TMEM107

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.16418555
2axonemal dynein complex assembly (GO:0070286)8.72299444
3regulation of somitogenesis (GO:0014807)8.60499974
4axoneme assembly (GO:0035082)7.95980774
5GTP biosynthetic process (GO:0006183)7.71461544
6epithelial cilium movement (GO:0003351)7.33638958
7UTP biosynthetic process (GO:0006228)7.00138991
8prenylation (GO:0097354)6.54632755
9protein prenylation (GO:0018342)6.54632755
10nucleoside diphosphate phosphorylation (GO:0006165)6.50085092
11cilium or flagellum-dependent cell motility (GO:0001539)6.48479207
12intraciliary transport (GO:0042073)6.40581067
13guanosine-containing compound biosynthetic process (GO:1901070)6.35295038
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.23622674
15UTP metabolic process (GO:0046051)6.23042661
16replicative senescence (GO:0090399)6.16002366
17DNA integration (GO:0015074)6.04227875
18sulfation (GO:0051923)5.98719210
19positive regulation of RNA splicing (GO:0033120)5.93503788
20CTP biosynthetic process (GO:0006241)5.69786523
21CTP metabolic process (GO:0046036)5.69786523
22protein K11-linked deubiquitination (GO:0035871)5.67664611
23pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)5.30928319
24motile cilium assembly (GO:0044458)5.04288158
25pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)5.02660987
26negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.95358614
27negative regulation of T-helper cell differentiation (GO:0045623)4.95358614
28hair cycle (GO:0042633)4.91901376
29molting cycle (GO:0042303)4.91901376
30cAMP biosynthetic process (GO:0006171)4.85488218
31pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)4.83681739
32detection of chemical stimulus involved in sensory perception of smell (GO:0050911)4.75705414
33pyrimidine nucleoside triphosphate metabolic process (GO:0009147)4.74551136
34viral mRNA export from host cell nucleus (GO:0046784)4.73083477
35activation of protein kinase A activity (GO:0034199)4.72399527
36ventricular system development (GO:0021591)4.69825508
37positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)4.58634556
38hematopoietic stem cell proliferation (GO:0071425)4.53899582
39DNA replication-dependent nucleosome assembly (GO:0006335)4.51730469
40DNA replication-dependent nucleosome organization (GO:0034723)4.51730469
41* cilium organization (GO:0044782)4.35280527
42deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.34075604
43left/right axis specification (GO:0070986)4.27297215
44regulation of DNA damage checkpoint (GO:2000001)4.26621062
45leukotriene biosynthetic process (GO:0019370)4.23412585
46* cilium assembly (GO:0042384)4.13141082
47negative regulation of systemic arterial blood pressure (GO:0003085)4.11587309
48nucleoside diphosphate metabolic process (GO:0009132)4.07401176
49innate immune response in mucosa (GO:0002227)4.07305757
50tooth mineralization (GO:0034505)4.06239654
51regulation of cilium movement (GO:0003352)4.01468930
52nucleotide phosphorylation (GO:0046939)4.01360820
53pyrimidine ribonucleoside biosynthetic process (GO:0046132)3.94047045
54tryptophan metabolic process (GO:0006568)3.92859982
55signal peptide processing (GO:0006465)3.80399842
56negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.79111608
57T cell mediated immunity (GO:0002456)3.77899620
58negative regulation of type 2 immune response (GO:0002829)3.77701273
59cilium morphogenesis (GO:0060271)3.77030471
60regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.73502462
61pyrimidine ribonucleotide biosynthetic process (GO:0009220)3.72829546
62pyrimidine nucleotide biosynthetic process (GO:0006221)3.68422780
63positive regulation of cAMP-mediated signaling (GO:0043950)3.67523818
64positive regulation of protein sumoylation (GO:0033235)3.62886778
65centriole assembly (GO:0098534)3.61509232
66post-anal tail morphogenesis (GO:0036342)3.57149592
67negative regulation of alpha-beta T cell differentiation (GO:0046639)3.55103815
68regulation of T-helper 2 cell differentiation (GO:0045628)3.47842125
69SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.47822958
70mucosal immune response (GO:0002385)3.45941799
71cotranslational protein targeting to membrane (GO:0006613)3.43565943
72deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.43213931
73centriole replication (GO:0007099)3.42656502
74detection of chemical stimulus involved in sensory perception (GO:0050907)3.42304701
75positive regulation of prostaglandin secretion (GO:0032308)3.41619158
76regulation of skeletal muscle contraction (GO:0014819)3.40230534
77protein targeting to ER (GO:0045047)3.39598464
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.38276611
79regulation of T-helper 1 cell differentiation (GO:0045625)3.38081897
80positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.37935636
81pyrimidine nucleoside biosynthetic process (GO:0046134)3.36909425
82negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.35749994
83nonmotile primary cilium assembly (GO:0035058)3.32035135
84mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30294239
85cellular response to ethanol (GO:0071361)3.28310758
86purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.28176305
87organ or tissue specific immune response (GO:0002251)3.26184342
88microtubule bundle formation (GO:0001578)3.23227431
89pyrimidine ribonucleotide metabolic process (GO:0009218)3.22482547
90COPI coating of Golgi vesicle (GO:0048205)3.22451299
91Golgi transport vesicle coating (GO:0048200)3.22451299
92establishment of protein localization to endoplasmic reticulum (GO:0072599)3.21823049
93purine nucleoside triphosphate biosynthetic process (GO:0009145)3.20895673
94protein localization to endoplasmic reticulum (GO:0070972)3.20391842
95indolalkylamine metabolic process (GO:0006586)3.12612297
96ribosomal small subunit assembly (GO:0000028)3.12501647
97mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12095803
98* cellular component assembly involved in morphogenesis (GO:0010927)3.12075280
99positive regulation of T-helper 1 type immune response (GO:0002827)3.09851483
100purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.09783205
1013-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.09783205
102detection of light stimulus involved in sensory perception (GO:0050962)3.09615086
103detection of light stimulus involved in visual perception (GO:0050908)3.09615086
104pyrimidine-containing compound biosynthetic process (GO:0072528)3.09469807
105ATP synthesis coupled proton transport (GO:0015986)3.07906797
106energy coupled proton transport, down electrochemical gradient (GO:0015985)3.07906797
107righting reflex (GO:0060013)3.07889286
108DNA replication initiation (GO:0006270)3.05650119
109respiratory chain complex IV assembly (GO:0008535)3.04746028
110positive regulation of digestive system process (GO:0060456)3.03858492
111flavonoid metabolic process (GO:0009812)3.03576579
112protein complex biogenesis (GO:0070271)3.03126613
113regulation of prostaglandin secretion (GO:0032306)3.02117614
114positive regulation of cardiac muscle cell differentiation (GO:2000727)3.00682620
115ribonucleoside triphosphate biosynthetic process (GO:0009201)3.00344861
116cell differentiation involved in embryonic placenta development (GO:0060706)3.00177514
117intra-S DNA damage checkpoint (GO:0031573)2.99730396
118telomere maintenance via semi-conservative replication (GO:0032201)2.99093235
119pyrimidine ribonucleoside metabolic process (GO:0046131)2.96242786
120purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.94746827
121epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.93680941
122nucleoside triphosphate biosynthetic process (GO:0009142)2.92911186
123branching involved in labyrinthine layer morphogenesis (GO:0060670)2.92672198
124positive regulation of heart rate (GO:0010460)2.91869802
125protein maturation by protein folding (GO:0022417)2.91067858
126spleen development (GO:0048536)2.90248266
127transcription elongation from RNA polymerase I promoter (GO:0006362)2.88187325
128antibacterial humoral response (GO:0019731)2.87278972
129DNA deamination (GO:0045006)2.87080851
130protein localization to cilium (GO:0061512)2.86833994
131forebrain neuron development (GO:0021884)2.86294746
132regulation of mitochondrial translation (GO:0070129)2.86052872
133cell proliferation in forebrain (GO:0021846)2.85384647
134otic vesicle formation (GO:0030916)2.84601601
135dendritic spine morphogenesis (GO:0060997)2.84345116
136kynurenine metabolic process (GO:0070189)2.84143873
137one-carbon compound transport (GO:0019755)2.82133284
138multicellular organismal aging (GO:0010259)2.80171400
139positive regulation of systemic arterial blood pressure (GO:0003084)2.80046496
140seminiferous tubule development (GO:0072520)2.79905162
141indole-containing compound catabolic process (GO:0042436)2.79145317
142indolalkylamine catabolic process (GO:0046218)2.79145317
143tryptophan catabolic process (GO:0006569)2.79145317
144pyrimidine nucleotide metabolic process (GO:0006220)2.79134105
145mitochondrial respiratory chain complex assembly (GO:0033108)2.78501569
146prostate gland growth (GO:0060736)2.77483809
147positive regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902043)2.77190202
148transcription elongation from RNA polymerase III promoter (GO:0006385)2.76892272
149termination of RNA polymerase III transcription (GO:0006386)2.76892272
150proteasome assembly (GO:0043248)2.75632984
151cAMP metabolic process (GO:0046058)2.72646538
1522-deoxyribonucleotide biosynthetic process (GO:0009265)2.72292230
153deoxyribose phosphate biosynthetic process (GO:0046385)2.72292230
154regulation of germinal center formation (GO:0002634)2.70601389
155detection of chemical stimulus (GO:0009593)2.70229998
156antimicrobial humoral response (GO:0019730)2.69765749
157viral transcription (GO:0019083)2.69315030
158positive regulation of mitochondrial fission (GO:0090141)2.69045512
159leukotriene metabolic process (GO:0006691)2.68309793
160DNA strand elongation involved in DNA replication (GO:0006271)2.68258651
1617-methylguanosine mRNA capping (GO:0006370)2.67878267
162telomere maintenance via recombination (GO:0000722)2.67553469
163negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.67079222
164neural tube formation (GO:0001841)2.66475163
165chromatin remodeling at centromere (GO:0031055)2.66298927
166NADH dehydrogenase complex assembly (GO:0010257)2.65854724
167mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.65854724
168mitochondrial respiratory chain complex I assembly (GO:0032981)2.65854724
169DNA strand elongation (GO:0022616)2.65817334
170cerebellar Purkinje cell differentiation (GO:0021702)2.64933235
171establishment of integrated proviral latency (GO:0075713)2.64854572
172somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64636449
173somatic hypermutation of immunoglobulin genes (GO:0016446)2.64636449
174CENP-A containing nucleosome assembly (GO:0034080)2.63842371
175microtubule-based movement (GO:0007018)2.63782630
176cellular response to exogenous dsRNA (GO:0071360)2.63482420
177adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189)2.62891312
178DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.62874051
179regulation of cAMP-mediated signaling (GO:0043949)2.62591330
180regulation of endothelial cell differentiation (GO:0045601)2.62482455
181hepatocyte apoptotic process (GO:0097284)2.62345512
182phosphatidylinositol acyl-chain remodeling (GO:0036149)2.61148269
183establishment of protein localization to mitochondrial membrane (GO:0090151)2.60976556
184DNA replication checkpoint (GO:0000076)2.60453453
1857-methylguanosine RNA capping (GO:0009452)2.59666153
186RNA capping (GO:0036260)2.59666153
187translation (GO:0006412)2.59269664
188transcription-coupled nucleotide-excision repair (GO:0006283)2.59116483
189keratinocyte development (GO:0003334)2.59035544
190electron transport chain (GO:0022900)2.58330396
191translational termination (GO:0006415)2.57694943
192respiratory electron transport chain (GO:0022904)2.57573137
193nephron tubule morphogenesis (GO:0072078)2.57474445
194nephron epithelium morphogenesis (GO:0072088)2.57474445
195regulation of cell proliferation involved in kidney development (GO:1901722)2.56815537
196protein K48-linked deubiquitination (GO:0071108)2.56793052

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.39068331
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse5.07035689
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.81766895
4RBPJ_22232070_ChIP-Seq_NCS_Mouse4.52498886
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.38491664
6E2F7_22180533_ChIP-Seq_HELA_Human4.37880628
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.89688625
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.56725851
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.52474328
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.30096170
11* EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08279732
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.94422931
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.90272097
14AR_21572438_ChIP-Seq_LNCaP_Human2.89835143
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.77942543
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.75466739
17TP53_16413492_ChIP-PET_HCT116_Human2.72281109
18IGF1R_20145208_ChIP-Seq_DFB_Human2.67446307
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64131681
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.46637996
21CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44623076
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.40308249
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.39107179
24MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36868786
25VDR_23849224_ChIP-Seq_CD4+_Human2.29201915
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.28893187
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.21416430
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.11664250
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10991366
30* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04590221
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00845435
32VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human2.00290314
33FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99283163
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.98061254
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.97434468
36ELK1_19687146_ChIP-ChIP_HELA_Human1.96427206
37GABP_19822575_ChIP-Seq_HepG2_Human1.90839093
38E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86999060
39FOXP3_21729870_ChIP-Seq_TREG_Human1.86625784
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85368855
41* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.85122160
42DCP1A_22483619_ChIP-Seq_HELA_Human1.77311481
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74277707
44TTF2_22483619_ChIP-Seq_HELA_Human1.73763955
45MYC_19079543_ChIP-ChIP_MESCs_Mouse1.73005579
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.67847567
47* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.67524438
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66530814
49FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65508056
50GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63818199
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.62761777
52GATA1_22025678_ChIP-Seq_K562_Human1.62746859
53THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62523958
54PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62298920
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59879092
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.54699096
57* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54563801
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54049167
59XRN2_22483619_ChIP-Seq_HELA_Human1.52924278
60* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49840052
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46277283
62TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.45779254
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.44493625
64ZNF274_21170338_ChIP-Seq_K562_Hela1.42103576
65VDR_22108803_ChIP-Seq_LS180_Human1.38688508
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.38467790
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.35167830
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.35150408
69HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.34457982
70LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31809510
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.29565248
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28090624
73HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26821398
74MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26698669
75ER_23166858_ChIP-Seq_MCF-7_Human1.25556411
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22768792
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21642506
78FUS_26573619_Chip-Seq_HEK293_Human1.21081268
79ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20072588
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.19756062
81RXR_22108803_ChIP-Seq_LS180_Human1.16655540
82POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.14251560
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13823592
84ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.13792758
85ERG_20517297_ChIP-Seq_VCAP_Human1.12423476
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.12188604
87IRF1_19129219_ChIP-ChIP_H3396_Human1.11602554
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10256273
89YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08995725
90SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07937521
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07272187
92GBX2_23144817_ChIP-Seq_PC3_Human1.05405238
93SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.04206242
94MYC_18940864_ChIP-ChIP_HL60_Human1.03847971
95TDRD3_21172665_ChIP-Seq_MCF-7_Human1.02715857
96E2F1_21310950_ChIP-Seq_MCF-7_Human1.02254108
97RNF2_27304074_Chip-Seq_NSC_Mouse1.02079745
98POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01936106
99ARNT_22903824_ChIP-Seq_MCF-7_Human1.01295540
100SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01293889
101* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.00291094
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00132699
103SMAD3_21741376_ChIP-Seq_EPCs_Human0.99534160
104STAT3_23295773_ChIP-Seq_U87_Human0.99247233
105AR_21909140_ChIP-Seq_LNCAP_Human0.98199370
106* EWS_26573619_Chip-Seq_HEK293_Human0.97019312
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96978657
108BCAT_22108803_ChIP-Seq_LS180_Human0.96752164
109* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.96322292
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94875105
111TP63_19390658_ChIP-ChIP_HaCaT_Human0.93864689
112AHR_22903824_ChIP-Seq_MCF-7_Human0.93094399
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91773760
114ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91533655
115FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.90328271
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.89984536
117GATA3_21867929_ChIP-Seq_CD8_Mouse0.89908955
118SCL_19346495_ChIP-Seq_HPC-7_Human0.89090289
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89022991
120GATA1_26923725_Chip-Seq_HPCs_Mouse0.88903305
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.88872013
122PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88330651
123FOXA1_25329375_ChIP-Seq_VCAP_Human0.87765400
124FOXA1_27270436_Chip-Seq_PROSTATE_Human0.87765400
125* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87724494
126* HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.87399435
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86239605
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86010130
129ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85997549
130* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83916904
131* CBP_20019798_ChIP-Seq_JUKART_Human0.83916904
132* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.83833178
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83730550
134SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83690639
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83390831
136SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.83195048
137FLI1_27457419_Chip-Seq_LIVER_Mouse0.82963494
138* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82287521
139* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.80673097
140GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80498091
141AR_20517297_ChIP-Seq_VCAP_Human0.80262387
142SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80050544
143FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.79478272
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.79377120
145* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79311235
146MYB_26560356_Chip-Seq_TH2_Human0.79037328
147MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.78359622
148POU3F2_20337985_ChIP-ChIP_501MEL_Human0.75486274
149NOTCH1_21737748_ChIP-Seq_TLL_Human0.75287247
150YY1_22570637_ChIP-Seq_MALME-3M_Human0.74241513
151JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74198136
152SRY_22984422_ChIP-ChIP_TESTIS_Rat0.74152015
153SMAD4_21741376_ChIP-Seq_EPCs_Human0.73745590
154JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73668272
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.72396989
156TAF15_26573619_Chip-Seq_HEK293_Human0.71957609
157* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71870521
158ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.71368562
159PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71224657
160* CJUN_26792858_Chip-Seq_BT549_Human0.71147834
161AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.70877321
162PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.70476114
163GATA3_26560356_Chip-Seq_TH1_Human0.69563690
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.67962410
165FOXM1_26456572_ChIP-Seq_MCF-7_Human0.66086365
166* GATA1_19941826_ChIP-Seq_K562_Human0.65920464
167* GATA3_27048872_Chip-Seq_THYMUS_Human0.65002938
168* GATA2_19941826_ChIP-Seq_K562_Human0.64369159
169PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.63810140
170* SMAD4_21799915_ChIP-Seq_A2780_Human0.62355746
171TP53_18474530_ChIP-ChIP_U2OS_Human0.62156157
172VDR_24787735_ChIP-Seq_THP-1_Human0.60849112
173LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.60602687
174HOXB7_26014856_ChIP-Seq_BT474_Human0.60429914
175EZH2_22144423_ChIP-Seq_EOC_Human0.59045491
176P300_19829295_ChIP-Seq_ESCs_Human0.59017910
177* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.59016355
178ZNF217_24962896_ChIP-Seq_MCF-7_Human0.58842147
179SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.58463519
180NANOG_19829295_ChIP-Seq_ESCs_Human0.58048516
181SOX2_19829295_ChIP-Seq_ESCs_Human0.58048516
182PRDM14_20953172_ChIP-Seq_ESCs_Human0.58045776

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism4.80284127
2MP0000569_abnormal_digit_pigmentation4.70451069
3MP0003136_yellow_coat_color4.67239508
4MP0008961_abnormal_basal_metabolism3.74607175
5MP0002653_abnormal_ependyma_morphology3.59514867
6MP0001986_abnormal_taste_sensitivity3.16816250
7MP0005171_absent_coat_pigmentation3.16295832
8MP0006292_abnormal_olfactory_placode2.83627475
9MP0005646_abnormal_pituitary_gland2.82668697
10MP0009764_decreased_sensitivity_to2.76304220
11MP0004130_abnormal_muscle_cell2.63070713
12MP0003693_abnormal_embryo_hatching2.60792797
13MP0002638_abnormal_pupillary_reflex2.54162143
14MP0010386_abnormal_urinary_bladder2.50365642
15MP0006072_abnormal_retinal_apoptosis2.50060104
16MP0003252_abnormal_bile_duct2.48826056
17MP0005379_endocrine/exocrine_gland_phen2.46333510
18MP0000013_abnormal_adipose_tissue2.38937379
19MP0005083_abnormal_biliary_tract2.38379868
20MP0004264_abnormal_extraembryonic_tissu2.35945542
21MP0000371_diluted_coat_color2.22315502
22MP0008789_abnormal_olfactory_epithelium2.20810932
23MP0002938_white_spotting2.19790871
24MP0009379_abnormal_foot_pigmentation2.15486177
25MP0002160_abnormal_reproductive_system2.09079013
26MP0005645_abnormal_hypothalamus_physiol2.08335506
27MP0004133_heterotaxia2.05526049
28MP0001984_abnormal_olfaction1.98315452
29MP0001944_abnormal_pancreas_morphology1.98193784
30MP0001879_abnormal_lymphatic_vessel1.97215556
31MP0001188_hyperpigmentation1.93642279
32MP0000678_abnormal_parathyroid_gland1.91231563
33MP0008004_abnormal_stomach_pH1.88395631
34MP0008872_abnormal_physiological_respon1.88335753
35MP0004957_abnormal_blastocyst_morpholog1.75887135
36MP0000049_abnormal_middle_ear1.74670919
37MP0002138_abnormal_hepatobiliary_system1.72934720
38MP0002009_preneoplasia1.72924639
39MP0001800_abnormal_humoral_immune1.72272975
40MP0008058_abnormal_DNA_repair1.68852128
41MP0005389_reproductive_system_phenotype1.65991595
42MP0005394_taste/olfaction_phenotype1.65594937
43MP0005499_abnormal_olfactory_system1.65594937
44MP0002163_abnormal_gland_morphology1.59310937
45MP0002693_abnormal_pancreas_physiology1.58961668
46MP0008932_abnormal_embryonic_tissue1.56714147
47MP0000631_abnormal_neuroendocrine_gland1.56493349
48MP0005220_abnormal_exocrine_pancreas1.52329801
49MP0002877_abnormal_melanocyte_morpholog1.51613064
50MP0003123_paternal_imprinting1.49590868
51MP0003646_muscle_fatigue1.48530800
52MP0009697_abnormal_copulation1.46390038
53MP0000383_abnormal_hair_follicle1.45780907
54MP0003283_abnormal_digestive_organ1.45772368
55MP0003959_abnormal_lean_body1.45544294
56MP0010094_abnormal_chromosome_stability1.43276515
57MP0008057_abnormal_DNA_replication1.42491801
58MP0005253_abnormal_eye_physiology1.40133247
59MP0008007_abnormal_cellular_replicative1.39444395
60MP0004043_abnormal_pH_regulation1.39407667
61MP0002876_abnormal_thyroid_physiology1.38626646
62MP0001929_abnormal_gametogenesis1.34672479
63MP0000613_abnormal_salivary_gland1.32694479
64MP0003941_abnormal_skin_development1.30422016
65MP0008877_abnormal_DNA_methylation1.25015186
66MP0003786_premature_aging1.24624591
67MP0002075_abnormal_coat/hair_pigmentati1.24074611
68MP0002210_abnormal_sex_determination1.23929227
69MP0005551_abnormal_eye_electrophysiolog1.23044062
70MP0004134_abnormal_chest_morphology1.21733747
71MP0001919_abnormal_reproductive_system1.21061975
72MP0005448_abnormal_energy_balance1.19707250
73MP0001270_distended_abdomen1.18404027
74MP0003122_maternal_imprinting1.17837821
75MP0003077_abnormal_cell_cycle1.16492101
76MP0004782_abnormal_surfactant_physiolog1.13448327
77MP0002452_abnormal_antigen_presenting1.13214139
78MP0002249_abnormal_larynx_morphology1.11616315
79MP0002837_dystrophic_cardiac_calcinosis1.10587999
80MP0003698_abnormal_male_reproductive1.10325683
81MP0003121_genomic_imprinting1.08655278
82MP0002928_abnormal_bile_duct1.07889062
83MP0005671_abnormal_response_to1.07868126
84MP0003186_abnormal_redox_activity1.05161976
85MP0005275_abnormal_skin_tensile1.04991167
86MP0002282_abnormal_trachea_morphology1.02922680
87MP0002332_abnormal_exercise_endurance1.02594319
88MP0010030_abnormal_orbit_morphology1.01045969
89MP0002095_abnormal_skin_pigmentation1.00699255
90MP0000163_abnormal_cartilage_morphology0.99457066
91MP0000653_abnormal_sex_gland0.98548779
92MP0002132_abnormal_respiratory_system0.98280299
93MP0002751_abnormal_autonomic_nervous0.97961940
94MP0003937_abnormal_limbs/digits/tail_de0.97959525
95MP0003942_abnormal_urinary_system0.97419610
96MP0001145_abnormal_male_reproductive0.95640734
97MP0005334_abnormal_fat_pad0.95116397
98MP0002405_respiratory_system_inflammati0.94720365
99MP0003111_abnormal_nucleus_morphology0.92837179
100MP0009250_abnormal_appendicular_skeleto0.92627588
101MP0005410_abnormal_fertilization0.91936280
102MP0002723_abnormal_immune_serum0.91669592
103MP0002909_abnormal_adrenal_gland0.90583740
104MP0003718_maternal_effect0.90476046
105MP0001502_abnormal_circadian_rhythm0.90031209
106MP0002166_altered_tumor_susceptibility0.87999926
107MP0006036_abnormal_mitochondrial_physio0.87955550
108MP0002116_abnormal_craniofacial_bone0.87939020
109MP0000003_abnormal_adipose_tissue0.86917022
110MP0002234_abnormal_pharynx_morphology0.85793383
111MP0001485_abnormal_pinna_reflex0.84290187
112MP0000733_abnormal_muscle_development0.84088157
113MP0004142_abnormal_muscle_tone0.83894191
114MP0004381_abnormal_hair_follicle0.83176765
115MP0000685_abnormal_immune_system0.83093738
116MP0005075_abnormal_melanosome_morpholog0.82624351
117MP0001191_abnormal_skin_condition0.82511322
118MP0005000_abnormal_immune_tolerance0.82181758
119MP0000689_abnormal_spleen_morphology0.81679455
120MP0002722_abnormal_immune_system0.81259698
121MP0002177_abnormal_outer_ear0.81229999
122MP0002420_abnormal_adaptive_immunity0.80686597
123MP0005636_abnormal_mineral_homeostasis0.80423811
124MP0009384_cardiac_valve_regurgitation0.79255300
125MP0001905_abnormal_dopamine_level0.79197209
126MP0001286_abnormal_eye_development0.78824746
127MP0001819_abnormal_immune_cell0.78641524
128MP0000716_abnormal_immune_system0.78194796
129MP0005391_vision/eye_phenotype0.77450205
130MP0001542_abnormal_bone_strength0.77179103
131MP0003656_abnormal_erythrocyte_physiolo0.77029577
132MP0002006_tumorigenesis0.76086731
133MP0005076_abnormal_cell_differentiation0.75980202
134MP0002932_abnormal_joint_morphology0.75831667
135MP0000026_abnormal_inner_ear0.75828328
136MP0006276_abnormal_autonomic_nervous0.75377791
137MP0004885_abnormal_endolymph0.75364624
138MP0005174_abnormal_tail_pigmentation0.74709631
139MP0000566_synostosis0.74604164
140MP0003828_pulmonary_edema0.74410530
141MP0002233_abnormal_nose_morphology0.73784209
142MP0003195_calcinosis0.73640244
143MP0005408_hypopigmentation0.73277524
144MP0002277_abnormal_respiratory_mucosa0.73247131
145MP0000538_abnormal_urinary_bladder0.72349735
146MP0003315_abnormal_perineum_morphology0.72180685
147MP0005084_abnormal_gallbladder_morpholo0.71815531
148MP0002089_abnormal_postnatal_growth/wei0.71517388
149MP0001765_abnormal_ion_homeostasis0.70419457
150MP0000428_abnormal_craniofacial_morphol0.70372830
151MP0008770_decreased_survivor_rate0.69625459
152MP0002398_abnormal_bone_marrow0.68754802
153MP0000372_irregular_coat_pigmentation0.68680633
154MP0001529_abnormal_vocalization0.68509369
155MP0003279_aneurysm0.68446345
156MP0002295_abnormal_pulmonary_circulatio0.67984345
157MP0001186_pigmentation_phenotype0.67420379
158MP0005388_respiratory_system_phenotype0.66700316
159MP0002133_abnormal_respiratory_system0.66700316
160MP0004484_altered_response_of0.66691181
161MP0009115_abnormal_fat_cell0.66484864
162MP0002136_abnormal_kidney_physiology0.66432901
163MP0002971_abnormal_brown_adipose0.66014968
164MP0003221_abnormal_cardiomyocyte_apopto0.65267542
165MP0000470_abnormal_stomach_morphology0.65105748
166MP0003763_abnormal_thymus_physiology0.64493813
167MP0001835_abnormal_antigen_presentation0.62786376
168MP0001119_abnormal_female_reproductive0.62746574
169MP0000750_abnormal_muscle_regeneration0.62268264
170MP0010678_abnormal_skin_adnexa0.61483115
171MP0010368_abnormal_lymphatic_system0.61398091
172MP0002108_abnormal_muscle_morphology0.60439840

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.01978231
2Abnormal ciliary motility (HP:0012262)8.98769276
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.81194137
4Rhinitis (HP:0012384)7.95221328
5Oral leukoplakia (HP:0002745)7.14335767
6Abnormal respiratory motile cilium morphology (HP:0005938)6.79444821
7Abnormal respiratory epithelium morphology (HP:0012253)6.79444821
8Anomalous pulmonary venous return (HP:0010772)6.43440345
9Abnormality of the pulmonary veins (HP:0011718)5.72588313
10Chronic bronchitis (HP:0004469)5.46919864
11Pancreatic fibrosis (HP:0100732)5.24849785
12True hermaphroditism (HP:0010459)5.09399777
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.71577544
14Absent/shortened dynein arms (HP:0200106)4.71577544
15Deformed sella turcica (HP:0002681)4.66254237
16Bronchiectasis (HP:0002110)4.56221592
17Pancreatic cysts (HP:0001737)4.07742894
18Duplicated collecting system (HP:0000081)4.01509735
19Abnormality of the renal collecting system (HP:0004742)3.98682428
20Carpal bone hypoplasia (HP:0001498)3.97354947
21Short 4th metacarpal (HP:0010044)3.92262216
22Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.92262216
23Medial flaring of the eyebrow (HP:0010747)3.88715897
24Abnormality of midbrain morphology (HP:0002418)3.70894048
25Molar tooth sign on MRI (HP:0002419)3.70894048
26Abnormality of the odontoid process (HP:0003310)3.69817861
27Neoplasm of the heart (HP:0100544)3.67812098
28Vertebral fusion (HP:0002948)3.66096451
29Congenital primary aphakia (HP:0007707)3.62501663
30Short phalanx of the thumb (HP:0009660)3.60348573
31Abnormality of the sella turcica (HP:0002679)3.60276080
32Diastasis recti (HP:0001540)3.55991453
33Gait imbalance (HP:0002141)3.53714503
34Occipital encephalocele (HP:0002085)3.52255437
3511 pairs of ribs (HP:0000878)3.47012504
36Nephrogenic diabetes insipidus (HP:0009806)3.37079843
37Aortic regurgitation (HP:0001659)3.36805669
38Broad ribs (HP:0000885)3.36742422
39Nephronophthisis (HP:0000090)3.25529353
40Cystic liver disease (HP:0006706)3.22075702
41Abnormality of DNA repair (HP:0003254)3.20633869
42Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.17163055
43Slow saccadic eye movements (HP:0000514)3.13179518
44Chronic sinusitis (HP:0011109)3.09898199
45Median cleft lip (HP:0000161)3.08445327
46Tongue fasciculations (HP:0001308)3.07942586
47Hemiplegia (HP:0002301)3.02547760
48Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99499214
49J-shaped sella turcica (HP:0002680)2.97531234
50Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.95431520
51Abnormality of the parietal bone (HP:0002696)2.88588472
52Abnormality of the 4th metacarpal (HP:0010012)2.88363521
53Genital tract atresia (HP:0001827)2.82990288
54Acute necrotizing encephalopathy (HP:0006965)2.80464537
55Rough bone trabeculation (HP:0100670)2.79781801
56Genetic anticipation (HP:0003743)2.78935202
57Hemivertebrae (HP:0002937)2.76507745
58Aplasia/Hypoplasia of the tongue (HP:0010295)2.74090866
59Muscle fibrillation (HP:0010546)2.73166477
60Congenital hepatic fibrosis (HP:0002612)2.69813497
61Vaginal atresia (HP:0000148)2.69020016
62Premature graying of hair (HP:0002216)2.67055140
63Ectopic kidney (HP:0000086)2.61813857
64Abnormality of the pons (HP:0007361)2.59373426
65Postaxial foot polydactyly (HP:0001830)2.57820878
66Tubulointerstitial nephritis (HP:0001970)2.56922615
67Milia (HP:0001056)2.56095176
68Abnormal mitochondria in muscle tissue (HP:0008316)2.54596096
69Poor coordination (HP:0002370)2.53946050
70Bronchitis (HP:0012387)2.52488014
71Down-sloping shoulders (HP:0200021)2.51230231
72Hypoplasia of the pons (HP:0012110)2.51052748
73Vertebral arch anomaly (HP:0008438)2.48955270
74Preaxial hand polydactyly (HP:0001177)2.48946026
75Abnormality of the renal medulla (HP:0100957)2.48807486
76Chromsome breakage (HP:0040012)2.45995887
77Facial cleft (HP:0002006)2.44845382
78Amelogenesis imperfecta (HP:0000705)2.43073218
79Anencephaly (HP:0002323)2.42054371
80Short femoral neck (HP:0100864)2.41789580
81Abnormal sex determination (HP:0012244)2.38177220
82Sex reversal (HP:0012245)2.38177220
83Supernumerary spleens (HP:0009799)2.37078664
84Medulloblastoma (HP:0002885)2.37003484
85Bifid tongue (HP:0010297)2.36857782
86Abnormality of dentin (HP:0010299)2.36829138
87Mitochondrial inheritance (HP:0001427)2.36712064
88Impaired smooth pursuit (HP:0007772)2.35468824
89Skin pits (HP:0100276)2.31501974
90Thoracolumbar scoliosis (HP:0002944)2.30769610
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.30308146
92Abnormality of the intervertebral disk (HP:0005108)2.25574357
93Missing ribs (HP:0000921)2.24811527
94Abnormality of glycolipid metabolism (HP:0010969)2.24717065
95Abnormality of liposaccharide metabolism (HP:0010968)2.24717065
96Abnormality of glycosphingolipid metabolism (HP:0004343)2.24717065
97Progressive macrocephaly (HP:0004481)2.23991180
98Nasal polyposis (HP:0100582)2.22394701
99Sclerocornea (HP:0000647)2.22237060
100Prominent occiput (HP:0000269)2.21472094
101Abnormality of the preputium (HP:0100587)2.20369811
102Supernumerary bones of the axial skeleton (HP:0009144)2.17658258
103Male pseudohermaphroditism (HP:0000037)2.17324546
104Squamous cell carcinoma (HP:0002860)2.15794438
105Decreased circulating renin level (HP:0003351)2.15698392
106Polyuria (HP:0000103)2.14425085
107Postaxial hand polydactyly (HP:0001162)2.14117651
108Clubbing of toes (HP:0100760)2.10874926
109Supernumerary ribs (HP:0005815)2.10822048
110Neoplasm of the oral cavity (HP:0100649)2.09949899
111Abnormality of the lumbar spine (HP:0100712)2.09598132
112Abnormal trabecular bone morphology (HP:0100671)2.09590013
113Abnormality of cells of the erythroid lineage (HP:0012130)2.09396474
114Aplasia/Hypoplasia of the lens (HP:0008063)2.07979534
115Acute encephalopathy (HP:0006846)2.07979033
116Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.06006400
117Chronic hepatic failure (HP:0100626)2.06005255
118Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.05457035
119Decreased activity of mitochondrial respiratory chain (HP:0008972)2.05457035
120Clumsiness (HP:0002312)2.05319384
121Recurrent sinusitis (HP:0011108)2.03509928
122Hepatocellular necrosis (HP:0001404)2.02373369
123Abnormal number of erythroid precursors (HP:0012131)2.00935605
124Myelomeningocele (HP:0002475)2.00577762
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99530475
126Aplasia/hypoplasia of the uterus (HP:0008684)1.96069677
127Increased CSF lactate (HP:0002490)1.95998680
128Lip pit (HP:0100267)1.95322863
129Abnormal rod and cone electroretinograms (HP:0008323)1.94908786
130Wide intermamillary distance (HP:0006610)1.93470693
131Abnormality of chromosome stability (HP:0003220)1.92906284
132Hepatic necrosis (HP:0002605)1.92784874
133Oculomotor apraxia (HP:0000657)1.92101866
134Furrowed tongue (HP:0000221)1.90723821
135Short thumb (HP:0009778)1.90314520
136Abnormality of the distal phalanx of the thumb (HP:0009617)1.90090643
137Sparse lateral eyebrow (HP:0005338)1.89627492
138Infertility (HP:0000789)1.88632109
139Abnormality of pyrimidine metabolism (HP:0004353)1.88176723
140Esophageal neoplasm (HP:0100751)1.87437324
141Neoplasm of head and neck (HP:0012288)1.87437324
142Abnormality of the carotid arteries (HP:0005344)1.87262420
143Flared iliac wings (HP:0002869)1.86378766
144Broad foot (HP:0001769)1.84769482
145Exercise intolerance (HP:0003546)1.84711165
146Ureteral duplication (HP:0000073)1.83557310
147Small hand (HP:0200055)1.83280721
148Abnormality of the proximal phalanges of the hand (HP:0009834)1.83042462
149Concave nail (HP:0001598)1.82728713
150Aganglionic megacolon (HP:0002251)1.82389828
151Flat acetabular roof (HP:0003180)1.82265741
152Bony spicule pigmentary retinopathy (HP:0007737)1.81364222
153Overgrowth (HP:0001548)1.81116926
154Absent rod-and cone-mediated responses on ERG (HP:0007688)1.80573031
155Abnormality of the ileum (HP:0001549)1.80486903
156Thickened calvaria (HP:0002684)1.80180215
157Abnormality of ocular smooth pursuit (HP:0000617)1.80136214
158Bone marrow hypocellularity (HP:0005528)1.79655328
159Pathologic fracture (HP:0002756)1.79649162
160Increased hepatocellular lipid droplets (HP:0006565)1.78769788
161Death in childhood (HP:0003819)1.77722415
162Meckel diverticulum (HP:0002245)1.77489885
163Recurrent bronchitis (HP:0002837)1.77008751
164Fibular aplasia (HP:0002990)1.76980660
165Retinitis pigmentosa (HP:0000510)1.76546419
166Calf muscle hypertrophy (HP:0008981)1.75000148
167Abnormality of renal resorption (HP:0011038)1.73437831
168Decreased testicular size (HP:0008734)1.73254011
169Broad alveolar ridges (HP:0000187)1.72698804
170Cerebellar dysplasia (HP:0007033)1.71388357
171Congenital, generalized hypertrichosis (HP:0004540)1.70859321
172Type I transferrin isoform profile (HP:0003642)1.70803937
173Multicystic kidney dysplasia (HP:0000003)1.67240930
174Fibular hypoplasia (HP:0003038)1.67129961
175Abnormality of the dental pulp (HP:0006479)1.66562520
176Tubular atrophy (HP:0000092)1.64559282
177Abnormality of permanent molar morphology (HP:0011071)1.64420443
178Abnormality of the dental root (HP:0006486)1.64420443
179Taurodontia (HP:0000679)1.64420443
180Atelectasis (HP:0100750)1.61759242
181Symptomatic seizures (HP:0011145)1.61636626
182Hyperinsulinemic hypoglycemia (HP:0000825)1.58570872
183Abnormality of abdominal situs (HP:0011620)1.56044358
184Abdominal situs inversus (HP:0003363)1.56044358
185Recurrent otitis media (HP:0000403)1.56002488
186Secondary amenorrhea (HP:0000869)1.54527414
187Abnormal biliary tract physiology (HP:0012439)1.54399077
188Bile duct proliferation (HP:0001408)1.54399077
189Abnormality of the nasal mucosa (HP:0000433)1.54223964
190Hypoglycemic seizures (HP:0002173)1.53997294
191Abnormality of the fovea (HP:0000493)1.53395295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK8.51393385
2MAPK156.25062878
3VRK13.40290994
4STK163.26228184
5PASK2.95441222
6WEE12.93141492
7MAP3K42.84654903
8PNCK2.49525733
9FRK2.46603373
10MAP2K42.36877408
11TLK12.27606847
12SRPK12.11243038
13CDK82.10965183
14MST42.06616242
15BUB11.96968532
16CDC71.95559761
17BRSK21.93407671
18PLK41.91333376
19BRAF1.87204560
20PRKD31.79658040
21CDK121.74753201
22MAP2K31.72313500
23NME11.70122300
24DYRK31.66009805
25EIF2AK31.65861418
26CASK1.60366459
27INSRR1.59603746
28AURKA1.57399345
29TAOK31.52937807
30CDK31.37995480
31GRK11.36417095
32ERBB31.36117101
33CAMK1D1.34393852
34MAPKAPK31.33683964
35MKNK21.32866773
36MAP4K11.31320194
37ARAF1.29769652
38IRAK31.29322204
39IRAK11.24008387
40MKNK11.23296648
41DYRK21.20360466
42NEK91.19882459
43NEK11.16678460
44PLK31.14532720
45SGK21.12504026
46BMPR21.12237473
47SYK1.11113974
48TTK1.10138875
49CCNB11.09730925
50STK41.09108917
51BMPR1B1.08254497
52MUSK1.08082640
53HIPK21.07574469
54PIM21.06609415
55PRKCI1.06393570
56EIF2AK11.04880952
57PLK11.02955586
58WNK31.01985487
59PKN21.01772753
60STK38L1.00682569
61BRSK11.00104796
62AKT30.98317250
63PIM10.98152490
64AURKB0.96924449
65BRD40.96389604
66MAPK130.96377118
67ZAK0.95152934
68PIK3CG0.95105440
69RPS6KA40.92561890
70WNK40.92110436
71ADRBK20.91118041
72CAMK40.90480416
73PBK0.88210751
74DAPK30.88134022
75RPS6KA50.83746332
76TSSK60.82215246
77IKBKB0.80556305
78GRK70.79656340
79SGK2230.78739401
80SGK4940.78739401
81CHEK20.78676882
82TESK10.77453477
83ACVR1B0.77122081
84NEK20.77098017
85TGFBR20.75212319
86RPS6KB20.74988481
87MAP2K70.71542260
88TEC0.68899179
89RPS6KA60.68885325
90MAP2K60.68704806
91MAP3K60.68598087
92CAMK1G0.67989950
93MAPKAPK50.67730221
94CSNK2A10.66847498
95NME20.63357428
96STK30.63236974
97DAPK20.62330583
98STK240.62252211
99ATR0.61881336
100OBSCN0.61670410
101MAPK110.61209108
102PRKAA10.60777038
103GRK60.60729401
104TIE10.60670517
105PKN10.59404411
106SGK30.59129734
107LYN0.56739462
108RPS6KA20.55313995
109CDK70.53827638
110CSNK2A20.53033256
111CAMKK20.52702185
112MELK0.52650003
113MAP2K20.51678529
114RET0.51319520
115EPHA30.51289966
116TXK0.50984115
117YES10.50875814
118PTK2B0.50684636
119FGFR10.49718299
120PLK20.46970312
121MAP3K20.46676350
122EPHA20.46064841
123CAMKK10.45453119
124FLT30.44381093
125ADRBK10.43445866
126IKBKE0.43021157
127MAPK120.42742860
128ATM0.42733869
129GRK50.42609279
130PRKCG0.41126187
131BCR0.37617764
132WNK10.37364009
133CDK90.36013392
134MAPKAPK20.35390633
135CSNK1A1L0.34391932
136PRKACA0.33848000
137DAPK10.33042350
138PRKCE0.32757073
139DYRK1B0.32688745
140MAP3K30.32397343
141NEK60.31871102
142SCYL20.31436294
143RPS6KC10.31365604
144RPS6KL10.31365604
145TRPM70.31194573
146NTRK30.28669986
147NTRK20.28420584
148CDC42BPA0.28098639
149UHMK10.27821059
150PRKDC0.27333169
151CHEK10.26814237
152IRAK40.26029548
153PRKCH0.25507453
154CSK0.25232526
155MAP3K140.24924164
156PRKCQ0.21840456
157SGK10.20380337
158ERBB20.19736905
159MAPK70.18837590
160STK110.17707568
161PRKAA20.17507397
162CHUK0.16211568

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.07959148
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.69153164
3Ribosome_Homo sapiens_hsa030103.26738033
4DNA replication_Homo sapiens_hsa030303.17506720
5Oxidative phosphorylation_Homo sapiens_hsa001903.05189920
6Mismatch repair_Homo sapiens_hsa034303.03340631
7Huntingtons disease_Homo sapiens_hsa050162.80787727
8Proteasome_Homo sapiens_hsa030502.70852925
9RNA polymerase_Homo sapiens_hsa030202.69742434
10Homologous recombination_Homo sapiens_hsa034402.64556058
11Pyrimidine metabolism_Homo sapiens_hsa002402.61320295
12Nucleotide excision repair_Homo sapiens_hsa034202.57541136
13Parkinsons disease_Homo sapiens_hsa050122.49325995
14Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.38447493
15Basal transcription factors_Homo sapiens_hsa030222.08909505
16Spliceosome_Homo sapiens_hsa030402.00603381
17Phototransduction_Homo sapiens_hsa047441.95127651
18Base excision repair_Homo sapiens_hsa034101.91174653
19Ovarian steroidogenesis_Homo sapiens_hsa049131.90593227
20Purine metabolism_Homo sapiens_hsa002301.82741369
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.82689118
22Alzheimers disease_Homo sapiens_hsa050101.79493855
23Pancreatic secretion_Homo sapiens_hsa049721.75611559
24RNA degradation_Homo sapiens_hsa030181.68574443
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.60220087
26Fanconi anemia pathway_Homo sapiens_hsa034601.59731511
27Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.57038640
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56451193
29Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.54650318
30Sulfur metabolism_Homo sapiens_hsa009201.50965718
31Cell cycle_Homo sapiens_hsa041101.50578468
32Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.47681781
33RNA transport_Homo sapiens_hsa030131.43050482
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.39899317
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.34932522
36Vibrio cholerae infection_Homo sapiens_hsa051101.34664611
37Non-homologous end-joining_Homo sapiens_hsa034501.32340557
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32014511
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31637793
40SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24534548
41Sulfur relay system_Homo sapiens_hsa041221.18181503
42N-Glycan biosynthesis_Homo sapiens_hsa005101.16266086
43Morphine addiction_Homo sapiens_hsa050321.14967079
44Arachidonic acid metabolism_Homo sapiens_hsa005901.14964725
45Dorso-ventral axis formation_Homo sapiens_hsa043201.14700775
46Salivary secretion_Homo sapiens_hsa049701.14238174
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09336164
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.09254537
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09151007
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08065557
51Insulin secretion_Homo sapiens_hsa049111.05434555
52Folate biosynthesis_Homo sapiens_hsa007901.01563503
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01154327
54Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.00330757
55Sphingolipid metabolism_Homo sapiens_hsa006000.97495285
56Collecting duct acid secretion_Homo sapiens_hsa049660.96929523
57Circadian rhythm_Homo sapiens_hsa047100.96821616
58Other glycan degradation_Homo sapiens_hsa005110.96387423
59GnRH signaling pathway_Homo sapiens_hsa049120.96304188
60Leishmaniasis_Homo sapiens_hsa051400.95436505
61Staphylococcus aureus infection_Homo sapiens_hsa051500.94756945
62Linoleic acid metabolism_Homo sapiens_hsa005910.93112615
63Calcium signaling pathway_Homo sapiens_hsa040200.90345887
64NF-kappa B signaling pathway_Homo sapiens_hsa040640.90198442
65Cholinergic synapse_Homo sapiens_hsa047250.88282561
66Platelet activation_Homo sapiens_hsa046110.86703901
67Gastric acid secretion_Homo sapiens_hsa049710.85215013
68NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85026263
69Glutamatergic synapse_Homo sapiens_hsa047240.81507103
70Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80932282
71Dilated cardiomyopathy_Homo sapiens_hsa054140.79198694
72Alcoholism_Homo sapiens_hsa050340.75718355
73Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.74876660
74TNF signaling pathway_Homo sapiens_hsa046680.73785083
75Fat digestion and absorption_Homo sapiens_hsa049750.72346045
76Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.69927641
77Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68240013
78Metabolic pathways_Homo sapiens_hsa011000.65655510
79alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65441438
80GABAergic synapse_Homo sapiens_hsa047270.65319797
81Osteoclast differentiation_Homo sapiens_hsa043800.65304625
82Glutathione metabolism_Homo sapiens_hsa004800.64165274
83Cardiac muscle contraction_Homo sapiens_hsa042600.63866506
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.63342677
85mRNA surveillance pathway_Homo sapiens_hsa030150.63277383
86Circadian entrainment_Homo sapiens_hsa047130.62979992
87One carbon pool by folate_Homo sapiens_hsa006700.62663029
88Tuberculosis_Homo sapiens_hsa051520.60586702
89Gap junction_Homo sapiens_hsa045400.59684048
90Galactose metabolism_Homo sapiens_hsa000520.59278904
91Aldosterone synthesis and secretion_Homo sapiens_hsa049250.58805390
92Oxytocin signaling pathway_Homo sapiens_hsa049210.57339448
93T cell receptor signaling pathway_Homo sapiens_hsa046600.57238450
94ABC transporters_Homo sapiens_hsa020100.57165732
95Regulation of autophagy_Homo sapiens_hsa041400.56671736
96Asthma_Homo sapiens_hsa053100.55836138
97Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55373444
98Bile secretion_Homo sapiens_hsa049760.55156172
99Type I diabetes mellitus_Homo sapiens_hsa049400.54936955
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54254510
101Cocaine addiction_Homo sapiens_hsa050300.54116868
102cAMP signaling pathway_Homo sapiens_hsa040240.53818007
103Nicotine addiction_Homo sapiens_hsa050330.52608871
104Amphetamine addiction_Homo sapiens_hsa050310.52602140
105Primary immunodeficiency_Homo sapiens_hsa053400.52141406
106Hedgehog signaling pathway_Homo sapiens_hsa043400.51792490
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50295899
108Epstein-Barr virus infection_Homo sapiens_hsa051690.49384691
109Ether lipid metabolism_Homo sapiens_hsa005650.49320948
110Renin secretion_Homo sapiens_hsa049240.49220508
111Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49019141
112MAPK signaling pathway_Homo sapiens_hsa040100.47705039
113Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47233323
114Taste transduction_Homo sapiens_hsa047420.46818158
115p53 signaling pathway_Homo sapiens_hsa041150.46357069
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.46170876
117B cell receptor signaling pathway_Homo sapiens_hsa046620.44831654
118Systemic lupus erythematosus_Homo sapiens_hsa053220.44477865
119Oocyte meiosis_Homo sapiens_hsa041140.43943997
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42893754
121Vitamin B6 metabolism_Homo sapiens_hsa007500.42842369
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42420010
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41474677
124FoxO signaling pathway_Homo sapiens_hsa040680.41331623
125Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40946756
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40900021
127Olfactory transduction_Homo sapiens_hsa047400.40418037
128Vitamin digestion and absorption_Homo sapiens_hsa049770.39943027
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.38717557
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37520071
131Rheumatoid arthritis_Homo sapiens_hsa053230.37310104
132Selenocompound metabolism_Homo sapiens_hsa004500.36479953
133Wnt signaling pathway_Homo sapiens_hsa043100.36274116
134Nitrogen metabolism_Homo sapiens_hsa009100.36272591
135Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35837898
136Basal cell carcinoma_Homo sapiens_hsa052170.35201126
137Influenza A_Homo sapiens_hsa051640.35047447
138Fructose and mannose metabolism_Homo sapiens_hsa000510.34514026
139Renin-angiotensin system_Homo sapiens_hsa046140.33964933
140Serotonergic synapse_Homo sapiens_hsa047260.32202733
141Chemokine signaling pathway_Homo sapiens_hsa040620.32106631
142Protein digestion and absorption_Homo sapiens_hsa049740.32029383
143Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30966423
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30713471
145Synaptic vesicle cycle_Homo sapiens_hsa047210.30260070
146Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.30038691
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29771792
148Melanoma_Homo sapiens_hsa052180.29538846
149Glycosaminoglycan degradation_Homo sapiens_hsa005310.27783999
150Pyruvate metabolism_Homo sapiens_hsa006200.26792623
151Thyroid hormone synthesis_Homo sapiens_hsa049180.20395242
152Viral carcinogenesis_Homo sapiens_hsa052030.20090110
153Antigen processing and presentation_Homo sapiens_hsa046120.19504337
154Glucagon signaling pathway_Homo sapiens_hsa049220.18979748
155HTLV-I infection_Homo sapiens_hsa051660.16703449
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16684459
157Dopaminergic synapse_Homo sapiens_hsa047280.14144521
158Phagosome_Homo sapiens_hsa041450.13914903
159Fatty acid elongation_Homo sapiens_hsa000620.12209835
160Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.11686455
161Lysosome_Homo sapiens_hsa041420.11070768
162Thyroid cancer_Homo sapiens_hsa052160.10881303
163TGF-beta signaling pathway_Homo sapiens_hsa043500.10395595
164Melanogenesis_Homo sapiens_hsa049160.09916592
165Drug metabolism - other enzymes_Homo sapiens_hsa009830.09789492
166Carbohydrate digestion and absorption_Homo sapiens_hsa049730.08495216
167Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.08469991
168Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.07914179

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