

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | ribosomal small subunit assembly (GO:0000028) | 5.56590210 |
| 2 | chaperone-mediated protein transport (GO:0072321) | 5.48331323 |
| 3 | DNA deamination (GO:0045006) | 5.41011481 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.91158483 |
| 5 | maturation of SSU-rRNA (GO:0030490) | 4.85667868 |
| 6 | respiratory electron transport chain (GO:0022904) | 4.73584451 |
| 7 | ribosomal small subunit biogenesis (GO:0042274) | 4.66555173 |
| 8 | electron transport chain (GO:0022900) | 4.63810240 |
| 9 | viral transcription (GO:0019083) | 4.60783399 |
| 10 | protein complex biogenesis (GO:0070271) | 4.56890745 |
| 11 | proteasome assembly (GO:0043248) | 4.56671278 |
| 12 | translational termination (GO:0006415) | 4.54585335 |
| 13 | formation of translation preinitiation complex (GO:0001731) | 4.52704273 |
| 14 | ribosomal large subunit biogenesis (GO:0042273) | 4.42678208 |
| 15 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.33099544 |
| 16 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.32576800 |
| 17 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.32576800 |
| 18 | NADH dehydrogenase complex assembly (GO:0010257) | 4.32576800 |
| 19 | purine nucleobase biosynthetic process (GO:0009113) | 4.21400774 |
| 20 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.21135068 |
| 21 | nucleobase biosynthetic process (GO:0046112) | 4.20988475 |
| 22 | translational elongation (GO:0006414) | 4.20017700 |
| 23 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 4.05486330 |
| 24 | ribosome biogenesis (GO:0042254) | 4.05419483 |
| 25 | rRNA modification (GO:0000154) | 4.05099931 |
| 26 | protein neddylation (GO:0045116) | 4.04514487 |
| 27 | protein targeting to mitochondrion (GO:0006626) | 4.02964024 |
| 28 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.01048909 |
| 29 | protein targeting to ER (GO:0045047) | 4.01003797 |
| 30 | translational initiation (GO:0006413) | 4.00712170 |
| 31 | cotranslational protein targeting to membrane (GO:0006613) | 3.94437042 |
| 32 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.94097949 |
| 33 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.92402712 |
| 34 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.88138524 |
| 35 | termination of RNA polymerase III transcription (GO:0006386) | 3.88138524 |
| 36 | DNA strand elongation (GO:0022616) | 3.85543067 |
| 37 | rRNA processing (GO:0006364) | 3.80161641 |
| 38 | protein localization to endoplasmic reticulum (GO:0070972) | 3.79613904 |
| 39 | ribosome assembly (GO:0042255) | 3.77836453 |
| 40 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.77221166 |
| 41 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.76647558 |
| 42 | DNA damage response, detection of DNA damage (GO:0042769) | 3.74492418 |
| 43 | establishment of protein localization to mitochondrion (GO:0072655) | 3.74246810 |
| 44 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.74106510 |
| 45 | translation (GO:0006412) | 3.72982929 |
| 46 | DNA replication initiation (GO:0006270) | 3.72019544 |
| 47 | protein localization to mitochondrion (GO:0070585) | 3.71855547 |
| 48 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.71451113 |
| 49 | viral life cycle (GO:0019058) | 3.70954730 |
| 50 | DNA replication checkpoint (GO:0000076) | 3.68972790 |
| 51 | pseudouridine synthesis (GO:0001522) | 3.68605020 |
| 52 | rRNA metabolic process (GO:0016072) | 3.66771817 |
| 53 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.65539103 |
| 54 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.64944996 |
| 55 | spliceosomal snRNP assembly (GO:0000387) | 3.63286215 |
| 56 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 3.61266970 |
| 57 | negative regulation of ligase activity (GO:0051352) | 3.60796087 |
| 58 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.60796087 |
| 59 | protein deneddylation (GO:0000338) | 3.57121154 |
| 60 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.56403964 |
| 61 | respiratory chain complex IV assembly (GO:0008535) | 3.56213191 |
| 62 | cellular component biogenesis (GO:0044085) | 3.55241521 |
| 63 | oxidative phosphorylation (GO:0006119) | 3.54404782 |
| 64 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.53360710 |
| 65 | cellular protein complex disassembly (GO:0043624) | 3.52251255 |
| 66 | chromatin remodeling at centromere (GO:0031055) | 3.51249555 |
| 67 | cullin deneddylation (GO:0010388) | 3.51151338 |
| 68 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.51089609 |
| 69 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.51089609 |
| 70 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.50718933 |
| 71 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.50209869 |
| 72 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.50209869 |
| 73 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.50209869 |
| 74 | CENP-A containing nucleosome assembly (GO:0034080) | 3.48766619 |
| 75 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.48423969 |
| 76 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.48391050 |
| 77 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.45665113 |
| 78 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.45665113 |
| 79 | telomere maintenance via recombination (GO:0000722) | 3.45005961 |
| 80 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.42991485 |
| 81 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.42991485 |
| 82 | cytochrome complex assembly (GO:0017004) | 3.40634923 |
| 83 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.36943354 |
| 84 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.36263534 |
| 85 | IMP biosynthetic process (GO:0006188) | 3.35387890 |
| 86 | inner mitochondrial membrane organization (GO:0007007) | 3.35323107 |
| 87 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.34928173 |
| 88 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.29044736 |
| 89 | regulation of mitochondrial translation (GO:0070129) | 3.28834752 |
| 90 | 7-methylguanosine mRNA capping (GO:0006370) | 3.24957882 |
| 91 | regulation of ligase activity (GO:0051340) | 3.24564413 |
| 92 | ubiquinone biosynthetic process (GO:0006744) | 3.23340200 |
| 93 | rRNA methylation (GO:0031167) | 3.22375466 |
| 94 | mitotic metaphase plate congression (GO:0007080) | 3.21728352 |
| 95 | positive regulation of ligase activity (GO:0051351) | 3.20158458 |
| 96 | ATP synthesis coupled proton transport (GO:0015986) | 3.19813899 |
| 97 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.19813899 |
| 98 | pyrimidine deoxyribonucleotide metabolic process (GO:0009219) | 3.19697235 |
| 99 | DNA damage response, signal transduction by p53 class mediator (GO:0030330) | 3.19628755 |
| 100 | mitotic recombination (GO:0006312) | 3.19028976 |
| 101 | base-excision repair, AP site formation (GO:0006285) | 3.18137562 |
| 102 | cell cycle G1/S phase transition (GO:0044843) | 3.18041399 |
| 103 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.18041399 |
| 104 | mitochondrial transport (GO:0006839) | 3.17596450 |
| 105 | RNA capping (GO:0036260) | 3.16708504 |
| 106 | 7-methylguanosine RNA capping (GO:0009452) | 3.16708504 |
| 107 | protein-cofactor linkage (GO:0018065) | 3.16495016 |
| 108 | regulation of cellular amine metabolic process (GO:0033238) | 3.14055166 |
| 109 | peptidyl-histidine modification (GO:0018202) | 3.13061318 |
| 110 | establishment of integrated proviral latency (GO:0075713) | 3.12715277 |
| 111 | telomere maintenance via telomere lengthening (GO:0010833) | 3.11848441 |
| 112 | L-methionine salvage (GO:0071267) | 3.10614369 |
| 113 | L-methionine biosynthetic process (GO:0071265) | 3.10614369 |
| 114 | amino acid salvage (GO:0043102) | 3.10614369 |
| 115 | protein complex disassembly (GO:0043241) | 3.09563081 |
| 116 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.09290666 |
| 117 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.07492079 |
| 118 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.06279720 |
| 119 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.05805395 |
| 120 | ubiquinone metabolic process (GO:0006743) | 3.04950504 |
| 121 | sequestering of actin monomers (GO:0042989) | 3.04196097 |
| 122 | protein K6-linked ubiquitination (GO:0085020) | 3.03773533 |
| 123 | iron-sulfur cluster assembly (GO:0016226) | 3.02735652 |
| 124 | metallo-sulfur cluster assembly (GO:0031163) | 3.02735652 |
| 125 | kinetochore assembly (GO:0051382) | 3.01955304 |
| 126 | ATP biosynthetic process (GO:0006754) | 3.01778031 |
| 127 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.01339444 |
| 128 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.01094717 |
| 129 | DNA replication-independent nucleosome organization (GO:0034724) | 3.00668009 |
| 130 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.00668009 |
| 131 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.99033268 |
| 132 | macromolecular complex disassembly (GO:0032984) | 2.98369733 |
| 133 | IMP metabolic process (GO:0046040) | 2.97648508 |
| 134 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 2.97356218 |
| 135 | negative regulation of protein ubiquitination (GO:0031397) | 2.97126488 |
| 136 | transcription from RNA polymerase I promoter (GO:0006360) | 2.96022201 |
| 137 | positive regulation of cell cycle arrest (GO:0071158) | 2.95354531 |
| 138 | mitotic nuclear envelope disassembly (GO:0007077) | 2.94668071 |
| 139 | hydrogen ion transmembrane transport (GO:1902600) | 2.94342621 |
| 140 | mannosylation (GO:0097502) | 2.93959892 |
| 141 | protein localization to kinetochore (GO:0034501) | 2.93526714 |
| 142 | nuclear-transcribed mRNA catabolic process (GO:0000956) | 2.92489595 |
| 143 | establishment of viral latency (GO:0019043) | 2.88242007 |
| 144 | intracellular protein transmembrane import (GO:0044743) | 2.85549273 |
| 145 | GTP biosynthetic process (GO:0006183) | 2.83353809 |
| 146 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.83094772 |
| 147 | pyrimidine nucleotide catabolic process (GO:0006244) | 2.81005694 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 5.81982900 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.50640596 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 4.02507231 |
| 4 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 3.73129677 |
| 5 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.51773773 |
| 6 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.47939997 |
| 7 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.46506836 |
| 8 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.23503298 |
| 9 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.14892444 |
| 10 | * MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.01628092 |
| 11 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.97784214 |
| 12 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.91687191 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.75955644 |
| 14 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.72388963 |
| 15 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.60983769 |
| 16 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.48270133 |
| 17 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.47522468 |
| 18 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.47047583 |
| 19 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.43793699 |
| 20 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.42069032 |
| 21 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.38705809 |
| 22 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.35094791 |
| 23 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.34571413 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.20703118 |
| 25 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.19324857 |
| 26 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.18016654 |
| 27 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.09694543 |
| 28 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.04141650 |
| 29 | * SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.03094302 |
| 30 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.99498632 |
| 31 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.96761705 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.95265142 |
| 33 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.86633102 |
| 34 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.85982826 |
| 35 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.84305528 |
| 36 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.83516786 |
| 37 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.82934739 |
| 38 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.73526853 |
| 39 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.73180848 |
| 40 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.71050946 |
| 41 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.70972626 |
| 42 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.68576772 |
| 43 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.67995953 |
| 44 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.67111741 |
| 45 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.65160885 |
| 46 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.63305737 |
| 47 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.59574385 |
| 48 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.58875846 |
| 49 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.57385875 |
| 50 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.56650630 |
| 51 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.52234707 |
| 52 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.50215625 |
| 53 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.47307585 |
| 54 | * YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.47212222 |
| 55 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.45199477 |
| 56 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.44212572 |
| 57 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.43122288 |
| 58 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.40192905 |
| 59 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.39351864 |
| 60 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.31501080 |
| 61 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.31053633 |
| 62 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.30012762 |
| 63 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.29070889 |
| 64 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.28091877 |
| 65 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.20087838 |
| 66 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.20008855 |
| 67 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.17770369 |
| 68 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.15843638 |
| 69 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.11729450 |
| 70 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.11311885 |
| 71 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.08799856 |
| 72 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.07097645 |
| 73 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.06777912 |
| 74 | * ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.02636483 |
| 75 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.02121213 |
| 76 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.00266059 |
| 77 | MYC_22102868_ChIP-Seq_BL_Human | 0.99733535 |
| 78 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.97957750 |
| 79 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.97751299 |
| 80 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 0.97458114 |
| 81 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.97416134 |
| 82 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.97140020 |
| 83 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.96869904 |
| 84 | * CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.96633652 |
| 85 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.96316244 |
| 86 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.96287120 |
| 87 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.95992305 |
| 88 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.95538607 |
| 89 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.94758009 |
| 90 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.94397269 |
| 91 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.94141893 |
| 92 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.92331241 |
| 93 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.91790480 |
| 94 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 0.91347802 |
| 95 | * FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.89878471 |
| 96 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.89350126 |
| 97 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.88254193 |
| 98 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.87060043 |
| 99 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.86829976 |
| 100 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 0.84693876 |
| 101 | SPI1_23547873_ChIP-Seq_NB4_Human | 0.83563511 |
| 102 | * NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.83101272 |
| 103 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.81797151 |
| 104 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.80911801 |
| 105 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.80847896 |
| 106 | * CTCF_18555785_ChIP-Seq_MESCs_Mouse | 0.80415907 |
| 107 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 0.79797257 |
| 108 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.78482821 |
| 109 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75094554 |
| 110 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 0.73444351 |
| 111 | * SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73409889 |
| 112 | TP53_22573176_ChIP-Seq_HFKS_Human | 0.72943692 |
| 113 | CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse | 0.72820345 |
| 114 | SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 0.72566082 |
| 115 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.70865717 |
| 116 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.66692468 |
| 117 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.66357195 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.37557064 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.14243957 |
| 3 | MP0010094_abnormal_chromosome_stability | 3.59346903 |
| 4 | MP0003111_abnormal_nucleus_morphology | 3.59291728 |
| 5 | MP0003077_abnormal_cell_cycle | 3.46850489 |
| 6 | MP0003806_abnormal_nucleotide_metabolis | 3.29387300 |
| 7 | MP0008058_abnormal_DNA_repair | 3.07265731 |
| 8 | MP0008007_abnormal_cellular_replicative | 3.03477292 |
| 9 | MP0006292_abnormal_olfactory_placode | 2.75767832 |
| 10 | MP0002102_abnormal_ear_morphology | 2.71505135 |
| 11 | MP0003123_paternal_imprinting | 2.58112068 |
| 12 | MP0008057_abnormal_DNA_replication | 2.56066877 |
| 13 | MP0008932_abnormal_embryonic_tissue | 2.53681905 |
| 14 | MP0001529_abnormal_vocalization | 2.48974073 |
| 15 | MP0008789_abnormal_olfactory_epithelium | 2.48617521 |
| 16 | MP0003186_abnormal_redox_activity | 2.21362542 |
| 17 | MP0002938_white_spotting | 2.17720055 |
| 18 | MP0004145_abnormal_muscle_electrophysio | 2.14696174 |
| 19 | MP0002396_abnormal_hematopoietic_system | 2.10940425 |
| 20 | MP0003786_premature_aging | 2.06500371 |
| 21 | MP0003136_yellow_coat_color | 2.02302423 |
| 22 | MP0003718_maternal_effect | 2.01135997 |
| 23 | MP0001730_embryonic_growth_arrest | 1.98641320 |
| 24 | MP0006036_abnormal_mitochondrial_physio | 1.92722847 |
| 25 | MP0003646_muscle_fatigue | 1.85727354 |
| 26 | MP0000350_abnormal_cell_proliferation | 1.77756489 |
| 27 | MP0008877_abnormal_DNA_methylation | 1.76343785 |
| 28 | MP0003315_abnormal_perineum_morphology | 1.72566280 |
| 29 | MP0005084_abnormal_gallbladder_morpholo | 1.66739025 |
| 30 | MP0000490_abnormal_crypts_of | 1.65137380 |
| 31 | MP0005499_abnormal_olfactory_system | 1.61683891 |
| 32 | MP0005394_taste/olfaction_phenotype | 1.61683891 |
| 33 | MP0003567_abnormal_fetal_cardiomyocyte | 1.59816720 |
| 34 | MP0002277_abnormal_respiratory_mucosa | 1.49808446 |
| 35 | MP0001697_abnormal_embryo_size | 1.48903487 |
| 36 | MP0003941_abnormal_skin_development | 1.48537491 |
| 37 | MP0009333_abnormal_splenocyte_physiolog | 1.48495881 |
| 38 | MP0002132_abnormal_respiratory_system | 1.46663440 |
| 39 | MP0006035_abnormal_mitochondrial_morpho | 1.46454483 |
| 40 | MP0010352_gastrointestinal_tract_polyps | 1.44239188 |
| 41 | MP0005408_hypopigmentation | 1.42275924 |
| 42 | MP0004147_increased_porphyrin_level | 1.41883750 |
| 43 | MP0000313_abnormal_cell_death | 1.41715794 |
| 44 | MP0005397_hematopoietic_system_phenotyp | 1.37605188 |
| 45 | MP0001545_abnormal_hematopoietic_system | 1.37605188 |
| 46 | MP0002638_abnormal_pupillary_reflex | 1.36616797 |
| 47 | MP0004808_abnormal_hematopoietic_stem | 1.35057729 |
| 48 | MP0002080_prenatal_lethality | 1.34948438 |
| 49 | MP0002837_dystrophic_cardiac_calcinosis | 1.34786540 |
| 50 | MP0001672_abnormal_embryogenesis/_devel | 1.33807650 |
| 51 | MP0005380_embryogenesis_phenotype | 1.33807650 |
| 52 | MP0003011_delayed_dark_adaptation | 1.33518464 |
| 53 | MP0004084_abnormal_cardiac_muscle | 1.32444652 |
| 54 | MP0001905_abnormal_dopamine_level | 1.31613147 |
| 55 | MP0003984_embryonic_growth_retardation | 1.29944934 |
| 56 | MP0002019_abnormal_tumor_incidence | 1.28374693 |
| 57 | MP0008995_early_reproductive_senescence | 1.27131163 |
| 58 | MP0002088_abnormal_embryonic_growth/wei | 1.26935619 |
| 59 | MP0002095_abnormal_skin_pigmentation | 1.26528295 |
| 60 | MP0002736_abnormal_nociception_after | 1.25466769 |
| 61 | MP0002234_abnormal_pharynx_morphology | 1.23624377 |
| 62 | MP0005171_absent_coat_pigmentation | 1.23137827 |
| 63 | MP0001984_abnormal_olfaction | 1.20463127 |
| 64 | MP0000049_abnormal_middle_ear | 1.20314107 |
| 65 | MP0000358_abnormal_cell_content/ | 1.13825430 |
| 66 | MP0004142_abnormal_muscle_tone | 1.12790141 |
| 67 | MP0001293_anophthalmia | 1.12703226 |
| 68 | MP0005266_abnormal_metabolism | 1.12453921 |
| 69 | MP0010030_abnormal_orbit_morphology | 1.12410222 |
| 70 | MP0005075_abnormal_melanosome_morpholog | 1.08763511 |
| 71 | MP0000750_abnormal_muscle_regeneration | 1.08103313 |
| 72 | MP0002086_abnormal_extraembryonic_tissu | 1.08072552 |
| 73 | MP0009379_abnormal_foot_pigmentation | 1.06603361 |
| 74 | MP0005253_abnormal_eye_physiology | 1.06449913 |
| 75 | MP0002085_abnormal_embryonic_tissue | 1.05907039 |
| 76 | MP0006276_abnormal_autonomic_nervous | 1.04084799 |
| 77 | MP0003763_abnormal_thymus_physiology | 1.02922652 |
| 78 | MP0006072_abnormal_retinal_apoptosis | 1.02277512 |
| 79 | MP0001764_abnormal_homeostasis | 1.01143610 |
| 80 | MP0001853_heart_inflammation | 0.98989878 |
| 81 | MP0009697_abnormal_copulation | 0.98725887 |
| 82 | MP0005083_abnormal_biliary_tract | 0.98719220 |
| 83 | MP0003221_abnormal_cardiomyocyte_apopto | 0.98183208 |
| 84 | MP0009053_abnormal_anal_canal | 0.97600713 |
| 85 | MP0003283_abnormal_digestive_organ | 0.97579904 |
| 86 | MP0003878_abnormal_ear_physiology | 0.97106804 |
| 87 | MP0005377_hearing/vestibular/ear_phenot | 0.97106804 |
| 88 | MP0004197_abnormal_fetal_growth/weight/ | 0.93648491 |
| 89 | MP0002160_abnormal_reproductive_system | 0.93465969 |
| 90 | MP0003137_abnormal_impulse_conducting | 0.93307894 |
| 91 | MP0002090_abnormal_vision | 0.91965328 |
| 92 | MP0002210_abnormal_sex_determination | 0.90755961 |
| 93 | MP0000749_muscle_degeneration | 0.87488650 |
| 94 | MP0000689_abnormal_spleen_morphology | 0.86658174 |
| 95 | MP0005330_cardiomyopathy | 0.86493995 |
| 96 | MP0001929_abnormal_gametogenesis | 0.86335711 |
| 97 | MP0001145_abnormal_male_reproductive | 0.86163090 |
| 98 | MP0003195_calcinosis | 0.86108295 |
| 99 | MP0003566_abnormal_cell_adhesion | 0.84674921 |
| 100 | MP0002722_abnormal_immune_system | 0.84466171 |
| 101 | MP0002084_abnormal_developmental_patter | 0.82765009 |
| 102 | MP0006138_congestive_heart_failure | 0.82466644 |
| 103 | MP0003119_abnormal_digestive_system | 0.82066477 |
| 104 | MP0000858_altered_metastatic_potential | 0.81684004 |
| 105 | MP0004133_heterotaxia | 0.81443484 |
| 106 | MP0001324_abnormal_eye_pigmentation | 0.80931289 |
| 107 | MP0002163_abnormal_gland_morphology | 0.80525849 |
| 108 | MP0000751_myopathy | 0.80183790 |
| 109 | MP0002233_abnormal_nose_morphology | 0.79805210 |
| 110 | MP0001119_abnormal_female_reproductive | 0.78455583 |
| 111 | MP0001188_hyperpigmentation | 0.78270330 |
| 112 | MP0002398_abnormal_bone_marrow | 0.77789145 |
| 113 | MP0001542_abnormal_bone_strength | 0.77672448 |
| 114 | MP0001986_abnormal_taste_sensitivity | 0.74569997 |
| 115 | MP0002106_abnormal_muscle_physiology | 0.73980721 |
| 116 | MP0009046_muscle_twitch | 0.73625686 |
| 117 | MP0000372_irregular_coat_pigmentation | 0.72965817 |
| 118 | MP0002429_abnormal_blood_cell | 0.72581729 |
| 119 | MP0002751_abnormal_autonomic_nervous | 0.72382756 |
| 120 | MP0004215_abnormal_myocardial_fiber | 0.72377402 |
| 121 | MP0000703_abnormal_thymus_morphology | 0.71992081 |
| 122 | MP0005384_cellular_phenotype | 0.71346888 |
| 123 | MP0000653_abnormal_sex_gland | 0.71326401 |
| 124 | MP0006054_spinal_hemorrhage | 0.70360063 |
| 125 | MP0001727_abnormal_embryo_implantation | 0.70347644 |
| 126 | MP0000477_abnormal_intestine_morphology | 0.69601268 |
| 127 | MP0002111_abnormal_tail_morphology | 0.67895379 |
| 128 | MP0002269_muscular_atrophy | 0.67614275 |
| 129 | MP0000631_abnormal_neuroendocrine_gland | 0.67611229 |
| 130 | MP0005389_reproductive_system_phenotype | 0.67427384 |
| 131 | MP0008872_abnormal_physiological_respon | 0.67176910 |
| 132 | MP0002177_abnormal_outer_ear | 0.66425323 |
| 133 | MP0001968_abnormal_touch/_nociception | 0.66395107 |
| 134 | MP0000015_abnormal_ear_pigmentation | 0.65461981 |
| 135 | MP0005332_abnormal_amino_acid | 0.65288379 |
| 136 | MP0001835_abnormal_antigen_presentation | 0.64625203 |
| 137 | MP0003828_pulmonary_edema | 0.63398620 |
| 138 | MP0000343_altered_response_to | 0.60922206 |
| 139 | MP0003122_maternal_imprinting | 0.60647144 |
| 140 | MP0005376_homeostasis/metabolism_phenot | 0.60178246 |
| 141 | MP0005369_muscle_phenotype | 0.60129310 |
| 142 | MP0003943_abnormal_hepatobiliary_system | 0.59572641 |
| 143 | MP0005621_abnormal_cell_physiology | 0.59548822 |
| 144 | MP0005451_abnormal_body_composition | 0.58833141 |
| 145 | MP0001544_abnormal_cardiovascular_syste | 0.58145708 |
| 146 | MP0005385_cardiovascular_system_phenoty | 0.58145708 |
| 147 | MP0010307_abnormal_tumor_latency | 0.56642220 |
| 148 | MP0002127_abnormal_cardiovascular_syste | 0.56453570 |
| 149 | MP0004233_abnormal_muscle_weight | 0.55962161 |
| 150 | MP0000678_abnormal_parathyroid_gland | 0.55851744 |
| 151 | MP0003121_genomic_imprinting | 0.54998971 |
| 152 | MP0004782_abnormal_surfactant_physiolog | 0.54927238 |
| 153 | MP0009672_abnormal_birth_weight | 0.54880880 |
| 154 | MP0002653_abnormal_ependyma_morphology | 0.54810419 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.91369797 |
| 2 | Breast hypoplasia (HP:0003187) | 4.30528758 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 4.28786373 |
| 4 | Reticulocytopenia (HP:0001896) | 4.11709979 |
| 5 | Abnormal number of erythroid precursors (HP:0012131) | 4.06997587 |
| 6 | Aplastic anemia (HP:0001915) | 3.88576911 |
| 7 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.69616519 |
| 8 | Microretrognathia (HP:0000308) | 3.64603963 |
| 9 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.53064372 |
| 10 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.53064372 |
| 11 | Mitochondrial inheritance (HP:0001427) | 3.48323460 |
| 12 | Acute necrotizing encephalopathy (HP:0006965) | 3.47347882 |
| 13 | Carpal bone hypoplasia (HP:0001498) | 3.41605241 |
| 14 | Oral leukoplakia (HP:0002745) | 3.38639669 |
| 15 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.36461679 |
| 16 | Increased CSF lactate (HP:0002490) | 3.32803085 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.26810827 |
| 18 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.25796000 |
| 19 | Hepatic necrosis (HP:0002605) | 3.24117080 |
| 20 | Increased hepatocellular lipid droplets (HP:0006565) | 3.18216358 |
| 21 | Increased serum lactate (HP:0002151) | 3.15321681 |
| 22 | Rough bone trabeculation (HP:0100670) | 3.14378273 |
| 23 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03917516 |
| 24 | Lipid accumulation in hepatocytes (HP:0006561) | 3.02136450 |
| 25 | Macrocytic anemia (HP:0001972) | 3.00878757 |
| 26 | Abnormality of the anterior horn cell (HP:0006802) | 2.97443199 |
| 27 | Degeneration of anterior horn cells (HP:0002398) | 2.97443199 |
| 28 | Acute encephalopathy (HP:0006846) | 2.94989362 |
| 29 | Increased intramyocellular lipid droplets (HP:0012240) | 2.86988576 |
| 30 | Abnormal protein glycosylation (HP:0012346) | 2.86773452 |
| 31 | Abnormal glycosylation (HP:0012345) | 2.86773452 |
| 32 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.86773452 |
| 33 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.86773452 |
| 34 | Patellar aplasia (HP:0006443) | 2.80371379 |
| 35 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.79097356 |
| 36 | Abnormality of alanine metabolism (HP:0010916) | 2.79097356 |
| 37 | Hyperalaninemia (HP:0003348) | 2.79097356 |
| 38 | Multiple enchondromatosis (HP:0005701) | 2.77147301 |
| 39 | Cerebral hypomyelination (HP:0006808) | 2.76178335 |
| 40 | Abnormality of glycolysis (HP:0004366) | 2.72746583 |
| 41 | Increased serum pyruvate (HP:0003542) | 2.72746583 |
| 42 | Exercise intolerance (HP:0003546) | 2.71724927 |
| 43 | Respiratory difficulties (HP:0002880) | 2.69497793 |
| 44 | Exertional dyspnea (HP:0002875) | 2.68957070 |
| 45 | Lactic acidosis (HP:0003128) | 2.68759974 |
| 46 | Pallor (HP:0000980) | 2.66302913 |
| 47 | Irregular epiphyses (HP:0010582) | 2.65487109 |
| 48 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.65310472 |
| 49 | Progressive muscle weakness (HP:0003323) | 2.63744199 |
| 50 | Selective tooth agenesis (HP:0001592) | 2.63330370 |
| 51 | Generalized aminoaciduria (HP:0002909) | 2.59856798 |
| 52 | Increased muscle lipid content (HP:0009058) | 2.59316962 |
| 53 | Optic disc pallor (HP:0000543) | 2.56814133 |
| 54 | Trismus (HP:0000211) | 2.56521985 |
| 55 | Type I transferrin isoform profile (HP:0003642) | 2.53324774 |
| 56 | Nemaline bodies (HP:0003798) | 2.51484308 |
| 57 | Hypoplastic pelvis (HP:0008839) | 2.47947061 |
| 58 | Progressive macrocephaly (HP:0004481) | 2.44082675 |
| 59 | Amniotic constriction ring (HP:0009775) | 2.41429941 |
| 60 | Abnormality of placental membranes (HP:0011409) | 2.41429941 |
| 61 | Lethargy (HP:0001254) | 2.37500538 |
| 62 | Renal Fanconi syndrome (HP:0001994) | 2.37137107 |
| 63 | Reduced antithrombin III activity (HP:0001976) | 2.36796985 |
| 64 | Abnormality of renal resorption (HP:0011038) | 2.36365585 |
| 65 | Muscle fiber inclusion bodies (HP:0100299) | 2.34982855 |
| 66 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.32514391 |
| 67 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.28542873 |
| 68 | Premature ovarian failure (HP:0008209) | 2.27984173 |
| 69 | Respiratory failure (HP:0002878) | 2.27165226 |
| 70 | Colon cancer (HP:0003003) | 2.24508952 |
| 71 | Methylmalonic aciduria (HP:0012120) | 2.23112581 |
| 72 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.22381519 |
| 73 | Pancytopenia (HP:0001876) | 2.20927377 |
| 74 | Sparse eyelashes (HP:0000653) | 2.18861063 |
| 75 | Leukodystrophy (HP:0002415) | 2.18100196 |
| 76 | Secondary amenorrhea (HP:0000869) | 2.16860900 |
| 77 | Absent thumb (HP:0009777) | 2.16628665 |
| 78 | Nausea (HP:0002018) | 2.16337653 |
| 79 | Abnormal trabecular bone morphology (HP:0100671) | 2.15978317 |
| 80 | Premature graying of hair (HP:0002216) | 2.15822307 |
| 81 | Methylmalonic acidemia (HP:0002912) | 2.14686975 |
| 82 | 11 pairs of ribs (HP:0000878) | 2.12023848 |
| 83 | Cerebral edema (HP:0002181) | 2.11951249 |
| 84 | Breech presentation (HP:0001623) | 2.09394700 |
| 85 | Chromsome breakage (HP:0040012) | 2.07416684 |
| 86 | Petechiae (HP:0000967) | 2.07042844 |
| 87 | Thrombocytosis (HP:0001894) | 2.05744196 |
| 88 | Exercise-induced muscle cramps (HP:0003710) | 2.04044451 |
| 89 | Pancreatic cysts (HP:0001737) | 2.03654879 |
| 90 | Cellular immunodeficiency (HP:0005374) | 2.01871205 |
| 91 | Microvesicular hepatic steatosis (HP:0001414) | 2.00580817 |
| 92 | X-linked dominant inheritance (HP:0001423) | 1.99837642 |
| 93 | Rhabdomyolysis (HP:0003201) | 1.98875499 |
| 94 | Glycosuria (HP:0003076) | 1.98111561 |
| 95 | Abnormality of urine glucose concentration (HP:0011016) | 1.98111561 |
| 96 | Flat capital femoral epiphysis (HP:0003370) | 1.97754389 |
| 97 | Neoplasm of the pancreas (HP:0002894) | 1.97666624 |
| 98 | Hypoplasia of the radius (HP:0002984) | 1.96905590 |
| 99 | CNS demyelination (HP:0007305) | 1.96694373 |
| 100 | Abnormality of the labia minora (HP:0012880) | 1.95494064 |
| 101 | Hyperglycinemia (HP:0002154) | 1.95265947 |
| 102 | Posterior subcapsular cataract (HP:0007787) | 1.95010759 |
| 103 | Abnormality of the preputium (HP:0100587) | 1.94966652 |
| 104 | Abnormal lung lobation (HP:0002101) | 1.93762616 |
| 105 | Abnormality of methionine metabolism (HP:0010901) | 1.89427067 |
| 106 | Abnormal cartilage morphology (HP:0002763) | 1.88395096 |
| 107 | Ragged-red muscle fibers (HP:0003200) | 1.87942366 |
| 108 | Meckel diverticulum (HP:0002245) | 1.86987953 |
| 109 | Slender long bone (HP:0003100) | 1.86214654 |
| 110 | Horseshoe kidney (HP:0000085) | 1.85984559 |
| 111 | Unsteady gait (HP:0002317) | 1.84208695 |
| 112 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.83240048 |
| 113 | Poor suck (HP:0002033) | 1.83130491 |
| 114 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.80479500 |
| 115 | Dicarboxylic aciduria (HP:0003215) | 1.80479500 |
| 116 | Cleft eyelid (HP:0000625) | 1.80365644 |
| 117 | Abnormality of the ileum (HP:0001549) | 1.80080023 |
| 118 | Emotional lability (HP:0000712) | 1.77636033 |
| 119 | Absent radius (HP:0003974) | 1.77299003 |
| 120 | Abnormality of midbrain morphology (HP:0002418) | 1.76919462 |
| 121 | Molar tooth sign on MRI (HP:0002419) | 1.76919462 |
| 122 | Muscle fiber atrophy (HP:0100295) | 1.76699003 |
| 123 | Abnormal number of incisors (HP:0011064) | 1.76568063 |
| 124 | Areflexia of lower limbs (HP:0002522) | 1.75723381 |
| 125 | Abnormality of chromosome stability (HP:0003220) | 1.73979784 |
| 126 | Type 2 muscle fiber atrophy (HP:0003554) | 1.72861055 |
| 127 | Tongue fasciculations (HP:0001308) | 1.72176512 |
| 128 | Abnormality of the umbilical cord (HP:0010881) | 1.71896221 |
| 129 | Bone marrow hypocellularity (HP:0005528) | 1.71513316 |
| 130 | IgM deficiency (HP:0002850) | 1.71419254 |
| 131 | Renal cortical cysts (HP:0000803) | 1.71336413 |
| 132 | Megaloblastic anemia (HP:0001889) | 1.70831951 |
| 133 | Opisthotonus (HP:0002179) | 1.70172552 |
| 134 | Pancreatic fibrosis (HP:0100732) | 1.70093859 |
| 135 | Medial flaring of the eyebrow (HP:0010747) | 1.67846537 |
| 136 | True hermaphroditism (HP:0010459) | 1.67344643 |
| 137 | Abnormality of the fovea (HP:0000493) | 1.66742978 |
| 138 | Progressive microcephaly (HP:0000253) | 1.65849547 |
| 139 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.63850227 |
| 140 | Abnormality of serum amino acid levels (HP:0003112) | 1.62342709 |
| 141 | Sclerocornea (HP:0000647) | 1.62310301 |
| 142 | Adrenal hypoplasia (HP:0000835) | 1.61876881 |
| 143 | Median cleft lip (HP:0000161) | 1.61415859 |
| 144 | Hypoplasia of the fovea (HP:0007750) | 1.59079561 |
| 145 | Aplasia/Hypoplasia of the fovea (HP:0008060) | 1.59079561 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 4.34236542 |
| 2 | TIE1 | 4.28658505 |
| 3 | VRK2 | 4.14720094 |
| 4 | WEE1 | 3.99477501 |
| 5 | EIF2AK1 | 3.56084769 |
| 6 | NME2 | 3.48475007 |
| 7 | TSSK6 | 2.50142522 |
| 8 | EIF2AK3 | 2.33208857 |
| 9 | BCKDK | 2.30763324 |
| 10 | CDC7 | 2.20747111 |
| 11 | TAOK3 | 2.15397617 |
| 12 | PIM2 | 2.15199777 |
| 13 | PLK4 | 2.14444661 |
| 14 | STK16 | 2.08452666 |
| 15 | TRIM28 | 2.03052002 |
| 16 | NEK1 | 2.02605617 |
| 17 | BRSK2 | 1.90012089 |
| 18 | SRPK1 | 1.86624227 |
| 19 | ACVR1B | 1.85752984 |
| 20 | CSNK1G3 | 1.85534029 |
| 21 | VRK1 | 1.71832238 |
| 22 | TTK | 1.65809625 |
| 23 | KDR | 1.61721447 |
| 24 | NUAK1 | 1.61672321 |
| 25 | PLK1 | 1.61260729 |
| 26 | DYRK3 | 1.58059283 |
| 27 | ZAK | 1.55440401 |
| 28 | TESK2 | 1.52668427 |
| 29 | TGFBR1 | 1.51636583 |
| 30 | CSNK1G1 | 1.49253650 |
| 31 | CSNK1A1L | 1.42947776 |
| 32 | EPHA2 | 1.41252837 |
| 33 | CSNK1G2 | 1.40154983 |
| 34 | PASK | 1.38563556 |
| 35 | NEK2 | 1.37955679 |
| 36 | TEC | 1.36664194 |
| 37 | AURKB | 1.32012146 |
| 38 | BMPR1B | 1.29359714 |
| 39 | MAP4K2 | 1.26464552 |
| 40 | RPS6KA4 | 1.26373275 |
| 41 | IRAK3 | 1.24993174 |
| 42 | CDK7 | 1.24200757 |
| 43 | MAP2K7 | 1.23565815 |
| 44 | WNK3 | 1.23338116 |
| 45 | NME1 | 1.22060751 |
| 46 | CDK8 | 1.20008282 |
| 47 | PHKG2 | 1.17959187 |
| 48 | PHKG1 | 1.17959187 |
| 49 | RPS6KB2 | 1.15922987 |
| 50 | MAP3K11 | 1.14238959 |
| 51 | BRSK1 | 1.13856118 |
| 52 | ATR | 1.08774623 |
| 53 | MAPKAPK3 | 1.07705583 |
| 54 | CCNB1 | 1.06627249 |
| 55 | PLK3 | 1.05272399 |
| 56 | BRAF | 1.01724681 |
| 57 | MKNK1 | 0.97666133 |
| 58 | ARAF | 0.97388570 |
| 59 | AURKA | 0.96029297 |
| 60 | ILK | 0.93844980 |
| 61 | STK38L | 0.93451512 |
| 62 | FLT3 | 0.92661901 |
| 63 | ADRBK2 | 0.91848427 |
| 64 | PINK1 | 0.91525940 |
| 65 | MYLK | 0.90870322 |
| 66 | PAK4 | 0.89711712 |
| 67 | BCR | 0.85151890 |
| 68 | MAP2K3 | 0.82657468 |
| 69 | PDK4 | 0.81981551 |
| 70 | PDK3 | 0.81981551 |
| 71 | PBK | 0.79106783 |
| 72 | EIF2AK2 | 0.77724985 |
| 73 | MAP3K8 | 0.76104825 |
| 74 | TLK1 | 0.76101808 |
| 75 | CHEK2 | 0.75374954 |
| 76 | TESK1 | 0.73749424 |
| 77 | PLK2 | 0.72219991 |
| 78 | MAP3K12 | 0.70510762 |
| 79 | CDK4 | 0.68316950 |
| 80 | MUSK | 0.68028119 |
| 81 | DYRK2 | 0.67825636 |
| 82 | CSNK2A1 | 0.67588347 |
| 83 | PRKCI | 0.65758067 |
| 84 | OBSCN | 0.64500418 |
| 85 | PIK3CG | 0.64296997 |
| 86 | ERBB3 | 0.62119407 |
| 87 | MAP3K3 | 0.62112905 |
| 88 | GRK7 | 0.60122115 |
| 89 | SIK3 | 0.59847955 |
| 90 | EPHB2 | 0.59770202 |
| 91 | PIM1 | 0.58820717 |
| 92 | CSNK2A2 | 0.58647834 |
| 93 | AKT3 | 0.58643830 |
| 94 | MKNK2 | 0.56685733 |
| 95 | CHEK1 | 0.55943341 |
| 96 | STK24 | 0.55719798 |
| 97 | GRK1 | 0.54491679 |
| 98 | PAK1 | 0.54323100 |
| 99 | LMTK2 | 0.50532828 |
| 100 | DAPK3 | 0.50396947 |
| 101 | ABL2 | 0.49820893 |
| 102 | PDK2 | 0.48670736 |
| 103 | LRRK2 | 0.47534584 |
| 104 | LATS2 | 0.44539891 |
| 105 | INSRR | 0.44464080 |
| 106 | DAPK1 | 0.43771659 |
| 107 | ATM | 0.41864941 |
| 108 | CSNK1A1 | 0.41565859 |
| 109 | STK4 | 0.41141111 |
| 110 | LIMK1 | 0.40958906 |
| 111 | MINK1 | 0.39908144 |
| 112 | ERN1 | 0.39629563 |
| 113 | GRK5 | 0.39394009 |
| 114 | AKT2 | 0.38350602 |
| 115 | MAP4K1 | 0.37718515 |
| 116 | CDK2 | 0.35006603 |
| 117 | MAP3K5 | 0.34669718 |
| 118 | MAPK13 | 0.34171469 |
| 119 | PRKCG | 0.33250095 |
| 120 | MAP2K2 | 0.32915128 |
| 121 | SCYL2 | 0.32060598 |
| 122 | CDK19 | 0.31995472 |
| 123 | TAOK2 | 0.31980635 |
| 124 | TAF1 | 0.30976268 |
| 125 | RAF1 | 0.30957828 |
| 126 | PKN1 | 0.30312745 |
| 127 | WNK4 | 0.30198067 |
| 128 | RPS6KA5 | 0.29556530 |
| 129 | STK10 | 0.28039795 |
| 130 | MST4 | 0.27850611 |
| 131 | ADRBK1 | 0.27343599 |
| 132 | ZAP70 | 0.27296066 |
| 133 | CAMK2G | 0.26467490 |
| 134 | CSNK1E | 0.26357576 |
| 135 | CDK14 | 0.24058627 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Ribosome_Homo sapiens_hsa03010 | 4.42459335 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.22454289 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.01984333 |
| 4 | RNA polymerase_Homo sapiens_hsa03020 | 3.81289457 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.40813604 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.38917809 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 2.77441774 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.73583951 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.59004711 |
| 10 | Base excision repair_Homo sapiens_hsa03410 | 2.55492462 |
| 11 | Homologous recombination_Homo sapiens_hsa03440 | 2.52759842 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.26558642 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.17803787 |
| 14 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.16643709 |
| 15 | Parkinsons disease_Homo sapiens_hsa05012 | 2.10409215 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.06155039 |
| 17 | Cell cycle_Homo sapiens_hsa04110 | 1.96299803 |
| 18 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.87521556 |
| 19 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.83586703 |
| 20 | Sulfur relay system_Homo sapiens_hsa04122 | 1.69424915 |
| 21 | Basal transcription factors_Homo sapiens_hsa03022 | 1.68468233 |
| 22 | Huntingtons disease_Homo sapiens_hsa05016 | 1.67188847 |
| 23 | RNA degradation_Homo sapiens_hsa03018 | 1.62871856 |
| 24 | Protein export_Homo sapiens_hsa03060 | 1.52929667 |
| 25 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.49031067 |
| 26 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.48070508 |
| 27 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.46929910 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.44427051 |
| 29 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.41401359 |
| 30 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.36168078 |
| 31 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.31582553 |
| 32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.28821342 |
| 33 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.26861894 |
| 34 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 1.26231999 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.25926317 |
| 36 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.20043669 |
| 37 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.17304148 |
| 38 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 1.16343394 |
| 39 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.13897532 |
| 40 | Alzheimers disease_Homo sapiens_hsa05010 | 1.11945771 |
| 41 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.07619518 |
| 42 | Carbon metabolism_Homo sapiens_hsa01200 | 1.07618517 |
| 43 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 1.06238902 |
| 44 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.01655938 |
| 45 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.94705864 |
| 46 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.94389204 |
| 47 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.87269812 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.84608072 |
| 49 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.82674710 |
| 50 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.81603965 |
| 51 | Galactose metabolism_Homo sapiens_hsa00052 | 0.79739346 |
| 52 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.75140347 |
| 53 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.72526607 |
| 54 | Legionellosis_Homo sapiens_hsa05134 | 0.71172444 |
| 55 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.71122834 |
| 56 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.68450662 |
| 57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.66223825 |
| 58 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.65598460 |
| 59 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.64392264 |
| 60 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.59266872 |
| 61 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.58617724 |
| 62 | Metabolic pathways_Homo sapiens_hsa01100 | 0.57811701 |
| 63 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.56618351 |
| 64 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.52966031 |
| 65 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.50032490 |
| 66 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.48629421 |
| 67 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.48591335 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47778972 |
| 69 | Thyroid cancer_Homo sapiens_hsa05216 | 0.47194401 |
| 70 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.46970142 |
| 71 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.43037395 |
| 72 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.42955124 |
| 73 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.41866709 |
| 74 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.40892062 |
| 75 | Phototransduction_Homo sapiens_hsa04744 | 0.40846478 |
| 76 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.39568882 |
| 77 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.38456032 |
| 78 | HTLV-I infection_Homo sapiens_hsa05166 | 0.37705019 |
| 79 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.35689300 |
| 80 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.34583744 |
| 81 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.33847294 |
| 82 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33473497 |
| 83 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.32511898 |
| 84 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.32360798 |
| 85 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.31963267 |
| 86 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.31753967 |
| 87 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.31457929 |
| 88 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.31169411 |
| 89 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.30840470 |
| 90 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.30028125 |
| 91 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.26483512 |
| 92 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.26311575 |
| 93 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.25467768 |
| 94 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.25422488 |
| 95 | Apoptosis_Homo sapiens_hsa04210 | 0.24298860 |
| 96 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.22165582 |
| 97 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.21686027 |
| 98 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.20372349 |
| 99 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.16433500 |
| 100 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 0.14499977 |
| 101 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.13562430 |
| 102 | Measles_Homo sapiens_hsa05162 | 0.13369416 |
| 103 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.12311879 |
| 104 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.12055662 |
| 105 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.11532158 |
| 106 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.11115365 |
| 107 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.10981089 |
| 108 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.10502597 |
| 109 | Peroxisome_Homo sapiens_hsa04146 | 0.10408636 |
| 110 | Circadian rhythm_Homo sapiens_hsa04710 | 0.10332327 |
| 111 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.09965513 |
| 112 | Influenza A_Homo sapiens_hsa05164 | 0.08577430 |
| 113 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.08379193 |
| 114 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.07894337 |
| 115 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.07321776 |
| 116 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.07165422 |
| 117 | Shigellosis_Homo sapiens_hsa05131 | 0.07163634 |
| 118 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.07098198 |
| 119 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.06517515 |
| 120 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.06511702 |
| 121 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.05750216 |
| 122 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.04639223 |
| 123 | Other glycan degradation_Homo sapiens_hsa00511 | 0.04428487 |
| 124 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.04329842 |

