TMEM106C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)7.08163354
2GDP-mannose metabolic process (GO:0019673)5.22797398
3DNA strand elongation involved in DNA replication (GO:0006271)4.89847370
4DNA strand elongation (GO:0022616)4.74286876
5DNA deamination (GO:0045006)4.65601776
6histone H4-K12 acetylation (GO:0043983)4.49320548
7negative regulation of cell cycle G2/M phase transition (GO:1902750)4.45146641
8maintenance of protein location in nucleus (GO:0051457)4.41693587
9pteridine-containing compound biosynthetic process (GO:0042559)4.38334502
10regulation of nuclear cell cycle DNA replication (GO:0033262)4.37300109
11cytidine deamination (GO:0009972)4.37101706
12cytidine metabolic process (GO:0046087)4.37101706
13cytidine catabolic process (GO:0006216)4.37101706
14regulation of mammary gland epithelial cell proliferation (GO:0033599)4.33929400
15rRNA transcription (GO:0009303)4.31046238
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.28507227
17regulation of cilium movement (GO:0003352)4.21517824
18telomere maintenance via recombination (GO:0000722)4.19341760
19cullin deneddylation (GO:0010388)4.17386170
20rRNA methylation (GO:0031167)4.15531172
21protein deneddylation (GO:0000338)4.08898924
22proteasome assembly (GO:0043248)4.04607178
23somite rostral/caudal axis specification (GO:0032525)4.04581208
24regulation of apoptotic process involved in morphogenesis (GO:1902337)4.03745462
25nucleobase-containing small molecule interconversion (GO:0015949)3.99225005
26negative regulation of epidermis development (GO:0045683)3.96537932
27mitotic recombination (GO:0006312)3.93847794
28deoxyribonucleotide biosynthetic process (GO:0009263)3.91760681
29mitotic chromosome condensation (GO:0007076)3.90622981
30sister chromatid segregation (GO:0000819)3.89021710
31establishment of integrated proviral latency (GO:0075713)3.86199799
32maintenance of protein localization in organelle (GO:0072595)3.85408523
33COPI coating of Golgi vesicle (GO:0048205)3.83125843
34Golgi transport vesicle coating (GO:0048200)3.83125843
35histone H4-K5 acetylation (GO:0043981)3.81306298
36histone H4-K8 acetylation (GO:0043982)3.81306298
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.80569862
38negative regulation of telomerase activity (GO:0051974)3.80226290
39rRNA modification (GO:0000154)3.78892908
40CENP-A containing nucleosome assembly (GO:0034080)3.77893454
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.76501535
42protein localization to kinetochore (GO:0034501)3.74782612
43negative regulation of phagocytosis (GO:0050765)3.73514492
44quinone metabolic process (GO:1901661)3.71698598
45pyrimidine ribonucleoside catabolic process (GO:0046133)3.71126118
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.68655661
47negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66695863
48chromatin remodeling at centromere (GO:0031055)3.61527949
49muscle organ morphogenesis (GO:0048644)3.60381600
50regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60279009
51negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.58642280
52signal peptide processing (GO:0006465)3.57653541
53coenzyme catabolic process (GO:0009109)3.55541829
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.55238006
55hormone catabolic process (GO:0042447)3.53702171
56proline biosynthetic process (GO:0006561)3.51498875
57positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.49901128
58valine metabolic process (GO:0006573)3.49763917
59DNA replication checkpoint (GO:0000076)3.47671591
60formation of translation preinitiation complex (GO:0001731)3.47223278
61mitotic metaphase plate congression (GO:0007080)3.45886127
62regulation of response to osmotic stress (GO:0047484)3.44340663
63negative regulation of telomere maintenance (GO:0032205)3.40563486
64pseudouridine synthesis (GO:0001522)3.39573838
65protein maturation by protein folding (GO:0022417)3.39337912
66regulation of mitochondrial translation (GO:0070129)3.38505747
67negative regulation of ligase activity (GO:0051352)3.38118506
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.38118506
69ribosomal small subunit assembly (GO:0000028)3.33590316
70negative regulation of epidermal cell differentiation (GO:0045605)3.31355442
71DNA ligation (GO:0006266)3.30576275
72regulation of telomere maintenance via telomerase (GO:0032210)3.23011992
73regulation of cellular amino acid metabolic process (GO:0006521)3.21926521
74folic acid-containing compound biosynthetic process (GO:0009396)3.20021873
75primitive streak formation (GO:0090009)3.19568635
76nucleoside transmembrane transport (GO:1901642)3.19231382
77purine nucleobase biosynthetic process (GO:0009113)3.18800463
78regulation of mitotic spindle organization (GO:0060236)3.17959203
79response to dietary excess (GO:0002021)3.17956262
80transcription from mitochondrial promoter (GO:0006390)3.17152074
81metaphase plate congression (GO:0051310)3.15228348
82positive regulation of DNA-dependent DNA replication (GO:2000105)3.14845274
83interferon-gamma production (GO:0032609)3.13564971
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10238495
85regulation of spindle organization (GO:0090224)3.09871457
86positive regulation of protein deacetylation (GO:0090312)3.09194850
87telomere maintenance via telomere lengthening (GO:0010833)3.06538206
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05707274
89signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05707274
90ATP synthesis coupled proton transport (GO:0015986)3.05676536
91energy coupled proton transport, down electrochemical gradient (GO:0015985)3.05676536
92establishment of viral latency (GO:0019043)3.05407319
93ribosome biogenesis (GO:0042254)3.04847714
94protein K6-linked ubiquitination (GO:0085020)3.04798648
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.04763255
96DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04737789
97kinetochore organization (GO:0051383)3.04675873
98signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.04457771
99signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.04457771
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.04457771
101deoxyribose phosphate biosynthetic process (GO:0046385)3.03461410
1022-deoxyribonucleotide biosynthetic process (GO:0009265)3.03461410
103regulation of translation in response to stress (GO:0043555)3.02747484
104signal transduction involved in DNA integrity checkpoint (GO:0072401)3.02169599
105signal transduction involved in DNA damage checkpoint (GO:0072422)3.02169599
106mitochondrial DNA replication (GO:0006264)3.01963829
107glycoside metabolic process (GO:0016137)3.01202439
108maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.00980928
109regulation of sister chromatid cohesion (GO:0007063)3.00802577
110tricarboxylic acid cycle (GO:0006099)3.00221021
111L-serine metabolic process (GO:0006563)2.97918250
112cellular modified amino acid catabolic process (GO:0042219)2.96637420
113protein retention in ER lumen (GO:0006621)2.96351339
114ribosome assembly (GO:0042255)2.95375032
115signal transduction involved in cell cycle checkpoint (GO:0072395)2.95252424
116guanosine-containing compound biosynthetic process (GO:1901070)2.92676888
117folic acid metabolic process (GO:0046655)2.92553720
118transcription-coupled nucleotide-excision repair (GO:0006283)2.91671499
119GMP metabolic process (GO:0046037)2.90756347
120non-recombinational repair (GO:0000726)2.89380145
121double-strand break repair via nonhomologous end joining (GO:0006303)2.89380145
122nucleobase biosynthetic process (GO:0046112)2.88507292
123positive regulation of ligase activity (GO:0051351)2.88085831
124establishment of protein localization to mitochondrial membrane (GO:0090151)2.88052644
125cell cycle G1/S phase transition (GO:0044843)2.87824098
126G1/S transition of mitotic cell cycle (GO:0000082)2.87824098
127protein neddylation (GO:0045116)2.85958511
128DNA replication initiation (GO:0006270)2.85681061
129regulation of ubiquitin-protein transferase activity (GO:0051438)2.85272406
130regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84925178
131phenol-containing compound catabolic process (GO:0019336)2.83829528
132DNA replication-independent nucleosome assembly (GO:0006336)2.80866235
133DNA replication-independent nucleosome organization (GO:0034724)2.80866235
134pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78310734
135histone exchange (GO:0043486)2.76350100
136respiratory electron transport chain (GO:0022904)2.74878125
137mitotic sister chromatid segregation (GO:0000070)2.74336696
138thyroid hormone generation (GO:0006590)2.74234671
139NADH metabolic process (GO:0006734)2.73955965
140heparin biosynthetic process (GO:0030210)2.73331224
141heparin metabolic process (GO:0030202)2.73331224
142protein localization to cilium (GO:0061512)2.73006420
143regulation of ligase activity (GO:0051340)2.71999590
144L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.71589819
145chromosome condensation (GO:0030261)2.71311657
146electron transport chain (GO:0022900)2.71047882
147establishment of chromosome localization (GO:0051303)2.70982027
148protein polyglutamylation (GO:0018095)2.69932688
149positive regulation of chromosome segregation (GO:0051984)2.69843033
150branched-chain amino acid catabolic process (GO:0009083)2.69409529
151nucleotide-sugar metabolic process (GO:0009225)2.68460646
152tetrahydrofolate metabolic process (GO:0046653)2.68416107
153pteridine-containing compound metabolic process (GO:0042558)2.68237876
154oxidative phosphorylation (GO:0006119)2.68081796
155protein targeting to mitochondrion (GO:0006626)2.66301491
156DNA unwinding involved in DNA replication (GO:0006268)2.65241623
157negative regulation of interleukin-2 production (GO:0032703)2.65210167
158pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65102562
159regulation of microtubule-based movement (GO:0060632)2.64070042
160IMP biosynthetic process (GO:0006188)2.63440635
161pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.62453517
162regulation of MHC class I biosynthetic process (GO:0045343)2.62099584
163serine family amino acid biosynthetic process (GO:0009070)2.61534029
164immunoglobulin mediated immune response (GO:0016064)2.60161759
165protein localization to chromosome, centromeric region (GO:0071459)2.59767515
166melanosome transport (GO:0032402)2.56343371
167regulation of telomerase activity (GO:0051972)2.54317601
168antigen processing and presentation via MHC class Ib (GO:0002475)2.54172207
169megakaryocyte development (GO:0035855)2.53092088
170histone H4-K16 acetylation (GO:0043984)2.51785471
171endosome to pigment granule transport (GO:0043485)2.51444851
172endosome to melanosome transport (GO:0035646)2.51444851
173DNA replication-dependent nucleosome organization (GO:0034723)2.51353260
174DNA replication-dependent nucleosome assembly (GO:0006335)2.51353260
175telomere maintenance via semi-conservative replication (GO:0032201)2.49007799
176mitochondrion distribution (GO:0048311)2.47337336
177cofactor catabolic process (GO:0051187)2.47303643
178cofactor transport (GO:0051181)2.45025300
179biotin metabolic process (GO:0006768)2.44519855
180branched-chain amino acid metabolic process (GO:0009081)2.42813495
181deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.41704348
182sulfur amino acid catabolic process (GO:0000098)2.39415598
183daunorubicin metabolic process (GO:0044597)10.8547478
184polyketide metabolic process (GO:0030638)10.8547478
185doxorubicin metabolic process (GO:0044598)10.8547478

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.41232611
2E2F7_22180533_ChIP-Seq_HELA_Human4.53415512
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.13484439
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.70098835
5AR_21909140_ChIP-Seq_LNCAP_Human3.26824552
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.12038716
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.12038716
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.12038716
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.05161570
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.99850369
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53964163
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.52945740
13SCL_19346495_ChIP-Seq_HPC-7_Human2.41482211
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33401219
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.26571241
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19321969
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.11755876
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.11504442
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.08217322
20PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.08197677
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99767782
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.96271282
23ELK1_19687146_ChIP-ChIP_HELA_Human1.95355707
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.93968415
25MYC_22102868_ChIP-Seq_BL_Human1.93432471
26MYC_19030024_ChIP-ChIP_MESCs_Mouse1.90640785
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90369628
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.82814651
29SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.82778101
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81308957
31FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.81116892
32ZNF263_19887448_ChIP-Seq_K562_Human1.79033092
33POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78628706
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.77845490
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.77683259
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.76502242
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.71721482
38FOXP3_21729870_ChIP-Seq_TREG_Human1.71273200
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.71052505
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.70147523
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.68835446
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.67316456
43TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.66987697
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.63749974
45ETS1_20019798_ChIP-Seq_JURKAT_Human1.62333385
46PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.62102117
47* GABP_19822575_ChIP-Seq_HepG2_Human1.61834001
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.60380150
49* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59971304
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.58915400
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.58914050
52MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57185835
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57094683
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.55612428
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.54208769
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.53126691
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.50882591
58* VDR_23849224_ChIP-Seq_CD4+_Human1.46327138
59* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.44359494
60PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43448593
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.42884994
62* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42285756
63XRN2_22483619_ChIP-Seq_HELA_Human1.39807086
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.37535814
65IRF1_19129219_ChIP-ChIP_H3396_Human1.36083539
66HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.35156454
67POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34285682
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.33115497
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31925220
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.31017626
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30566646
72* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29865918
73SPI1_23547873_ChIP-Seq_NB4_Human1.26189775
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24459451
75SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.24245327
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24101179
77CIITA_25753668_ChIP-Seq_RAJI_Human1.23852670
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23178139
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22997175
80MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22967990
81DCP1A_22483619_ChIP-Seq_HELA_Human1.19082182
82SOX17_20123909_ChIP-Seq_XEN_Mouse1.17670965
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.17541790
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.17305251
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16141302
86NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15469522
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13801812
88GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.12228780
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11571022
90FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.11493668
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.11118051
92* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11008715
93* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.10792876
94NANOG_18555785_ChIP-Seq_MESCs_Mouse1.10462033
95NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09688047
96TFEB_21752829_ChIP-Seq_HELA_Human1.09456971
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.08759935
98CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.07424647
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06873512
100MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04728954
101LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04163618
102HIF1A_21447827_ChIP-Seq_MCF-7_Human1.03076536
103TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02946915
104POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02360957
105BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00484082
106CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.00344543
107TTF2_22483619_ChIP-Seq_HELA_Human1.00024141
108* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99908691
109SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99293372
110* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.99083249
111MYC_18940864_ChIP-ChIP_HL60_Human0.98797828
112FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98633577
113RUNX1_22412390_ChIP-Seq_EML_Mouse0.98446290
114TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98298840
115MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98026415
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.97694016
117STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96877637
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.96503262
119* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96497434
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95639240
121* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.95403668
122EGR1_19374776_ChIP-ChIP_THP-1_Human0.92638861
123* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.92063044
124GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91773544
125VDR_21846776_ChIP-Seq_THP-1_Human0.90969533
126TCF7_22412390_ChIP-Seq_EML_Mouse0.90656848
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90429340
128TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90423062
129CHD1_26751641_Chip-Seq_LNCaP_Human0.89244618
130BCL6_27268052_Chip-Seq_Bcells_Human0.89221393
131KDM5A_27292631_Chip-Seq_BREAST_Human0.88648455
132CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.88064742
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.87222065
134ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84916711
135TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.81104110
136* GATA6_25053715_ChIP-Seq_YYC3_Human0.80340469
137KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79490968
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.79456358
139ELF5_23300383_ChIP-Seq_T47D_Human0.77233495
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.76986120
141CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76717649

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.59800393
2MP0006292_abnormal_olfactory_placode4.18912217
3MP0003111_abnormal_nucleus_morphology3.75406188
4MP0004264_abnormal_extraembryonic_tissu3.69109977
5MP0005075_abnormal_melanosome_morpholog3.56727616
6MP0003183_abnormal_peptide_metabolism3.56432741
7MP0008932_abnormal_embryonic_tissue3.04957028
8MP0010234_abnormal_vibrissa_follicle2.65996754
9MP0000678_abnormal_parathyroid_gland2.62181486
10MP0004957_abnormal_blastocyst_morpholog2.62136942
11MP0002254_reproductive_system_inflammat2.59416550
12MP0005360_urolithiasis2.58018163
13MP0009697_abnormal_copulation2.57801479
14MP0003122_maternal_imprinting2.55227415
15MP0002396_abnormal_hematopoietic_system2.53496350
16MP0010352_gastrointestinal_tract_polyps2.47685365
17MP0008057_abnormal_DNA_replication2.40282919
18MP0005408_hypopigmentation2.36243245
19MP0005394_taste/olfaction_phenotype2.35179403
20MP0005499_abnormal_olfactory_system2.35179403
21MP0002653_abnormal_ependyma_morphology2.14594909
22MP0000537_abnormal_urethra_morphology2.09590532
23MP0003718_maternal_effect2.07795551
24MP0001346_abnormal_lacrimal_gland2.02986581
25MP0001986_abnormal_taste_sensitivity1.95621073
26MP0008007_abnormal_cellular_replicative1.94153912
27MP0003123_paternal_imprinting1.92697818
28MP0002877_abnormal_melanocyte_morpholog1.89053434
29MP0005257_abnormal_intraocular_pressure1.88527339
30MP0003890_abnormal_embryonic-extraembry1.85721698
31MP0004043_abnormal_pH_regulation1.83924632
32MP0003186_abnormal_redox_activity1.74020870
33MP0000490_abnormal_crypts_of1.72065610
34MP0006035_abnormal_mitochondrial_morpho1.71399089
35MP0004147_increased_porphyrin_level1.65195011
36MP0003315_abnormal_perineum_morphology1.64873833
37MP0002938_white_spotting1.63877694
38MP0006036_abnormal_mitochondrial_physio1.61405189
39MP0003172_abnormal_lysosome_physiology1.60467558
40MP0002332_abnormal_exercise_endurance1.57560806
41MP0002132_abnormal_respiratory_system1.55037033
42MP0003121_genomic_imprinting1.53646820
43MP0001730_embryonic_growth_arrest1.49228888
44MP0004858_abnormal_nervous_system1.48008378
45MP0001661_extended_life_span1.47037925
46MP0010030_abnormal_orbit_morphology1.45584942
47MP0005501_abnormal_skin_physiology1.45052476
48MP0005220_abnormal_exocrine_pancreas1.39956444
49MP0005365_abnormal_bile_salt1.38971484
50MP0003077_abnormal_cell_cycle1.37228851
51MP0001835_abnormal_antigen_presentation1.36742859
52MP0002970_abnormal_white_adipose1.33381597
53MP0002909_abnormal_adrenal_gland1.31946792
54MP0001697_abnormal_embryo_size1.30693732
55MP0008961_abnormal_basal_metabolism1.28687527
56MP0001666_abnormal_nutrient_absorption1.27408778
57MP0005671_abnormal_response_to1.26774938
58MP0005171_absent_coat_pigmentation1.25976945
59MP0001545_abnormal_hematopoietic_system1.25814589
60MP0005397_hematopoietic_system_phenotyp1.25814589
61MP0004808_abnormal_hematopoietic_stem1.25493006
62MP0005266_abnormal_metabolism1.22272510
63MP0000372_irregular_coat_pigmentation1.22116837
64MP0009379_abnormal_foot_pigmentation1.21449439
65MP0010307_abnormal_tumor_latency1.19639075
66MP0000358_abnormal_cell_content/1.18987091
67MP0002234_abnormal_pharynx_morphology1.16759464
68MP0006082_CNS_inflammation1.15382824
69MP0008789_abnormal_olfactory_epithelium1.14689614
70MP0003693_abnormal_embryo_hatching1.13462709
71MP0005248_abnormal_Harderian_gland1.12562628
72MP0002080_prenatal_lethality1.12545381
73MP0005332_abnormal_amino_acid1.12279072
74MP0001944_abnormal_pancreas_morphology1.12111773
75MP0003763_abnormal_thymus_physiology1.10212543
76MP0000689_abnormal_spleen_morphology1.09437072
77MP0000313_abnormal_cell_death1.07982721
78MP0008058_abnormal_DNA_repair1.07901699
79MP0005319_abnormal_enzyme/_coenzyme1.07349956
80MP0002693_abnormal_pancreas_physiology1.07039496
81MP0005379_endocrine/exocrine_gland_phen1.06203444
82MP0001293_anophthalmia1.06167234
83MP0001881_abnormal_mammary_gland1.04457129
84MP0010094_abnormal_chromosome_stability1.02582329
85MP0002160_abnormal_reproductive_system1.01180201
86MP0002722_abnormal_immune_system1.00369259
87MP0002098_abnormal_vibrissa_morphology0.99938506
88MP0001727_abnormal_embryo_implantation0.99373319
89MP0001270_distended_abdomen0.99044674
90MP0002019_abnormal_tumor_incidence0.97096390
91MP0001984_abnormal_olfaction0.96540832
92MP0003191_abnormal_cellular_cholesterol0.96059641
93MP0000516_abnormal_urinary_system0.96007490
94MP0005367_renal/urinary_system_phenotyp0.96007490
95MP0002163_abnormal_gland_morphology0.95758759
96MP0009780_abnormal_chondrocyte_physiolo0.94909788
97MP0004233_abnormal_muscle_weight0.94862220
98MP0004782_abnormal_surfactant_physiolog0.94196967
99MP0003786_premature_aging0.93555591
100MP0005187_abnormal_penis_morphology0.92600651
101MP0002697_abnormal_eye_size0.92576762
102MP0002085_abnormal_embryonic_tissue0.92434967
103MP0000627_abnormal_mammary_gland0.91111281
104MP0000685_abnormal_immune_system0.90052408
105MP0002398_abnormal_bone_marrow0.89820196
106MP0002139_abnormal_hepatobiliary_system0.89210347
107MP0003806_abnormal_nucleotide_metabolis0.89177378
108MP0000566_synostosis0.88884106
109MP0002210_abnormal_sex_determination0.88180821
110MP0000350_abnormal_cell_proliferation0.87589388
111MP0003136_yellow_coat_color0.86225647
112MP0001529_abnormal_vocalization0.86027614
113MP0008995_early_reproductive_senescence0.85659493
114MP0005253_abnormal_eye_physiology0.85344247
115MP0002084_abnormal_developmental_patter0.84676272
116MP0000465_gastrointestinal_hemorrhage0.84527644
117MP0002928_abnormal_bile_duct0.84056294
118MP0002429_abnormal_blood_cell0.83917373
119MP0000858_altered_metastatic_potential0.83858831
120MP0008875_abnormal_xenobiotic_pharmacok0.83718634
121MP0000538_abnormal_urinary_bladder0.83108449
122MP0002075_abnormal_coat/hair_pigmentati0.82260999
123MP0010678_abnormal_skin_adnexa0.82225500
124MP0005085_abnormal_gallbladder_physiolo0.81628127
125MP0001849_ear_inflammation0.79743073
126MP0005380_embryogenesis_phenotype0.78828181
127MP0001672_abnormal_embryogenesis/_devel0.78828181
128MP0001145_abnormal_male_reproductive0.78792468
129MP0002088_abnormal_embryonic_growth/wei0.78689274
130MP0001919_abnormal_reproductive_system0.78460964
131MP0003283_abnormal_digestive_organ0.78249544
132MP0003937_abnormal_limbs/digits/tail_de0.78175438
133MP0000598_abnormal_liver_morphology0.78055447
134MP0000647_abnormal_sebaceous_gland0.78017817
135MP0003984_embryonic_growth_retardation0.77644074
136MP0002078_abnormal_glucose_homeostasis0.77569386
137MP0001929_abnormal_gametogenesis0.77101719
138MP0001764_abnormal_homeostasis0.76491710
139MP0009785_altered_susceptibility_to0.75520934
140MP0000716_abnormal_immune_system0.75509160
141MP0005310_abnormal_salivary_gland0.75370297
142MP0000653_abnormal_sex_gland0.74576367
143MP0000613_abnormal_salivary_gland0.74220580
144MP0001853_heart_inflammation0.74176215
145MP0009643_abnormal_urine_homeostasis0.73897835
146MP0009333_abnormal_splenocyte_physiolog0.73816960
147MP0000013_abnormal_adipose_tissue0.73790311
148MP0002127_abnormal_cardiovascular_syste0.73325654
149MP0004019_abnormal_vitamin_homeostasis0.72481787
150MP0002751_abnormal_autonomic_nervous0.71608998
151MP0010368_abnormal_lymphatic_system0.71311047
152MP0000609_abnormal_liver_physiology0.70122512
153MP0002405_respiratory_system_inflammati0.69985556
154MP0002102_abnormal_ear_morphology0.69973608
155MP0005058_abnormal_lysosome_morphology0.69362502
156MP0003656_abnormal_erythrocyte_physiolo0.68737363
157MP0000343_altered_response_to0.68580999
158MP0005025_abnormal_response_to0.67847113
159MP0002736_abnormal_nociception_after0.67409892
160MP0000427_abnormal_hair_cycle0.66658206
161MP0005389_reproductive_system_phenotype0.66432396
162MP0005623_abnormal_meninges_morphology0.66208741
163MP0005636_abnormal_mineral_homeostasis0.65948687
164MP0002086_abnormal_extraembryonic_tissu0.65774614
165MP0002796_impaired_skin_barrier0.62271625
166MP0001756_abnormal_urination0.61777890
167MP0003943_abnormal_hepatobiliary_system0.61591945
168MP0000462_abnormal_digestive_system0.61410435

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.05527263
2Reduced antithrombin III activity (HP:0001976)4.76094407
3Hepatoblastoma (HP:0002884)4.35760588
4Type I transferrin isoform profile (HP:0003642)4.18744510
5Hyperinsulinemic hypoglycemia (HP:0000825)4.16330413
6Aplastic anemia (HP:0001915)4.16194190
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.13474943
8Ragged-red muscle fibers (HP:0003200)4.07250974
9Multiple enchondromatosis (HP:0005701)3.80737172
10Abnormality of the intrinsic pathway (HP:0010989)3.74896671
11Abnormality of glycolysis (HP:0004366)3.72349263
12Chromsome breakage (HP:0040012)3.69582140
13Abnormal mitochondria in muscle tissue (HP:0008316)3.59299269
14Hypochromic microcytic anemia (HP:0004840)3.56296902
15Acute encephalopathy (HP:0006846)3.54515179
16Hypoplasia of the fovea (HP:0007750)3.54343560
17Aplasia/Hypoplasia of the fovea (HP:0008060)3.54343560
18Hepatic necrosis (HP:0002605)3.52161611
19Increased serum pyruvate (HP:0003542)3.46989772
20Acute necrotizing encephalopathy (HP:0006965)3.46936840
21Bifid tongue (HP:0010297)3.37489921
22Hepatocellular necrosis (HP:0001404)3.22104558
23Abnormality of the lower motor neuron (HP:0002366)3.13699527
24Abnormal protein glycosylation (HP:0012346)3.12611855
25Abnormal glycosylation (HP:0012345)3.12611855
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.12611855
27Abnormal protein N-linked glycosylation (HP:0012347)3.12611855
28Mitochondrial inheritance (HP:0001427)3.07221181
29Abnormality of the fovea (HP:0000493)3.05383170
30Increased CSF lactate (HP:0002490)3.03235722
31Cerebral edema (HP:0002181)2.98589058
32Abnormal umbilical cord blood vessels (HP:0011403)2.94299695
33Single umbilical artery (HP:0001195)2.94299695
34Abnormality of the fetal cardiovascular system (HP:0010948)2.94299695
35Rib fusion (HP:0000902)2.89576311
36Microvesicular hepatic steatosis (HP:0001414)2.82043834
37Pendular nystagmus (HP:0012043)2.81868934
38Reticulocytopenia (HP:0001896)2.81419964
39Abnormality of the preputium (HP:0100587)2.79316551
40Abnormality of the umbilical cord (HP:0010881)2.75193074
41Microretrognathia (HP:0000308)2.73009892
42Progressive macrocephaly (HP:0004481)2.72763507
43Absent rod-and cone-mediated responses on ERG (HP:0007688)2.70745171
44Meckel diverticulum (HP:0002245)2.70496147
453-Methylglutaconic aciduria (HP:0003535)2.69107303
46Progressive muscle weakness (HP:0003323)2.66809596
47Ependymoma (HP:0002888)2.55557857
48Generalized aminoaciduria (HP:0002909)2.55357469
49Gout (HP:0001997)2.55199149
50Lactic acidosis (HP:0003128)2.55173056
51Abnormality of glycolipid metabolism (HP:0010969)2.53369241
52Abnormality of liposaccharide metabolism (HP:0010968)2.53369241
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.53369241
54Abnormality of the ileum (HP:0001549)2.51542249
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.50387504
56Increased serum lactate (HP:0002151)2.49900118
57Nasal polyposis (HP:0100582)2.42096808
58Abnormality of chromosome stability (HP:0003220)2.40775283
59Elevated erythrocyte sedimentation rate (HP:0003565)2.40652232
60Aplasia/Hypoplasia of the sacrum (HP:0008517)2.37505063
61Poor head control (HP:0002421)2.36138017
62Megaloblastic anemia (HP:0001889)2.35220004
63Tongue fasciculations (HP:0001308)2.34514568
64Spinal muscular atrophy (HP:0007269)2.34269850
65Nephroblastoma (Wilms tumor) (HP:0002667)2.32152785
66Proximal tubulopathy (HP:0000114)2.32022332
67Abnormal rod and cone electroretinograms (HP:0008323)2.31589082
68Abnormality of methionine metabolism (HP:0010901)2.30257281
69Respiratory failure (HP:0002878)2.28572232
70Nausea (HP:0002018)2.27399915
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26351230
72Abnormalities of placenta or umbilical cord (HP:0001194)2.25405536
73Increased hepatocellular lipid droplets (HP:0006565)2.23080574
74Exercise intolerance (HP:0003546)2.22788641
75Hyperammonemia (HP:0001987)2.21276346
76Abnormal lung lobation (HP:0002101)2.20039139
77Thrombocytosis (HP:0001894)2.19895227
78Hypokinesia (HP:0002375)2.18713427
79Testicular atrophy (HP:0000029)2.17228391
80Ketoacidosis (HP:0001993)2.15908884
81Abnormality of small intestinal villus morphology (HP:0011472)2.15590764
82Villous atrophy (HP:0011473)2.15590764
83Hypothermia (HP:0002045)2.15454354
84Abnormality of T cell physiology (HP:0011840)2.13640468
85Cortical visual impairment (HP:0100704)2.13551733
86Abnormality of the nasal mucosa (HP:0000433)2.13259539
87Aplasia/Hypoplasia of the macula (HP:0008059)2.12839886
88Lethargy (HP:0001254)2.11870256
89Cholecystitis (HP:0001082)2.11632358
90Abnormal gallbladder physiology (HP:0012438)2.11632358
91Cutaneous melanoma (HP:0012056)2.10768463
92Duodenal stenosis (HP:0100867)2.10652500
93Small intestinal stenosis (HP:0012848)2.10652500
94Embryonal renal neoplasm (HP:0011794)2.08929227
95Rhabdomyosarcoma (HP:0002859)2.08219791
96Macrocytic anemia (HP:0001972)2.07405074
97Abnormality of the anterior horn cell (HP:0006802)2.06972155
98Degeneration of anterior horn cells (HP:0002398)2.06972155
99Partial duplication of thumb phalanx (HP:0009944)2.06662800
100Orthostatic hypotension (HP:0001278)2.06559904
101Neoplasm of striated muscle (HP:0009728)2.05137041
102Abnormality of the heme biosynthetic pathway (HP:0010472)2.04323521
103Hyperventilation (HP:0002883)2.03879283
104Abnormality of aromatic amino acid family metabolism (HP:0004338)2.03447525
105Lipid accumulation in hepatocytes (HP:0006561)2.00887192
106Increased intramyocellular lipid droplets (HP:0012240)1.99736978
107Pancytopenia (HP:0001876)1.98665887
108Vaginal fistula (HP:0004320)1.98347237
109Congenital stationary night blindness (HP:0007642)1.97748237
110Pancreatic islet-cell hyperplasia (HP:0004510)1.96671896
111Myelodysplasia (HP:0002863)1.95888225
112Increased nuchal translucency (HP:0010880)1.94475123
113Overlapping toe (HP:0001845)1.94392472
114IgM deficiency (HP:0002850)1.94186075
115Broad foot (HP:0001769)1.92148029
116Aplasia/Hypoplasia affecting the retina (HP:0008061)1.91351723
117Trismus (HP:0000211)1.91147595
118Sparse eyelashes (HP:0000653)1.91130039
119Late onset (HP:0003584)1.90384513
120Renal Fanconi syndrome (HP:0001994)1.90330111
121Hypoglycemic seizures (HP:0002173)1.88371796
122Muscle fibrillation (HP:0010546)1.88097963
123Abnormal cartilage morphology (HP:0002763)1.87722577
124Abnormality of aspartate family amino acid metabolism (HP:0010899)1.87295956
125Rectovaginal fistula (HP:0000143)1.87237876
126Rectal fistula (HP:0100590)1.87237876
127Panhypogammaglobulinemia (HP:0003139)1.86815827
128Microglossia (HP:0000171)1.86397640
129Abnormal tarsal ossification (HP:0008369)1.86250480
130Abnormality of the carotid arteries (HP:0005344)1.85819861
131Hypoplasia of the thymus (HP:0000778)1.85762685
132Hypobetalipoproteinemia (HP:0003563)1.85572654
133Symptomatic seizures (HP:0011145)1.85289695
134Missing ribs (HP:0000921)1.84013798
135Abnormality of urine glucose concentration (HP:0011016)1.83425035
136Glycosuria (HP:0003076)1.83425035
137Abnormality of endocrine pancreas physiology (HP:0012093)1.83397557
138Abnormality of the pancreatic islet cells (HP:0006476)1.83397557
139Septate vagina (HP:0001153)1.82380925
140Facial cleft (HP:0002006)1.81833020
141Atrophy/Degeneration involving motor neurons (HP:0007373)1.80154974
142Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.79895402
143Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78640916
144Absent epiphyses (HP:0010577)1.78640916
145Hyperglycinemia (HP:0002154)1.78045396
146Abnormality of the proximal phalanges of the hand (HP:0009834)1.77582073
147Dicarboxylic aciduria (HP:0003215)1.77255264
148Abnormality of dicarboxylic acid metabolism (HP:0010995)1.77255264
149Cheilitis (HP:0100825)1.75561278
150Episodic fever (HP:0001954)1.73906620
151Opisthotonus (HP:0002179)1.72586889
152Secondary amenorrhea (HP:0000869)1.72151132
153Abnormality of serum amino acid levels (HP:0003112)1.72037580
154Osteomalacia (HP:0002749)1.71818262
155Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71483497
156Bone marrow hypocellularity (HP:0005528)1.71319378
157Preauricular skin tag (HP:0000384)1.69986191
158Patchy hypopigmentation of hair (HP:0011365)1.68944080
159Abnormality of the salivary glands (HP:0010286)1.68555627
160Angiofibromas (HP:0010615)1.68413279
161Adenoma sebaceum (HP:0009720)1.68413279
162Abnormality of alanine metabolism (HP:0010916)1.68271744
163Hyperalaninemia (HP:0003348)1.68271744
164Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68271744
165Abnormality of sulfur amino acid metabolism (HP:0004339)1.66753199
166Intestinal fistula (HP:0100819)1.66709999
167Abnormality of the duodenum (HP:0002246)1.66697266
168Petechiae (HP:0000967)1.66098388
169Abnormality of pyrimidine metabolism (HP:0004353)1.65544636
170Short thumb (HP:0009778)1.64782991
171Myositis (HP:0100614)1.63911646
172Decreased activity of mitochondrial respiratory chain (HP:0008972)1.63661759
173Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.63661759
174Hypoglycemic coma (HP:0001325)1.62652346
175Abnormality of the distal phalanges of the toes (HP:0010182)1.62280763
176Partial duplication of the phalanx of hand (HP:0009999)1.60852927
177Tetraplegia (HP:0002445)1.60740988

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.12081693
2CDK124.59806740
3GRK53.95773447
4EIF2AK13.44066385
5ADRBK23.41000006
6VRK23.30562704
7CSF1R3.07703853
8GRK63.04120019
9GRK12.99738080
10FLT32.93957470
11MST1R2.74819985
12PBK2.72818684
13SRPK12.63458511
14TGFBR22.47794472
15MST42.32307939
16MATK2.29271953
17FRK2.21785843
18BCKDK2.20353993
19ZAK2.00096301
20HIPK21.99765709
21MAPK71.82886273
22TRIM281.81835476
23PRKG21.77772842
24PASK1.70356313
25GRK71.68108431
26CDK81.66943690
27KIT1.59285499
28PLK41.58961621
29CDK71.52863377
30TSSK61.50446801
31PLK31.48504261
32LIMK11.41258346
33NME11.40473315
34STK161.37733378
35MOS1.35930757
36CCNB11.35112171
37BUB11.30013296
38PDK21.25577934
39MET1.24772914
40BRSK21.21155612
41TLK11.19807349
42STK101.17555524
43ZAP701.14979546
44MAPK151.13646532
45NME21.13031157
46FGFR31.10927690
47TTK1.07978973
48TEC1.03871267
49BTK1.02987115
50ERBB31.02442459
51PIM21.00012265
52MYLK0.98818360
53VRK10.98599262
54PAK40.98545583
55CDK190.97102050
56ILK0.96502660
57TESK20.95372444
58RPS6KB20.94033141
59NTRK10.93629121
60CAMK40.93158498
61SCYL20.90727970
62MAPKAPK30.89431564
63CSNK1G30.89059435
64DAPK10.87774953
65SIK30.86206600
66TAF10.85907219
67MUSK0.85118770
68PLK10.85092391
69TAOK30.80744847
70LMTK20.80666777
71ADRBK10.80051456
72IRAK30.80029232
73MAP2K60.79846476
74PRKD30.79607895
75NEK20.78450724
76SMG10.77880602
77CHEK20.76874460
78WEE10.74766836
79MAP4K10.73377044
80INSRR0.71463721
81CAMKK20.70669616
82STK390.70380063
83BRSK10.69910205
84TGFBR10.69837351
85LRRK20.69699896
86CDC70.68621582
87CSNK1G10.67844463
88PNCK0.67355297
89ITK0.66756196
90DYRK30.65768767
91EIF2AK30.64087225
92STK40.63680996
93CSNK1A1L0.63435583
94MAP3K120.60546947
95ACVR1B0.60247964
96TYRO30.59248063
97WNK10.59231501
98PRKCI0.57710303
99SYK0.57680264
100CDK90.55870108
101MAP3K80.54329690
102ABL20.53941159
103SIK10.53034507
104EPHB20.52914157
105NUAK10.52512848
106TNIK0.51046376
107JAK30.49954967
108BMPR1B0.49588510
109MINK10.49251265
110ATM0.48664461
111EPHA20.48474701
112ATR0.47987332
113FER0.47842399
114DYRK1B0.47713010
115CSNK2A10.46439095
116MAP2K40.46418039
117AKT30.45293984
118ERBB40.44138280
119CSNK2A20.43529830
120BCR0.43083521
121CDK180.42536375
122TESK10.42370092
123DAPK30.40924646
124CDK140.40907336
125TNK20.39994807
126MAP3K30.39842781
127PRKCD0.39083243
128PTK20.39050041
129AKT20.38916383
130MARK20.38816637
131NEK10.38581523
132RPS6KA50.37823396
133IGF1R0.37436619
134KDR0.36749392
135PAK10.36745186
136CDK150.36453206
137CSNK1G20.36427304
138PIK3CG0.35230592
139TRIB30.35164924
140AURKB0.34057522
141IKBKB0.32820659
142CDK10.32672844
143CDK11A0.32366738
144MAP3K100.31159523
145EIF2AK20.30320436
146AURKA0.30097948
147RPS6KA40.29949873
148MKNK10.29461330
149MAPK40.28969830
150TIE10.28747563
151MAPKAPK50.28632391
152CAMK2D0.28439688
153BRAF0.28156035
154EEF2K0.27955634
155CHEK10.27491133
156LYN0.26246711
157PKN20.25896034
158PRKD20.24628957
159NLK0.24455992

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.36251485
2Protein export_Homo sapiens_hsa030603.27549479
3DNA replication_Homo sapiens_hsa030303.23055457
4Vitamin B6 metabolism_Homo sapiens_hsa007503.17606977
5Fructose and mannose metabolism_Homo sapiens_hsa000513.15191580
6Maturity onset diabetes of the young_Homo sapiens_hsa049503.06787231
7Galactose metabolism_Homo sapiens_hsa000523.00853077
8Folate biosynthesis_Homo sapiens_hsa007902.69479471
9Other glycan degradation_Homo sapiens_hsa005112.69201806
10Mismatch repair_Homo sapiens_hsa034302.37493460
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28205622
12Base excision repair_Homo sapiens_hsa034102.22908690
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.20448106
14Fatty acid elongation_Homo sapiens_hsa000622.16948777
15Oxidative phosphorylation_Homo sapiens_hsa001902.13793873
16Glycosaminoglycan degradation_Homo sapiens_hsa005312.05754784
17Ribosome_Homo sapiens_hsa030102.01286979
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.00631205
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.92798893
20Parkinsons disease_Homo sapiens_hsa050121.92704734
21N-Glycan biosynthesis_Homo sapiens_hsa005101.89754840
22Arachidonic acid metabolism_Homo sapiens_hsa005901.84683687
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78039218
24Homologous recombination_Homo sapiens_hsa034401.77200099
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.76670601
26Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.74144349
27Pyrimidine metabolism_Homo sapiens_hsa002401.60014607
28Thyroid cancer_Homo sapiens_hsa052161.55264927
29One carbon pool by folate_Homo sapiens_hsa006701.49614916
30Huntingtons disease_Homo sapiens_hsa050161.44291325
31Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.35451541
32Selenocompound metabolism_Homo sapiens_hsa004501.29759575
33Cell cycle_Homo sapiens_hsa041101.28997382
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.27705010
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27377502
36RNA degradation_Homo sapiens_hsa030181.27114253
37Non-homologous end-joining_Homo sapiens_hsa034501.26912369
38Nucleotide excision repair_Homo sapiens_hsa034201.23977498
39Pentose phosphate pathway_Homo sapiens_hsa000301.22601605
40Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22517971
41Propanoate metabolism_Homo sapiens_hsa006401.21800637
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.21486062
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.19050705
44Alzheimers disease_Homo sapiens_hsa050101.17580677
45RNA transport_Homo sapiens_hsa030131.13284896
46Sulfur relay system_Homo sapiens_hsa041221.11256104
47Regulation of autophagy_Homo sapiens_hsa041401.10525541
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.06791214
49Primary immunodeficiency_Homo sapiens_hsa053401.03609707
50Phototransduction_Homo sapiens_hsa047441.02768066
51Biosynthesis of amino acids_Homo sapiens_hsa012301.01810009
52RNA polymerase_Homo sapiens_hsa030200.99950836
53Carbon metabolism_Homo sapiens_hsa012000.98439447
54Spliceosome_Homo sapiens_hsa030400.98027567
55Proteasome_Homo sapiens_hsa030500.97068485
56Linoleic acid metabolism_Homo sapiens_hsa005910.95958227
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.92691897
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90622955
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89886075
60Steroid biosynthesis_Homo sapiens_hsa001000.89590783
61Lysosome_Homo sapiens_hsa041420.88789529
62Fatty acid metabolism_Homo sapiens_hsa012120.88346221
63Purine metabolism_Homo sapiens_hsa002300.87167360
64Arginine and proline metabolism_Homo sapiens_hsa003300.86627040
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.85812914
66Antigen processing and presentation_Homo sapiens_hsa046120.82055262
67Arginine biosynthesis_Homo sapiens_hsa002200.78773745
68Legionellosis_Homo sapiens_hsa051340.78702080
69Basal transcription factors_Homo sapiens_hsa030220.77673161
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76722328
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75089976
72Chemical carcinogenesis_Homo sapiens_hsa052040.72159770
73Fanconi anemia pathway_Homo sapiens_hsa034600.71774687
74Fat digestion and absorption_Homo sapiens_hsa049750.71137865
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70640536
76Starch and sucrose metabolism_Homo sapiens_hsa005000.70051462
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67850719
78Vitamin digestion and absorption_Homo sapiens_hsa049770.67818764
79Butanoate metabolism_Homo sapiens_hsa006500.63010265
80Oocyte meiosis_Homo sapiens_hsa041140.62387844
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61615758
82p53 signaling pathway_Homo sapiens_hsa041150.60699755
83Tryptophan metabolism_Homo sapiens_hsa003800.60486204
84Herpes simplex infection_Homo sapiens_hsa051680.60007255
85Metabolic pathways_Homo sapiens_hsa011000.59628656
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.59100845
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59070918
88Acute myeloid leukemia_Homo sapiens_hsa052210.58561272
89Vibrio cholerae infection_Homo sapiens_hsa051100.58500921
90Peroxisome_Homo sapiens_hsa041460.56575466
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54495841
92Alcoholism_Homo sapiens_hsa050340.52104995
93Tyrosine metabolism_Homo sapiens_hsa003500.52050908
94Pyruvate metabolism_Homo sapiens_hsa006200.51752335
95Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50091146
96Inositol phosphate metabolism_Homo sapiens_hsa005620.49669022
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49233941
98Phenylalanine metabolism_Homo sapiens_hsa003600.48996167
99Systemic lupus erythematosus_Homo sapiens_hsa053220.48152015
100mRNA surveillance pathway_Homo sapiens_hsa030150.45954940
101ABC transporters_Homo sapiens_hsa020100.44708112
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43769747
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.41370177
104Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.38963753
105mTOR signaling pathway_Homo sapiens_hsa041500.38911377
106Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36291470
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35458616
108Mineral absorption_Homo sapiens_hsa049780.33528843
109Sphingolipid metabolism_Homo sapiens_hsa006000.31513610
110Caffeine metabolism_Homo sapiens_hsa002320.29173333
111Steroid hormone biosynthesis_Homo sapiens_hsa001400.28789757
112Bladder cancer_Homo sapiens_hsa052190.27560694
113Cardiac muscle contraction_Homo sapiens_hsa042600.27233480
114beta-Alanine metabolism_Homo sapiens_hsa004100.26994094
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26751811
116Ovarian steroidogenesis_Homo sapiens_hsa049130.25084263
117Renin-angiotensin system_Homo sapiens_hsa046140.23722625
118Cyanoamino acid metabolism_Homo sapiens_hsa004600.23337160
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.23029765
120Primary bile acid biosynthesis_Homo sapiens_hsa001200.22987419
121Collecting duct acid secretion_Homo sapiens_hsa049660.22419872
122Fatty acid degradation_Homo sapiens_hsa000710.22034822
123Non-small cell lung cancer_Homo sapiens_hsa052230.18467113
124Glutathione metabolism_Homo sapiens_hsa004800.17089323
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16777078
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.16163871
127Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.15376661
128Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.14948795
129Sulfur metabolism_Homo sapiens_hsa009200.14431714
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12962119
131Hematopoietic cell lineage_Homo sapiens_hsa046400.12737476
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.11474707
133Apoptosis_Homo sapiens_hsa042100.11079501
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.10539682
135Complement and coagulation cascades_Homo sapiens_hsa046100.09780461
136Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.08280527

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