TMEM123

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)6.55636751
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.13191422
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)6.13191422
4growth hormone receptor signaling pathway (GO:0060396)5.67057102
5regulation of RIG-I signaling pathway (GO:0039535)5.46549816
6myeloid dendritic cell differentiation (GO:0043011)5.28730143
7natural killer cell mediated immunity (GO:0002228)5.16591282
8natural killer cell mediated cytotoxicity (GO:0042267)5.16591282
9regulation of interleukin-12 biosynthetic process (GO:0045075)5.01450503
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.97864964
11cellular response to growth hormone stimulus (GO:0071378)4.92614078
12regulation of dendritic cell antigen processing and presentation (GO:0002604)4.90134380
13myeloid dendritic cell activation (GO:0001773)4.82168520
14regulation of necroptotic process (GO:0060544)4.79876401
15negative regulation of necroptotic process (GO:0060546)4.68770104
16CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.63048244
17T-helper cell differentiation (GO:0042093)4.63048244
18necroptotic process (GO:0070266)4.62300498
19regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)4.61638704
20positive regulation of natural killer cell differentiation (GO:0032825)4.59271158
21negative thymic T cell selection (GO:0045060)4.49622476
22response to muramyl dipeptide (GO:0032495)4.44882511
23neutrophil activation involved in immune response (GO:0002283)4.44682468
24dendritic cell differentiation (GO:0097028)4.41437177
25interferon-gamma secretion (GO:0072643)4.40807265
26neutrophil activation (GO:0042119)4.37923794
27positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.23587549
28negative regulation of fibrinolysis (GO:0051918)4.22775939
29positive regulation of antigen processing and presentation (GO:0002579)4.17646261
30negative T cell selection (GO:0043383)4.17218994
31regulation of T cell tolerance induction (GO:0002664)4.11387980
32granulocyte activation (GO:0036230)4.07192480
33very-low-density lipoprotein particle assembly (GO:0034379)4.06971769
34positive regulation of gamma-delta T cell activation (GO:0046645)4.00414474
35T cell differentiation involved in immune response (GO:0002292)3.99197232
36alpha-beta T cell differentiation involved in immune response (GO:0002293)3.99197232
37alpha-beta T cell activation involved in immune response (GO:0002287)3.99197232
38regulation of hypersensitivity (GO:0002883)3.96612461
39regulation of T-helper 1 cell differentiation (GO:0045625)3.85737696
40positive regulation of T cell cytokine production (GO:0002726)3.79038626
41mature B cell differentiation (GO:0002335)3.71384621
42regulation of antigen processing and presentation (GO:0002577)3.71266575
43positive regulation of interleukin-2 production (GO:0032743)3.69430584
44embryonic process involved in female pregnancy (GO:0060136)3.67491793
45positive regulation of interleukin-12 production (GO:0032735)3.67445418
46plasma lipoprotein particle assembly (GO:0034377)3.65477997
47negative regulation of necrotic cell death (GO:0060547)3.57387193
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.57351622
49pinocytosis (GO:0006907)3.56475740
50positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.49097568
51positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44756066
52programmed necrotic cell death (GO:0097300)3.43615943
53positive regulation of B cell differentiation (GO:0045579)3.40285850
54positive regulation of protein oligomerization (GO:0032461)3.39456223
55regulation of apoptotic cell clearance (GO:2000425)3.39057924
56cellular response to zinc ion (GO:0071294)3.37776012
57regulation of protein activation cascade (GO:2000257)3.37541223
58interferon-gamma-mediated signaling pathway (GO:0060333)3.35408399
59T cell migration (GO:0072678)3.34844159
60regulation of complement activation (GO:0030449)3.31968464
61lymphocyte migration (GO:0072676)3.31619106
62necrotic cell death (GO:0070265)3.31434158
63regulation of fibrinolysis (GO:0051917)3.31272055
64protein-lipid complex assembly (GO:0065005)3.31110741
65regulation of alpha-beta T cell proliferation (GO:0046640)3.27564084
66response to prostaglandin E (GO:0034695)3.25702147
67leukocyte mediated cytotoxicity (GO:0001909)3.24993772
68regulation of tolerance induction (GO:0002643)3.24810737
69positive regulation of humoral immune response (GO:0002922)3.23478966
70regulation of necrotic cell death (GO:0010939)3.22427582
71T cell activation involved in immune response (GO:0002286)3.22404543
72regulation of B cell differentiation (GO:0045577)3.16219723
73hypotonic response (GO:0006971)3.16015492
74regulation of natural killer cell differentiation (GO:0032823)3.13562257
75hepatocyte apoptotic process (GO:0097284)3.13334183
76thymic T cell selection (GO:0045061)3.12094070
77positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.10060504
78positive regulation of natural killer cell activation (GO:0032816)3.04317300
79regulation of interleukin-12 production (GO:0032655)3.03313184
80positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.02919068
81positive regulation of extracellular matrix organization (GO:1903055)3.02329787
82antigen processing and presentation via MHC class Ib (GO:0002475)3.01901246
83regulation of MHC class I biosynthetic process (GO:0045343)3.00484897
84T-helper 1 type immune response (GO:0042088)3.00301630
85peptidyl-glutamic acid carboxylation (GO:0017187)3.00092051
86protein carboxylation (GO:0018214)3.00092051
87regulation of response to interferon-gamma (GO:0060330)2.98839923
88regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.97724363
89positive regulation of hemostasis (GO:1900048)2.97249333
90positive regulation of blood coagulation (GO:0030194)2.97249333
91negative regulation of cell killing (GO:0031342)2.97188839
92negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.97188839
93CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.95920182
94CD4-positive, alpha-beta T cell activation (GO:0035710)2.90878661
95regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.90424665
96negative regulation of B cell activation (GO:0050869)2.89451823
97positive regulation of T-helper cell differentiation (GO:0045624)2.89138273
98regulation of type I interferon-mediated signaling pathway (GO:0060338)2.88851247
99dendritic cell migration (GO:0036336)2.88774405
100regulation of gamma-delta T cell differentiation (GO:0045586)2.88413320
101lymphocyte mediated immunity (GO:0002449)2.88017390
102cytokine secretion (GO:0050663)2.86786589
103T cell selection (GO:0045058)2.86534226
104response to interleukin-15 (GO:0070672)2.86063774
105positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.85634270
106natural killer cell differentiation (GO:0001779)2.83595840
107positive regulation of coagulation (GO:0050820)2.81874371
108negative regulation of alpha-beta T cell activation (GO:0046636)2.80390530
109regulation of T-helper 2 cell differentiation (GO:0045628)2.80335196
110negative regulation of innate immune response (GO:0045824)2.78768146
111regulation of immunoglobulin secretion (GO:0051023)2.77194327
112germinal center formation (GO:0002467)2.76485113
113regulation of cellular extravasation (GO:0002691)2.76285220
114cellular response to interleukin-15 (GO:0071350)2.75947735
115positive regulation of protein homooligomerization (GO:0032464)2.75775783
116positive regulation of pseudopodium assembly (GO:0031274)2.75716245
117positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.75586920
118definitive hemopoiesis (GO:0060216)2.67472757
119low-density lipoprotein particle remodeling (GO:0034374)2.66175800
120response to peptidoglycan (GO:0032494)2.63931370
121complement activation, alternative pathway (GO:0006957)2.62875241
122Golgi transport vesicle coating (GO:0048200)2.60949258
123COPI coating of Golgi vesicle (GO:0048205)2.60949258
124positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.59676918
125negative regulation of myeloid cell apoptotic process (GO:0033033)2.58203610
126positive regulation of granulocyte differentiation (GO:0030854)2.56854506
127regulation of superoxide anion generation (GO:0032928)2.56758090
128negative regulation of protein activation cascade (GO:2000258)2.55634198
129cellular response to type I interferon (GO:0071357)2.55193279
130type I interferon signaling pathway (GO:0060337)2.55193279
131cholesterol efflux (GO:0033344)2.53961569
132regulation of humoral immune response (GO:0002920)2.51094623
133response to type I interferon (GO:0034340)2.50007692
134fibrinolysis (GO:0042730)2.47676252
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46489894
136acute-phase response (GO:0006953)2.42398193
137response to laminar fluid shear stress (GO:0034616)2.42295583
138cellular response to ethanol (GO:0071361)2.40874554
139nuclear pore complex assembly (GO:0051292)2.37320077
140COPII vesicle coating (GO:0048208)2.35699593
141regulation of gamma-delta T cell activation (GO:0046643)2.35125988
142plasma lipoprotein particle organization (GO:0071827)2.34897068
143detection of molecule of bacterial origin (GO:0032490)2.33978525
144negative regulation of erythrocyte differentiation (GO:0045647)2.33659349
145blood coagulation, intrinsic pathway (GO:0007597)2.32958499
146positive regulation of interferon-alpha production (GO:0032727)2.27444894
147regulation of histone H3-K27 methylation (GO:0061085)2.25945647
148protein-lipid complex subunit organization (GO:0071825)2.24065288
149negative regulation of complement activation (GO:0045916)2.23083885
150regulation of interferon-alpha production (GO:0032647)2.22090450
151cell adhesion mediated by integrin (GO:0033627)2.21316533
152skin morphogenesis (GO:0043589)2.21071514
153regulation of cholesterol esterification (GO:0010872)2.20059486
154nuclear pore organization (GO:0006999)2.19783647
155low-density lipoprotein particle clearance (GO:0034383)2.19627453
156negative regulation of humoral immune response (GO:0002921)2.19386216
157response to thyroid hormone (GO:0097066)2.18961253
158regulation of extracellular matrix organization (GO:1903053)2.17292245
159detection of other organism (GO:0098543)2.16396875
160regulation of cholesterol homeostasis (GO:2000188)2.16027842
161negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.14944127
162negative regulation of interleukin-17 production (GO:0032700)2.14639607
163regulation of activation of Janus kinase activity (GO:0010533)2.14106327
164oligosaccharide catabolic process (GO:0009313)2.14027380
165negative regulation of interleukin-12 production (GO:0032695)2.13925939
166positive regulation of tolerance induction (GO:0002645)2.13793345
167cellular response to virus (GO:0098586)2.12292966
168positive regulation of phagocytosis (GO:0050766)2.11875912
169cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.11413268
170progesterone metabolic process (GO:0042448)2.10454205
171NIK/NF-kappaB signaling (GO:0038061)10.5537382

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.32635146
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.94251490
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.22568917
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.08463034
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.80965414
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.80956854
7STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.69811302
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.59660982
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.53617911
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.35496216
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.19277383
12IRF8_27001747_Chip-Seq_BMDM_Mouse3.09584688
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.08819961
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74050822
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73586590
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61840042
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.59783507
18RUNX_20019798_ChIP-Seq_JUKART_Human2.58866881
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.52249175
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50586468
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.50427297
22GATA1_22025678_ChIP-Seq_K562_Human2.47081127
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43830787
24MAF_26560356_Chip-Seq_TH1_Human2.34020714
25MYB_26560356_Chip-Seq_TH2_Human2.32364610
26VDR_21846776_ChIP-Seq_THP-1_Human2.10714751
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.10552507
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.04788355
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98430969
30* MYB_26560356_Chip-Seq_TH1_Human1.92118709
31VDR_24763502_ChIP-Seq_THP-1_Human1.85392723
32* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84617287
33RXR_22158963_ChIP-Seq_LIVER_Mouse1.83219749
34* TCF7_22412390_ChIP-Seq_EML_Mouse1.82728149
35Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.75963656
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74761515
37PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.73468235
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71618142
39* SPI1_23547873_ChIP-Seq_NB4_Human1.69533200
40* VDR_24787735_ChIP-Seq_THP-1_Human1.68220872
41PPARA_22158963_ChIP-Seq_LIVER_Mouse1.63910645
42* MYC_22102868_ChIP-Seq_BL_Human1.62806854
43SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60013579
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.59616323
45LXR_22158963_ChIP-Seq_LIVER_Mouse1.58055813
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.55637408
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.53679986
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52581846
49SCL_19346495_ChIP-Seq_HPC-7_Human1.50887146
50* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.44604025
51CLOCK_20551151_ChIP-Seq_293T_Human1.44227308
52TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41369588
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.40350982
54UTX_26944678_Chip-Seq_JUKART_Human1.40339783
55AR_21909140_ChIP-Seq_LNCAP_Human1.39000232
56KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38059902
57* KDM2B_26808549_Chip-Seq_DND41_Human1.34267955
58PU_27001747_Chip-Seq_BMDM_Mouse1.33920214
59SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30422278
60MAF_26560356_Chip-Seq_TH2_Human1.30311017
61SPI1_23127762_ChIP-Seq_K562_Human1.29405248
62* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28631574
63* RUNX1_22412390_ChIP-Seq_EML_Mouse1.28367739
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27610893
65PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27062321
66* FOXA2_19822575_ChIP-Seq_HepG2_Human1.26854668
67* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.25771178
68* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25401417
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22157825
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20959756
71ZNF263_19887448_ChIP-Seq_K562_Human1.20478784
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20326926
73PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19170996
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17628336
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.17452461
76* GATA3_26560356_Chip-Seq_TH2_Human1.17147356
77* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16723762
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16537440
79SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16537440
80ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15149397
81* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15040719
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13630202
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10961938
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.09167650
85PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08845311
86MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06144230
87BP1_19119308_ChIP-ChIP_Hs578T_Human1.03330580
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.02705279
89GATA2_21666600_ChIP-Seq_HMVEC_Human1.02639976
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02337029
91* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02103747
92TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01108002
93SMRT_27268052_Chip-Seq_Bcells_Human0.99452471
94CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99255522
95RARG_19884340_ChIP-ChIP_MEFs_Mouse0.98107421
96FOXM1_23109430_ChIP-Seq_U2OS_Human0.96128642
97ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93457379
98* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93064763
99SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92435025
100* GATA6_25053715_ChIP-Seq_YYC3_Human0.91225764
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90989432
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.90908852
103GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90857130
104HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90446510
105* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.90337433
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89944597
107NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.88972534
108EGR1_19032775_ChIP-ChIP_M12_Human0.88737644
109GATA4_25053715_ChIP-Seq_YYC3_Human0.88190025
110ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86216115
111CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.86130182
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86116096
113NOTCH1_21737748_ChIP-Seq_TLL_Human0.85193829
114* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.84783338
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.84686227
116* UBF1/2_26484160_Chip-Seq_HMECs_Human0.83492103
117CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.82768130
118GATA1_19941826_ChIP-Seq_K562_Human0.82682203
119TFEB_21752829_ChIP-Seq_HELA_Human0.81810224
120* KDM2B_26808549_Chip-Seq_JURKAT_Human0.81027179
121* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78538170
122E2F7_22180533_ChIP-Seq_HELA_Human0.78175506
123PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78151222
124JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76559236
125CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.74100675
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74090404
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72423504
128NCOR1_26117541_ChIP-Seq_K562_Human0.71946843
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.71716104
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.71528284
131MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.71405551
132JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.70829499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system5.57965308
2MP0002254_reproductive_system_inflammat4.90762041
3MP0001835_abnormal_antigen_presentation4.22039224
4MP0002166_altered_tumor_susceptibility3.98422276
5MP0002009_preneoplasia3.98325284
6MP0000685_abnormal_immune_system3.69536660
7MP0004510_myositis3.49580678
8MP0002006_tumorigenesis3.11978079
9MP0001348_abnormal_lacrimal_gland3.02901730
10MP0005387_immune_system_phenotype3.01980046
11MP0001790_abnormal_immune_system3.01980046
12MP0001800_abnormal_humoral_immune2.65007668
13MP0002877_abnormal_melanocyte_morpholog2.58738192
14MP0002148_abnormal_hypersensitivity_rea2.52885166
15MP0003436_decreased_susceptibility_to2.48733811
16MP0002139_abnormal_hepatobiliary_system2.48629181
17MP0005000_abnormal_immune_tolerance2.41093457
18MP0002452_abnormal_antigen_presenting2.39090680
19MP0005671_abnormal_response_to2.32296980
20MP0002163_abnormal_gland_morphology2.25714106
21MP0001873_stomach_inflammation2.25630955
22MP0005310_abnormal_salivary_gland2.23423592
23MP0002723_abnormal_immune_serum2.23079198
24MP0001819_abnormal_immune_cell2.11907009
25MP0002420_abnormal_adaptive_immunity2.11088338
26MP0009785_altered_susceptibility_to2.10621107
27MP0002419_abnormal_innate_immunity1.94348929
28MP0000569_abnormal_digit_pigmentation1.94293198
29MP0005025_abnormal_response_to1.86008867
30MP0006054_spinal_hemorrhage1.79869569
31MP0010352_gastrointestinal_tract_polyps1.79067708
32MP0001346_abnormal_lacrimal_gland1.78925997
33MP0005451_abnormal_body_composition1.77802930
34MP0004947_skin_inflammation1.75508964
35MP0000716_abnormal_immune_system1.74897922
36MP0002398_abnormal_bone_marrow1.74420010
37MP0002277_abnormal_respiratory_mucosa1.70938590
38MP0003300_gastrointestinal_ulcer1.60418891
39MP0001853_heart_inflammation1.57680431
40MP0002396_abnormal_hematopoietic_system1.56209857
41MP0003806_abnormal_nucleotide_metabolis1.55841335
42MP0003303_peritoneal_inflammation1.55094478
43MP0003763_abnormal_thymus_physiology1.54149279
44MP0001915_intracranial_hemorrhage1.51343538
45MP0009697_abnormal_copulation1.51157579
46MP0003656_abnormal_erythrocyte_physiolo1.45717069
47MP0002405_respiratory_system_inflammati1.44927247
48MP0005365_abnormal_bile_salt1.42514359
49MP0010155_abnormal_intestine_physiology1.40678594
50MP0002429_abnormal_blood_cell1.39177960
51MP0003453_abnormal_keratinocyte_physiol1.36541853
52MP0005409_darkened_coat_color1.35564276
53MP0003091_abnormal_cell_migration1.33232902
54MP0000465_gastrointestinal_hemorrhage1.31445781
55MP0005408_hypopigmentation1.30481987
56MP0001851_eye_inflammation1.29901769
57MP0008260_abnormal_autophagy1.29184084
58MP0000689_abnormal_spleen_morphology1.28261480
59MP0002132_abnormal_respiratory_system1.25336254
60MP0003252_abnormal_bile_duct1.24812930
61MP0002722_abnormal_immune_system1.24643327
62MP0005360_urolithiasis1.23085806
63MP0001845_abnormal_inflammatory_respons1.21763312
64MP0005076_abnormal_cell_differentiation1.21710242
65MP0004264_abnormal_extraembryonic_tissu1.18888255
66MP0010368_abnormal_lymphatic_system1.17828775
67MP0003448_altered_tumor_morphology1.16952660
68MP0001879_abnormal_lymphatic_vessel1.16809673
69MP0005164_abnormal_response_to1.16640303
70MP0001666_abnormal_nutrient_absorption1.13466522
71MP0002933_joint_inflammation1.08941904
72MP0005085_abnormal_gallbladder_physiolo1.08444888
73MP0001533_abnormal_skeleton_physiology1.07384857
74MP0005379_endocrine/exocrine_gland_phen1.06515003
75MP0008875_abnormal_xenobiotic_pharmacok1.05988996
76MP0008057_abnormal_DNA_replication1.05251131
77MP0003705_abnormal_hypodermis_morpholog1.02903338
78MP0000703_abnormal_thymus_morphology1.02547146
79MP0008469_abnormal_protein_level1.00380111
80MP0003221_abnormal_cardiomyocyte_apopto1.00136204
81MP0005397_hematopoietic_system_phenotyp0.99838591
82MP0001545_abnormal_hematopoietic_system0.99838591
83MP0004883_abnormal_blood_vessel0.99051033
84MP0005058_abnormal_lysosome_morphology0.97090977
85MP0004808_abnormal_hematopoietic_stem0.96687106
86MP0005464_abnormal_platelet_physiology0.96453133
87MP0001243_abnormal_dermal_layer0.95551623
88MP0003868_abnormal_feces_composition0.94884692
89MP0010234_abnormal_vibrissa_follicle0.94771852
90MP0005023_abnormal_wound_healing0.94499834
91MP0003566_abnormal_cell_adhesion0.90644542
92MP0003724_increased_susceptibility_to0.90380296
93MP0000604_amyloidosis0.89252153
94MP0009333_abnormal_splenocyte_physiolog0.88042108
95MP0010329_abnormal_lipoprotein_level0.87675266
96MP0009763_increased_sensitivity_to0.87650405
97MP0009764_decreased_sensitivity_to0.87019360
98MP0000598_abnormal_liver_morphology0.86881442
99MP0002998_abnormal_bone_remodeling0.85923796
100MP0006082_CNS_inflammation0.85578015
101MP0005621_abnormal_cell_physiology0.84861111
102MP0005174_abnormal_tail_pigmentation0.82690756
103MP0003075_altered_response_to0.82235797
104MP0000858_altered_metastatic_potential0.80557660
105MP0000767_abnormal_smooth_muscle0.78577543
106MP0001881_abnormal_mammary_gland0.74615555
107MP0003943_abnormal_hepatobiliary_system0.74206886
108MP0000249_abnormal_blood_vessel0.72971426
109MP0009840_abnormal_foam_cell0.71584924
110MP0003195_calcinosis0.70724631
111MP0001730_embryonic_growth_arrest0.70380774
112MP0000627_abnormal_mammary_gland0.68765038
113MP0002136_abnormal_kidney_physiology0.68643354
114MP0000371_diluted_coat_color0.65917238
115MP0000733_abnormal_muscle_development0.64257591
116MP0003191_abnormal_cellular_cholesterol0.63249425
117MP0001216_abnormal_epidermal_layer0.62449368
118MP0002019_abnormal_tumor_incidence0.58674890
119MP0003866_abnormal_defecation0.57787241
120MP0001958_emphysema0.57108692
121MP0009278_abnormal_bone_marrow0.53775024
122MP0002295_abnormal_pulmonary_circulatio0.52738059
123MP0003183_abnormal_peptide_metabolism0.52531415
124MP0008007_abnormal_cellular_replicative0.52432632
125MP0001191_abnormal_skin_condition0.51942339
126MP0010307_abnormal_tumor_latency0.51470552
127MP0003828_pulmonary_edema0.51422013
128MP0001765_abnormal_ion_homeostasis0.50364304
129MP0004185_abnormal_adipocyte_glucose0.49167153
130MP0003045_fibrosis0.47330541
131MP0000609_abnormal_liver_physiology0.47256688
132MP0000490_abnormal_crypts_of0.46282078
133MP0000613_abnormal_salivary_gland0.45535048
134MP0003172_abnormal_lysosome_physiology0.45136946

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)5.59030442
2Fatigue (HP:0012378)5.38730624
3Recurrent viral infections (HP:0004429)5.27432365
4Recurrent fungal infections (HP:0002841)4.83383361
5Chronic otitis media (HP:0000389)4.75903349
6Recurrent bacterial skin infections (HP:0005406)4.31871581
7Thrombocytosis (HP:0001894)4.19129307
8Eczematoid dermatitis (HP:0000976)4.18830044
9Increased IgE level (HP:0003212)4.14100290
10Agammaglobulinemia (HP:0004432)4.12124927
11Recurrent abscess formation (HP:0002722)4.00759856
12Abnormal delayed hypersensitivity skin test (HP:0002963)3.99008905
13Gastrointestinal infarctions (HP:0005244)3.86263304
14Polycythemia (HP:0001901)3.85894443
15Colitis (HP:0002583)3.85025878
16Myocardial infarction (HP:0001658)3.83351988
17Nasal polyposis (HP:0100582)3.80424653
18Abnormality of the common coagulation pathway (HP:0010990)3.78831751
19Hematochezia (HP:0002573)3.72612203
20Retrobulbar optic neuritis (HP:0100654)3.71428931
21Optic neuritis (HP:0100653)3.71428931
22Mediastinal lymphadenopathy (HP:0100721)3.68580544
23Peritonitis (HP:0002586)3.65500396
24Myositis (HP:0100614)3.63349721
25Pulmonary infiltrates (HP:0002113)3.56732228
26Osteolytic defects of the phalanges of the hand (HP:0009771)3.50591207
27Osteolytic defects of the hand bones (HP:0009699)3.50591207
28Orchitis (HP:0100796)3.50085378
29Arterial thrombosis (HP:0004420)3.46559224
30Recurrent bronchitis (HP:0002837)3.45808041
31Vasculitis (HP:0002633)3.41940727
32Elevated erythrocyte sedimentation rate (HP:0003565)3.39850499
33Abnormality of the nasal mucosa (HP:0000433)3.39514986
34Flat acetabular roof (HP:0003180)3.31136492
35Eosinophilia (HP:0001880)3.29661371
36Cortical dysplasia (HP:0002539)3.28676663
37Recurrent skin infections (HP:0001581)3.28659723
38Inflammation of the large intestine (HP:0002037)3.28215085
39Abnormality of the fingertips (HP:0001211)3.19277412
40Prolonged partial thromboplastin time (HP:0003645)3.15853285
41Chronic mucocutaneous candidiasis (HP:0002728)3.10450496
42Recurrent cutaneous fungal infections (HP:0011370)3.10450496
43Gastrointestinal inflammation (HP:0004386)3.09886350
44Joint hemorrhage (HP:0005261)3.06048219
45Periodontitis (HP:0000704)3.05670791
46Panhypogammaglobulinemia (HP:0003139)3.05304588
47Complement deficiency (HP:0004431)3.04229311
48Hypergammaglobulinemia (HP:0010702)3.01069693
49Cellulitis (HP:0100658)2.98040005
50Autoimmune thrombocytopenia (HP:0001973)2.97877074
51Leukocytosis (HP:0001974)2.96519106
52Granulocytopenia (HP:0001913)2.96017438
53Abnormality of macrophages (HP:0004311)2.93705965
54Hemorrhage of the eye (HP:0011885)2.91066462
55Esophageal varix (HP:0002040)2.89576924
56Cerebral hemorrhage (HP:0001342)2.88741197
57Increased IgM level (HP:0003496)2.81702728
58Gingival bleeding (HP:0000225)2.80555597
59Abnormality of T cell number (HP:0011839)2.79041991
60Verrucae (HP:0200043)2.75508557
61Papilloma (HP:0012740)2.75508557
62Hypobetalipoproteinemia (HP:0003563)2.72832323
63Gastrointestinal stroma tumor (HP:0100723)2.72042145
64Abnormality of complement system (HP:0005339)2.71525171
65Anhidrosis (HP:0000970)2.71474939
66Emphysema (HP:0002097)2.68214563
67Interstitial pulmonary disease (HP:0006530)2.67901695
68Meningitis (HP:0001287)2.67115029
69Systemic lupus erythematosus (HP:0002725)2.65865462
70Chest pain (HP:0100749)2.60711679
71Spontaneous hematomas (HP:0007420)2.57852734
72Abnormality of eosinophils (HP:0001879)2.57127622
73Persistence of primary teeth (HP:0006335)2.51544556
74Chronic sinusitis (HP:0011109)2.51288292
75Purpura (HP:0000979)2.51268947
76Abnormality of T cell physiology (HP:0011840)2.50497730
77Abnormality of the lumbar spine (HP:0100712)2.49239124
78Abnormality of cells of the lymphoid lineage (HP:0012140)2.46252595
79Acute myeloid leukemia (HP:0004808)2.43469699
80Abnormal foot bone ossification (HP:0010675)2.41244854
81Abnormality of T cells (HP:0002843)2.39272265
82Glomerulonephritis (HP:0000099)2.39057886
83Dysostosis multiplex (HP:0000943)2.34470799
84Lymphopenia (HP:0001888)2.33244672
85Pustule (HP:0200039)2.31455871
86Menorrhagia (HP:0000132)2.31222961
87Keratoconjunctivitis sicca (HP:0001097)2.29152629
88Abnormality of monocarboxylic acid metabolism (HP:0010996)2.27522264
89T lymphocytopenia (HP:0005403)2.27468306
90Amaurosis fugax (HP:0100576)2.25639065
91Gingivitis (HP:0000230)2.25186315
92Hemoptysis (HP:0002105)2.23221850
93Thyroiditis (HP:0100646)2.22472338
94Recurrent gram-negative bacterial infections (HP:0005420)2.21837468
95Encephalitis (HP:0002383)2.20719088
96Chronic diarrhea (HP:0002028)2.19515086
97Epistaxis (HP:0000421)2.18917994
98Osteomyelitis (HP:0002754)2.18324975
99Abnormality of carpal bone ossification (HP:0006257)2.16830710
100Broad palm (HP:0001169)2.16713228
101Keratoconjunctivitis (HP:0001096)2.15629199
102Urinary glycosaminoglycan excretion (HP:0003541)2.15283985
103Mucopolysacchariduria (HP:0008155)2.15283985
104Pulmonary embolism (HP:0002204)2.14968045
105Autoimmune hemolytic anemia (HP:0001890)2.14846892
106Ankyloglossia (HP:0010296)2.13688127
107Subacute progressive viral hepatitis (HP:0006572)2.13683956
108Tetraparesis (HP:0002273)2.11568233
109Vertebral compression fractures (HP:0002953)2.11107345
110Mitral stenosis (HP:0001718)2.10930403
111Prolonged bleeding time (HP:0003010)2.10755397
112Abnormality of the peritoneum (HP:0002585)2.07783751
113Porencephaly (HP:0002132)2.05920041
114IgA deficiency (HP:0002720)2.05713360
115Small epiphyses (HP:0010585)2.04533302
116Skin ulcer (HP:0200042)2.04454478
117Abnormality of glycolipid metabolism (HP:0010969)2.04250359
118Abnormality of liposaccharide metabolism (HP:0010968)2.04250359
119Abnormality of glycosphingolipid metabolism (HP:0004343)2.04250359
120Abnormal tarsal ossification (HP:0008369)2.03785346
121Coarse hair (HP:0002208)2.03234552
122Portal hypertension (HP:0001409)2.01048328
123Hypercholesterolemia (HP:0003124)2.00747525
124Cupped ribs (HP:0000887)2.00396337
125Asymmetry of the thorax (HP:0001555)2.00143591
126Abnormality of the periventricular white matter (HP:0002518)1.99548985
127Thickened calvaria (HP:0002684)1.98731295
128Conjugated hyperbilirubinemia (HP:0002908)1.98662044
129Pulmonary artery stenosis (HP:0004415)1.97709373
130Gangrene (HP:0100758)1.96655895
131Recurrent lower respiratory tract infections (HP:0002783)1.95609286
132Viral hepatitis (HP:0006562)1.94685833
133Abnormality of the intrinsic pathway (HP:0010989)1.93760496
134Abnormality of oral frenula (HP:0000190)1.92778308
135Stomach cancer (HP:0012126)1.91616251
136Amyloidosis (HP:0011034)1.91373249
137Abnormality of B cell number (HP:0010975)1.91324832
138B lymphocytopenia (HP:0010976)1.91324832
139Abnormality of polysaccharide metabolism (HP:0011012)1.90171225
140Abnormality of glycosaminoglycan metabolism (HP:0004371)1.90171225
141Abnormality of mucopolysaccharide metabolism (HP:0011020)1.90171225
142Recurrent pneumonia (HP:0006532)1.89236212
143Joint swelling (HP:0001386)1.86318178
144Exertional dyspnea (HP:0002875)1.85857174
145Bronchitis (HP:0012387)1.85776240
146Vascular calcification (HP:0004934)1.85736567
147Thrombophlebitis (HP:0004418)1.85375186
148Abnormality of the acetabulum (HP:0003170)1.83410387
149Papillary thyroid carcinoma (HP:0002895)1.82369115
150Flared iliac wings (HP:0002869)1.81743121
151Scanning speech (HP:0002168)1.80047713
152Glomerulopathy (HP:0100820)1.78843074
153Vacuolated lymphocytes (HP:0001922)1.72830807
154Abnormal platelet volume (HP:0011876)1.72805930
15511 pairs of ribs (HP:0000878)1.71110357
156Xanthomatosis (HP:0000991)1.70885646
157Abnormal ossification of hand bones (HP:0005921)1.70442932
158Syringomyelia (HP:0003396)1.70170928
159Spinal cord lesions (HP:0100561)1.70170928
160Broad alveolar ridges (HP:0000187)1.69181475
161Arterial tortuosity (HP:0005116)1.67990940

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.85971054
2MAP3K134.18082860
3TYK23.90557787
4IKBKB3.76939761
5JAK33.48215847
6CHUK2.98239299
7JAK12.78528292
8TBK12.77085317
9EPHB12.58646187
10FLT32.51474434
11PRPF4B2.41625280
12IKBKE2.36177030
13LATS12.21159409
14MAP4K12.17297940
15KIT2.08068822
16MST1R2.06851709
17CSF1R1.98067188
18IRAK41.86298605
19PRKAA21.84686770
20FGFR41.82655663
21EPHA31.68610554
22PKN11.66425484
23NEK91.59234616
24PDGFRA1.55619880
25FGFR31.49294446
26EPHA21.46960132
27BRD41.45871298
28MAP3K21.44114722
29ICK1.43269890
30LRRK21.37016770
31PTK61.36589340
32MATK1.31125471
33MAP3K101.27696639
34MAP3K61.26124062
35BTK1.18382214
36YES11.18089662
37SYK1.16671178
38GRK61.16622265
39TTN1.14066599
40NLK1.13367214
41JAK21.11245543
42RPS6KA41.10178435
43SIK31.08035808
44SMG11.04202394
45CDK41.03721863
46ZAP701.02832094
47KSR21.00553207
48STK100.99503557
49PIM10.99336424
50CAMKK20.96909473
51RIPK40.95887871
52LCK0.95817181
53BLK0.94886958
54TAOK30.94778027
55IRAK10.92262408
56MET0.90569837
57MAPKAPK20.89141188
58MAP3K10.88896689
59MAPK110.83723730
60TRIB30.82854210
61TEC0.81969445
62CSK0.81295837
63TGFBR10.80268697
64RET0.80123206
65EIF2AK30.78157780
66STK40.77318014
67RPS6KB20.76202756
68ITK0.73587211
69TAOK20.73449835
70PRKCQ0.72542648
71EIF2AK10.69717976
72BMX0.69368594
73TRPM70.68647733
74CLK10.68551147
75CDK120.66555197
76SCYL20.66475619
77MST40.66470486
78RPS6KA50.65010953
79STK30.64276167
80HCK0.63338642
81RIPK10.62958099
82ERN10.61554481
83LATS20.60875058
84CDK70.59659333
85MAP2K30.58758644
86BRSK20.58566916
87PAK40.58073184
88HIPK20.56196253
89IRAK20.55706291
90FES0.55563666
91WNK10.54537971
92IRAK30.54379712
93PDGFRB0.53513731
94SRPK10.50831200
95PASK0.50499858
96ERBB30.50423660
97STK240.49663698
98ABL10.49580190
99PIM20.49473198
100DYRK1B0.48886978
101TXK0.47953323
102NUAK10.47922743
103SGK10.47036143
104PBK0.46608792
105RPS6KA10.46446854
106MAP3K50.44810953
107RAF10.44322025
108BMPR20.44264856
109ACVR1B0.44087597
110FGR0.44039570
111MAP2K20.43901723
112SGK30.43659983
113MELK0.43513049
114FGFR10.43219929
115PRKCD0.42861356
116LYN0.42826001
117EIF2AK20.42599732
118KDR0.42459303
119GSK3A0.42296857
120MAP3K30.41539172
121AKT10.41054562
122MAP3K70.41013167
123CDK90.40689931
124CDK60.39657326
125MAP3K80.39207646
126EEF2K0.38662703
127EGFR0.38210346
128TESK20.36302066
129TGFBR20.34985093
130BCR0.32710547
131MOS0.31828595
132PRKCZ0.31315502
133PAK30.29721751
134DYRK30.29113928
135DMPK0.28486804
136FGFR20.27084340
137SIK10.26057437
138INSR0.25824917
139PKN20.25014911

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040643.92108611
2Intestinal immune network for IgA production_Homo sapiens_hsa046722.90305768
3Leishmaniasis_Homo sapiens_hsa051402.76074452
4Complement and coagulation cascades_Homo sapiens_hsa046102.75025094
5Other glycan degradation_Homo sapiens_hsa005112.72921851
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69078270
7Allograft rejection_Homo sapiens_hsa053302.66920374
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.65547019
9Toxoplasmosis_Homo sapiens_hsa051452.43725034
10Antigen processing and presentation_Homo sapiens_hsa046122.41218508
11TNF signaling pathway_Homo sapiens_hsa046682.40487479
12Osteoclast differentiation_Homo sapiens_hsa043802.38673057
13Measles_Homo sapiens_hsa051622.37097543
14B cell receptor signaling pathway_Homo sapiens_hsa046622.31356939
15Primary immunodeficiency_Homo sapiens_hsa053402.26388194
16Graft-versus-host disease_Homo sapiens_hsa053322.21989359
17Apoptosis_Homo sapiens_hsa042102.19093390
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98371552
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.87652198
20Small cell lung cancer_Homo sapiens_hsa052221.86125681
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.84989170
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.82420395
23Autoimmune thyroid disease_Homo sapiens_hsa053201.78521744
24Chemokine signaling pathway_Homo sapiens_hsa040621.73916478
25Herpes simplex infection_Homo sapiens_hsa051681.73206840
26T cell receptor signaling pathway_Homo sapiens_hsa046601.62158297
27Shigellosis_Homo sapiens_hsa051311.55910757
28Viral myocarditis_Homo sapiens_hsa054161.52897596
29Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51082563
30Legionellosis_Homo sapiens_hsa051341.48022552
31Influenza A_Homo sapiens_hsa051641.47501568
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.46984444
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.43779256
34Acute myeloid leukemia_Homo sapiens_hsa052211.42257068
35Tuberculosis_Homo sapiens_hsa051521.33204767
36Hematopoietic cell lineage_Homo sapiens_hsa046401.32342227
37Chronic myeloid leukemia_Homo sapiens_hsa052201.30142584
38Epstein-Barr virus infection_Homo sapiens_hsa051691.28479113
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.27177724
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.23382773
41Transcriptional misregulation in cancer_Homo sapiens_hsa052021.21592617
42Pertussis_Homo sapiens_hsa051331.21399055
43p53 signaling pathway_Homo sapiens_hsa041151.19033579
44Leukocyte transendothelial migration_Homo sapiens_hsa046701.16461503
45Viral carcinogenesis_Homo sapiens_hsa052031.11217979
46Malaria_Homo sapiens_hsa051441.10346373
47Prolactin signaling pathway_Homo sapiens_hsa049171.10235841
48Hepatitis B_Homo sapiens_hsa051611.10026814
49Hepatitis C_Homo sapiens_hsa051601.09502254
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.08770970
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.08375369
52Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.08189187
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07117874
54Pancreatic cancer_Homo sapiens_hsa052121.02036669
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01667436
56Adipocytokine signaling pathway_Homo sapiens_hsa049201.00987933
57Type I diabetes mellitus_Homo sapiens_hsa049400.99676181
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.99085663
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98924359
60Thyroid cancer_Homo sapiens_hsa052160.96435798
61N-Glycan biosynthesis_Homo sapiens_hsa005100.92912110
62Salmonella infection_Homo sapiens_hsa051320.87869305
63HTLV-I infection_Homo sapiens_hsa051660.87308209
64MicroRNAs in cancer_Homo sapiens_hsa052060.86795056
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85123410
66Insulin resistance_Homo sapiens_hsa049310.84892773
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82550413
68Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.80883350
69Pentose phosphate pathway_Homo sapiens_hsa000300.80730581
70Starch and sucrose metabolism_Homo sapiens_hsa005000.79098269
71Bladder cancer_Homo sapiens_hsa052190.78366843
72Platelet activation_Homo sapiens_hsa046110.77378714
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75669381
74Neurotrophin signaling pathway_Homo sapiens_hsa047220.74917597
75Prion diseases_Homo sapiens_hsa050200.74465021
76Fatty acid biosynthesis_Homo sapiens_hsa000610.74459683
77African trypanosomiasis_Homo sapiens_hsa051430.74112963
78Endometrial cancer_Homo sapiens_hsa052130.67369988
79Asthma_Homo sapiens_hsa053100.65298193
80Staphylococcus aureus infection_Homo sapiens_hsa051500.65274663
81MAPK signaling pathway_Homo sapiens_hsa040100.64851695
82Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64160999
83Rheumatoid arthritis_Homo sapiens_hsa053230.60210330
84Non-homologous end-joining_Homo sapiens_hsa034500.59938898
85Pathways in cancer_Homo sapiens_hsa052000.59614447
86Primary bile acid biosynthesis_Homo sapiens_hsa001200.59311592
87Inositol phosphate metabolism_Homo sapiens_hsa005620.56967090
88Proteoglycans in cancer_Homo sapiens_hsa052050.56240930
89VEGF signaling pathway_Homo sapiens_hsa043700.55640170
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.55545546
91FoxO signaling pathway_Homo sapiens_hsa040680.54090353
92PPAR signaling pathway_Homo sapiens_hsa033200.53718448
93Fatty acid degradation_Homo sapiens_hsa000710.52728907
94Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51943044
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51191917
96Choline metabolism in cancer_Homo sapiens_hsa052310.50454975
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50093127
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.49476799
99Non-small cell lung cancer_Homo sapiens_hsa052230.49030186
100Focal adhesion_Homo sapiens_hsa045100.48619468
101Amoebiasis_Homo sapiens_hsa051460.48429866
102Prostate cancer_Homo sapiens_hsa052150.48046893
103HIF-1 signaling pathway_Homo sapiens_hsa040660.48006122
104Tyrosine metabolism_Homo sapiens_hsa003500.47811022
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47654757
106Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47336401
107Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46913107
108Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46885484
109Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41311770
110Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.40686079
111Endocytosis_Homo sapiens_hsa041440.40014069
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38811137
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35862702
114Renal cell carcinoma_Homo sapiens_hsa052110.34282105
115Dorso-ventral axis formation_Homo sapiens_hsa043200.33851674
116Systemic lupus erythematosus_Homo sapiens_hsa053220.31450324
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30822368
118Adherens junction_Homo sapiens_hsa045200.30628307
119Type II diabetes mellitus_Homo sapiens_hsa049300.29217971
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.28976547
121Thyroid hormone signaling pathway_Homo sapiens_hsa049190.28776184
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.28177078
123Ovarian steroidogenesis_Homo sapiens_hsa049130.27554129
124Lysosome_Homo sapiens_hsa041420.26326199
125Dilated cardiomyopathy_Homo sapiens_hsa054140.25642776
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25630794
127Notch signaling pathway_Homo sapiens_hsa043300.23452937
128Colorectal cancer_Homo sapiens_hsa052100.23415676
129Phenylalanine metabolism_Homo sapiens_hsa003600.20420043
130mTOR signaling pathway_Homo sapiens_hsa041500.20194575
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.18619723

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