TMEM121

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine deoxyribonucleotide catabolic process (GO:0009223)6.67297812
2viral transcription (GO:0019083)5.69690691
3pyrimidine nucleotide catabolic process (GO:0006244)5.69063456
4pyrimidine deoxyribonucleotide metabolic process (GO:0009219)5.29393678
5translational termination (GO:0006415)5.25768410
6pattern specification involved in kidney development (GO:0061004)5.17220344
7synaptic vesicle maturation (GO:0016188)5.01919119
8DNA unwinding involved in DNA replication (GO:0006268)4.87770889
9deoxyribonucleotide catabolic process (GO:0009264)4.85710001
10peptidyl-arginine omega-N-methylation (GO:0035247)4.80684642
11translational elongation (GO:0006414)4.75931855
12mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)4.74058664
13response to pheromone (GO:0019236)4.43423776
14viral life cycle (GO:0019058)4.42509818
15ribosomal small subunit assembly (GO:0000028)4.39046493
16GDP-mannose metabolic process (GO:0019673)4.35168817
17ribosomal small subunit biogenesis (GO:0042274)4.33890485
18deoxyribose phosphate catabolic process (GO:0046386)4.33776292
19SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22790032
20deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.15636347
21positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.15276572
22peptidyl-arginine N-methylation (GO:0035246)4.12742850
23peptidyl-arginine methylation (GO:0018216)4.12742850
24protein targeting to ER (GO:0045047)4.11622842
25behavioral response to nicotine (GO:0035095)4.10341407
26cotranslational protein targeting to membrane (GO:0006613)4.10274611
27cellular protein complex disassembly (GO:0043624)4.04777784
28locomotory exploration behavior (GO:0035641)4.02809730
29nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.02604981
302-deoxyribonucleotide metabolic process (GO:0009394)3.99626826
31purine deoxyribonucleotide catabolic process (GO:0009155)3.96996468
32establishment of protein localization to endoplasmic reticulum (GO:0072599)3.94496402
33protein localization to endoplasmic reticulum (GO:0070972)3.94180851
34layer formation in cerebral cortex (GO:0021819)3.92449505
35histone arginine methylation (GO:0034969)3.88806078
36maturation of SSU-rRNA (GO:0030490)3.82934484
37protein complex disassembly (GO:0043241)3.81528047
38glutamate secretion (GO:0014047)3.80725696
39negative regulation of microtubule polymerization (GO:0031115)3.76274113
40positive regulation of catecholamine secretion (GO:0033605)3.74522287
41macromolecular complex disassembly (GO:0032984)3.70972589
42hypothalamus development (GO:0021854)3.68989159
43regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65505997
44tooth mineralization (GO:0034505)3.61065791
45pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.58793195
46metallo-sulfur cluster assembly (GO:0031163)3.58388019
47iron-sulfur cluster assembly (GO:0016226)3.58388019
48pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.57886323
49pyrimidine nucleoside monophosphate metabolic process (GO:0009129)3.57159163
50deoxyribose phosphate biosynthetic process (GO:0046385)3.54682157
512-deoxyribonucleotide biosynthetic process (GO:0009265)3.54682157
52dendritic spine morphogenesis (GO:0060997)3.52446059
53deoxyribose phosphate metabolic process (GO:0019692)3.52244413
54proline biosynthetic process (GO:0006561)3.45927935
55positive regulation of dendritic spine morphogenesis (GO:0061003)3.45869205
56regulation of monocyte differentiation (GO:0045655)3.42570335
57ncRNA 3-end processing (GO:0043628)3.40853929
58establishment of protein localization to mitochondrial membrane (GO:0090151)3.40375354
59synaptic vesicle exocytosis (GO:0016079)3.36370871
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.36033776
61central nervous system myelination (GO:0022010)3.32149531
62axon ensheathment in central nervous system (GO:0032291)3.32149531
63response to misfolded protein (GO:0051788)3.31962345
64regulation of mammary gland epithelial cell proliferation (GO:0033599)3.30148020
65guanosine-containing compound biosynthetic process (GO:1901070)3.27257077
66regulation of synaptic vesicle exocytosis (GO:2000300)3.25655869
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.25320416
68cranial nerve morphogenesis (GO:0021602)3.23828437
69negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21770277
70mitochondrion transport along microtubule (GO:0047497)3.20851483
71establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.20851483
72pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.17920339
73positive regulation of synapse maturation (GO:0090129)3.17511853
74protein retention in ER lumen (GO:0006621)3.16642896
75CTP metabolic process (GO:0046036)3.15568544
76CTP biosynthetic process (GO:0006241)3.15568544
77DNA strand elongation involved in DNA replication (GO:0006271)3.14940694
78deoxyribonucleotide metabolic process (GO:0009262)3.14781423
79protein insertion into membrane (GO:0051205)3.13874078
80mesenchymal cell differentiation involved in kidney development (GO:0072161)3.12580895
81mesenchymal cell differentiation involved in renal system development (GO:2001012)3.12580895
82histone H4-K12 acetylation (GO:0043983)3.12212303
83synaptic vesicle docking involved in exocytosis (GO:0016081)3.11716740
84translational initiation (GO:0006413)3.10334022
85exploration behavior (GO:0035640)3.08637343
86regulation of translational fidelity (GO:0006450)3.08089516
87heterochromatin organization (GO:0070828)3.07228543
88peptidyl-lysine dimethylation (GO:0018027)3.06645961
89segment specification (GO:0007379)3.06557007
90establishment of integrated proviral latency (GO:0075713)3.06555715
91UTP biosynthetic process (GO:0006228)3.04333554
92outer ear morphogenesis (GO:0042473)3.03774196
93pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.03282843
94middle ear morphogenesis (GO:0042474)3.02789702
95protein-DNA complex disassembly (GO:0032986)3.01845205
96nucleosome disassembly (GO:0006337)3.01845205
97motile cilium assembly (GO:0044458)3.01155806
98positive regulation of Notch signaling pathway (GO:0045747)3.01062801
99GTP biosynthetic process (GO:0006183)2.99869613
100negative regulation of granulocyte differentiation (GO:0030853)2.99407513
101protein localization to synapse (GO:0035418)2.97958513
102vocalization behavior (GO:0071625)2.96904499
103protein targeting to membrane (GO:0006612)2.96530898
104cell migration in hindbrain (GO:0021535)2.96281308
105purine deoxyribonucleotide metabolic process (GO:0009151)2.94191259
106regulation of glutamate receptor signaling pathway (GO:1900449)2.93041216
107pre-miRNA processing (GO:0031054)2.92550241
108mannosylation (GO:0097502)2.92248565
109auditory receptor cell differentiation (GO:0042491)2.91794792
110negative regulation of RNA splicing (GO:0033119)2.90869106
111aldehyde catabolic process (GO:0046185)2.89522714
112DNA strand elongation (GO:0022616)2.89399267
113negative regulation of norepinephrine secretion (GO:0010700)2.89111324
114protein maturation by protein folding (GO:0022417)2.87999607
115negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.87160302
116parturition (GO:0007567)2.86898080
117UTP metabolic process (GO:0046051)2.85438865
118mammary gland epithelial cell differentiation (GO:0060644)2.83895781
119intracellular estrogen receptor signaling pathway (GO:0030520)2.83647139
120establishment of mitochondrion localization (GO:0051654)2.80781678
121pyrimidine nucleotide metabolic process (GO:0006220)2.78736568
122respiratory system process (GO:0003016)2.77811898
123negative regulation of histone methylation (GO:0031061)2.77238454
124mesenchymal to epithelial transition (GO:0060231)2.76923874
125nucleobase-containing small molecule interconversion (GO:0015949)2.76323032
126ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.76251104
127dendritic spine organization (GO:0097061)2.76134261
128negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.75731227
129regulation of synapse structural plasticity (GO:0051823)2.74811091
130positive regulation of dendritic spine development (GO:0060999)2.74536795
131neurotransmitter secretion (GO:0007269)2.73707045
132regulation of respiratory system process (GO:0044065)2.72458982
133maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.72394551
134glial cell proliferation (GO:0014009)2.71436790
135microtubule severing (GO:0051013)2.71400525
136negative regulation of DNA-templated transcription, elongation (GO:0032785)2.71279853
137regulation of neuronal synaptic plasticity (GO:0048168)2.70925126
138protein complex localization (GO:0031503)2.70847993
139spliceosomal tri-snRNP complex assembly (GO:0000244)2.70042038
140base-excision repair, AP site formation (GO:0006285)2.69382260
141regulation of glucocorticoid secretion (GO:2000849)2.68530540
142dosage compensation (GO:0007549)2.67145526
143amyloid precursor protein catabolic process (GO:0042987)2.66482336
144DNA replication initiation (GO:0006270)2.65804065
145nuclear-transcribed mRNA catabolic process (GO:0000956)2.63539300
146positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.62588551
147neuromuscular process controlling balance (GO:0050885)2.60908452
148regulation of DNA damage checkpoint (GO:2000001)2.59549831
149positive regulation of cell cycle G2/M phase transition (GO:1902751)2.59287465
150positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.59287465
151folic acid-containing compound biosynthetic process (GO:0009396)2.57983887
152regulation of long-term neuronal synaptic plasticity (GO:0048169)2.57317712
153adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.57254417
154sodium ion export (GO:0071436)2.57215699
155G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.56619126
156neuron cell-cell adhesion (GO:0007158)2.56599666
157regulation of synaptic vesicle transport (GO:1902803)2.55484982
158positive regulation of dendrite morphogenesis (GO:0050775)2.54289421
159DNA duplex unwinding (GO:0032508)2.54224061
160negative regulation of mRNA processing (GO:0050686)2.53464012
161regulation of protein heterodimerization activity (GO:0043497)2.53106357
162cell communication by electrical coupling (GO:0010644)2.51938210
163regulation of translational termination (GO:0006449)2.51624849
164negative regulation of cell size (GO:0045792)2.50570341
165cerebellar Purkinje cell layer development (GO:0021680)2.50349843
166mitotic G1 DNA damage checkpoint (GO:0031571)2.50314172
167DNA geometric change (GO:0032392)2.49281506
168glucocorticoid receptor signaling pathway (GO:0042921)2.46250801
169regulation of dendritic spine morphogenesis (GO:0061001)2.45019157
170clathrin coat assembly (GO:0048268)2.44177047
171peptidyl-arginine modification (GO:0018195)2.43791924
172proline transport (GO:0015824)2.43559634
173negative regulation of organelle assembly (GO:1902116)2.43443985
174cerebellum development (GO:0021549)2.42834283
175dendrite morphogenesis (GO:0048813)2.41519329
176telomere maintenance via semi-conservative replication (GO:0032201)2.40726477
177maternal placenta development (GO:0001893)2.38440348
178negative regulation of telomerase activity (GO:0051974)2.38343276
179translesion synthesis (GO:0019985)2.34614887
180sister chromatid segregation (GO:0000819)2.32098013
181protein localization to kinetochore (GO:0034501)2.31989578
182deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.31680913
183dopamine receptor signaling pathway (GO:0007212)2.30976019
184regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29703954
185negative regulation of mRNA metabolic process (GO:1903312)2.29529943
186DNA replication-dependent nucleosome assembly (GO:0006335)2.29436296
187DNA replication-dependent nucleosome organization (GO:0034723)2.29436296
188positive regulation of nitric-oxide synthase activity (GO:0051000)2.28716282
189neuromuscular process controlling posture (GO:0050884)2.28171757
190regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.28138187
191postreplication repair (GO:0006301)2.28047151
192postsynaptic membrane organization (GO:0001941)2.27343953

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.02352736
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.33511063
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.02136960
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.01652650
5ZFP281_18757296_ChIP-ChIP_E14_Mouse2.85312996
6MYC_22102868_ChIP-Seq_BL_Human2.83849946
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.74953207
8EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.71369577
9MYC_18555785_ChIP-Seq_MESCs_Mouse2.70765550
10EZH2_22144423_ChIP-Seq_EOC_Human2.52049911
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44432200
12THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27726261
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16906176
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.14877015
15KDM2B_26808549_Chip-Seq_DND41_Human2.02414049
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99083416
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98521482
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96865118
19RARB_27405468_Chip-Seq_BRAIN_Mouse1.96412522
20ZFP281_27345836_Chip-Seq_ESCs_Mouse1.93329838
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.86716655
22CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.86268184
23CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.85893440
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.82571514
25* LXR_22292898_ChIP-Seq_THP-1_Human1.82471600
26XRN2_22483619_ChIP-Seq_HELA_Human1.80020078
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79548911
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.76244366
29CIITA_25753668_ChIP-Seq_RAJI_Human1.75506415
30CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.74626897
31* SA1_27219007_Chip-Seq_ERYTHROID_Human1.73434485
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.72975118
33VDR_21846776_ChIP-Seq_THP-1_Human1.71802277
34E2F4_17652178_ChIP-ChIP_JURKAT_Human1.70792071
35POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.69329685
36RNF2_18974828_ChIP-Seq_MESCs_Mouse1.67978411
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.67978411
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67705299
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.66144958
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64549634
41TP53_20018659_ChIP-ChIP_R1E_Mouse1.63631246
42* EZH2_27294783_Chip-Seq_ESCs_Mouse1.63336011
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.62311949
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.60637849
45* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60520453
46SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60049908
47MYC_19030024_ChIP-ChIP_MESCs_Mouse1.59950703
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.57470219
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.56043286
50ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54444473
51CTCF_27219007_Chip-Seq_Bcells_Human1.53845846
52SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.52966835
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50384764
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.50061225
55* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.49820009
56TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49547098
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49402993
58* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.49263101
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.47338897
60REST_18959480_ChIP-ChIP_MESCs_Mouse1.47276877
61NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47080489
62* KDM2B_26808549_Chip-Seq_K562_Human1.46792886
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.46191411
64BCL6_27268052_Chip-Seq_Bcells_Human1.45292546
65SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44609701
66* TCF7_22412390_ChIP-Seq_EML_Mouse1.43882618
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.43574337
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.42117670
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.41775415
70* REST_21632747_ChIP-Seq_MESCs_Mouse1.41677197
71* CTCF_26484167_Chip-Seq_Bcells_Mouse1.40987635
72SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40493566
73ERG_21242973_ChIP-ChIP_JURKAT_Human1.39388324
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.39250976
75KDM2B_26808549_Chip-Seq_JURKAT_Human1.37642411
76SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36356789
77RNF2_27304074_Chip-Seq_ESCs_Mouse1.36172770
78* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35960050
79MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.35916401
80* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35666889
81ZNF263_19887448_ChIP-Seq_K562_Human1.34679779
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34453106
83* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34304344
84CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32883284
85FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.31061444
86YY1_21170310_ChIP-Seq_MESCs_Mouse1.29938794
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28948335
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.28516219
89RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27399778
90ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.26286498
91CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.25480248
92SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.24965503
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.24754617
94* MAF_26560356_Chip-Seq_TH2_Human1.23899783
95KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.23850517
96KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23583254
97RARA_24833708_ChIP-Seq_LIVER_Mouse1.22742243
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.22201510
99SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22003702
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21759435
101* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21215484
102* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20429881
103* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.20054863
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18822862
105SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17410951
106SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.16451343
107E2F1_20622854_ChIP-Seq_HELA_Human1.15728582
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.15649944
109KDM5A_27292631_Chip-Seq_BREAST_Human1.15146882
110* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.14846139
111* CREB1_26743006_Chip-Seq_LNCaP_Human1.14582479
112RARB_24833708_ChIP-Seq_LIVER_Mouse1.14452034
113* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14160206
114ELF1_17652178_ChIP-ChIP_JURKAT_Human1.14041843
115ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13552706
116CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.13346719
117* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13263421
118PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13217927
119NANOG_21062744_ChIP-ChIP_HESCs_Human1.11919555
120ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11394699
121CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.11326544
122PHF8_20622854_ChIP-Seq_HELA_Human1.09512713
123MYCN_18555785_ChIP-Seq_MESCs_Mouse1.09364823
124CTCF_20526341_ChIP-Seq_ESCs_Human1.08885834
125STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.08550745
126TTF2_22483619_ChIP-Seq_HELA_Human1.07362665
127P68_20966046_ChIP-Seq_HELA_Human1.06363138
128* CTCF_21964334_Chip-Seq_Bcells_Human1.05969043
129POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04602109
130RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.04177918
131DROSHA_22980978_ChIP-Seq_HELA_Human1.03840591
132POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.02603527
133NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02429661
134TET1_21451524_ChIP-Seq_MESCs_Mouse1.02124381
135CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01989616
136ETS1_20019798_ChIP-Seq_JURKAT_Human1.01695758
137ELF1_20517297_ChIP-Seq_JURKAT_Human1.01410674
138UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.00728835
139NELFA_20434984_ChIP-Seq_ESCs_Mouse1.00365499
140NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00143345
141NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99904252
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.99691447
143* RACK7_27058665_Chip-Seq_MCF-7_Human0.99107650
144GABP_19822575_ChIP-Seq_HepG2_Human0.98822539
145TP53_22127205_ChIP-Seq_IMR90_Human0.97136239
146SMC4_20622854_ChIP-Seq_HELA_Human0.96533012
147MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95997159
148TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95815021
149IKZF1_21737484_ChIP-ChIP_HCT116_Human0.95556900

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.08578421
2MP0002249_abnormal_larynx_morphology3.48195801
3MP0003635_abnormal_synaptic_transmissio2.83888723
4MP0004858_abnormal_nervous_system2.72505213
5MP0009780_abnormal_chondrocyte_physiolo2.53187670
6MP0002653_abnormal_ependyma_morphology2.52612073
7MP0000681_abnormal_thyroid_gland2.50529845
8MP0009379_abnormal_foot_pigmentation2.43695732
9MP0002063_abnormal_learning/memory/cond2.31427780
10MP0006292_abnormal_olfactory_placode2.26764675
11MP0006276_abnormal_autonomic_nervous2.22468045
12MP0004270_analgesia2.21491971
13MP0004742_abnormal_vestibular_system2.19511537
14MP0000049_abnormal_middle_ear2.19502555
15MP0003283_abnormal_digestive_organ2.19215780
16MP0002234_abnormal_pharynx_morphology2.18564243
17MP0002160_abnormal_reproductive_system2.10732470
18MP0001968_abnormal_touch/_nociception2.04667420
19MP0000678_abnormal_parathyroid_gland1.99198805
20MP0003123_paternal_imprinting1.77729903
21MP0010094_abnormal_chromosome_stability1.77378483
22MP0004811_abnormal_neuron_physiology1.76858359
23MP0004133_heterotaxia1.73396884
24MP0002733_abnormal_thermal_nociception1.72056440
25MP0001529_abnormal_vocalization1.72038982
26MP0010352_gastrointestinal_tract_polyps1.69652222
27MP0010030_abnormal_orbit_morphology1.69468092
28MP0003111_abnormal_nucleus_morphology1.65986541
29MP0003880_abnormal_central_pattern1.65924714
30MP0004957_abnormal_blastocyst_morpholog1.65144902
31MP0000778_abnormal_nervous_system1.64581923
32MP0003122_maternal_imprinting1.63279934
33MP0000955_abnormal_spinal_cord1.62012670
34MP0002064_seizures1.61892064
35MP0005423_abnormal_somatic_nervous1.59624839
36MP0004782_abnormal_surfactant_physiolog1.59368864
37MP0002572_abnormal_emotion/affect_behav1.58186382
38MP0009745_abnormal_behavioral_response1.57999274
39MP0001730_embryonic_growth_arrest1.57104504
40MP0001348_abnormal_lacrimal_gland1.57011670
41MP0002736_abnormal_nociception_after1.55719396
42MP0000537_abnormal_urethra_morphology1.53006696
43MP0003119_abnormal_digestive_system1.52591392
44MP0003942_abnormal_urinary_system1.52021994
45MP0002909_abnormal_adrenal_gland1.51077365
46MP0005389_reproductive_system_phenotype1.48141212
47MP0002184_abnormal_innervation1.47238418
48MP0008961_abnormal_basal_metabolism1.46807613
49MP0005187_abnormal_penis_morphology1.44766236
50MP0002557_abnormal_social/conspecific_i1.44085264
51MP0003861_abnormal_nervous_system1.43290384
52MP0003077_abnormal_cell_cycle1.42818160
53MP0004233_abnormal_muscle_weight1.42766548
54MP0002734_abnormal_mechanical_nocicepti1.42256652
55MP0003329_amyloid_beta_deposits1.40878487
56MP0003879_abnormal_hair_cell1.40692077
57MP0005397_hematopoietic_system_phenotyp1.40536335
58MP0001545_abnormal_hematopoietic_system1.40536335
59MP0000631_abnormal_neuroendocrine_gland1.39102317
60MP0005646_abnormal_pituitary_gland1.39080520
61MP0002089_abnormal_postnatal_growth/wei1.38550446
62MP0002932_abnormal_joint_morphology1.36186841
63MP0008569_lethality_at_weaning1.35781106
64MP0003705_abnormal_hypodermis_morpholog1.34926701
65MP0005499_abnormal_olfactory_system1.33264172
66MP0005394_taste/olfaction_phenotype1.33264172
67MP0009278_abnormal_bone_marrow1.31170799
68MP0000350_abnormal_cell_proliferation1.31147379
69MP0001970_abnormal_pain_threshold1.29632099
70MP0002152_abnormal_brain_morphology1.29557486
71MP0001502_abnormal_circadian_rhythm1.27833406
72MP0005076_abnormal_cell_differentiation1.27056902
73MP0002084_abnormal_developmental_patter1.26874517
74MP0008007_abnormal_cellular_replicative1.26592376
75MP0001486_abnormal_startle_reflex1.26070722
76MP0002822_catalepsy1.23077217
77MP0005623_abnormal_meninges_morphology1.22464100
78MP0002085_abnormal_embryonic_tissue1.19716884
79MP0005645_abnormal_hypothalamus_physiol1.18850468
80MP0005075_abnormal_melanosome_morpholog1.17123255
81MP0008932_abnormal_embryonic_tissue1.16992649
82MP0005508_abnormal_skeleton_morphology1.15987297
83MP0002882_abnormal_neuron_morphology1.14468211
84MP0002751_abnormal_autonomic_nervous1.14070681
85MP0003121_genomic_imprinting1.13272649
86MP0000372_irregular_coat_pigmentation1.12879981
87MP0009250_abnormal_appendicular_skeleto1.12044865
88MP0003890_abnormal_embryonic-extraembry1.11547889
89MP0009046_muscle_twitch1.11455978
90MP0009672_abnormal_birth_weight1.10752265
91MP0001340_abnormal_eyelid_morphology1.10488136
92MP0001984_abnormal_olfaction1.09876049
93MP0001905_abnormal_dopamine_level1.09720897
94MP0008877_abnormal_DNA_methylation1.07165284
95MP0001963_abnormal_hearing_physiology1.04180786
96MP0000026_abnormal_inner_ear1.03963184
97MP0004197_abnormal_fetal_growth/weight/1.03254721
98MP0008789_abnormal_olfactory_epithelium1.02789736
99MP0001849_ear_inflammation1.02638727
100MP0002272_abnormal_nervous_system1.01917397
101MP0002080_prenatal_lethality1.01252588
102MP0003693_abnormal_embryo_hatching1.00494269
103MP0001697_abnormal_embryo_size0.99474558
104MP0002116_abnormal_craniofacial_bone0.98660455
105MP0002877_abnormal_melanocyte_morpholog0.98257881
106MP0002752_abnormal_somatic_nervous0.97955525
107MP0009333_abnormal_splenocyte_physiolog0.97366126
108MP0010307_abnormal_tumor_latency0.96448952
109MP0002938_white_spotting0.96165330
110MP0002066_abnormal_motor_capabilities/c0.96043443
111MP0004130_abnormal_muscle_cell0.95646672
112MP0001440_abnormal_grooming_behavior0.95628664
113MP0004808_abnormal_hematopoietic_stem0.94654459
114MP0002067_abnormal_sensory_capabilities0.93938619
115MP0004885_abnormal_endolymph0.93423249
116MP0008770_decreased_survivor_rate0.92128003
117MP0000462_abnormal_digestive_system0.91835727
118MP0002638_abnormal_pupillary_reflex0.91165130
119MP0001919_abnormal_reproductive_system0.90783444
120MP0002092_abnormal_eye_morphology0.90369741
121MP0002081_perinatal_lethality0.88711649
122MP0002697_abnormal_eye_size0.88303923
123MP0004924_abnormal_behavior0.88219058
124MP0005386_behavior/neurological_phenoty0.88219058
125MP0003787_abnormal_imprinting0.87163239
126MP0001293_anophthalmia0.85619668
127MP0002282_abnormal_trachea_morphology0.85391921
128MP0003634_abnormal_glial_cell0.85288994
129MP0000534_abnormal_ureter_morphology0.85026733
130MP0002735_abnormal_chemical_nociception0.84599633
131MP0003315_abnormal_perineum_morphology0.83657963
132MP0001672_abnormal_embryogenesis/_devel0.83101956
133MP0005380_embryogenesis_phenotype0.83101956
134MP0002177_abnormal_outer_ear0.82436684
135MP0001346_abnormal_lacrimal_gland0.82355459
136MP0000703_abnormal_thymus_morphology0.81757855
137MP0004142_abnormal_muscle_tone0.81340257
138MP0009384_cardiac_valve_regurgitation0.81298481
139MP0000428_abnormal_craniofacial_morphol0.81204619
140MP0001881_abnormal_mammary_gland0.80057268
141MP0010769_abnormal_survival0.79511782
142MP0009703_decreased_birth_body0.78836691
143MP0010768_mortality/aging0.77296429
144MP0002075_abnormal_coat/hair_pigmentati0.76502114
145MP0004185_abnormal_adipocyte_glucose0.75338109
146MP0002082_postnatal_lethality0.73479412
147MP0010770_preweaning_lethality0.73479412
148MP0001727_abnormal_embryo_implantation0.73347350
149MP0003137_abnormal_impulse_conducting0.70337313
150MP0002114_abnormal_axial_skeleton0.69832932
151MP0001188_hyperpigmentation0.66262176
152MP0005195_abnormal_posterior_eye0.62498934
153MP0000538_abnormal_urinary_bladder0.61840565

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)3.84695574
2Absent rod-and cone-mediated responses on ERG (HP:0007688)3.70014383
3Abnormality of cochlea (HP:0000375)3.67738580
4Hyperacusis (HP:0010780)3.58321950
5Retinal dysplasia (HP:0007973)3.49907499
6Reticulocytopenia (HP:0001896)3.47674553
7Elevated erythrocyte sedimentation rate (HP:0003565)3.43059528
8Enlarged penis (HP:0000040)3.33270247
9Megalencephaly (HP:0001355)3.26610264
10Ependymoma (HP:0002888)3.24170222
11Insomnia (HP:0100785)3.12861880
12Morphological abnormality of the inner ear (HP:0011390)3.12604743
13Abnormality of the astrocytes (HP:0100707)3.09963322
14Astrocytoma (HP:0009592)3.09963322
15Failure to thrive in infancy (HP:0001531)3.05986981
16Macroorchidism (HP:0000053)3.04212294
17Type II lissencephaly (HP:0007260)3.02969398
18Ankyloglossia (HP:0010296)2.98278857
19Pointed chin (HP:0000307)2.92541187
20Hyperthyroidism (HP:0000836)2.91450993
21Optic nerve coloboma (HP:0000588)2.91148571
22Down-sloping shoulders (HP:0200021)2.91099871
23Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90872353
24Renal duplication (HP:0000075)2.85184210
25Abnormality of the lower motor neuron (HP:0002366)2.83840470
26Papilledema (HP:0001085)2.77682765
27Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.74471720
28Visual hallucinations (HP:0002367)2.73604721
29Overriding aorta (HP:0002623)2.73171384
30Short femoral neck (HP:0100864)2.71561738
31Hypoplastic pelvis (HP:0008839)2.70847560
32Abnormality of cells of the erythroid lineage (HP:0012130)2.69677229
33Bowel diverticulosis (HP:0005222)2.67453661
34Amyotrophic lateral sclerosis (HP:0007354)2.64941707
35Polyphagia (HP:0002591)2.63338917
36Broad distal phalanx of finger (HP:0009836)2.61613759
37Supranuclear gaze palsy (HP:0000605)2.52681001
38Annular pancreas (HP:0001734)2.49896028
39Abnormality of oral frenula (HP:0000190)2.49781596
40Ankle clonus (HP:0011448)2.48598641
41Hepatocellular necrosis (HP:0001404)2.47113123
42Increased muscle lipid content (HP:0009058)2.45007968
43Chronic hepatic failure (HP:0100626)2.43720151
44Elfin facies (HP:0004428)2.41767231
45Sclerocornea (HP:0000647)2.39736517
46Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.35495031
47Megalocornea (HP:0000485)2.32378177
48Hepatic necrosis (HP:0002605)2.31729066
49Hypercortisolism (HP:0001578)2.30897476
50Double outlet right ventricle (HP:0001719)2.30088577
51Congenital malformation of the right heart (HP:0011723)2.30088577
52Atelectasis (HP:0100750)2.29672381
53Colon cancer (HP:0003003)2.29269333
54Cerebral hypomyelination (HP:0006808)2.27721711
55Ragged-red muscle fibers (HP:0003200)2.27540013
56Genu recurvatum (HP:0002816)2.22438602
57Renovascular hypertension (HP:0100817)2.22174259
58Stridor (HP:0010307)2.20883101
59Focal seizures (HP:0007359)2.17436296
60Increased intramyocellular lipid droplets (HP:0012240)2.16302473
61Large eyes (HP:0001090)2.15278327
62Abnormal number of erythroid precursors (HP:0012131)2.14187521
63Abnormality of the labia minora (HP:0012880)2.13762822
64Deep palmar crease (HP:0006191)2.13033263
65Neoplasm of the heart (HP:0100544)2.12714964
66Microretrognathia (HP:0000308)2.12245397
67Atrophy/Degeneration involving motor neurons (HP:0007373)2.11555625
68Adenoma sebaceum (HP:0009720)2.11231555
69Angiofibromas (HP:0010615)2.11231555
70Glioma (HP:0009733)2.09492015
71Increased nuchal translucency (HP:0010880)2.08086412
72Facial hemangioma (HP:0000329)2.06241337
73Premature skin wrinkling (HP:0100678)2.05359372
74Radial bowing (HP:0002986)2.05073919
75Hypoplastic left heart (HP:0004383)2.05000446
76Self-mutilation (HP:0000742)2.04252126
77Urinary urgency (HP:0000012)2.04119965
78Progressive microcephaly (HP:0000253)2.02304049
79Achilles tendon contracture (HP:0001771)2.01273886
80Abnormal eating behavior (HP:0100738)2.01034250
81Ulnar claw (HP:0001178)2.00913838
82Increased variability in muscle fiber diameter (HP:0003557)2.00345755
83Poor eye contact (HP:0000817)2.00298093
84Depression (HP:0000716)2.00217405
85Impaired vibration sensation in the lower limbs (HP:0002166)2.00142004
86Aplasia/hypoplasia of the femur (HP:0005613)1.99248262
87Flat cornea (HP:0007720)1.99103466
88Sacral dimple (HP:0000960)1.98453093
89Occipital encephalocele (HP:0002085)1.97983923
90Abnormality of the aortic arch (HP:0012303)1.97299989
91Attention deficit hyperactivity disorder (HP:0007018)1.94088712
92Shoulder girdle muscle weakness (HP:0003547)1.93432647
93Bowing of the arm (HP:0006488)1.92172228
94Bowed forearm bones (HP:0003956)1.92172228
95Apathy (HP:0000741)1.91836422
96Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.91391565
97Pulmonary artery stenosis (HP:0004415)1.91325414
98Macrocytic anemia (HP:0001972)1.90753665
99Diminished motivation (HP:0000745)1.88628463
100Molar tooth sign on MRI (HP:0002419)1.88476530
101Abnormality of midbrain morphology (HP:0002418)1.88476530
102Intellectual disability, profound (HP:0002187)1.87723221
103Maternal diabetes (HP:0009800)1.87243563
104Impaired smooth pursuit (HP:0007772)1.87015118
105Pallor (HP:0000980)1.86835217
106Keratoconus (HP:0000563)1.86824821
107Increased corneal curvature (HP:0100692)1.86824821
108Short 4th metacarpal (HP:0010044)1.86339910
109Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.86339910
110Epileptic encephalopathy (HP:0200134)1.86214912
111Turricephaly (HP:0000262)1.85035658
112Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.83454394
113Absent epiphyses (HP:0010577)1.83454394
114Rib fusion (HP:0000902)1.83416152
115Overlapping toe (HP:0001845)1.83230374
116Asplenia (HP:0001746)1.82927674
117High anterior hairline (HP:0009890)1.82870853
118Mitochondrial inheritance (HP:0001427)1.81859232
119Obsessive-compulsive behavior (HP:0000722)1.81706860
120Hypercalcemia (HP:0003072)1.81662035
121Missing ribs (HP:0000921)1.80873599
122Acute lymphatic leukemia (HP:0006721)1.80541203
123Neoplasm of striated muscle (HP:0009728)1.79518889
124Bladder diverticulum (HP:0000015)1.79466402
125Fibroma (HP:0010614)1.79398240
126Transposition of the great arteries (HP:0001669)1.79279498
127Abnormal connection of the cardiac segments (HP:0011545)1.79279498
128Abnormal ventriculo-arterial connection (HP:0011563)1.79279498
129Abnormal rod and cone electroretinograms (HP:0008323)1.78820019
130Generalized hypotonia (HP:0001290)1.78681960
131Aplasia/Hypoplasia of the patella (HP:0006498)1.78494632
132Adducted thumb (HP:0001181)1.77976338
133Broad alveolar ridges (HP:0000187)1.77888990
134Abnormality of the diencephalon (HP:0010662)1.77078136
135Spastic gait (HP:0002064)1.76272821
136Agitation (HP:0000713)1.76051698
137Patellar aplasia (HP:0006443)1.75970514
138Hemiplegia (HP:0002301)1.75950210
139Congenital hip dislocation (HP:0001374)1.74893804
140Abnormal mitochondria in muscle tissue (HP:0008316)1.74843582
141Mild short stature (HP:0003502)1.74543629
14211 pairs of ribs (HP:0000878)1.74182061
143Hallux valgus (HP:0001822)1.74037994
144Neoplasm of the oral cavity (HP:0100649)1.73954751
145Duplication of thumb phalanx (HP:0009942)1.73635645
146Precocious puberty (HP:0000826)1.72916057
147Aplasia/Hypoplasia of the spleen (HP:0010451)1.72753850
148Abnormal number of incisors (HP:0011064)1.72473347
149Rectal prolapse (HP:0002035)1.72406379
150Myopathic facies (HP:0002058)1.71931622
151Meningocele (HP:0002435)1.71844957
152Action tremor (HP:0002345)1.71634859
153Shallow orbits (HP:0000586)1.70400852
154Fibrous tissue neoplasm (HP:0012316)1.69640742
155Anterior segment dysgenesis (HP:0007700)1.69595873
156Hip dysplasia (HP:0001385)1.68960672
157Deviation of the hallux (HP:0010051)1.68874162
158Obstructive sleep apnea (HP:0002870)1.68797585
159Upper motor neuron abnormality (HP:0002127)1.68208582
160Truncal ataxia (HP:0002078)1.68048942
161Growth hormone excess (HP:0000845)1.67499190
162Decreased central vision (HP:0007663)1.67185398
163Anomalous pulmonary venous return (HP:0010772)1.67159716
164Cerebral inclusion bodies (HP:0100314)1.66880083
165Amelogenesis imperfecta (HP:0000705)1.66823711
166Lissencephaly (HP:0001339)1.65699057
167Aplasia/Hypoplasia of the brainstem (HP:0007362)1.65529055
168Hypoplasia of the brainstem (HP:0002365)1.65529055
169Pelvic girdle muscle weakness (HP:0003749)1.65335253
170Torticollis (HP:0000473)1.65326245
171Hand muscle atrophy (HP:0009130)1.65143610
172Urinary bladder sphincter dysfunction (HP:0002839)1.65076893
173Aggressive behavior (HP:0000718)1.64023053
174Selective tooth agenesis (HP:0001592)1.63695760
175Broad palm (HP:0001169)1.62787343
176Limb dystonia (HP:0002451)1.62507125
177Medulloblastoma (HP:0002885)1.62402966
178Emotional lability (HP:0000712)1.62199480
179Hypergonadotropic hypogonadism (HP:0000815)1.62155812
180Truncus arteriosus (HP:0001660)1.61637119
181Abnormality of the Achilles tendon (HP:0005109)1.61627833
182Abnormal social behavior (HP:0012433)1.61172662
183Impaired social interactions (HP:0000735)1.61172662
184Pseudobulbar signs (HP:0002200)1.61163113
185Hypoventilation (HP:0002791)1.61032543
186Long foot (HP:0001833)1.60408638
187Abnormality of the hip-girdle musculature (HP:0001445)1.60149670
188Abnormality of the musculature of the pelvis (HP:0001469)1.60149670

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.80431548
2SMG13.61357875
3EEF2K3.59095307
4BCKDK3.55120357
5MARK13.04600752
6TRIB32.94579554
7ARAF2.93886096
8MAP3K92.88201504
9NME22.74959943
10SIK12.65051922
11MAP3K102.61067083
12TESK22.47742354
13SCYL22.47723166
14PKN22.38114440
15CDC72.30866604
16MAPK152.25918340
17NTRK22.19622247
18UHMK12.17505034
19MINK12.16661342
20TYRO32.07354135
21NTRK32.04552330
22MAP4K22.02623612
23PIM21.95674428
24ERN11.90146151
25KSR11.89320153
26PAK61.87426083
27PRKD31.86959528
28LATS21.83486240
29SIK21.81556510
30TAF11.81235150
31STK161.80098599
32EPHB21.79999680
33ICK1.77148123
34DAPK11.74846581
35NEK11.65886588
36CDK191.62925472
37KSR21.59064826
38NME11.48194392
39ALK1.39818155
40CDK181.39541391
41TNK21.39425447
42DAPK21.37723385
43CDK151.37158971
44EPHA41.36141928
45LIMK11.35507967
46TAOK11.35502253
47CDK141.32783461
48PASK1.32074895
49CDK11A1.30406637
50CDK81.30366566
51CAMKK11.24131928
52BRSK11.21249625
53IRAK31.20891393
54PDGFRA1.20695858
55RPS6KL11.19553806
56RPS6KC11.19553806
57GRK51.17072373
58BRAF1.13798849
59CSNK1G31.13642059
60RPS6KA61.07792456
61MAP3K111.07675370
62LRRK21.04360773
63PRKD21.03502100
64RPS6KB21.03318827
65NTRK11.00899571
66BUB11.00692218
67CAMK1D1.00248490
68SIK31.00024118
69ABL20.97958482
70TESK10.97374148
71MAPKAPK30.95931820
72KDR0.95327286
73EPHA20.95181500
74GRK60.94311829
75FGFR20.93401010
76CSNK1A1L0.91013076
77CDK50.89665769
78AURKA0.89023755
79CSNK1G20.88779324
80MAP2K20.87981593
81HIPK20.82713916
82CDK120.81338150
83DDR20.79033768
84MAPK130.78554284
85PHKG10.77146057
86PHKG20.77146057
87MARK20.76341973
88MAP3K120.73791728
89PTK60.72394594
90BMX0.71881126
91NEK20.71259575
92RET0.70411443
93MAPKAPK50.69655857
94CDK70.69181888
95VRK10.67319891
96LMTK20.66902233
97MAP3K40.66726710
98DYRK30.63684990
99CDK20.61607647
100DYRK20.60411932
101ILK0.59958074
102MAPK40.59527877
103WEE10.57257135
104RPS6KA20.56336286
105CAMK2G0.56035671
106PRKCG0.55953727
107CSNK1G10.55129213
108STK110.54283003
109DYRK1A0.53774106
110PAK10.52896390
111CAMK2B0.52494459
112MTOR0.51113469
113TSSK60.49838757
114PAK30.48917708
115ATR0.48154879
116CCNB10.47940537
117CHEK10.46397745
118RPS6KA50.46322906
119FGFR10.44977370
120AKT20.44867388
121MAP3K80.44475221
122MAPK90.44152404
123MAPK110.42819421
124CDK40.42547236
125PAK40.42521783
126DYRK1B0.42328970
127PLK10.41938796
128CSNK1E0.41448051
129TGFBR10.41330806
130PRKCZ0.40906514
131CAMK1G0.40466655
132MAP3K130.40394185
133PRPF4B0.39581148
134PKN10.39415335
135MAP3K10.38185622
136CDK90.37685663
137LATS10.37525318
138MAP2K40.37235483
139IRAK20.36399579
140MAPK100.35549338
141MUSK0.35267273
142PRKCH0.35216334
143CDK10.34883126
144DAPK30.34108097
145FES0.33767931
146CHEK20.32561876
147CAMK10.32311232
148TLK10.32270732
149ERBB30.31887682
150MATK0.31133060
151RPS6KA10.30555277
152PRKCI0.29140413

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041226.28890415
2DNA replication_Homo sapiens_hsa030302.77578679
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.47111215
4Pyrimidine metabolism_Homo sapiens_hsa002402.40670477
5Mismatch repair_Homo sapiens_hsa034302.26123906
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.17188255
7Synaptic vesicle cycle_Homo sapiens_hsa047212.10757613
8RNA polymerase_Homo sapiens_hsa030202.01716069
9Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.96434564
10Spliceosome_Homo sapiens_hsa030401.83906366
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82937386
12Vitamin B6 metabolism_Homo sapiens_hsa007501.77689362
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.69285845
14Base excision repair_Homo sapiens_hsa034101.67199471
15Dopaminergic synapse_Homo sapiens_hsa047281.66304657
16Glioma_Homo sapiens_hsa052141.61075372
17Long-term potentiation_Homo sapiens_hsa047201.57049460
18Oocyte meiosis_Homo sapiens_hsa041141.53842012
19N-Glycan biosynthesis_Homo sapiens_hsa005101.53517960
20Olfactory transduction_Homo sapiens_hsa047401.50813113
21Folate biosynthesis_Homo sapiens_hsa007901.50282121
22mRNA surveillance pathway_Homo sapiens_hsa030151.46552045
23Colorectal cancer_Homo sapiens_hsa052101.44079345
24Amphetamine addiction_Homo sapiens_hsa050311.42934238
25Circadian entrainment_Homo sapiens_hsa047131.39677524
26RNA transport_Homo sapiens_hsa030131.37800168
27Nicotine addiction_Homo sapiens_hsa050331.37241969
28Cell cycle_Homo sapiens_hsa041101.35613850
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.33550200
30Estrogen signaling pathway_Homo sapiens_hsa049151.31186617
31GABAergic synapse_Homo sapiens_hsa047271.31130147
32Gap junction_Homo sapiens_hsa045401.30216254
33Non-small cell lung cancer_Homo sapiens_hsa052231.30184026
34Cholinergic synapse_Homo sapiens_hsa047251.29377034
35Glutamatergic synapse_Homo sapiens_hsa047241.29302690
36Cocaine addiction_Homo sapiens_hsa050301.26633454
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26433724
38Neurotrophin signaling pathway_Homo sapiens_hsa047221.26280352
39Alcoholism_Homo sapiens_hsa050341.25616901
40mTOR signaling pathway_Homo sapiens_hsa041501.25125515
41ErbB signaling pathway_Homo sapiens_hsa040121.23767852
42Morphine addiction_Homo sapiens_hsa050321.22693626
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21821869
44Endometrial cancer_Homo sapiens_hsa052131.19789130
45Insulin secretion_Homo sapiens_hsa049111.18409335
46Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16884094
47Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16403357
48Hippo signaling pathway_Homo sapiens_hsa043901.15884636
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.15152694
50Chronic myeloid leukemia_Homo sapiens_hsa052201.14501011
51Oxidative phosphorylation_Homo sapiens_hsa001901.14378025
52Basal cell carcinoma_Homo sapiens_hsa052171.12099392
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.09904020
54Cardiac muscle contraction_Homo sapiens_hsa042601.09389990
55VEGF signaling pathway_Homo sapiens_hsa043701.08728449
56Melanogenesis_Homo sapiens_hsa049161.08477938
57Central carbon metabolism in cancer_Homo sapiens_hsa052301.06196187
58Biosynthesis of amino acids_Homo sapiens_hsa012301.05635208
59Fanconi anemia pathway_Homo sapiens_hsa034601.03524672
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.02314929
61Oxytocin signaling pathway_Homo sapiens_hsa049211.01566520
62Notch signaling pathway_Homo sapiens_hsa043301.01200255
63Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99174378
64GnRH signaling pathway_Homo sapiens_hsa049120.98637794
65Thyroid cancer_Homo sapiens_hsa052160.98578650
66Bladder cancer_Homo sapiens_hsa052190.98241801
67Parkinsons disease_Homo sapiens_hsa050120.98006741
68Axon guidance_Homo sapiens_hsa043600.97995941
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97467880
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.94918578
71Hedgehog signaling pathway_Homo sapiens_hsa043400.94501438
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94324182
73Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.94191628
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92271925
75Purine metabolism_Homo sapiens_hsa002300.92025952
76Gastric acid secretion_Homo sapiens_hsa049710.90866370
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.90711646
78MicroRNAs in cancer_Homo sapiens_hsa052060.89661510
79Wnt signaling pathway_Homo sapiens_hsa043100.89252275
80Huntingtons disease_Homo sapiens_hsa050160.88216143
81Vibrio cholerae infection_Homo sapiens_hsa051100.87318467
82Salivary secretion_Homo sapiens_hsa049700.85160304
83Alzheimers disease_Homo sapiens_hsa050100.84393371
84Long-term depression_Homo sapiens_hsa047300.83352470
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81147444
86Pentose phosphate pathway_Homo sapiens_hsa000300.80981145
87Nucleotide excision repair_Homo sapiens_hsa034200.80711951
88Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79454928
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76647416
90Melanoma_Homo sapiens_hsa052180.76497973
91Choline metabolism in cancer_Homo sapiens_hsa052310.74802198
92Phospholipase D signaling pathway_Homo sapiens_hsa040720.73306749
93Renal cell carcinoma_Homo sapiens_hsa052110.73210594
94Prolactin signaling pathway_Homo sapiens_hsa049170.73078207
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.72944179
96Phenylalanine metabolism_Homo sapiens_hsa003600.72805291
97Ribosome_Homo sapiens_hsa030100.71840202
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71659077
99Fructose and mannose metabolism_Homo sapiens_hsa000510.69588238
100Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69205704
101Endocytosis_Homo sapiens_hsa041440.68926466
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68401421
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.68218984
104One carbon pool by folate_Homo sapiens_hsa006700.68177160
105Homologous recombination_Homo sapiens_hsa034400.68166296
106Proteoglycans in cancer_Homo sapiens_hsa052050.67469006
107Insulin signaling pathway_Homo sapiens_hsa049100.67193781
108HTLV-I infection_Homo sapiens_hsa051660.66912920
109Rap1 signaling pathway_Homo sapiens_hsa040150.66216408
110Serotonergic synapse_Homo sapiens_hsa047260.66168733
111Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65123595
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64232113
113Renin secretion_Homo sapiens_hsa049240.64085642
1142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.63614323
115Pyruvate metabolism_Homo sapiens_hsa006200.62594753
116Dorso-ventral axis formation_Homo sapiens_hsa043200.62496497
117Glutathione metabolism_Homo sapiens_hsa004800.61982584
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.61647155
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61356940
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.61089547
121Type II diabetes mellitus_Homo sapiens_hsa049300.60873325
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.60763717
123Viral carcinogenesis_Homo sapiens_hsa052030.60561429
124Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60036109
125Calcium signaling pathway_Homo sapiens_hsa040200.59900844
126MAPK signaling pathway_Homo sapiens_hsa040100.59342613
127Tyrosine metabolism_Homo sapiens_hsa003500.58373450
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57778726
129Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57417892
130Peroxisome_Homo sapiens_hsa041460.56491395
131Fatty acid biosynthesis_Homo sapiens_hsa000610.55236193
132cAMP signaling pathway_Homo sapiens_hsa040240.55155176
133Acute myeloid leukemia_Homo sapiens_hsa052210.54119090
134Metabolic pathways_Homo sapiens_hsa011000.53070742
135Prion diseases_Homo sapiens_hsa050200.52921248
136AMPK signaling pathway_Homo sapiens_hsa041520.52101047
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48876369
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.47777502
139Arginine and proline metabolism_Homo sapiens_hsa003300.47492330
140Fatty acid elongation_Homo sapiens_hsa000620.46146158
141Carbon metabolism_Homo sapiens_hsa012000.45067243
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.41356943
143Pancreatic cancer_Homo sapiens_hsa052120.34138420
144Fatty acid metabolism_Homo sapiens_hsa012120.32710967
145Collecting duct acid secretion_Homo sapiens_hsa049660.25502599

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