TMEM120A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1low-density lipoprotein particle clearance (GO:0034383)5.41797029
2triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.07035102
3L-phenylalanine metabolic process (GO:0006558)4.79217845
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.79217845
5alpha-linolenic acid metabolic process (GO:0036109)4.69480114
6sulfur amino acid catabolic process (GO:0000098)4.68800693
7L-phenylalanine catabolic process (GO:0006559)4.66021662
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.66021662
9cysteine metabolic process (GO:0006534)4.56318217
10regulation of triglyceride catabolic process (GO:0010896)4.56283200
11serine family amino acid catabolic process (GO:0009071)4.48041407
12plasma lipoprotein particle clearance (GO:0034381)4.43690816
13regulation of sequestering of triglyceride (GO:0010889)4.35130378
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.34384504
15urea cycle (GO:0000050)4.25173420
16urea metabolic process (GO:0019627)4.25173420
17biotin metabolic process (GO:0006768)4.11349987
18valine metabolic process (GO:0006573)4.06557338
19aromatic amino acid family catabolic process (GO:0009074)4.06262395
20amino-acid betaine metabolic process (GO:0006577)4.05209621
21glyoxylate metabolic process (GO:0046487)3.98354661
22acylglycerol homeostasis (GO:0055090)3.95422651
23triglyceride homeostasis (GO:0070328)3.95422651
24nitrogen cycle metabolic process (GO:0071941)3.95119761
25triglyceride catabolic process (GO:0019433)3.93790909
26fatty acid beta-oxidation (GO:0006635)3.92833150
27glycine metabolic process (GO:0006544)3.90380333
28regulation of cholesterol storage (GO:0010885)3.89152580
29complement activation, alternative pathway (GO:0006957)3.88839440
30homocysteine metabolic process (GO:0050667)3.74353162
31serine family amino acid metabolic process (GO:0009069)3.74054614
32lysine metabolic process (GO:0006553)3.73543944
33lysine catabolic process (GO:0006554)3.73543944
34fatty acid oxidation (GO:0019395)3.70275256
35regulation of cholesterol esterification (GO:0010872)3.67882133
36acylglycerol catabolic process (GO:0046464)3.67748807
37neutral lipid catabolic process (GO:0046461)3.67748807
38positive regulation of lipid catabolic process (GO:0050996)3.67423547
39positive regulation of fatty acid beta-oxidation (GO:0032000)3.65610047
40positive regulation of lipoprotein lipase activity (GO:0051006)3.65206841
41positive regulation of triglyceride lipase activity (GO:0061365)3.65206841
42fructose metabolic process (GO:0006000)3.62947824
43high-density lipoprotein particle remodeling (GO:0034375)3.62936296
44lipid oxidation (GO:0034440)3.62706268
45acetyl-CoA metabolic process (GO:0006084)3.60042058
46fatty acid catabolic process (GO:0009062)3.59433964
47negative regulation of fibrinolysis (GO:0051918)3.59089421
48tryptophan catabolic process (GO:0006569)3.57965130
49indole-containing compound catabolic process (GO:0042436)3.57965130
50indolalkylamine catabolic process (GO:0046218)3.57965130
51angiotensin maturation (GO:0002003)3.57906980
52kynurenine metabolic process (GO:0070189)3.53448297
53NADH metabolic process (GO:0006734)3.53183985
54pantothenate metabolic process (GO:0015939)3.50568700
55fatty acid transmembrane transport (GO:1902001)3.47550900
56bile acid biosynthetic process (GO:0006699)3.46612527
57serine family amino acid biosynthetic process (GO:0009070)3.46465920
58branched-chain amino acid catabolic process (GO:0009083)3.46080098
59regulation of protein activation cascade (GO:2000257)3.44703981
60folic acid metabolic process (GO:0046655)3.43608169
61protein carboxylation (GO:0018214)3.41547289
62peptidyl-glutamic acid carboxylation (GO:0017187)3.41547289
63epoxygenase P450 pathway (GO:0019373)3.38327053
64carnitine metabolic process (GO:0009437)3.37213382
65tryptophan metabolic process (GO:0006568)3.34667694
66positive regulation of triglyceride metabolic process (GO:0090208)3.34531472
67plasma lipoprotein particle remodeling (GO:0034369)3.34484056
68protein-lipid complex remodeling (GO:0034368)3.34484056
69macromolecular complex remodeling (GO:0034367)3.34484056
70branched-chain amino acid metabolic process (GO:0009081)3.34387251
71antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33959313
72positive regulation of fatty acid oxidation (GO:0046321)3.32505791
73triglyceride biosynthetic process (GO:0019432)3.32380555
74reverse cholesterol transport (GO:0043691)3.31483317
75phospholipid efflux (GO:0033700)3.31278326
762-oxoglutarate metabolic process (GO:0006103)3.31002747
77regulation of complement activation (GO:0030449)3.30581747
78folic acid transport (GO:0015884)3.27159762
79alpha-amino acid catabolic process (GO:1901606)3.27040402
80plasma lipoprotein particle assembly (GO:0034377)3.23613598
81aromatic amino acid family metabolic process (GO:0009072)3.22529346
82acylglycerol biosynthetic process (GO:0046463)3.21467680
83neutral lipid biosynthetic process (GO:0046460)3.21467680
84monocarboxylic acid catabolic process (GO:0072329)3.21016432
85triglyceride metabolic process (GO:0006641)3.20571446
86bile acid metabolic process (GO:0008206)3.19031787
87regulation of fatty acid beta-oxidation (GO:0031998)3.17879333
88regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.17852614
89cellular amino acid catabolic process (GO:0009063)3.15627270
90regulation of fibrinolysis (GO:0051917)3.15550518
91positive regulation of fatty acid metabolic process (GO:0045923)3.14857875
92organic acid catabolic process (GO:0016054)3.12307815
93carboxylic acid catabolic process (GO:0046395)3.12307815
94cholesterol homeostasis (GO:0042632)3.10684652
95diacylglycerol metabolic process (GO:0046339)3.10572117
96very-low-density lipoprotein particle assembly (GO:0034379)3.10539811
97protein-lipid complex assembly (GO:0065005)3.09411972
98negative regulation of fatty acid biosynthetic process (GO:0045717)3.08553831
99sterol homeostasis (GO:0055092)3.08047053
100urate metabolic process (GO:0046415)3.07480609
101negative regulation of sterol transport (GO:0032372)3.06515976
102negative regulation of cholesterol transport (GO:0032375)3.06515976
103phospholipid homeostasis (GO:0055091)3.05599834
104negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.04054315
105lipoprotein metabolic process (GO:0042157)3.03757489
106regulation of cholesterol homeostasis (GO:2000188)3.02942226
107alditol metabolic process (GO:0019400)3.02290611
108acylglycerol metabolic process (GO:0006639)2.99880246
109antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.97571812
110fat-soluble vitamin biosynthetic process (GO:0042362)2.93952764
111antigen processing and presentation of endogenous antigen (GO:0019883)2.84837225
112oxaloacetate metabolic process (GO:0006107)2.84108153
113hormone catabolic process (GO:0042447)2.75280096
114cholesterol efflux (GO:0033344)2.73817790
115antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71153787
116detection of bacterium (GO:0016045)2.70851309
117detection of other organism (GO:0098543)2.70558798
118negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.68201274
119negative regulation of cell killing (GO:0031342)2.68201274
120positive regulation of Cdc42 GTPase activity (GO:0043089)2.65451690
121modulation by symbiont of host defense response (GO:0052031)2.61266598
122modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.61266598
123modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.61266598
124positive regulation by organism of defense response of other organism involved in symbiotic interact2.61266598
125modulation by symbiont of host immune response (GO:0052553)2.61266598
126positive regulation by symbiont of host defense response (GO:0052509)2.61266598
127lipoprotein transport (GO:0042953)2.59877031
128regulation of interferon-beta biosynthetic process (GO:0045357)2.56149468
129drug metabolic process (GO:0017144)2.54585592
130plasma lipoprotein particle organization (GO:0071827)2.52120032
131protein-lipid complex subunit organization (GO:0071825)2.48706634
132macrophage activation involved in immune response (GO:0002281)2.48110100
133GDP-mannose metabolic process (GO:0019673)2.47925414
134detection of external biotic stimulus (GO:0098581)2.46469804
135peptide catabolic process (GO:0043171)2.45890812
136ethanol oxidation (GO:0006069)2.45852841
137creatine metabolic process (GO:0006600)2.42105570
138regulation of cellular extravasation (GO:0002691)2.41950958
139barbed-end actin filament capping (GO:0051016)2.41184802
140intestinal absorption (GO:0050892)2.37895177
141positive regulation of fatty acid biosynthetic process (GO:0045723)2.37293899
142acute-phase response (GO:0006953)2.36905363
143sexual reproduction (GO:0019953)2.33477851
144detection of molecule of bacterial origin (GO:0032490)2.30108571
145regulation of sterol transport (GO:0032371)2.28471300
146regulation of cholesterol transport (GO:0032374)2.28471300
147regulation of triglyceride metabolic process (GO:0090207)2.27821480
148cell wall macromolecule catabolic process (GO:0016998)2.26846820
149cellular response to zinc ion (GO:0071294)2.24451225
150adhesion of symbiont to host (GO:0044406)2.23751316
151bile acid and bile salt transport (GO:0015721)2.20688277
152positive regulation of cellular amine metabolic process (GO:0033240)2.19607096
153regulation of cytokine secretion involved in immune response (GO:0002739)2.18361607
154glycosphingolipid catabolic process (GO:0046479)2.17335411
155neutrophil activation involved in immune response (GO:0002283)2.17184348
156nucleoside diphosphate biosynthetic process (GO:0009133)2.15645801
157negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.15093018
158type I interferon signaling pathway (GO:0060337)2.12832645
159cellular response to type I interferon (GO:0071357)2.12832645
160maintenance of gastrointestinal epithelium (GO:0030277)2.12410927

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.31888763
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.43927946
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.80139216
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.44051754
5TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.61609216
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.58705855
7* LXR_22158963_ChIP-Seq_LIVER_Mouse3.48668830
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.34607821
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.29158993
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.88460706
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.64875046
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44454530
13CLOCK_20551151_ChIP-Seq_293T_Human2.38254643
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00606161
15RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92673077
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.89130937
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.87639594
18CREB1_15753290_ChIP-ChIP_HEK293T_Human1.81941767
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.79168661
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78622485
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.78610461
22STAT3_1855785_ChIP-Seq_MESCs_Mouse1.77902347
23MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76651511
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.74602024
25MYC_18555785_ChIP-Seq_MESCs_Mouse1.73284534
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71510712
27ZNF263_19887448_ChIP-Seq_K562_Human1.69598403
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.68463497
29VDR_21846776_ChIP-Seq_THP-1_Human1.62429682
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.59766203
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.59640848
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58708916
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53810328
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53351164
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.49215809
36SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45957008
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44005640
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42828697
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41913417
40VDR_24763502_ChIP-Seq_THP-1_Human1.41751145
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40413022
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.40183047
43* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36152774
44CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.36097404
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35579621
46TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34456896
47AR_21909140_ChIP-Seq_LNCAP_Human1.33351469
48* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.33324502
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.32430960
50P68_20966046_ChIP-Seq_HELA_Human1.32174953
51NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32002089
52SA1_27219007_Chip-Seq_Bcells_Human1.29247973
53PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.29198945
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29125840
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28056553
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26761843
57LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.26442428
58GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25336529
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24537492
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24207805
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.24131397
62NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.23428986
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.23171938
64DCP1A_22483619_ChIP-Seq_HELA_Human1.22749539
65ELF1_20517297_ChIP-Seq_JURKAT_Human1.22580157
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20435703
67SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.18603828
68SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.18515921
69SMC4_20622854_ChIP-Seq_HELA_Human1.18477220
70STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18469218
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.17305187
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.16907423
73MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15679734
74NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15621660
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.14582821
76KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13949640
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13348944
78MYC_19079543_ChIP-ChIP_MESCs_Mouse1.12697094
79* KDM2B_26808549_Chip-Seq_DND41_Human1.12426087
80RAD21_21589869_ChIP-Seq_MESCs_Mouse1.11777779
81GATA1_19941827_ChIP-Seq_MEL_Mouse1.11337509
82TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.11118733
83CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10953988
84ATF3_27146783_Chip-Seq_COLON_Human1.10417541
85UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.09682803
86GABP_19822575_ChIP-Seq_HepG2_Human1.09143368
87SPI1_23127762_ChIP-Seq_K562_Human1.07950711
88PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07071379
89NANOG_18555785_ChIP-Seq_MESCs_Mouse1.06270377
90IKZF1_21737484_ChIP-ChIP_HCT116_Human1.04345321
91RXRA_24833708_ChIP-Seq_LIVER_Mouse1.04120522
92PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03980013
93EST1_17652178_ChIP-ChIP_JURKAT_Human1.03102632
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.02984274
95E2F1_20622854_ChIP-Seq_HELA_Human1.02443013
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02315771
97TCF7_22412390_ChIP-Seq_EML_Mouse1.02096040
98XRN2_22483619_ChIP-Seq_HELA_Human1.02063811
99MAF_26560356_Chip-Seq_TH1_Human1.01763444
100CTCF_27219007_Chip-Seq_Bcells_Human1.01425855
101KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.01350045
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.01340426
103CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01265753
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.01262662
105UTX_26944678_Chip-Seq_JUKART_Human1.00966926
106CTCF_26484167_Chip-Seq_Bcells_Mouse0.98863128
107GATA1_22383799_ChIP-Seq_G1ME_Mouse0.98384617
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97527105
109EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96920842
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96409485
111POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95697592
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95353970
113SRF_21415370_ChIP-Seq_HL-1_Mouse0.95292246
114ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.95043725
115PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.94978172
116IRF8_22096565_ChIP-ChIP_GC-B_Human0.94228121
117RARA_24833708_ChIP-Seq_LIVER_Mouse0.94201241
118GATA2_21666600_ChIP-Seq_HMVEC_Human0.93680252
119PHF8_20622854_ChIP-Seq_HELA_Human0.93494207
120CTCF_20526341_ChIP-Seq_ESCs_Human0.93291267
121OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92239004
122STAT6_21828071_ChIP-Seq_BEAS2B_Human0.92152995
123ETS1_21867929_ChIP-Seq_TH2_Mouse0.91635711
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.91509040
125HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90143391
126IRF8_21731497_ChIP-ChIP_J774_Mouse0.89986801
127BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88814226
128YY1_21170310_ChIP-Seq_MESCs_Mouse0.88496065
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88376665
130BCOR_27268052_Chip-Seq_Bcells_Human0.88111232
131ZFX_18555785_ChIP-Seq_MESCs_Mouse0.87859289
132NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.87291314
133RARB_24833708_ChIP-Seq_LIVER_Mouse0.86211534
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86188938
135RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85866400
136CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85023813
137DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84560632
138BCL6_27268052_Chip-Seq_Bcells_Human0.84423684
139MYCN_18555785_ChIP-Seq_MESCs_Mouse0.84098551
140GATA4_25053715_ChIP-Seq_YYC3_Human0.83968903
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83776874
142PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83653291
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.83048797
144* KAP1_22055183_ChIP-Seq_ESCs_Mouse0.82978028
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82950694
146VDR_23849224_ChIP-Seq_CD4+_Human0.82615685
147* HNF4A_19822575_ChIP-Seq_HepG2_Human0.79837182
148RACK7_27058665_Chip-Seq_MCF-7_Human0.79115810
149* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78527530
150HIF1A_21447827_ChIP-Seq_MCF-7_Human0.78202409
151NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.77665000
152* CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.77575113
153KDM5A_27292631_Chip-Seq_BREAST_Human0.76035676
154THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.75930526
155PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.75818168
156BRD4_27068464_Chip-Seq_AML-cells_Mouse0.75616824
157SOX2_27498859_Chip-Seq_STOMACH_Mouse0.74036283
158LXR_22292898_ChIP-Seq_THP-1_Human0.73986520
159* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.72640438
160* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.72301400
161P300_27268052_Chip-Seq_Bcells_Human0.72033545
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.71931848
163TFEB_21752829_ChIP-Seq_HELA_Human0.71748128

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis5.67989562
2MP0002139_abnormal_hepatobiliary_system5.55221433
3MP0005365_abnormal_bile_salt4.41894190
4MP0005670_abnormal_white_adipose4.09907006
5MP0009840_abnormal_foam_cell3.96730944
6MP0005085_abnormal_gallbladder_physiolo3.78159257
7MP0010329_abnormal_lipoprotein_level3.39947074
8MP0003191_abnormal_cellular_cholesterol3.08274480
9MP0003806_abnormal_nucleotide_metabolis2.90716898
10MP0008875_abnormal_xenobiotic_pharmacok2.90594211
11MP0005666_abnormal_adipose_tissue2.62756081
12MP0005332_abnormal_amino_acid2.52139633
13MP0004510_myositis2.46378920
14MP0003705_abnormal_hypodermis_morpholog2.23952902
15MP0003186_abnormal_redox_activity2.23092299
16MP0004019_abnormal_vitamin_homeostasis2.21516084
17MP0000609_abnormal_liver_physiology2.11697332
18MP0002118_abnormal_lipid_homeostasis2.07166204
19MP0003303_peritoneal_inflammation2.00965564
20MP0003252_abnormal_bile_duct1.96934347
21MP0001666_abnormal_nutrient_absorption1.96332755
22MP0004185_abnormal_adipocyte_glucose1.93312917
23MP0008438_abnormal_cutaneous_collagen1.92548995
24MP0004130_abnormal_muscle_cell1.83962091
25MP0001764_abnormal_homeostasis1.81818960
26MP0005319_abnormal_enzyme/_coenzyme1.77350072
27MP0005083_abnormal_biliary_tract1.67370399
28MP0002971_abnormal_brown_adipose1.66839520
29MP0002419_abnormal_innate_immunity1.64335868
30MP0005025_abnormal_response_to1.63855984
31MP0010155_abnormal_intestine_physiology1.62957008
32MP0003183_abnormal_peptide_metabolism1.61688812
33MP0002876_abnormal_thyroid_physiology1.59123463
34MP0005375_adipose_tissue_phenotype1.56696519
35MP0005451_abnormal_body_composition1.53992524
36MP0009115_abnormal_fat_cell1.53948006
37MP0009643_abnormal_urine_homeostasis1.47994862
38MP0005166_decreased_susceptibility_to1.44759902
39MP0002148_abnormal_hypersensitivity_rea1.44263590
40MP0003828_pulmonary_edema1.43649041
41MP0003075_altered_response_to1.38343216
42MP0002132_abnormal_respiratory_system1.38109859
43MP0003195_calcinosis1.38042356
44MP0005334_abnormal_fat_pad1.34513517
45MP0000685_abnormal_immune_system1.34050036
46MP0000751_myopathy1.33866690
47MP0001790_abnormal_immune_system1.33152420
48MP0005387_immune_system_phenotype1.33152420
49MP0000749_muscle_degeneration1.30528776
50MP0005000_abnormal_immune_tolerance1.29843012
51MP0001661_extended_life_span1.24875686
52MP0000598_abnormal_liver_morphology1.22953583
53MP0001756_abnormal_urination1.21267464
54MP0005275_abnormal_skin_tensile1.19410503
55MP0001835_abnormal_antigen_presentation1.19177834
56MP0003011_delayed_dark_adaptation1.19105672
57MP0003718_maternal_effect1.18267272
58MP0003300_gastrointestinal_ulcer1.17687985
59MP0005584_abnormal_enzyme/coenzyme_acti1.17023328
60MP0005058_abnormal_lysosome_morphology1.16148847
61MP0002970_abnormal_white_adipose1.13980230
62MP0006036_abnormal_mitochondrial_physio1.13615057
63MP0003329_amyloid_beta_deposits1.11765159
64MP0005330_cardiomyopathy1.11737701
65MP0005671_abnormal_response_to1.10477565
66MP0002723_abnormal_immune_serum1.10440779
67MP0002138_abnormal_hepatobiliary_system1.09508828
68MP0003693_abnormal_embryo_hatching1.07847072
69MP0002332_abnormal_exercise_endurance1.07551969
70MP0003866_abnormal_defecation1.05510680
71MP0004858_abnormal_nervous_system1.05045183
72MP0001800_abnormal_humoral_immune1.03826801
73MP0002254_reproductive_system_inflammat1.03113334
74MP0003172_abnormal_lysosome_physiology1.02299645
75MP0008004_abnormal_stomach_pH1.02278531
76MP0003436_decreased_susceptibility_to1.01944301
77MP0002452_abnormal_antigen_presenting0.98252606
78MP0005448_abnormal_energy_balance0.94778895
79MP0005084_abnormal_gallbladder_morpholo0.93287878
80MP0008469_abnormal_protein_level0.92822922
81MP0005165_increased_susceptibility_to0.92500341
82MP0005464_abnormal_platelet_physiology0.91648481
83MP0009333_abnormal_splenocyte_physiolog0.91529999
84MP0001819_abnormal_immune_cell0.90776642
85MP0002796_impaired_skin_barrier0.90142865
86MP0002420_abnormal_adaptive_immunity0.89864160
87MP0009763_increased_sensitivity_to0.89798015
88MP0000249_abnormal_blood_vessel0.88883855
89MP0003868_abnormal_feces_composition0.88255319
90MP0003879_abnormal_hair_cell0.88118881
91MP0004947_skin_inflammation0.86516821
92MP0006138_congestive_heart_failure0.86029856
93MP0001881_abnormal_mammary_gland0.85706282
94MP0002136_abnormal_kidney_physiology0.84945060
95MP0003221_abnormal_cardiomyocyte_apopto0.84146124
96MP0002998_abnormal_bone_remodeling0.83426419
97MP0005023_abnormal_wound_healing0.83240889
98MP0000604_amyloidosis0.83218678
99MP0005395_other_phenotype0.83097344
100MP0009764_decreased_sensitivity_to0.82769916
101MP0005535_abnormal_body_temperature0.80567556
102MP0005376_homeostasis/metabolism_phenot0.80532248
103MP0009697_abnormal_copulation0.79950093
104MP0003279_aneurysm0.79780984
105MP0002078_abnormal_glucose_homeostasis0.79414311
106MP0003724_increased_susceptibility_to0.77747813
107MP0009642_abnormal_blood_homeostasis0.77583487
108MP0002933_joint_inflammation0.77109737
109MP0000747_muscle_weakness0.74619693
110MP0002837_dystrophic_cardiac_calcinosis0.74618372
111MP0000858_altered_metastatic_potential0.74488209
112MP0004264_abnormal_extraembryonic_tissu0.74035798
113MP0005636_abnormal_mineral_homeostasis0.73900588
114MP0004883_abnormal_blood_vessel0.73290783
115MP0001727_abnormal_embryo_implantation0.72157764
116MP0003690_abnormal_glial_cell0.72146744
117MP0002060_abnormal_skin_morphology0.69851636
118MP0003656_abnormal_erythrocyte_physiolo0.67977057
119MP0001853_heart_inflammation0.67646333
120MP0003959_abnormal_lean_body0.66568361
121MP0000343_altered_response_to0.66428539
122MP0004782_abnormal_surfactant_physiolog0.64834061
123MP0005647_abnormal_sex_gland0.64643048
124MP0008260_abnormal_autophagy0.64298168
125MP0005266_abnormal_metabolism0.64039108
126MP0000750_abnormal_muscle_regeneration0.63943281
127MP0006035_abnormal_mitochondrial_morpho0.63906652
128MP0001545_abnormal_hematopoietic_system0.62778795
129MP0005397_hematopoietic_system_phenotyp0.62778795
130MP0001542_abnormal_bone_strength0.62639604
131MP0001533_abnormal_skeleton_physiology0.62439395
132MP0006082_CNS_inflammation0.61989224
133MP0003566_abnormal_cell_adhesion0.61284055
134MP0000013_abnormal_adipose_tissue0.60733091
135MP0010352_gastrointestinal_tract_polyps0.60321861
136MP0005164_abnormal_response_to0.58390186
137MP0000358_abnormal_cell_content/0.58360531
138MP0005410_abnormal_fertilization0.57454320
139MP0009053_abnormal_anal_canal0.57444917
140MP0000003_abnormal_adipose_tissue0.56446029
141MP0009785_altered_susceptibility_to0.52933949
142MP0004957_abnormal_blastocyst_morpholog0.52158106
143MP0005452_abnormal_adipose_tissue0.51871158
144MP0001845_abnormal_inflammatory_respons0.50832627
145MP0009672_abnormal_birth_weight0.50567543
146MP0003646_muscle_fatigue0.49590372
147MP0002135_abnormal_kidney_morphology0.47989931

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)5.74260046
2Xanthomatosis (HP:0000991)5.14326112
3Abnormality of serine family amino acid metabolism (HP:0010894)4.98728431
4Abnormality of glycine metabolism (HP:0010895)4.98728431
5Hyperglycinemia (HP:0002154)4.85664903
6Abnormality of aromatic amino acid family metabolism (HP:0004338)4.49784661
7Hypobetalipoproteinemia (HP:0003563)4.46624030
8Hyperammonemia (HP:0001987)4.33568228
9Hyperlipoproteinemia (HP:0010980)4.32902850
10Abnormality of monocarboxylic acid metabolism (HP:0010996)4.28308240
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.19222389
12Deep venous thrombosis (HP:0002625)4.12956511
13Hypolipoproteinemia (HP:0010981)4.08380184
14Hypoalphalipoproteinemia (HP:0003233)4.05671300
15Complement deficiency (HP:0004431)4.02501966
16Abnormality of fatty-acid metabolism (HP:0004359)4.01182938
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.80692899
18Intrahepatic cholestasis (HP:0001406)3.75326262
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.62880997
20Hypertriglyceridemia (HP:0002155)3.49807768
21Ketosis (HP:0001946)3.47740171
22Eczematoid dermatitis (HP:0000976)3.42552682
23Abnormality of serum amino acid levels (HP:0003112)3.41871621
24Oligomenorrhea (HP:0000876)3.37980404
25Abnormality of macrophages (HP:0004311)3.37653011
26Epidermoid cyst (HP:0200040)3.35570252
27Asymmetric septal hypertrophy (HP:0001670)3.28883040
28Nausea (HP:0002018)3.28195901
29Dicarboxylic aciduria (HP:0003215)3.23606449
30Abnormality of dicarboxylic acid metabolism (HP:0010995)3.23606449
31Prolonged partial thromboplastin time (HP:0003645)3.17767428
32Myocardial infarction (HP:0001658)3.16691887
33Abnormality of complement system (HP:0005339)3.15903479
34Hypoglycemic coma (HP:0001325)3.14360683
35Abnormality of sulfur amino acid metabolism (HP:0004339)3.13920089
36Abnormality of proline metabolism (HP:0010907)3.10615049
37Hydroxyprolinuria (HP:0003080)3.10615049
38Abnormality of aspartate family amino acid metabolism (HP:0010899)3.08079168
39Gout (HP:0001997)2.96919112
40Abnormality of purine metabolism (HP:0004352)2.96854138
41Hypercholesterolemia (HP:0003124)2.95968254
42Multiple enchondromatosis (HP:0005701)2.95242556
43Lethargy (HP:0001254)2.94737640
44Amyloidosis (HP:0011034)2.92678798
45Abnormality of nucleobase metabolism (HP:0010932)2.90567023
46Systemic lupus erythematosus (HP:0002725)2.90374089
47Abnormal cartilage morphology (HP:0002763)2.84794051
48Abnormality of pyrimidine metabolism (HP:0004353)2.77992791
49Acanthosis nigricans (HP:0000956)2.76033104
50Recurrent abscess formation (HP:0002722)2.70157809
51Distal lower limb muscle weakness (HP:0009053)2.68818179
52Ileus (HP:0002595)2.65794617
53Abnormality of the common coagulation pathway (HP:0010990)2.63413304
54Abnormality of liposaccharide metabolism (HP:0010968)2.59223439
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.59223439
56Abnormality of glycolipid metabolism (HP:0010969)2.59223439
57Abnormality of methionine metabolism (HP:0010901)2.53403987
58Proximal tubulopathy (HP:0000114)2.51161630
59Fat malabsorption (HP:0002630)2.50373256
60Ketoacidosis (HP:0001993)2.48053803
61Increased purine levels (HP:0004368)2.46187894
62Hyperuricemia (HP:0002149)2.46187894
63Dysostosis multiplex (HP:0000943)2.45512394
64Joint hemorrhage (HP:0005261)2.44573376
65Gastrointestinal infarctions (HP:0005244)2.44388792
66Abnormality of the intrinsic pathway (HP:0010989)2.43808157
67Pancreatitis (HP:0001733)2.43557710
68Metabolic acidosis (HP:0001942)2.43525098
69Malnutrition (HP:0004395)2.42957193
70Cholecystitis (HP:0001082)2.39716754
71Abnormal gallbladder physiology (HP:0012438)2.39716754
72Rhabdomyolysis (HP:0003201)2.36422671
73Orchitis (HP:0100796)2.35709050
74Generalized aminoaciduria (HP:0002909)2.33476919
75Myopathic facies (HP:0002058)2.32863651
76Myositis (HP:0100614)2.32456145
77Bulbar palsy (HP:0001283)2.31939108
78Skin nodule (HP:0200036)2.31621195
79Recurrent bacterial skin infections (HP:0005406)2.24151739
80Vacuolated lymphocytes (HP:0001922)2.24116164
81Axonal loss (HP:0003447)2.22844574
82Petechiae (HP:0000967)2.22177343
83Brushfield spots (HP:0001088)2.18675303
84Vomiting (HP:0002013)2.18269438
85Purpura (HP:0000979)2.15731841
86Vertebral compression fractures (HP:0002953)2.15347662
87Muscle fiber splitting (HP:0003555)2.14344331
88Cerebral edema (HP:0002181)2.11112849
89Irritability (HP:0000737)2.11086765
90Hemorrhage of the eye (HP:0011885)2.08955388
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.08611443
92Abnormality of polysaccharide metabolism (HP:0011012)2.08611443
93Abnormality of glycosaminoglycan metabolism (HP:0004371)2.08611443
94Exercise-induced myalgia (HP:0003738)2.08192983
95Insulin resistance (HP:0000855)2.07276862
96Increased connective tissue (HP:0009025)2.07156157
97Obstructive lung disease (HP:0006536)2.02034831
98Chronic obstructive pulmonary disease (HP:0006510)2.02034831
99Mucopolysacchariduria (HP:0008155)2.00931516
100Urinary glycosaminoglycan excretion (HP:0003541)2.00931516
101Centrally nucleated skeletal muscle fibers (HP:0003687)2.00161198
102Gingivitis (HP:0000230)1.99763759
103Increased serum ferritin (HP:0003281)1.99364913
104Gingival bleeding (HP:0000225)1.98412157
105Growth hormone excess (HP:0000845)1.98348501
106Mediastinal lymphadenopathy (HP:0100721)1.97718501
107Delayed CNS myelination (HP:0002188)1.97057383
108Long foot (HP:0001833)1.96694704
109Joint swelling (HP:0001386)1.96611407
110Upper motor neuron abnormality (HP:0002127)1.95620730
111Increased muscle lipid content (HP:0009058)1.95285862
112Hyporeflexia of lower limbs (HP:0002600)1.94464669
113Loss of speech (HP:0002371)1.92718388
114Widely patent fontanelles and sutures (HP:0004492)1.91888199
115Spastic diplegia (HP:0001264)1.90252867
116Hyperglycemia (HP:0003074)1.89394891
117Progressive neurologic deterioration (HP:0002344)1.88214119
118Premature rupture of membranes (HP:0001788)1.88066216
119Increased variability in muscle fiber diameter (HP:0003557)1.86682336
120Myoglobinuria (HP:0002913)1.86561627
121Vascular calcification (HP:0004934)1.86130904
122Steatorrhea (HP:0002570)1.86077345
123Autoimmune thrombocytopenia (HP:0001973)1.85567309
124Abnormality of skeletal muscle fiber size (HP:0012084)1.84734769
125Nephritis (HP:0000123)1.84629602
126Hypophosphatemia (HP:0002148)1.84625032
127Abnormality of glycolysis (HP:0004366)1.84484714
128Increased serum pyruvate (HP:0003542)1.84484714
129Opisthotonus (HP:0002179)1.83358938
130Global brain atrophy (HP:0002283)1.82810330
131Esophageal varix (HP:0002040)1.82263824
132Megaloblastic anemia (HP:0001889)1.81898121
133Optic neuritis (HP:0100653)1.81566542
134Retrobulbar optic neuritis (HP:0100654)1.81566542
135Glomerulonephritis (HP:0000099)1.80698764
136Prolonged neonatal jaundice (HP:0006579)1.80613822
137Type 1 muscle fiber predominance (HP:0003803)1.79961334
138Polycythemia (HP:0001901)1.79851144
139Elevated erythrocyte sedimentation rate (HP:0003565)1.79575880
140Glycosuria (HP:0003076)1.79271933
141Abnormality of urine glucose concentration (HP:0011016)1.79271933
142Hepatocellular carcinoma (HP:0001402)1.78419365
143Abnormality of alkaline phosphatase activity (HP:0004379)1.78404417
144Recurrent gram-negative bacterial infections (HP:0005420)1.78048695
145Hyperbilirubinemia (HP:0002904)1.77093722
146Cardiovascular calcification (HP:0011915)1.76511004
147Cerebral palsy (HP:0100021)1.76249349
148Sensorimotor neuropathy (HP:0007141)1.76226546
149Abnormal enzyme/coenzyme activity (HP:0012379)1.75828729
150Congenital sensorineural hearing impairment (HP:0008527)1.75178640
151Insulin-resistant diabetes mellitus (HP:0000831)1.74991451
152Ventricular tachycardia (HP:0004756)1.74891348
153Reduced subcutaneous adipose tissue (HP:0003758)1.74433432
154Methylmalonic aciduria (HP:0012120)1.74230842
155Hepatosplenomegaly (HP:0001433)1.74120368
156Muscle fibrillation (HP:0010546)1.73967910
157Spontaneous abortion (HP:0005268)1.73761749
158CNS demyelination (HP:0007305)1.72893741
159Sudden death (HP:0001699)1.72829274
160Stomatitis (HP:0010280)1.72267668
161Abnormality of transition element cation homeostasis (HP:0011030)1.71825527
162Episodic fever (HP:0001954)1.71756003
163EMG: myopathic abnormalities (HP:0003458)1.70016982

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.06032998
2TRIB33.96612938
3ERN13.46047323
4PDK43.17307814
5PDK33.17307814
6BUB12.85027230
7TXK2.77857912
8NME22.67343216
9RIPK42.66998223
10SIK12.48993063
11EPHA22.34923744
12TESK12.34479534
13PDK22.21601694
14PRPF4B2.10807163
15TESK22.10466744
16EPHB12.08634482
17CAMK1D1.98448455
18EIF2AK11.89437449
19FGFR41.86404102
20MST1R1.75281420
21LATS21.71180912
22MAP3K31.63448328
23STK38L1.57302256
24ABL21.56275982
25GRK71.52790641
26PIM21.52604447
27MUSK1.52134047
28MAP4K11.50200612
29KDR1.50097609
30CSK1.46259375
31MAP3K121.45915364
32IRAK31.44878358
33MAP3K111.39958497
34IRAK41.39076472
35RPS6KA41.33469744
36NEK91.32873153
37NEK11.31376595
38NEK21.30275651
39MAP2K31.28512301
40WEE11.24126154
41TTN1.22931767
42MAP3K11.07929259
43TNK21.02334504
44PRKD21.02003776
45TYK21.01417700
46TTK0.99420973
47TBK10.97994678
48MAPK110.97662326
49TAOK20.96162456
50PKN20.95409541
51SIK30.94461074
52PDK10.94223396
53BRSK20.92473165
54LATS10.91146783
55BRAF0.91002464
56ERBB40.90903327
57AKT30.89988313
58MAPK120.88748744
59CDK40.87560890
60DYRK30.86388055
61PLK40.86124927
62JAK20.85636527
63PAK40.85219318
64EPHA30.84031468
65GRK50.83033974
66MAP2K20.82934945
67IKBKE0.82689350
68STK30.81726183
69CDK60.81230783
70MAP2K10.80944247
71SCYL20.80592651
72ARAF0.79848087
73MAP3K80.78170823
74MATK0.77489133
75JAK10.76770201
76KSR20.76457120
77OBSCN0.75235910
78ACVR1B0.74975707
79CDC42BPA0.73987475
80STK160.72345475
81MAP3K100.72323129
82JAK30.70854565
83DYRK20.70659732
84PRKD10.70022850
85DMPK0.69063026
86FRK0.68252599
87PIK3CG0.67790182
88GRK60.67751023
89SIK20.67710761
90STK380.66865708
91MAP3K50.65593417
92FES0.63763320
93TAOK10.63292348
94PIM10.62693887
95PRKAA20.61837633
96TGFBR20.59159000
97LRRK20.58691572
98PAK10.57748486
99PINK10.56826371
100MAP3K60.56603603
101DDR20.56033547
102ZAP700.55856390
103EPHB20.55453678
104PLK10.55122576
105FGR0.53681149
106PRKAA10.52694913
107SYK0.52612235
108BLK0.52056882
109MTOR0.51266803
110DYRK1B0.51037771
111EIF2AK30.50943452
112MAPKAPK30.50084051
113EIF2AK20.49212231
114CAMK1G0.48887764
115HCK0.47559082
116PRKD30.47232396
117STK100.46740033
118LYN0.46657756
119AURKA0.46007582
120RIPK10.45890801
121GSK3A0.45869250
122PRKG20.45732091
123DAPK30.45555238
124MAPKAPK20.45172910
125ILK0.44455728
126LIMK10.44238091
127PDPK10.43996144
128IRAK20.43881015
129PHKG10.43852214
130PHKG20.43852214
131MET0.43442442
132MAPK40.42972780
133SMG10.42238043
134FYN0.42184058
135PAK20.41788775
136ICK0.41759290
137PTK60.41584078
138MOS0.40178444
139PTK20.39817918
140PRKCZ0.38953027
141BMX0.38412189
142LMTK20.38213913
143DAPK20.37515151
144MAP2K60.37347658
145IKBKB0.36812249
146PRKACG0.35278931
147AURKB0.33888233
148BRSK10.31889318
149MYLK0.31498203

Predicted pathways (KEGG)

RankGene SetZ-score
1Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.98231352
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.86229610
3PPAR signaling pathway_Homo sapiens_hsa033202.68223422
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.66563023
5Fatty acid degradation_Homo sapiens_hsa000712.61678225
6Propanoate metabolism_Homo sapiens_hsa006402.60444460
7Vitamin B6 metabolism_Homo sapiens_hsa007502.47123314
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.42620176
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.41491746
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35413463
11Fatty acid metabolism_Homo sapiens_hsa012122.25944569
12Arginine biosynthesis_Homo sapiens_hsa002202.25175216
13Other glycan degradation_Homo sapiens_hsa005112.16462164
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06822651
15Pentose and glucuronate interconversions_Homo sapiens_hsa000402.03132914
16Peroxisome_Homo sapiens_hsa041461.97647182
17Fat digestion and absorption_Homo sapiens_hsa049751.97069996
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.93307515
19Tryptophan metabolism_Homo sapiens_hsa003801.91951351
20Nitrogen metabolism_Homo sapiens_hsa009101.89078123
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.88969123
22Carbon metabolism_Homo sapiens_hsa012001.84875600
23Pyruvate metabolism_Homo sapiens_hsa006201.82958907
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.80753834
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.76850169
26beta-Alanine metabolism_Homo sapiens_hsa004101.76419047
27Butanoate metabolism_Homo sapiens_hsa006501.76324768
28Complement and coagulation cascades_Homo sapiens_hsa046101.75669732
29Caffeine metabolism_Homo sapiens_hsa002321.71621456
30Folate biosynthesis_Homo sapiens_hsa007901.70524447
31Glycerolipid metabolism_Homo sapiens_hsa005611.59736701
32Fatty acid biosynthesis_Homo sapiens_hsa000611.58913207
33Biosynthesis of amino acids_Homo sapiens_hsa012301.56660350
34Sulfur relay system_Homo sapiens_hsa041221.54981074
35Pentose phosphate pathway_Homo sapiens_hsa000301.51619584
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.46454856
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.42951728
38Selenocompound metabolism_Homo sapiens_hsa004501.42607252
39Staphylococcus aureus infection_Homo sapiens_hsa051501.42241988
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.41158561
41Phenylalanine metabolism_Homo sapiens_hsa003601.37291927
42Chemical carcinogenesis_Homo sapiens_hsa052041.36602662
43Vitamin digestion and absorption_Homo sapiens_hsa049771.32999311
44Proteasome_Homo sapiens_hsa030501.30349185
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.22922472
46Glutathione metabolism_Homo sapiens_hsa004801.19689613
47Retinol metabolism_Homo sapiens_hsa008301.14295190
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.14032049
49Histidine metabolism_Homo sapiens_hsa003401.13101630
50Prion diseases_Homo sapiens_hsa050201.09867768
51Fructose and mannose metabolism_Homo sapiens_hsa000511.09668643
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08091604
53Osteoclast differentiation_Homo sapiens_hsa043801.06176808
54Starch and sucrose metabolism_Homo sapiens_hsa005001.05624498
55Tyrosine metabolism_Homo sapiens_hsa003501.05559644
56Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.02550740
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01841892
58Leishmaniasis_Homo sapiens_hsa051401.00872240
59Steroid hormone biosynthesis_Homo sapiens_hsa001400.99215063
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98601482
61Pertussis_Homo sapiens_hsa051330.96004581
62Fatty acid elongation_Homo sapiens_hsa000620.94200471
63Arginine and proline metabolism_Homo sapiens_hsa003300.87463454
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87180879
65Allograft rejection_Homo sapiens_hsa053300.83611265
66Sulfur metabolism_Homo sapiens_hsa009200.80575995
67Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78848455
68Bile secretion_Homo sapiens_hsa049760.75501688
69Viral myocarditis_Homo sapiens_hsa054160.73946787
70Vibrio cholerae infection_Homo sapiens_hsa051100.73564017
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73190851
72Graft-versus-host disease_Homo sapiens_hsa053320.70676926
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.69332508
74Galactose metabolism_Homo sapiens_hsa000520.69284334
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.68650988
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.66129573
77Autoimmune thyroid disease_Homo sapiens_hsa053200.66058919
78One carbon pool by folate_Homo sapiens_hsa006700.64474445
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64137805
80Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.63983681
81Metabolic pathways_Homo sapiens_hsa011000.61068023
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60434321
83Phagosome_Homo sapiens_hsa041450.60273894
84Tuberculosis_Homo sapiens_hsa051520.60254950
85Steroid biosynthesis_Homo sapiens_hsa001000.59245922
86Antigen processing and presentation_Homo sapiens_hsa046120.55839626
87Pyrimidine metabolism_Homo sapiens_hsa002400.54536623
88Salmonella infection_Homo sapiens_hsa051320.54119701
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53129712
90Malaria_Homo sapiens_hsa051440.52369908
91AMPK signaling pathway_Homo sapiens_hsa041520.52357323
92ABC transporters_Homo sapiens_hsa020100.50937172
93Renin-angiotensin system_Homo sapiens_hsa046140.50901713
94African trypanosomiasis_Homo sapiens_hsa051430.50622587
95Chemokine signaling pathway_Homo sapiens_hsa040620.48458151
96Collecting duct acid secretion_Homo sapiens_hsa049660.47604081
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.47201934
98Leukocyte transendothelial migration_Homo sapiens_hsa046700.47182685
99Sphingolipid metabolism_Homo sapiens_hsa006000.46294499
100Rheumatoid arthritis_Homo sapiens_hsa053230.44886320
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44088040
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.43629750
103Toxoplasmosis_Homo sapiens_hsa051450.43189108
104Hepatitis C_Homo sapiens_hsa051600.42535560
105RNA polymerase_Homo sapiens_hsa030200.42355768
106Regulation of autophagy_Homo sapiens_hsa041400.41553593
107TNF signaling pathway_Homo sapiens_hsa046680.40454586
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.40446662
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38982096
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37762224
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.37582245
112Endocytosis_Homo sapiens_hsa041440.36213931
113Insulin resistance_Homo sapiens_hsa049310.32454789
114Legionellosis_Homo sapiens_hsa051340.32180121
115Lysine degradation_Homo sapiens_hsa003100.29931517
116RNA transport_Homo sapiens_hsa030130.28589791
117Linoleic acid metabolism_Homo sapiens_hsa005910.25867696
118Lysosome_Homo sapiens_hsa041420.24737923
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24497906
120Arachidonic acid metabolism_Homo sapiens_hsa005900.20618829
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.19727930
122p53 signaling pathway_Homo sapiens_hsa041150.17911366
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.15670790
124Insulin signaling pathway_Homo sapiens_hsa049100.14957027
125Mineral absorption_Homo sapiens_hsa049780.12898313
126Glucagon signaling pathway_Homo sapiens_hsa049220.08093709
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.07866133
128Purine metabolism_Homo sapiens_hsa002300.07553099
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.07227794
130Protein digestion and absorption_Homo sapiens_hsa049740.07150463
131Bladder cancer_Homo sapiens_hsa052190.06881224
132Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.04509751

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