TMEM115

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.49300108
2COPI coating of Golgi vesicle (GO:0048205)4.49300108
3lysine catabolic process (GO:0006554)4.37724428
4lysine metabolic process (GO:0006553)4.37724428
5sulfur amino acid catabolic process (GO:0000098)4.15742788
6protein localization to endosome (GO:0036010)4.04625864
7alpha-linolenic acid metabolic process (GO:0036109)3.83739460
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.77709987
9L-phenylalanine metabolic process (GO:0006558)3.77709987
10cysteine metabolic process (GO:0006534)3.68592840
11virion attachment to host cell (GO:0019062)3.65265401
12adhesion of symbiont to host cell (GO:0044650)3.65265401
13positive regulation of receptor recycling (GO:0001921)3.62561320
14positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)3.61012918
15adhesion of symbiont to host (GO:0044406)3.59442367
16pentose-phosphate shunt (GO:0006098)3.58957274
17protein maturation by protein folding (GO:0022417)3.58808969
18negative regulation of fibrinolysis (GO:0051918)3.55478280
19regulation of cholesterol homeostasis (GO:2000188)3.47749928
20skin morphogenesis (GO:0043589)3.44823342
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.37590042
22L-phenylalanine catabolic process (GO:0006559)3.37590042
23purine nucleotide salvage (GO:0032261)3.36741360
24triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.35066701
25NADPH regeneration (GO:0006740)3.28203438
26maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26948403
27positive regulation of triglyceride biosynthetic process (GO:0010867)3.26931826
284-hydroxyproline metabolic process (GO:0019471)3.26860049
29aspartate family amino acid catabolic process (GO:0009068)3.26656475
30glycosphingolipid catabolic process (GO:0046479)3.25669188
31glyoxylate metabolic process (GO:0046487)3.25145230
32amyloid precursor protein catabolic process (GO:0042987)3.22876753
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.16473697
34protein retention in ER lumen (GO:0006621)3.16464306
35serine family amino acid biosynthetic process (GO:0009070)3.16217844
36endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.15579632
37homocysteine metabolic process (GO:0050667)3.13428590
38low-density lipoprotein particle clearance (GO:0034383)3.07405958
39positive regulation of triglyceride metabolic process (GO:0090208)3.07193518
40regulation of cholesterol storage (GO:0010885)3.05736115
41regulation of early endosome to late endosome transport (GO:2000641)3.05200843
42positive regulation of chemokine biosynthetic process (GO:0045080)3.03403577
43stress fiber assembly (GO:0043149)3.02465724
44pinocytosis (GO:0006907)3.02412126
45extracellular fibril organization (GO:0043206)3.01216776
46fibril organization (GO:0097435)2.98928188
47cellular modified amino acid catabolic process (GO:0042219)2.98410924
48amino sugar catabolic process (GO:0046348)2.97548132
49positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97174395
50nucleotide salvage (GO:0043173)2.95881144
51response to mercury ion (GO:0046689)2.91566246
52negative regulation of cell size (GO:0045792)2.90538793
53glycolipid catabolic process (GO:0019377)2.90467629
54regulation of cholesterol metabolic process (GO:0090181)2.90464298
55hyaluronan catabolic process (GO:0030214)2.89512900
56negative regulation of nitric oxide biosynthetic process (GO:0045019)2.86964160
57positive regulation of natural killer cell differentiation (GO:0032825)2.86858667
58embryo implantation (GO:0007566)2.86794042
59antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.86146271
60antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.86146271
61negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.85420374
62plasma lipoprotein particle clearance (GO:0034381)2.82844500
63regulation of protein activation cascade (GO:2000257)2.82403578
64maternal placenta development (GO:0001893)2.82328208
65folic acid-containing compound biosynthetic process (GO:0009396)2.81934493
66regulation of mammary gland epithelial cell proliferation (GO:0033599)2.80364952
67positive regulation of lipoprotein lipase activity (GO:0051006)2.77875975
68positive regulation of triglyceride lipase activity (GO:0061365)2.77875975
69glycine metabolic process (GO:0006544)2.77387601
70cellular ketone body metabolic process (GO:0046950)2.77065630
71apoptotic cell clearance (GO:0043277)2.76795194
72regulation of complement activation (GO:0030449)2.75977599
73regulation of fatty acid beta-oxidation (GO:0031998)2.75550128
74folic acid metabolic process (GO:0046655)2.74470278
75activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74406190
76negative regulation of erythrocyte differentiation (GO:0045647)2.74264778
77modulation by symbiont of host cellular process (GO:0044068)2.74038489
78L-serine metabolic process (GO:0006563)2.73258024
792-oxoglutarate metabolic process (GO:0006103)2.72149438
80amino-acid betaine metabolic process (GO:0006577)2.71736033
81GDP-mannose metabolic process (GO:0019673)2.71613176
82regulation of triglyceride catabolic process (GO:0010896)2.70577602
83valine metabolic process (GO:0006573)2.69807217
84serine family amino acid metabolic process (GO:0009069)2.69761125
85DNA deamination (GO:0045006)2.69646106
86positive regulation of nuclease activity (GO:0032075)2.69248717
87bile acid biosynthetic process (GO:0006699)2.68678151
88regulation of vitamin D biosynthetic process (GO:0060556)2.67689310
89aromatic amino acid family catabolic process (GO:0009074)2.67473427
90cellular response to arsenic-containing substance (GO:0071243)2.66583553
91regulation of fibrinolysis (GO:0051917)2.65787295
92high-density lipoprotein particle remodeling (GO:0034375)2.65242542
93UV protection (GO:0009650)2.65146514
94serine transport (GO:0032329)2.64638320
95regulation of cholesterol biosynthetic process (GO:0045540)2.63916556
96reverse cholesterol transport (GO:0043691)2.63606906
97protein carboxylation (GO:0018214)2.63269634
98peptidyl-glutamic acid carboxylation (GO:0017187)2.63269634
99decidualization (GO:0046697)2.63247469
100tricarboxylic acid metabolic process (GO:0072350)2.62912814
101heme transport (GO:0015886)2.61567808
102glial cell migration (GO:0008347)2.61189377
103negative regulation of cholesterol transport (GO:0032375)2.60740617
104negative regulation of sterol transport (GO:0032372)2.60740617
105galactose catabolic process (GO:0019388)2.59592587
106regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58881187
107positive regulation of fatty acid biosynthetic process (GO:0045723)2.58734619
108kynurenine metabolic process (GO:0070189)2.58527535
109barbed-end actin filament capping (GO:0051016)2.57808963
110peptidyl-proline hydroxylation (GO:0019511)2.57258009
111cellular copper ion homeostasis (GO:0006878)2.56884758
112complement activation, alternative pathway (GO:0006957)2.56568796
113type B pancreatic cell proliferation (GO:0044342)2.55879567
114protein insertion into membrane (GO:0051205)2.55569388
115AMP metabolic process (GO:0046033)2.55341135
116drug transport (GO:0015893)2.54570295
117regulation of chemokine biosynthetic process (GO:0045073)2.54254832
118regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.52650330
119response to thyroid hormone (GO:0097066)2.50997640
120regulation of extracellular matrix disassembly (GO:0010715)2.50502452
121NIK/NF-kappaB signaling (GO:0038061)2.49824969
122lipopolysaccharide biosynthetic process (GO:0009103)2.49455151
123cell migration involved in heart development (GO:0060973)2.48384330
124fatty acid beta-oxidation (GO:0006635)2.47955827
125endodermal cell differentiation (GO:0035987)2.47701146
126regulation of plasminogen activation (GO:0010755)2.47613143
127vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.46055461
128negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45796468
129positive regulation of pseudopodium assembly (GO:0031274)2.45598644
130endoplasmic reticulum unfolded protein response (GO:0030968)2.44907042
131basement membrane organization (GO:0071711)2.44833291
132acute-phase response (GO:0006953)2.44549751
133protein-lipid complex assembly (GO:0065005)2.44546175
134regulation of cholesterol esterification (GO:0010872)2.44160432
135tooth mineralization (GO:0034505)2.44138959
136ethanol oxidation (GO:0006069)2.43865173
137fatty acid oxidation (GO:0019395)2.42814876
138cell adhesion mediated by integrin (GO:0033627)2.40421988
139positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.39693068
140regulation of nuclease activity (GO:0032069)2.39671874
141ketone body metabolic process (GO:1902224)2.38973711
142retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.38837997
143regulation of membrane protein ectodomain proteolysis (GO:0051043)2.38542723
144phospholipid efflux (GO:0033700)2.38245489
145folic acid transport (GO:0015884)2.38221528
146oxaloacetate metabolic process (GO:0006107)2.38151726
147protein autoprocessing (GO:0016540)2.38060033
148lipid oxidation (GO:0034440)2.37955430
149plasma lipoprotein particle assembly (GO:0034377)2.37173406
150acetyl-CoA metabolic process (GO:0006084)2.36938098
151proline biosynthetic process (GO:0006561)2.36646491
152urea metabolic process (GO:0019627)2.36337256
153urea cycle (GO:0000050)2.36337256
154response to laminar fluid shear stress (GO:0034616)2.35892282
155sphingolipid catabolic process (GO:0030149)2.35697650
156cellular response to thyroid hormone stimulus (GO:0097067)2.34805966
157regulation of vitamin metabolic process (GO:0030656)2.34710669
158regulation of receptor recycling (GO:0001919)2.33945764
159mannose metabolic process (GO:0006013)2.32936182
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.32842043
161substrate-dependent cell migration (GO:0006929)2.32269300
162ceramide catabolic process (GO:0046514)2.32168509
163glucose catabolic process (GO:0006007)2.31697013
164adherens junction assembly (GO:0034333)2.31079105
165lipopolysaccharide metabolic process (GO:0008653)2.30178087
166modulation by virus of host process (GO:0019054)2.29687966
167membrane lipid catabolic process (GO:0046466)2.28333172
168mitotic nuclear envelope reassembly (GO:0007084)2.27444484
169nuclear envelope reassembly (GO:0031468)2.27444484
170regulation of superoxide anion generation (GO:0032928)2.26346739
171positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.24796518
172response to peptidoglycan (GO:0032494)2.24122603
173L-serine transport (GO:0015825)2.23308880

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.77254789
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89631207
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.17838148
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.15690387
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.07381948
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.68242459
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.37464172
8LXR_22158963_ChIP-Seq_LIVER_Mouse2.21979719
9CLOCK_20551151_ChIP-Seq_293T_Human2.10035941
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09688537
11NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.01410606
12LXR_22292898_ChIP-Seq_THP-1_Human1.99992161
13* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.97738399
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.88406977
15MYC_22102868_ChIP-Seq_BL_Human1.83573420
16FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.83329694
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82675747
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73703845
19TRIM28_21343339_ChIP-Seq_HEK293_Human1.64140382
20TP63_17297297_ChIP-ChIP_HaCaT_Human1.63079197
21VDR_21846776_ChIP-Seq_THP-1_Human1.61099362
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60793064
23EGR1_23403033_ChIP-Seq_LIVER_Mouse1.60269256
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57715151
25RACK7_27058665_Chip-Seq_MCF-7_Human1.53812242
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.48765548
27CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47169185
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44136920
29ATF3_27146783_Chip-Seq_COLON_Human1.42101643
30TP53_22127205_ChIP-Seq_IMR90_Human1.41832764
31TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.41756049
32STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37525443
33KDM2B_26808549_Chip-Seq_K562_Human1.35069997
34ZNF263_19887448_ChIP-Seq_K562_Human1.34869237
35MYC_18555785_ChIP-Seq_MESCs_Mouse1.33046062
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.31475072
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30925032
38CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.30216150
39MYC_18358816_ChIP-ChIP_MESCs_Mouse1.27806623
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26505507
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26205555
42* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26187210
43* VDR_24763502_ChIP-Seq_THP-1_Human1.24777369
44ELF1_20517297_ChIP-Seq_JURKAT_Human1.24399461
45SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24340520
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24206879
47SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24094316
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.22373803
49BCOR_27268052_Chip-Seq_Bcells_Human1.21538794
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.21421376
51BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21014134
52BCL6_27268052_Chip-Seq_Bcells_Human1.20983329
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.20835972
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19970691
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19041695
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.18739977
57MAF_26560356_Chip-Seq_TH1_Human1.18575548
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.18507241
59SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18454697
60KDM2B_26808549_Chip-Seq_DND41_Human1.17994402
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17742973
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17731683
63GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16471132
64KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16110677
65* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16003728
66RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.15699397
67TET1_21451524_ChIP-Seq_MESCs_Mouse1.14719147
68* SMC4_20622854_ChIP-Seq_HELA_Human1.14393959
69ERG_21242973_ChIP-ChIP_JURKAT_Human1.14060335
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13804096
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13267406
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.12992831
73EGR1_19374776_ChIP-ChIP_THP-1_Human1.12092145
74CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.11937138
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11857861
76P68_20966046_ChIP-Seq_HELA_Human1.11510796
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.10721072
78NCOR1_26117541_ChIP-Seq_K562_Human1.10368247
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.10304368
80TFEB_21752829_ChIP-Seq_HELA_Human1.10042239
81* TCF7_22412390_ChIP-Seq_EML_Mouse1.09384611
82STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09094915
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09043687
84* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08959494
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.08003536
86RUNX1_22412390_ChIP-Seq_EML_Mouse1.07862327
87XRN2_22483619_ChIP-Seq_HELA_Human1.07222929
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.06984920
89ESR2_21235772_ChIP-Seq_MCF-7_Human1.06219482
90* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05672461
91* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.05127992
92GATA1_22025678_ChIP-Seq_K562_Human1.05022116
93ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.04584672
94HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04576100
95* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04343451
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04309918
97* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.03676865
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.03380153
99* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03291382
100* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03028569
101MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03022442
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02328839
103CREB1_26743006_Chip-Seq_LNCaP_Human1.01950426
104CTCF_26484167_Chip-Seq_Bcells_Mouse1.01855170
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01652178
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01561005
107JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.00520481
108UTX_26944678_Chip-Seq_JUKART_Human1.00157189
109TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99949451
110NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98794860
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98704791
112* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98067191
113SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98065129
114* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98044314
115NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97390368
116YY1_22570637_ChIP-Seq_MALME-3M_Human0.97199771
117P300_27058665_Chip-Seq_ZR-75-30cells_Human0.96599053
118* MAF_26560356_Chip-Seq_TH2_Human0.96524515
119SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96359725
120TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96355581
121MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96244124
122CTCF_21964334_Chip-Seq_Bcells_Human0.95296639
123PHF8_20622854_ChIP-Seq_HELA_Human0.95001632
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94367119
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93811491
126P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92847037
127KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92680860
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92654470
129KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91504993
130GABP_19822575_ChIP-Seq_HepG2_Human0.91371825
131GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91348326

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009840_abnormal_foam_cell3.83841614
2MP0002139_abnormal_hepatobiliary_system3.81951021
3MP0005360_urolithiasis3.57214238
4MP0003705_abnormal_hypodermis_morpholog3.42615605
5MP0003806_abnormal_nucleotide_metabolis3.29695617
6MP0003191_abnormal_cellular_cholesterol3.07521869
7MP0005365_abnormal_bile_salt2.97075029
8MP0005451_abnormal_body_composition2.86899250
9MP0008438_abnormal_cutaneous_collagen2.72337616
10MP0005085_abnormal_gallbladder_physiolo2.44443624
11MP0008260_abnormal_autophagy2.39156031
12MP0005083_abnormal_biliary_tract2.25210227
13MP0005058_abnormal_lysosome_morphology2.22817327
14MP0003252_abnormal_bile_duct2.02041841
15MP0004510_myositis2.01711783
16MP0008875_abnormal_xenobiotic_pharmacok1.96762172
17MP0006054_spinal_hemorrhage1.87278056
18MP0010329_abnormal_lipoprotein_level1.85944096
19MP0001542_abnormal_bone_strength1.85476909
20MP0003279_aneurysm1.83193224
21MP0001666_abnormal_nutrient_absorption1.72371590
22MP0005332_abnormal_amino_acid1.71318509
23MP0002877_abnormal_melanocyte_morpholog1.67728279
24MP0003283_abnormal_digestive_organ1.67525921
25MP0003186_abnormal_redox_activity1.61689750
26MP0003724_increased_susceptibility_to1.58002700
27MP0003453_abnormal_keratinocyte_physiol1.54403231
28MP0005319_abnormal_enzyme/_coenzyme1.52108515
29MP0005623_abnormal_meninges_morphology1.52085421
30MP0003566_abnormal_cell_adhesion1.49222656
31MP0000609_abnormal_liver_physiology1.48233949
32MP0005023_abnormal_wound_healing1.46473309
33MP0003300_gastrointestinal_ulcer1.46232208
34MP0010352_gastrointestinal_tract_polyps1.45581200
35MP0010368_abnormal_lymphatic_system1.43345698
36MP0009643_abnormal_urine_homeostasis1.42419937
37MP0003195_calcinosis1.38072442
38MP0003436_decreased_susceptibility_to1.37139705
39MP0000604_amyloidosis1.36269075
40MP0000750_abnormal_muscle_regeneration1.33786072
41MP0000751_myopathy1.33727928
42MP0002138_abnormal_hepatobiliary_system1.33034338
43MP0005167_abnormal_blood-brain_barrier1.32584825
44MP0005220_abnormal_exocrine_pancreas1.30638379
45MP0005670_abnormal_white_adipose1.30406154
46MP0003656_abnormal_erythrocyte_physiolo1.30269973
47MP0010030_abnormal_orbit_morphology1.30166095
48MP0005464_abnormal_platelet_physiology1.28675290
49MP0002118_abnormal_lipid_homeostasis1.25990641
50MP0009333_abnormal_splenocyte_physiolog1.25330865
51MP0000767_abnormal_smooth_muscle1.24878100
52MP0001958_emphysema1.23780926
53MP0004233_abnormal_muscle_weight1.23475152
54MP0002998_abnormal_bone_remodeling1.22321504
55MP0005503_abnormal_tendon_morphology1.22253735
56MP0001533_abnormal_skeleton_physiology1.20522026
57MP0005584_abnormal_enzyme/coenzyme_acti1.20161222
58MP0000598_abnormal_liver_morphology1.19227968
59MP0003329_amyloid_beta_deposits1.16835499
60MP0003075_altered_response_to1.15729647
61MP0005508_abnormal_skeleton_morphology1.15400635
62MP0001756_abnormal_urination1.13531435
63MP0005390_skeleton_phenotype1.13328157
64MP0003448_altered_tumor_morphology1.12351103
65MP0000343_altered_response_to1.11575256
66MP0000685_abnormal_immune_system1.11300172
67MP0000858_altered_metastatic_potential1.10039279
68MP0003172_abnormal_lysosome_physiology1.06922291
69MP0008469_abnormal_protein_level1.06580140
70MP0002148_abnormal_hypersensitivity_rea1.06442456
71MP0002254_reproductive_system_inflammat1.06351201
72MP0000013_abnormal_adipose_tissue1.06322733
73MP0004947_skin_inflammation1.05749321
74MP0000465_gastrointestinal_hemorrhage1.04210008
75MP0005275_abnormal_skin_tensile1.02258343
76MP0004019_abnormal_vitamin_homeostasis1.01346323
77MP0009053_abnormal_anal_canal1.00983122
78MP0001348_abnormal_lacrimal_gland0.98102572
79MP0004272_abnormal_basement_membrane0.97097860
80MP0000678_abnormal_parathyroid_gland0.97019886
81MP0005595_abnormal_vascular_smooth0.94739931
82MP0005076_abnormal_cell_differentiation0.94533331
83MP0005501_abnormal_skin_physiology0.93046224
84MP0002089_abnormal_postnatal_growth/wei0.92429509
85MP0000681_abnormal_thyroid_gland0.91555357
86MP0009764_decreased_sensitivity_to0.90943970
87MP0003634_abnormal_glial_cell0.90451620
88MP0001845_abnormal_inflammatory_respons0.87140044
89MP0002136_abnormal_kidney_physiology0.86404607
90MP0004130_abnormal_muscle_cell0.86292763
91MP0003303_peritoneal_inflammation0.84379677
92MP0005165_increased_susceptibility_to0.84263077
93MP0001853_heart_inflammation0.83651555
94MP0009785_altered_susceptibility_to0.83326288
95MP0005397_hematopoietic_system_phenotyp0.83318877
96MP0001545_abnormal_hematopoietic_system0.83318877
97MP0003795_abnormal_bone_structure0.83162052
98MP0004084_abnormal_cardiac_muscle0.82733913
99MP0005197_abnormal_uvea_morphology0.81747427
100MP0001915_intracranial_hemorrhage0.81133261
101MP0002933_joint_inflammation0.79978468
102MP0002419_abnormal_innate_immunity0.79635754
103MP0002060_abnormal_skin_morphology0.79134331
104MP0004858_abnormal_nervous_system0.78483726
105MP0002295_abnormal_pulmonary_circulatio0.78247152
106MP0000358_abnormal_cell_content/0.77111844
107MP0006082_CNS_inflammation0.76131496
108MP0005636_abnormal_mineral_homeostasis0.76030419
109MP0005000_abnormal_immune_tolerance0.75273022
110MP0010155_abnormal_intestine_physiology0.75055957
111MP0005666_abnormal_adipose_tissue0.74799841
112MP0001216_abnormal_epidermal_layer0.74251031
113MP0008004_abnormal_stomach_pH0.74238897
114MP0009763_increased_sensitivity_to0.73692210
115MP0002332_abnormal_exercise_endurance0.73593717
116MP0005330_cardiomyopathy0.72931804
117MP0000249_abnormal_blood_vessel0.72830077
118MP0000003_abnormal_adipose_tissue0.72545042
119MP0002896_abnormal_bone_mineralization0.72401076
120MP0005025_abnormal_response_to0.72375717
121MP0002269_muscular_atrophy0.71459676
122MP0005166_decreased_susceptibility_to0.70783599
123MP0005257_abnormal_intraocular_pressure0.70702954
124MP0001243_abnormal_dermal_layer0.70322186
125MP0003828_pulmonary_edema0.70131602
126MP0001849_ear_inflammation0.69538457
127MP0000747_muscle_weakness0.69464957
128MP0008873_increased_physiological_sensi0.68759615
129MP0000490_abnormal_crypts_of0.67799322
130MP0009278_abnormal_bone_marrow0.67716700
131MP0005387_immune_system_phenotype0.67100329
132MP0001790_abnormal_immune_system0.67100329
133MP0009642_abnormal_blood_homeostasis0.66790388
134MP0009384_cardiac_valve_regurgitation0.65794551
135MP0005375_adipose_tissue_phenotype0.65778774
136MP0000759_abnormal_skeletal_muscle0.65752872
137MP0003091_abnormal_cell_migration0.65742695
138MP0005164_abnormal_response_to0.64612612
139MP0002135_abnormal_kidney_morphology0.64506432
140MP0006036_abnormal_mitochondrial_physio0.62103375

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)4.33002987
2Abnormality of liposaccharide metabolism (HP:0010968)4.33002987
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.33002987
4Xanthomatosis (HP:0000991)3.89067567
5Protrusio acetabuli (HP:0003179)3.68237524
6Deep venous thrombosis (HP:0002625)3.64360164
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.34585911
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.20910987
9Hypoglycemic coma (HP:0001325)3.04789967
10Intrahepatic cholestasis (HP:0001406)3.02143068
11Premature rupture of membranes (HP:0001788)3.00538293
12Hyperammonemia (HP:0001987)2.96884189
13Hyperlipoproteinemia (HP:0010980)2.92514887
14Loss of speech (HP:0002371)2.87823585
15Urinary glycosaminoglycan excretion (HP:0003541)2.85122379
16Mucopolysacchariduria (HP:0008155)2.85122379
17Achilles tendon contracture (HP:0001771)2.83247789
18Nuclear cataract (HP:0100018)2.77243407
19Dysostosis multiplex (HP:0000943)2.76205067
20Hypoalphalipoproteinemia (HP:0003233)2.72511176
21Spinal rigidity (HP:0003306)2.70801774
22Polycythemia (HP:0001901)2.70689265
23Abnormality of glutamine family amino acid metabolism (HP:0010902)2.70011958
24Ketosis (HP:0001946)2.65113938
25Abnormality of fatty-acid metabolism (HP:0004359)2.60647774
26Short nail (HP:0001799)2.59408575
27Atrophic scars (HP:0001075)2.58563636
28Peritonitis (HP:0002586)2.56618683
29Hypolipoproteinemia (HP:0010981)2.55863784
30Asymmetric septal hypertrophy (HP:0001670)2.53942771
31Hypobetalipoproteinemia (HP:0003563)2.53809883
32Ankle contracture (HP:0006466)2.46278153
33Cerebral aneurysm (HP:0004944)2.45069032
34Ketoacidosis (HP:0001993)2.43561085
35Purpura (HP:0000979)2.42501571
36Complement deficiency (HP:0004431)2.41861532
37Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41444476
38Abnormality of polysaccharide metabolism (HP:0011012)2.41444476
39Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41444476
40Petechiae (HP:0000967)2.39140818
41Genu recurvatum (HP:0002816)2.37875914
42Ulnar bowing (HP:0003031)2.37655332
43Abnormality of dentin (HP:0010299)2.37167657
44Increased variability in muscle fiber diameter (HP:0003557)2.36238184
45Cervical subluxation (HP:0003308)2.35819559
46Increased cerebral lipofuscin (HP:0011813)2.35027692
47Late onset (HP:0003584)2.34931679
48Blue sclerae (HP:0000592)2.34650878
49Vertebral compression fractures (HP:0002953)2.33797263
50Systemic lupus erythematosus (HP:0002725)2.32373234
51Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.31883438
52Increased serum ferritin (HP:0003281)2.31777059
53Fragile skin (HP:0001030)2.31427953
54Dicarboxylic aciduria (HP:0003215)2.29843266
55Abnormality of dicarboxylic acid metabolism (HP:0010995)2.29843266
56Distal lower limb muscle weakness (HP:0009053)2.29815837
57Prolonged neonatal jaundice (HP:0006579)2.29365909
58Hand muscle atrophy (HP:0009130)2.27654309
59Back pain (HP:0003418)2.26875361
60Distal upper limb amyotrophy (HP:0007149)2.26065219
61Upper limb amyotrophy (HP:0009129)2.26065219
62Neurofibrillary tangles (HP:0002185)2.25552278
63Abnormality of complement system (HP:0005339)2.25235523
64Bladder diverticulum (HP:0000015)2.23600358
65Myocardial infarction (HP:0001658)2.22665500
66Abnormality of sulfur amino acid metabolism (HP:0004339)2.22586274
67Myoglobinuria (HP:0002913)2.22210572
68Gout (HP:0001997)2.20637853
69Wormian bones (HP:0002645)2.20325089
70Abnormality of proline metabolism (HP:0010907)2.20104057
71Hydroxyprolinuria (HP:0003080)2.20104057
72Distal lower limb amyotrophy (HP:0008944)2.19682450
73Increased connective tissue (HP:0009025)2.18365539
74Spastic diplegia (HP:0001264)2.17591239
75Abnormality of the nasal mucosa (HP:0000433)2.15425135
76Abnormality of the thoracic spine (HP:0100711)2.15083574
77Abnormality of the distal phalanges of the toes (HP:0010182)2.15063028
78Rhabdomyolysis (HP:0003201)2.13338122
79Abnormality of iron homeostasis (HP:0011031)2.13007593
80Malnutrition (HP:0004395)2.12160880
81Elbow flexion contracture (HP:0002987)2.10869497
82Sensorimotor neuropathy (HP:0007141)2.10618984
83Cerebral inclusion bodies (HP:0100314)2.07837480
84Abnormality of the intrinsic pathway (HP:0010989)2.07547367
85Aortic dissection (HP:0002647)2.05546508
86Beaking of vertebral bodies (HP:0004568)2.05432892
87Abnormal cartilage morphology (HP:0002763)2.05305432
88Abnormality of transition element cation homeostasis (HP:0011030)2.05272618
89Abnormality of purine metabolism (HP:0004352)2.03443481
90Abnormality of skeletal muscle fiber size (HP:0012084)2.02247484
91Generalized aminoaciduria (HP:0002909)2.02020818
92Increased neuronal autofluorescent lipopigment (HP:0002074)2.01569704
93Follicular hyperkeratosis (HP:0007502)2.01503481
94Interstitial pulmonary disease (HP:0006530)2.00086244
95Myopathic facies (HP:0002058)1.99149079
96Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98208575
97Soft skin (HP:0000977)1.96040929
98Broad distal phalanx of finger (HP:0009836)1.95710280
99Opisthotonus (HP:0002179)1.95667396
100Joint stiffness (HP:0001387)1.95593493
101Esophageal varix (HP:0002040)1.95232096
102Hyperacusis (HP:0010780)1.95203902
103Stridor (HP:0010307)1.95173861
104Mesangial abnormality (HP:0001966)1.93504734
105Upper motor neuron abnormality (HP:0002127)1.93410799
106Aortic aneurysm (HP:0004942)1.93330486
107Abnormality of the Achilles tendon (HP:0005109)1.93228336
108Stroke (HP:0001297)1.92663996
109Multiple enchondromatosis (HP:0005701)1.91943790
110Ragged-red muscle fibers (HP:0003200)1.91771938
111Abnormality of nucleobase metabolism (HP:0010932)1.91631559
112Abnormality of the fetal cardiovascular system (HP:0010948)1.91004634
113Abnormal umbilical cord blood vessels (HP:0011403)1.91004634
114Single umbilical artery (HP:0001195)1.91004634
115Hemorrhage of the eye (HP:0011885)1.90604649
116Progressive neurologic deterioration (HP:0002344)1.89217115
117Axonal loss (HP:0003447)1.88961331
118Mitral regurgitation (HP:0001653)1.88768485
119Vascular tortuosity (HP:0004948)1.88486492
120Abnormality of macrophages (HP:0004311)1.88244350
121Abnormality of the common coagulation pathway (HP:0010990)1.87672703
122Hyperglycinuria (HP:0003108)1.87187208
123Aneurysm (HP:0002617)1.85970452
124Nonimmune hydrops fetalis (HP:0001790)1.85970374
125Abnormal gallbladder physiology (HP:0012438)1.85656164
126Cholecystitis (HP:0001082)1.85656164
127Long toe (HP:0010511)1.85521466
128Abnormality of the umbilical cord (HP:0010881)1.84816177
129Thin bony cortex (HP:0002753)1.84663098
130Ectopia lentis (HP:0001083)1.84614441
131Slender build (HP:0001533)1.84594360
132Mildly elevated creatine phosphokinase (HP:0008180)1.84473955
133Global brain atrophy (HP:0002283)1.83651637
134Vacuolated lymphocytes (HP:0001922)1.80837493
135Right ventricular cardiomyopathy (HP:0011663)1.80566809
136Skin nodule (HP:0200036)1.80295870
137Abnormality of glycine metabolism (HP:0010895)1.80283887
138Abnormality of serine family amino acid metabolism (HP:0010894)1.80283887
139Thoracic kyphosis (HP:0002942)1.79924493
140Dilatation of the ascending aorta (HP:0005111)1.79068800
141Broad metatarsal (HP:0001783)1.78764872
142Recurrent gram-negative bacterial infections (HP:0005420)1.77798651
143Flat acetabular roof (HP:0003180)1.76976203
144Fatigue (HP:0012378)1.76170992
145Abnormality of the vasculature of the conjunctiva (HP:0008054)1.76111392
146Trismus (HP:0000211)1.75967508
147Difficulty climbing stairs (HP:0003551)1.75825026
148Hepatosplenomegaly (HP:0001433)1.75480599
149Biconcave vertebral bodies (HP:0004586)1.75182776
150Amyloidosis (HP:0011034)1.74758154
151Generalized amyotrophy (HP:0003700)1.74650612
152Hyperextensible skin (HP:0000974)1.74605467
153Abnormality of carpal bone ossification (HP:0006257)1.74325428
154Hypercholesterolemia (HP:0003124)1.73906038
155Mitral stenosis (HP:0001718)1.72786048
156Hyperparathyroidism (HP:0000843)1.72425926
157Abnormality of the acetabulum (HP:0003170)1.71670268
158Natal tooth (HP:0000695)1.71565884
159Joint laxity (HP:0001388)1.71553501
160Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71509800
161Supranuclear gaze palsy (HP:0000605)1.71454771
162Disproportionate tall stature (HP:0001519)1.70750415

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.75958999
2ERN14.52188912
3PKN23.50423504
4IRAK33.36804231
5BCKDK3.05971488
6TESK12.89104077
7TESK22.79450526
8KDR2.41255512
9PRPF4B2.33619278
10SMG12.28349035
11MST1R2.04199842
12ARAF1.92547926
13SCYL21.90354536
14PTK61.88152661
15TTN1.86311486
16MAP2K31.82407139
17MAP3K111.80946425
18TBK11.80111431
19MAP4K11.79691858
20SIK11.79624282
21LRRK21.78733919
22EEF2K1.75128647
23NME21.74765849
24KSR21.66680066
25BUB11.60054244
26MAP3K31.59495131
27PAK41.54941868
28MAP3K101.50919102
29FGFR41.49718978
30TIE11.45077273
31ZAP701.40187008
32PIM21.34694302
33TGFBR21.27371161
34MAP2K21.25808769
35RIPK11.21582423
36MAP3K21.20790364
37FES1.19837036
38RPS6KA41.18125181
39TAOK11.14840243
40ILK1.14730534
41PAK61.13285432
42STK101.09840337
43EPHA21.08778054
44EPHB11.07656848
45MAP3K81.06467293
46TGFBR11.02833480
47LIMK10.96776994
48PTK20.96362796
49MET0.95931799
50MOS0.91275632
51MAPKAPK30.89541031
52PDGFRA0.87788286
53BMX0.86318371
54MYLK0.86216716
55RPS6KA20.85515029
56MAP2K10.84070924
57PDK40.83821053
58PDK30.83821053
59TYK20.83070614
60RPS6KB20.82366385
61MAP3K10.82231099
62DDR20.82153592
63PRKCH0.81481617
64BRAF0.78761184
65CDC42BPA0.76162389
66SIK30.75438315
67NEK10.75190140
68BLK0.72427718
69EIF2AK10.71211810
70IRAK20.70060920
71RPS6KL10.69571402
72RPS6KC10.69571402
73FLT30.68981955
74PIK3CG0.67645438
75IKBKB0.67270463
76PAK20.64528703
77STK380.62455282
78FGFR10.62117927
79RET0.61355123
80LMTK20.59434956
81GRK70.57607632
82DYRK1B0.56716540
83CDK40.56380669
84CDK120.56297433
85GRK60.54600737
86DAPK30.54492407
87NTRK10.54475830
88PRKD30.54264400
89BTK0.53861094
90CAMKK20.53782029
91JAK20.53457535
92ABL20.52835197
93AURKA0.52655834
94TAOK20.51631760
95PDPK10.50405033
96CAMKK10.49182942
97HIPK20.48642099
98EIF2AK30.47819687
99MATK0.47641321
100IRAK40.47330639
101RPS6KA60.46317037
102MAPK110.46268233
103PRKG20.44344018
104MTOR0.43921984
105PDK20.43895144
106MAP3K140.43638229
107CSK0.43413773
108EPHB20.42389846
109MARK20.42209396
110PAK10.41941695
111PTK2B0.41201580
112MAP3K50.40676390
113NEK90.40181997
114PRKD20.39871954
115DAPK10.39814402
116FGR0.38289229
117ITK0.38107333
118CAMK2G0.36929087
119IKBKE0.35630072
120GSK3A0.35286384
121AKT20.35036971
122KSR10.35000042
123CLK10.34384645
124PIM10.34046469
125ICK0.33705739
126CDK60.33285655
127PRKD10.32442646
128ERBB40.31826547
129MAPKAPK20.31377328
130CAMK1D0.30049580
131CDK70.29980270
132CSF1R0.29588131
133LATS20.29150957
134NEK20.27741230
135JAK30.27499286
136PASK0.27071973
137ACVR1B0.26423054
138RAF10.26004780
139FER0.25179269

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.66479352
2Nitrogen metabolism_Homo sapiens_hsa009102.59507491
3Fatty acid degradation_Homo sapiens_hsa000712.55360995
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.49779842
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.34252902
6Selenocompound metabolism_Homo sapiens_hsa004502.17542863
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15805828
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.14443884
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.02625979
10Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.99281635
11Sulfur relay system_Homo sapiens_hsa041221.97443798
12Folate biosynthesis_Homo sapiens_hsa007901.95372064
13Vibrio cholerae infection_Homo sapiens_hsa051101.85325787
14Carbon metabolism_Homo sapiens_hsa012001.83528559
15Biosynthesis of amino acids_Homo sapiens_hsa012301.82895655
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82460302
17PPAR signaling pathway_Homo sapiens_hsa033201.82433474
18Complement and coagulation cascades_Homo sapiens_hsa046101.81220979
19Arginine biosynthesis_Homo sapiens_hsa002201.75518790
20Caffeine metabolism_Homo sapiens_hsa002321.74321669
21Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73499134
22Fatty acid metabolism_Homo sapiens_hsa012121.70697684
23Pentose phosphate pathway_Homo sapiens_hsa000301.70128792
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.68864790
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67778345
26Tryptophan metabolism_Homo sapiens_hsa003801.63997855
27Fat digestion and absorption_Homo sapiens_hsa049751.59390478
28Propanoate metabolism_Homo sapiens_hsa006401.57288952
29Peroxisome_Homo sapiens_hsa041461.56162261
30Glycosaminoglycan degradation_Homo sapiens_hsa005311.56063573
31Staphylococcus aureus infection_Homo sapiens_hsa051501.54662533
32Sulfur metabolism_Homo sapiens_hsa009201.51360648
33Pyruvate metabolism_Homo sapiens_hsa006201.49111731
34Acute myeloid leukemia_Homo sapiens_hsa052211.40950288
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.37785910
36Drug metabolism - other enzymes_Homo sapiens_hsa009831.34902979
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.30162953
38Bile secretion_Homo sapiens_hsa049761.28817776
39Osteoclast differentiation_Homo sapiens_hsa043801.25509653
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.21676332
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.18627241
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17955653
43TNF signaling pathway_Homo sapiens_hsa046681.17433688
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.17381346
45Butanoate metabolism_Homo sapiens_hsa006501.16560908
46Notch signaling pathway_Homo sapiens_hsa043301.12334285
47Lysosome_Homo sapiens_hsa041421.10933733
48Chemical carcinogenesis_Homo sapiens_hsa052041.08034614
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06095602
50Phagosome_Homo sapiens_hsa041451.05877414
51Histidine metabolism_Homo sapiens_hsa003401.03858745
52Bladder cancer_Homo sapiens_hsa052191.03054336
53Glutathione metabolism_Homo sapiens_hsa004801.02976118
54Galactose metabolism_Homo sapiens_hsa000521.02757576
55Other glycan degradation_Homo sapiens_hsa005111.02254977
56Sphingolipid metabolism_Homo sapiens_hsa006001.02072906
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01495850
58beta-Alanine metabolism_Homo sapiens_hsa004101.00594453
59Fructose and mannose metabolism_Homo sapiens_hsa000510.98103428
60N-Glycan biosynthesis_Homo sapiens_hsa005100.97156437
61Starch and sucrose metabolism_Homo sapiens_hsa005000.97140138
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95371776
63Focal adhesion_Homo sapiens_hsa045100.93941531
64Hepatitis C_Homo sapiens_hsa051600.92444256
65Legionellosis_Homo sapiens_hsa051340.91990397
66One carbon pool by folate_Homo sapiens_hsa006700.91244267
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90446535
68Prion diseases_Homo sapiens_hsa050200.89909739
69Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89067923
70Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.88289876
71Arginine and proline metabolism_Homo sapiens_hsa003300.87399509
72Collecting duct acid secretion_Homo sapiens_hsa049660.86273270
73Glycerolipid metabolism_Homo sapiens_hsa005610.86235934
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85861670
75VEGF signaling pathway_Homo sapiens_hsa043700.84980638
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84889203
77Endocytosis_Homo sapiens_hsa041440.83447149
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.82795813
79Pancreatic cancer_Homo sapiens_hsa052120.81388389
80Rheumatoid arthritis_Homo sapiens_hsa053230.80546651
81Tuberculosis_Homo sapiens_hsa051520.79683778
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.79607983
83Leishmaniasis_Homo sapiens_hsa051400.78993331
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78540326
85ABC transporters_Homo sapiens_hsa020100.75202423
86Phenylalanine metabolism_Homo sapiens_hsa003600.75114468
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.74954329
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.74719435
89Proteasome_Homo sapiens_hsa030500.74447711
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72384671
91Vitamin digestion and absorption_Homo sapiens_hsa049770.72118678
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71811695
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.71395618
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.70539111
95Hepatitis B_Homo sapiens_hsa051610.70064923
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68595748
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.67541521
98Synaptic vesicle cycle_Homo sapiens_hsa047210.65704074
99Small cell lung cancer_Homo sapiens_hsa052220.64103211
100Influenza A_Homo sapiens_hsa051640.64011429
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.63534130
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.63477005
103Sphingolipid signaling pathway_Homo sapiens_hsa040710.62381606
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61604856
105Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61301489
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.61053106
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.60959336
108Maturity onset diabetes of the young_Homo sapiens_hsa049500.59311360
109Shigellosis_Homo sapiens_hsa051310.57969752
110Endometrial cancer_Homo sapiens_hsa052130.57204610
111Non-small cell lung cancer_Homo sapiens_hsa052230.54876115
112AMPK signaling pathway_Homo sapiens_hsa041520.54154511
113Insulin resistance_Homo sapiens_hsa049310.51392268
114African trypanosomiasis_Homo sapiens_hsa051430.51334797
115Insulin signaling pathway_Homo sapiens_hsa049100.50433823
116Fatty acid elongation_Homo sapiens_hsa000620.50319530
117Protein digestion and absorption_Homo sapiens_hsa049740.49052063
118Steroid biosynthesis_Homo sapiens_hsa001000.48543634
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.47481860
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44494755
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43534831
122Thyroid cancer_Homo sapiens_hsa052160.43206671
123Retinol metabolism_Homo sapiens_hsa008300.41669447
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.39886294
125Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.38894912
126HTLV-I infection_Homo sapiens_hsa051660.38726933
127Vitamin B6 metabolism_Homo sapiens_hsa007500.38259855
128Pertussis_Homo sapiens_hsa051330.37593678
129Viral carcinogenesis_Homo sapiens_hsa052030.37386492
130Amoebiasis_Homo sapiens_hsa051460.37171215
131Chronic myeloid leukemia_Homo sapiens_hsa052200.36935405
132Apoptosis_Homo sapiens_hsa042100.36776507
133Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36672815
134Metabolic pathways_Homo sapiens_hsa011000.36341757
135Renin-angiotensin system_Homo sapiens_hsa046140.35935853
136Tyrosine metabolism_Homo sapiens_hsa003500.35378901
137Fatty acid biosynthesis_Homo sapiens_hsa000610.35280036
138Malaria_Homo sapiens_hsa051440.34938697
139Herpes simplex infection_Homo sapiens_hsa051680.33077288
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.32804243
141Salmonella infection_Homo sapiens_hsa051320.32250005
142Prolactin signaling pathway_Homo sapiens_hsa049170.31368344
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31209802
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.28710890
145HIF-1 signaling pathway_Homo sapiens_hsa040660.28257179
146ECM-receptor interaction_Homo sapiens_hsa045120.25939065
147Proteoglycans in cancer_Homo sapiens_hsa052050.25539819
148Toxoplasmosis_Homo sapiens_hsa051450.25431475

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