TMEM106A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by symbiont of host defense response (GO:0052031)6.91034710
2modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.91034710
3modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.91034710
4positive regulation by organism of defense response of other organism involved in symbiotic interact6.91034710
5modulation by symbiont of host immune response (GO:0052553)6.91034710
6positive regulation by symbiont of host defense response (GO:0052509)6.91034710
7regulation of interferon-beta biosynthetic process (GO:0045357)5.46217457
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.38634011
9positive regulation of interferon-alpha production (GO:0032727)5.34312214
10neutrophil activation involved in immune response (GO:0002283)5.30994576
11regulation of interferon-alpha production (GO:0032647)5.07090062
12negative regulation of interleukin-12 production (GO:0032695)4.88711868
13macrophage activation involved in immune response (GO:0002281)4.78421157
14response to peptidoglycan (GO:0032494)4.64976412
15immunoglobulin mediated immune response (GO:0016064)4.64168684
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.56875474
17response to host immune response (GO:0052572)4.56875474
18positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.35719124
19regulation of vitamin D biosynthetic process (GO:0060556)4.23502823
20microglial cell activation (GO:0001774)4.19533217
21response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.08102137
22response to host (GO:0075136)4.08102137
23response to host defenses (GO:0052200)4.08102137
24positive regulation of heat generation (GO:0031652)3.89931675
25respiratory burst (GO:0045730)3.89890992
26positive regulation of antigen processing and presentation (GO:0002579)3.86032020
27regulation of mononuclear cell migration (GO:0071675)3.79727076
28regulation of chronic inflammatory response (GO:0002676)3.76434650
29type I interferon signaling pathway (GO:0060337)3.75544544
30cellular response to type I interferon (GO:0071357)3.75544544
31response to type I interferon (GO:0034340)3.71648174
32positive regulation of interferon-beta production (GO:0032728)3.71110194
33granulocyte activation (GO:0036230)3.61121958
34lipopolysaccharide-mediated signaling pathway (GO:0031663)3.58709673
35macrophage activation (GO:0042116)3.56522796
36cellular response to exogenous dsRNA (GO:0071360)3.56127839
37response to protozoan (GO:0001562)3.54864232
38positive regulation of defense response to virus by host (GO:0002230)3.54050835
39myeloid cell activation involved in immune response (GO:0002275)3.50008725
40neutrophil activation (GO:0042119)3.48167198
41response to interferon-alpha (GO:0035455)3.47947384
42regulation of cholesterol storage (GO:0010885)3.47105085
43negative regulation of cytokine production involved in immune response (GO:0002719)3.44737427
44positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.44296441
45regulation of cytokine secretion involved in immune response (GO:0002739)3.40524821
46B cell mediated immunity (GO:0019724)3.38411865
47positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.34394646
48regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34046892
49regulation of fever generation (GO:0031620)3.32845266
50antigen processing and presentation of endogenous antigen (GO:0019883)3.32652145
51regulation of B cell receptor signaling pathway (GO:0050855)3.32003099
52pinocytosis (GO:0006907)3.29056306
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.27810394
54antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.27810394
55regulation of antigen processing and presentation (GO:0002577)3.27620105
56regulation of chemokine biosynthetic process (GO:0045073)3.24873340
57regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.24867648
58natural killer cell mediated immunity (GO:0002228)3.24843296
59natural killer cell mediated cytotoxicity (GO:0042267)3.24843296
60regulation of vitamin metabolic process (GO:0030656)3.24568603
61regulation of interleukin-12 production (GO:0032655)3.23054531
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.23029543
63interferon-gamma-mediated signaling pathway (GO:0060333)3.22122291
64response to muramyl dipeptide (GO:0032495)3.21955142
65regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.18943927
66indole-containing compound catabolic process (GO:0042436)3.17901560
67indolalkylamine catabolic process (GO:0046218)3.17901560
68tryptophan catabolic process (GO:0006569)3.17901560
69positive regulation of mast cell activation (GO:0033005)3.17781863
70regulation of gamma-delta T cell activation (GO:0046643)3.17457633
71regulation of interleukin-8 biosynthetic process (GO:0045414)3.16081647
72detection of molecule of bacterial origin (GO:0032490)3.14568563
73T-helper 1 type immune response (GO:0042088)3.13486851
74production of molecular mediator involved in inflammatory response (GO:0002532)3.13444206
75positive regulation of type 2 immune response (GO:0002830)3.09908023
76hydrogen peroxide biosynthetic process (GO:0050665)3.08242004
77modulation of growth of symbiont involved in interaction with host (GO:0044144)3.07347775
78regulation of growth of symbiont in host (GO:0044126)3.07347775
79negative regulation of growth of symbiont in host (GO:0044130)3.07347775
80negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.07347775
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.06961323
82negative regulation of cell killing (GO:0031342)3.06961323
83positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.05401593
84lymphocyte chemotaxis (GO:0048247)3.04798053
85eosinophil chemotaxis (GO:0048245)3.03040366
86regulation of heat generation (GO:0031650)3.02764427
87low-density lipoprotein particle clearance (GO:0034383)3.02413208
88positive regulation of cellular amide metabolic process (GO:0034250)3.00781277
89positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.99881897
90negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.98522166
91positive regulation of chemokine biosynthetic process (GO:0045080)2.98291031
92negative regulation of nitric oxide biosynthetic process (GO:0045019)2.95856768
93regulation of mast cell degranulation (GO:0043304)2.94922566
94NIK/NF-kappaB signaling (GO:0038061)2.94505479
95regulation of inflammatory response to antigenic stimulus (GO:0002861)2.92810782
96germinal center formation (GO:0002467)2.92624678
97interferon-gamma production (GO:0032609)2.92383948
98regulation of T-helper 1 cell differentiation (GO:0045625)2.92321521
99positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.92176001
100negative regulation of T cell mediated immunity (GO:0002710)2.90652464
101superoxide anion generation (GO:0042554)2.90128908
102I-kappaB phosphorylation (GO:0007252)2.89274709
103myeloid dendritic cell activation (GO:0001773)2.88197392
104negative regulation of interleukin-17 production (GO:0032700)2.87937475
105positive regulation of NF-kappaB import into nucleus (GO:0042346)2.87392247
106positive regulation of mast cell activation involved in immune response (GO:0033008)2.87042867
107positive regulation of mast cell degranulation (GO:0043306)2.87042867
108positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.86528260
109cellular response to interferon-alpha (GO:0035457)2.86146272
110monocyte chemotaxis (GO:0002548)2.85203815
111regulation of T-helper cell differentiation (GO:0045622)2.84759110
112kynurenine metabolic process (GO:0070189)2.84692467
113positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.84490054
114positive regulation of gamma-delta T cell activation (GO:0046645)2.81014251
115regulation of mast cell activation (GO:0033003)2.79853666
116regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79499723
117regulation of interferon-gamma biosynthetic process (GO:0045072)2.78150828
118cellular extravasation (GO:0045123)2.78118472
119myeloid dendritic cell differentiation (GO:0043011)2.77914243
120positive regulation of T-helper cell differentiation (GO:0045624)2.77743504
121regulation of hypersensitivity (GO:0002883)2.77356742
122regulation of mast cell activation involved in immune response (GO:0033006)2.76802767
123positive regulation of leukocyte degranulation (GO:0043302)2.76776217
124cellular response to ethanol (GO:0071361)2.76327562
125regulation of interferon-beta production (GO:0032648)2.76283564
126myeloid leukocyte activation (GO:0002274)2.75831077
127regulation of podosome assembly (GO:0071801)2.75178745
128tryptophan metabolic process (GO:0006568)2.74983184
129dendritic cell differentiation (GO:0097028)2.74176653
130response to interferon-beta (GO:0035456)2.73398365
131defense response to protozoan (GO:0042832)2.73155338
132negative regulation of production of molecular mediator of immune response (GO:0002701)2.72289366
133negative regulation of viral genome replication (GO:0045071)2.72206621
134positive regulation of monocyte chemotaxis (GO:0090026)2.71915302
135cellular response to thyroid hormone stimulus (GO:0097067)2.71212879
136regulation of defense response to virus by host (GO:0050691)2.71212360
137positive regulation of toll-like receptor signaling pathway (GO:0034123)2.71180457
138positive regulation of acute inflammatory response (GO:0002675)2.70415243
139cellular response to virus (GO:0098586)2.68859001
140lymphocyte mediated immunity (GO:0002449)2.67395947
141positive regulation of lymphocyte migration (GO:2000403)2.67244720
142negative regulation of lipid storage (GO:0010888)2.66808607
143positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.65492675
144negative regulation of myeloid cell apoptotic process (GO:0033033)2.64742366
145positive regulation of interleukin-12 production (GO:0032735)2.64385240
146reactive oxygen species biosynthetic process (GO:1903409)2.64170157
147negative regulation of mast cell activation (GO:0033004)2.63888732
148response to thyroid hormone (GO:0097066)2.63565905
149cellular response to interferon-beta (GO:0035458)2.63424675
150adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.63382582
151positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62729239
152eosinophil migration (GO:0072677)2.62518026
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61447163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.93452334
2IRF8_22096565_ChIP-ChIP_GC-B_Human6.67725125
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.94358468
4IRF8_27001747_Chip-Seq_BMDM_Mouse4.48699263
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.10786178
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.09071577
7Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.74616331
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.65079065
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.55086502
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.83508544
11RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.79599020
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.78087712
13MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71060273
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.53132691
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.40010260
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.25179016
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24575959
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.21888227
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.10783536
20BRD4_27068464_Chip-Seq_AML-cells_Mouse2.06267357
21PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse2.05771482
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.02293715
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.00128746
24SPI1_23547873_ChIP-Seq_NB4_Human1.91815042
25SMAD_19615063_ChIP-ChIP_OVARY_Human1.84356673
26SPI1_23127762_ChIP-Seq_K562_Human1.73669887
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.73135646
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.70874915
29VDR_24787735_ChIP-Seq_THP-1_Human1.69463856
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.68634568
31PU_27001747_Chip-Seq_BMDM_Mouse1.67300940
32PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62677674
33CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.62118371
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.61904907
35VDR_24763502_ChIP-Seq_THP-1_Human1.52986207
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.52793859
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.51408087
38GATA2_21666600_ChIP-Seq_HMVEC_Human1.49740870
39PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.47578450
40* RXR_22158963_ChIP-Seq_LIVER_Mouse1.46189198
41VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.42184016
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41364990
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.39287911
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.37959486
45MYB_26560356_Chip-Seq_TH2_Human1.35762127
46SCL_19346495_ChIP-Seq_HPC-7_Human1.34607936
47LXR_22158963_ChIP-Seq_LIVER_Mouse1.34317747
48MAF_26560356_Chip-Seq_TH1_Human1.34084353
49TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33213854
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32400277
51RUNX_20019798_ChIP-Seq_JUKART_Human1.31695866
52* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31579204
53CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.30081290
54CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.29949715
55RARG_19884340_ChIP-ChIP_MEFs_Mouse1.26435300
56GATA1_22025678_ChIP-Seq_K562_Human1.25719017
57PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24463499
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23832469
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.20039746
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20016067
61FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17213094
62* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15837097
63GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14864300
64STAT1_20625510_ChIP-Seq_HELA_Human1.14129968
65VDR_21846776_ChIP-Seq_THP-1_Human1.13989217
66MYB_26560356_Chip-Seq_TH1_Human1.13679616
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13343902
68* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13241061
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.11115422
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.10980304
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.08622071
72GATA3_26560356_Chip-Seq_TH2_Human1.07064097
73EGR1_19032775_ChIP-ChIP_M12_Human1.06567792
74* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06130146
75LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05165764
76ELK3_25401928_ChIP-Seq_HUVEC_Human1.03490105
77SOX2_20726797_ChIP-Seq_SW620_Human1.02277121
78GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99327184
79GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98951022
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.98749565
81SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98674485
82SMRT_27268052_Chip-Seq_Bcells_Human0.98137485
83* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97600456
84CDX2_19796622_ChIP-Seq_MESCs_Mouse0.97297396
85TFEB_21752829_ChIP-Seq_HELA_Human0.92112813
86BCL6_27268052_Chip-Seq_Bcells_Human0.91960207
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.90319588
88GATA3_27048872_Chip-Seq_THYMUS_Human0.90316567
89BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.90311024
90TRIM28_21343339_ChIP-Seq_HEK293_Human0.89926105
91ZNF274_21170338_ChIP-Seq_K562_Hela0.88817086
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.87455372
93FOXO3_23340844_ChIP-Seq_DLD1_Human0.85792223
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.84232162
95UTX_26944678_Chip-Seq_JUKART_Human0.83801907
96* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83660589
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.83505660
98CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82802917
99CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82710154
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81287872
101IKZF1_21737484_ChIP-ChIP_HCT116_Human0.80503497
102P63_26484246_Chip-Seq_KERATINOCYTES_Human0.80026827
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.79415854
104GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79245589
105CJUN_26792858_Chip-Seq_BT549_Human0.77340427
106TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.76953830
107GATA2_19941826_ChIP-Seq_K562_Human0.76928073
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76592140
109NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75153749
110NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75153749
111JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.73988540
112GATA1_19941826_ChIP-Seq_K562_Human0.73796517
113TCF7_22412390_ChIP-Seq_EML_Mouse0.72970817
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.72940486
115MAF_26560356_Chip-Seq_TH2_Human0.72365060
116BCOR_27268052_Chip-Seq_Bcells_Human0.72070033
117RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.71798163
118SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.71713028
119GATA3_21878914_ChIP-Seq_MCF-7_Human0.71401550
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71365919
121* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70491529
122P300_27268052_Chip-Seq_Bcells_Human0.68529908
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.67408413
124GATA3_26560356_Chip-Seq_TH1_Human0.66775120
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.66652906
126PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.65417993
127EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.65410334
128* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.64143673
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.61789126
130TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.61474325
131MYC_19829295_ChIP-Seq_ESCs_Human0.61448598

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.34122967
2MP0001835_abnormal_antigen_presentation4.14757335
3MP0003436_decreased_susceptibility_to3.57917167
4MP0006082_CNS_inflammation3.36001505
5MP0003724_increased_susceptibility_to3.01409178
6MP0002148_abnormal_hypersensitivity_rea2.99872467
7MP0003303_peritoneal_inflammation2.97103328
8MP0009785_altered_susceptibility_to2.94928483
9MP0002419_abnormal_innate_immunity2.92949663
10MP0005000_abnormal_immune_tolerance2.76635088
11MP0003172_abnormal_lysosome_physiology2.75415864
12MP0009840_abnormal_foam_cell2.74885737
13MP0001790_abnormal_immune_system2.59413370
14MP0005387_immune_system_phenotype2.59413370
15MP0005025_abnormal_response_to2.58269526
16MP0000685_abnormal_immune_system2.30404157
17MP0002452_abnormal_antigen_presenting2.30156446
18MP0003191_abnormal_cellular_cholesterol2.28421026
19MP0004510_myositis2.22909578
20MP0001800_abnormal_humoral_immune2.14379523
21MP0001533_abnormal_skeleton_physiology2.13109940
22MP0002723_abnormal_immune_serum2.11823649
23MP0005671_abnormal_response_to1.99478249
24MP0005464_abnormal_platelet_physiology1.91541701
25MP0000569_abnormal_digit_pigmentation1.89851051
26MP0003300_gastrointestinal_ulcer1.89560879
27MP0001819_abnormal_immune_cell1.86451035
28MP0002420_abnormal_adaptive_immunity1.82905244
29MP0001845_abnormal_inflammatory_respons1.72884328
30MP0009764_decreased_sensitivity_to1.72635014
31MP0000343_altered_response_to1.72218025
32MP0008469_abnormal_protein_level1.71101559
33MP0004947_skin_inflammation1.69231936
34MP0002405_respiratory_system_inflammati1.67683655
35MP0003448_altered_tumor_morphology1.66965461
36MP0006054_spinal_hemorrhage1.63336313
37MP0005310_abnormal_salivary_gland1.61994399
38MP0000604_amyloidosis1.61151445
39MP0003646_muscle_fatigue1.54460849
40MP0002998_abnormal_bone_remodeling1.53518637
41MP0003690_abnormal_glial_cell1.52835498
42MP0008004_abnormal_stomach_pH1.45842247
43MP0005360_urolithiasis1.45462396
44MP0010155_abnormal_intestine_physiology1.45334621
45MP0003075_altered_response_to1.44398871
46MP0001853_heart_inflammation1.42552811
47MP0008438_abnormal_cutaneous_collagen1.39221711
48MP0002166_altered_tumor_susceptibility1.34366130
49MP0009333_abnormal_splenocyte_physiolog1.29724286
50MP0002138_abnormal_hepatobiliary_system1.29278569
51MP0000716_abnormal_immune_system1.29036805
52MP0005451_abnormal_body_composition1.28717550
53MP0009278_abnormal_bone_marrow1.25387656
54MP0002006_tumorigenesis1.23295814
55MP0000858_altered_metastatic_potential1.20804712
56MP0005257_abnormal_intraocular_pressure1.19901606
57MP0002332_abnormal_exercise_endurance1.18421991
58MP0003195_calcinosis1.17974795
59MP0001958_emphysema1.17001060
60MP0010307_abnormal_tumor_latency1.15294788
61MP0000689_abnormal_spleen_morphology1.14074763
62MP0005167_abnormal_blood-brain_barrier1.11527676
63MP0003806_abnormal_nucleotide_metabolis1.11284347
64MP0003186_abnormal_redox_activity1.11159528
65MP0005166_decreased_susceptibility_to1.10499918
66MP0002136_abnormal_kidney_physiology1.10368311
67MP0002398_abnormal_bone_marrow1.09825316
68MP0003566_abnormal_cell_adhesion1.06833700
69MP0003183_abnormal_peptide_metabolism1.05038028
70MP0004019_abnormal_vitamin_homeostasis1.04738154
71MP0009763_increased_sensitivity_to1.04192768
72MP0002429_abnormal_blood_cell1.04140736
73MP0003705_abnormal_hypodermis_morpholog1.04063634
74MP0003763_abnormal_thymus_physiology1.03793229
75MP0005174_abnormal_tail_pigmentation1.03295726
76MP0004782_abnormal_surfactant_physiolog1.01757755
77MP0001851_eye_inflammation1.00983375
78MP0001663_abnormal_digestive_system1.00532523
79MP0009643_abnormal_urine_homeostasis0.99593130
80MP0005390_skeleton_phenotype0.98591613
81MP0002277_abnormal_respiratory_mucosa0.97269697
82MP0002254_reproductive_system_inflammat0.96821141
83MP0002722_abnormal_immune_system0.95604786
84MP0002933_joint_inflammation0.94187873
85MP0005164_abnormal_response_to0.88256627
86MP0004043_abnormal_pH_regulation0.86802338
87MP0001545_abnormal_hematopoietic_system0.86197729
88MP0005397_hematopoietic_system_phenotyp0.86197729
89MP0000249_abnormal_blood_vessel0.86126832
90MP0001501_abnormal_sleep_pattern0.85463422
91MP0000609_abnormal_liver_physiology0.84716387
92MP0003828_pulmonary_edema0.80917273
93MP0005076_abnormal_cell_differentiation0.79292157
94MP0009765_abnormal_xenobiotic_induced0.78332515
95MP0000465_gastrointestinal_hemorrhage0.77797026
96MP0005319_abnormal_enzyme/_coenzyme0.77784686
97MP0000371_diluted_coat_color0.77263807
98MP0001756_abnormal_urination0.76947541
99MP0005647_abnormal_sex_gland0.75004131
100MP0002693_abnormal_pancreas_physiology0.74535765
101MP0003795_abnormal_bone_structure0.73890859
102MP0010329_abnormal_lipoprotein_level0.72497002
103MP0001542_abnormal_bone_strength0.71347713
104MP0004883_abnormal_blood_vessel0.71075839
105MP0001873_stomach_inflammation0.70457598
106MP0008875_abnormal_xenobiotic_pharmacok0.70413733
107MP0002139_abnormal_hepatobiliary_system0.70082666
108MP0005083_abnormal_biliary_tract0.69703992
109MP0005670_abnormal_white_adipose0.69366181
110MP0005332_abnormal_amino_acid0.69083970
111MP0005084_abnormal_gallbladder_morpholo0.67559589
112MP0005365_abnormal_bile_salt0.66966781
113MP0003091_abnormal_cell_migration0.65144402
114MP0003453_abnormal_keratinocyte_physiol0.65029736
115MP0000015_abnormal_ear_pigmentation0.63772994
116MP0005165_increased_susceptibility_to0.62234540
117MP0003045_fibrosis0.62125388
118MP0003656_abnormal_erythrocyte_physiolo0.62115202
119MP0005584_abnormal_enzyme/coenzyme_acti0.62057699
120MP0001986_abnormal_taste_sensitivity0.60634010
121MP0005535_abnormal_body_temperature0.56233192
122MP0005410_abnormal_fertilization0.56030947
123MP0000920_abnormal_myelination0.55477030
124MP0003866_abnormal_defecation0.55157050
125MP0001764_abnormal_homeostasis0.55059762

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.20823871
2Systemic lupus erythematosus (HP:0002725)6.18071190
3Vacuolated lymphocytes (HP:0001922)5.88660225
4Increased cerebral lipofuscin (HP:0011813)5.55622872
5Recurrent bacterial skin infections (HP:0005406)5.54029245
6Eczematoid dermatitis (HP:0000976)5.50695862
7Recurrent gram-negative bacterial infections (HP:0005420)4.94546371
8Increased neuronal autofluorescent lipopigment (HP:0002074)4.88383723
9Abnormality of macrophages (HP:0004311)4.85988850
10Autoimmune thrombocytopenia (HP:0001973)4.32865457
11Glomerulonephritis (HP:0000099)4.30905542
12Dysostosis multiplex (HP:0000943)4.29694063
13Axonal loss (HP:0003447)3.95788933
14Abnormality of liposaccharide metabolism (HP:0010968)3.86755366
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.86755366
16Abnormality of glycolipid metabolism (HP:0010969)3.86755366
17Urinary glycosaminoglycan excretion (HP:0003541)3.76220182
18Mucopolysacchariduria (HP:0008155)3.76220182
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.61034173
20Abnormality of polysaccharide metabolism (HP:0011012)3.61034173
21Abnormality of glycosaminoglycan metabolism (HP:0004371)3.61034173
22Gingivitis (HP:0000230)3.57556240
23Disinhibition (HP:0000734)3.45054127
24Keratoconjunctivitis (HP:0001096)3.40278961
25Keratoconjunctivitis sicca (HP:0001097)3.38514789
26Mediastinal lymphadenopathy (HP:0100721)3.38154573
27Recurrent skin infections (HP:0001581)3.36212708
28Myositis (HP:0100614)3.32958333
29Elevated erythrocyte sedimentation rate (HP:0003565)3.26703374
30Loss of speech (HP:0002371)3.23307889
31Orchitis (HP:0100796)3.23111677
32Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.20426086
33Complement deficiency (HP:0004431)3.11119040
34Chronic obstructive pulmonary disease (HP:0006510)3.10980706
35Obstructive lung disease (HP:0006536)3.10980706
36Abnormality of complement system (HP:0005339)3.06240702
37Nephritis (HP:0000123)3.03426797
38Myocardial infarction (HP:0001658)2.98417967
39Prostate neoplasm (HP:0100787)2.96359410
40Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.95868617
41Recurrent fungal infections (HP:0002841)2.89058844
42Basal ganglia calcification (HP:0002135)2.85063586
43Stomatitis (HP:0010280)2.82310574
44Mutism (HP:0002300)2.78236191
45Periodontitis (HP:0000704)2.73284461
46Optic neuritis (HP:0100653)2.68929135
47Retrobulbar optic neuritis (HP:0100654)2.68929135
48Thick nail (HP:0001805)2.68306668
49Encephalitis (HP:0002383)2.67748644
50Pustule (HP:0200039)2.62417273
51Gangrene (HP:0100758)2.58893040
52Abnormality of T cell number (HP:0011839)2.58709331
53Interstitial pulmonary disease (HP:0006530)2.58701339
54T lymphocytopenia (HP:0005403)2.58201731
55Pathologic fracture (HP:0002756)2.54501060
56Vasculitis (HP:0002633)2.53848523
57Urticaria (HP:0001025)2.51708330
58Hepatosplenomegaly (HP:0001433)2.49425686
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.47706244
60Abnormality of B cell number (HP:0010975)2.47640748
61Polyneuropathy (HP:0001271)2.46878825
62Nausea (HP:0002018)2.45792032
63Recurrent viral infections (HP:0004429)2.44251038
64Gastrointestinal infarctions (HP:0005244)2.43283813
65Abnormal delayed hypersensitivity skin test (HP:0002963)2.37784202
66Agnosia (HP:0010524)2.36753807
67Bone pain (HP:0002653)2.35511319
68Abnormality of the pleura (HP:0002103)2.34088323
69Tetraparesis (HP:0002273)2.33759473
70Spontaneous hematomas (HP:0007420)2.32662965
71Hematochezia (HP:0002573)2.32149225
72Progressive visual loss (HP:0000529)2.26628701
73Autoimmune hemolytic anemia (HP:0001890)2.24893057
74Joint hemorrhage (HP:0005261)2.22180835
75Osteolytic defects of the phalanges of the hand (HP:0009771)2.21059714
76Osteolytic defects of the hand bones (HP:0009699)2.21059714
77Pulmonary embolism (HP:0002204)2.20765862
78Cellulitis (HP:0100658)2.20035043
79Upper motor neuron abnormality (HP:0002127)2.19289357
80Chronic otitis media (HP:0000389)2.18326664
81J-shaped sella turcica (HP:0002680)2.17849119
82Abnormality of iron homeostasis (HP:0011031)2.17745828
83Abnormality of transition element cation homeostasis (HP:0011030)2.15609589
84Mesangial abnormality (HP:0001966)2.13802536
85Osteomyelitis (HP:0002754)2.13548698
86Abnormality of proline metabolism (HP:0010907)2.12142814
87Hydroxyprolinuria (HP:0003080)2.12142814
88Parakeratosis (HP:0001036)2.11433659
89Metaphyseal irregularity (HP:0003025)2.10768971
90Peripheral demyelination (HP:0011096)2.08991636
91Increased IgM level (HP:0003496)2.08926941
92Purpura (HP:0000979)2.08010553
93Conjunctival telangiectasia (HP:0000524)2.06217973
94Premature loss of primary teeth (HP:0006323)2.06037684
95Vertebral compression fractures (HP:0002953)2.04580215
96Recurrent cutaneous fungal infections (HP:0011370)2.04480493
97Chronic mucocutaneous candidiasis (HP:0002728)2.04480493
98Vertigo (HP:0002321)2.04082750
99Abnormality of glutamine family amino acid metabolism (HP:0010902)2.03411423
100Joint swelling (HP:0001386)2.02975729
101Episodic fever (HP:0001954)2.02843072
102Abnormality of the pericardium (HP:0001697)2.02121570
103B lymphocytopenia (HP:0010976)2.02101445
104Pulmonary infiltrates (HP:0002113)2.00584189
105Keratitis (HP:0000491)2.00050827
106Leukocytosis (HP:0001974)1.99994752
107Gingival bleeding (HP:0000225)1.98561020
108Eosinophilia (HP:0001880)1.97986103
109Esophageal varix (HP:0002040)1.97073434
110Asymmetric septal hypertrophy (HP:0001670)1.95177464
111Abnormality of T cells (HP:0002843)1.94499500
112Albinism (HP:0001022)1.93886975
113Recurrent pneumonia (HP:0006532)1.93688524
114Abnormality of the endocardium (HP:0004306)1.91092093
115Petechiae (HP:0000967)1.90164071
116Arterial thrombosis (HP:0004420)1.90062216
117Anorexia (HP:0002039)1.88962633
118Abnormality of eosinophils (HP:0001879)1.86373924
119Acne (HP:0001061)1.85966871
120Abnormality of the lumbar spine (HP:0100712)1.85681532
121Alveolar cell carcinoma (HP:0006519)1.85282864
122Amyloidosis (HP:0011034)1.84776829
123Hypergammaglobulinemia (HP:0010702)1.83956264
124Abnormality of the nasal mucosa (HP:0000433)1.83196054
125Granulocytopenia (HP:0001913)1.79267676
126Inappropriate behavior (HP:0000719)1.78877826
127Increased serum ferritin (HP:0003281)1.78778301
128Arthralgia (HP:0002829)1.77779043
129Abolished electroretinogram (ERG) (HP:0000550)1.77202343
130Glomerulopathy (HP:0100820)1.77044146
131Nasal polyposis (HP:0100582)1.76657101
132Stomach cancer (HP:0012126)1.76607729
133Colitis (HP:0002583)1.76370588
134Abnormality of the prostate (HP:0008775)1.75618969
135Meningitis (HP:0001287)1.75281398
136Thoracic kyphosis (HP:0002942)1.74577482
137Hypercholesterolemia (HP:0003124)1.73127581
138Diminished motivation (HP:0000745)1.72851059
139Hemoptysis (HP:0002105)1.72019560
140Neoplasm of head and neck (HP:0012288)1.71375981

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.85975045
2TYK23.71457965
3MAP3K143.57152702
4TBK13.50335076
5ERN13.27418809
6IRAK33.21463038
7KIT3.06773218
8RIPK43.00447724
9IRAK42.86350778
10IKBKE2.66816438
11MAP4K12.46808806
12FRK2.38849168
13JAK12.31592480
14PBK2.19941853
15TGFBR22.12949625
16IKBKB2.08783236
17JAK32.08513589
18ACVR1B1.80547983
19PIM21.79760135
20EPHB11.79106178
21KDR1.73607824
22TXK1.63084580
23NEK91.60613231
24CSK1.60374179
25FGFR41.58678562
26ZAP701.56056698
27DDR21.55233905
28TAOK31.46849840
29CDC42BPA1.41583664
30MST1R1.40307870
31NME21.36937132
32HCK1.29669292
33SYK1.26809660
34TLK11.26639160
35BMX1.26360182
36MAP4K21.25240063
37MAP3K131.23575509
38CSF1R1.22606273
39CHUK1.22502098
40TAOK21.19779221
41JAK21.18768292
42TAOK11.17489501
43CAMK1D1.17371928
44LYN1.13454337
45ABL21.12967297
46RIPK11.10574995
47LCK1.02125155
48FGR0.99405837
49MAP2K30.98438121
50FES0.97306053
51STK100.95869703
52MATK0.93872937
53FGFR30.93538269
54BTK0.92165704
55MAP2K60.91059070
56GRK70.90728193
57TNK20.90068034
58BMPR20.89757184
59RPS6KA40.89198175
60MST40.88645185
61PIM10.85728491
62EPHA30.84175491
63PTK60.83258917
64MAP3K30.82734682
65TEC0.81494169
66PRKCD0.75020463
67EGFR0.74727405
68TRIB30.71995189
69DAPK20.71131458
70GRK10.69680419
71IRAK10.67871104
72ABL10.67074515
73MARK30.65977461
74PRKCQ0.65744232
75TTN0.65485294
76WNK40.63507061
77STK30.61268681
78LRRK20.60292312
79CAMK1G0.58690097
80MAP3K50.56137073
81PRKAA20.56045436
82PDK10.55134230
83MAP3K110.54326523
84TRPM70.53138984
85STK40.51053257
86MOS0.49909882
87PKN10.49608347
88SIK20.48548034
89CDK60.48511162
90SCYL20.47565473
91EIF2AK20.47470329
92PAK40.45549554
93HIPK20.45057923
94INSRR0.44881942
95ADRBK10.43595716
96ITK0.43125223
97CLK10.42843774
98ARAF0.40962966
99TIE10.40832547
100GRK60.40146185
101TGFBR10.39495553
102TESK10.39416242
103IGF1R0.38969349
104PRKG20.38380732
105MAP3K10.37180189
106OXSR10.36744249
107IRAK20.35003239
108CAMKK20.34899876
109MAPKAPK30.33820461
110MAPKAPK20.33104576
111FYN0.32715906
112PIK3CG0.32052621
113ADRBK20.31265349
114GSK3A0.31254486
115PDPK10.29988372
116MAP2K20.29820487
117MAPK40.29187978
118STK240.28742911
119PRKD20.28718403
120INSR0.27710019
121NUAK10.27648514
122WNK30.27551404
123MAPK70.26159071
124YES10.25965731
125ZAK0.25708649
126ERBB30.25700418
127BCKDK0.25478821
128PKN20.25426335
129BMPR1B0.24669307
130MAPK110.24580221
131CDK120.23954335
132PTK2B0.23859821

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.06811827
2Lysosome_Homo sapiens_hsa041423.22061908
3Glycosaminoglycan degradation_Homo sapiens_hsa005313.05584290
4Leishmaniasis_Homo sapiens_hsa051403.03847934
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.73953676
6Other glycan degradation_Homo sapiens_hsa005112.66897088
7Osteoclast differentiation_Homo sapiens_hsa043802.34733591
8Pertussis_Homo sapiens_hsa051332.32639979
9Malaria_Homo sapiens_hsa051442.19315924
10Tuberculosis_Homo sapiens_hsa051522.17410569
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.08786681
12Rheumatoid arthritis_Homo sapiens_hsa053232.04634401
13Legionellosis_Homo sapiens_hsa051341.99276062
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.94533406
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.91295342
16Phagosome_Homo sapiens_hsa041451.86075417
17Measles_Homo sapiens_hsa051621.85095972
18Graft-versus-host disease_Homo sapiens_hsa053321.84522035
19Allograft rejection_Homo sapiens_hsa053301.81905660
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.68168485
21Influenza A_Homo sapiens_hsa051641.67204329
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63305855
23Complement and coagulation cascades_Homo sapiens_hsa046101.61433852
24NOD-like receptor signaling pathway_Homo sapiens_hsa046211.61184821
25Caffeine metabolism_Homo sapiens_hsa002321.58814839
26Antigen processing and presentation_Homo sapiens_hsa046121.50351357
27Toxoplasmosis_Homo sapiens_hsa051451.50188715
28Asthma_Homo sapiens_hsa053101.50097150
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.44757069
30Salmonella infection_Homo sapiens_hsa051321.43691310
31TNF signaling pathway_Homo sapiens_hsa046681.39417880
32Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35097076
33B cell receptor signaling pathway_Homo sapiens_hsa046621.34950297
34Apoptosis_Homo sapiens_hsa042101.31109983
35Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.26591533
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21677520
37Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.19920445
38Shigellosis_Homo sapiens_hsa051311.19912360
39Herpes simplex infection_Homo sapiens_hsa051681.19382551
40Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.13753817
41Jak-STAT signaling pathway_Homo sapiens_hsa046301.12846944
42Hepatitis C_Homo sapiens_hsa051601.11648091
43Collecting duct acid secretion_Homo sapiens_hsa049661.11596422
44Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10961674
45African trypanosomiasis_Homo sapiens_hsa051431.09088146
46Hematopoietic cell lineage_Homo sapiens_hsa046401.08589888
47Chemokine signaling pathway_Homo sapiens_hsa040621.08321550
48Mineral absorption_Homo sapiens_hsa049781.04414098
49Viral myocarditis_Homo sapiens_hsa054160.91990938
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89407574
51Renin-angiotensin system_Homo sapiens_hsa046140.88959659
52Sphingolipid metabolism_Homo sapiens_hsa006000.84843496
53Hepatitis B_Homo sapiens_hsa051610.83871396
54Leukocyte transendothelial migration_Homo sapiens_hsa046700.83844859
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83670816
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83614750
57Amoebiasis_Homo sapiens_hsa051460.81297714
58Autoimmune thyroid disease_Homo sapiens_hsa053200.78367493
59Prion diseases_Homo sapiens_hsa050200.76823357
60AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74705288
61Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74528199
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73438465
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.73436579
64Vitamin digestion and absorption_Homo sapiens_hsa049770.70027731
65Tryptophan metabolism_Homo sapiens_hsa003800.68204947
66Type I diabetes mellitus_Homo sapiens_hsa049400.67894809
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.67654922
68PPAR signaling pathway_Homo sapiens_hsa033200.66989532
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66976058
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66789779
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63978517
72Ether lipid metabolism_Homo sapiens_hsa005650.63834805
73Primary immunodeficiency_Homo sapiens_hsa053400.62139107
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59850935
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.51127516
76Pancreatic cancer_Homo sapiens_hsa052120.49817668
77Acute myeloid leukemia_Homo sapiens_hsa052210.49002568
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48630526
79Histidine metabolism_Homo sapiens_hsa003400.47683766
80Sulfur metabolism_Homo sapiens_hsa009200.47539588
81Peroxisome_Homo sapiens_hsa041460.46080027
82Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45599172
83Starch and sucrose metabolism_Homo sapiens_hsa005000.44822457
84ABC transporters_Homo sapiens_hsa020100.42975553
85Galactose metabolism_Homo sapiens_hsa000520.42141493
86Platelet activation_Homo sapiens_hsa046110.41598874
87Chronic myeloid leukemia_Homo sapiens_hsa052200.40765846
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40073093
89Endocytosis_Homo sapiens_hsa041440.39726896
90Dorso-ventral axis formation_Homo sapiens_hsa043200.38826782
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38323926
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38296639
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.36458905
94Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36396078
95T cell receptor signaling pathway_Homo sapiens_hsa046600.36278936
96Sphingolipid signaling pathway_Homo sapiens_hsa040710.35926605
97Steroid biosynthesis_Homo sapiens_hsa001000.35428068
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35240507
99Prolactin signaling pathway_Homo sapiens_hsa049170.34821360
100Type II diabetes mellitus_Homo sapiens_hsa049300.30961205
101Arachidonic acid metabolism_Homo sapiens_hsa005900.30717793
102Systemic lupus erythematosus_Homo sapiens_hsa053220.29749665
103Linoleic acid metabolism_Homo sapiens_hsa005910.29650369
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27052941
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25733136
106Bladder cancer_Homo sapiens_hsa052190.25664426
107Glycerolipid metabolism_Homo sapiens_hsa005610.24393831
108beta-Alanine metabolism_Homo sapiens_hsa004100.24261567
109Small cell lung cancer_Homo sapiens_hsa052220.23288931
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23039023
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.21888742
112Proteoglycans in cancer_Homo sapiens_hsa052050.21560541
113Insulin resistance_Homo sapiens_hsa049310.21555607
114Notch signaling pathway_Homo sapiens_hsa043300.21397884
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20497055
116VEGF signaling pathway_Homo sapiens_hsa043700.19693527
117Ovarian steroidogenesis_Homo sapiens_hsa049130.19265111
118Pentose phosphate pathway_Homo sapiens_hsa000300.18164856
119Epstein-Barr virus infection_Homo sapiens_hsa051690.17918412
120MAPK signaling pathway_Homo sapiens_hsa040100.14591513
121HTLV-I infection_Homo sapiens_hsa051660.14028416
122Regulation of autophagy_Homo sapiens_hsa041400.13801375
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13794140
124FoxO signaling pathway_Homo sapiens_hsa040680.11007963
125Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.10262895

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