TMEM110

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of p38MAPK cascade (GO:1900745)5.04323467
2pyrimidine-containing compound transmembrane transport (GO:0072531)4.39236921
3fatty-acyl-CoA biosynthetic process (GO:0046949)4.34126103
4central nervous system myelination (GO:0022010)4.30993262
5axon ensheathment in central nervous system (GO:0032291)4.30993262
6negative regulation of erythrocyte differentiation (GO:0045647)4.29640210
7pentose-phosphate shunt (GO:0006098)4.27568447
8long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.27004870
9surfactant homeostasis (GO:0043129)4.17674755
10alpha-linolenic acid metabolic process (GO:0036109)4.08222095
11acyl-CoA biosynthetic process (GO:0071616)3.95639343
12thioester biosynthetic process (GO:0035384)3.95639343
13positive regulation of gamma-delta T cell activation (GO:0046645)3.91745822
14response to peptidoglycan (GO:0032494)3.82101188
15fatty acid elongation (GO:0030497)3.81278590
16NADPH regeneration (GO:0006740)3.78972949
17activation of MAPKKK activity (GO:0000185)3.75437382
18valine metabolic process (GO:0006573)3.70992655
19epithelial cell differentiation involved in prostate gland development (GO:0060742)3.60966960
20regulation of p38MAPK cascade (GO:1900744)3.60728269
21creatine metabolic process (GO:0006600)3.59930152
22positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.58878386
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.56219031
24negative regulation of cell killing (GO:0031342)3.56219031
25protein localization to endosome (GO:0036010)3.50438256
26negative regulation of interleukin-12 production (GO:0032695)3.48681759
27fatty-acyl-CoA metabolic process (GO:0035337)3.47970573
28positive regulation of cellular amide metabolic process (GO:0034250)3.44929232
29positive regulation of histone deacetylation (GO:0031065)3.43140694
30lung epithelium development (GO:0060428)3.41158729
31polarized epithelial cell differentiation (GO:0030859)3.40120626
32axon ensheathment (GO:0008366)3.38462913
33ensheathment of neurons (GO:0007272)3.38462913
34positive regulation by symbiont of host defense response (GO:0052509)3.36117597
35modulation by symbiont of host defense response (GO:0052031)3.36117597
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.36117597
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.36117597
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.36117597
39modulation by symbiont of host immune response (GO:0052553)3.36117597
40response to muramyl dipeptide (GO:0032495)3.31961197
41regulation of mitotic spindle organization (GO:0060236)3.29009614
42negative regulation of response to reactive oxygen species (GO:1901032)3.28981636
43myelination (GO:0042552)3.28318845
44long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.26641130
45low-density lipoprotein particle clearance (GO:0034383)3.23911668
46triglyceride biosynthetic process (GO:0019432)3.23789884
47collecting duct development (GO:0072044)3.23410981
48mature B cell differentiation involved in immune response (GO:0002313)3.22280646
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.21830801
50L-phenylalanine metabolic process (GO:0006558)3.21830801
51detection of other organism (GO:0098543)3.20186723
52pattern specification involved in kidney development (GO:0061004)3.18031964
53type I interferon signaling pathway (GO:0060337)3.17989933
54cellular response to type I interferon (GO:0071357)3.17989933
55acylglycerol biosynthetic process (GO:0046463)3.15202025
56neutral lipid biosynthetic process (GO:0046460)3.15202025
57cortical actin cytoskeleton organization (GO:0030866)3.14553358
58myelin maintenance (GO:0043217)3.13097140
59acetyl-CoA metabolic process (GO:0006084)3.12751985
60response to type I interferon (GO:0034340)3.11443931
61barbed-end actin filament capping (GO:0051016)3.11235497
62histone H3-K36 demethylation (GO:0070544)3.10354263
63negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.08214395
64triglyceride catabolic process (GO:0019433)3.03248171
65macrophage activation involved in immune response (GO:0002281)3.02847333
66maternal placenta development (GO:0001893)3.00481390
67regulation of NFAT protein import into nucleus (GO:0051532)2.99976751
68positive regulation of triglyceride metabolic process (GO:0090208)2.97464778
69positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97156760
70virion attachment to host cell (GO:0019062)2.96282310
71adhesion of symbiont to host cell (GO:0044650)2.96282310
72detection of bacterium (GO:0016045)2.95418619
73nucleoside transmembrane transport (GO:1901642)2.95062108
74stress fiber assembly (GO:0043149)2.94226700
75regulation of monocyte differentiation (GO:0045655)2.94089293
76lipopolysaccharide-mediated signaling pathway (GO:0031663)2.92413987
77regulation of type I interferon-mediated signaling pathway (GO:0060338)2.92156249
78biotin metabolic process (GO:0006768)2.91617054
79regulation of gamma-delta T cell activation (GO:0046643)2.91421324
80L-phenylalanine catabolic process (GO:0006559)2.90710025
81erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.90710025
82hypotonic response (GO:0006971)2.90085380
83regulation of sequestering of triglyceride (GO:0010889)2.89864885
84detection of molecule of bacterial origin (GO:0032490)2.88923077
85regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.87626630
86regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.87167916
87acylglycerol catabolic process (GO:0046464)2.87022044
88neutral lipid catabolic process (GO:0046461)2.87022044
89positive regulation of triglyceride biosynthetic process (GO:0010867)2.85347238
90JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.84725950
91negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.83710208
92cellular extravasation (GO:0045123)2.83565944
933-UTR-mediated mRNA stabilization (GO:0070935)2.79902576
94germinal center formation (GO:0002467)2.79859511
95regulation of triglyceride metabolic process (GO:0090207)2.79643368
96plasma lipoprotein particle clearance (GO:0034381)2.79385214
97detection of external biotic stimulus (GO:0098581)2.77327075
98endocardial cushion development (GO:0003197)2.77249877
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.76762844
100regulation of triglyceride biosynthetic process (GO:0010866)2.76506807
101establishment of apical/basal cell polarity (GO:0035089)2.76307983
102positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.75140348
103adhesion of symbiont to host (GO:0044406)2.74771742
104chemical homeostasis within a tissue (GO:0048875)2.73305401
105antigen processing and presentation of endogenous antigen (GO:0019883)2.73295268
106mannose metabolic process (GO:0006013)2.72761530
107sulfur amino acid catabolic process (GO:0000098)2.71050319
108regulation of T-helper 2 cell differentiation (GO:0045628)2.70468361
109fatty acid transmembrane transport (GO:1902001)2.69696055
110neutrophil activation involved in immune response (GO:0002283)2.68868683
111regulation of triglyceride catabolic process (GO:0010896)2.68580898
112cytoskeletal anchoring at plasma membrane (GO:0007016)2.67846193
113modulation by symbiont of host cellular process (GO:0044068)2.67678381
114angiogenesis involved in wound healing (GO:0060055)2.67221949
115response to laminar fluid shear stress (GO:0034616)2.67136921
116regulation of tolerance induction (GO:0002643)2.66785908
117negative regulation of type 2 immune response (GO:0002829)2.65912258
118tolerance induction (GO:0002507)2.63785661
119basement membrane organization (GO:0071711)2.63567937
120pinocytosis (GO:0006907)2.62682099
121triglyceride metabolic process (GO:0006641)2.62250945
122regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.61907550
123detection of biotic stimulus (GO:0009595)2.61705172
124antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61137046
125heme transport (GO:0015886)2.60466474
126glucose catabolic process (GO:0006007)2.60055466
127regulation of cholesterol storage (GO:0010885)2.60027987
128positive regulation of tolerance induction (GO:0002645)2.59934184
129metanephric nephron tubule development (GO:0072234)2.58738561
130metanephric tubule development (GO:0072170)2.58738561
131positive regulation of lipoprotein lipase activity (GO:0051006)2.58399992
132positive regulation of triglyceride lipase activity (GO:0061365)2.58399992
133L-serine metabolic process (GO:0006563)2.58333470
134cellular response to virus (GO:0098586)2.58186317
135embryonic placenta development (GO:0001892)2.57973843
136cortical cytoskeleton organization (GO:0030865)2.57932643
137short-chain fatty acid metabolic process (GO:0046459)2.55834757
138negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.55716646
139membrane tubulation (GO:0097320)2.55502699
140negative regulation of GTPase activity (GO:0034260)2.55135391
141negative regulation of GTP catabolic process (GO:0033125)2.55135391
142negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55003698
143negative regulation of DNA-templated transcription, elongation (GO:0032785)2.55003698
144mature B cell differentiation (GO:0002335)2.54768497
145negative regulation of toll-like receptor signaling pathway (GO:0034122)2.54560750
146regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.53446143
147regulation of hydrogen peroxide-induced cell death (GO:1903205)2.53083931
148negative regulation of cytokine production involved in immune response (GO:0002719)2.52960860
149negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.52633500
150acylglycerol metabolic process (GO:0006639)2.52539956
151regulation of leukocyte degranulation (GO:0043300)2.51703888
152cranial suture morphogenesis (GO:0060363)2.51508224
153regulation of type 2 immune response (GO:0002828)2.51190444
154positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.50709775
155glycerolipid catabolic process (GO:0046503)2.50365778
156NIK/NF-kappaB signaling (GO:0038061)2.50253137
157antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47947294
158regulation of gamma-delta T cell differentiation (GO:0045586)2.46165701
159cellular response to thyroid hormone stimulus (GO:0097067)2.45880696
160response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.45506418
161response to host (GO:0075136)2.45506418
162response to host defenses (GO:0052200)2.45506418
163regulation of T-helper 1 cell differentiation (GO:0045625)2.45278032
164positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.45132464
165positive regulation of extracellular matrix organization (GO:1903055)2.43378653
166regulation of T cell tolerance induction (GO:0002664)2.42210113
167negative regulation of T cell mediated immunity (GO:0002710)2.42000447
168regulation of necroptotic process (GO:0060544)2.40894128
169myeloid dendritic cell differentiation (GO:0043011)2.40335931
170response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.40224608
171response to host immune response (GO:0052572)2.40224608
172embryonic process involved in female pregnancy (GO:0060136)2.39854540
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.38272940
174defense response to protozoan (GO:0042832)2.37323117
175leukocyte aggregation (GO:0070486)2.36014981
176positive thymic T cell selection (GO:0045059)2.35999761
177positive regulation of Cdc42 GTPase activity (GO:0043089)2.35435097
178regulation of interferon-beta biosynthetic process (GO:0045357)2.34341095
179regulation of early endosome to late endosome transport (GO:2000641)2.33619227
180T cell migration (GO:0072678)2.33064220
181negative regulation of leukocyte mediated immunity (GO:0002704)2.32849790
182positive regulation of type 2 immune response (GO:0002830)2.32619179
183regulation of dendritic cell antigen processing and presentation (GO:0002604)2.31250824
184regulation of myeloid leukocyte mediated immunity (GO:0002886)2.30377347
185regulation of podosome assembly (GO:0071801)2.29591255
186regulation of mast cell degranulation (GO:0043304)2.28119519
187amyloid precursor protein catabolic process (GO:0042987)2.26899338
188immunoglobulin mediated immune response (GO:0016064)2.26696686
189regulation of membrane protein ectodomain proteolysis (GO:0051043)2.26503513
190apoptotic cell clearance (GO:0043277)2.25377855
191skin morphogenesis (GO:0043589)2.24715782

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.54838884
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.89695986
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.00666718
4RXR_22158963_ChIP-Seq_LIVER_Mouse2.67136151
5IRF8_22096565_ChIP-ChIP_GC-B_Human2.66016534
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.48786054
7* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.32817817
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30695984
9LXR_22292898_ChIP-Seq_THP-1_Human2.29531330
10VDR_21846776_ChIP-Seq_THP-1_Human2.28064956
11NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.26290771
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21298253
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.19872179
14FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.17753205
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.15166996
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.15074416
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05883364
18LXR_22158963_ChIP-Seq_LIVER_Mouse2.05528404
19IRF8_21731497_ChIP-ChIP_J774_Mouse2.04754703
20IRF8_27001747_Chip-Seq_BMDM_Mouse2.04556065
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.00187136
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.95009321
23RACK7_27058665_Chip-Seq_MCF-7_Human1.92176594
24KDM2B_26808549_Chip-Seq_DND41_Human1.88819993
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.87239572
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.86731495
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85800827
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.85562955
29SCL_19346495_ChIP-Seq_HPC-7_Human1.81482747
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78413937
31ZNF263_19887448_ChIP-Seq_K562_Human1.73420344
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68857518
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.68034417
34STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66967778
35CLOCK_20551151_ChIP-Seq_293T_Human1.66684547
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.65315866
37GATA1_22025678_ChIP-Seq_K562_Human1.59520670
38KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.57909817
39ZFP281_18757296_ChIP-ChIP_E14_Mouse1.54951145
40STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52889173
41VDR_24763502_ChIP-Seq_THP-1_Human1.52496106
42TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52352260
43RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.52172006
44MYC_22102868_ChIP-Seq_BL_Human1.51496998
45Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51197230
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51073334
47TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50173353
48KDM2B_26808549_Chip-Seq_K562_Human1.49353090
49FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.46668338
50SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46312984
51FOXO3_23340844_ChIP-Seq_DLD1_Human1.41272824
52* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39383086
53NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39362445
54PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38409161
55KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.37947718
56KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.37947718
57KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.37947718
58TCF7_22412390_ChIP-Seq_EML_Mouse1.37796583
59MAF_26560356_Chip-Seq_TH1_Human1.36162229
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34303844
61RUNX_20019798_ChIP-Seq_JUKART_Human1.34076895
62SPI1_23547873_ChIP-Seq_NB4_Human1.33827914
63EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33337826
64IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.33253486
65NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.33183615
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.32961124
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.31137532
68ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29996657
69DNAJC2_21179169_ChIP-ChIP_NT2_Human1.29958610
70SMC4_20622854_ChIP-Seq_HELA_Human1.29413863
71TP53_22127205_ChIP-Seq_IMR90_Human1.28689210
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28198214
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.27464208
74P68_20966046_ChIP-Seq_HELA_Human1.26227244
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.25714497
76* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23758867
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.22801935
78SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.22801096
79NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.22453973
80SPI1_23127762_ChIP-Seq_K562_Human1.22293746
81EGR1_19374776_ChIP-ChIP_THP-1_Human1.21737705
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.21112604
83SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18628971
84BCL6_27268052_Chip-Seq_Bcells_Human1.18248613
85EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16600014
86ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16551419
87SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16368241
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16166563
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15826229
90CTCF_21964334_ChIP-Seq_BJAB-B_Human1.15811469
91CDX2_20551321_ChIP-Seq_CACO-2_Human1.15781150
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.14861317
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.14735642
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13948916
95ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.13898542
96AR_21572438_ChIP-Seq_LNCaP_Human1.13556618
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.13202123
98KDM2B_26808549_Chip-Seq_JURKAT_Human1.12754208
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12167773
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12161078
101NCOR1_26117541_ChIP-Seq_K562_Human1.11946111
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11637384
103BCOR_27268052_Chip-Seq_Bcells_Human1.11579463
104* PU_27001747_Chip-Seq_BMDM_Mouse1.09208596
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08018980
106MAF_26560356_Chip-Seq_TH2_Human1.07988507
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07964842
108MYB_26560356_Chip-Seq_TH1_Human1.07819561
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.07453236
110CREB1_26743006_Chip-Seq_LNCaP_Human1.06732338
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.06214140
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05860286
113PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05673293
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05443588
115* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04242348
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04089038
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.03808614
118MYB_26560356_Chip-Seq_TH2_Human1.03538997
119NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02529452
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02400976
121SPI1_20517297_ChIP-Seq_HL60_Human1.01954477
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.01952651
123UTX_26944678_Chip-Seq_JUKART_Human1.01642558
124MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01588089
125NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.01280927
126FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.00808770
127IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00525102
128TRIM28_21343339_ChIP-Seq_HEK293_Human1.00486102
129GATA1_19941826_ChIP-Seq_K562_Human1.00119177
130DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99167312
131SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99152885
132TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.98416132
133GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98394002
134RUNX1_22412390_ChIP-Seq_EML_Mouse0.98386431
135CTCF_21964334_Chip-Seq_Bcells_Human0.98357415
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.97612729
137UBF1/2_26484160_Chip-Seq_HMECs_Human0.97552767
138ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.97449740
139* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.97435223
140RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96727805
141SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96688986
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.96670731
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95897099
144TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92423789

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract3.47760081
2MP0003191_abnormal_cellular_cholesterol3.29235020
3MP0003436_decreased_susceptibility_to3.03570624
4MP0005451_abnormal_body_composition3.01785180
5MP0001348_abnormal_lacrimal_gland2.68248998
6MP0004185_abnormal_adipocyte_glucose2.63209771
7MP0001958_emphysema2.57692253
8MP0005623_abnormal_meninges_morphology2.48379468
9MP0008260_abnormal_autophagy2.47226622
10MP0005167_abnormal_blood-brain_barrier2.45584895
11MP0000537_abnormal_urethra_morphology2.45017706
12MP0009840_abnormal_foam_cell2.44214878
13MP0008438_abnormal_cutaneous_collagen2.37865794
14MP0003690_abnormal_glial_cell2.28906310
15MP0003303_peritoneal_inflammation2.28422643
16MP0000920_abnormal_myelination2.20266121
17MP0003123_paternal_imprinting2.18899809
18MP0004782_abnormal_surfactant_physiolog2.17940340
19MP0003045_fibrosis2.16259337
20MP0003705_abnormal_hypodermis_morpholog2.08924807
21MP0003329_amyloid_beta_deposits2.06747388
22MP0002419_abnormal_innate_immunity2.06467864
23MP0002139_abnormal_hepatobiliary_system2.00274412
24MP0000685_abnormal_immune_system1.99737320
25MP0010329_abnormal_lipoprotein_level1.96075459
26MP0005666_abnormal_adipose_tissue1.92213233
27MP0004272_abnormal_basement_membrane1.87063888
28MP0003172_abnormal_lysosome_physiology1.82504444
29MP0004947_skin_inflammation1.82152911
30MP0000858_altered_metastatic_potential1.80429629
31MP0005000_abnormal_immune_tolerance1.77743729
32MP0003279_aneurysm1.77713134
33MP0003252_abnormal_bile_duct1.75406509
34MP0002118_abnormal_lipid_homeostasis1.75095140
35MP0004130_abnormal_muscle_cell1.74552850
36MP0005375_adipose_tissue_phenotype1.74280234
37MP0002148_abnormal_hypersensitivity_rea1.72251020
38MP0009785_altered_susceptibility_to1.70351367
39MP0009333_abnormal_splenocyte_physiolog1.67215534
40MP0000003_abnormal_adipose_tissue1.65723254
41MP0005360_urolithiasis1.64874826
42MP0001533_abnormal_skeleton_physiology1.64702278
43MP0005076_abnormal_cell_differentiation1.63949505
44MP0000604_amyloidosis1.63139038
45MP0005085_abnormal_gallbladder_physiolo1.57747795
46MP0001881_abnormal_mammary_gland1.57499857
47MP0002998_abnormal_bone_remodeling1.57177899
48MP0002452_abnormal_antigen_presenting1.56485683
49MP0003763_abnormal_thymus_physiology1.54996644
50MP0002877_abnormal_melanocyte_morpholog1.54950971
51MP0001800_abnormal_humoral_immune1.54596340
52MP0002723_abnormal_immune_serum1.51335292
53MP0003566_abnormal_cell_adhesion1.49224847
54MP0004858_abnormal_nervous_system1.47271095
55MP0001819_abnormal_immune_cell1.42271526
56MP0002295_abnormal_pulmonary_circulatio1.42233324
57MP0002420_abnormal_adaptive_immunity1.42148388
58MP0005670_abnormal_white_adipose1.41293677
59MP0002405_respiratory_system_inflammati1.38965666
60MP0005584_abnormal_enzyme/coenzyme_acti1.35515343
61MP0003300_gastrointestinal_ulcer1.35346106
62MP0003075_altered_response_to1.34999987
63MP0009384_cardiac_valve_regurgitation1.34177123
64MP0003806_abnormal_nucleotide_metabolis1.33725060
65MP0001849_ear_inflammation1.32931156
66MP0005388_respiratory_system_phenotype1.28156214
67MP0002133_abnormal_respiratory_system1.28156214
68MP0000747_muscle_weakness1.27086306
69MP0009278_abnormal_bone_marrow1.25469169
70MP0002332_abnormal_exercise_endurance1.23686664
71MP0002138_abnormal_hepatobiliary_system1.22465667
72MP0005058_abnormal_lysosome_morphology1.20865624
73MP0001835_abnormal_antigen_presentation1.19655778
74MP0005332_abnormal_amino_acid1.19606305
75MP0004808_abnormal_hematopoietic_stem1.19428378
76MP0002398_abnormal_bone_marrow1.18342085
77MP0009764_decreased_sensitivity_to1.18290294
78MP0001177_atelectasis1.18058268
79MP0005330_cardiomyopathy1.17358832
80MP0010352_gastrointestinal_tract_polyps1.17100229
81MP0010155_abnormal_intestine_physiology1.16203652
82MP0010678_abnormal_skin_adnexa1.16005598
83MP0005671_abnormal_response_to1.15332157
84MP0003453_abnormal_keratinocyte_physiol1.14712237
85MP0005023_abnormal_wound_healing1.13851824
86MP0001851_eye_inflammation1.13320619
87MP0004510_myositis1.13070085
88MP0001915_intracranial_hemorrhage1.13010234
89MP0005397_hematopoietic_system_phenotyp1.11415652
90MP0001545_abnormal_hematopoietic_system1.11415652
91MP0001346_abnormal_lacrimal_gland1.11188631
92MP0000716_abnormal_immune_system1.11113934
93MP0000609_abnormal_liver_physiology1.10625718
94MP0003656_abnormal_erythrocyte_physiolo1.10409651
95MP0005409_darkened_coat_color1.10181435
96MP0001845_abnormal_inflammatory_respons1.09533415
97MP0008469_abnormal_protein_level1.08477504
98MP0000465_gastrointestinal_hemorrhage1.08121617
99MP0002971_abnormal_brown_adipose1.07831912
100MP0000343_altered_response_to1.07736840
101MP0005257_abnormal_intraocular_pressure1.07139297
102MP0004233_abnormal_muscle_weight1.06058427
103MP0003632_abnormal_nervous_system1.04553576
104MP0000733_abnormal_muscle_development1.04050710
105MP0002254_reproductive_system_inflammat1.03448447
106MP0008875_abnormal_xenobiotic_pharmacok1.01118325
107MP0003828_pulmonary_edema1.00897196
108MP0004142_abnormal_muscle_tone1.00732699
109MP0003638_abnormal_response/metabolism_0.98979655
110MP0002722_abnormal_immune_system0.97678149
111MP0001666_abnormal_nutrient_absorption0.97661955
112MP0001853_heart_inflammation0.97514581
113MP0002269_muscular_atrophy0.97354721
114MP0005164_abnormal_response_to0.96969091
115MP0000249_abnormal_blood_vessel0.96695822
116MP0004883_abnormal_blood_vessel0.96011385
117MP0002168_other_aberrant_phenotype0.94670346
118MP0005365_abnormal_bile_salt0.94017428
119MP0005464_abnormal_platelet_physiology0.93253403
120MP0002429_abnormal_blood_cell0.92642639
121MP0002928_abnormal_bile_duct0.91147945
122MP0000689_abnormal_spleen_morphology0.90961201
123MP0005390_skeleton_phenotype0.90252513
124MP0000767_abnormal_smooth_muscle0.88892199
125MP0003091_abnormal_cell_migration0.88548274
126MP0003724_increased_susceptibility_to0.87521692
127MP0000759_abnormal_skeletal_muscle0.86060088
128MP0000703_abnormal_thymus_morphology0.85638978
129MP0008874_decreased_physiological_sensi0.84872761
130MP0005621_abnormal_cell_physiology0.84798187
131MP0000751_myopathy0.83553760
132MP0004885_abnormal_endolymph0.83545603
133MP0001542_abnormal_bone_strength0.82323912
134MP0006054_spinal_hemorrhage0.81704367
135MP0009763_increased_sensitivity_to0.78167658
136MP0003448_altered_tumor_morphology0.77660530
137MP0008004_abnormal_stomach_pH0.75425091
138MP0000383_abnormal_hair_follicle0.73704671
139MP0003634_abnormal_glial_cell0.73633072
140MP0010630_abnormal_cardiac_muscle0.72846551
141MP0002970_abnormal_white_adipose0.70074312
142MP0010368_abnormal_lymphatic_system0.69152936
143MP0003631_nervous_system_phenotype0.68835644
144MP0003633_abnormal_nervous_system0.68319802
145MP0008775_abnormal_heart_ventricle0.67241537
146MP0005387_immune_system_phenotype0.67000425
147MP0001790_abnormal_immune_system0.67000425
148MP0005025_abnormal_response_to0.66676376
149MP0008770_decreased_survivor_rate0.66061432
150MP0000598_abnormal_liver_morphology0.65488234
151MP0001614_abnormal_blood_vessel0.63993859
152MP0008873_increased_physiological_sensi0.63759737
153MP0004147_increased_porphyrin_level0.63513340
154MP0006082_CNS_inflammation0.60820175

Predicted human phenotypes

RankGene SetZ-score
1Cerebral aneurysm (HP:0004944)5.90431941
2Interstitial pulmonary disease (HP:0006530)5.10481483
3Scanning speech (HP:0002168)4.08888360
4Neurofibrillary tangles (HP:0002185)3.79840085
5Ragged-red muscle fibers (HP:0003200)3.48911293
6Eczematoid dermatitis (HP:0000976)3.46829202
7Hyperlipoproteinemia (HP:0010980)3.32947586
8Cerebral inclusion bodies (HP:0100314)3.32632775
9Progressive muscle weakness (HP:0003323)3.24114091
10Broad metatarsal (HP:0001783)3.23239398
11Deep venous thrombosis (HP:0002625)3.21690157
12Supranuclear gaze palsy (HP:0000605)3.21641037
13Recurrent bacterial skin infections (HP:0005406)3.17258382
14Recurrent abscess formation (HP:0002722)3.12474242
15Overriding aorta (HP:0002623)3.10626446
16Subacute progressive viral hepatitis (HP:0006572)3.04767141
17Abnormality of macrophages (HP:0004311)2.93297224
18Ulnar bowing (HP:0003031)2.93073350
19Loss of speech (HP:0002371)2.91988841
20Achilles tendon contracture (HP:0001771)2.81687900
21Abnormality of the Achilles tendon (HP:0005109)2.79131129
22Spastic paraparesis (HP:0002313)2.77262513
23Recurrent gram-negative bacterial infections (HP:0005420)2.75906767
24Hemiplegia (HP:0002301)2.74033608
25Shallow orbits (HP:0000586)2.71973652
26Systemic lupus erythematosus (HP:0002725)2.70917408
27Myositis (HP:0100614)2.67549336
28Turricephaly (HP:0000262)2.66802004
29Type 1 muscle fiber predominance (HP:0003803)2.64142843
30Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62659647
31Abnormality of the nasal mucosa (HP:0000433)2.61184302
32Nasal polyposis (HP:0100582)2.60107770
33Tachypnea (HP:0002789)2.57683075
34Xanthomatosis (HP:0000991)2.57297568
35Orchitis (HP:0100796)2.55791884
36Vertebral compression fractures (HP:0002953)2.53145105
37Delayed CNS myelination (HP:0002188)2.52348760
38Abnormality of skeletal muscle fiber size (HP:0012084)2.52264260
39Increased serum ferritin (HP:0003281)2.50346481
40Bowel diverticulosis (HP:0005222)2.46391359
41Centrally nucleated skeletal muscle fibers (HP:0003687)2.46379480
42Exercise-induced myalgia (HP:0003738)2.42995452
43Increased variability in muscle fiber diameter (HP:0003557)2.42302565
44Segmental peripheral demyelination/remyelination (HP:0003481)2.38895870
45Amyloidosis (HP:0011034)2.38258244
46Coronal craniosynostosis (HP:0004440)2.34065566
47Infantile muscular hypotonia (HP:0008947)2.33450937
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.31925890
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.31925890
50Dysostosis multiplex (HP:0000943)2.31378308
51Increased connective tissue (HP:0009025)2.31272205
52Optic neuritis (HP:0100653)2.30889191
53Retrobulbar optic neuritis (HP:0100654)2.30889191
54Slow saccadic eye movements (HP:0000514)2.30660028
55Cellulitis (HP:0100658)2.29250733
56Sensory axonal neuropathy (HP:0003390)2.28810145
57Purpura (HP:0000979)2.28460131
58Gingivitis (HP:0000230)2.26072138
59Muscle fiber inclusion bodies (HP:0100299)2.25562269
60Glomerulosclerosis (HP:0000096)2.24777730
61Nemaline bodies (HP:0003798)2.24661437
62Partial duplication of thumb phalanx (HP:0009944)2.23858836
63Premature skin wrinkling (HP:0100678)2.21034541
64Distal lower limb muscle weakness (HP:0009053)2.20203517
65Abnormality of the periventricular white matter (HP:0002518)2.19505735
66Bowed forearm bones (HP:0003956)2.18591431
67Bowing of the arm (HP:0006488)2.18591431
68Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.17651320
69Plagiocephaly (HP:0001357)2.15985588
70Asymmetric septal hypertrophy (HP:0001670)2.14373868
71Abnormality of serine family amino acid metabolism (HP:0010894)2.13907974
72Abnormality of glycine metabolism (HP:0010895)2.13907974
73Abnormality of the corticospinal tract (HP:0002492)2.13649664
74Abnormality of the salivary glands (HP:0010286)2.13513595
75Myocardial infarction (HP:0001658)2.13446065
76Partial duplication of the phalanx of hand (HP:0009999)2.13338178
77Increased cerebral lipofuscin (HP:0011813)2.12071539
78Peritonitis (HP:0002586)2.11876248
79Micronodular cirrhosis (HP:0001413)2.11128343
80Difficulty running (HP:0009046)2.10700963
81Thoracic kyphosis (HP:0002942)2.10559065
82Stomach cancer (HP:0012126)2.10052678
83Mediastinal lymphadenopathy (HP:0100721)2.09732739
84Stridor (HP:0010307)2.09673272
85Mitral valve prolapse (HP:0001634)2.09174167
86Cervical subluxation (HP:0003308)2.08411028
87Intention tremor (HP:0002080)2.08242798
88Polygenic inheritance (HP:0010982)2.08236886
89Upper motor neuron abnormality (HP:0002127)2.08114275
90Resting tremor (HP:0002322)2.07161038
91Spontaneous hematomas (HP:0007420)2.05949520
92Spondylolisthesis (HP:0003302)2.05654653
93Abnormality of glycolipid metabolism (HP:0010969)2.04156128
94Abnormality of liposaccharide metabolism (HP:0010968)2.04156128
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.04156128
96Paraparesis (HP:0002385)2.03033584
97Aneurysm (HP:0002617)2.02906397
98Macroorchidism (HP:0000053)2.02188878
99Postural instability (HP:0002172)2.01084176
100Hepatocellular carcinoma (HP:0001402)1.99435345
101Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98592549
102Spastic gait (HP:0002064)1.97918279
103Hyperacusis (HP:0010780)1.97877376
104Abnormality of complement system (HP:0005339)1.96362640
105Muscle fiber splitting (HP:0003555)1.96183915
106Genu recurvatum (HP:0002816)1.95337611
107Recurrent viral infections (HP:0004429)1.95026785
108Intrahepatic cholestasis (HP:0001406)1.94227580
109Protrusio acetabuli (HP:0003179)1.94227545
110Dilatation of the ascending aorta (HP:0005111)1.94216150
111Thin bony cortex (HP:0002753)1.94081609
112Gingival bleeding (HP:0000225)1.94024299
113Spastic diplegia (HP:0001264)1.93976838
114Cerebral hypomyelination (HP:0006808)1.93917499
115Chronic otitis media (HP:0000389)1.93432176
116Hypokinesia (HP:0002375)1.92876812
117Ulnar deviation of the wrist (HP:0003049)1.91475947
118Termporal pattern (HP:0011008)1.91196691
119Insidious onset (HP:0003587)1.91196691
120Rapidly progressive (HP:0003678)1.90875551
121Gastrointestinal infarctions (HP:0005244)1.90381791
122Myoglobinuria (HP:0002913)1.90120462
123Polycythemia (HP:0001901)1.90032429
124Premature rupture of membranes (HP:0001788)1.89795259
125Axonal loss (HP:0003447)1.89710005
126Recurrent skin infections (HP:0001581)1.89099533
127Respiratory distress (HP:0002098)1.88665473
128Abnormality of the thoracic spine (HP:0100711)1.88238869
129Spinal rigidity (HP:0003306)1.88061887
130Epidermoid cyst (HP:0200040)1.87408167
131Arnold-Chiari malformation (HP:0002308)1.87192674
132Hemorrhage of the eye (HP:0011885)1.85639978
133Clonus (HP:0002169)1.85615560
134Anteriorly placed anus (HP:0001545)1.84614893
135Blue sclerae (HP:0000592)1.84222592
136Vacuolated lymphocytes (HP:0001922)1.83816845
137Disproportionate tall stature (HP:0001519)1.82315111
138Spinal cord lesions (HP:0100561)1.82181172
139Syringomyelia (HP:0003396)1.82181172
140Gout (HP:0001997)1.81704848
141Complement deficiency (HP:0004431)1.80790452
142Viral hepatitis (HP:0006562)1.80226631
143Clumsiness (HP:0002312)1.80078279
144Slender build (HP:0001533)1.79492208
145Short nail (HP:0001799)1.78032762
146Flat acetabular roof (HP:0003180)1.78029025
147Abnormality of the peritoneum (HP:0002585)1.78026498
148Vascular tortuosity (HP:0004948)1.76320434
149Distal lower limb amyotrophy (HP:0008944)1.75120472
150Back pain (HP:0003418)1.75078357
151Arterial thrombosis (HP:0004420)1.74856475
152Abnormality of iron homeostasis (HP:0011031)1.74679205
153Megalencephaly (HP:0001355)1.74463038
154Atrophic scars (HP:0001075)1.74305278
155Metaphyseal cupping (HP:0003021)1.74264881
156Insomnia (HP:0100785)1.73901579
157Hyperglycinuria (HP:0003108)1.73514968
158Ankle contracture (HP:0006466)1.73272778
159Osteolytic defects of the hand bones (HP:0009699)1.72090923
160Osteolytic defects of the phalanges of the hand (HP:0009771)1.72090923
161Buphthalmos (HP:0000557)1.71769512
162Annular pancreas (HP:0001734)1.71583229
163Elevated erythrocyte sedimentation rate (HP:0003565)1.71435107
164Obstructive lung disease (HP:0006536)1.70914705
165Chronic obstructive pulmonary disease (HP:0006510)1.70914705
166Meningitis (HP:0001287)1.70115457
167Nuclear cataract (HP:0100018)1.69775647
168Glomerulonephritis (HP:0000099)1.69462452
169Urinary glycosaminoglycan excretion (HP:0003541)1.69352504
170Mucopolysacchariduria (HP:0008155)1.69352504
171Stomatitis (HP:0010280)1.69123320
172Keratoconjunctivitis sicca (HP:0001097)1.67262406
173T lymphocytopenia (HP:0005403)1.66760963
174Difficulty climbing stairs (HP:0003551)1.66731637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.89452180
2TRIB33.36637761
3BCKDK3.10594836
4SMG12.97348734
5ERN12.93371886
6MAP2K32.72258194
7ICK2.65198437
8EPHB12.52572005
9STK392.38274723
10LRRK22.15584169
11SIK12.11808283
12MATK2.09339091
13MAP3K101.97997750
14MAP3K141.95941049
15RIPK41.95651772
16BLK1.93686762
17CDK121.91677415
18MAP3K91.88968797
19BMX1.82614278
20FGFR21.75542409
21TIE11.74971080
22PRKCH1.73324100
23MET1.72110877
24CAMK1D1.69248100
25TAOK21.64257900
26NTRK11.63413404
27TYRO31.60478972
28CAMK1G1.51489885
29PKN21.51402014
30IRAK41.49966477
31RIPK11.44994753
32ZAK1.41906822
33MAP3K31.39871172
34SCYL21.38986673
35KSR21.38626964
36MAP3K111.34304802
37DDR21.32176097
38ALK1.29789687
39CSK1.28009368
40CDK191.27713127
41TAOK11.22121090
42MOS1.20789348
43CDC42BPA1.17480970
44PRKD21.16958083
45MAP4K11.16787323
46FES1.14656954
47MAP3K61.14012690
48MAP3K81.14003565
49STK101.13057601
50MAP3K11.12092873
51TTN1.10482489
52HIPK21.08479870
53CSF1R1.08292261
54NEK91.08167170
55WNK11.07739613
56OXSR11.06202555
57TGFBR21.04255455
58PTK61.01247368
59MAPK120.98787998
60PAK40.97434115
61IKBKE0.97177728
62MST1R0.95782136
63PAK20.94944202
64EPHA20.92348524
65GRK60.92319912
66PDPK10.91178469
67MAPK70.91124309
68PRKD10.88178994
69FGR0.85752206
70ABL20.85634491
71TYK20.85185528
72DAPK20.83156686
73ILK0.82718907
74ROCK20.82284539
75ARAF0.81625180
76LMTK20.81258538
77GSK3A0.80396396
78LATS20.79632331
79PKN10.78732368
80SIK20.75570700
81GRK70.74932851
82FGFR40.73998465
83DAPK30.72796230
84TBK10.71478527
85JAK30.70677893
86PDGFRA0.70676134
87IRAK30.69803891
88JAK20.68917113
89TNK20.67721950
90RPS6KA20.67378878
91EEF2K0.67105510
92DYRK1B0.66024035
93PIK3CG0.65850945
94ZAP700.64332481
95MAP3K130.63340642
96RPS6KL10.62928109
97RPS6KC10.62928109
98CDK90.62478401
99HCK0.61784286
100FGFR30.60877708
101TGFBR10.59867086
102LCK0.59839566
103CDK40.58852657
104STK110.58331892
105CSNK1G10.58148483
106DMPK0.57786717
107MAP3K70.56545273
108TTK0.56161132
109PRKCQ0.55645514
110CSNK1G30.55563010
111STK240.53928811
112CLK10.53772180
113RET0.53600427
114OBSCN0.52597596
115UHMK10.51508194
116IRAK20.51137952
117CAMK2G0.50690486
118NME20.50633512
119SYK0.50456712
120PAK30.50149178
121MARK20.50020194
122LATS10.49537233
123PDK10.49149032
124JAK10.48916518
125MELK0.47447068
126CDK60.47316824
127MAP3K50.47052503
128MAPK110.46215122
129MAP2K20.45035366
130MAP2K40.44186312
131MTOR0.44117736
132LYN0.43798577
133CAMK10.43675968
134BTK0.43606111
135MAP3K20.42772541
136PDGFRB0.42766085
137INSR0.41792947
138ABL10.40851312
139RAF10.39971351
140WNK40.39621082
141PRKAA20.39306675
142STK380.39252820
143KIT0.38463757
144IRAK10.38434593
145CDK140.38332096

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.09662606
2Vitamin B6 metabolism_Homo sapiens_hsa007503.63328337
3Fatty acid biosynthesis_Homo sapiens_hsa000613.60861411
4Fatty acid elongation_Homo sapiens_hsa000622.89199688
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.72334997
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.71946143
7Fatty acid metabolism_Homo sapiens_hsa012122.60236818
8Caffeine metabolism_Homo sapiens_hsa002322.48280407
9Osteoclast differentiation_Homo sapiens_hsa043802.35707429
10Other glycan degradation_Homo sapiens_hsa005112.27379131
11Propanoate metabolism_Homo sapiens_hsa006402.16775785
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12285529
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.06475657
14Primary bile acid biosynthesis_Homo sapiens_hsa001202.04830153
15PPAR signaling pathway_Homo sapiens_hsa033202.02493918
16Tryptophan metabolism_Homo sapiens_hsa003802.01816731
17Leishmaniasis_Homo sapiens_hsa051401.98140882
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.82530639
19Arginine biosynthesis_Homo sapiens_hsa002201.80707014
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.77419955
21Fatty acid degradation_Homo sapiens_hsa000711.76994235
22RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.63313104
23TNF signaling pathway_Homo sapiens_hsa046681.58689773
24Toxoplasmosis_Homo sapiens_hsa051451.48421945
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.48136345
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48108775
27Influenza A_Homo sapiens_hsa051641.46738238
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.45501740
29Tuberculosis_Homo sapiens_hsa051521.45154899
30Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.43999367
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42134903
32Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41323268
33Measles_Homo sapiens_hsa051621.41091387
34Pancreatic cancer_Homo sapiens_hsa052121.41079505
35Pertussis_Homo sapiens_hsa051331.39913355
36Hepatitis B_Homo sapiens_hsa051611.35566611
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32920938
38Butanoate metabolism_Homo sapiens_hsa006501.31864858
39Basal cell carcinoma_Homo sapiens_hsa052171.29573870
40Complement and coagulation cascades_Homo sapiens_hsa046101.29518853
41Prolactin signaling pathway_Homo sapiens_hsa049171.28169538
42Hepatitis C_Homo sapiens_hsa051601.27160210
43NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24082002
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.22707910
45T cell receptor signaling pathway_Homo sapiens_hsa046601.22453140
46Glycosaminoglycan degradation_Homo sapiens_hsa005311.22129386
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.19299713
48Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.17902549
49Apoptosis_Homo sapiens_hsa042101.17519810
50beta-Alanine metabolism_Homo sapiens_hsa004101.17163024
51Sulfur relay system_Homo sapiens_hsa041221.16657883
52ECM-receptor interaction_Homo sapiens_hsa045121.09392223
53Pentose phosphate pathway_Homo sapiens_hsa000301.08321790
54Lysosome_Homo sapiens_hsa041421.07784399
55ABC transporters_Homo sapiens_hsa020101.07295241
56Salmonella infection_Homo sapiens_hsa051321.07188456
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.06833987
58Herpes simplex infection_Homo sapiens_hsa051681.06655628
59Steroid biosynthesis_Homo sapiens_hsa001001.04748788
60Legionellosis_Homo sapiens_hsa051341.04573869
61Hematopoietic cell lineage_Homo sapiens_hsa046401.03620305
62Bile secretion_Homo sapiens_hsa049761.03326741
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03044154
64Viral myocarditis_Homo sapiens_hsa054161.02911315
65Histidine metabolism_Homo sapiens_hsa003401.01254369
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.00381050
67Folate biosynthesis_Homo sapiens_hsa007900.98690023
68Endometrial cancer_Homo sapiens_hsa052130.98454253
69Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97430088
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.96501804
71Glycerolipid metabolism_Homo sapiens_hsa005610.95053868
72Staphylococcus aureus infection_Homo sapiens_hsa051500.94375640
73Insulin signaling pathway_Homo sapiens_hsa049100.92188468
74Phagosome_Homo sapiens_hsa041450.90326821
75Renal cell carcinoma_Homo sapiens_hsa052110.90168927
76Carbon metabolism_Homo sapiens_hsa012000.89458847
77Colorectal cancer_Homo sapiens_hsa052100.89135328
78Arginine and proline metabolism_Homo sapiens_hsa003300.88275628
79Hippo signaling pathway_Homo sapiens_hsa043900.88094458
80Thyroid cancer_Homo sapiens_hsa052160.87806017
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87783371
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.87451987
83HTLV-I infection_Homo sapiens_hsa051660.86894896
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.85728257
85Allograft rejection_Homo sapiens_hsa053300.84970635
86B cell receptor signaling pathway_Homo sapiens_hsa046620.83691979
87mTOR signaling pathway_Homo sapiens_hsa041500.83341530
88Proteoglycans in cancer_Homo sapiens_hsa052050.82475425
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81997750
90Prostate cancer_Homo sapiens_hsa052150.81648043
91Platelet activation_Homo sapiens_hsa046110.80214640
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78240416
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.77442794
94Malaria_Homo sapiens_hsa051440.77029261
95Viral carcinogenesis_Homo sapiens_hsa052030.76355373
96Peroxisome_Homo sapiens_hsa041460.76343193
97African trypanosomiasis_Homo sapiens_hsa051430.76246939
98GnRH signaling pathway_Homo sapiens_hsa049120.76018789
99Amoebiasis_Homo sapiens_hsa051460.75331425
100Dorso-ventral axis formation_Homo sapiens_hsa043200.74627983
101Inositol phosphate metabolism_Homo sapiens_hsa005620.71564740
102Autoimmune thyroid disease_Homo sapiens_hsa053200.70881157
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69709500
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.69558564
105MicroRNAs in cancer_Homo sapiens_hsa052060.68651696
106Endocytosis_Homo sapiens_hsa041440.68056903
107Biosynthesis of amino acids_Homo sapiens_hsa012300.67873237
108Focal adhesion_Homo sapiens_hsa045100.66793239
109Antigen processing and presentation_Homo sapiens_hsa046120.66755036
110Type II diabetes mellitus_Homo sapiens_hsa049300.66149411
111Lysine degradation_Homo sapiens_hsa003100.64592336
112Graft-versus-host disease_Homo sapiens_hsa053320.64448473
113Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63279693
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62574700
115Epstein-Barr virus infection_Homo sapiens_hsa051690.62296490
116Glioma_Homo sapiens_hsa052140.61971878
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61872361
118FoxO signaling pathway_Homo sapiens_hsa040680.61326620
119Shigellosis_Homo sapiens_hsa051310.60224032
120Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60188603
121VEGF signaling pathway_Homo sapiens_hsa043700.60126311
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59625011
123Rheumatoid arthritis_Homo sapiens_hsa053230.59531912
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59049961
125Bladder cancer_Homo sapiens_hsa052190.58973578
126Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58586588
127Notch signaling pathway_Homo sapiens_hsa043300.58422134
128Adherens junction_Homo sapiens_hsa045200.58029345
129HIF-1 signaling pathway_Homo sapiens_hsa040660.56694441
130Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55436551
131Choline metabolism in cancer_Homo sapiens_hsa052310.55381283
132Melanogenesis_Homo sapiens_hsa049160.53991641
133Small cell lung cancer_Homo sapiens_hsa052220.52116172
134AMPK signaling pathway_Homo sapiens_hsa041520.51282964
135Chronic myeloid leukemia_Homo sapiens_hsa052200.51173650
136Glycerophospholipid metabolism_Homo sapiens_hsa005640.49576145
137Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49502093
138Leukocyte transendothelial migration_Homo sapiens_hsa046700.48867115
139Hedgehog signaling pathway_Homo sapiens_hsa043400.47703783
140ErbB signaling pathway_Homo sapiens_hsa040120.46530433
141Tight junction_Homo sapiens_hsa045300.46359220
142One carbon pool by folate_Homo sapiens_hsa006700.44053718
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42466438
144Insulin resistance_Homo sapiens_hsa049310.40967564
145Non-small cell lung cancer_Homo sapiens_hsa052230.40921478
146Acute myeloid leukemia_Homo sapiens_hsa052210.40524259
147Ras signaling pathway_Homo sapiens_hsa040140.39656159
148Central carbon metabolism in cancer_Homo sapiens_hsa052300.39648430
149Gap junction_Homo sapiens_hsa045400.38386718
150Pathways in cancer_Homo sapiens_hsa052000.37797881
151Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37214984
152Neurotrophin signaling pathway_Homo sapiens_hsa047220.37006345
153Tyrosine metabolism_Homo sapiens_hsa003500.35058576
154Chemokine signaling pathway_Homo sapiens_hsa040620.34868166
155Rap1 signaling pathway_Homo sapiens_hsa040150.34691735
156Ether lipid metabolism_Homo sapiens_hsa005650.33950128
157Salivary secretion_Homo sapiens_hsa049700.33766273
158Phenylalanine metabolism_Homo sapiens_hsa003600.33356958
159Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.29019027
160Prion diseases_Homo sapiens_hsa050200.29008917
161Chemical carcinogenesis_Homo sapiens_hsa052040.28599715
162MAPK signaling pathway_Homo sapiens_hsa040100.28512502

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