TMEM110-MUSTN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This locus represents naturally occurring read-through transcription between the neighboring TMEM110 (transmembrane protein 110) and MUSTN1 (musculoskeletal, embryonic nuclear protein 1) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.84966175
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.68577508
3negative regulation of cell killing (GO:0031342)5.68577508
4tolerance induction (GO:0002507)4.94281738
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.54287139
6regulation of gamma-delta T cell activation (GO:0046643)4.52476593
7antigen processing and presentation of endogenous antigen (GO:0019883)4.42821187
8detection of other organism (GO:0098543)4.38607189
9modulation by symbiont of host defense response (GO:0052031)4.35413747
10modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.35413747
11modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.35413747
12positive regulation by organism of defense response of other organism involved in symbiotic interact4.35413747
13modulation by symbiont of host immune response (GO:0052553)4.35413747
14positive regulation by symbiont of host defense response (GO:0052509)4.35413747
15antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.34920387
16response to peptidoglycan (GO:0032494)4.32098969
17detection of bacterium (GO:0016045)4.28816041
18leukocyte aggregation (GO:0070486)4.28684907
19negative regulation of erythrocyte differentiation (GO:0045647)4.25732457
20positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.13090114
21negative regulation of lymphocyte mediated immunity (GO:0002707)4.09209703
22regulation of gamma-delta T cell differentiation (GO:0045586)4.09073445
23positive regulation of tolerance induction (GO:0002645)4.02601466
24regulation of B cell receptor signaling pathway (GO:0050855)4.01208500
25negative regulation of interleukin-12 production (GO:0032695)3.99139492
26regulation of tolerance induction (GO:0002643)3.97681205
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.96296287
28neutrophil activation involved in immune response (GO:0002283)3.94345349
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.91398614
30negative regulation of T cell mediated immunity (GO:0002710)3.86841154
31cellular extravasation (GO:0045123)3.85568694
32response to muramyl dipeptide (GO:0032495)3.84655300
33macrophage activation involved in immune response (GO:0002281)3.77897995
34negative thymic T cell selection (GO:0045060)3.74840039
35positive thymic T cell selection (GO:0045059)3.73682940
36germinal center formation (GO:0002467)3.61571683
37negative T cell selection (GO:0043383)3.61387044
38negative regulation of leukocyte mediated immunity (GO:0002704)3.55126493
39type I interferon signaling pathway (GO:0060337)3.50925503
40cellular response to type I interferon (GO:0071357)3.50925503
41response to type I interferon (GO:0034340)3.48985261
42detection of external biotic stimulus (GO:0098581)3.45159493
43positive regulation of cellular amide metabolic process (GO:0034250)3.44619687
44negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.43986484
45immunoglobulin mediated immune response (GO:0016064)3.41611903
46regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.38834142
47B cell receptor signaling pathway (GO:0050853)3.38280265
48regulation of T cell tolerance induction (GO:0002664)3.38021474
49positive regulation of B cell differentiation (GO:0045579)3.37974868
50negative regulation of T-helper cell differentiation (GO:0045623)3.31188590
51negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.31188590
52T cell migration (GO:0072678)3.30936188
53response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.29676129
54response to host immune response (GO:0052572)3.29676129
55T cell selection (GO:0045058)3.28456895
56regulation of T-helper 2 cell differentiation (GO:0045628)3.24080433
57positive T cell selection (GO:0043368)3.22022892
58thymic T cell selection (GO:0045061)3.21661413
59response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.18014981
60response to host (GO:0075136)3.18014981
61response to host defenses (GO:0052200)3.18014981
62negative regulation of type 2 immune response (GO:0002829)3.17944458
63negative regulation of interleukin-6 production (GO:0032715)3.13314740
64negative regulation of cytokine production involved in immune response (GO:0002719)3.10703614
65defense response to protozoan (GO:0042832)3.10076633
66detection of biotic stimulus (GO:0009595)3.09002187
67regulation of B cell differentiation (GO:0045577)3.07906391
68response to interleukin-15 (GO:0070672)3.06152541
69negative regulation of B cell mediated immunity (GO:0002713)3.05702637
70negative regulation of immunoglobulin mediated immune response (GO:0002890)3.05702637
71neutrophil activation (GO:0042119)3.05500575
72negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.04956946
73negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.02015521
74positive regulation of granulocyte differentiation (GO:0030854)3.01999905
75detection of molecule of bacterial origin (GO:0032490)3.00801247
76activated T cell proliferation (GO:0050798)2.99920097
77myeloid cell activation involved in immune response (GO:0002275)2.99712295
78regulation of interferon-beta biosynthetic process (GO:0045357)2.99640626
79histone H3-K36 demethylation (GO:0070544)2.99063518
80regulation of alpha-beta T cell proliferation (GO:0046640)2.98264077
81respiratory burst (GO:0045730)2.98063180
82regulation of germinal center formation (GO:0002634)2.98050023
83microglial cell activation (GO:0001774)2.97679779
84JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.95599495
85regulation of T-helper 1 cell differentiation (GO:0045625)2.93750959
86negative regulation of adaptive immune response (GO:0002820)2.92893775
87regulation of regulatory T cell differentiation (GO:0045589)2.91764141
88regulation of interleukin-2 biosynthetic process (GO:0045076)2.90994572
89response to protozoan (GO:0001562)2.90099022
90granulocyte activation (GO:0036230)2.89739344
91positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88237300
92negative regulation of innate immune response (GO:0045824)2.84968302
93macrophage activation (GO:0042116)2.84273056
94regulation of dendritic cell antigen processing and presentation (GO:0002604)2.82743984
95production of molecular mediator involved in inflammatory response (GO:0002532)2.82379737
96regulation of mast cell degranulation (GO:0043304)2.80956749
97Peyers patch development (GO:0048541)2.80665948
98mucosal-associated lymphoid tissue development (GO:0048537)2.80665948
99B cell mediated immunity (GO:0019724)2.76705940
100regulation of necroptotic process (GO:0060544)2.76472192

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.09959281
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.31784171
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.10025983
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.01983511
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.19728150
6VDR_21846776_ChIP-Seq_THP-1_Human3.01522478
7IRF8_21731497_ChIP-ChIP_J774_Mouse2.99986049
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.97618314
9RUNX_20019798_ChIP-Seq_JUKART_Human2.93336955
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.73468318
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.69211573
12MYC_22102868_ChIP-Seq_BL_Human2.65135986
13MAF_26560356_Chip-Seq_TH1_Human2.62160208
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59116373
15VDR_24763502_ChIP-Seq_THP-1_Human2.58560514
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.48542875
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.46473522
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.41034589
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.40446120
20MYB_26560356_Chip-Seq_TH2_Human2.38127689
21TCF7_22412390_ChIP-Seq_EML_Mouse2.31859600
22EGR1_19374776_ChIP-ChIP_THP-1_Human2.28637059
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.27110663
24UTX_26944678_Chip-Seq_JUKART_Human2.24534349
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.23785050
26E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.23575285
27RUNX1_22412390_ChIP-Seq_EML_Mouse2.23427242
28STAT6_21828071_ChIP-Seq_BEAS2B_Human2.22061098
29BRD4_27068464_Chip-Seq_AML-cells_Mouse2.18571051
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.18454849
31SCL_19346495_ChIP-Seq_HPC-7_Human2.15742542
32SPI1_23127762_ChIP-Seq_K562_Human2.14098263
33SPI1_23547873_ChIP-Seq_NB4_Human2.13979495
34KDM2B_26808549_Chip-Seq_DND41_Human2.12632821
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.10371096
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.06725100
37STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.05283323
38MYB_26560356_Chip-Seq_TH1_Human2.04847453
39KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.04585203
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.03673805
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00094158
42MAF_26560356_Chip-Seq_TH2_Human1.97815323
43KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.90039890
44RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.81142882
45GATA3_27048872_Chip-Seq_THYMUS_Human1.64989372
46MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64249976
47GATA1_19941827_ChIP-Seq_MEL_Mouse1.56532149
48TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50651350
49KDM2B_26808549_Chip-Seq_JURKAT_Human1.48244224
50VDR_24787735_ChIP-Seq_THP-1_Human1.48243658
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46553248
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43345909
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.40859296
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37965533
55PU_27001747_Chip-Seq_BMDM_Mouse1.35679409
56LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.33849017
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31705598
58GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30862165
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.26545078
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25130684
61LXR_22292898_ChIP-Seq_THP-1_Human1.25126495
62GATA1_19941826_ChIP-Seq_K562_Human1.24769379
63PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23492987
64PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19612050
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14853690
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14081660
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.13117811
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.08488047
69PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05425687
70GATA3_26560356_Chip-Seq_TH2_Human1.05014320
71CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04548554
72GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04137922
73CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03633900
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03311911
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01537006
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01067729
77VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00275593
78SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99912505
79NCOR1_26117541_ChIP-Seq_K562_Human0.98182442
80CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98014342
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97701396
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96763827
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96733912
84ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95382409
85SA1_27219007_Chip-Seq_ERYTHROID_Human0.94369100
86NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91849962
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88882548
88GATA1_22025678_ChIP-Seq_K562_Human0.88655505
89PPARA_22158963_ChIP-Seq_LIVER_Mouse0.88019267
90GATA2_19941826_ChIP-Seq_K562_Human0.87887742
91RACK7_27058665_Chip-Seq_MCF-7_Human0.87819553
92ELF1_20517297_ChIP-Seq_JURKAT_Human0.87436245
93KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.86996447
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86542939
95TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84400851
96KDM2B_26808549_Chip-Seq_K562_Human0.83864629
97CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.83289489
98BCOR_27268052_Chip-Seq_Bcells_Human0.82999790
99BCL6_27268052_Chip-Seq_Bcells_Human0.81461480
100RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80834028

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to3.90181990
2MP0003303_peritoneal_inflammation3.72912816
3MP0003724_increased_susceptibility_to3.70096685
4MP0001835_abnormal_antigen_presentation3.29749839
5MP0005451_abnormal_body_composition2.92464183
6MP0001800_abnormal_humoral_immune2.80775150
7MP0003763_abnormal_thymus_physiology2.77547926
8MP0005671_abnormal_response_to2.69743334
9MP0001790_abnormal_immune_system2.69044301
10MP0005387_immune_system_phenotype2.69044301
11MP0002419_abnormal_innate_immunity2.68871594
12MP0005000_abnormal_immune_tolerance2.66143221
13MP0005025_abnormal_response_to2.61718463
14MP0009785_altered_susceptibility_to2.61661007
15MP0002723_abnormal_immune_serum2.46631236
16MP0002452_abnormal_antigen_presenting2.35925650
17MP0002420_abnormal_adaptive_immunity2.32468441
18MP0000685_abnormal_immune_system2.32235070
19MP0001819_abnormal_immune_cell2.30265455
20MP0002148_abnormal_hypersensitivity_rea2.25150633
21MP0006082_CNS_inflammation2.21280307
22MP0002138_abnormal_hepatobiliary_system2.13308441
23MP0002132_abnormal_respiratory_system2.09424429
24MP0003300_gastrointestinal_ulcer2.03045155
25MP0005464_abnormal_platelet_physiology1.98687925
26MP0009278_abnormal_bone_marrow1.95428954
27MP0002398_abnormal_bone_marrow1.95338152
28MP0002405_respiratory_system_inflammati1.94870097
29MP0009333_abnormal_splenocyte_physiolog1.91593871
30MP0001533_abnormal_skeleton_physiology1.84809771
31MP0000716_abnormal_immune_system1.84550010
32MP0010155_abnormal_intestine_physiology1.82262671
33MP0004510_myositis1.78537423
34MP0003828_pulmonary_edema1.78164254
35MP0003191_abnormal_cellular_cholesterol1.77462664
36MP0008260_abnormal_autophagy1.76408383
37MP0004947_skin_inflammation1.75507032
38MP0000689_abnormal_spleen_morphology1.58363680
39MP0001845_abnormal_inflammatory_respons1.57754573
40MP0003172_abnormal_lysosome_physiology1.55557497
41MP0000703_abnormal_thymus_morphology1.54063656
42MP0002722_abnormal_immune_system1.52623047
43MP0001851_eye_inflammation1.52313617
44MP0002332_abnormal_exercise_endurance1.46600421
45MP0002277_abnormal_respiratory_mucosa1.45610190
46MP0005058_abnormal_lysosome_morphology1.45392106
47MP0002429_abnormal_blood_cell1.44377876
48MP0008469_abnormal_protein_level1.40233057
49MP0004130_abnormal_muscle_cell1.40106815
50MP0002396_abnormal_hematopoietic_system1.39965200
51MP0000465_gastrointestinal_hemorrhage1.39666366
52MP0002998_abnormal_bone_remodeling1.37048568
53MP0001545_abnormal_hematopoietic_system1.35997669
54MP0005397_hematopoietic_system_phenotyp1.35997669
55MP0004883_abnormal_blood_vessel1.35035707
56MP0003656_abnormal_erythrocyte_physiolo1.34519564
57MP0001853_heart_inflammation1.32784510
58MP0009764_decreased_sensitivity_to1.27957816
59MP0004808_abnormal_hematopoietic_stem1.25050272
60MP0004145_abnormal_muscle_electrophysio1.24748036
61MP0003646_muscle_fatigue1.21208297
62MP0000858_altered_metastatic_potential1.14928743
63MP0003075_altered_response_to1.14867280
64MP0001873_stomach_inflammation1.14080952
65MP0005310_abnormal_salivary_gland1.10878564
66MP0004381_abnormal_hair_follicle1.10116306
67MP0003866_abnormal_defecation1.08355963
68MP0005166_decreased_susceptibility_to1.07278738
69MP0005164_abnormal_response_to1.03893947
70MP0004185_abnormal_adipocyte_glucose1.03340432
71MP0009763_increased_sensitivity_to1.01833678
72MP0008004_abnormal_stomach_pH1.01754102
73MP0002009_preneoplasia0.91348770
74MP0002933_joint_inflammation0.90421552
75MP0005666_abnormal_adipose_tissue0.89779982
76MP0003448_altered_tumor_morphology0.87548068
77MP0003806_abnormal_nucleotide_metabolis0.85401825
78MP0005076_abnormal_cell_differentiation0.85202371
79MP0004036_abnormal_muscle_relaxation0.85014226
80MP0003690_abnormal_glial_cell0.83144811
81MP0000249_abnormal_blood_vessel0.82143391
82MP0003091_abnormal_cell_migration0.82141415
83MP0009765_abnormal_xenobiotic_induced0.81523271
84MP0000343_altered_response_to0.80500229
85MP0002106_abnormal_muscle_physiology0.79748110
86MP0004087_abnormal_muscle_fiber0.77228754
87MP0000490_abnormal_crypts_of0.76397304
88MP0001663_abnormal_digestive_system0.75890501
89MP0000747_muscle_weakness0.74990064
90MP0000749_muscle_degeneration0.74623145
91MP0002166_altered_tumor_susceptibility0.74501402
92MP0003221_abnormal_cardiomyocyte_apopto0.74003229
93MP0000751_myopathy0.72836427
94MP0005390_skeleton_phenotype0.68830594
95MP0003453_abnormal_keratinocyte_physiol0.67431519
96MP0003045_fibrosis0.65718134
97MP0000759_abnormal_skeletal_muscle0.65459442
98MP0008961_abnormal_basal_metabolism0.64853221
99MP0005266_abnormal_metabolism0.63754577
100MP0008874_decreased_physiological_sensi0.63726834

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.19909366
2Recurrent bacterial skin infections (HP:0005406)4.78433525
3Recurrent abscess formation (HP:0002722)4.68944866
4Myositis (HP:0100614)4.45895816
5Stomatitis (HP:0010280)4.33683154
6Recurrent gram-negative bacterial infections (HP:0005420)4.11267499
7Muscle fiber inclusion bodies (HP:0100299)3.92743264
8Abnormality of macrophages (HP:0004311)3.91194595
9Nemaline bodies (HP:0003798)3.86855740
10Retrobulbar optic neuritis (HP:0100654)3.81058440
11Optic neuritis (HP:0100653)3.81058440
12Orchitis (HP:0100796)3.79705827
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.79475464
14Nasal polyposis (HP:0100582)3.73874517
15Exercise-induced myalgia (HP:0003738)3.73220257
16Elevated erythrocyte sedimentation rate (HP:0003565)3.69636278
17Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.67556401
18Absent/shortened dynein arms (HP:0200106)3.54179713
19Dynein arm defect of respiratory motile cilia (HP:0012255)3.54179713
20Mediastinal lymphadenopathy (HP:0100721)3.49882821
21Recurrent fungal infections (HP:0002841)3.41842415
22Meningitis (HP:0001287)3.41759937
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.25097592
24Prolonged bleeding time (HP:0003010)3.23445352
25Abnormal respiratory epithelium morphology (HP:0012253)3.22157458
26Abnormal respiratory motile cilium morphology (HP:0005938)3.22157458
27Abnormality of the nasal mucosa (HP:0000433)3.15730779
28Abnormal respiratory motile cilium physiology (HP:0012261)3.14730068
29Panhypogammaglobulinemia (HP:0003139)3.13511243
30Spontaneous hematomas (HP:0007420)3.10212192
31Abnormal ciliary motility (HP:0012262)3.09959622
32Recurrent skin infections (HP:0001581)3.07700705
33Increased IgE level (HP:0003212)3.04380057
34Obstructive lung disease (HP:0006536)3.03129860
35Chronic obstructive pulmonary disease (HP:0006510)3.03129860
36Recurrent viral infections (HP:0004429)3.01432083
37Muscle fiber splitting (HP:0003555)3.00793122
38T lymphocytopenia (HP:0005403)2.96389164
39Encephalitis (HP:0002383)2.94475192
40Recurrent sinusitis (HP:0011108)2.93178182
41Gastrointestinal infarctions (HP:0005244)2.82589292
42Keratoconjunctivitis sicca (HP:0001097)2.82333744
43Vasculitis (HP:0002633)2.81811328
44Bronchiectasis (HP:0002110)2.75664624
45Difficulty running (HP:0009046)2.75659158
46Chronic otitis media (HP:0000389)2.75521998
47Rhinitis (HP:0012384)2.69790614
48Chronic mucocutaneous candidiasis (HP:0002728)2.69127144
49Recurrent cutaneous fungal infections (HP:0011370)2.69127144
50Abnormality of T cell number (HP:0011839)2.66799734
51Epistaxis (HP:0000421)2.58442652
52Gingivitis (HP:0000230)2.58323992
53Chest pain (HP:0100749)2.53841951
54Recurrent bronchitis (HP:0002837)2.52715870
55Cellulitis (HP:0100658)2.49975240
56Pustule (HP:0200039)2.49349724
57Inflammation of the large intestine (HP:0002037)2.48595010
58Purpura (HP:0000979)2.47626389
59Gastrointestinal inflammation (HP:0004386)2.45474556
60Centrally nucleated skeletal muscle fibers (HP:0003687)2.44615746
61Recurrent otitis media (HP:0000403)2.42988504
62Keratoconjunctivitis (HP:0001096)2.42805764
63Bronchitis (HP:0012387)2.41120743
64Granulocytopenia (HP:0001913)2.36835212
65Arterial thrombosis (HP:0004420)2.34515327
66Gingival bleeding (HP:0000225)2.31641711
67Ulnar deviation of the wrist (HP:0003049)2.31307494
68Leukocytosis (HP:0001974)2.30037518
69Myopathic facies (HP:0002058)2.29375268
70Type 1 muscle fiber predominance (HP:0003803)2.26767707
71Agammaglobulinemia (HP:0004432)2.24740330
72Abnormality of T cells (HP:0002843)2.24647048
73Chronic bronchitis (HP:0004469)2.24255102
74Colitis (HP:0002583)2.23462697
75Papilledema (HP:0001085)2.22764111
76Increased serum ferritin (HP:0003281)2.22692308
77Pulmonary infiltrates (HP:0002113)2.18254698
78Urticaria (HP:0001025)2.17232517
79Abnormality of skeletal muscle fiber size (HP:0012084)2.13806266
80Hemoptysis (HP:0002105)2.12295433
81Pulmonary embolism (HP:0002204)2.11607105
82Chronic sinusitis (HP:0011109)2.10315530
83Episodic fever (HP:0001954)2.07528034
84Obstructive sleep apnea (HP:0002870)2.07455247
85EMG: myopathic abnormalities (HP:0003458)2.06929769
86Hypochromic anemia (HP:0001931)2.04624670
87IgM deficiency (HP:0002850)2.03989706
88Abnormality of the fingertips (HP:0001211)2.02612869
89Distal lower limb muscle weakness (HP:0009053)2.02185017
90Abnormality of the left ventricular outflow tract (HP:0011103)2.00674673
91Subaortic stenosis (HP:0001682)2.00674673
92Eosinophilia (HP:0001880)1.99647266
93Segmental peripheral demyelination/remyelination (HP:0003481)1.99108885
94Asymmetric septal hypertrophy (HP:0001670)1.98520556
95Anorexia (HP:0002039)1.98315634
96Hypochromic microcytic anemia (HP:0004840)1.98089836
97Autoimmune hemolytic anemia (HP:0001890)1.97257107
98Lymphopenia (HP:0001888)1.97081649
99Gangrene (HP:0100758)1.96323731
100Exercise-induced muscle cramps (HP:0003710)1.92023501

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.06312267
2MAP4K13.51565177
3PRPF4B3.18045974
4MAP2K32.82700491
5BLK2.82220082
6TYK22.66647585
7IRAK42.61929502
8ZAP702.29728500
9CSK2.23517780
10OBSCN2.21695521
11MAPK152.09520725
12TXK2.03534193
13TNK22.03440581
14MAP3K141.96077321
15IKBKE1.90106958
16TBK11.86162998
17ERN11.84916114
18FES1.78432339
19TAOK11.76295809
20MAP3K131.72279161
21BTK1.70955804
22TTN1.67336285
23MAP3K31.59470893
24GRK61.58043321
25JAK31.54266696
26SYK1.45921098
27HCK1.44988753
28EPHB11.41614911
29TRIB31.39115725
30MAPK121.34432520
31JAK11.32176829
32MAP3K71.25626781
33MAP3K101.25250349
34TEC1.23959397
35MARK21.22981260
36ITK1.19690195
37SMG11.19662068
38LCK1.19521825
39CDC42BPA1.14989971
40IRAK11.13498378
41SIK31.12371507
42LYN1.08371919
43FGR1.08319160
44CDK121.07290194
45JAK21.03531579
46MAP3K11.03047684
47PIK3CG1.02464166
48TAOK31.00041135
49MARK30.96540173
50KIT0.95369121
51TAOK20.93972553
52IRAK20.93901265
53STK100.93019338
54HIPK20.91910809
55SIK20.91609312
56MAPK70.91390101
57NLK0.90629663
58CSF1R0.88064593
59IKBKB0.86587280
60MAP3K110.84968761
61MAP3K60.81810495
62PRKCQ0.80358566
63PDK10.73448146
64SIK10.72691629
65FGFR40.69251653
66FGFR30.69148170
67CDK190.68938782
68MATK0.66416112
69TGFBR20.64595819
70YES10.64436995
71KSR20.64244341
72BMPR20.61943968
73PRKD20.61411047
74DYRK1B0.57769818
75PDPK10.55689555
76SGK30.54213669
77CDK40.53906481
78CDK60.53251203
79CDK90.53170909
80SGK20.51715085
81RPS6KC10.50187373
82RPS6KL10.50187373
83STK240.49399997
84MELK0.42788598
85MAP3K50.42778240
86MAPK40.41657683
87STK110.41186075
88CAMK40.41046817
89STK380.41023375
90CHUK0.40878624
91FYN0.40505688
92MOS0.40396387
93BMPR1B0.39837527
94CDK80.39777179
95PIM10.38074523
96PTK60.36872914
97MAP2K40.36676982
98GRK70.36672190
99DYRK30.36432789
100MAP2K60.36276996

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.95116355
2Leishmaniasis_Homo sapiens_hsa051402.68603683
3B cell receptor signaling pathway_Homo sapiens_hsa046622.54969693
4Staphylococcus aureus infection_Homo sapiens_hsa051502.44065904
5Primary immunodeficiency_Homo sapiens_hsa053402.38899086
6Allograft rejection_Homo sapiens_hsa053302.21015612
7Graft-versus-host disease_Homo sapiens_hsa053322.16732666
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.12709268
9T cell receptor signaling pathway_Homo sapiens_hsa046602.08998592
10Autoimmune thyroid disease_Homo sapiens_hsa053202.03545471
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.97920193
12Acute myeloid leukemia_Homo sapiens_hsa052211.97217748
13NOD-like receptor signaling pathway_Homo sapiens_hsa046211.90821859
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.89573098
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.88837027
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.88574968
17Hematopoietic cell lineage_Homo sapiens_hsa046401.83719102
18Tuberculosis_Homo sapiens_hsa051521.83490765
19Measles_Homo sapiens_hsa051621.80363150
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.65928392
21Other glycan degradation_Homo sapiens_hsa005111.65269432
22Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.63682065
23Influenza A_Homo sapiens_hsa051641.59125714
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.55660139
25Malaria_Homo sapiens_hsa051441.55423283
26Viral myocarditis_Homo sapiens_hsa054161.48978754
27Herpes simplex infection_Homo sapiens_hsa051681.46198231
28Toxoplasmosis_Homo sapiens_hsa051451.44631106
29TNF signaling pathway_Homo sapiens_hsa046681.43323829
30Chemokine signaling pathway_Homo sapiens_hsa040621.39047942
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.37907777
32Type I diabetes mellitus_Homo sapiens_hsa049401.34342765
33Asthma_Homo sapiens_hsa053101.32002714
34Antigen processing and presentation_Homo sapiens_hsa046121.28308787
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27768184
36Non-small cell lung cancer_Homo sapiens_hsa052231.19640820
37Hepatitis C_Homo sapiens_hsa051601.19080032
38Legionellosis_Homo sapiens_hsa051341.18818917
39Dorso-ventral axis formation_Homo sapiens_hsa043201.18213517
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.17535460
41Pertussis_Homo sapiens_hsa051331.17410315
42Hepatitis B_Homo sapiens_hsa051611.17199642
43Platelet activation_Homo sapiens_hsa046111.15059483
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14001983
45Chronic myeloid leukemia_Homo sapiens_hsa052201.09463321
46VEGF signaling pathway_Homo sapiens_hsa043701.08510407
47African trypanosomiasis_Homo sapiens_hsa051431.05800223
48Pancreatic cancer_Homo sapiens_hsa052121.03509963
49Prolactin signaling pathway_Homo sapiens_hsa049171.00984374
50Renal cell carcinoma_Homo sapiens_hsa052110.94939474
51Rheumatoid arthritis_Homo sapiens_hsa053230.94212674
52Notch signaling pathway_Homo sapiens_hsa043300.93796208
53Neurotrophin signaling pathway_Homo sapiens_hsa047220.93319053
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.89357123
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88749918
56Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.87937618
57Epstein-Barr virus infection_Homo sapiens_hsa051690.84850889
58Insulin resistance_Homo sapiens_hsa049310.83285888
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82583878
60FoxO signaling pathway_Homo sapiens_hsa040680.79165138
61Apoptosis_Homo sapiens_hsa042100.77494184
62Amoebiasis_Homo sapiens_hsa051460.77158748
63Colorectal cancer_Homo sapiens_hsa052100.76478830
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.76098551
65HTLV-I infection_Homo sapiens_hsa051660.75878418
66Phagosome_Homo sapiens_hsa041450.74504726
67Insulin signaling pathway_Homo sapiens_hsa049100.74204851
68Choline metabolism in cancer_Homo sapiens_hsa052310.73997497
69Salmonella infection_Homo sapiens_hsa051320.73887393
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.73827101
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73250495
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.68791096
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.66817092
74GnRH signaling pathway_Homo sapiens_hsa049120.65551485
75Endometrial cancer_Homo sapiens_hsa052130.64195738
76Type II diabetes mellitus_Homo sapiens_hsa049300.62919597
77Complement and coagulation cascades_Homo sapiens_hsa046100.62091465
78MAPK signaling pathway_Homo sapiens_hsa040100.61571988
79mTOR signaling pathway_Homo sapiens_hsa041500.61289704
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60940888
81Viral carcinogenesis_Homo sapiens_hsa052030.59712049
82Shigellosis_Homo sapiens_hsa051310.58052464
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.56773029
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55875746
85Lysosome_Homo sapiens_hsa041420.54615570
86Prostate cancer_Homo sapiens_hsa052150.53322075
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52153535
88Endocytosis_Homo sapiens_hsa041440.50112915
89Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49963321
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49380208
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.47437443
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46233064
93Long-term potentiation_Homo sapiens_hsa047200.45964111
94ErbB signaling pathway_Homo sapiens_hsa040120.45141657
95Inositol phosphate metabolism_Homo sapiens_hsa005620.43662508
96Regulation of autophagy_Homo sapiens_hsa041400.41277217
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36546328
98HIF-1 signaling pathway_Homo sapiens_hsa040660.35426156
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32271988
100Prion diseases_Homo sapiens_hsa050200.32245220

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