ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.30078036
2	L-fucose catabolic process (GO:0042355)	4.72617974
3	fucose catabolic process (GO:0019317)	4.72617974
4	L-fucose metabolic process (GO:0042354)	4.72617974
5	negative regulation of telomere maintenance (GO:0032205)	3.93756699
6	response to pheromone (GO:0019236)	3.85485988
7	protein-cofactor linkage (GO:0018065)	3.83819339
8	DNA deamination (GO:0045006)	3.78643984
9	cellular ketone body metabolic process (GO:0046950)	3.71107969
10	platelet dense granule organization (GO:0060155)	3.64724325
11	indolalkylamine metabolic process (GO:0006586)	3.54366549
12	water-soluble vitamin biosynthetic process (GO:0042364)	3.39268818
13	ketone body metabolic process (GO:1902224)	3.38857418
14	piRNA metabolic process (GO:0034587)	3.38059786
15	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.34372521
16	respiratory chain complex IV assembly (GO:0008535)	3.32343415
17	tryptophan catabolic process (GO:0006569)	3.31327241
18	indole-containing compound catabolic process (GO:0042436)	3.31327241
19	indolalkylamine catabolic process (GO:0046218)	3.31327241
20	replication fork processing (GO:0031297)	3.28639707
21	kynurenine metabolic process (GO:0070189)	3.26027861
22	protein complex biogenesis (GO:0070271)	3.19418292
23	detection of light stimulus involved in sensory perception (GO:0050962)	3.17598836
24	detection of light stimulus involved in visual perception (GO:0050908)	3.17598836
25	DNA double-strand break processing (GO:0000729)	3.17048184
26	epithelial cilium movement (GO:0003351)	3.17008303
27	preassembly of GPI anchor in ER membrane (GO:0016254)	3.16885142
28	mannosylation (GO:0097502)	3.15924453
29	protein polyglutamylation (GO:0018095)	3.14792293
30	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13622332
31	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13622332
32	NADH dehydrogenase complex assembly (GO:0010257)	3.13622332
33	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.11757272
34	axoneme assembly (GO:0035082)	3.11455347
35	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.05685174
36	cytochrome complex assembly (GO:0017004)	3.04637860
37	tryptophan metabolic process (GO:0006568)	3.00129691
38	male meiosis (GO:0007140)	2.94690640
39	mitochondrial respiratory chain complex assembly (GO:0033108)	2.92037159
40	protein K11-linked deubiquitination (GO:0035871)	2.90688500
41	regulation of glucokinase activity (GO:0033131)	2.89959527
42	regulation of hexokinase activity (GO:1903299)	2.89959527
43	negative regulation of mast cell activation (GO:0033004)	2.86625629
44	S-adenosylmethionine metabolic process (GO:0046500)	2.85546297
45	neuronal action potential (GO:0019228)	2.81034940
46	cilium morphogenesis (GO:0060271)	2.80993455
47	cornea development in camera-type eye (GO:0061303)	2.77601843
48	neural tube formation (GO:0001841)	2.77594286
49	dopamine transport (GO:0015872)	2.76299142
50	behavioral response to ethanol (GO:0048149)	2.76254350
51	synaptic transmission, cholinergic (GO:0007271)	2.73727424
52	regulation of cilium movement (GO:0003352)	2.72457400
53	ubiquinone biosynthetic process (GO:0006744)	2.72005321
54	retinal cone cell development (GO:0046549)	2.71273620
55	chaperone-mediated protein transport (GO:0072321)	2.69946926
56	reciprocal meiotic recombination (GO:0007131)	2.68031773
57	reciprocal DNA recombination (GO:0035825)	2.68031773
58	regulation of telomere maintenance (GO:0032204)	2.67592081
59	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66130338
60	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.65794831
61	ATP synthesis coupled proton transport (GO:0015986)	2.65794831
62	DNA methylation involved in gamete generation (GO:0043046)	2.64809512
63	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.64747447
64	protein localization to cilium (GO:0061512)	2.64702421
65	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.64337808
66	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.64337808
67	neurofilament cytoskeleton organization (GO:0060052)	2.63802049
68	regulation of action potential (GO:0098900)	2.62773551
69	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	2.62562148
70	photoreceptor cell development (GO:0042461)	2.62052665
71	indole-containing compound metabolic process (GO:0042430)	2.60212898
72	recombinational repair (GO:0000725)	2.59699171
73	peptidyl-histidine modification (GO:0018202)	2.58994065
74	ubiquinone metabolic process (GO:0006743)	2.58165334
75	cellular biogenic amine catabolic process (GO:0042402)	2.57826381
76	amine catabolic process (GO:0009310)	2.57826381
77	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.57464840
78	rRNA catabolic process (GO:0016075)	2.57175665
79	photoreceptor cell maintenance (GO:0045494)	2.57040240
80	double-strand break repair via homologous recombination (GO:0000724)	2.56774317
81	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.56245273
82	kidney morphogenesis (GO:0060993)	2.55801772
83	nonmotile primary cilium assembly (GO:0035058)	2.54553837
84	regulation of neurotransmitter uptake (GO:0051580)	2.54430824
85	auditory receptor cell stereocilium organization (GO:0060088)	2.54201527
86	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.54189778
87	pyrimidine nucleobase catabolic process (GO:0006208)	2.53682825
88	amino acid salvage (GO:0043102)	2.53452580
89	L-methionine salvage (GO:0071267)	2.53452580
90	L-methionine biosynthetic process (GO:0071265)	2.53452580
91	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.52352876
92	gamma-aminobutyric acid transport (GO:0015812)	2.52229318
93	tRNA processing (GO:0008033)	2.51598866
94	rhodopsin mediated signaling pathway (GO:0016056)	2.50529605
95	cilium organization (GO:0044782)	2.49933893
96	adaptation of signaling pathway (GO:0023058)	2.49148193
97	glycerophospholipid catabolic process (GO:0046475)	2.49092574
98	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.48625385
99	anterograde synaptic vesicle transport (GO:0048490)	2.47087997
100	glyoxylate metabolic process (GO:0046487)	2.46720089

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.21538483
2	VDR_22108803_ChIP-Seq_LS180_Human	3.65372633
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.20352603
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.87265398
5	IGF1R_20145208_ChIP-Seq_DFB_Human	2.81415541
6	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.42843224
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.41924618
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.41815881
9	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39115550
10	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29633751
11	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.21946388
12	EZH2_22144423_ChIP-Seq_EOC_Human	2.13811565
13	EWS_26573619_Chip-Seq_HEK293_Human	2.09733776
14	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.04198228
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01673460
16	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.99563113
17	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.97440182
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.97151383
19	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.96600943
20	P300_19829295_ChIP-Seq_ESCs_Human	1.91128910
21	FUS_26573619_Chip-Seq_HEK293_Human	1.91056134
22	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.82858013
23	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.82090806
24	ER_23166858_ChIP-Seq_MCF-7_Human	1.81113969
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.80074232
26	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.78045445
27	TP53_22573176_ChIP-Seq_HFKS_Human	1.76930831
28	IRF1_19129219_ChIP-ChIP_H3396_Human	1.70270750
29	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.65075645
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.58655040
31	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.58610098
32	CBP_20019798_ChIP-Seq_JUKART_Human	1.58610098
33	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.57379370
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53994222
35	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.53294306
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.48144341
37	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.47233916
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45794316
39	VDR_23849224_ChIP-Seq_CD4+_Human	1.43928950
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42165702
41	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.41282445
42	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.40379835
43	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.40379835
44	ELK1_19687146_ChIP-ChIP_HELA_Human	1.36809487
45	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.36380774
46	SOX2_19829295_ChIP-Seq_ESCs_Human	1.35558355
47	NANOG_19829295_ChIP-Seq_ESCs_Human	1.35558355
48	STAT3_23295773_ChIP-Seq_U87_Human	1.35254011
49	AR_25329375_ChIP-Seq_VCAP_Human	1.35118378
50	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.33043686
51	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32435921
52	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.30470265
53	TCF4_22108803_ChIP-Seq_LS180_Human	1.29851291
54	* TCF4_23295773_ChIP-Seq_U87_Human	1.29248027
55	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.28871219
56	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.28493946
57	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.28445085
58	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.27869274
59	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.26086882
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.25670340
61	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.25080826
62	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.23754829
63	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.22343089
64	NCOR_22424771_ChIP-Seq_293T_Human	1.22177751
65	* ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21481517
66	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.20779733
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.19951404
68	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.19951404
69	AR_20517297_ChIP-Seq_VCAP_Human	1.19069271
70	REST_21632747_ChIP-Seq_MESCs_Mouse	1.18244968
71	HOXB7_26014856_ChIP-Seq_BT474_Human	1.17049352
72	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.16816336
73	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15666368
74	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.15276573
75	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.15111271
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.14230379
77	* AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.11343803
78	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.11046767
79	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10255452
80	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.09923185
81	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.09755290
82	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.09753087
83	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.09557992
84	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.09402435
85	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.09217573
86	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.07432841
87	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.05244102
88	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.05197573
89	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.04817733
90	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03727834
91	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.02395939
92	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.00943076
93	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99856911
94	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99329316
95	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.97066880
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.96272508
97	FOXP3_21729870_ChIP-Seq_TREG_Human	0.94912605
98	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.94735244
99	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.94633069
100	CDX2_22108803_ChIP-Seq_LS180_Human	0.92654305

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.34385633
2	MP0003195_calcinosis	2.89027808
3	MP0002102_abnormal_ear_morphology	2.63253563
4	MP0008875_abnormal_xenobiotic_pharmacok	2.51063027
5	MP0005551_abnormal_eye_electrophysiolog	2.46483518
6	MP0003787_abnormal_imprinting	2.38477492
7	MP0002876_abnormal_thyroid_physiology	2.37075459
8	MP0006072_abnormal_retinal_apoptosis	2.32695910
9	MP0001986_abnormal_taste_sensitivity	2.20466165
10	MP0001968_abnormal_touch/_nociception	2.15497670
11	MP0009046_muscle_twitch	2.09086870
12	MP0008872_abnormal_physiological_respon	2.01829039
13	MP0006292_abnormal_olfactory_placode	2.00409623
14	MP0008995_early_reproductive_senescence	2.00104151
15	MP0005645_abnormal_hypothalamus_physiol	1.99314370
16	MP0004885_abnormal_endolymph	1.98680233
17	MP0000372_irregular_coat_pigmentation	1.97228454
18	MP0004142_abnormal_muscle_tone	1.97215177
19	MP0002837_dystrophic_cardiac_calcinosis	1.93149277
20	MP0005253_abnormal_eye_physiology	1.84278391
21	MP0009745_abnormal_behavioral_response	1.82316863
22	MP0002736_abnormal_nociception_after	1.80012548
23	MP0000569_abnormal_digit_pigmentation	1.78630067
24	MP0004147_increased_porphyrin_level	1.77291213
25	MP0003646_muscle_fatigue	1.76390241
26	MP0004043_abnormal_pH_regulation	1.71175159
27	MP0005646_abnormal_pituitary_gland	1.66787920
28	MP0001984_abnormal_olfaction	1.64938984
29	MP0006276_abnormal_autonomic_nervous	1.62118186
30	MP0003880_abnormal_central_pattern	1.56864125
31	MP0000427_abnormal_hair_cycle	1.55569587
32	MP0003011_delayed_dark_adaptation	1.54642158
33	MP0002272_abnormal_nervous_system	1.53920344
34	MP0001529_abnormal_vocalization	1.50518537
35	MP0001501_abnormal_sleep_pattern	1.48275392
36	MP0000631_abnormal_neuroendocrine_gland	1.44625788
37	MP0008058_abnormal_DNA_repair	1.43650790
38	MP0001486_abnormal_startle_reflex	1.43419896
39	MP0002938_white_spotting	1.40223068
40	MP0002638_abnormal_pupillary_reflex	1.39366801
41	MP0004133_heterotaxia	1.38989140
42	MP0005084_abnormal_gallbladder_morpholo	1.35783245
43	MP0001485_abnormal_pinna_reflex	1.35494877
44	MP0005075_abnormal_melanosome_morpholog	1.35480134
45	MP0005174_abnormal_tail_pigmentation	1.35405744
46	MP0004742_abnormal_vestibular_system	1.35347344
47	MP0002234_abnormal_pharynx_morphology	1.32019054
48	MP0002653_abnormal_ependyma_morphology	1.30008087
49	MP0002572_abnormal_emotion/affect_behav	1.25925450
50	MP0003718_maternal_effect	1.24385754
51	MP0003786_premature_aging	1.20934959
52	MP0003121_genomic_imprinting	1.20543932
53	MP0005389_reproductive_system_phenotype	1.18876796
54	MP0003122_maternal_imprinting	1.15202316
55	MP0002557_abnormal_social/conspecific_i	1.14921645
56	MP0001970_abnormal_pain_threshold	1.13922110
57	MP0002928_abnormal_bile_duct	1.13276052
58	MP0001905_abnormal_dopamine_level	1.12592574
59	MP0002064_seizures	1.11659941
60	MP0002160_abnormal_reproductive_system	1.10873321
61	MP0004924_abnormal_behavior	1.10394989
62	MP0005386_behavior/neurological_phenoty	1.10394989
63	MP0002733_abnormal_thermal_nociception	1.08981463
64	MP0002735_abnormal_chemical_nociception	1.07900138
65	MP0001919_abnormal_reproductive_system	1.03521959
66	MP0005085_abnormal_gallbladder_physiolo	1.03448330
67	MP0002067_abnormal_sensory_capabilities	1.00088173
68	MP0003252_abnormal_bile_duct	1.00069563
69	MP0001764_abnormal_homeostasis	0.98621998
70	MP0000383_abnormal_hair_follicle	0.96009938
71	MP0001929_abnormal_gametogenesis	0.93560912
72	MP0003698_abnormal_male_reproductive	0.92398577
73	MP0002751_abnormal_autonomic_nervous	0.91065974
74	MP0005195_abnormal_posterior_eye	0.91039421
75	MP0010386_abnormal_urinary_bladder	0.89790163
76	MP0003136_yellow_coat_color	0.89689536
77	MP0002210_abnormal_sex_determination	0.88872489
78	MP0005332_abnormal_amino_acid	0.88695413
79	MP0004145_abnormal_muscle_electrophysio	0.88023969
80	MP0010329_abnormal_lipoprotein_level	0.87934815
81	MP0008775_abnormal_heart_ventricle	0.87629992
82	MP0002063_abnormal_learning/memory/cond	0.86747991
83	MP0002095_abnormal_skin_pigmentation	0.86110989
84	MP0002163_abnormal_gland_morphology	0.85694443
85	MP0005410_abnormal_fertilization	0.84502965
86	MP0005365_abnormal_bile_salt	0.83491997
87	MP0001324_abnormal_eye_pigmentation	0.83128232
88	MP0005083_abnormal_biliary_tract	0.83030661
89	MP0005379_endocrine/exocrine_gland_phen	0.82015595
90	MP0005171_absent_coat_pigmentation	0.81188893
91	MP0003635_abnormal_synaptic_transmissio	0.80896032
92	MP0000653_abnormal_sex_gland	0.79724216
93	MP0008789_abnormal_olfactory_epithelium	0.78338364
94	MP0000538_abnormal_urinary_bladder	0.77471664
95	MP0002229_neurodegeneration	0.77407267
96	MP0000647_abnormal_sebaceous_gland	0.76281536
97	MP0002752_abnormal_somatic_nervous	0.76183322
98	MP0000778_abnormal_nervous_system	0.75887938
99	MP0002184_abnormal_innervation	0.75865639
100	MP0000230_abnormal_systemic_arterial	0.75188847

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.42704413
2	Abnormality of midbrain morphology (HP:0002418)	4.03223241
3	Molar tooth sign on MRI (HP:0002419)	4.03223241
4	Pancreatic fibrosis (HP:0100732)	3.91584130
5	True hermaphroditism (HP:0010459)	3.71186717
6	Congenital stationary night blindness (HP:0007642)	3.66423724
7	Abnormality of the renal cortex (HP:0011035)	3.45196111
8	Type II lissencephaly (HP:0007260)	3.41963672
9	Nephronophthisis (HP:0000090)	3.38117581
10	Hyperventilation (HP:0002883)	3.30687912
11	Abnormality of the renal medulla (HP:0100957)	2.99028579
12	Medial flaring of the eyebrow (HP:0010747)	2.91766641
13	Attenuation of retinal blood vessels (HP:0007843)	2.86703434
14	Renal cortical cysts (HP:0000803)	2.84766376
15	Abnormal rod and cone electroretinograms (HP:0008323)	2.71594155
16	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.69050974
17	Abnormality of alanine metabolism (HP:0010916)	2.69050974
18	Hyperalaninemia (HP:0003348)	2.69050974
19	Cystic liver disease (HP:0006706)	2.62954491
20	Abolished electroretinogram (ERG) (HP:0000550)	2.62487073
21	Abnormal drinking behavior (HP:0030082)	2.58755067
22	Polydipsia (HP:0001959)	2.58755067
23	Tubular atrophy (HP:0000092)	2.58637964
24	Chronic hepatic failure (HP:0100626)	2.58501365
25	Abnormal biliary tract physiology (HP:0012439)	2.53062653
26	Bile duct proliferation (HP:0001408)	2.53062653
27	Lissencephaly (HP:0001339)	2.48246454
28	Acute necrotizing encephalopathy (HP:0006965)	2.46889262
29	Duplicated collecting system (HP:0000081)	2.46883415
30	Mitochondrial inheritance (HP:0001427)	2.41527798
31	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.39837568
32	Pendular nystagmus (HP:0012043)	2.37710631
33	Increased CSF lactate (HP:0002490)	2.37626365
34	Abnormality of the labia minora (HP:0012880)	2.37622831
35	Abnormality of the renal collecting system (HP:0004742)	2.37197398
36	Inability to walk (HP:0002540)	2.37117917
37	Large for gestational age (HP:0001520)	2.36891436
38	Decreased central vision (HP:0007663)	2.32118907
39	Progressive inability to walk (HP:0002505)	2.25855275
40	Hypothermia (HP:0002045)	2.25339746
41	Acute encephalopathy (HP:0006846)	2.25308704
42	Gait imbalance (HP:0002141)	2.22189779
43	Progressive macrocephaly (HP:0004481)	2.21520466
44	Congenital primary aphakia (HP:0007707)	2.15883712
45	Cerebellar dysplasia (HP:0007033)	2.14503146
46	Hepatic necrosis (HP:0002605)	2.14097101
47	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.14070020
48	Keratoconus (HP:0000563)	2.13250425
49	Increased corneal curvature (HP:0100692)	2.13250425
50	Sclerocornea (HP:0000647)	2.12864121
51	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.11650459
52	3-Methylglutaconic aciduria (HP:0003535)	2.10490455
53	Pachygyria (HP:0001302)	2.10394345
54	Absent thumb (HP:0009777)	2.08580992
55	Ketoacidosis (HP:0001993)	2.06969701
56	Methylmalonic aciduria (HP:0012120)	2.06893894
57	Hepatocellular necrosis (HP:0001404)	2.06744089
58	Polyuria (HP:0000103)	2.06116702
59	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.05800286
60	Retinal dysplasia (HP:0007973)	2.05053788
61	Nephrogenic diabetes insipidus (HP:0009806)	2.04821337
62	Abnormality of the ileum (HP:0001549)	2.04489680
63	Abnormal mitochondria in muscle tissue (HP:0008316)	2.04091333
64	Abnormality of DNA repair (HP:0003254)	2.04071571
65	Stomach cancer (HP:0012126)	2.02943625
66	Lipid accumulation in hepatocytes (HP:0006561)	2.02260738
67	Disproportionate short-trunk short stature (HP:0003521)	2.01504206
68	Ketosis (HP:0001946)	1.99991135
69	Gaze-evoked nystagmus (HP:0000640)	1.98309031
70	Anencephaly (HP:0002323)	1.97068425
71	Optic nerve hypoplasia (HP:0000609)	1.96161869
72	Increased serum lactate (HP:0002151)	1.94243394
73	Meckel diverticulum (HP:0002245)	1.94113280
74	Optic disc pallor (HP:0000543)	1.93813108
75	Congenital hepatic fibrosis (HP:0002612)	1.93104537
76	Severe muscular hypotonia (HP:0006829)	1.92531677
77	Thyroid-stimulating hormone excess (HP:0002925)	1.92134157
78	Methylmalonic acidemia (HP:0002912)	1.91946163
79	Postaxial foot polydactyly (HP:0001830)	1.91817187
80	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.90074532
81	Ectopic kidney (HP:0000086)	1.89378881
82	Broad-based gait (HP:0002136)	1.87668989
83	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.87546496
84	Hypomagnesemia (HP:0002917)	1.83257017
85	Furrowed tongue (HP:0000221)	1.82528597
86	Genital tract atresia (HP:0001827)	1.82148693
87	Progressive microcephaly (HP:0000253)	1.81739377
88	Male pseudohermaphroditism (HP:0000037)	1.81730477
89	Abnormality of the pons (HP:0007361)	1.81383749
90	Hypoplasia of the pons (HP:0012110)	1.81215284
91	Increased hepatocellular lipid droplets (HP:0006565)	1.80823540
92	Decreased circulating renin level (HP:0003351)	1.80589262
93	Intestinal atresia (HP:0011100)	1.79764405
94	Tachypnea (HP:0002789)	1.79362567
95	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.77083755
96	Vaginal atresia (HP:0000148)	1.74801711
97	Thyroiditis (HP:0100646)	1.74148663
98	Febrile seizures (HP:0002373)	1.73464480
99	Chromosomal breakage induced by crosslinking agents (HP:0003221)	1.71689594
100	Lactic acidosis (HP:0003128)	1.71000929

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.75749703
2	TAOK3	4.39959197
3	ADRBK2	3.20294521
4	MAP4K2	3.07014159
5	TXK	2.81104356
6	WNK3	2.79641587
7	BMPR1B	2.59684427
8	PINK1	2.36750651
9	WNK4	2.29530794
10	NUAK1	2.27847999
11	GRK1	2.26824559
12	ZAK	2.16515128
13	INSRR	2.07807021
14	TRIM28	2.04583463
15	BCKDK	1.89900226
16	MAPK13	1.77322673
17	TLK1	1.76339390
18	ACVR1B	1.70018953
19	CASK	1.57561029
20	MAP3K4	1.53006673
21	OXSR1	1.43538560
22	DYRK2	1.29792846
23	STK39	1.25361098
24	TNIK	1.24503090
25	DAPK2	1.22335877
26	MKNK2	1.21964141
27	PAK3	1.18126548
28	ADRBK1	0.99502879
29	MARK1	0.97193708
30	CSNK1G1	0.96281071
31	VRK2	0.96253795
32	CSNK1G3	0.95804496
33	MST4	0.94279324
34	PHKG2	0.93649155
35	PHKG1	0.93649155
36	CSNK1G2	0.93028381
37	PRKCE	0.91945965
38	CAMKK2	0.91318565
39	PLK2	0.90081022
40	PLK4	0.87563963
41	VRK1	0.86776491
42	STK16	0.86340541
43	TGFBR1	0.83152270
44	TIE1	0.82861167
45	MAP4K1	0.82711421
46	ERBB3	0.81163553
47	FGFR2	0.80479937
48	EPHA3	0.80151272
49	MAP2K7	0.79351113
50	PRKCG	0.76465100
51	EIF2AK3	0.74699527
52	CSNK1A1L	0.74369310
53	CCNB1	0.72754176
54	MUSK	0.71867487
55	IKBKB	0.70846047
56	IRAK1	0.70160549
57	NME1	0.68718302
58	BCR	0.68117194
59	MKNK1	0.66087353
60	MAPKAPK5	0.65276650
61	BRSK2	0.64123014
62	PLK3	0.63356518
63	FLT3	0.61374893
64	WEE1	0.60560888
65	TEC	0.60175322
66	MAP2K6	0.59894779
67	PNCK	0.57565627
68	EPHA4	0.54676545
69	PRKCI	0.53666641
70	MAPKAPK3	0.52209812
71	PIK3CA	0.47136553
72	NLK	0.46535581
73	RPS6KA5	0.45663635
74	CSNK1A1	0.45575446
75	AKT3	0.44404621
76	PKN1	0.43630944
77	ATR	0.43209776
78	KIT	0.42410557
79	EIF2AK2	0.41969716
80	PTK2B	0.41911817
81	FER	0.41866710
82	ITK	0.41782473
83	CAMK1	0.41075524
84	PRKCQ	0.41043376
85	STK38L	0.39797056
86	CAMK2A	0.39729840
87	PRKACA	0.39004912
88	LIMK1	0.38961694
89	GRK5	0.37323721
90	NEK2	0.36672128
91	GRK7	0.36199242
92	CSNK1D	0.35741541
93	SRPK1	0.34270370
94	IGF1R	0.33788403
95	CHUK	0.33509764
96	IKBKE	0.32633420
97	PLK1	0.31662632
98	CHEK2	0.31071238
99	TSSK6	0.30528898
100	TNK2	0.29682672

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.59577366
2	Protein export_Homo sapiens_hsa03060	2.52932391
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.52357600
4	Oxidative phosphorylation_Homo sapiens_hsa00190	2.50760082
5	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.46326878
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.45327784
7	Linoleic acid metabolism_Homo sapiens_hsa00591	2.39929065
8	Butanoate metabolism_Homo sapiens_hsa00650	2.33347483
9	Nitrogen metabolism_Homo sapiens_hsa00910	2.24982887
10	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.24704552
11	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.96822111
12	Basal transcription factors_Homo sapiens_hsa03022	1.96681583
13	Propanoate metabolism_Homo sapiens_hsa00640	1.96096844
14	Homologous recombination_Homo sapiens_hsa03440	1.95357344
15	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92515715
16	Parkinsons disease_Homo sapiens_hsa05012	1.92084478
17	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.85463290
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.83742305
19	Selenocompound metabolism_Homo sapiens_hsa00450	1.82247226
20	RNA polymerase_Homo sapiens_hsa03020	1.80241100
21	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.77181972
22	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.75958353
23	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.70489091
24	Tryptophan metabolism_Homo sapiens_hsa00380	1.70197529
25	Caffeine metabolism_Homo sapiens_hsa00232	1.66792694
26	Nicotine addiction_Homo sapiens_hsa05033	1.65074342
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.64857441
28	Proteasome_Homo sapiens_hsa03050	1.40591845
29	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.30596689
30	Peroxisome_Homo sapiens_hsa04146	1.29000867
31	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.26513948
32	RNA degradation_Homo sapiens_hsa03018	1.26163731
33	Sulfur metabolism_Homo sapiens_hsa00920	1.21677219
34	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.20533293
35	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.18533921
36	Asthma_Homo sapiens_hsa05310	1.18375804
37	Huntingtons disease_Homo sapiens_hsa05016	1.16021046
38	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.13358860
39	Taste transduction_Homo sapiens_hsa04742	1.13230847
40	One carbon pool by folate_Homo sapiens_hsa00670	1.12321592
41	Olfactory transduction_Homo sapiens_hsa04740	1.12003971
42	Alzheimers disease_Homo sapiens_hsa05010	1.08819605
43	Chemical carcinogenesis_Homo sapiens_hsa05204	1.08371244
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.03451298
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00819676
46	Cardiac muscle contraction_Homo sapiens_hsa04260	0.99689472
47	Morphine addiction_Homo sapiens_hsa05032	0.98632536
48	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.97282117
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.96685364
50	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.96258353
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.95709721
52	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.92777109
53	Non-homologous end-joining_Homo sapiens_hsa03450	0.90920552
54	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.90781430
55	Retinol metabolism_Homo sapiens_hsa00830	0.89533060
56	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85398429
57	Purine metabolism_Homo sapiens_hsa00230	0.85087672
58	Collecting duct acid secretion_Homo sapiens_hsa04966	0.82040184
59	ABC transporters_Homo sapiens_hsa02010	0.81675002
60	Regulation of autophagy_Homo sapiens_hsa04140	0.80408185
61	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.76979326
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.74311242
63	Insulin secretion_Homo sapiens_hsa04911	0.73163743
64	Metabolic pathways_Homo sapiens_hsa01100	0.73076361
65	Type I diabetes mellitus_Homo sapiens_hsa04940	0.70707058
66	GABAergic synapse_Homo sapiens_hsa04727	0.70226001
67	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.68906257
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.66828272
69	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.66795259
70	Serotonergic synapse_Homo sapiens_hsa04726	0.66347543
71	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.66182061
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.65532802
73	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.65475267
74	Pyrimidine metabolism_Homo sapiens_hsa00240	0.63913769
75	Fat digestion and absorption_Homo sapiens_hsa04975	0.62474755
76	Histidine metabolism_Homo sapiens_hsa00340	0.62021429
77	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.61403996
78	Primary immunodeficiency_Homo sapiens_hsa05340	0.60489660
79	Circadian entrainment_Homo sapiens_hsa04713	0.59551004
80	Glutamatergic synapse_Homo sapiens_hsa04724	0.59046016
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.57189438
82	Nucleotide excision repair_Homo sapiens_hsa03420	0.56548546
83	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55247981
84	Fatty acid elongation_Homo sapiens_hsa00062	0.55026823
85	Mismatch repair_Homo sapiens_hsa03430	0.53565856
86	Sulfur relay system_Homo sapiens_hsa04122	0.52966298
87	Allograft rejection_Homo sapiens_hsa05330	0.52926327
88	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.52726575
89	Fatty acid degradation_Homo sapiens_hsa00071	0.51802513
90	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.50139576
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49319799
92	Salivary secretion_Homo sapiens_hsa04970	0.49182089
93	Fatty acid metabolism_Homo sapiens_hsa01212	0.48671398
94	Mineral absorption_Homo sapiens_hsa04978	0.46104835
95	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.43007734
96	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.42961261
97	RNA transport_Homo sapiens_hsa03013	0.42589064
98	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.42420774
99	Calcium signaling pathway_Homo sapiens_hsa04020	0.37162257
100	Graft-versus-host disease_Homo sapiens_hsa05332	0.35996609

TMEM105

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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