TMEM109

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)6.14564368
2muscle filament sliding (GO:0030049)6.14564368
3regulation of skeletal muscle contraction (GO:0014819)6.08485824
4actin-mediated cell contraction (GO:0070252)4.96416049
5sarcomere organization (GO:0045214)4.96032049
6plasma membrane repair (GO:0001778)4.75767797
7protein maturation by protein folding (GO:0022417)4.66523403
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.38125535
9tricarboxylic acid cycle (GO:0006099)4.25337479
10pinocytosis (GO:0006907)4.04469035
11skeletal muscle contraction (GO:0003009)3.90617816
12myofibril assembly (GO:0030239)3.83928430
13actin filament-based movement (GO:0030048)3.74976080
14cardiac myofibril assembly (GO:0055003)3.66904600
15sarcoplasmic reticulum calcium ion transport (GO:0070296)3.64002015
16regulation of sequestering of triglyceride (GO:0010889)3.54010333
17apoptotic cell clearance (GO:0043277)3.48199452
18membrane raft organization (GO:0031579)3.41993331
19negative regulation of erythrocyte differentiation (GO:0045647)3.37023248
20vascular endothelial growth factor signaling pathway (GO:0038084)3.33422892
21skeletal muscle adaptation (GO:0043501)3.31041376
22oxaloacetate metabolic process (GO:0006107)3.30843928
23carnitine shuttle (GO:0006853)3.29829610
24NADH metabolic process (GO:0006734)3.29699163
25actomyosin structure organization (GO:0031032)3.29133625
26COPI coating of Golgi vesicle (GO:0048205)3.25826613
27Golgi transport vesicle coating (GO:0048200)3.25826613
28protein localization to endosome (GO:0036010)3.25465559
29low-density lipoprotein particle clearance (GO:0034383)3.24355767
30UV protection (GO:0009650)3.22132757
31positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.21922843
32fatty acid transmembrane transport (GO:1902001)3.21405318
33regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.18757089
34cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.18536393
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.17731686
36valine metabolic process (GO:0006573)3.16636796
37pentose-phosphate shunt (GO:0006098)3.14829048
38NIK/NF-kappaB signaling (GO:0038061)3.14782980
39creatine metabolic process (GO:0006600)3.13991021
40fibril organization (GO:0097435)3.12813360
41negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.07173731
42skeletal muscle fiber development (GO:0048741)3.03165609
43extracellular fibril organization (GO:0043206)3.01429772
44tricarboxylic acid metabolic process (GO:0072350)3.00106250
45striated muscle contraction (GO:0006941)2.98323224
46regulation of fatty acid oxidation (GO:0046320)2.97741386
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.96141678
48negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.95831545
49regulation of mammary gland epithelial cell proliferation (GO:0033599)2.92275194
50pyrimidine ribonucleoside catabolic process (GO:0046133)2.90205769
51surfactant homeostasis (GO:0043129)2.89643601
52basement membrane organization (GO:0071711)2.88720850
53epithelial cell-cell adhesion (GO:0090136)2.87969915
54protein hydroxylation (GO:0018126)2.86523619
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86272047
56hyaluronan catabolic process (GO:0030214)2.86242942
57positive regulation of myotube differentiation (GO:0010831)2.84788337
58regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.84067488
59keratan sulfate catabolic process (GO:0042340)2.83350700
60glucose catabolic process (GO:0006007)2.83059095
61regulation of cholesterol storage (GO:0010885)2.82961772
62barbed-end actin filament capping (GO:0051016)2.81532240
63regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81500977
64proline biosynthetic process (GO:0006561)2.80548872
65protein heterotrimerization (GO:0070208)2.79600718
66lipid particle organization (GO:0034389)2.78992091
67regulation of tight junction assembly (GO:2000810)2.77861840
68regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.76788988
69DNA unwinding involved in DNA replication (GO:0006268)2.76352257
70cytidine deamination (GO:0009972)2.74791789
71cytidine metabolic process (GO:0046087)2.74791789
72cytidine catabolic process (GO:0006216)2.74791789
73cardiac muscle cell development (GO:0055013)2.74118919
74purine nucleotide salvage (GO:0032261)2.73563874
75regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.73324666
76heart trabecula formation (GO:0060347)2.71307569
77cardiac muscle contraction (GO:0060048)2.70519765
78regulation of relaxation of muscle (GO:1901077)2.68089750
792-oxoglutarate metabolic process (GO:0006103)2.67639989
80antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.67123275
81antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.67123275
82muscle contraction (GO:0006936)2.67017941
83skin morphogenesis (GO:0043589)2.66876396
84protein retention in ER lumen (GO:0006621)2.66739848
85biotin metabolic process (GO:0006768)2.65282275
86angiogenesis involved in wound healing (GO:0060055)2.63970211
87hemidesmosome assembly (GO:0031581)2.63951357
88response to muscle activity (GO:0014850)2.63543664
89fatty acid beta-oxidation (GO:0006635)2.63315092
90negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.63192356
91apoptotic process involved in morphogenesis (GO:0060561)2.62703081
92cardiac cell development (GO:0055006)2.62676230
93negative regulation of cell size (GO:0045792)2.62610052
94positive regulation of blood vessel endothelial cell migration (GO:0043536)2.62349729
95negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.61321047
96positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59487664
97regulation of integrin-mediated signaling pathway (GO:2001044)2.59300917
98antigen processing and presentation of endogenous antigen (GO:0019883)2.59196180
99mitotic nuclear envelope reassembly (GO:0007084)2.58188306
100nuclear envelope reassembly (GO:0031468)2.58188306
101endothelial cell chemotaxis (GO:0035767)2.57832993
102phagocytosis, recognition (GO:0006910)2.57774841
103endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.57661014
104negative regulation of potassium ion transmembrane transport (GO:1901380)2.56942236
105stress fiber assembly (GO:0043149)2.55796487
106lymph vessel development (GO:0001945)2.55228845
107cell-substrate junction assembly (GO:0007044)2.55071841
108modulation by symbiont of host cellular process (GO:0044068)2.54836154
109negative regulation of stress fiber assembly (GO:0051497)2.53947663
110focal adhesion assembly (GO:0048041)2.52183537
111cell-substrate adherens junction assembly (GO:0007045)2.52183537
112regulation of p38MAPK cascade (GO:1900744)2.52015061
113adherens junction assembly (GO:0034333)2.50094421
114cell migration involved in heart development (GO:0060973)2.48899855
115NADPH regeneration (GO:0006740)2.48842871
116cellular response to zinc ion (GO:0071294)2.47848234
117muscle system process (GO:0003012)2.47546626
118negative regulation of cardiac muscle tissue growth (GO:0055022)2.45851657
119negative regulation of heart growth (GO:0061117)2.45851657
120mitotic chromosome condensation (GO:0007076)2.45608800
121desmosome organization (GO:0002934)2.45370553
122glomerular visceral epithelial cell development (GO:0072015)2.45211460
123positive regulation of Cdc42 GTPase activity (GO:0043089)2.44623459
124glycogen biosynthetic process (GO:0005978)2.44420100
125glucan biosynthetic process (GO:0009250)2.44420100
126positive regulation of fatty acid oxidation (GO:0046321)2.43547383
127myotube cell development (GO:0014904)2.43309676
128activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.42952749
129negative regulation of nitric-oxide synthase activity (GO:0051001)2.42320891
130glomerular basement membrane development (GO:0032836)2.42143195
131peptidyl-proline hydroxylation (GO:0019511)2.41820788
132positive regulation of nuclease activity (GO:0032075)2.41643020
133heart process (GO:0003015)2.41625178
134heart contraction (GO:0060047)2.41625178
135regulation of superoxide anion generation (GO:0032928)2.41224593
136muscle fiber development (GO:0048747)2.40803277
137negative regulation of necroptotic process (GO:0060546)2.40226681
138regulation of extracellular matrix disassembly (GO:0010715)2.39664855
139regulation of early endosome to late endosome transport (GO:2000641)2.39025962
140vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.34068693
141response to laminar fluid shear stress (GO:0034616)2.33046085
142modulation by virus of host process (GO:0019054)2.32532267
143embryo implantation (GO:0007566)2.32246025
144regulation of type I interferon-mediated signaling pathway (GO:0060338)2.31989766
145regulation of metalloenzyme activity (GO:0048552)2.31635557
146regulation of necrotic cell death (GO:0010939)2.30939919
147atrioventricular valve morphogenesis (GO:0003181)2.30637553
148GDP-mannose metabolic process (GO:0019673)2.30345839
149antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.29452215
150positive regulation of endothelial cell apoptotic process (GO:2000353)2.29171857
151positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.26878013
152adhesion of symbiont to host (GO:0044406)2.26593410
153mature B cell differentiation involved in immune response (GO:0002313)2.26354519
154pyrimidine-containing compound salvage (GO:0008655)2.25383898
155pyrimidine nucleoside salvage (GO:0043097)2.25383898
156regulation of defense response to virus by virus (GO:0050690)2.23907907
1573-UTR-mediated mRNA stabilization (GO:0070935)2.23313811
158endoplasmic reticulum unfolded protein response (GO:0030968)2.21499331
159modulation by virus of host morphology or physiology (GO:0019048)2.21052532
160chaperone mediated protein folding requiring cofactor (GO:0051085)2.19732948
161negative regulation of homotypic cell-cell adhesion (GO:0034111)2.19615164
162maternal placenta development (GO:0001893)2.18789021
163regulation of apoptotic process involved in morphogenesis (GO:1902337)2.18482798
164response to progesterone (GO:0032570)2.17692853
165response to thyroid hormone (GO:0097066)2.17478481
166regulation of nuclease activity (GO:0032069)2.17009900
167virion attachment to host cell (GO:0019062)2.15694711
168adhesion of symbiont to host cell (GO:0044650)2.15694711
169regulation of glucose import in response to insulin stimulus (GO:2001273)2.15100420
170regulation of necroptotic process (GO:0060544)2.14765660
171positive regulation of odontogenesis (GO:0042482)2.14374454
172mannose metabolic process (GO:0006013)2.13242744
173cellular hyperosmotic response (GO:0071474)2.13225849
174cortical actin cytoskeleton organization (GO:0030866)2.12907925
175regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.07754406
176positive regulation of lamellipodium organization (GO:1902745)2.07680527

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.82908830
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.87045051
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.83253546
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.63522021
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.25092519
6CLOCK_20551151_ChIP-Seq_293T_Human3.02777680
7TRIM28_21343339_ChIP-Seq_HEK293_Human2.50651066
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.50057213
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.48287508
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.47035514
11E2F7_22180533_ChIP-Seq_HELA_Human2.28327990
12* ELK3_25401928_ChIP-Seq_HUVEC_Human2.18379527
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.16822560
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.16467989
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.00674148
16RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.98785839
17GATA1_22025678_ChIP-Seq_K562_Human1.97219668
18TBX20_22328084_ChIP-Seq_HEART_Mouse1.93836086
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.93836086
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.92843611
21LXR_22292898_ChIP-Seq_THP-1_Human1.91802458
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78720626
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.77726878
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72313006
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.72263345
26ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.71821839
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.70419129
28* RACK7_27058665_Chip-Seq_MCF-7_Human1.69046675
29DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.68501293
30MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65047066
31STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64358350
32CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.62853848
33PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61440437
34ESR2_21235772_ChIP-Seq_MCF-7_Human1.61410908
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.59725153
36P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59302422
37ATF3_27146783_Chip-Seq_COLON_Human1.58982417
38KDM2B_26808549_Chip-Seq_SUP-B15_Human1.56890787
39VDR_21846776_ChIP-Seq_THP-1_Human1.52385384
40STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.51418221
41* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.47729456
42TET1_21451524_ChIP-Seq_MESCs_Mouse1.46653537
43* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.44559111
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.44160116
45ZNF263_19887448_ChIP-Seq_K562_Human1.43422235
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42693300
47* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42600006
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.42372523
49* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34453941
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.34341775
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32701243
52GATA2_21666600_ChIP-Seq_HMVEC_Human1.32159869
53NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.32131731
54RUNX1_22412390_ChIP-Seq_EML_Mouse1.32005053
55SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31917724
56* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31531657
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.30678953
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.29925365
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29694937
60* MAF_26560356_Chip-Seq_TH1_Human1.29054059
61MYB_21317192_ChIP-Seq_ERMYB_Mouse1.28486330
62EGR1_19374776_ChIP-ChIP_THP-1_Human1.28316905
63* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.28267254
64SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27805762
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.26446439
66MYC_22102868_ChIP-Seq_BL_Human1.25840053
67TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25589498
68* MAF_26560356_Chip-Seq_TH2_Human1.24467039
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.23953010
70* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23453600
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22633114
72SPI1_23127762_ChIP-Seq_K562_Human1.22313137
73* SA1_27219007_Chip-Seq_ERYTHROID_Human1.22242458
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21776709
75* KDM2B_26808549_Chip-Seq_DND41_Human1.21408857
76STAT4_19710469_ChIP-ChIP_TH1__Mouse1.20378863
77HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20167100
78* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18056692
79* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.18017592
80CJUN_26792858_Chip-Seq_BT549_Human1.17338800
81KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16808072
82ZFX_18555785_ChIP-Seq_MESCs_Mouse1.16379351
83EP300_21415370_ChIP-Seq_HL-1_Mouse1.16117333
84MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15350918
85SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.13955044
86NCOR1_26117541_ChIP-Seq_K562_Human1.13857428
87FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.13571905
88ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.12775284
89PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11385025
90JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.11329781
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.11228325
92TCF7_22412390_ChIP-Seq_EML_Mouse1.10914139
93ELF1_17652178_ChIP-ChIP_JURKAT_Human1.10623527
94* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.10456539
95BCOR_27268052_Chip-Seq_Bcells_Human1.09893026
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.09754779
97* XRN2_22483619_ChIP-Seq_HELA_Human1.08411948
98VDR_24763502_ChIP-Seq_THP-1_Human1.08277733
99TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08196186
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07685512
101IRF8_27001747_Chip-Seq_BMDM_Mouse1.07637180
102* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07396141
103E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06258198
104PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05980072
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.05895860
106GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05621165
107STAT3_1855785_ChIP-Seq_MESCs_Mouse1.05260539
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04946768
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04623154
110TFEB_21752829_ChIP-Seq_HELA_Human1.03980582
111* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.03554596
112PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03488820
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.02966332
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02752125
115MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.02223092
116* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01399023
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.01291113
118SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01229105
119* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.01189599
120MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01113203
121P68_20966046_ChIP-Seq_HELA_Human1.01105933
122SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.01082616
123* BCL6_27268052_Chip-Seq_Bcells_Human1.00921438
124SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00771525
125THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00749281
126* CTCF_21964334_Chip-Seq_Bcells_Human1.00682102
127ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99299067
128* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99086983
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.97695841
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.97695841
131* ELF1_20517297_ChIP-Seq_JURKAT_Human0.96843810
132JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95893263
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95875894
134UTX_26944678_Chip-Seq_JUKART_Human0.95415258
135* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94884177
136* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93674270
137MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.92425056
138TP63_22573176_ChIP-Seq_HFKS_Human0.92117603
139SOX2_20726797_ChIP-Seq_SW620_Human0.91132210
140ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.90576473
141UBF1/2_26484160_Chip-Seq_HMECs_Human0.90534867
142SPI1_20517297_ChIP-Seq_HL60_Human0.89099319
143TP53_22127205_ChIP-Seq_IMR90_Human0.88928716
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.88838137

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000749_muscle_degeneration3.79461904
2MP0000751_myopathy3.70771931
3MP0008438_abnormal_cutaneous_collagen3.57655256
4MP0002837_dystrophic_cardiac_calcinosis3.17718513
5MP0003705_abnormal_hypodermis_morpholog3.13668932
6MP0003646_muscle_fatigue3.03257475
7MP0005275_abnormal_skin_tensile2.86313592
8MP0000750_abnormal_muscle_regeneration2.65024740
9MP0004084_abnormal_cardiac_muscle2.56540873
10MP0004036_abnormal_muscle_relaxation2.51660426
11MP0005451_abnormal_body_composition2.46591384
12MP0010368_abnormal_lymphatic_system2.42114868
13MP0003279_aneurysm2.33529101
14MP0004145_abnormal_muscle_electrophysio2.31332075
15MP0004130_abnormal_muscle_cell2.27651023
16MP0004087_abnormal_muscle_fiber2.25209010
17MP0002106_abnormal_muscle_physiology2.00096836
18MP0005670_abnormal_white_adipose1.98143186
19MP0005330_cardiomyopathy1.96821979
20MP0003566_abnormal_cell_adhesion1.95033552
21MP0000759_abnormal_skeletal_muscle1.93825545
22MP0000747_muscle_weakness1.93486493
23MP0004272_abnormal_basement_membrane1.85375535
24MP0002269_muscular_atrophy1.83830712
25MP0005620_abnormal_muscle_contractility1.82431000
26MP0000013_abnormal_adipose_tissue1.75569306
27MP0000343_altered_response_to1.74518183
28MP0006054_spinal_hemorrhage1.73747138
29MP0001879_abnormal_lymphatic_vessel1.72375351
30MP0005058_abnormal_lysosome_morphology1.70912508
31MP0005369_muscle_phenotype1.67471070
32MP0003828_pulmonary_edema1.67053446
33MP0008260_abnormal_autophagy1.66482678
34MP0005666_abnormal_adipose_tissue1.66271732
35MP0001958_emphysema1.66098071
36MP0004215_abnormal_myocardial_fiber1.65996442
37MP0004185_abnormal_adipocyte_glucose1.57330559
38MP0002972_abnormal_cardiac_muscle1.57049187
39MP0009333_abnormal_splenocyte_physiolog1.54131761
40MP0003191_abnormal_cellular_cholesterol1.52672826
41MP0009278_abnormal_bone_marrow1.52498344
42MP0004233_abnormal_muscle_weight1.47798071
43MP0001544_abnormal_cardiovascular_syste1.46757335
44MP0005385_cardiovascular_system_phenoty1.46757335
45MP0006138_congestive_heart_failure1.44885799
46MP0005464_abnormal_platelet_physiology1.44863942
47MP0000733_abnormal_muscle_development1.44188393
48MP0003303_peritoneal_inflammation1.43466759
49MP0010630_abnormal_cardiac_muscle1.39354115
50MP0002332_abnormal_exercise_endurance1.38414397
51MP0005375_adipose_tissue_phenotype1.34453156
52* MP0003763_abnormal_thymus_physiology1.34265302
53MP0005503_abnormal_tendon_morphology1.31138442
54MP0001849_ear_inflammation1.28856875
55MP0010234_abnormal_vibrissa_follicle1.28734789
56MP0009840_abnormal_foam_cell1.28396400
57MP0008775_abnormal_heart_ventricle1.23127351
58MP0005165_increased_susceptibility_to1.22424693
59MP0005025_abnormal_response_to1.19848179
60MP0005023_abnormal_wound_healing1.17827977
61MP0005000_abnormal_immune_tolerance1.14782359
62MP0000003_abnormal_adipose_tissue1.13824104
63MP0002108_abnormal_muscle_morphology1.13482723
64MP0003806_abnormal_nucleotide_metabolis1.11366533
65MP0000465_gastrointestinal_hemorrhage1.10577098
66MP0002419_abnormal_innate_immunity1.09673594
67MP0005501_abnormal_skin_physiology1.09442268
68MP0004858_abnormal_nervous_system1.09411641
69MP0003453_abnormal_keratinocyte_physiol1.09167892
70MP0003950_abnormal_plasma_membrane1.09048174
71MP0003724_increased_susceptibility_to1.06581036
72MP0001533_abnormal_skeleton_physiology1.05580669
73MP0000767_abnormal_smooth_muscle1.05165757
74MP0002148_abnormal_hypersensitivity_rea1.05115651
75MP0002971_abnormal_brown_adipose1.03648174
76MP0002166_altered_tumor_susceptibility1.02779204
77MP0004484_altered_response_of1.02587028
78MP0003172_abnormal_lysosome_physiology1.02557812
79MP0004510_myositis1.02536189
80MP0002396_abnormal_hematopoietic_system1.02229105
81MP0003300_gastrointestinal_ulcer1.01468271
82MP0003436_decreased_susceptibility_to1.01347574
83MP0000678_abnormal_parathyroid_gland1.00822584
84MP0000490_abnormal_crypts_of0.99904461
85MP0002060_abnormal_skin_morphology0.99538568
86MP0008961_abnormal_basal_metabolism0.99094969
87MP0001790_abnormal_immune_system0.97126217
88MP0005387_immune_system_phenotype0.97126217
89MP0001853_heart_inflammation0.95839114
90MP0002452_abnormal_antigen_presenting0.95803771
91MP0001348_abnormal_lacrimal_gland0.93399870
92* MP0002420_abnormal_adaptive_immunity0.92689338
93MP0002933_joint_inflammation0.92682906
94MP0002398_abnormal_bone_marrow0.92359622
95MP0005076_abnormal_cell_differentiation0.91760390
96MP0009384_cardiac_valve_regurgitation0.91736021
97* MP0001819_abnormal_immune_cell0.91463870
98MP0001873_stomach_inflammation0.91423015
99MP0005397_hematopoietic_system_phenotyp0.91336853
100MP0001545_abnormal_hematopoietic_system0.91336853
101MP0003221_abnormal_cardiomyocyte_apopto0.90219965
102MP0002723_abnormal_immune_serum0.89728278
103MP0010030_abnormal_orbit_morphology0.87098837
104MP0003448_altered_tumor_morphology0.86411538
105MP0002295_abnormal_pulmonary_circulatio0.86126663
106MP0002796_impaired_skin_barrier0.86078063
107MP0001851_eye_inflammation0.85819294
108MP0002429_abnormal_blood_cell0.85638932
109MP0002877_abnormal_melanocyte_morpholog0.84674236
110MP0001542_abnormal_bone_strength0.84564015
111MP0002405_respiratory_system_inflammati0.84094782
112MP0004808_abnormal_hematopoietic_stem0.83492538
113MP0009785_altered_susceptibility_to0.83095059
114MP0006036_abnormal_mitochondrial_physio0.82393150
115MP0002128_abnormal_blood_circulation0.82285628
116MP0002722_abnormal_immune_system0.81981862
117MP0001800_abnormal_humoral_immune0.81363302
118MP0003045_fibrosis0.79430178
119MP0001243_abnormal_dermal_layer0.77916203
120MP0001835_abnormal_antigen_presentation0.77703289
121MP0009115_abnormal_fat_cell0.75965453
122MP0000249_abnormal_blood_vessel0.75803573
123MP0005257_abnormal_intraocular_pressure0.74325106
124MP0002998_abnormal_bone_remodeling0.73334635
125MP0003091_abnormal_cell_migration0.72172084
126MP0000266_abnormal_heart_morphology0.71528284
127MP0005390_skeleton_phenotype0.69769395
128MP0001756_abnormal_urination0.69138054
129MP0000685_abnormal_immune_system0.68996496
130MP0002896_abnormal_bone_mineralization0.68824958
131MP0000858_altered_metastatic_potential0.68783155
132MP0004782_abnormal_surfactant_physiolog0.68125393
133MP0009643_abnormal_urine_homeostasis0.67772896
134MP0000230_abnormal_systemic_arterial0.66848553
135MP0003075_altered_response_to0.65680567
136MP0003137_abnormal_impulse_conducting0.65455198
137MP0010352_gastrointestinal_tract_polyps0.63248612
138MP0002127_abnormal_cardiovascular_syste0.62988535
139MP0005508_abnormal_skeleton_morphology0.62913622
140MP0009780_abnormal_chondrocyte_physiolo0.62486345
141MP0005334_abnormal_fat_pad0.62427260
142MP0001614_abnormal_blood_vessel0.59475187
143MP0004947_skin_inflammation0.58236233
144MP0005623_abnormal_meninges_morphology0.58219625

Predicted human phenotypes

RankGene SetZ-score
1Type 1 muscle fiber predominance (HP:0003803)5.45727744
2Exercise-induced muscle cramps (HP:0003710)5.25632287
3Exercise-induced myalgia (HP:0003738)5.20781120
4Increased connective tissue (HP:0009025)5.03062379
5Muscle fiber inclusion bodies (HP:0100299)4.92837952
6Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.89498499
7Muscle fiber splitting (HP:0003555)4.71629391
8Nemaline bodies (HP:0003798)4.33696240
9Myoglobinuria (HP:0002913)4.20790047
10Difficulty running (HP:0009046)4.05462944
11Distal arthrogryposis (HP:0005684)4.03807168
12Calf muscle hypertrophy (HP:0008981)3.89625939
13Muscle hypertrophy of the lower extremities (HP:0008968)3.81563868
14Hyporeflexia of lower limbs (HP:0002600)3.78879086
15Myopathic facies (HP:0002058)3.71362692
16Ulnar deviation of the wrist (HP:0003049)3.71272812
17Abnormality of skeletal muscle fiber size (HP:0012084)3.70861067
18Round ear (HP:0100830)3.69646890
19Increased variability in muscle fiber diameter (HP:0003557)3.55211711
20Asymmetric septal hypertrophy (HP:0001670)3.53432361
21Abnormality of the calf musculature (HP:0001430)3.52839613
22Protrusio acetabuli (HP:0003179)3.44808704
23EMG: myopathic abnormalities (HP:0003458)3.42142055
24Sudden death (HP:0001699)3.41270283
25Ventricular tachycardia (HP:0004756)3.40870300
26Rhabdomyolysis (HP:0003201)3.34214846
27Difficulty climbing stairs (HP:0003551)3.30344265
28Muscle stiffness (HP:0003552)3.22725639
29Right ventricular cardiomyopathy (HP:0011663)3.14852495
30Myotonia (HP:0002486)3.13857829
31Premature rupture of membranes (HP:0001788)3.00904071
32Calcaneovalgus deformity (HP:0001848)3.00784320
33Spinal rigidity (HP:0003306)2.99456053
34Mildly elevated creatine phosphokinase (HP:0008180)2.90983898
35Lipoatrophy (HP:0100578)2.78971793
36Deformed tarsal bones (HP:0008119)2.76835372
37Neck muscle weakness (HP:0000467)2.72039627
38Cerebral aneurysm (HP:0004944)2.69920559
39Distal lower limb muscle weakness (HP:0009053)2.66586256
40Abnormality of the left ventricular outflow tract (HP:0011103)2.64630548
41Subaortic stenosis (HP:0001682)2.64630548
42Ankle contracture (HP:0006466)2.63775410
43Slender build (HP:0001533)2.57481157
44Ragged-red muscle fibers (HP:0003200)2.57101313
45Limb-girdle muscle atrophy (HP:0003797)2.56855548
46Facial diplegia (HP:0001349)2.55244747
47Absent phalangeal crease (HP:0006109)2.51473506
48Frequent falls (HP:0002359)2.49360594
49Malignant hyperthermia (HP:0002047)2.45993467
50Trismus (HP:0000211)2.43593391
51Mesangial abnormality (HP:0001966)2.41586040
52Abnormality of liposaccharide metabolism (HP:0010968)2.40033775
53Abnormality of glycosphingolipid metabolism (HP:0004343)2.40033775
54Abnormality of glycolipid metabolism (HP:0010969)2.40033775
55Cellulitis (HP:0100658)2.33580753
56Osteolytic defects of the hand bones (HP:0009699)2.32488130
57Osteolytic defects of the phalanges of the hand (HP:0009771)2.32488130
58Fatigue (HP:0012378)2.29777244
59Broad metatarsal (HP:0001783)2.28952475
60Aortic aneurysm (HP:0004942)2.28412911
61Abnormality of the calcaneus (HP:0008364)2.27230642
62Scapular winging (HP:0003691)2.26907670
63Aortic dissection (HP:0002647)2.25700325
64Vertebral compression fractures (HP:0002953)2.25219046
65Dilated cardiomyopathy (HP:0001644)2.21701159
66Axonal loss (HP:0003447)2.21528719
67Nonimmune hydrops fetalis (HP:0001790)2.19958379
68Abnormality of the Achilles tendon (HP:0005109)2.17354741
69Hyperacusis (HP:0010780)2.16155885
70Generalized muscle weakness (HP:0003324)2.15522511
71Abnormality of the distal phalanges of the toes (HP:0010182)2.14216840
72Gowers sign (HP:0003391)2.14205947
73Conjunctival hamartoma (HP:0100780)2.13938935
74Progressive muscle weakness (HP:0003323)2.13760388
75Distal lower limb amyotrophy (HP:0008944)2.12186892
76Blue sclerae (HP:0000592)2.10918896
77Ketoacidosis (HP:0001993)2.10883301
78Systemic lupus erythematosus (HP:0002725)2.10399309
79Atrial fibrillation (HP:0005110)2.09957885
80Broad face (HP:0000283)2.08191854
81Polycythemia (HP:0001901)2.05375166
82Short nail (HP:0001799)2.05173306
83Hypertriglyceridemia (HP:0002155)2.04433382
84Reduced subcutaneous adipose tissue (HP:0003758)2.04147554
85J-shaped sella turcica (HP:0002680)2.03868052
86Fragile skin (HP:0001030)2.03213392
87Palpitations (HP:0001962)2.02805413
88Glucose intolerance (HP:0000833)2.02574468
89Interstitial pulmonary disease (HP:0006530)2.02132434
90Elbow flexion contracture (HP:0002987)1.99441977
91Cholecystitis (HP:0001082)1.98984395
92Abnormal gallbladder physiology (HP:0012438)1.98984395
93Generalized amyotrophy (HP:0003700)1.98507413
94Hypertensive crisis (HP:0100735)1.97967170
95Areflexia of lower limbs (HP:0002522)1.97847234
96Dilatation of the ascending aorta (HP:0005111)1.97256016
97Bulbar palsy (HP:0001283)1.96978318
98Testicular atrophy (HP:0000029)1.96377815
99Wormian bones (HP:0002645)1.95012649
100Abnormality of the neuromuscular junction (HP:0003398)1.93415969
101Fatigable weakness (HP:0003473)1.93415969
102Abnormality of macrophages (HP:0004311)1.92343514
103Primary atrial arrhythmia (HP:0001692)1.91234890
104Muscular dystrophy (HP:0003560)1.91026260
105Supraventricular arrhythmia (HP:0005115)1.89631214
106Increased cerebral lipofuscin (HP:0011813)1.88271362
107Esophageal neoplasm (HP:0100751)1.87927271
108Neoplasm of head and neck (HP:0012288)1.87927271
109Supraventricular tachycardia (HP:0004755)1.86689332
110Colitis (HP:0002583)1.86591419
111Distal upper limb amyotrophy (HP:0007149)1.86467327
112Upper limb amyotrophy (HP:0009129)1.86467327
113Biconcave vertebral bodies (HP:0004586)1.86197760
114Oligomenorrhea (HP:0000876)1.85566306
115Achilles tendon contracture (HP:0001771)1.85510364
116Increased serum ferritin (HP:0003281)1.85407088
117Dysostosis multiplex (HP:0000943)1.84501536
118Hepatosplenomegaly (HP:0001433)1.84091651
119Urinary glycosaminoglycan excretion (HP:0003541)1.82634198
120Mucopolysacchariduria (HP:0008155)1.82634198
121Easy fatigability (HP:0003388)1.82159157
122Abnormal finger flexion creases (HP:0006143)1.81266769
123Increased density of long bones (HP:0006392)1.81154990
124Peritonitis (HP:0002586)1.80389104
125Back pain (HP:0003418)1.79804477
126Abnormality of mucopolysaccharide metabolism (HP:0011020)1.77796732
127Abnormality of polysaccharide metabolism (HP:0011012)1.77796732
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.77796732
129Mitral regurgitation (HP:0001653)1.75730253
130Nuclear cataract (HP:0100018)1.75570503
131Abnormality of the umbilical cord (HP:0010881)1.75279301
132Stridor (HP:0010307)1.75107399
133Growth hormone excess (HP:0000845)1.74738526
134EMG: neuropathic changes (HP:0003445)1.74530063
135Joint stiffness (HP:0001387)1.74334259
136Aneurysm (HP:0002617)1.73939527
137Gastrointestinal dysmotility (HP:0002579)1.73890294
138Shallow orbits (HP:0000586)1.73781030
139Atrophic scars (HP:0001075)1.72739463
140Amyloidosis (HP:0011034)1.71703353
141Acanthosis nigricans (HP:0000956)1.70893426
142Bladder diverticulum (HP:0000015)1.70489782
143Cervical subluxation (HP:0003308)1.70076770
144Hypoglycemic coma (HP:0001325)1.69912602
145Myocardial infarction (HP:0001658)1.69251352
146Hemorrhage of the eye (HP:0011885)1.68516887
147Limb-girdle muscle weakness (HP:0003325)1.68330923
148Emphysema (HP:0002097)1.67698490
149Centrally nucleated skeletal muscle fibers (HP:0003687)1.67627883
150Long toe (HP:0010511)1.67080245
151Rough bone trabeculation (HP:0100670)1.66770551
152Gastrointestinal inflammation (HP:0004386)1.66490702
153Increased neuronal autofluorescent lipopigment (HP:0002074)1.66217774
154Follicular hyperkeratosis (HP:0007502)1.65799580
155Increased IgE level (HP:0003212)1.65611018
156Eczematoid dermatitis (HP:0000976)1.64521952
157Loss of speech (HP:0002371)1.64504951
158Abnormality of the nasal mucosa (HP:0000433)1.64435474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.09307827
2TRIB34.77834870
3ERN13.68752490
4SMG12.89140733
5OBSCN2.82017815
6TESK22.78654631
7TGFBR22.76507939
8PRPF4B2.66708602
9TIE12.48639479
10PHKG22.37686452
11PHKG12.37686452
12PKN22.33945348
13BCKDK2.31003981
14MAP2K32.12403941
15EPHA22.11382976
16MYLK2.11325801
17KDR2.08865041
18ARAF1.95176018
19PIK3CG1.85488339
20ICK1.84209906
21VRK21.81844495
22SCYL21.80094214
23MOS1.76857210
24DMPK1.73936680
25NEK91.73598954
26TAOK21.64546866
27NEK11.64133613
28LRRK21.59848119
29MAP3K31.49659936
30STK101.49380275
31RIPK11.45687378
32TBK11.44262071
33SIK11.35773550
34PDK41.32711817
35PDK31.32711817
36PIM21.31010444
37MAP3K131.30534494
38CDK121.29432221
39PDK21.28062580
40ILK1.25432305
41PDGFRA1.21696501
42PTK61.17604460
43ZAP701.17214614
44LMTK21.12212023
45TRPM71.10714751
46EPHB11.09315087
47RPS6KA41.09275836
48MST1R1.04886718
49MAPKAPK31.04560753
50FGFR40.99415733
51PAK40.98259553
52EPHA30.98070553
53MAPK120.97299252
54PTK2B0.96223019
55NME20.95914063
56EPHB20.91625042
57STK240.90825145
58TYK20.87074284
59MAP3K110.83127193
60MAP3K140.82112704
61NME10.82002605
62MAP3K70.80711994
63CDC42BPA0.80287521
64JAK30.79281848
65CDK70.79119658
66TGFBR10.78025583
67BLK0.77592172
68KIT0.77284057
69BMX0.76973084
70FER0.76692725
71EEF2K0.76177772
72PRKD20.76076776
73CDK80.74519574
74PIK3CA0.72795546
75MAP3K100.71598435
76RPS6KB20.70510023
77MAP2K10.68169049
78TESK10.67564441
79LATS20.65985730
80JAK10.65817842
81BUB10.65760128
82TAOK10.64431165
83ROCK10.64161420
84MAP4K10.63971707
85CDK40.62991655
86AURKA0.62682240
87CLK10.62523817
88PRKD10.62367436
89IRAK40.62350456
90PAK20.61921771
91BRAF0.61905084
92MTOR0.61617236
93DDR20.61418606
94PTK20.60773528
95MAPKAPK20.59367601
96PAK10.57448557
97PDPK10.57308974
98FLT30.56243192
99DAPK10.53811807
100CSF1R0.51357736
101MAP3K10.50883427
102GRK60.49314955
103KSR20.49117750
104MAPK70.48967132
105JAK20.48493829
106MAP2K20.48433298
107MET0.47724714
108DAPK30.45625642
109MUSK0.45150210
110MAP3K60.44526509
111IRAK30.43136247
112PRKG20.42704331
113MAP3K80.42295769
114RET0.41437475
115GRK70.40738453
116RIPK40.40591972
117IKBKE0.40279580
118MAPK110.40265326
119CAMK1D0.40021394
120CDK90.37819027
121MAP3K50.37577530
122PRKCH0.34936858
123BTK0.34783170
124CCNB10.34239211
125SIK30.34218258
126MATK0.32988379
127ABL20.32941992
128CSK0.31008982
129LIMK10.30931600
130RPS6KA60.30744132
131RPS6KL10.29090927
132RPS6KC10.29090927
133PDGFRB0.28825095
134ITK0.28388198
135AKT20.26706151
136HIPK20.25993505
137STK38L0.25418134
138CAMKK20.25277402
139PINK10.25193862
140FGFR30.24897509

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.28971458
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.78451976
3Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.76051650
4Dilated cardiomyopathy_Homo sapiens_hsa054142.50315856
5Propanoate metabolism_Homo sapiens_hsa006402.40731409
6Fatty acid degradation_Homo sapiens_hsa000712.28587863
7DNA replication_Homo sapiens_hsa030302.26676048
8Carbon metabolism_Homo sapiens_hsa012002.20966081
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.04838601
10Fatty acid metabolism_Homo sapiens_hsa012121.95641040
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.86400027
12Sulfur relay system_Homo sapiens_hsa041221.82490785
13Lysosome_Homo sapiens_hsa041421.82030857
14Focal adhesion_Homo sapiens_hsa045101.76957577
15Viral myocarditis_Homo sapiens_hsa054161.75672294
16Other glycan degradation_Homo sapiens_hsa005111.65247272
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.64308276
18ECM-receptor interaction_Homo sapiens_hsa045121.62647626
19Adipocytokine signaling pathway_Homo sapiens_hsa049201.56664924
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52459808
21Insulin resistance_Homo sapiens_hsa049311.51798813
22Base excision repair_Homo sapiens_hsa034101.51317721
23Cyanoamino acid metabolism_Homo sapiens_hsa004601.50280095
24PPAR signaling pathway_Homo sapiens_hsa033201.50244603
25Cardiac muscle contraction_Homo sapiens_hsa042601.41589316
26Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.35540934
27B cell receptor signaling pathway_Homo sapiens_hsa046621.32574027
28Pyruvate metabolism_Homo sapiens_hsa006201.29978595
29Starch and sucrose metabolism_Homo sapiens_hsa005001.28638408
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.23822995
31Galactose metabolism_Homo sapiens_hsa000521.23136336
32N-Glycan biosynthesis_Homo sapiens_hsa005101.22746597
33Prion diseases_Homo sapiens_hsa050201.22309132
34Biosynthesis of amino acids_Homo sapiens_hsa012301.21331495
35Amoebiasis_Homo sapiens_hsa051461.20830925
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.18307613
37Leishmaniasis_Homo sapiens_hsa051401.18203213
38Non-small cell lung cancer_Homo sapiens_hsa052231.15317183
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12678352
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.10943978
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.10860795
42Herpes simplex infection_Homo sapiens_hsa051681.10720252
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09359435
44Legionellosis_Homo sapiens_hsa051341.08597828
45Primary immunodeficiency_Homo sapiens_hsa053401.08312696
46Hepatitis B_Homo sapiens_hsa051611.07109495
47Influenza A_Homo sapiens_hsa051641.06891134
48Adherens junction_Homo sapiens_hsa045201.05151778
49Malaria_Homo sapiens_hsa051441.04563425
50Insulin signaling pathway_Homo sapiens_hsa049101.04163532
51Toxoplasmosis_Homo sapiens_hsa051451.02454606
52Allograft rejection_Homo sapiens_hsa053301.00857165
53RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.00242206
54Proteoglycans in cancer_Homo sapiens_hsa052050.99415126
55Pertussis_Homo sapiens_hsa051330.99308985
56Vibrio cholerae infection_Homo sapiens_hsa051100.97796992
57Protein digestion and absorption_Homo sapiens_hsa049740.96025424
58Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.93437442
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93211622
60Staphylococcus aureus infection_Homo sapiens_hsa051500.92747090
61Proteasome_Homo sapiens_hsa030500.91012083
62HIF-1 signaling pathway_Homo sapiens_hsa040660.90793072
63Autoimmune thyroid disease_Homo sapiens_hsa053200.90183709
64Graft-versus-host disease_Homo sapiens_hsa053320.89470085
65Pyrimidine metabolism_Homo sapiens_hsa002400.88757128
66Phagosome_Homo sapiens_hsa041450.88552758
67Measles_Homo sapiens_hsa051620.87900308
68Small cell lung cancer_Homo sapiens_hsa052220.87260611
69Epstein-Barr virus infection_Homo sapiens_hsa051690.87057148
70Fructose and mannose metabolism_Homo sapiens_hsa000510.87018686
71Viral carcinogenesis_Homo sapiens_hsa052030.86038150
72Hepatitis C_Homo sapiens_hsa051600.84908799
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.84330273
74Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.81963776
75AMPK signaling pathway_Homo sapiens_hsa041520.80302369
76Endocytosis_Homo sapiens_hsa041440.79126433
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78439365
78Osteoclast differentiation_Homo sapiens_hsa043800.76125466
79Central carbon metabolism in cancer_Homo sapiens_hsa052300.75141858
80Antigen processing and presentation_Homo sapiens_hsa046120.74984979
81Glucagon signaling pathway_Homo sapiens_hsa049220.74963894
82Apoptosis_Homo sapiens_hsa042100.71835512
83Bladder cancer_Homo sapiens_hsa052190.71293085
84Platelet activation_Homo sapiens_hsa046110.70707253
85Pentose phosphate pathway_Homo sapiens_hsa000300.69904556
86VEGF signaling pathway_Homo sapiens_hsa043700.69710656
87beta-Alanine metabolism_Homo sapiens_hsa004100.68552124
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.68376567
89Shigellosis_Homo sapiens_hsa051310.67833026
90Fatty acid elongation_Homo sapiens_hsa000620.67611489
91Fatty acid biosynthesis_Homo sapiens_hsa000610.66639280
92Tuberculosis_Homo sapiens_hsa051520.66558853
93Parkinsons disease_Homo sapiens_hsa050120.64725488
94Salmonella infection_Homo sapiens_hsa051320.63082540
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61328241
96Folate biosynthesis_Homo sapiens_hsa007900.60656792
97Oxidative phosphorylation_Homo sapiens_hsa001900.59619255
98Hematopoietic cell lineage_Homo sapiens_hsa046400.58169444
99Renal cell carcinoma_Homo sapiens_hsa052110.57895354
100Caffeine metabolism_Homo sapiens_hsa002320.57886087
101Alzheimers disease_Homo sapiens_hsa050100.56903373
102Nucleotide excision repair_Homo sapiens_hsa034200.55939021
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55540748
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55340636
105Chronic myeloid leukemia_Homo sapiens_hsa052200.54995142
106Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53848790
107Acute myeloid leukemia_Homo sapiens_hsa052210.52810749
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52630935
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52407606
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49941412
111Notch signaling pathway_Homo sapiens_hsa043300.48820483
112Pancreatic cancer_Homo sapiens_hsa052120.48688461
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.48405265
114Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47953934
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.46935093
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46757780
117Arginine and proline metabolism_Homo sapiens_hsa003300.46465114
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46269675
119TNF signaling pathway_Homo sapiens_hsa046680.46204705
120Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46176775
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45187051
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41742170
123Circadian rhythm_Homo sapiens_hsa047100.41305265
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40385418
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39390683
126Glutathione metabolism_Homo sapiens_hsa004800.38849972
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38222513
128Tryptophan metabolism_Homo sapiens_hsa003800.36185907
129HTLV-I infection_Homo sapiens_hsa051660.35587497
130Renin-angiotensin system_Homo sapiens_hsa046140.35570277
131Thyroid cancer_Homo sapiens_hsa052160.34106697
132Tight junction_Homo sapiens_hsa045300.31494917
133Phenylalanine metabolism_Homo sapiens_hsa003600.30293560
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.29742215
135Protein export_Homo sapiens_hsa030600.29480568

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