TMEM117

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)8.06832405
2central nervous system myelination (GO:0022010)8.06832405
3hemidesmosome assembly (GO:0031581)7.39832855
4desmosome organization (GO:0002934)5.99832523
5fatty acid elongation (GO:0030497)4.92648771
6bundle of His cell to Purkinje myocyte communication (GO:0086069)4.49749891
7photoreceptor cell differentiation (GO:0046530)4.38695303
8eye photoreceptor cell differentiation (GO:0001754)4.38695303
9COPII vesicle coating (GO:0048208)4.37799018
10ensheathment of neurons (GO:0007272)4.35170522
11axon ensheathment (GO:0008366)4.35170522
12myelination (GO:0042552)4.31327188
13long-chain fatty acid biosynthetic process (GO:0042759)4.10336510
14cell adhesion mediated by integrin (GO:0033627)4.10327656
15skin morphogenesis (GO:0043589)4.09496546
16establishment of mitochondrion localization (GO:0051654)4.04126870
17negative regulation of neurotransmitter transport (GO:0051589)4.02407858
18myelin maintenance (GO:0043217)3.99936821
19sensory perception of smell (GO:0007608)3.98268224
20glycerophospholipid catabolic process (GO:0046475)3.92535999
21collagen fibril organization (GO:0030199)3.91569902
22regulation of transforming growth factor beta2 production (GO:0032909)3.90381504
23melanin biosynthetic process (GO:0042438)3.81578541
24establishment of skin barrier (GO:0061436)3.72309109
25endodermal cell differentiation (GO:0035987)3.69873580
26COPI coating of Golgi vesicle (GO:0048205)3.61745105
27Golgi transport vesicle coating (GO:0048200)3.61745105
28cell-substrate junction assembly (GO:0007044)3.60436130
29regulation of water loss via skin (GO:0033561)3.54995149
30keratinocyte proliferation (GO:0043616)3.54990313
31melanin metabolic process (GO:0006582)3.53969972
32negative regulation of protein localization to cell surface (GO:2000009)3.46908869
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.46166973
34apical protein localization (GO:0045176)3.44467836
35negative regulation of chondrocyte differentiation (GO:0032331)3.41305912
36cholesterol biosynthetic process (GO:0006695)3.38506922
37asymmetric protein localization (GO:0008105)3.34002382
38negative regulation of keratinocyte proliferation (GO:0010839)3.33312877
39regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.28950744
40chondrocyte proliferation (GO:0035988)3.25819646
41response to methylmercury (GO:0051597)3.25565096
42response to redox state (GO:0051775)3.24218163
43magnesium ion transport (GO:0015693)3.23511471
44dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.22161117
45keratinization (GO:0031424)3.17432683
46sterol biosynthetic process (GO:0016126)3.15210322
47negative regulation of neurotransmitter secretion (GO:0046929)3.14740491
48regulation of cardioblast differentiation (GO:0051890)3.14122181
49protein polyglutamylation (GO:0018095)3.12447995
50keratan sulfate catabolic process (GO:0042340)3.11220497
51amyloid precursor protein metabolic process (GO:0042982)3.10255392
52basement membrane organization (GO:0071711)3.10057326
53regulation of integrin-mediated signaling pathway (GO:2001044)3.08616479
54secondary metabolite biosynthetic process (GO:0044550)3.06966857
55glomerular basement membrane development (GO:0032836)3.06362477
56mesenchymal-epithelial cell signaling (GO:0060638)3.02232128
57kidney mesenchyme development (GO:0072074)3.01942854
58apoptotic cell clearance (GO:0043277)2.97665672
59protein retention in ER lumen (GO:0006621)2.97310855
60regulation of collateral sprouting (GO:0048670)2.96722433
61cellular potassium ion homeostasis (GO:0030007)2.94345665
62neuronal action potential propagation (GO:0019227)2.93753921
63cell migration involved in heart development (GO:0060973)2.93601971
64positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.92773233
65maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92278823
66collagen metabolic process (GO:0032963)2.90735390
67chondrocyte development (GO:0002063)2.89090470
68response to pheromone (GO:0019236)2.89002660
69positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.88943131
70multicellular organismal macromolecule metabolic process (GO:0044259)2.86546633
71negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.85861230
72extracellular matrix disassembly (GO:0022617)2.84596763
73regulation of keratinocyte proliferation (GO:0010837)2.84207704
74synaptic vesicle maturation (GO:0016188)2.83987168
75collagen catabolic process (GO:0030574)2.83217804
76dopamine biosynthetic process (GO:0042416)2.81514871
77potassium ion import (GO:0010107)2.78829392
78creatine metabolic process (GO:0006600)2.78772397
79polarized epithelial cell differentiation (GO:0030859)2.77798610
80substantia nigra development (GO:0021762)2.77797220
81potassium ion homeostasis (GO:0055075)2.77105621
82metanephric mesenchyme development (GO:0072075)2.76671437
83multicellular organismal catabolic process (GO:0044243)2.76659349
84regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.76427146
85isoprenoid biosynthetic process (GO:0008299)2.74883969
86regulation of female gonad development (GO:2000194)2.74323558
87multicellular organismal metabolic process (GO:0044236)2.74274321
88barbed-end actin filament capping (GO:0051016)2.73821259
89neuron cell-cell adhesion (GO:0007158)2.73401918
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.72327771
91neuron remodeling (GO:0016322)2.71111123
92peptidyl-proline hydroxylation (GO:0019511)2.70507552
93regulation of lipoprotein metabolic process (GO:0050746)2.70484383
94regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.69814711
95sensory perception of chemical stimulus (GO:0007606)2.68735651
96synaptic vesicle exocytosis (GO:0016079)2.67907075
97protein localization to endosome (GO:0036010)2.65942708
98protein hydroxylation (GO:0018126)2.65426868
99gap junction assembly (GO:0016264)2.65272427
100sequestering of extracellular ligand from receptor (GO:0035581)2.64088667
101detection of temperature stimulus involved in sensory perception (GO:0050961)2.63381410
102detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63381410
103keratinocyte differentiation (GO:0030216)2.63037579
104positive regulation of odontogenesis (GO:0042482)2.62530807
105adult walking behavior (GO:0007628)2.62376221
106smooth muscle tissue development (GO:0048745)2.61958131
107regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.61759754
108positive regulation of oligodendrocyte differentiation (GO:0048714)2.60916287
109microtubule severing (GO:0051013)2.59574820
110negative regulation of catenin import into nucleus (GO:0035414)2.58173290
111vesicle coating (GO:0006901)2.57093299
112regulation of early endosome to late endosome transport (GO:2000641)2.56868182
113regulation of autophagic vacuole assembly (GO:2000785)2.56427992
114regulation of transforming growth factor beta1 production (GO:0032908)2.54563914
115positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.52963991
116positive regulation of potassium ion transport (GO:0043268)2.52903550
117midgut development (GO:0007494)2.51792972
118long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.50634948
119protein palmitoylation (GO:0018345)2.50197041
120negative regulation of potassium ion transmembrane transport (GO:1901380)2.49524097
121protein neddylation (GO:0045116)2.49234969
122endothelial cell morphogenesis (GO:0001886)2.48524513
123oligodendrocyte differentiation (GO:0048709)2.48084204
124negative regulation of fatty acid transport (GO:2000192)2.47380582
125mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.47046627
126L-amino acid import (GO:0043092)2.47017313
127negative regulation of cartilage development (GO:0061037)2.46993002
128organ induction (GO:0001759)2.46810526
129neuronal action potential (GO:0019228)2.46748299
130establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.46699981
131mitochondrion transport along microtubule (GO:0047497)2.46699981
132muscle cell cellular homeostasis (GO:0046716)2.46495985
133regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.43750863
134epidermis development (GO:0008544)2.43622393
135presynaptic membrane organization (GO:0097090)2.42616001
136cerebral cortex radially oriented cell migration (GO:0021799)2.42041008
137long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.41900899
138neurotransmitter uptake (GO:0001504)2.41707932
139mating behavior (GO:0007617)2.41394974
140paraxial mesoderm development (GO:0048339)2.41362782
141planar cell polarity pathway involved in neural tube closure (GO:0090179)2.40029599
142hypotonic response (GO:0006971)2.39752046
143glutamate secretion (GO:0014047)2.39467838
144detection of temperature stimulus (GO:0016048)2.39241842
145neurofilament cytoskeleton organization (GO:0060052)2.37721294
146axonal fasciculation (GO:0007413)2.37558503
147limb bud formation (GO:0060174)2.37380117
148negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.36999229
149neuron recognition (GO:0008038)2.35816238
150regulation of chondrocyte differentiation (GO:0032330)2.34895281
151cellular response to vitamin (GO:0071295)2.34702420
152peptidyl-tyrosine autophosphorylation (GO:0038083)2.34219355
153peptide cross-linking (GO:0018149)2.33809251
154renal filtration (GO:0097205)2.32495099
155extracellular fibril organization (GO:0043206)2.32351157
156extracellular structure organization (GO:0043062)2.32212565
157extracellular matrix organization (GO:0030198)2.32171885
158peptidyl-cysteine modification (GO:0018198)2.32017420
159cochlea morphogenesis (GO:0090103)2.31987950
160regulation of synaptic vesicle exocytosis (GO:2000300)2.31153076
161positive regulation of mesenchymal cell proliferation (GO:0002053)2.30739693
162wound healing, spreading of epidermal cells (GO:0035313)2.30249682
163phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.29508829
164membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.28191668
165branching involved in mammary gland duct morphogenesis (GO:0060444)2.28028344
166bone trabecula formation (GO:0060346)2.27728165
167axon development (GO:0061564)2.27375648
168establishment of planar polarity (GO:0001736)2.25875626
169establishment of tissue polarity (GO:0007164)2.25875626
170enteric nervous system development (GO:0048484)2.25498821
171positive regulation of potassium ion transmembrane transport (GO:1901381)2.25230246
172negative regulation of inclusion body assembly (GO:0090084)2.25132827
173positive regulation of neurological system process (GO:0031646)2.23821284
174mammary gland epithelial cell proliferation (GO:0033598)2.23507288
175ventricular cardiac muscle cell development (GO:0055015)2.23481311
176type B pancreatic cell proliferation (GO:0044342)2.23349363
177epithelial cell-cell adhesion (GO:0090136)2.23075743
178fatty-acyl-CoA metabolic process (GO:0035337)2.22739265
179regulation of metalloenzyme activity (GO:0048552)2.22376655
180embryonic skeletal joint morphogenesis (GO:0060272)2.22222276
181glomerular visceral epithelial cell development (GO:0072015)2.22131924
182embryonic cranial skeleton morphogenesis (GO:0048701)2.21681750
183calcium-mediated signaling using intracellular calcium source (GO:0035584)2.21620188
184sodium ion export (GO:0071436)2.21325463
185regulation of axon extension involved in axon guidance (GO:0048841)2.21301600
186negative regulation of axonogenesis (GO:0050771)2.20910333
187heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.20883784
188negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.20450537
189membrane protein ectodomain proteolysis (GO:0006509)2.19790832
190phosphatidylinositol acyl-chain remodeling (GO:0036149)2.19745427
191peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.19674055
192cellular response to vitamin D (GO:0071305)2.19506662
193fatty-acyl-CoA biosynthetic process (GO:0046949)2.18921792
194peripheral nervous system development (GO:0007422)2.18842359
195gamma-aminobutyric acid signaling pathway (GO:0007214)2.18613449
196ER overload response (GO:0006983)2.18557319
197regulation of vacuole organization (GO:0044088)2.18426170
198detection of calcium ion (GO:0005513)2.18094624
199microtubule polymerization or depolymerization (GO:0031109)2.16286749
200organelle transport along microtubule (GO:0072384)2.16046136

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.49072353
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.59576637
3EZH2_22144423_ChIP-Seq_EOC_Human3.53128266
4SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.44031764
5PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.17703085
6GBX2_23144817_ChIP-Seq_PC3_Human2.74666769
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44616156
8SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.38725946
9SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.38725946
10AR_21909140_ChIP-Seq_LNCAP_Human2.32562993
11CLOCK_20551151_ChIP-Seq_293T_Human2.21115809
12TP53_18474530_ChIP-ChIP_U2OS_Human2.18287922
13CJUN_26792858_Chip-Seq_BT549_Human2.18251778
14TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16773538
15* BRD4_25478319_ChIP-Seq_HGPS_Human2.16240028
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.15838255
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13959795
18CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.13747406
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.10902447
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10827483
21VDR_22108803_ChIP-Seq_LS180_Human2.04174000
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03978259
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03978259
24SOX9_24532713_ChIP-Seq_HFSC_Mouse2.02671251
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96899755
26* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96140301
27* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.89520367
28PPAR_26484153_Chip-Seq_NCI-H1993_Human1.87759101
29CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.86860506
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85054535
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.79619184
32EZH2_27304074_Chip-Seq_ESCs_Mouse1.78009945
33SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75983167
34OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73234916
35JARID2_20075857_ChIP-Seq_MESCs_Mouse1.72670945
36EED_16625203_ChIP-ChIP_MESCs_Mouse1.71588498
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.67714442
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.67296446
39AR_21572438_ChIP-Seq_LNCaP_Human1.66770215
40TAF15_26573619_Chip-Seq_HEK293_Human1.63527785
41SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63396489
42SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61705759
43RNF2_27304074_Chip-Seq_ESCs_Mouse1.58427936
44SMAD_19615063_ChIP-ChIP_OVARY_Human1.57125947
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.56557451
46GATA1_22025678_ChIP-Seq_K562_Human1.56498483
47HIF1A_21447827_ChIP-Seq_MCF-7_Human1.55900370
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55725420
49UBF1/2_26484160_Chip-Seq_HMECs_Human1.55724869
50TP53_16413492_ChIP-PET_HCT116_Human1.53671027
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.53642242
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53440606
53TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52055764
54* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51376352
55EP300_21415370_ChIP-Seq_HL-1_Mouse1.49980706
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49461303
57* TP63_23658742_ChIP-Seq_EP156T_Human1.48902718
58RBPJ_22232070_ChIP-Seq_NCS_Mouse1.48018512
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.46265315
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45917257
61DROSHA_22980978_ChIP-Seq_HELA_Human1.44548475
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43484476
63SOX2_20726797_ChIP-Seq_SW620_Human1.42488858
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.39714719
65* STAT3_23295773_ChIP-Seq_U87_Human1.38923356
66REST_21632747_ChIP-Seq_MESCs_Mouse1.38361210
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.38110615
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38105788
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.37779289
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.35579273
71TBX20_22080862_ChIP-Seq_HEART_Mouse1.34442388
72TBX20_22328084_ChIP-Seq_HEART_Mouse1.34442388
73* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33353695
74SMAD4_21799915_ChIP-Seq_A2780_Human1.33162402
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.32987284
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.32984772
77ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31947922
78CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30894443
79KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.30883425
80MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.30374490
81TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29466858
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.29256547
83* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28758128
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28734857
85* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.28215426
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.28176726
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.28080411
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27005561
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26891012
90ESR1_21235772_ChIP-Seq_MCF-7_Human1.26874509
91TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.26301318
92* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26233714
93ZNF217_24962896_ChIP-Seq_MCF-7_Human1.25351327
94ESR1_20079471_ChIP-ChIP_T-47D_Human1.25030245
95SALL1_21062744_ChIP-ChIP_HESCs_Human1.23908311
96NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.21756403
97* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20805162
98ER_23166858_ChIP-Seq_MCF-7_Human1.20386392
99LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19883451
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19814421
101* P300_19829295_ChIP-Seq_ESCs_Human1.19227354
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.18368588
103RNF2_27304074_Chip-Seq_NSC_Mouse1.17818846
104* PRDM14_20953172_ChIP-Seq_ESCs_Human1.17738761
105STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16830525
106TCF4_18268006_ChIP-ChIP_LS174T_Human1.16663189
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15928223
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.14988229
109* SOX2_21211035_ChIP-Seq_LN229_Gbm1.13909577
110NANOG_18555785_Chip-Seq_ESCs_Mouse1.13535085
111UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.13446795
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12798019
113PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11831626
114BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11772012
115PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11163680
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11125921
117WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10656701
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.09675106
119LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08873836
120REST_18959480_ChIP-ChIP_MESCs_Mouse1.08818189
121PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.08508707
122* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08034352
123* TAL1_26923725_Chip-Seq_HPCs_Mouse1.07657422
124TRIM28_21343339_ChIP-Seq_HEK293_Human1.07414623
125GATA2_21666600_ChIP-Seq_HMVEC_Human1.07050144
126CDX2_20551321_ChIP-Seq_CACO-2_Human1.06357388
127PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05842165
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05581297
129* TCF4_23295773_ChIP-Seq_U87_Human1.03637291
130TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03465683
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03465683
132WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03177964
133RARB_27405468_Chip-Seq_BRAIN_Mouse1.02777133
134KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02670730
135TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.01699945
136ARNT_22903824_ChIP-Seq_MCF-7_Human1.01644756
137ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01435294
138ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.99869836
139* SMAD4_21741376_ChIP-Seq_EPCs_Human0.99408989
140ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97159002
141AHR_22903824_ChIP-Seq_MCF-7_Human0.96811564
142FUS_26573619_Chip-Seq_HEK293_Human0.96718940
143TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96690602
144ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96413438
145NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.96256360
146WT1_19549856_ChIP-ChIP_CCG9911_Human0.96073487
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95918270
148ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95518982
149CMYC_18555785_Chip-Seq_ESCs_Mouse0.94760652
150NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94466027
151GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94396684
152* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93956242
153* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93956242
154AR_25329375_ChIP-Seq_VCAP_Human0.93950496
155RUNX2_22187159_ChIP-Seq_PCA_Human0.93668587
156ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92767674
157GATA3_24758297_ChIP-Seq_MCF-7_Human0.92113312
158CDX2_22108803_ChIP-Seq_LS180_Human0.91936571
159KDM2B_26808549_Chip-Seq_REH_Human0.91757030
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.90811075
161TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90017713
162FOXA2_19822575_ChIP-Seq_HepG2_Human0.89767587
163GATA4_21415370_ChIP-Seq_HL-1_Mouse0.89546303
164SOX2_19829295_ChIP-Seq_ESCs_Human0.88907905
165NANOG_19829295_ChIP-Seq_ESCs_Human0.88907905
166KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88600612
167RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88599971
168ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88158774
169RING1B_27294783_Chip-Seq_NPCs_Mouse0.87292917
170SUZ12_18555785_Chip-Seq_ESCs_Mouse0.86944551
171TP53_22127205_ChIP-Seq_IMR90_Human0.84513441
172* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.84109413
173ATF3_27146783_Chip-Seq_COLON_Human0.83338328
174JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83265186
175ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81524597

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.53553163
2MP0005275_abnormal_skin_tensile4.89247712
3MP0004270_analgesia4.04882514
4MP0003705_abnormal_hypodermis_morpholog3.68066829
5MP0005257_abnormal_intraocular_pressure3.36553500
6MP0005503_abnormal_tendon_morphology3.09107642
7MP0010234_abnormal_vibrissa_follicle3.05777043
8MP0004272_abnormal_basement_membrane3.02860168
9MP0000920_abnormal_myelination2.84933605
10MP0003941_abnormal_skin_development2.84155548
11MP0003880_abnormal_central_pattern2.80387207
12MP0002877_abnormal_melanocyte_morpholog2.61719753
13MP0001485_abnormal_pinna_reflex2.52634065
14MP0003329_amyloid_beta_deposits2.41437980
15MP0002272_abnormal_nervous_system2.41284341
16MP0005408_hypopigmentation2.40833302
17MP0002734_abnormal_mechanical_nocicepti2.40730077
18MP0002060_abnormal_skin_morphology2.24837882
19MP0004885_abnormal_endolymph2.22549203
20MP0004145_abnormal_muscle_electrophysio2.21851376
21MP0000372_irregular_coat_pigmentation2.21753579
22MP0005423_abnormal_somatic_nervous2.19797710
23MP0004043_abnormal_pH_regulation2.16554921
24MP0003566_abnormal_cell_adhesion2.09481368
25MP0003950_abnormal_plasma_membrane2.06406429
26MP0001984_abnormal_olfaction2.06201653
27MP0004859_abnormal_synaptic_plasticity2.06157720
28MP0001529_abnormal_vocalization2.03363546
29MP0000462_abnormal_digestive_system2.03119336
30MP0001905_abnormal_dopamine_level2.01076990
31MP0001486_abnormal_startle_reflex1.96940934
32MP0004134_abnormal_chest_morphology1.89360806
33MP0004742_abnormal_vestibular_system1.86976075
34MP0002796_impaired_skin_barrier1.84771491
35MP0001958_emphysema1.83225932
36MP0003635_abnormal_synaptic_transmissio1.75819903
37MP0000569_abnormal_digit_pigmentation1.75788549
38MP0002735_abnormal_chemical_nociception1.74828103
39MP0005409_darkened_coat_color1.74390202
40MP0006054_spinal_hemorrhage1.68488425
41MP0003646_muscle_fatigue1.68368477
42MP0002837_dystrophic_cardiac_calcinosis1.67636978
43MP0000778_abnormal_nervous_system1.66338879
44MP0009384_cardiac_valve_regurgitation1.66024411
45MP0002064_seizures1.62992145
46MP0001970_abnormal_pain_threshold1.62652179
47MP0002229_neurodegeneration1.62358927
48MP0001963_abnormal_hearing_physiology1.61897813
49MP0000015_abnormal_ear_pigmentation1.60587107
50MP0004142_abnormal_muscle_tone1.60516082
51MP0001968_abnormal_touch/_nociception1.59376658
52MP0003279_aneurysm1.59077594
53MP0002184_abnormal_innervation1.58969375
54MP0000751_myopathy1.58620505
55MP0002733_abnormal_thermal_nociception1.58503921
56MP0002896_abnormal_bone_mineralization1.56327123
57MP0009053_abnormal_anal_canal1.56101751
58MP0003634_abnormal_glial_cell1.55731683
59MP0001299_abnormal_eye_distance/1.55005142
60MP0000747_muscle_weakness1.52878688
61MP0006276_abnormal_autonomic_nervous1.51599731
62MP0005023_abnormal_wound_healing1.50543022
63MP0000955_abnormal_spinal_cord1.50007115
64MP0010352_gastrointestinal_tract_polyps1.49197769
65MP0003879_abnormal_hair_cell1.48814215
66MP0000013_abnormal_adipose_tissue1.47424732
67MP0004036_abnormal_muscle_relaxation1.45688443
68MP0001661_extended_life_span1.43010478
69MP0005248_abnormal_Harderian_gland1.41672910
70MP0003136_yellow_coat_color1.39384721
71MP0005508_abnormal_skeleton_morphology1.37892126
72MP0005646_abnormal_pituitary_gland1.35375174
73MP0002882_abnormal_neuron_morphology1.35201243
74MP0010030_abnormal_orbit_morphology1.33503296
75MP0002067_abnormal_sensory_capabilities1.33122025
76MP0002736_abnormal_nociception_after1.32702609
77MP0000749_muscle_degeneration1.29898130
78MP0002063_abnormal_learning/memory/cond1.28682107
79MP0005197_abnormal_uvea_morphology1.28490352
80MP0001542_abnormal_bone_strength1.28242570
81MP0002752_abnormal_somatic_nervous1.28022580
82MP0003690_abnormal_glial_cell1.27691971
83MP0003453_abnormal_keratinocyte_physiol1.26802845
84MP0003632_abnormal_nervous_system1.26558432
85MP0000733_abnormal_muscle_development1.26034404
86MP0009745_abnormal_behavioral_response1.22872141
87MP0009046_muscle_twitch1.21823893
88MP0002572_abnormal_emotion/affect_behav1.21189361
89MP0001216_abnormal_epidermal_layer1.20651954
90MP0000371_diluted_coat_color1.19661620
91MP0000579_abnormal_nail_morphology1.17879557
92MP0003191_abnormal_cellular_cholesterol1.17668337
93MP0005451_abnormal_body_composition1.17282752
94MP0005645_abnormal_hypothalamus_physiol1.17132617
95MP0001243_abnormal_dermal_layer1.17123847
96MP0002108_abnormal_muscle_morphology1.16417430
97MP0004381_abnormal_hair_follicle1.16364109
98MP0005501_abnormal_skin_physiology1.15619902
99MP0006072_abnormal_retinal_apoptosis1.14467437
100MP0000026_abnormal_inner_ear1.13444669
101MP0000467_abnormal_esophagus_morphology1.13093036
102MP0000003_abnormal_adipose_tissue1.12525972
103MP0002066_abnormal_motor_capabilities/c1.12350116
104MP0003631_nervous_system_phenotype1.11160789
105MP0002102_abnormal_ear_morphology1.10941997
106MP0009780_abnormal_chondrocyte_physiolo1.09280801
107MP0005171_absent_coat_pigmentation1.08526567
108MP0003385_abnormal_body_wall1.08396136
109MP0005551_abnormal_eye_electrophysiolog1.06775091
110MP0000377_abnormal_hair_follicle1.06244470
111MP0001502_abnormal_circadian_rhythm1.04409367
112MP0010368_abnormal_lymphatic_system1.03788595
113MP0003787_abnormal_imprinting1.03117370
114MP0008569_lethality_at_weaning1.02910361
115MP0001346_abnormal_lacrimal_gland1.02891465
116MP0000427_abnormal_hair_cycle1.02868378
117MP0002095_abnormal_skin_pigmentation1.02444844
118MP0009250_abnormal_appendicular_skeleto1.00250885
119MP0005410_abnormal_fertilization0.99651485
120MP0000534_abnormal_ureter_morphology0.99620643
121MP0003718_maternal_effect0.99572767
122MP0003633_abnormal_nervous_system0.99374260
123MP0005174_abnormal_tail_pigmentation0.99289743
124MP0010678_abnormal_skin_adnexa0.99174905
125MP0005623_abnormal_meninges_morphology0.98518844
126MP0000767_abnormal_smooth_muscle0.98474649
127MP0004924_abnormal_behavior0.97289189
128MP0005386_behavior/neurological_phenoty0.97289189
129MP0001501_abnormal_sleep_pattern0.96319945
130MP0010771_integument_phenotype0.95756022
131MP0005360_urolithiasis0.94322906
132MP0008789_abnormal_olfactory_epithelium0.94190170
133MP0003195_calcinosis0.93805306
134MP0003283_abnormal_digestive_organ0.93556190
135MP0000538_abnormal_urinary_bladder0.93422291
136MP0004084_abnormal_cardiac_muscle0.92519944
137MP0001849_ear_inflammation0.92203927
138MP0005058_abnormal_lysosome_morphology0.92115903
139MP0002282_abnormal_trachea_morphology0.91831691
140MP0002177_abnormal_outer_ear0.91767188
141MP0003806_abnormal_nucleotide_metabolis0.90132456
142MP0001440_abnormal_grooming_behavior0.89850869
143MP0001986_abnormal_taste_sensitivity0.89771910
144MP0005187_abnormal_penis_morphology0.89639033
145MP0002909_abnormal_adrenal_gland0.89012775
146MP0003137_abnormal_impulse_conducting0.88226648
147MP0002098_abnormal_vibrissa_morphology0.86781306
148MP0003091_abnormal_cell_migration0.86448759
149MP0005193_abnormal_anterior_eye0.85977710
150MP0002233_abnormal_nose_morphology0.85924352
151MP0003937_abnormal_limbs/digits/tail_de0.83604838
152MP0000604_amyloidosis0.83590800
153MP0005620_abnormal_muscle_contractility0.83053662
154MP0001186_pigmentation_phenotype0.82061224
155MP0004185_abnormal_adipocyte_glucose0.81463054
156MP0000762_abnormal_tongue_morphology0.81443637
157MP0004811_abnormal_neuron_physiology0.79876781
158MP0002557_abnormal_social/conspecific_i0.79683366
159MP0002075_abnormal_coat/hair_pigmentati0.78317098
160MP0010386_abnormal_urinary_bladder0.78258536
161MP0009840_abnormal_foam_cell0.77421251
162MP0002938_white_spotting0.76987930
163MP0004215_abnormal_myocardial_fiber0.76531668
164MP0006138_congestive_heart_failure0.76429038
165MP0004858_abnormal_nervous_system0.76310301
166MP0005195_abnormal_posterior_eye0.75896323
167MP0005330_cardiomyopathy0.75624006
168MP0002234_abnormal_pharynx_morphology0.75065749
169MP0000759_abnormal_skeletal_muscle0.74994051
170MP0002115_abnormal_skeleton_extremities0.74825436
171MP0001664_abnormal_digestion0.74792232
172MP0002295_abnormal_pulmonary_circulatio0.73708363
173MP0003755_abnormal_palate_morphology0.72544507
174MP0000432_abnormal_head_morphology0.72541934
175MP0000163_abnormal_cartilage_morphology0.70022233
176MP0000383_abnormal_hair_follicle0.68955312
177MP0004782_abnormal_surfactant_physiolog0.68427183
178MP0002009_preneoplasia0.68368571
179MP0001879_abnormal_lymphatic_vessel0.66643980
180MP0000647_abnormal_sebaceous_gland0.66518080
181MP0004233_abnormal_muscle_weight0.66080969
182MP0004087_abnormal_muscle_fiber0.64869993
183MP0000627_abnormal_mammary_gland0.63736631
184MP0002109_abnormal_limb_morphology0.63514391

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.48114523
2Atrophic scars (HP:0001075)5.25514715
3Protrusio acetabuli (HP:0003179)4.62707723
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.23476638
5Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.23476638
6Insidious onset (HP:0003587)4.19330402
7Termporal pattern (HP:0011008)4.19330402
8Aortic dissection (HP:0002647)4.10433316
9Neurofibrillary tangles (HP:0002185)3.93270455
10Epiphyseal dysplasia (HP:0002656)3.93131391
11Abnormality of nail color (HP:0100643)3.91497326
12Vascular tortuosity (HP:0004948)3.76351542
13Onycholysis (HP:0001806)3.73066366
14Arterial tortuosity (HP:0005116)3.71775048
15Hypoplastic ischia (HP:0003175)3.67006403
16Alopecia of scalp (HP:0002293)3.44631504
17Irregular epiphyses (HP:0010582)3.44074299
18Plantar hyperkeratosis (HP:0007556)3.36817516
19Abnormality of the ischium (HP:0003174)3.33743135
20Abnormality of the corticospinal tract (HP:0002492)3.33035457
21Follicular hyperkeratosis (HP:0007502)3.31853931
22Pheochromocytoma (HP:0002666)3.27644672
23Retinal dysplasia (HP:0007973)3.16269241
24Peripheral hypomyelination (HP:0007182)3.15166266
25Spondylolisthesis (HP:0003302)3.12014332
26Fragile skin (HP:0001030)3.11464893
27Right ventricular cardiomyopathy (HP:0011663)3.08241819
28Pterygium (HP:0001059)3.01881641
29Muscle hypertrophy of the lower extremities (HP:0008968)2.99278344
30Soft skin (HP:0000977)2.98744500
31Osteolytic defects of the hand bones (HP:0009699)2.97045961
32Osteolytic defects of the phalanges of the hand (HP:0009771)2.97045961
33Milia (HP:0001056)2.94687835
34Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.92568902
35Wormian bones (HP:0002645)2.92372798
36Myokymia (HP:0002411)2.90678051
37Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.88035492
38Fragile nails (HP:0001808)2.85444971
39Onion bulb formation (HP:0003383)2.82222102
40Supranuclear gaze palsy (HP:0000605)2.81910029
41Cerebral inclusion bodies (HP:0100314)2.81747518
42Ankle clonus (HP:0011448)2.79789681
43Bladder diverticulum (HP:0000015)2.76601260
44Palmoplantar hyperkeratosis (HP:0000972)2.74750520
45Aortic aneurysm (HP:0004942)2.74648959
46Natal tooth (HP:0000695)2.74240339
47Neuroendocrine neoplasm (HP:0100634)2.71428133
48Calf muscle hypertrophy (HP:0008981)2.70173827
49Palmar hyperkeratosis (HP:0010765)2.69501301
50Abnormal auditory evoked potentials (HP:0006958)2.66313366
51Vertebral compression fractures (HP:0002953)2.65684480
52Muscle fiber splitting (HP:0003555)2.64222492
53Coronal craniosynostosis (HP:0004440)2.57234136
54Mitral stenosis (HP:0001718)2.53892628
55Cerebral hypomyelination (HP:0006808)2.48117769
56Segmental peripheral demyelination/remyelination (HP:0003481)2.47183298
57Alacrima (HP:0000522)2.45821365
58Spastic gait (HP:0002064)2.44584097
59Delayed epiphyseal ossification (HP:0002663)2.42969706
60Abnormality of the umbilical cord (HP:0010881)2.42216655
61Thick nail (HP:0001805)2.39887608
62Abnormality of dentin (HP:0010299)2.39032775
63Enlarged epiphyses (HP:0010580)2.38989864
64Hypoplasia of the iris (HP:0007676)2.35684876
65Hypokalemic alkalosis (HP:0001949)2.35300324
66Popliteal pterygium (HP:0009756)2.35233450
67Abnormalities of placenta or umbilical cord (HP:0001194)2.34770829
68Metabolic alkalosis (HP:0200114)2.34606875
69Spinal cord lesions (HP:0100561)2.30873246
70Syringomyelia (HP:0003396)2.30873246
71Atonic seizures (HP:0010819)2.30392462
72Foot dorsiflexor weakness (HP:0009027)2.29922364
73Vitreoretinal degeneration (HP:0000655)2.28636152
74Elbow flexion contracture (HP:0002987)2.28631562
75Type 1 muscle fiber predominance (HP:0003803)2.27489899
76Neonatal short-limb short stature (HP:0008921)2.24243883
77Abnormality of the acetabulum (HP:0003170)2.23786502
78Aplasia involving bones of the extremities (HP:0009825)2.23659704
79Aplasia involving bones of the upper limbs (HP:0009823)2.23659704
80Aplasia of the phalanges of the hand (HP:0009802)2.23659704
81Ankle contracture (HP:0006466)2.22004400
82Hammertoe (HP:0001765)2.21103061
83Dysmetria (HP:0001310)2.16715167
84Ulnar claw (HP:0001178)2.16226505
85Scanning speech (HP:0002168)2.15488894
86Abnormality of the phalanges of the 2nd finger (HP:0009541)2.15220914
87Microglossia (HP:0000171)2.14775473
88Small epiphyses (HP:0010585)2.14574966
89White forelock (HP:0002211)2.14080249
90Limb dystonia (HP:0002451)2.13330216
91Nonprogressive disorder (HP:0003680)2.13298651
92Thin bony cortex (HP:0002753)2.12263926
93Type II lissencephaly (HP:0007260)2.11531846
94Cardiovascular calcification (HP:0011915)2.10253525
95Patchy hypopigmentation of hair (HP:0011365)2.09508184
96Ridged nail (HP:0001807)2.07411508
97Calcaneovalgus deformity (HP:0001848)2.07329388
98Abnormality of the foot musculature (HP:0001436)2.03078999
99Abnormality of the vitreous humor (HP:0004327)2.02978513
100Morphological abnormality of the inner ear (HP:0011390)2.02502486
101Flat capital femoral epiphysis (HP:0003370)2.02159991
102Gowers sign (HP:0003391)2.02088902
103Action tremor (HP:0002345)2.01695051
104Abnormality of placental membranes (HP:0011409)2.01694379
105Amniotic constriction ring (HP:0009775)2.01694379
106Cervical subluxation (HP:0003308)2.01401416
107Anosmia (HP:0000458)2.00914206
108Intention tremor (HP:0002080)2.00536478
109Knee flexion contracture (HP:0006380)1.99813631
110Mitral valve prolapse (HP:0001634)1.99774052
111Abnormal hair laboratory examination (HP:0003328)1.99516356
112Pili torti (HP:0003777)1.98697224
113Absent eyelashes (HP:0000561)1.98348054
114Increased circulating renin level (HP:0000848)1.98223034
115Hyporeflexia of lower limbs (HP:0002600)1.98101959
116Bell-shaped thorax (HP:0001591)1.97626354
117Abnormality of the fetal cardiovascular system (HP:0010948)1.97574984
118Abnormal umbilical cord blood vessels (HP:0011403)1.97574984
119Single umbilical artery (HP:0001195)1.97574984
120Advanced eruption of teeth (HP:0006288)1.97118305
121Short nail (HP:0001799)1.93165287
122Hypotrichosis (HP:0001006)1.93083862
123Abnormality of the middle phalanges of the toes (HP:0010183)1.92949850
124Dilatation of the ascending aorta (HP:0005111)1.92743948
125Sensory axonal neuropathy (HP:0003390)1.92665218
126Adrenal hypoplasia (HP:0000835)1.92590072
127Steppage gait (HP:0003376)1.92482286
128Nail dystrophy (HP:0008404)1.91812616
129Aplasia cutis congenita (HP:0001057)1.89650384
130Chronic bronchitis (HP:0004469)1.89020574
131Cerebral hemorrhage (HP:0001342)1.88914339
132Overgrowth (HP:0001548)1.88724057
133Ovoid vertebral bodies (HP:0003300)1.87802545
134Abnormality of glycolysis (HP:0004366)1.86798172
135Increased serum pyruvate (HP:0003542)1.86798172
136Deformed tarsal bones (HP:0008119)1.86325370
137Spinal rigidity (HP:0003306)1.85756538
138Ulnar bowing (HP:0003031)1.85270926
139Barrel-shaped chest (HP:0001552)1.85115093
140Abnormality of macular pigmentation (HP:0008002)1.84796167
141Selective tooth agenesis (HP:0001592)1.84535679
142Femoral bowing (HP:0002980)1.83326438
143Megalencephaly (HP:0001355)1.83059472
144Mixed hearing impairment (HP:0000410)1.82125710
145Aortic regurgitation (HP:0001659)1.80977182
146Male infertility (HP:0003251)1.80812464
147Stridor (HP:0010307)1.80775718
148Difficulty running (HP:0009046)1.78749844
149Abnormal tarsal ossification (HP:0008369)1.77653181
150Shallow orbits (HP:0000586)1.77453843
151Abnormality of the calf musculature (HP:0001430)1.76708812
152Generalized tonic-clonic seizures (HP:0002069)1.76458550
153Abnormality of the axillary hair (HP:0100134)1.75882903
154Abnormality of secondary sexual hair (HP:0009888)1.75882903
155Blue sclerae (HP:0000592)1.74888967
156Hallux valgus (HP:0001822)1.74317055
157Abnormality of the distal phalanges of the toes (HP:0010182)1.74153198
158Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.73531818
159Abnormality of femoral epiphyses (HP:0006499)1.73531818
160Lower limb muscle weakness (HP:0007340)1.73105919
161Protuberant abdomen (HP:0001538)1.72640671
162Generalized hypopigmentation (HP:0007513)1.72577235
163Decreased lacrimation (HP:0000633)1.72507894
164Deviation of the hallux (HP:0010051)1.72344279
165Vaginal atresia (HP:0000148)1.70913381
166Abnormal delivery (HP:0001787)1.70043055
167Genital tract atresia (HP:0001827)1.69886114
168Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.69568897
169Severe Myopia (HP:0011003)1.69355243
170Parakeratosis (HP:0001036)1.68786838
171Tibial bowing (HP:0002982)1.68583816
172Methylmalonic acidemia (HP:0002912)1.67875143
173Absent phalangeal crease (HP:0006109)1.67794017
174Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.67509994
175Autoamputation (HP:0001218)1.67158968
176Abnormality of liposaccharide metabolism (HP:0010968)1.67041284
177Abnormality of glycosphingolipid metabolism (HP:0004343)1.67041284
178Abnormality of glycolipid metabolism (HP:0010969)1.67041284
179Lip pit (HP:0100267)1.66538309
180Blue irides (HP:0000635)1.66248114
181Abnormality of the epiphysis of the femoral head (HP:0010574)1.66227193
182Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.65978475
183Hyperextensible skin (HP:0000974)1.65621716
184Genu varum (HP:0002970)1.65242337
185Genu recurvatum (HP:0002816)1.65062162
186Flattened epiphyses (HP:0003071)1.65042008
187Round ear (HP:0100830)1.64634676
188Hypothermia (HP:0002045)1.64550289
189Skin nodule (HP:0200036)1.64472307
190Focal motor seizures (HP:0011153)1.63991853
191Abnormality of the femoral head (HP:0003368)1.63768090
192Leukodystrophy (HP:0002415)1.63676380
193Decreased motor nerve conduction velocity (HP:0003431)1.63645937
194Cerebellar dysplasia (HP:0007033)1.63473108
195Hoarse voice (HP:0001609)1.62338868
196Albinism (HP:0001022)1.62252352
197Focal seizures (HP:0007359)1.61914721
198Delayed gross motor development (HP:0002194)1.61595803
199Muscle fiber inclusion bodies (HP:0100299)1.61460157
200Absent frontal sinuses (HP:0002688)1.61338266

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK394.74006947
2MAPKAPK53.24457504
3OXSR13.16048091
4MUSK3.13534116
5MST1R3.08348959
6EPHB12.87845010
7KSR22.45167036
8WNK42.42794747
9PDGFRA2.42304639
10MAP3K122.27237698
11SCYL22.22031573
12MYLK2.21965854
13PIM22.17786430
14EIF2AK32.09888704
15NTRK12.03780608
16DDR22.03073660
17PHKG21.98650727
18PHKG11.98650727
19TGFBR21.95065769
20AKT31.94501125
21PAK61.91919696
22MAP3K91.88272684
23ARAF1.87533509
24RIPK11.84900550
25STK241.84704438
26NEK11.80868039
27LIMK11.79628209
28CSNK1G31.77395744
29EPHB21.65554596
30KSR11.61590423
31PDK21.58736388
32MAPK151.56342513
33TTN1.54317292
34CSNK1G21.52908940
35PAK31.51451152
36PTK21.50563085
37CSNK1G11.50510345
38EPHA21.47874413
39WNK11.46724842
40PKN11.45364900
41PAK21.40994888
42EEF2K1.40053324
43LATS21.37815207
44ERBB41.36875424
45CAMK2D1.36020297
46BMPR21.34237737
47LMTK21.33287860
48PINK11.32884776
49BCR1.31604898
50MET1.30865488
51TGFBR11.30015654
52DYRK21.29244665
53MARK11.28775470
54SGK2231.28334259
55SGK4941.28334259
56PIK3CG1.27551941
57UHMK11.26924645
58PAK41.26807136
59CAMK2B1.23642188
60EPHA31.21423846
61MAP3K41.21089427
62MAP3K21.20260663
63EIF2AK11.12106752
64CSNK1A1L1.11815423
65SIK11.08963628
66PIK3CA1.08683902
67ERBB31.06318452
68BRAF1.04513199
69TESK11.02378366
70PRKD31.02077433
71CAMK2A1.01977043
72STK38L0.98324596
73CDK190.96635848
74TYRO30.95904865
75MOS0.95451633
76ROCK20.95162903
77CAMK2G0.94838589
78MARK20.92279202
79OBSCN0.92016890
80CASK0.90946085
81HIPK20.90043698
82STK30.89251545
83ICK0.86848689
84TRPM70.85040476
85PDGFRB0.84658051
86NTRK30.83847887
87FGFR20.82499096
88MAPK130.82005192
89ILK0.81451906
90INSRR0.81071742
91WEE10.80661202
92LATS10.79920093
93PBK0.78983262
94RET0.76843940
95FGFR30.75401226
96TAOK30.75360520
97CDK50.74334672
98MAP3K60.74095806
99MST40.73144256
100GRK50.72741118
101MAP2K10.72079332
102CDK60.72038138
103PLK40.71452840
104CAMK1G0.71241641
105EIF2AK20.70532780
106ROCK10.70282310
107AKT20.70129334
108MAPKAPK30.69314821
109PRKCE0.67662225
110CDK140.66873679
111PRKD10.66445923
112PLK20.66245566
113FGR0.65924276
114RAF10.65097571
115NME10.64730326
116STK380.64424996
117ABL20.63238752
118MAP2K70.63085885
119NTRK20.61858708
120STK110.56856252
121FGFR10.56274464
122NEK60.54814915
123MTOR0.54738207
124CDK150.53848222
125PNCK0.53653885
126PKN20.52564023
127PRKG20.51225978
128GRK70.51047673
129MINK10.51041606
130MAP2K40.50768797
131ERN10.50261539
132CDK180.50221438
133TTK0.50025738
134MELK0.49470399
135MAP3K10.47818291
136BRD40.47648130
137CCNB10.47295466
138MAPK70.47212411
139RPS6KA20.46996226
140MAP2K20.46406483
141RPS6KB10.45580342
142FLT30.45168564
143EPHA40.45058567
144PRKG10.45041342
145CDK11A0.44771050
146DMPK0.44733586
147GSK3A0.43944390
148FRK0.42796110
149CDK120.40672656
150JAK10.39006663
151MAP3K130.38170509
152FER0.38122476
153PRKACA0.36375363
154ABL10.35827342
155NEK90.35804965
156DAPK30.34304666
157MAP3K50.32971051
158PDPK10.32772658
159CSNK1A10.31578264

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.64595248
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91182177
3Steroid biosynthesis_Homo sapiens_hsa001002.69623987
4Fatty acid elongation_Homo sapiens_hsa000622.63015047
5Ether lipid metabolism_Homo sapiens_hsa005652.45980842
6Small cell lung cancer_Homo sapiens_hsa052222.35258758
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.29072031
8Olfactory transduction_Homo sapiens_hsa047402.22528907
9Focal adhesion_Homo sapiens_hsa045102.12190479
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.97932114
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.88799319
12Linoleic acid metabolism_Homo sapiens_hsa005911.88465463
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.81232752
14Proteoglycans in cancer_Homo sapiens_hsa052051.75937964
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74182166
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.73204866
17Other glycan degradation_Homo sapiens_hsa005111.71489099
18Serotonergic synapse_Homo sapiens_hsa047261.67581197
19GABAergic synapse_Homo sapiens_hsa047271.66221101
20Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65235656
21Dorso-ventral axis formation_Homo sapiens_hsa043201.64808647
22Renin-angiotensin system_Homo sapiens_hsa046141.63094547
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.61869746
24Synaptic vesicle cycle_Homo sapiens_hsa047211.60911524
25Ovarian steroidogenesis_Homo sapiens_hsa049131.60266609
26Adherens junction_Homo sapiens_hsa045201.59010696
27Sulfur metabolism_Homo sapiens_hsa009201.56280822
28Sphingolipid metabolism_Homo sapiens_hsa006001.49956868
29Histidine metabolism_Homo sapiens_hsa003401.49266677
30Insulin secretion_Homo sapiens_hsa049111.48872823
31Protein export_Homo sapiens_hsa030601.47953924
32Lysosome_Homo sapiens_hsa041421.44931375
33Folate biosynthesis_Homo sapiens_hsa007901.44773410
34Glutamatergic synapse_Homo sapiens_hsa047241.43287618
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.41537018
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41275395
37Amoebiasis_Homo sapiens_hsa051461.39505893
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.39401438
39Oxidative phosphorylation_Homo sapiens_hsa001901.39047394
40TGF-beta signaling pathway_Homo sapiens_hsa043501.38776642
41Circadian entrainment_Homo sapiens_hsa047131.36762156
42Long-term depression_Homo sapiens_hsa047301.34746745
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.33563758
44Taste transduction_Homo sapiens_hsa047421.32534361
45Cocaine addiction_Homo sapiens_hsa050301.30125060
46Bladder cancer_Homo sapiens_hsa052191.28377383
47Dopaminergic synapse_Homo sapiens_hsa047281.27144586
48Vibrio cholerae infection_Homo sapiens_hsa051101.26637604
49Cardiac muscle contraction_Homo sapiens_hsa042601.24557461
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.24533528
51Salivary secretion_Homo sapiens_hsa049701.23343011
52Parkinsons disease_Homo sapiens_hsa050121.21470828
53Hippo signaling pathway_Homo sapiens_hsa043901.21433044
54Gastric acid secretion_Homo sapiens_hsa049711.19885383
55Butanoate metabolism_Homo sapiens_hsa006501.19383873
56PPAR signaling pathway_Homo sapiens_hsa033201.15741190
57Thyroid cancer_Homo sapiens_hsa052161.15727054
58Cholinergic synapse_Homo sapiens_hsa047251.15575996
59p53 signaling pathway_Homo sapiens_hsa041151.13844173
60Morphine addiction_Homo sapiens_hsa050321.11666327
61MicroRNAs in cancer_Homo sapiens_hsa052061.11380756
62Alzheimers disease_Homo sapiens_hsa050101.11175853
63GnRH signaling pathway_Homo sapiens_hsa049121.10744969
64N-Glycan biosynthesis_Homo sapiens_hsa005101.10725346
65Renal cell carcinoma_Homo sapiens_hsa052111.10533598
66Vascular smooth muscle contraction_Homo sapiens_hsa042701.10473078
67Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04125396
68Axon guidance_Homo sapiens_hsa043601.00830649
69Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.99746801
70Collecting duct acid secretion_Homo sapiens_hsa049660.98900930
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98342892
72Melanoma_Homo sapiens_hsa052180.97074371
73Prostate cancer_Homo sapiens_hsa052150.96648074
74Fatty acid metabolism_Homo sapiens_hsa012120.95359218
75Gap junction_Homo sapiens_hsa045400.94126468
76Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.93812612
77Arginine and proline metabolism_Homo sapiens_hsa003300.93744036
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.93594508
79One carbon pool by folate_Homo sapiens_hsa006700.92646100
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92435521
81Mineral absorption_Homo sapiens_hsa049780.91905035
82Amphetamine addiction_Homo sapiens_hsa050310.91484492
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91411930
84Nicotine addiction_Homo sapiens_hsa050330.91382984
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90323334
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.90067308
87Tight junction_Homo sapiens_hsa045300.89448537
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.88448972
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.88267545
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86973623
91Phototransduction_Homo sapiens_hsa047440.86939979
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.86221084
93PI3K-Akt signaling pathway_Homo sapiens_hsa041510.84354715
94Renin secretion_Homo sapiens_hsa049240.83140130
95cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81675252
96Glioma_Homo sapiens_hsa052140.80841450
97Pancreatic secretion_Homo sapiens_hsa049720.80507233
98Protein digestion and absorption_Homo sapiens_hsa049740.80433426
99Galactose metabolism_Homo sapiens_hsa000520.80225108
100Vitamin B6 metabolism_Homo sapiens_hsa007500.79653944
101Arginine biosynthesis_Homo sapiens_hsa002200.78764050
102Fatty acid degradation_Homo sapiens_hsa000710.77802108
103Ras signaling pathway_Homo sapiens_hsa040140.77161265
104Thyroid hormone synthesis_Homo sapiens_hsa049180.76814664
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.76659105
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76551064
107Pancreatic cancer_Homo sapiens_hsa052120.75603715
108Circadian rhythm_Homo sapiens_hsa047100.75455290
109Carbon metabolism_Homo sapiens_hsa012000.74946161
110Oxytocin signaling pathway_Homo sapiens_hsa049210.74462099
111Prion diseases_Homo sapiens_hsa050200.74228123
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72698012
113Pentose phosphate pathway_Homo sapiens_hsa000300.72496428
114Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.72434452
115Inositol phosphate metabolism_Homo sapiens_hsa005620.71914136
116Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71816860
117cAMP signaling pathway_Homo sapiens_hsa040240.71072790
118Pathways in cancer_Homo sapiens_hsa052000.70181275
119Long-term potentiation_Homo sapiens_hsa047200.69867608
120Dilated cardiomyopathy_Homo sapiens_hsa054140.69591503
121Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69156087
122Starch and sucrose metabolism_Homo sapiens_hsa005000.67924065
123Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67769920
124Tyrosine metabolism_Homo sapiens_hsa003500.67508982
125Choline metabolism in cancer_Homo sapiens_hsa052310.65811164
126Chronic myeloid leukemia_Homo sapiens_hsa052200.64541323
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.64185581
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.63488535
129Propanoate metabolism_Homo sapiens_hsa006400.63026542
130Basal cell carcinoma_Homo sapiens_hsa052170.61431719
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.61429791
132Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61391616
133ErbB signaling pathway_Homo sapiens_hsa040120.60598515
134AMPK signaling pathway_Homo sapiens_hsa041520.60355921
135Huntingtons disease_Homo sapiens_hsa050160.59959256
136mTOR signaling pathway_Homo sapiens_hsa041500.59732286
137Complement and coagulation cascades_Homo sapiens_hsa046100.59684161
138Estrogen signaling pathway_Homo sapiens_hsa049150.58766548
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57990795
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57825730
141Selenocompound metabolism_Homo sapiens_hsa004500.57090041
142Melanogenesis_Homo sapiens_hsa049160.56262655
143Arachidonic acid metabolism_Homo sapiens_hsa005900.55379761
144Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54674263
145Primary bile acid biosynthesis_Homo sapiens_hsa001200.54080834
146Glucagon signaling pathway_Homo sapiens_hsa049220.53625246
147Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52188494
148Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51997919
149Pyruvate metabolism_Homo sapiens_hsa006200.51472067
150Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51307520
151Glutathione metabolism_Homo sapiens_hsa004800.50999867
152Endometrial cancer_Homo sapiens_hsa052130.50892428
153Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50601969
154ECM-receptor interaction_Homo sapiens_hsa045120.49668170
155Fatty acid biosynthesis_Homo sapiens_hsa000610.49555533
156Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47937537
157Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47886932
158Calcium signaling pathway_Homo sapiens_hsa040200.47069148
159Biosynthesis of amino acids_Homo sapiens_hsa012300.46830399
160Insulin resistance_Homo sapiens_hsa049310.44959445
161Adipocytokine signaling pathway_Homo sapiens_hsa049200.44868607
162Vitamin digestion and absorption_Homo sapiens_hsa049770.44648457
163Hedgehog signaling pathway_Homo sapiens_hsa043400.43121999
164Endocytosis_Homo sapiens_hsa041440.41927863
165Bile secretion_Homo sapiens_hsa049760.41737374
166Nitrogen metabolism_Homo sapiens_hsa009100.40103728
167Type II diabetes mellitus_Homo sapiens_hsa049300.38408429

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