
126PAK20.47555319
127HIPK20.46897535
128PRKD10.46220553
129MAPKAPK20.46038769
130RET0.45655923
131MTOR0.44861447
132ABL20.44768040
133MAPK70.44044766
134CDK90.41711974

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.35884618
2Lysosome_Homo sapiens_hsa041423.83564669
3Staphylococcus aureus infection_Homo sapiens_hsa051503.63834121
4Other glycan degradation_Homo sapiens_hsa005113.53577383
5Osteoclast differentiation_Homo sapiens_hsa043802.54216575
6Leishmaniasis_Homo sapiens_hsa051402.47742876
7Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17450865
8Tuberculosis_Homo sapiens_hsa051521.93993107
9Bladder cancer_Homo sapiens_hsa052191.91409417
10Toll-like receptor signaling pathway_Homo sapiens_hsa046201.84315121
11Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80752617
12B cell receptor signaling pathway_Homo sapiens_hsa046621.79384486
13Pertussis_Homo sapiens_hsa051331.75417637
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.68000842
15Complement and coagulation cascades_Homo sapiens_hsa046101.62973213
16Phagosome_Homo sapiens_hsa041451.61266641
17Caffeine metabolism_Homo sapiens_hsa002321.55822378
18Central carbon metabolism in cancer_Homo sapiens_hsa052301.48107884
19Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46290290
20ECM-receptor interaction_Homo sapiens_hsa045121.41816926
21Malaria_Homo sapiens_hsa051441.34631393
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33762446
23Antigen processing and presentation_Homo sapiens_hsa046121.33151828
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.32689781
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27316082
26Legionellosis_Homo sapiens_hsa051341.25972699
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25106072
28Toxoplasmosis_Homo sapiens_hsa051451.23959441
29Endometrial cancer_Homo sapiens_hsa052131.20923390
30Chronic myeloid leukemia_Homo sapiens_hsa052201.20778827
31Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.20668396
32Small cell lung cancer_Homo sapiens_hsa052221.19555702
33Shigellosis_Homo sapiens_hsa051311.18950780
34Apoptosis_Homo sapiens_hsa042101.18473127
35Thyroid cancer_Homo sapiens_hsa052161.17634743
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14401684
37Nitrogen metabolism_Homo sapiens_hsa009101.13364903
38Salmonella infection_Homo sapiens_hsa051321.13012280
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.06960644
40Measles_Homo sapiens_hsa051621.06529346
41Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02407711
42Acute myeloid leukemia_Homo sapiens_hsa052211.00549453
43Prostate cancer_Homo sapiens_hsa052150.98924662
44Fructose and mannose metabolism_Homo sapiens_hsa000510.98865697
45Renin-angiotensin system_Homo sapiens_hsa046140.98361730
46NF-kappa B signaling pathway_Homo sapiens_hsa040640.97545589
47Chemokine signaling pathway_Homo sapiens_hsa040620.97351562
48Adherens junction_Homo sapiens_hsa045200.96377120
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.95228745
50Pancreatic cancer_Homo sapiens_hsa052120.94785616
51Influenza A_Homo sapiens_hsa051640.93890035
52Prion diseases_Homo sapiens_hsa050200.92701781
53Amoebiasis_Homo sapiens_hsa051460.92076848
54Sulfur relay system_Homo sapiens_hsa041220.91485927
55Rheumatoid arthritis_Homo sapiens_hsa053230.91016155
56Platelet activation_Homo sapiens_hsa046110.90252453
57Hepatitis B_Homo sapiens_hsa051610.89800540
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89588821
59Hematopoietic cell lineage_Homo sapiens_hsa046400.89159620
60Endocytosis_Homo sapiens_hsa041440.87053496
61Jak-STAT signaling pathway_Homo sapiens_hsa046300.86005214
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84466371
63TNF signaling pathway_Homo sapiens_hsa046680.84005556
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.80343434
65Asthma_Homo sapiens_hsa053100.77935007
66Sphingolipid signaling pathway_Homo sapiens_hsa040710.77100758
67MicroRNAs in cancer_Homo sapiens_hsa052060.76414636
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.76369953
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76191926
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.75245395
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73500873
72Insulin resistance_Homo sapiens_hsa049310.71542847
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.71455273
74Sphingolipid metabolism_Homo sapiens_hsa006000.70799312
75Biosynthesis of amino acids_Homo sapiens_hsa012300.70602030
76Viral myocarditis_Homo sapiens_hsa054160.70078660
77Galactose metabolism_Homo sapiens_hsa000520.69790016
78Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68364574
79ErbB signaling pathway_Homo sapiens_hsa040120.68048148
80Notch signaling pathway_Homo sapiens_hsa043300.65940910
81Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64674190
82Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64448733
83Viral carcinogenesis_Homo sapiens_hsa052030.63539584
84AMPK signaling pathway_Homo sapiens_hsa041520.59608920
85N-Glycan biosynthesis_Homo sapiens_hsa005100.59555678
86HTLV-I infection_Homo sapiens_hsa051660.58922571
87Pathways in cancer_Homo sapiens_hsa052000.58801656
88Hepatitis C_Homo sapiens_hsa051600.58229079
89GnRH signaling pathway_Homo sapiens_hsa049120.58187616
90Choline metabolism in cancer_Homo sapiens_hsa052310.57131206
91VEGF signaling pathway_Homo sapiens_hsa043700.55939204
92Estrogen signaling pathway_Homo sapiens_hsa049150.55863726
93T cell receptor signaling pathway_Homo sapiens_hsa046600.55577977
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.54527326
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54291644
96Starch and sucrose metabolism_Homo sapiens_hsa005000.54114833
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.53999590
98Inositol phosphate metabolism_Homo sapiens_hsa005620.53327659
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53178503
100Proteoglycans in cancer_Homo sapiens_hsa052050.52141060
101PPAR signaling pathway_Homo sapiens_hsa033200.50156142
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48888487
103ABC transporters_Homo sapiens_hsa020100.48880931
104Renal cell carcinoma_Homo sapiens_hsa052110.48573386
105HIF-1 signaling pathway_Homo sapiens_hsa040660.48486681
106Rap1 signaling pathway_Homo sapiens_hsa040150.48424782
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47794441
108Melanoma_Homo sapiens_hsa052180.47533359
109Pentose phosphate pathway_Homo sapiens_hsa000300.46911836
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.46908213
111NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44889943
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44742658
113Type II diabetes mellitus_Homo sapiens_hsa049300.44673059
114Non-small cell lung cancer_Homo sapiens_hsa052230.44633509
115Focal adhesion_Homo sapiens_hsa045100.44282886
116Herpes simplex infection_Homo sapiens_hsa051680.43087369
117Vibrio cholerae infection_Homo sapiens_hsa051100.42380007
118Lysine degradation_Homo sapiens_hsa003100.41829381
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41329398
120Colorectal cancer_Homo sapiens_hsa052100.40884370
121Fatty acid degradation_Homo sapiens_hsa000710.40416225
122Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40269108
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34993970
124Prolactin signaling pathway_Homo sapiens_hsa049170.34518955
125Arginine biosynthesis_Homo sapiens_hsa002200.34053907
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33696727
127Insulin signaling pathway_Homo sapiens_hsa049100.33059612
128Dorso-ventral axis formation_Homo sapiens_hsa043200.32573734
129Bile secretion_Homo sapiens_hsa049760.32182667
130mTOR signaling pathway_Homo sapiens_hsa041500.31321006
131Glioma_Homo sapiens_hsa052140.28202466

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