TMEM119

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)8.12575978
2regulation of chemokine secretion (GO:0090196)7.74285279
3adhesion of symbiont to host cell (GO:0044650)6.70379842
4virion attachment to host cell (GO:0019062)6.70379842
5keratan sulfate catabolic process (GO:0042340)6.66503901
6negative regulation of granulocyte differentiation (GO:0030853)6.63411702
7cell migration involved in heart development (GO:0060973)6.14264741
8G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)5.98971352
9sequestering of extracellular ligand from receptor (GO:0035581)5.96813699
10regulation of interferon-beta biosynthetic process (GO:0045357)5.95709965
11macrophage activation involved in immune response (GO:0002281)5.86760606
12adhesion of symbiont to host (GO:0044406)5.56335237
13chondroitin sulfate catabolic process (GO:0030207)5.11537100
14blood vessel maturation (GO:0001955)5.07317989
15modulation by symbiont of host immune response (GO:0052553)5.06480085
16positive regulation by symbiont of host defense response (GO:0052509)5.06480085
17modulation by symbiont of host defense response (GO:0052031)5.06480085
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.06480085
19modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.06480085
20positive regulation by organism of defense response of other organism involved in symbiotic interact5.06480085
21negative regulation of leukocyte chemotaxis (GO:0002689)5.00555451
22bone trabecula formation (GO:0060346)5.00402330
23monocyte differentiation (GO:0030224)4.91480810
24extracellular matrix assembly (GO:0085029)4.81828663
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.79042864
26tooth mineralization (GO:0034505)4.73733954
27oligosaccharide catabolic process (GO:0009313)4.66022087
28pathway-restricted SMAD protein phosphorylation (GO:0060389)4.62615564
29hyaluronan catabolic process (GO:0030214)4.51567493
30macrophage activation (GO:0042116)4.47638320
31collagen metabolic process (GO:0032963)4.43608598
32germ cell migration (GO:0008354)4.39893592
33macrophage differentiation (GO:0030225)4.38671914
34collagen catabolic process (GO:0030574)4.34235373
35type B pancreatic cell proliferation (GO:0044342)4.29233604
36skin morphogenesis (GO:0043589)4.29177934
37kidney mesenchyme development (GO:0072074)4.27886964
38metanephric mesenchyme development (GO:0072075)4.25942203
39G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.25187091
40mesenchymal-epithelial cell signaling (GO:0060638)4.23292181
41cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.23014215
42multicellular organismal macromolecule metabolic process (GO:0044259)4.15294139
43multicellular organismal catabolic process (GO:0044243)4.07323329
44glycosphingolipid catabolic process (GO:0046479)4.07106403
45negative regulation of tissue remodeling (GO:0034104)4.05851082
46regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.05006866
47cellular response to vitamin (GO:0071295)3.99598520
48mannose metabolic process (GO:0006013)3.96689893
49multicellular organismal metabolic process (GO:0044236)3.95467682
50glial cell migration (GO:0008347)3.90879488
51dermatan sulfate biosynthetic process (GO:0030208)3.90672396
52dermatan sulfate metabolic process (GO:0030205)3.89633495
53purinergic nucleotide receptor signaling pathway (GO:0035590)3.87112930
54cell-cell junction maintenance (GO:0045217)3.84730955
55extracellular regulation of signal transduction (GO:1900115)3.84602602
56extracellular negative regulation of signal transduction (GO:1900116)3.84602602
57chondrocyte proliferation (GO:0035988)3.81360799
58ruffle organization (GO:0031529)3.75316835
59positive regulation of SMAD protein import into nucleus (GO:0060391)3.69432077
60extracellular matrix disassembly (GO:0022617)3.66074234
61I-kappaB phosphorylation (GO:0007252)3.65914492
62regulation of extracellular matrix disassembly (GO:0010715)3.64541830
63vascular endothelial growth factor signaling pathway (GO:0038084)3.62232890
64regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62194133
65glycolipid catabolic process (GO:0019377)3.59953679
66negative regulation of smooth muscle cell migration (GO:0014912)3.59674776
67regulation of chemokine-mediated signaling pathway (GO:0070099)3.56462618
68outer ear morphogenesis (GO:0042473)3.56260398
69negative regulation of bone resorption (GO:0045779)3.54035074
70regulation of mononuclear cell migration (GO:0071675)3.53017689
71glomerular basement membrane development (GO:0032836)3.48234336
72cell proliferation involved in metanephros development (GO:0072203)3.45362327
73regulation of monocyte differentiation (GO:0045655)3.42370473
74stress fiber assembly (GO:0043149)3.37290837
75barbed-end actin filament capping (GO:0051016)3.34501063
76positive regulation of interferon-alpha production (GO:0032727)3.34074973
77regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.33484521
78smooth muscle tissue development (GO:0048745)3.32866512
79regulation of SMAD protein import into nucleus (GO:0060390)3.32532300
80regulation of actin cytoskeleton reorganization (GO:2000249)3.29025060
81response to cholesterol (GO:0070723)3.27185840
82purinergic receptor signaling pathway (GO:0035587)3.26403230
83response to laminar fluid shear stress (GO:0034616)3.26061448
84positive regulation of B cell differentiation (GO:0045579)3.24009844
85negative regulation of interleukin-6 production (GO:0032715)3.23897111
86axon extension involved in axon guidance (GO:0048846)3.23161546
87neuron projection extension involved in neuron projection guidance (GO:1902284)3.23161546
88middle ear morphogenesis (GO:0042474)3.22791801
89substrate-dependent cell migration (GO:0006929)3.21219470
90regulation of monocyte chemotaxis (GO:0090025)3.19083287
91cortical actin cytoskeleton organization (GO:0030866)3.18592120
92collagen fibril organization (GO:0030199)3.18275156
93regulation of B cell receptor signaling pathway (GO:0050855)3.17386958
94negative regulation of bone remodeling (GO:0046851)3.16599090
95adenosine receptor signaling pathway (GO:0001973)3.16253114
96receptor catabolic process (GO:0032801)3.15829354
97apoptotic cell clearance (GO:0043277)3.15502587
98ceramide catabolic process (GO:0046514)3.15033265
99sodium-independent organic anion transport (GO:0043252)3.14914078
100cellular response to amino acid stimulus (GO:0071230)3.13993280
101keratan sulfate metabolic process (GO:0042339)3.12383037
102response to host (GO:0075136)3.11951104
103response to host defenses (GO:0052200)3.11951104
104response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.11951104
105extracellular matrix organization (GO:0030198)3.11413762
106positive regulation of endothelial cell apoptotic process (GO:2000353)3.11324914
107peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.11249837
108extracellular structure organization (GO:0043062)3.10277686
109cellular response to vitamin D (GO:0071305)3.07928277
110regulation of interferon-alpha production (GO:0032647)3.07533000
111lysosome organization (GO:0007040)3.05544074
112lytic vacuole organization (GO:0080171)3.05544074
113cellular extravasation (GO:0045123)3.04287710
114regulation of granulocyte differentiation (GO:0030852)3.02397054
115basement membrane organization (GO:0071711)3.01563352
116mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.01538428
117protein heterotrimerization (GO:0070208)3.00271312
118phagocytosis, engulfment (GO:0006911)2.98853130
119heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.96814296
120cell junction maintenance (GO:0034331)2.94964892
121negative regulation of multicellular organism growth (GO:0040015)2.94669638
122negative regulation of erythrocyte differentiation (GO:0045647)2.91854947
123extracellular fibril organization (GO:0043206)2.91749979
124negative regulation of BMP signaling pathway (GO:0030514)2.90786499
125positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.90535914
126response to fluid shear stress (GO:0034405)2.89481718
127regulation of bone resorption (GO:0045124)2.88762742
128response to host immune response (GO:0052572)2.87378623
129response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.87378623
130regulation of smooth muscle cell migration (GO:0014910)2.86862123
131negative regulation of nitric oxide biosynthetic process (GO:0045019)2.83554961
132cortical cytoskeleton organization (GO:0030865)2.83400796
133negative regulation of macrophage differentiation (GO:0045650)2.83291470
134negative regulation of chondrocyte differentiation (GO:0032331)2.80404698
135positive regulation of chemokine production (GO:0032722)2.79841039
136regulation of macrophage chemotaxis (GO:0010758)2.77896358
137cyclooxygenase pathway (GO:0019371)2.75839872
138cellular response to interleukin-6 (GO:0071354)2.73741645
139venous blood vessel morphogenesis (GO:0048845)2.73141819
140regulation of bone remodeling (GO:0046850)2.72106506
141phagocytosis, recognition (GO:0006910)2.71949797
142adaptation of signaling pathway (GO:0023058)2.69732704
143cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.68943278
144negative regulation of nitric-oxide synthase activity (GO:0051001)2.68881394
145response to sterol (GO:0036314)2.68254346
146fibril organization (GO:0097435)2.68196615
147regulation of ARF GTPase activity (GO:0032312)2.67333869
148vagina development (GO:0060068)2.66556353
149regulation of collagen metabolic process (GO:0010712)2.66309537
150negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.66067412
151embryonic cranial skeleton morphogenesis (GO:0048701)2.65929380
152regulation of erythrocyte differentiation (GO:0045646)2.65747581
153positive regulation of calcium ion import (GO:0090280)2.65546931
154positive regulation of fatty acid beta-oxidation (GO:0032000)2.64464828
155negative regulation of fatty acid transport (GO:2000192)2.64452637
156endodermal cell differentiation (GO:0035987)2.64253573
157myeloid cell activation involved in immune response (GO:0002275)2.63477225
158negative regulation of systemic arterial blood pressure (GO:0003085)2.62906350
159regulation of integrin-mediated signaling pathway (GO:2001044)2.62696811
160positive regulation of erythrocyte differentiation (GO:0045648)2.62315555
161endocardial cushion development (GO:0003197)2.62011117
162chondrocyte development (GO:0002063)2.58651787
163positive regulation of axon extension (GO:0045773)2.55380868
164regulation of phospholipase A2 activity (GO:0032429)2.54585011
165positive regulation of smooth muscle cell migration (GO:0014911)2.52556818
166artery morphogenesis (GO:0048844)2.52113214
167positive regulation of fibroblast migration (GO:0010763)2.51791018
168negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.51599384
169regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.50980101
170cell proliferation involved in kidney development (GO:0072111)2.48655564
171chondroitin sulfate biosynthetic process (GO:0030206)2.47734818
172positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.47123644
173response to magnesium ion (GO:0032026)2.45283965
174regulation of axon extension involved in axon guidance (GO:0048841)2.44714901
175positive regulation of mesenchymal cell proliferation (GO:0002053)2.44247546
176negative regulation of leukocyte migration (GO:0002686)2.42105150
177positive regulation of extracellular matrix organization (GO:1903055)2.41244491
178cellular response to nutrient (GO:0031670)2.40955512
179regulation of plasminogen activation (GO:0010755)2.40485150
180substrate adhesion-dependent cell spreading (GO:0034446)2.39862926
181negative regulation of axon extension involved in axon guidance (GO:0048843)2.35913533
182positive regulation of chemokine secretion (GO:0090197)10.2111384

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.15156772
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.95362611
3IRF8_27001747_Chip-Seq_BMDM_Mouse3.48804438
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.42038144
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.27475313
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.06867168
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05515486
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.83613175
9SCL_19346495_ChIP-Seq_HPC-7_Human2.82434514
10EED_16625203_ChIP-ChIP_MESCs_Mouse2.62550788
11SPI1_23127762_ChIP-Seq_K562_Human2.37381827
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.32596266
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.31904700
14VDR_21846776_ChIP-Seq_THP-1_Human2.24876512
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.23026928
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.22008795
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21312437
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17825724
19* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.15487626
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.12718909
21VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.12398888
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.05057976
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04316419
24VDR_24763502_ChIP-Seq_THP-1_Human2.02928844
25STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.02583964
26* TCF7_22412390_ChIP-Seq_EML_Mouse2.01254574
27TRIM28_21343339_ChIP-Seq_HEK293_Human2.00489016
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98820314
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96463045
30CLOCK_20551151_ChIP-Seq_293T_Human1.95700866
31WT1_19549856_ChIP-ChIP_CCG9911_Human1.92959627
32* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.91000481
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87070246
34NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.85815131
35RUNX_20019798_ChIP-Seq_JUKART_Human1.85150133
36MYC_22102868_ChIP-Seq_BL_Human1.83659621
37IRF8_22096565_ChIP-ChIP_GC-B_Human1.81532601
38SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.79477606
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.78696638
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.76307258
41KDM2B_26808549_Chip-Seq_DND41_Human1.75857384
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73396655
43EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73199978
44RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73199978
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.71582873
46EP300_21415370_ChIP-Seq_HL-1_Mouse1.71064952
47LXR_22292898_ChIP-Seq_THP-1_Human1.69928936
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.68868123
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.68868123
50NFIB_24661679_ChIP-Seq_LUNG_Mouse1.67930031
51JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67501750
52MYB_21317192_ChIP-Seq_ERMYB_Mouse1.66909532
53VDR_24787735_ChIP-Seq_THP-1_Human1.61173500
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.60359223
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59975073
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57397627
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.56596154
58SMC3_22415368_ChIP-Seq_MEFs_Mouse1.56592826
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.54278832
60SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53747185
61KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.53272506
62KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.53272506
63KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.53272506
64SA1_22415368_ChIP-Seq_MEFs_Mouse1.52266466
65TP53_20018659_ChIP-ChIP_R1E_Mouse1.50626123
66KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49430166
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47842866
68Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46728535
69* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.45897426
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.43684732
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42357318
72TP53_18474530_ChIP-ChIP_U2OS_Human1.41976788
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41508491
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40764707
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.39593446
76SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38758425
77GATA2_21666600_ChIP-Seq_HMVEC_Human1.38435754
78CJUN_26792858_Chip-Seq_BT549_Human1.36770049
79MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36087140
80* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.34194941
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33534539
82DROSHA_22980978_ChIP-Seq_HELA_Human1.32656629
83MAF_26560356_Chip-Seq_TH1_Human1.31695030
84BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31273947
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30889694
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.30495343
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.29726978
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27854423
89IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26459325
90KDM2B_26808549_Chip-Seq_K562_Human1.25377751
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25229681
92ZFP281_18757296_ChIP-ChIP_E14_Mouse1.24121408
93* SPI1_23547873_ChIP-Seq_NB4_Human1.23032979
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22761051
95JARID2_20064375_ChIP-Seq_MESCs_Mouse1.22497824
96RNF2_27304074_Chip-Seq_ESCs_Mouse1.21321236
97CDX2_20551321_ChIP-Seq_CACO-2_Human1.20803035
98TP53_22127205_ChIP-Seq_IMR90_Human1.19793052
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.19690359
100RAD21_21589869_ChIP-Seq_MESCs_Mouse1.17897849
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.17751191
102TP53_23651856_ChIP-Seq_MEFs_Mouse1.17610467
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.16848377
104* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16721983
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16268639
106FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.15657414
107GATA1_19941826_ChIP-Seq_K562_Human1.15326338
108P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13843585
109UTX_26944678_Chip-Seq_JUKART_Human1.13669113
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.13129455
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12245324
112CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11861819
113PU_27001747_Chip-Seq_BMDM_Mouse1.09028530
114FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07602363
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.07499044
116PIAS1_25552417_ChIP-Seq_VCAP_Human1.07092754
117* RUNX1_22412390_ChIP-Seq_EML_Mouse1.05739224
118STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05240957
119GATA2_19941826_ChIP-Seq_K562_Human1.05028398
120PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04427742
121BRD4_25478319_ChIP-Seq_HGPS_Human1.03849985
122KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03247689
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02267511
124PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00583406
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00024945
126TBX20_22080862_ChIP-Seq_HEART_Mouse0.98406891
127TBX20_22328084_ChIP-Seq_HEART_Mouse0.98406891
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98133723
129* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97998246
130SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97517154
131* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97472632
132MYB_26560356_Chip-Seq_TH2_Human0.96037001
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.94532903
134TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.94391736
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94267048
136* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94143409
137GATA1_22025678_ChIP-Seq_K562_Human0.93918892
138SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93651508
139PPAR_26484153_Chip-Seq_NCI-H1993_Human0.93448203
140UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.92832446
141RING1B_27294783_Chip-Seq_ESCs_Mouse0.91612264
142FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90548883
143TP53_16413492_ChIP-PET_HCT116_Human0.87988875
144GBX2_23144817_ChIP-Seq_PC3_Human0.87607215
145* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85905266
146DNAJC2_21179169_ChIP-ChIP_NT2_Human0.84904011
147ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84280312
148ZFP57_27257070_Chip-Seq_ESCs_Mouse0.84081240
149CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83484639
150PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.82258380
151ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.80160233
152NR3C1_23031785_ChIP-Seq_PC12_Mouse0.78349854
153SOX2_20726797_ChIP-Seq_SW620_Human0.78143300
154SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76999280
155TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76437359
156* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75704076
157MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.75592438
158PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75285752
159EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.75076759
160AHR_22903824_ChIP-Seq_MCF-7_Human0.73566074

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.93295097
2MP0003191_abnormal_cellular_cholesterol4.32803512
3MP0006082_CNS_inflammation4.16898201
4MP0005058_abnormal_lysosome_morphology3.61672854
5MP0003172_abnormal_lysosome_physiology3.17537273
6MP0003279_aneurysm3.09571758
7MP0005503_abnormal_tendon_morphology2.67561089
8MP0001542_abnormal_bone_strength2.58541477
9MP0003303_peritoneal_inflammation2.45736439
10MP0008004_abnormal_stomach_pH2.36826867
11MP0003705_abnormal_hypodermis_morpholog2.25410895
12MP0003566_abnormal_cell_adhesion2.15555758
13MP0003075_altered_response_to2.12023837
14MP0005275_abnormal_skin_tensile2.10668488
15MP0005464_abnormal_platelet_physiology2.08514887
16MP0004185_abnormal_adipocyte_glucose2.01042426
17MP0003300_gastrointestinal_ulcer2.00281397
18MP0009384_cardiac_valve_regurgitation1.95684069
19MP0001533_abnormal_skeleton_physiology1.93770460
20MP0006054_spinal_hemorrhage1.93731848
21MP0005671_abnormal_response_to1.92881571
22MP0005023_abnormal_wound_healing1.87670939
23MP0000343_altered_response_to1.85570270
24MP0000767_abnormal_smooth_muscle1.85042598
25MP0001243_abnormal_dermal_layer1.83072901
26MP0001958_emphysema1.79009932
27MP0003045_fibrosis1.75209437
28MP0002998_abnormal_bone_remodeling1.73368905
29MP0001915_intracranial_hemorrhage1.72130317
30MP0004883_abnormal_blood_vessel1.68387164
31MP0009278_abnormal_bone_marrow1.67470280
32MP0009840_abnormal_foam_cell1.64907668
33MP0003690_abnormal_glial_cell1.63888380
34MP0000751_myopathy1.63688657
35MP0002928_abnormal_bile_duct1.63119118
36MP0009053_abnormal_anal_canal1.61338447
37MP0002419_abnormal_innate_immunity1.60352144
38MP0001835_abnormal_antigen_presentation1.59767565
39MP0001851_eye_inflammation1.52079839
40MP0005167_abnormal_blood-brain_barrier1.51473598
41MP0005508_abnormal_skeleton_morphology1.51218961
42MP0003252_abnormal_bile_duct1.50219898
43MP0000465_gastrointestinal_hemorrhage1.49935521
44MP0009250_abnormal_appendicular_skeleto1.45453436
45MP0008007_abnormal_cellular_replicative1.45450320
46MP0010368_abnormal_lymphatic_system1.44532314
47MP0002396_abnormal_hematopoietic_system1.44042059
48MP0004272_abnormal_basement_membrane1.42223554
49MP0005390_skeleton_phenotype1.41062980
50MP0005670_abnormal_white_adipose1.38072973
51MP0003724_increased_susceptibility_to1.37449413
52MP0010386_abnormal_urinary_bladder1.37330130
53MP0003091_abnormal_cell_migration1.35965438
54MP0005166_decreased_susceptibility_to1.29421052
55MP0004858_abnormal_nervous_system1.26462379
56MP0002452_abnormal_antigen_presenting1.25658010
57MP0002896_abnormal_bone_mineralization1.24476288
58MP0000013_abnormal_adipose_tissue1.23758932
59MP0000604_amyloidosis1.21664596
60MP0005666_abnormal_adipose_tissue1.17452224
61MP0000249_abnormal_blood_vessel1.16856140
62MP0003183_abnormal_peptide_metabolism1.16773133
63MP0003436_decreased_susceptibility_to1.09414326
64MP0005257_abnormal_intraocular_pressure1.09062531
65MP0000163_abnormal_cartilage_morphology1.08631760
66MP0003283_abnormal_digestive_organ1.06576076
67MP0002090_abnormal_vision1.02185777
68MP0004808_abnormal_hematopoietic_stem1.01193542
69MP0002723_abnormal_immune_serum0.99787807
70MP0003385_abnormal_body_wall0.99088253
71MP0003448_altered_tumor_morphology0.98740273
72MP0005397_hematopoietic_system_phenotyp0.98623629
73MP0001545_abnormal_hematopoietic_system0.98623629
74MP0005164_abnormal_response_to0.96329410
75MP0003950_abnormal_plasma_membrane0.95476808
76MP0002108_abnormal_muscle_morphology0.94720832
77MP0005623_abnormal_meninges_morphology0.94174376
78MP0000733_abnormal_muscle_development0.94101053
79MP0005000_abnormal_immune_tolerance0.94059934
80MP0002115_abnormal_skeleton_extremities0.93815426
81MP0003828_pulmonary_edema0.93769491
82MP0001299_abnormal_eye_distance/0.93258541
83MP0009333_abnormal_splenocyte_physiolog0.93060784
84MP0000049_abnormal_middle_ear0.92811101
85MP0001819_abnormal_immune_cell0.91349938
86MP0010030_abnormal_orbit_morphology0.91108859
87MP0005375_adipose_tissue_phenotype0.89758499
88MP0002254_reproductive_system_inflammat0.89696900
89MP0005165_increased_susceptibility_to0.88901410
90MP0003795_abnormal_bone_structure0.88542807
91MP0001800_abnormal_humoral_immune0.88262720
92MP0001614_abnormal_blood_vessel0.86984930
93MP0002933_joint_inflammation0.86830870
94MP0002420_abnormal_adaptive_immunity0.86811190
95MP0005171_absent_coat_pigmentation0.86689206
96MP0000538_abnormal_urinary_bladder0.85183355
97MP0008469_abnormal_protein_level0.84202028
98MP0002148_abnormal_hypersensitivity_rea0.83919979
99MP0002133_abnormal_respiratory_system0.83864806
100MP0005388_respiratory_system_phenotype0.83864806
101MP0002113_abnormal_skeleton_development0.81483789
102MP0002925_abnormal_cardiovascular_devel0.79955515
103MP0001879_abnormal_lymphatic_vessel0.79417266
104MP0000428_abnormal_craniofacial_morphol0.78648371
105MP0004484_altered_response_of0.77899102
106MP0003329_amyloid_beta_deposits0.77669757
107MP0008873_increased_physiological_sensi0.75947075
108MP0004510_myositis0.74617474
109MP0005076_abnormal_cell_differentiation0.74294519
110MP0000689_abnormal_spleen_morphology0.73385270
111MP0000681_abnormal_thyroid_gland0.73261591
112MP0001845_abnormal_inflammatory_respons0.72904682
113MP0004134_abnormal_chest_morphology0.72316617
114MP0009672_abnormal_birth_weight0.71179533
115MP0002128_abnormal_blood_circulation0.71131011
116MP0002282_abnormal_trachea_morphology0.71006190
117MP0000534_abnormal_ureter_morphology0.70620169
118MP0000747_muscle_weakness0.70058093
119MP0002060_abnormal_skin_morphology0.69991068
120MP0002932_abnormal_joint_morphology0.69574013
121MP0002295_abnormal_pulmonary_circulatio0.68835076
122MP0005197_abnormal_uvea_morphology0.67808268
123MP0001849_ear_inflammation0.67564624
124MP0001175_abnormal_lung_morphology0.67311152
125MP0005595_abnormal_vascular_smooth0.66454195
126MP0003942_abnormal_urinary_system0.66337332
127MP0000759_abnormal_skeletal_muscle0.66185485
128MP0009780_abnormal_chondrocyte_physiolo0.66029806
129MP0000230_abnormal_systemic_arterial0.65731006
130MP0002135_abnormal_kidney_morphology0.65478454
131MP0002168_other_aberrant_phenotype0.64904266
132MP0001348_abnormal_lacrimal_gland0.64235910
133MP0000685_abnormal_immune_system0.63405676
134MP0000432_abnormal_head_morphology0.61243680
135MP0009764_decreased_sensitivity_to0.57359902
136MP0000750_abnormal_muscle_regeneration0.55607364
137MP0003941_abnormal_skin_development0.55203143
138MP0002116_abnormal_craniofacial_bone0.54732130
139MP0001270_distended_abdomen0.54679335
140MP0002109_abnormal_limb_morphology0.50730884
141MP0001756_abnormal_urination0.50261238
142MP0003115_abnormal_respiratory_system0.50029942
143MP0000462_abnormal_digestive_system0.47470706
144MP0005369_muscle_phenotype0.46181557
145MP0002249_abnormal_larynx_morphology0.45909713

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.72460937
2Glomerulonephritis (HP:0000099)7.32930759
3Cerebral aneurysm (HP:0004944)6.39865040
4Arterial tortuosity (HP:0005116)5.98510905
5Abnormality of glycolipid metabolism (HP:0010969)5.76176354
6Abnormality of liposaccharide metabolism (HP:0010968)5.76176354
7Abnormality of glycosphingolipid metabolism (HP:0004343)5.76176354
8Complement deficiency (HP:0004431)5.71334887
9Vascular tortuosity (HP:0004948)5.68926543
10Follicular hyperkeratosis (HP:0007502)5.60588721
11Aortic aneurysm (HP:0004942)5.32410644
12Type 1 muscle fiber predominance (HP:0003803)5.08131261
13Aortic dissection (HP:0002647)4.80380639
14Mutism (HP:0002300)4.34841843
15Abnormality of complement system (HP:0005339)4.31376081
16Protrusio acetabuli (HP:0003179)4.28567290
17Hematochezia (HP:0002573)4.12847400
18Increased cerebral lipofuscin (HP:0011813)3.85614579
19Retinal atrophy (HP:0001105)3.82331836
20Disproportionate tall stature (HP:0001519)3.80450320
21Premature rupture of membranes (HP:0001788)3.76703111
22Spinal rigidity (HP:0003306)3.76539536
23Abnormality of dentin (HP:0010299)3.76105198
24Nephritis (HP:0000123)3.66789710
25Fragile skin (HP:0001030)3.64382761
26Dysostosis multiplex (HP:0000943)3.63688849
27Increased neuronal autofluorescent lipopigment (HP:0002074)3.61995719
28Mitral valve prolapse (HP:0001634)3.60043021
29Urethral obstruction (HP:0000796)3.59390155
30Neonatal short-limb short stature (HP:0008921)3.52875232
31Striae distensae (HP:0001065)3.50945718
32Soft skin (HP:0000977)3.27149307
33Orthostatic hypotension (HP:0001278)3.26993290
34Spondylolisthesis (HP:0003302)3.14661837
35Shallow orbits (HP:0000586)3.11363452
36Aortic regurgitation (HP:0001659)3.08575532
37Increased variability in muscle fiber diameter (HP:0003557)3.05210147
38Hypoventilation (HP:0002791)3.02702348
39Aortic valve stenosis (HP:0001650)2.92511454
40Dilatation of the ascending aorta (HP:0005111)2.87836296
41Mildly elevated creatine phosphokinase (HP:0008180)2.83036601
42Wrist flexion contracture (HP:0001239)2.80904359
43Arnold-Chiari malformation (HP:0002308)2.77585580
44Disinhibition (HP:0000734)2.70610327
45Axonal loss (HP:0003447)2.69851614
46Mucopolysacchariduria (HP:0008155)2.69436085
47Urinary glycosaminoglycan excretion (HP:0003541)2.69436085
48Bladder diverticulum (HP:0000015)2.60216155
49Mild short stature (HP:0003502)2.60066056
50Neuronal loss in central nervous system (HP:0002529)2.52438753
51Camptodactyly of toe (HP:0001836)2.50661662
52Wide anterior fontanel (HP:0000260)2.50555851
53Redundant skin (HP:0001582)2.49560839
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49232209
55Abnormality of polysaccharide metabolism (HP:0011012)2.49232209
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49232209
57Overgrowth (HP:0001548)2.47158198
58Mitral regurgitation (HP:0001653)2.46796740
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.42787482
60Abnormality of skeletal muscle fiber size (HP:0012084)2.42162178
61Recurrent bacterial skin infections (HP:0005406)2.41854711
62Blue sclerae (HP:0000592)2.39687594
63Recurrent abscess formation (HP:0002722)2.39117630
64Aneurysm (HP:0002617)2.39056133
65Elbow flexion contracture (HP:0002987)2.38897049
66Colitis (HP:0002583)2.33145696
67Abnormal delivery (HP:0001787)2.32416384
68Polygenic inheritance (HP:0010982)2.31926700
69Joint stiffness (HP:0001387)2.29644290
70Cardiomegaly (HP:0001640)2.29618312
71Nonimmune hydrops fetalis (HP:0001790)2.29234139
72Generalized amyotrophy (HP:0003700)2.28775218
73Thin bony cortex (HP:0002753)2.28630985
74Delayed closure of the anterior fontanelle (HP:0001476)2.26680211
75Emphysema (HP:0002097)2.26297061
76Chronic diarrhea (HP:0002028)2.24787980
77Coronal craniosynostosis (HP:0004440)2.23894345
78Agnosia (HP:0010524)2.22374649
79Progressive neurologic deterioration (HP:0002344)2.20424218
80Bicuspid aortic valve (HP:0001647)2.18446994
81Peritonitis (HP:0002586)2.15843411
82Round ear (HP:0100830)2.15697205
83Flat cornea (HP:0007720)2.15469703
84Mesomelia (HP:0003027)2.15034700
85Increased corneal curvature (HP:0100692)2.13742722
86Keratoconus (HP:0000563)2.13742722
87Eczematoid dermatitis (HP:0000976)2.12796884
88Gingival overgrowth (HP:0000212)2.10928938
89Increased connective tissue (HP:0009025)2.10769003
90Ulnar deviation of the wrist (HP:0003049)2.09416398
91Delayed cranial suture closure (HP:0000270)2.09251211
92Ectopia lentis (HP:0001083)2.08572188
93Pulmonary artery stenosis (HP:0004415)2.05307024
94Broad metatarsal (HP:0001783)2.04875407
95Long toe (HP:0010511)2.04835272
96Partial duplication of the phalanx of hand (HP:0009999)2.03711872
97Amyloidosis (HP:0011034)2.03287159
98Narrow nasal bridge (HP:0000446)2.03270421
99Osteoarthritis (HP:0002758)2.00908227
100Atrophic scars (HP:0001075)1.98810584
101Protruding ear (HP:0000411)1.97380768
102Pathologic fracture (HP:0002756)1.96823191
103Flared iliac wings (HP:0002869)1.96476252
104Mitral stenosis (HP:0001718)1.95528126
105Persistence of primary teeth (HP:0006335)1.94748850
106Vertebral compression fractures (HP:0002953)1.94720963
107Abnormality of skull ossification (HP:0002703)1.94301657
108Genu recurvatum (HP:0002816)1.92125739
109Osteolytic defects of the hand bones (HP:0009699)1.91878336
110Osteolytic defects of the phalanges of the hand (HP:0009771)1.91878336
111Infantile muscular hypotonia (HP:0008947)1.89636049
112Deviation of the hallux (HP:0010051)1.89434500
113Femoral bowing (HP:0002980)1.89366026
114Breech presentation (HP:0001623)1.89127764
115Hallux valgus (HP:0001822)1.87790062
116Hypoplasia of the odontoid process (HP:0003311)1.85521823
117Inguinal hernia (HP:0000023)1.85098973
118Achilles tendon contracture (HP:0001771)1.85058283
119Asymmetric septal hypertrophy (HP:0001670)1.84441231
120Limb-girdle muscle weakness (HP:0003325)1.84036867
121Joint laxity (HP:0001388)1.81614628
122Ankle contracture (HP:0006466)1.80385431
123Joint contractures involving the joints of the feet (HP:0100492)1.80177124
124Flexion contracture of toe (HP:0005830)1.80177124
125Partial duplication of thumb phalanx (HP:0009944)1.79768156
126Cervical subluxation (HP:0003308)1.79726960
127Wormian bones (HP:0002645)1.77298893
128Spontaneous hematomas (HP:0007420)1.75451384
129Broad ribs (HP:0000885)1.73119475
130Hepatosplenomegaly (HP:0001433)1.72950987
131Exotropia (HP:0000577)1.72774346
132Upper motor neuron abnormality (HP:0002127)1.72723498
133Scapular winging (HP:0003691)1.71681089
134Lower limb asymmetry (HP:0100559)1.71314594
135Ovoid vertebral bodies (HP:0003300)1.71040629
136Bowel diverticulosis (HP:0005222)1.70948577
137Abnormality of the peritoneum (HP:0002585)1.67463411
138Inflammation of the large intestine (HP:0002037)1.66081560
139Hyperextensible skin (HP:0000974)1.65379410
140Cellulitis (HP:0100658)1.62927847
141Biconcave vertebral bodies (HP:0004586)1.62155997
142Abnormality of the Achilles tendon (HP:0005109)1.62049159
143Vacuolated lymphocytes (HP:0001922)1.60898567
144Slender build (HP:0001533)1.60738874
145Thoracic kyphosis (HP:0002942)1.60457991
146Impaired platelet aggregation (HP:0003540)1.59914981
147Abnormal platelet function (HP:0011869)1.59914981
148Abnormality of the acetabulum (HP:0003170)1.59552461
149Gastrointestinal inflammation (HP:0004386)1.59467922
150Erectile abnormalities (HP:0100639)1.56411218
151Rectal fistula (HP:0100590)1.55675435

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.72809353
2MAPK155.22446637
3MYLK4.06493788
4CSF1R3.83956800
5TSSK63.50921686
6PAK42.98665503
7GRK72.97431574
8PKN22.37549190
9ERN12.31541081
10PRKD22.20876085
11CDC42BPA2.18367769
12EEF2K2.15134808
13CAMK1D2.08437481
14TRIB32.03537465
15TYK21.91683231
16LIMK11.78942830
17CLK11.77578334
18ABL21.76985400
19TESK11.71386157
20ADRBK11.67709910
21PAK21.65772291
22CAMK1G1.63240275
23GRK11.51252718
24PDK21.48633676
25STK101.42733361
26NTRK11.42124778
27MAPK121.40221478
28AKT31.35906302
29MAP3K101.32008709
30MOS1.31109246
31TBK11.29553206
32PTK21.28096451
33PTK61.27613936
34VRK11.24968614
35JAK31.22567337
36STK381.20025377
37DDR21.16958814
38CAMKK21.14648165
39EPHB11.14559132
40JAK11.13002919
41RIPK41.09533469
42PDGFRA1.06119876
43MATK1.03789876
44BLK1.02139539
45PRKG20.99433066
46HCK0.97314276
47MAP2K30.95225625
48CAMKK10.94627645
49ICK0.91922445
50NEK90.90088526
51ZAP700.90049369
52LATS10.87986696
53ROCK10.86187752
54CDK60.82678220
55MAPK70.79602101
56TAOK20.79006824
57CSK0.78344513
58PAK60.77382405
59MAPKAPK30.76929094
60PIM20.75734421
61IRAK40.73942292
62FES0.73428982
63MAP3K60.72654418
64ROCK20.71532269
65MAPKAPK50.69990828
66DAPK30.68974971
67CDK30.68203228
68FGFR40.67203613
69PTK2B0.66784085
70MAPKAPK20.65539794
71PIK3CG0.64787888
72CAMK40.64710199
73MAP4K10.63713982
74FRK0.62678611
75JAK20.62329922
76ACVR1B0.60054357
77ITK0.59675496
78ILK0.59511175
79PDK10.58324929
80MAP3K70.56531241
81MAP2K10.56239750
82KIT0.55720333
83INSRR0.55014609
84RIPK10.54589381
85TGFBR10.54056634
86LCK0.53727940
87SCYL20.52887276
88TTN0.52776994
89TRPM70.52276214
90CHUK0.51554390
91IGF1R0.51377242
92HIPK20.51002502
93PRKCE0.50812856
94DMPK0.49857534
95PRKD10.49069904
96LYN0.47394393
97IRAK30.47228885
98RET0.46308523
99RPS6KA40.46253031
100GSK3A0.46173891
101MARK20.46129194
102RPS6KA20.46038405
103MAP3K140.46001752
104INSR0.45463621
105PDPK10.43756826
106CAMK2G0.43472644
107MAP3K30.42395898
108PINK10.42258416
109MAP3K90.41979779
110LRRK20.41215669
111ADRBK20.41094237
112FGFR20.40810473
113SIK20.39895785
114STK30.39618478
115IKBKB0.38668485
116PRKCD0.38270054
117MAPK40.37920020
118PDGFRB0.37768215
119MAP3K130.37489411
120GRK50.36782687
121MTOR0.36232449
122CAMK10.35975257
123BTK0.35789290
124TIE10.35346421
125FLT30.34154864
126MAP3K80.34109715
127MET0.34053083
128PAK30.33492696
129STK110.32949408
130GRK60.31633975
131IKBKE0.31460976
132RPS6KC10.30860068
133RPS6KL10.30860068
134RPS6KA60.30195976
135PKN10.29179174
136PRKG10.28325191
137PIK3CA0.28325079
138SIK10.26493538
139EPHA30.25652402
140ABL10.24878310
141EGFR0.24697484
142SRC0.22814236
143LATS20.22068630
144EPHB20.21776152
145PRKCH0.21612175
146MAP2K20.21457930

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.48979306
2Other glycan degradation_Homo sapiens_hsa005114.10839216
3Staphylococcus aureus infection_Homo sapiens_hsa051503.93425979
4Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.54828260
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.43374401
6Prion diseases_Homo sapiens_hsa050202.51374906
7Lysosome_Homo sapiens_hsa041422.50131944
8Osteoclast differentiation_Homo sapiens_hsa043802.39825568
9Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.14136592
10Pertussis_Homo sapiens_hsa051331.96981697
11B cell receptor signaling pathway_Homo sapiens_hsa046621.77067961
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.72154408
13Antigen processing and presentation_Homo sapiens_hsa046121.70714211
14Leishmaniasis_Homo sapiens_hsa051401.70664634
15Renin-angiotensin system_Homo sapiens_hsa046141.62579540
16Chronic myeloid leukemia_Homo sapiens_hsa052201.56984505
17Cyanoamino acid metabolism_Homo sapiens_hsa004601.50462091
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.50065087
19Mineral absorption_Homo sapiens_hsa049781.44315552
20Sulfur metabolism_Homo sapiens_hsa009201.39878612
21Toxoplasmosis_Homo sapiens_hsa051451.38773764
22Pancreatic cancer_Homo sapiens_hsa052121.31132080
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.24187474
24Colorectal cancer_Homo sapiens_hsa052101.23822111
25Intestinal immune network for IgA production_Homo sapiens_hsa046721.21692054
26Platelet activation_Homo sapiens_hsa046111.21667712
27Focal adhesion_Homo sapiens_hsa045101.20074719
28Legionellosis_Homo sapiens_hsa051341.16013860
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.14597296
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.14223894
31Adherens junction_Homo sapiens_hsa045201.12686148
32Tuberculosis_Homo sapiens_hsa051521.12381571
33Estrogen signaling pathway_Homo sapiens_hsa049151.11472769
34ECM-receptor interaction_Homo sapiens_hsa045121.09517189
35Endocytosis_Homo sapiens_hsa041441.08271744
36Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08160169
37Renal cell carcinoma_Homo sapiens_hsa052111.06453191
38Malaria_Homo sapiens_hsa051441.05531014
39Complement and coagulation cascades_Homo sapiens_hsa046101.05306023
40Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.04027887
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03397953
42Asthma_Homo sapiens_hsa053101.03068618
43Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.02713616
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.99737448
45Melanoma_Homo sapiens_hsa052180.99509489
46Bladder cancer_Homo sapiens_hsa052190.99116730
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.96894908
48Notch signaling pathway_Homo sapiens_hsa043300.95151352
49Amoebiasis_Homo sapiens_hsa051460.90141840
50Rap1 signaling pathway_Homo sapiens_hsa040150.89930824
51TGF-beta signaling pathway_Homo sapiens_hsa043500.88994741
52Proteoglycans in cancer_Homo sapiens_hsa052050.87726550
53Chemokine signaling pathway_Homo sapiens_hsa040620.86284651
54Hepatitis B_Homo sapiens_hsa051610.82764226
55Nitrogen metabolism_Homo sapiens_hsa009100.82291005
56Hematopoietic cell lineage_Homo sapiens_hsa046400.82018715
57Glioma_Homo sapiens_hsa052140.81507716
58Measles_Homo sapiens_hsa051620.81321147
59Salmonella infection_Homo sapiens_hsa051320.81311578
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.78790589
61Regulation of actin cytoskeleton_Homo sapiens_hsa048100.78469723
62Influenza A_Homo sapiens_hsa051640.77304106
63Arachidonic acid metabolism_Homo sapiens_hsa005900.76182497
64Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75081962
65Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72852558
66Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72337421
67Phagosome_Homo sapiens_hsa041450.72084211
68TNF signaling pathway_Homo sapiens_hsa046680.71156224
69Allograft rejection_Homo sapiens_hsa053300.69829826
70Dilated cardiomyopathy_Homo sapiens_hsa054140.68502547
71Graft-versus-host disease_Homo sapiens_hsa053320.68396091
72Hedgehog signaling pathway_Homo sapiens_hsa043400.68344260
73Shigellosis_Homo sapiens_hsa051310.68202367
74MAPK signaling pathway_Homo sapiens_hsa040100.67838005
75Apoptosis_Homo sapiens_hsa042100.67220081
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65950316
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65066161
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.61573939
79Non-small cell lung cancer_Homo sapiens_hsa052230.61247475
80Sphingolipid metabolism_Homo sapiens_hsa006000.60916454
81Gap junction_Homo sapiens_hsa045400.60902493
82Basal cell carcinoma_Homo sapiens_hsa052170.60198838
83Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59642458
84VEGF signaling pathway_Homo sapiens_hsa043700.59351510
85Autoimmune thyroid disease_Homo sapiens_hsa053200.58899417
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.58694691
87HTLV-I infection_Homo sapiens_hsa051660.58619612
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58446963
89Pathways in cancer_Homo sapiens_hsa052000.58401227
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58065927
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57877195
92Axon guidance_Homo sapiens_hsa043600.56940663
93Acute myeloid leukemia_Homo sapiens_hsa052210.56383079
94Protein digestion and absorption_Homo sapiens_hsa049740.55840406
95N-Glycan biosynthesis_Homo sapiens_hsa005100.54522857
96African trypanosomiasis_Homo sapiens_hsa051430.53998241
97GnRH signaling pathway_Homo sapiens_hsa049120.52342106
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52319030
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52113313
100MicroRNAs in cancer_Homo sapiens_hsa052060.51440257
101Viral myocarditis_Homo sapiens_hsa054160.50851482
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49960238
103Calcium signaling pathway_Homo sapiens_hsa040200.49679808
104HIF-1 signaling pathway_Homo sapiens_hsa040660.49383937
105Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48910545
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48714246
107FoxO signaling pathway_Homo sapiens_hsa040680.47425943
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.47187299
109Prostate cancer_Homo sapiens_hsa052150.46846216
110PPAR signaling pathway_Homo sapiens_hsa033200.46086366
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46028508
112Renin secretion_Homo sapiens_hsa049240.45900916
113Ras signaling pathway_Homo sapiens_hsa040140.44777727
114Melanogenesis_Homo sapiens_hsa049160.44622150
115mTOR signaling pathway_Homo sapiens_hsa041500.44455057
116Small cell lung cancer_Homo sapiens_hsa052220.43968531
117Rheumatoid arthritis_Homo sapiens_hsa053230.43711280
118Cocaine addiction_Homo sapiens_hsa050300.43396860
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43345758
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43262845
121Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42678730
122Choline metabolism in cancer_Homo sapiens_hsa052310.41494544
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.40969028
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40502399
125Jak-STAT signaling pathway_Homo sapiens_hsa046300.40355829
126Vibrio cholerae infection_Homo sapiens_hsa051100.40348336
127Glutathione metabolism_Homo sapiens_hsa004800.39800444
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39733496
129Adipocytokine signaling pathway_Homo sapiens_hsa049200.39475016
130ErbB signaling pathway_Homo sapiens_hsa040120.39204028
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37671771
132Hepatitis C_Homo sapiens_hsa051600.37403530
133NF-kappa B signaling pathway_Homo sapiens_hsa040640.36448611
134Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.34955214
135Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.32696161
136Thyroid hormone synthesis_Homo sapiens_hsa049180.32615997

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