TMEM106B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.30320453
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.30320453
3L-phenylalanine metabolic process (GO:0006558)4.99782384
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.99782384
5aromatic amino acid family catabolic process (GO:0009074)4.54026121
6alpha-linolenic acid metabolic process (GO:0036109)4.42721967
7lysine metabolic process (GO:0006553)4.12206481
8lysine catabolic process (GO:0006554)4.12206481
9triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.04395453
10bile acid biosynthetic process (GO:0006699)4.00674081
11glyoxylate metabolic process (GO:0046487)3.98926712
12cysteine metabolic process (GO:0006534)3.95819266
13kynurenine metabolic process (GO:0070189)3.88055651
14tryptophan catabolic process (GO:0006569)3.83399092
15indole-containing compound catabolic process (GO:0042436)3.83399092
16indolalkylamine catabolic process (GO:0046218)3.83399092
17glutamate metabolic process (GO:0006536)3.78633136
18cellular ketone body metabolic process (GO:0046950)3.72040586
19dicarboxylic acid biosynthetic process (GO:0043650)3.69807805
20short-chain fatty acid metabolic process (GO:0046459)3.64377927
21tryptophan metabolic process (GO:0006568)3.64092195
22sulfur amino acid catabolic process (GO:0000098)3.62687883
23fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.61559696
24negative regulation of cytosolic calcium ion concentration (GO:0051481)3.49608681
25negative regulation of fibrinolysis (GO:0051918)3.44893840
26urea metabolic process (GO:0019627)3.44082874
27urea cycle (GO:0000050)3.44082874
28homocysteine metabolic process (GO:0050667)3.43055571
29bile acid metabolic process (GO:0008206)3.41403515
30peptidyl-glutamic acid carboxylation (GO:0017187)3.38215560
31protein carboxylation (GO:0018214)3.38215560
32high-density lipoprotein particle remodeling (GO:0034375)3.37588149
33cellular modified amino acid catabolic process (GO:0042219)3.36104052
34tyrosine metabolic process (GO:0006570)3.35824372
35complement activation, alternative pathway (GO:0006957)3.34531849
36aspartate family amino acid catabolic process (GO:0009068)3.34524104
37reflex (GO:0060004)3.34292895
38neural tube formation (GO:0001841)3.32767743
39regulation of protein activation cascade (GO:2000257)3.31223196
40ketone body metabolic process (GO:1902224)3.30610348
41detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27640808
42alpha-amino acid catabolic process (GO:1901606)3.27635709
43amino-acid betaine metabolic process (GO:0006577)3.27369571
44aromatic amino acid family metabolic process (GO:0009072)3.24216991
45regulation of fibrinolysis (GO:0051917)3.23389337
46drug transmembrane transport (GO:0006855)3.22604905
47serine family amino acid catabolic process (GO:0009071)3.21609550
48signal peptide processing (GO:0006465)3.20970414
49behavioral response to nicotine (GO:0035095)3.20438655
50coenzyme catabolic process (GO:0009109)3.19681853
51cellular amino acid catabolic process (GO:0009063)3.15110921
52nitrogen cycle metabolic process (GO:0071941)3.14404338
53regulation of complement activation (GO:0030449)3.12236595
54acetyl-CoA metabolic process (GO:0006084)3.11581961
55drug catabolic process (GO:0042737)3.10730122
56reverse cholesterol transport (GO:0043691)3.09300167
572-oxoglutarate metabolic process (GO:0006103)3.07054816
58presynaptic membrane assembly (GO:0097105)3.06425635
59positive regulation of fatty acid beta-oxidation (GO:0032000)3.06242516
60regulation of triglyceride catabolic process (GO:0010896)3.05717206
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.05263777
62regulation of hippo signaling (GO:0035330)3.02968413
63serotonin metabolic process (GO:0042428)3.02794282
64dicarboxylic acid catabolic process (GO:0043649)3.01200475
65plasma lipoprotein particle remodeling (GO:0034369)2.99966629
66protein-lipid complex remodeling (GO:0034368)2.99966629
67macromolecular complex remodeling (GO:0034367)2.99966629
68establishment of protein localization to Golgi (GO:0072600)2.97530726
69fatty acid beta-oxidation (GO:0006635)2.94877804
70acylglycerol homeostasis (GO:0055090)2.94292697
71triglyceride homeostasis (GO:0070328)2.94292697
72ethanol oxidation (GO:0006069)2.94144074
73epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.92635041
74plasma lipoprotein particle clearance (GO:0034381)2.91298038
75cellular glucuronidation (GO:0052695)2.91257053
76fatty acid oxidation (GO:0019395)2.89467809
77regulation of cholesterol esterification (GO:0010872)2.88634801
78primary amino compound metabolic process (GO:1901160)2.88417899
79lipid oxidation (GO:0034440)2.86138252
80regulation of cholesterol homeostasis (GO:2000188)2.82629714
81monocarboxylic acid catabolic process (GO:0072329)2.82540217
82negative regulation of cholesterol transport (GO:0032375)2.82115417
83negative regulation of sterol transport (GO:0032372)2.82115417
84positive regulation of lipid catabolic process (GO:0050996)2.80676872
85exogenous drug catabolic process (GO:0042738)2.80583543
86presynaptic membrane organization (GO:0097090)2.79347734
87organic acid catabolic process (GO:0016054)2.79166674
88carboxylic acid catabolic process (GO:0046395)2.79166674
89fatty acid catabolic process (GO:0009062)2.79090896
90urate metabolic process (GO:0046415)2.75056149
91phospholipid homeostasis (GO:0055091)2.74964559
92response to mercury ion (GO:0046689)2.74041459
93gamma-aminobutyric acid transport (GO:0015812)2.73484074
94response to pheromone (GO:0019236)2.72808063
95indolalkylamine metabolic process (GO:0006586)2.71839337
96benzene-containing compound metabolic process (GO:0042537)2.71421688
97negative regulation of lipase activity (GO:0060192)2.70847388
98positive regulation of fatty acid oxidation (GO:0046321)2.70757726
99phospholipid efflux (GO:0033700)2.69975221
100valine metabolic process (GO:0006573)2.69695572
101cholesterol efflux (GO:0033344)2.69452626
102righting reflex (GO:0060013)2.69045289
103inner ear receptor stereocilium organization (GO:0060122)2.68204117
104regulation of fatty acid beta-oxidation (GO:0031998)2.67921151
105very long-chain fatty acid metabolic process (GO:0000038)2.67531547
106cellular response to sterol (GO:0036315)2.66585017
107limb development (GO:0060173)2.66268756
108appendage development (GO:0048736)2.66268756
109nonmotile primary cilium assembly (GO:0035058)2.65804594
110bile acid and bile salt transport (GO:0015721)2.64785186
111L-fucose catabolic process (GO:0042355)2.63427486
112fucose catabolic process (GO:0019317)2.63427486
113L-fucose metabolic process (GO:0042354)2.63427486
114limb bud formation (GO:0060174)2.62797507
115kidney morphogenesis (GO:0060993)2.62552228
116regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62127842
117negative regulation of neurotransmitter transport (GO:0051589)2.62089377
118epoxygenase P450 pathway (GO:0019373)2.62014138
119regulation of bile acid biosynthetic process (GO:0070857)2.61440520
120positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.61298331
121low-density lipoprotein particle remodeling (GO:0034374)2.60086273
122thyroid hormone metabolic process (GO:0042403)2.59587118
123auditory receptor cell stereocilium organization (GO:0060088)2.58473956
124glucuronate metabolic process (GO:0019585)2.57430496
125uronic acid metabolic process (GO:0006063)2.57430496
126photoreceptor cell maintenance (GO:0045494)2.57117896
127negative regulation of protein activation cascade (GO:2000258)2.55784003
128detection of light stimulus involved in visual perception (GO:0050908)2.55303158
129detection of light stimulus involved in sensory perception (GO:0050962)2.55303158
130carnitine metabolic process (GO:0009437)2.54414781
131epithelial cilium movement (GO:0003351)2.54357036
132oxidative demethylation (GO:0070989)2.54289423
133fatty acid transmembrane transport (GO:1902001)2.53947578
134protein K11-linked deubiquitination (GO:0035871)2.53682920
135regulation of cholesterol metabolic process (GO:0090181)2.53581810
136transmission of nerve impulse (GO:0019226)2.52285498
137cilium morphogenesis (GO:0060271)2.52247001
138succinate metabolic process (GO:0006105)2.52193420
139regulation of pigment cell differentiation (GO:0050932)2.50701724
140magnesium ion transport (GO:0015693)2.50499796
141indole-containing compound metabolic process (GO:0042430)2.49353597
142regulation of cholesterol biosynthetic process (GO:0045540)2.49048037
143proline transport (GO:0015824)2.48409397
144serine family amino acid metabolic process (GO:0009069)2.48335860
145cilium or flagellum-dependent cell motility (GO:0001539)2.47768011
146regulation of cell communication by electrical coupling (GO:0010649)2.46846518
147startle response (GO:0001964)2.46782929
148regulation of sarcomere organization (GO:0060297)2.46497550
149negative regulation of protein localization to cell surface (GO:2000009)2.45132673
150embryonic epithelial tube formation (GO:0001838)2.43705191
151cilium movement (GO:0003341)2.41859422
152cilium organization (GO:0044782)2.40416942
153relaxation of cardiac muscle (GO:0055119)2.40257738
154protein targeting to Golgi (GO:0000042)2.38676152
155cilium assembly (GO:0042384)2.36518215
156detection of mechanical stimulus involved in sensory perception (GO:0050974)2.35810846
157interkinetic nuclear migration (GO:0022027)2.35476496
158dorsal/ventral axis specification (GO:0009950)2.33442944
159neuronal action potential (GO:0019228)2.32789641
160auditory behavior (GO:0031223)2.31042352
161sulfation (GO:0051923)2.29814308
162protein targeting to lysosome (GO:0006622)2.29784726
163establishment of protein localization to vacuole (GO:0072666)2.29784726
164protein targeting to vacuole (GO:0006623)2.29784726
165regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29605120
166prostate gland growth (GO:0060736)2.29588898
167epithelial tube formation (GO:0072175)2.28816521
168somite development (GO:0061053)2.28131731
169negative regulation of systemic arterial blood pressure (GO:0003085)2.28059795
170regulation of mesoderm development (GO:2000380)2.27242743
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.26836556
172phospholipid translocation (GO:0045332)2.26297926
173lipid translocation (GO:0034204)2.26297926
174protein localization to Golgi apparatus (GO:0034067)2.25903202
175prenylation (GO:0097354)2.24753618
176protein prenylation (GO:0018342)2.24753618
177negative regulation of hormone biosynthetic process (GO:0032353)2.24460598
178cell morphogenesis involved in neuron differentiation (GO:0048667)2.23961291
179regulation of action potential (GO:0098900)2.22948118
180negative regulation of neurotransmitter secretion (GO:0046929)2.22854486
181regulation of neurotransmitter uptake (GO:0051580)2.22372538
182microtubule anchoring (GO:0034453)2.22276991
183negative regulation of sodium ion transport (GO:0010766)2.21132288
184negative regulation of astrocyte differentiation (GO:0048712)2.20939334
185vascular smooth muscle contraction (GO:0014829)2.20537718
186regulation of short-term neuronal synaptic plasticity (GO:0048172)2.19958025
187behavioral response to ethanol (GO:0048149)2.19845982
188positive regulation of cardiac muscle cell differentiation (GO:2000727)2.19267867
189central nervous system myelination (GO:0022010)2.19214026
190axon ensheathment in central nervous system (GO:0032291)2.19214026
191glycosphingolipid biosynthetic process (GO:0006688)2.19094779
192protein localization to cilium (GO:0061512)2.19077868

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.74078407
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.17954074
3* LXR_22158963_ChIP-Seq_LIVER_Mouse3.51646983
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.36871389
5POU3F2_20337985_ChIP-ChIP_501MEL_Human2.89502019
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.86862702
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.82490250
8* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.69075005
9EGR1_23403033_ChIP-Seq_LIVER_Mouse2.56252054
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.56099042
11IGF1R_20145208_ChIP-Seq_DFB_Human2.52574142
12FLI1_27457419_Chip-Seq_LIVER_Mouse2.20808236
13FUS_26573619_Chip-Seq_HEK293_Human2.14512868
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.08764663
15VDR_22108803_ChIP-Seq_LS180_Human2.05457138
16GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.02558574
17GBX2_23144817_ChIP-Seq_PC3_Human1.97630277
18EWS_26573619_Chip-Seq_HEK293_Human1.92373563
19PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85423680
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84896349
21MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.73153268
22ER_23166858_ChIP-Seq_MCF-7_Human1.70332775
23BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.68342936
24SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63714874
25UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.60506258
26EZH2_22144423_ChIP-Seq_EOC_Human1.59829799
27MTF2_20144788_ChIP-Seq_MESCs_Mouse1.58982133
28SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55875849
29TCF4_23295773_ChIP-Seq_U87_Human1.55333454
30TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51941827
31EZH2_27294783_Chip-Seq_NPCs_Mouse1.50998443
32SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50363970
33FOXA2_19822575_ChIP-Seq_HepG2_Human1.49934390
34RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49885376
35EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49885376
36DROSHA_22980978_ChIP-Seq_HELA_Human1.48070204
37NANOG_18555785_Chip-Seq_ESCs_Mouse1.47617942
38PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46576494
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45768643
40TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44886980
41CBP_20019798_ChIP-Seq_JUKART_Human1.43808225
42IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43808225
43* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.43702224
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43227651
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.40848831
46CLOCK_20551151_ChIP-Seq_293T_Human1.39916746
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39489957
48NRF2_20460467_ChIP-Seq_MEFs_Mouse1.38670218
49NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.38670218
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38643689
51SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.37638459
52NFE2_27457419_Chip-Seq_LIVER_Mouse1.37399658
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.36949546
54EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.36464833
55CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.35603299
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.33035197
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32878914
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.32825471
59JARID2_20064375_ChIP-Seq_MESCs_Mouse1.32574691
60* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32219876
61TCF4_22108803_ChIP-Seq_LS180_Human1.31969117
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.31269994
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30823592
64AR_21572438_ChIP-Seq_LNCaP_Human1.30380561
65P53_22387025_ChIP-Seq_ESCs_Mouse1.30035882
66CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.29536742
67TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29440453
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28921431
69E2F1_18555785_Chip-Seq_ESCs_Mouse1.26373925
70* RUNX2_22187159_ChIP-Seq_PCA_Human1.26231832
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.25117604
72RBPJ_22232070_ChIP-Seq_NCS_Mouse1.24269811
73KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22682050
74FLI1_21867929_ChIP-Seq_TH2_Mouse1.22680497
75TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21826113
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.21723140
77CDX2_22108803_ChIP-Seq_LS180_Human1.19632146
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.18651366
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17004713
80RNF2_27304074_Chip-Seq_NSC_Mouse1.16883152
81EP300_21415370_ChIP-Seq_HL-1_Mouse1.16877670
82CJUN_26792858_Chip-Seq_BT549_Human1.16518344
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15485159
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.15118943
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.14950601
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13250689
87TAF15_26573619_Chip-Seq_HEK293_Human1.12423093
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.12182414
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11983092
90HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11891746
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11787184
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11787184
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11765528
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11753907
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.11598462
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11449962
97NANOG_19829295_ChIP-Seq_ESCs_Human1.10708682
98SOX2_19829295_ChIP-Seq_ESCs_Human1.10708682
99CBX2_27304074_Chip-Seq_ESCs_Mouse1.10499795
100ESR2_21235772_ChIP-Seq_MCF-7_Human1.10055788
101TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09874102
102ESR1_20079471_ChIP-ChIP_T-47D_Human1.09331748
103STAT3_18555785_Chip-Seq_ESCs_Mouse1.09209119
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08793307
105SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07626975
106OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07532095
107P300_18555785_Chip-Seq_ESCs_Mouse1.07485028
108* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06799556
109TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06680966
110SMAD4_21799915_ChIP-Seq_A2780_Human1.06236205
111BCAT_22108803_ChIP-Seq_LS180_Human1.05953851
112* TAL1_26923725_Chip-Seq_HPCs_Mouse1.05878310
113EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.05402987
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05299414
115PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03243016
116TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02873156
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.02170034
118* SOX2_21211035_ChIP-Seq_LN229_Gbm1.00839239
119THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.00512337
120MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99770549
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98317356
122ARNT_22903824_ChIP-Seq_MCF-7_Human0.98165139
123GATA1_22025678_ChIP-Seq_K562_Human0.98157754
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97365499
125CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96373823
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.96120250
127AHR_22903824_ChIP-Seq_MCF-7_Human0.95751613
128EZH2_27304074_Chip-Seq_ESCs_Mouse0.95428416
129RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95406253
130TP53_16413492_ChIP-PET_HCT116_Human0.95187308
131REST_21632747_ChIP-Seq_MESCs_Mouse0.95057270
132RNF2_27304074_Chip-Seq_ESCs_Mouse0.94299393
133RXR_22108803_ChIP-Seq_LS180_Human0.94278111
134* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93859101
135CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.93237355
136AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.92374668
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.92306604
138NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91419381
139HTT_18923047_ChIP-ChIP_STHdh_Human0.90686718
140SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90671454
141AR_25329375_ChIP-Seq_VCAP_Human0.88531040
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.88329940
143STAT3_23295773_ChIP-Seq_U87_Human0.87940202
144TP53_18474530_ChIP-ChIP_U2OS_Human0.87655649
145ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87476213
146REST_18959480_ChIP-ChIP_MESCs_Mouse0.84943774
147AR_19668381_ChIP-Seq_PC3_Human0.84895881
148HNF4A_19822575_ChIP-Seq_HepG2_Human0.84865865
149ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.84733738
150* P300_19829295_ChIP-Seq_ESCs_Human0.84685067
151* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.82558734
152* CTBP2_25329375_ChIP-Seq_LNCAP_Human0.82518622
153* CTBP1_25329375_ChIP-Seq_LNCAP_Human0.81983615
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.81280313
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.81204720
156ZNF274_21170338_ChIP-Seq_K562_Hela0.79726584
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.78147387
158SMAD4_21741376_ChIP-Seq_EPCs_Human0.78030016
159* TOP2B_26459242_ChIP-Seq_MCF-7_Human0.74934059
160TBX20_22080862_ChIP-Seq_HEART_Mouse0.73683524
161TBX20_22328084_ChIP-Seq_HEART_Mouse0.73683524

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.96166738
2MP0005360_urolithiasis5.71414376
3MP0005085_abnormal_gallbladder_physiolo4.53086771
4MP0005365_abnormal_bile_salt4.35792049
5MP0008875_abnormal_xenobiotic_pharmacok3.67583629
6MP0000569_abnormal_digit_pigmentation3.28158392
7MP0003252_abnormal_bile_duct3.24414552
8MP0003195_calcinosis2.92260879
9MP0010329_abnormal_lipoprotein_level2.70491168
10MP0005332_abnormal_amino_acid2.67968008
11MP0004859_abnormal_synaptic_plasticity2.26962370
12MP0001984_abnormal_olfaction2.25171486
13MP0003806_abnormal_nucleotide_metabolis2.11499821
14MP0005083_abnormal_biliary_tract2.03514877
15MP0005551_abnormal_eye_electrophysiolog1.99393724
16MP0010386_abnormal_urinary_bladder1.92146638
17MP0001666_abnormal_nutrient_absorption1.91643935
18MP0005171_absent_coat_pigmentation1.90371146
19MP0002118_abnormal_lipid_homeostasis1.87635914
20MP0002638_abnormal_pupillary_reflex1.86476072
21MP0003329_amyloid_beta_deposits1.82567469
22MP0009840_abnormal_foam_cell1.82528039
23MP0004043_abnormal_pH_regulation1.82383850
24MP0002102_abnormal_ear_morphology1.80258398
25MP0009780_abnormal_chondrocyte_physiolo1.77776367
26MP0000383_abnormal_hair_follicle1.76695308
27MP0004215_abnormal_myocardial_fiber1.70501796
28MP0004019_abnormal_vitamin_homeostasis1.70328001
29MP0003690_abnormal_glial_cell1.64021979
30MP0003136_yellow_coat_color1.62261984
31MP0004130_abnormal_muscle_cell1.61910623
32MP0006072_abnormal_retinal_apoptosis1.60272913
33MP0005253_abnormal_eye_physiology1.58504693
34MP0010678_abnormal_skin_adnexa1.56919553
35MP0000427_abnormal_hair_cycle1.54870145
36MP0004145_abnormal_muscle_electrophysio1.53393773
37MP0003646_muscle_fatigue1.50726936
38MP0005584_abnormal_enzyme/coenzyme_acti1.48737826
39MP0002138_abnormal_hepatobiliary_system1.48245154
40MP0000604_amyloidosis1.46405363
41MP0002822_catalepsy1.44406486
42MP0002837_dystrophic_cardiac_calcinosis1.44337813
43MP0003191_abnormal_cellular_cholesterol1.44178516
44MP0003868_abnormal_feces_composition1.40365766
45MP0005187_abnormal_penis_morphology1.39102088
46MP0003635_abnormal_synaptic_transmissio1.39084630
47MP0008877_abnormal_DNA_methylation1.38807696
48MP0006276_abnormal_autonomic_nervous1.38418056
49MP0001485_abnormal_pinna_reflex1.37679123
50MP0000609_abnormal_liver_physiology1.37394642
51MP0002736_abnormal_nociception_after1.36139744
52MP0010234_abnormal_vibrissa_follicle1.33556311
53MP0004270_analgesia1.32867348
54MP0002938_white_spotting1.32853546
55MP0000631_abnormal_neuroendocrine_gland1.32604378
56MP0004147_increased_porphyrin_level1.32216427
57MP0004142_abnormal_muscle_tone1.31623817
58MP0008057_abnormal_DNA_replication1.31005223
59MP0003937_abnormal_limbs/digits/tail_de1.28487405
60MP0009643_abnormal_urine_homeostasis1.27966373
61MP0004885_abnormal_endolymph1.27535096
62MP0000778_abnormal_nervous_system1.27095286
63MP0003705_abnormal_hypodermis_morpholog1.24242294
64MP0003787_abnormal_imprinting1.23609779
65MP0000013_abnormal_adipose_tissue1.22395014
66MP0005319_abnormal_enzyme/_coenzyme1.22302173
67MP0003890_abnormal_embryonic-extraembry1.20841807
68MP0005535_abnormal_body_temperature1.18827887
69MP0009745_abnormal_behavioral_response1.17992436
70MP0003283_abnormal_digestive_organ1.17647215
71MP0002064_seizures1.17027843
72MP0002557_abnormal_social/conspecific_i1.15696791
73MP0005174_abnormal_tail_pigmentation1.12938001
74MP0004134_abnormal_chest_morphology1.12457866
75MP0002735_abnormal_chemical_nociception1.09869174
76MP0003633_abnormal_nervous_system1.09833997
77MP0002063_abnormal_learning/memory/cond1.07696226
78MP0002009_preneoplasia1.07612156
79MP0002909_abnormal_adrenal_gland1.07244030
80MP0000647_abnormal_sebaceous_gland1.04524116
81MP0002184_abnormal_innervation1.03971889
82MP0000920_abnormal_myelination1.03465374
83MP0005645_abnormal_hypothalamus_physiol1.03169879
84MP0002160_abnormal_reproductive_system1.03028942
85MP0001756_abnormal_urination1.01917191
86MP0008775_abnormal_heart_ventricle1.01417482
87MP0003119_abnormal_digestive_system1.01218576
88MP0003880_abnormal_central_pattern0.99134737
89MP0002234_abnormal_pharynx_morphology0.98855863
90MP0004484_altered_response_of0.98642298
91MP0004085_abnormal_heartbeat0.98157888
92MP0002078_abnormal_glucose_homeostasis0.97568906
93MP0005670_abnormal_white_adipose0.97458937
94MP0002067_abnormal_sensory_capabilities0.97458765
95MP0009046_muscle_twitch0.96799262
96MP0009384_cardiac_valve_regurgitation0.96172043
97MP0004084_abnormal_cardiac_muscle0.95982652
98MP0008438_abnormal_cutaneous_collagen0.95157698
99MP0001765_abnormal_ion_homeostasis0.93908429
100MP0001502_abnormal_circadian_rhythm0.93518117
101MP0000538_abnormal_urinary_bladder0.93075814
102MP0001486_abnormal_startle_reflex0.93040822
103MP0003137_abnormal_impulse_conducting0.92167305
104MP0008872_abnormal_physiological_respon0.90818655
105MP0005666_abnormal_adipose_tissue0.90817241
106MP0002971_abnormal_brown_adipose0.90384132
107MP0004133_heterotaxia0.89391959
108MP0002090_abnormal_vision0.88915764
109MP0005636_abnormal_mineral_homeostasis0.86769407
110MP0005195_abnormal_posterior_eye0.85807395
111MP0001970_abnormal_pain_threshold0.85760597
112MP0002272_abnormal_nervous_system0.84905744
113MP0000026_abnormal_inner_ear0.84172344
114MP0003300_gastrointestinal_ulcer0.83381395
115MP0003075_altered_response_to0.82801823
116MP0003631_nervous_system_phenotype0.82229081
117MP0000955_abnormal_spinal_cord0.82126143
118MP0005248_abnormal_Harderian_gland0.81772576
119MP0003011_delayed_dark_adaptation0.81737474
120MP0001661_extended_life_span0.81635605
121MP0002572_abnormal_emotion/affect_behav0.81332888
122MP0005167_abnormal_blood-brain_barrier0.81081314
123MP0002233_abnormal_nose_morphology0.80630144
124MP0005084_abnormal_gallbladder_morpholo0.80138700
125MP0001764_abnormal_homeostasis0.79974891
126MP0003950_abnormal_plasma_membrane0.79434108
127MP0008874_decreased_physiological_sensi0.79341028
128MP0000230_abnormal_systemic_arterial0.78837022
129MP0001299_abnormal_eye_distance/0.78351840
130MP0002752_abnormal_somatic_nervous0.78141405
131MP0003122_maternal_imprinting0.78043996
132MP0005423_abnormal_somatic_nervous0.77685096
133MP0001177_atelectasis0.76006653
134MP0002254_reproductive_system_inflammat0.75016641
135MP0008961_abnormal_basal_metabolism0.74559722
136MP0005058_abnormal_lysosome_morphology0.73581077
137MP0004858_abnormal_nervous_system0.73208349
138MP0002876_abnormal_thyroid_physiology0.72845367
139MP0001440_abnormal_grooming_behavior0.70990984
140MP0005334_abnormal_fat_pad0.70948159
141MP0002168_other_aberrant_phenotype0.69881560
142MP0001501_abnormal_sleep_pattern0.69792222
143MP0005375_adipose_tissue_phenotype0.69050948
144MP0010368_abnormal_lymphatic_system0.68959636
145MP0000003_abnormal_adipose_tissue0.65846745
146MP0000747_muscle_weakness0.65091330
147MP0005647_abnormal_sex_gland0.64646378
148MP0004924_abnormal_behavior0.63718654
149MP0005386_behavior/neurological_phenoty0.63718654
150MP0002734_abnormal_mechanical_nocicepti0.62660164
151MP0003632_abnormal_nervous_system0.62534702
152MP0002295_abnormal_pulmonary_circulatio0.62061432
153MP0004036_abnormal_muscle_relaxation0.60810076
154MP0009642_abnormal_blood_homeostasis0.60615982
155MP0004185_abnormal_adipocyte_glucose0.59686491
156MP0000639_abnormal_adrenal_gland0.59560506
157MP0005448_abnormal_energy_balance0.59497116
158MP0008569_lethality_at_weaning0.58910602
159MP0001968_abnormal_touch/_nociception0.58850902
160MP0003634_abnormal_glial_cell0.58300364
161MP0005646_abnormal_pituitary_gland0.57685935
162MP0002069_abnormal_eating/drinking_beha0.56989423
163MP0003656_abnormal_erythrocyte_physiolo0.56887288
164MP0002928_abnormal_bile_duct0.56867077

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.14250193
2Abnormality of aromatic amino acid family metabolism (HP:0004338)5.01564071
3Intrahepatic cholestasis (HP:0001406)4.81243069
4Xanthomatosis (HP:0000991)4.70540915
5Pancreatic cysts (HP:0001737)4.19694188
6Hyperlipoproteinemia (HP:0010980)4.07877720
7Ketosis (HP:0001946)3.99916412
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.95777197
9Pancreatic fibrosis (HP:0100732)3.79957243
10True hermaphroditism (HP:0010459)3.73947225
11Ketoacidosis (HP:0001993)3.71104604
12Prolonged partial thromboplastin time (HP:0003645)3.65573895
13Complement deficiency (HP:0004431)3.59588096
14Hyperammonemia (HP:0001987)3.53879006
15Hypobetalipoproteinemia (HP:0003563)3.52641253
16Abnormality of glutamine family amino acid metabolism (HP:0010902)3.43846936
17Abnormality of serine family amino acid metabolism (HP:0010894)3.40102769
18Abnormality of glycine metabolism (HP:0010895)3.40102769
19Hyperglycinuria (HP:0003108)3.37260939
20Hyperglycinemia (HP:0002154)3.37008140
21Hypoglycemic coma (HP:0001325)3.35023385
22Medial flaring of the eyebrow (HP:0010747)3.34911023
23Abnormality of the renal cortex (HP:0011035)3.34416232
24Gaze-evoked nystagmus (HP:0000640)3.25418306
25Aplasia/Hypoplasia of the tibia (HP:0005772)3.24481002
26Genetic anticipation (HP:0003743)3.24119633
27Gout (HP:0001997)3.23091602
28Epidermoid cyst (HP:0200040)3.19406905
29Hypoalphalipoproteinemia (HP:0003233)3.17892977
30Hypolipoproteinemia (HP:0010981)3.09405085
31Abnormality of midbrain morphology (HP:0002418)3.06076864
32Molar tooth sign on MRI (HP:0002419)3.06076864
33Nephronophthisis (HP:0000090)3.03834145
34Abnormality of the common coagulation pathway (HP:0010990)2.96584716
35Abnormality of the renal medulla (HP:0100957)2.95845733
36Abnormality of aspartate family amino acid metabolism (HP:0010899)2.93253841
37Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.92175686
38Gait imbalance (HP:0002141)2.90498652
39Genital tract atresia (HP:0001827)2.83621173
40Congenital primary aphakia (HP:0007707)2.83596222
41Abnormality of sulfur amino acid metabolism (HP:0004339)2.83015956
42Abnormality of fatty-acid metabolism (HP:0004359)2.82589187
43Febrile seizures (HP:0002373)2.80767372
44Renal cortical cysts (HP:0000803)2.76130423
45Progressive cerebellar ataxia (HP:0002073)2.74868980
46Vaginal atresia (HP:0000148)2.72018924
47Neurofibrillary tangles (HP:0002185)2.70752263
48Cystic liver disease (HP:0006706)2.66764003
49Tubular atrophy (HP:0000092)2.65415846
50Abnormality of purine metabolism (HP:0004352)2.60893704
51Increased corneal curvature (HP:0100692)2.60490388
52Keratoconus (HP:0000563)2.60490388
53Fat malabsorption (HP:0002630)2.60082088
54Skin nodule (HP:0200036)2.59051108
55Chronic hepatic failure (HP:0100626)2.57070774
56Large for gestational age (HP:0001520)2.54777606
57Nephrogenic diabetes insipidus (HP:0009806)2.54084287
58Delayed CNS myelination (HP:0002188)2.50456621
59Abnormality of methionine metabolism (HP:0010901)2.48828458
60Joint hemorrhage (HP:0005261)2.48636745
61Hypokalemic alkalosis (HP:0001949)2.46965252
62Cerebral inclusion bodies (HP:0100314)2.46611439
63Increased circulating renin level (HP:0000848)2.44354038
64Fair hair (HP:0002286)2.42520192
65Hemiparesis (HP:0001269)2.42514617
66Hypercholesterolemia (HP:0003124)2.40276496
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.37018998
68Abnormality of the intrinsic pathway (HP:0010989)2.36866059
69Alkalosis (HP:0001948)2.35590789
70Conjugated hyperbilirubinemia (HP:0002908)2.35294694
71Short tibia (HP:0005736)2.34117483
72Abolished electroretinogram (ERG) (HP:0000550)2.32948542
73Abnormality of the ischium (HP:0003174)2.31864386
74Abnormality of complement system (HP:0005339)2.30205880
75Mitral stenosis (HP:0001718)2.30198037
76Chorioretinal atrophy (HP:0000533)2.30156734
77Sensorimotor neuropathy (HP:0007141)2.29629694
78Congenital sensorineural hearing impairment (HP:0008527)2.29278749
79Hyperventilation (HP:0002883)2.29085027
80Hypothermia (HP:0002045)2.27118035
81Hypoglycemic seizures (HP:0002173)2.26921192
82Status epilepticus (HP:0002133)2.24846644
83Metabolic alkalosis (HP:0200114)2.22186639
84Furrowed tongue (HP:0000221)2.20309800
85Congenital stationary night blindness (HP:0007642)2.18902982
86Decreased circulating renin level (HP:0003351)2.18423679
87Poor coordination (HP:0002370)2.18119784
88Hyperuricemia (HP:0002149)2.18049308
89Increased purine levels (HP:0004368)2.18049308
90Type II lissencephaly (HP:0007260)2.16679218
91Focal motor seizures (HP:0011153)2.14645537
92Metabolic acidosis (HP:0001942)2.12846103
93Aplasia/Hypoplasia of the tongue (HP:0010295)2.10435055
94Intention tremor (HP:0002080)2.10117722
95Hepatocellular carcinoma (HP:0001402)2.09996782
96Vascular calcification (HP:0004934)2.09560548
97Attenuation of retinal blood vessels (HP:0007843)2.09329405
98Hyperbilirubinemia (HP:0002904)2.08464472
99Abnormality of the nasal septum (HP:0000419)2.08335794
100Turricephaly (HP:0000262)2.08159547
101Postaxial foot polydactyly (HP:0001830)2.07871810
102Broad-based gait (HP:0002136)2.07841177
103Cerebellar dysplasia (HP:0007033)2.07439361
104Abnormality of nucleobase metabolism (HP:0010932)2.06256432
105Preaxial foot polydactyly (HP:0001841)2.06127699
106Myocardial infarction (HP:0001658)2.05808047
107Male pseudohermaphroditism (HP:0000037)2.05597890
108Hyperinsulinemic hypoglycemia (HP:0000825)2.05570521
109Drooling (HP:0002307)2.05004601
110Cardiovascular calcification (HP:0011915)2.04038288
111Abnormality of proline metabolism (HP:0010907)2.03467743
112Hydroxyprolinuria (HP:0003080)2.03467743
113Action tremor (HP:0002345)2.03248803
114Progressive inability to walk (HP:0002505)2.03136351
115Neonatal onset (HP:0003623)2.02620739
116Abnormality of serum amino acid levels (HP:0003112)2.01800768
117Abnormal drinking behavior (HP:0030082)2.00814473
118Polydipsia (HP:0001959)2.00814473
119Cutaneous finger syndactyly (HP:0010554)1.99909588
120Postaxial hand polydactyly (HP:0001162)1.99296231
121Myokymia (HP:0002411)1.97986820
122Short foot (HP:0001773)1.97653815
123Protruding tongue (HP:0010808)1.97213146
124Generalized hypopigmentation of hair (HP:0011358)1.95649751
125Hypoplastic ischia (HP:0003175)1.95023347
126Short hallux (HP:0010109)1.94799629
127Absent speech (HP:0001344)1.94606370
128Dicarboxylic aciduria (HP:0003215)1.93784772
129Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93784772
130Inability to walk (HP:0002540)1.93746380
131Spastic diplegia (HP:0001264)1.93652074
132Irritability (HP:0000737)1.92945895
133Congenital hepatic fibrosis (HP:0002612)1.90051708
134Aplasia/Hypoplasia of the hallux (HP:0008362)1.90015896
135Abnormality of the Achilles tendon (HP:0005109)1.89374807
136Abnormal gallbladder morphology (HP:0012437)1.88513754
137Dialeptic seizures (HP:0011146)1.85467610
138Hyperaldosteronism (HP:0000859)1.83967530
139Torticollis (HP:0000473)1.83514905
140Cholelithiasis (HP:0001081)1.82849219
141Abnormality of alanine metabolism (HP:0010916)1.81717546
142Hyperalaninemia (HP:0003348)1.81717546
143Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.81717546
144Generalized aminoaciduria (HP:0002909)1.80867678
145Amyloidosis (HP:0011034)1.79781100
146Specific learning disability (HP:0001328)1.77785662
147Abnormality of renin-angiotensin system (HP:0000847)1.77108098
148Confusion (HP:0001289)1.76949387
149Steatorrhea (HP:0002570)1.76351369
150Proximal tubulopathy (HP:0000114)1.75493312
151Abnormal ciliary motility (HP:0012262)1.75095546
152Hypoplastic labia majora (HP:0000059)1.74787984
153Abnormality of secondary sexual hair (HP:0009888)1.74565014
154Abnormality of the axillary hair (HP:0100134)1.74565014
155Thyroid-stimulating hormone excess (HP:0002925)1.74182564
156Excessive salivation (HP:0003781)1.74164757
157Lethargy (HP:0001254)1.74161172
158Vomiting (HP:0002013)1.73269387
159Spontaneous abortion (HP:0005268)1.73154591
160Back pain (HP:0003418)1.73137576
161Termporal pattern (HP:0011008)1.72731841
162Insidious onset (HP:0003587)1.72731841
163Widely spaced teeth (HP:0000687)1.72078908
164Scanning speech (HP:0002168)1.71816491
165Enlarged kidneys (HP:0000105)1.71573381
166Abnormal gallbladder physiology (HP:0012438)1.70823095
167Cholecystitis (HP:0001082)1.70823095
168Focal seizures (HP:0007359)1.70791729
169Blue irides (HP:0000635)1.70276891
170Myoglobinuria (HP:0002913)1.69990793
171Hyperglycemia (HP:0003074)1.69555820
172Craniofacial dystonia (HP:0012179)1.69209721
173Sclerocornea (HP:0000647)1.68745318
174Lymphangioma (HP:0100764)1.68679019
175Abnormal biliary tract morphology (HP:0012440)1.68546778
176Abnormality of macular pigmentation (HP:0008002)1.67894088
177Long nose (HP:0003189)1.67708316
178Pheochromocytoma (HP:0002666)1.66889775
179Hyperactive renin-angiotensin system (HP:0000841)1.66123783
180Focal dystonia (HP:0004373)1.65536045
181Congenital, generalized hypertrichosis (HP:0004540)1.65479462
182Aplasia/Hypoplasia of the fibula (HP:0006492)1.64638268
183Cerebral hemorrhage (HP:0001342)1.64459736
184Atonic seizures (HP:0010819)1.63822210
185Hypokalemia (HP:0002900)1.62185580
186Abnormality of the labia majora (HP:0012881)1.61228611
187Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.61168263
188Polyuria (HP:0000103)1.60277565
189Absent/shortened dynein arms (HP:0200106)1.59205196
190Dynein arm defect of respiratory motile cilia (HP:0012255)1.59205196
191Clumsiness (HP:0002312)1.58948743
192Calf muscle hypertrophy (HP:0008981)1.58826577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA42.66368802
2ACVR1B2.63809064
3CASK2.59192768
4BMPR1B2.44661022
5BCKDK2.44493999
6OXSR12.29996180
7FRK2.25097183
8NTRK32.24487316
9SIK12.23887989
10WNK42.23170948
11FGFR22.16892615
12STK38L1.92374795
13INSRR1.91860025
14ERBB31.90206433
15TRIB31.89817863
16STK391.88766042
17MAP2K41.83810175
18NTRK11.82526214
19AKT31.79721450
20MAP3K91.78551582
21GRK11.77968656
22DAPK21.77576529
23ADRBK21.75318496
24WNK31.74526526
25KSR21.67907389
26MAP3K41.67368573
27MAP4K21.66710785
28TNIK1.63754385
29MAPK131.55255093
30PAK31.45830419
31PRKD31.45817258
32BCR1.41120493
33MAP3K21.40231384
34PAK61.36409679
35OBSCN1.34760566
36FGFR41.34517278
37CAMKK11.34104571
38SGK2231.33833084
39SGK4941.33833084
40PKN21.28727216
41PRKCH1.28381655
42ERN11.28314624
43PDGFRA1.23604294
44MAP3K131.22572727
45MAP3K71.21166146
46SGK31.20105381
47PLK21.15991831
48WNK11.15954020
49RET1.14603140
50NUAK11.13199510
51MINK11.11472012
52CAMK1G1.10930529
53RIPK11.10494723
54ERBB41.10070711
55LMTK21.08854939
56FER1.07507172
57PHKG21.05532236
58PHKG11.05532236
59NLK1.05210382
60STK381.02557770
61PTK61.01112850
62PINK10.99120046
63SGK20.97568771
64BRSK20.96949870
65MST1R0.95938041
66ZAK0.95325476
67MKNK20.94907564
68STK30.92932480
69PDPK10.92071209
70LATS10.90469937
71MARK10.89802530
72PDK40.89706072
73PDK30.89706072
74CDK50.88670280
75EPHA30.88128056
76CAMK1D0.87642628
77EPHB10.87245379
78TGFBR10.87184316
79MET0.85034069
80DDR20.84979302
81CAMKK20.84515466
82CSNK1G10.84327186
83TRIM280.83770428
84CSNK1A1L0.82045901
85TRPM70.80358151
86STK240.79849504
87PDK10.77137429
88NTRK20.76084746
89ADRBK10.75059151
90JAK10.73082405
91PRKCG0.72565554
92PTK20.72178305
93PTK2B0.71242696
94MAP2K10.70621148
95MAP2K70.69996430
96CAMK2A0.69783093
97FLT30.69531047
98PRKCZ0.69325275
99CAMK2G0.68746992
100EIF2AK30.68340895
101KSR10.68095690
102SGK10.67311163
103PRKAA20.66926509
104TTN0.66579542
105CAMK2B0.65250361
106TYRO30.63789951
107CSNK1G20.63782311
108STK110.63303886
109JAK20.63296485
110MST40.61760697
111PRKD10.61475401
112MAPK120.60076898
113TXK0.59349499
114PRKAA10.58268855
115ERBB20.58246397
116PNCK0.55811676
117MUSK0.55655196
118BMX0.55379064
119PDK20.54989752
120PRKCE0.54860395
121PRKACG0.54804656
122TAOK30.54762282
123PDGFRB0.54139933
124FGFR30.53714888
125CSNK1G30.53434851
126CAMK2D0.52456213
127PKN10.51766021
128PRKCQ0.51279682
129MAPK110.51195426
130MYLK0.50525335
131MKNK10.50481713
132NEK90.50230587
133MAP3K10.50162252
134TIE10.49938602
135GSK3A0.48846746
136PIK3CG0.45927394
137FYN0.45363290
138PIK3CA0.44453489
139RPS6KA30.43933590
140FGFR10.43829879
141DYRK1A0.39117902
142PRKACA0.38376692
143NEK60.37113268
144CSNK1D0.35915883
145CSNK1A10.34829938
146RPS6KB10.34673001
147BMPR20.33511926

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.10472181
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.27041083
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.84972428
4Arginine biosynthesis_Homo sapiens_hsa002202.53448918
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.44576928
6Butanoate metabolism_Homo sapiens_hsa006502.42931801
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.41002533
8Fatty acid degradation_Homo sapiens_hsa000712.34564763
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.33615328
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16399024
11Propanoate metabolism_Homo sapiens_hsa006402.16386327
12Phototransduction_Homo sapiens_hsa047442.14812238
13Tryptophan metabolism_Homo sapiens_hsa003802.12203327
14Fatty acid metabolism_Homo sapiens_hsa012121.92887189
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.87676566
16PPAR signaling pathway_Homo sapiens_hsa033201.79047633
17Linoleic acid metabolism_Homo sapiens_hsa005911.78305395
18Complement and coagulation cascades_Homo sapiens_hsa046101.77630564
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.77415542
20Bile secretion_Homo sapiens_hsa049761.74959857
21Peroxisome_Homo sapiens_hsa041461.66720446
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.65693477
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64745705
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59245650
25Circadian rhythm_Homo sapiens_hsa047101.55791108
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.52962995
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.48757336
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48026400
29Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.46277287
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45852282
31Ether lipid metabolism_Homo sapiens_hsa005651.41765699
32beta-Alanine metabolism_Homo sapiens_hsa004101.40809600
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40806475
34Sulfur metabolism_Homo sapiens_hsa009201.40740358
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.38141691
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35681366
37Pyruvate metabolism_Homo sapiens_hsa006201.32246514
38Histidine metabolism_Homo sapiens_hsa003401.23977976
39Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22082279
40Serotonergic synapse_Homo sapiens_hsa047261.18017595
41Chemical carcinogenesis_Homo sapiens_hsa052041.17828209
42Steroid hormone biosynthesis_Homo sapiens_hsa001401.16748498
43Fatty acid elongation_Homo sapiens_hsa000621.16462462
44Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.15597119
45Protein export_Homo sapiens_hsa030601.13352146
46Dorso-ventral axis formation_Homo sapiens_hsa043201.12835167
47Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.10440717
48Caffeine metabolism_Homo sapiens_hsa002321.04077577
49Phenylalanine metabolism_Homo sapiens_hsa003601.03618091
50Starch and sucrose metabolism_Homo sapiens_hsa005001.01902819
51Ovarian steroidogenesis_Homo sapiens_hsa049130.98920927
52Regulation of autophagy_Homo sapiens_hsa041400.97693498
53Long-term depression_Homo sapiens_hsa047300.97286456
54Mineral absorption_Homo sapiens_hsa049780.96987172
55ABC transporters_Homo sapiens_hsa020100.96175958
56Carbon metabolism_Homo sapiens_hsa012000.95680986
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.95376745
58Retinol metabolism_Homo sapiens_hsa008300.94575674
59Tyrosine metabolism_Homo sapiens_hsa003500.91402217
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91293802
61Fatty acid biosynthesis_Homo sapiens_hsa000610.91082753
62TGF-beta signaling pathway_Homo sapiens_hsa043500.90360862
63Vascular smooth muscle contraction_Homo sapiens_hsa042700.83812580
64GABAergic synapse_Homo sapiens_hsa047270.83319864
65Staphylococcus aureus infection_Homo sapiens_hsa051500.82688068
66Hedgehog signaling pathway_Homo sapiens_hsa043400.80793198
67Steroid biosynthesis_Homo sapiens_hsa001000.80527654
68Glycerolipid metabolism_Homo sapiens_hsa005610.79704362
69Selenocompound metabolism_Homo sapiens_hsa004500.77339560
70Hippo signaling pathway_Homo sapiens_hsa043900.75454545
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74180633
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73916733
73Protein digestion and absorption_Homo sapiens_hsa049740.72858826
74Biosynthesis of amino acids_Homo sapiens_hsa012300.72789744
75Sphingolipid metabolism_Homo sapiens_hsa006000.72364372
76Fat digestion and absorption_Homo sapiens_hsa049750.71912859
77Maturity onset diabetes of the young_Homo sapiens_hsa049500.71375798
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70187688
79Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68680377
80Axon guidance_Homo sapiens_hsa043600.67888909
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.67032145
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.65297508
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65159456
84Lysine degradation_Homo sapiens_hsa003100.64774846
85Arginine and proline metabolism_Homo sapiens_hsa003300.64674371
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.63430077
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61590325
88Basal cell carcinoma_Homo sapiens_hsa052170.61083199
89Nicotine addiction_Homo sapiens_hsa050330.59998070
90Vitamin digestion and absorption_Homo sapiens_hsa049770.59711340
91Arachidonic acid metabolism_Homo sapiens_hsa005900.59516580
92Insulin secretion_Homo sapiens_hsa049110.57764558
93Glutamatergic synapse_Homo sapiens_hsa047240.56463425
94Basal transcription factors_Homo sapiens_hsa030220.54348202
95Gastric acid secretion_Homo sapiens_hsa049710.53962562
96Cyanoamino acid metabolism_Homo sapiens_hsa004600.53959888
97Salivary secretion_Homo sapiens_hsa049700.53769766
98Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.53569439
99Circadian entrainment_Homo sapiens_hsa047130.52833069
100ECM-receptor interaction_Homo sapiens_hsa045120.52826114
101Synaptic vesicle cycle_Homo sapiens_hsa047210.52376894
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51116295
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.50943230
104Dilated cardiomyopathy_Homo sapiens_hsa054140.49218407
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.48796098
106Glucagon signaling pathway_Homo sapiens_hsa049220.48663959
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.48322268
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.47900339
109Insulin resistance_Homo sapiens_hsa049310.46608389
110Long-term potentiation_Homo sapiens_hsa047200.45637123
111Renin secretion_Homo sapiens_hsa049240.45435158
112Morphine addiction_Homo sapiens_hsa050320.45177446
113Tight junction_Homo sapiens_hsa045300.44370078
114Thyroid hormone synthesis_Homo sapiens_hsa049180.42917717
115Prion diseases_Homo sapiens_hsa050200.42899942
116Amphetamine addiction_Homo sapiens_hsa050310.42071215
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41526121
118Type II diabetes mellitus_Homo sapiens_hsa049300.40353442
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.40082893
120Olfactory transduction_Homo sapiens_hsa047400.38984727
121Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.38745528
122Dopaminergic synapse_Homo sapiens_hsa047280.33156946
123Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.33020371
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32700253
125Cocaine addiction_Homo sapiens_hsa050300.31318337
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31240538
127Vitamin B6 metabolism_Homo sapiens_hsa007500.28441056
128Cholinergic synapse_Homo sapiens_hsa047250.28295657
129Folate biosynthesis_Homo sapiens_hsa007900.27341527
130AMPK signaling pathway_Homo sapiens_hsa041520.26856466
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.26325220
132cAMP signaling pathway_Homo sapiens_hsa040240.24718078
133Pancreatic secretion_Homo sapiens_hsa049720.24638806
134Calcium signaling pathway_Homo sapiens_hsa040200.21232055
135Insulin signaling pathway_Homo sapiens_hsa049100.21099337
136Taste transduction_Homo sapiens_hsa047420.20730335
137Oxytocin signaling pathway_Homo sapiens_hsa049210.19491811

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