TMEM125

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)8.84162366
2surfactant homeostasis (GO:0043129)8.61496566
3axonemal dynein complex assembly (GO:0070286)7.73971651
4chemical homeostasis within a tissue (GO:0048875)7.14348527
5ensheathment of neurons (GO:0007272)6.99670860
6axon ensheathment (GO:0008366)6.99670860
7myelination (GO:0042552)6.94951793
8long-chain fatty acid biosynthetic process (GO:0042759)6.10445684
9cilium or flagellum-dependent cell motility (GO:0001539)5.66002759
10primary alcohol catabolic process (GO:0034310)5.61847599
11cilium movement (GO:0003341)5.35687677
12cholesterol biosynthetic process (GO:0006695)5.34597739
13myelin maintenance (GO:0043217)5.29365511
14creatine metabolic process (GO:0006600)5.07527049
15motile cilium assembly (GO:0044458)4.98678718
16multicellular organismal water homeostasis (GO:0050891)4.94380412
17ethanol metabolic process (GO:0006067)4.86864145
18vitamin transmembrane transport (GO:0035461)4.84362718
19sterol biosynthetic process (GO:0016126)4.72255163
20oligodendrocyte differentiation (GO:0048709)4.69598063
21negative regulation of neurotransmitter secretion (GO:0046929)4.69584488
22long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.63984323
23regulation of collateral sprouting (GO:0048670)4.63285594
24desmosome organization (GO:0002934)4.52906495
25one-carbon compound transport (GO:0019755)4.51210108
26amyloid precursor protein metabolic process (GO:0042982)4.38787774
27negative regulation of neurotransmitter transport (GO:0051589)4.23854338
28long-chain fatty-acyl-CoA metabolic process (GO:0035336)4.23309533
29ethanol oxidation (GO:0006069)4.22172708
30glycerophospholipid catabolic process (GO:0046475)4.21212922
31epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.20444469
32epithelial cilium movement (GO:0003351)4.19377918
33water homeostasis (GO:0030104)4.19297034
34fatty-acyl-CoA biosynthetic process (GO:0046949)4.16070289
35response to methylmercury (GO:0051597)4.12353123
36substantia nigra development (GO:0021762)4.09115413
37establishment of mitochondrion localization (GO:0051654)4.09112196
38cellular response to nitric oxide (GO:0071732)4.06286384
39intestinal epithelial cell development (GO:0060576)4.04980791
40isoprenoid biosynthetic process (GO:0008299)4.04767427
41response to redox state (GO:0051775)4.04388043
42negative regulation of protein localization to cell surface (GO:2000009)4.00245202
43peptidyl-tyrosine autophosphorylation (GO:0038083)3.97272295
44sodium ion homeostasis (GO:0055078)3.95761700
45adhesion of symbiont to host cell (GO:0044650)3.95476933
46virion attachment to host cell (GO:0019062)3.95476933
47photoreceptor cell differentiation (GO:0046530)3.94143122
48eye photoreceptor cell differentiation (GO:0001754)3.94143122
49axoneme assembly (GO:0035082)3.91608125
50fatty-acyl-CoA metabolic process (GO:0035337)3.89825671
51establishment of apical/basal cell polarity (GO:0035089)3.86975791
52apical protein localization (GO:0045176)3.86583719
53very long-chain fatty acid metabolic process (GO:0000038)3.83086220
54tight junction assembly (GO:0070830)3.82252466
55astrocyte development (GO:0014002)3.76458991
56asymmetric protein localization (GO:0008105)3.74661885
57positive regulation of oligodendrocyte differentiation (GO:0048714)3.72783513
58L-phenylalanine catabolic process (GO:0006559)3.72597967
59erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.72597967
60L-amino acid import (GO:0043092)3.61574464
61heme transport (GO:0015886)3.61045893
62response to lipoprotein particle (GO:0055094)3.53256382
63myelination in peripheral nervous system (GO:0022011)3.52946781
64peripheral nervous system axon ensheathment (GO:0032292)3.52946781
65bundle of His cell to Purkinje myocyte communication (GO:0086069)3.52805635
66diterpenoid biosynthetic process (GO:0016102)3.52469467
67regulation of water loss via skin (GO:0033561)3.51417975
68import into cell (GO:0098657)3.48513858
69O-glycan processing (GO:0016266)3.47226289
70regulation of lipoprotein metabolic process (GO:0050746)3.44993582
71left/right pattern formation (GO:0060972)3.42410288
72membrane tubulation (GO:0097320)3.40631845
73acyl-CoA biosynthetic process (GO:0071616)3.38513001
74thioester biosynthetic process (GO:0035384)3.38513001
75negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.36703649
76regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.34781748
77phosphate ion homeostasis (GO:0055062)3.34303970
78trivalent inorganic anion homeostasis (GO:0072506)3.34303970
79protein autoprocessing (GO:0016540)3.34043468
80GPI anchor biosynthetic process (GO:0006506)3.32158534
81presynaptic membrane organization (GO:0097090)3.30942043
82protein palmitoylation (GO:0018345)3.30632726
83NADH metabolic process (GO:0006734)3.28512018
84sphingomyelin metabolic process (GO:0006684)3.26402666
85transcytosis (GO:0045056)3.24973435
86digestion (GO:0007586)3.24225722
87iron coordination entity transport (GO:1901678)3.23426478
88GPI anchor metabolic process (GO:0006505)3.23270026
89renal absorption (GO:0070293)3.20087282
90lung epithelium development (GO:0060428)3.19566461
91negative regulation of humoral immune response (GO:0002921)3.15878568
92erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.14452573
93L-phenylalanine metabolic process (GO:0006558)3.14452573
94amyloid precursor protein catabolic process (GO:0042987)3.12903299
95glutathione biosynthetic process (GO:0006750)3.12801796
96magnesium ion transport (GO:0015693)3.12552189
97glycosylceramide metabolic process (GO:0006677)3.10375821
98regulation of autophagic vacuole assembly (GO:2000785)3.08861220
99primary alcohol metabolic process (GO:0034308)3.08643775
100limb bud formation (GO:0060174)3.08579684
101negative regulation of cell fate commitment (GO:0010454)3.06543068
102neuron remodeling (GO:0016322)3.04838424
103pyrimidine-containing compound transmembrane transport (GO:0072531)3.04461793
104protein neddylation (GO:0045116)3.04431350
105nucleotide transmembrane transport (GO:1901679)3.04086363
106preassembly of GPI anchor in ER membrane (GO:0016254)3.01918006
107glutathione derivative metabolic process (GO:1901685)2.98853162
108glutathione derivative biosynthetic process (GO:1901687)2.98853162
109axon development (GO:0061564)2.98789601
110negative regulation of axonogenesis (GO:0050771)2.98536429
111negative regulation of JUN kinase activity (GO:0043508)2.97930684
112positive regulation of pseudopodium assembly (GO:0031274)2.96870265
113negative regulation of transcription by competitive promoter binding (GO:0010944)2.96773911
114cellular response to reactive nitrogen species (GO:1902170)2.96605566
115excretion (GO:0007588)2.95675790
116negative regulation of cell fate specification (GO:0009996)2.95273933
117adhesion of symbiont to host (GO:0044406)2.94807190
118establishment of monopolar cell polarity (GO:0061162)2.93761847
119establishment or maintenance of monopolar cell polarity (GO:0061339)2.93761847
120phosphate ion transmembrane transport (GO:0035435)2.93257728
121toxin transport (GO:1901998)2.92393915
122nonribosomal peptide biosynthetic process (GO:0019184)2.89779253
123positive regulation of cellular amine metabolic process (GO:0033240)2.89118152
124presynaptic membrane assembly (GO:0097105)2.86952160
125cell-cell junction assembly (GO:0007043)2.85537239
126sperm capacitation (GO:0048240)2.84561822
127GDP-mannose metabolic process (GO:0019673)2.83568541
128phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.82492561
129response to lead ion (GO:0010288)2.82119162
130epoxygenase P450 pathway (GO:0019373)2.80368401
131oligosaccharide biosynthetic process (GO:0009312)2.79788273
132retinol metabolic process (GO:0042572)2.79236296
133establishment of skin barrier (GO:0061436)2.78935663
134adult walking behavior (GO:0007628)2.78000658
135cerebral cortex radially oriented cell migration (GO:0021799)2.76248898
136peripheral nervous system development (GO:0007422)2.75586388
137auditory receptor cell differentiation (GO:0042491)2.75464291
138proline metabolic process (GO:0006560)2.74392161
139prostanoid biosynthetic process (GO:0046457)2.73629364
140prostaglandin biosynthetic process (GO:0001516)2.73629364
141carnitine metabolic process (GO:0009437)2.73465246
142peptide catabolic process (GO:0043171)2.73078028
143mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.72726204
144peptidyl-cysteine modification (GO:0018198)2.71596258
145phenol-containing compound catabolic process (GO:0019336)2.71411553
146cytoskeletal anchoring at plasma membrane (GO:0007016)2.71255909
147angiotensin maturation (GO:0002003)2.71161900
148regulation of cholesterol biosynthetic process (GO:0045540)2.68987938
149neural nucleus development (GO:0048857)2.67568282
150protein retention in ER lumen (GO:0006621)2.65718163
151epithelial cell-cell adhesion (GO:0090136)2.65350331
152interleukin-6-mediated signaling pathway (GO:0070102)2.64968109
153response to nitric oxide (GO:0071731)2.64752887
154peptide biosynthetic process (GO:0043043)2.64735055
155Golgi transport vesicle coating (GO:0048200)2.64597105
156COPI coating of Golgi vesicle (GO:0048205)2.64597105
157positive regulation of Cdc42 GTPase activity (GO:0043089)2.64418741
158regulation of cholesterol metabolic process (GO:0090181)2.63954224
159negative regulation of T cell differentiation in thymus (GO:0033085)2.63443132
160cellular response to epinephrine stimulus (GO:0071872)2.63177042
161neurotransmitter biosynthetic process (GO:0042136)2.61464755
162hydrogen peroxide catabolic process (GO:0042744)2.61380366
163positive regulation of glial cell differentiation (GO:0045687)2.60353437
164cholesterol metabolic process (GO:0008203)2.59867406
165intestinal absorption (GO:0050892)2.59290973
166enteric nervous system development (GO:0048484)2.59154673
167negative regulation of axon extension (GO:0030517)2.58666778
168ear development (GO:0043583)2.58189581
169renal system process involved in regulation of blood volume (GO:0001977)2.58070137
170glial cell development (GO:0021782)2.57915281
171phosphate ion transport (GO:0006817)2.57119324
172amino acid import (GO:0043090)2.56831939
173glutathione metabolic process (GO:0006749)2.56807286
174organ growth (GO:0035265)2.56759838
175negative regulation of acute inflammatory response (GO:0002674)2.56665184
176regulation of pseudopodium assembly (GO:0031272)2.56222455
177thioester metabolic process (GO:0035383)2.55195024
178acyl-CoA metabolic process (GO:0006637)2.55195024
179vitamin transport (GO:0051180)2.54826734
180negative regulation of execution phase of apoptosis (GO:1900118)2.54596491
181positive regulation of action potential (GO:0045760)2.52195196
182calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.51604320
183regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.51329339
184gap junction assembly (GO:0016264)2.50861007
185leukocyte migration involved in inflammatory response (GO:0002523)2.50124780
186L-ascorbic acid metabolic process (GO:0019852)2.48853109
187regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.47354295
188central nervous system myelination (GO:0022010)12.0041662
189axon ensheathment in central nervous system (GO:0032291)12.0041662

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_21235772_ChIP-Seq_MCF-7_Human4.14687349
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.65763444
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.51144114
4CDX2_20551321_ChIP-Seq_CACO-2_Human3.06931023
5TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.91490666
6ZNF263_19887448_ChIP-Seq_K562_Human2.84885017
7SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.74593763
8* RACK7_27058665_Chip-Seq_MCF-7_Human2.67262922
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.62175662
10FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.59212459
11GBX2_23144817_ChIP-Seq_PC3_Human2.57870843
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.31495043
13RUNX1_27514584_Chip-Seq_MCF-7_Human2.19320497
14TAF15_26573619_Chip-Seq_HEK293_Human2.12147236
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07168351
16GATA4_25053715_ChIP-Seq_YYC3_Human2.01103069
17OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.96557263
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.95987363
19* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.94906015
20KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.94841894
21* GATA6_25053715_ChIP-Seq_YYC3_Human1.90662679
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.88347883
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.87451586
24VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.87290216
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82624106
26RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80240360
27AR_21572438_ChIP-Seq_LNCaP_Human1.79363292
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.77509776
29VDR_22108803_ChIP-Seq_LS180_Human1.76711798
30* LXR_22292898_ChIP-Seq_THP-1_Human1.75229783
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74181538
32P63_26484246_Chip-Seq_KERATINOCYTES_Human1.74113350
33GATA3_24758297_ChIP-Seq_MCF-7_Human1.73589145
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72385199
35KLF5_25053715_ChIP-Seq_YYC3_Human1.70532835
36* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.69046296
37* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.68721577
38* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.68039534
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.66780080
40CLOCK_20551151_ChIP-Seq_293T_Human1.66335738
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.65187413
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.65187413
43* CREB1_26743006_Chip-Seq_LNCaP_Human1.65011470
44AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.64571897
45* EZH2_27304074_Chip-Seq_ESCs_Mouse1.63991983
46* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63229690
47* EZH2_27294783_Chip-Seq_ESCs_Mouse1.61386876
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.61371648
49ER_23166858_ChIP-Seq_MCF-7_Human1.60427006
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60024915
51PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59476730
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56409180
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56408076
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.55609119
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54936160
56* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.50867742
57* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50360664
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.49289581
59SMC4_20622854_ChIP-Seq_HELA_Human1.47395605
60TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.44142964
61* CTCF_27219007_Chip-Seq_Bcells_Human1.43171857
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36484539
63* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.34461769
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31480003
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.31191634
66FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.30873508
67DROSHA_22980978_ChIP-Seq_HELA_Human1.30601917
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.30569587
69TP63_22573176_ChIP-Seq_HFKS_Human1.29790121
70WT1_19549856_ChIP-ChIP_CCG9911_Human1.29494263
71HTT_18923047_ChIP-ChIP_STHdh_Human1.28706291
72NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28345504
73NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28345504
74CBX2_27304074_Chip-Seq_ESCs_Mouse1.26805343
75PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.26719233
76HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.26480264
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26368781
78RNF2_27304074_Chip-Seq_ESCs_Mouse1.25277198
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.24295223
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.23767219
81EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.22947531
82TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22282439
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.20494569
84EOMES_21245162_ChIP-Seq_HESCs_Human1.18850972
85CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.17820076
86STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17394013
87CHD1_26751641_Chip-Seq_LNCaP_Human1.17266373
88TRIM28_21343339_ChIP-Seq_HEK293_Human1.17010992
89SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16441600
90BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.16112590
91RAD21_21589869_ChIP-Seq_MESCs_Mouse1.15317958
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.14734589
93* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14094263
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.13908746
95SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.12833545
96ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12213846
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10735577
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09644723
99AR_21909140_ChIP-Seq_LNCAP_Human1.08360142
100* ATF3_27146783_Chip-Seq_COLON_Human1.08078959
101THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.07852178
102TET1_21451524_ChIP-Seq_MESCs_Mouse1.07739949
103SA1_27219007_Chip-Seq_ERYTHROID_Human1.07604670
104GATA1_26923725_Chip-Seq_HPCs_Mouse1.07160205
105SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06351938
106SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.06054781
107* SA1_27219007_Chip-Seq_Bcells_Human1.05328571
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04538322
109SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.04277780
110PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03929301
111SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.03898235
112KAP1_27257070_Chip-Seq_ESCs_Mouse1.03311652
113P68_20966046_ChIP-Seq_HELA_Human1.02680729
114KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02599738
115TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02526950
116FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02075314
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01743265
118CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01676202
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.01260483
120* TET1_21490601_ChIP-Seq_MESCs_Mouse1.01046497
121LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00555841
122FOXA2_19822575_ChIP-Seq_HepG2_Human1.00330095
123P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99304132
124STAT1_20625510_ChIP-Seq_HELA_Human0.98827644
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.98707073
126SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.98450515
127SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.98450515
128* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97746539
129ELF5_23300383_ChIP-Seq_T47D_Human0.97708794
130* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.96590659
131P300_19829295_ChIP-Seq_ESCs_Human0.95513412
132RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95113028
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.94613991
134PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93937390
135ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93629098
136* RARB_27405468_Chip-Seq_BRAIN_Mouse0.93123152
137NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93061446
138NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.91910649
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91837250
140ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.91270635
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.91150836
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.90612822
143TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89757303
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89519210
145FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.88770214
146LXR_22158963_ChIP-Seq_LIVER_Mouse0.87685645
147FUS_26573619_Chip-Seq_HEK293_Human0.87559592
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.87410594
149CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86875717
150GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.86772305
151KDM2B_26808549_Chip-Seq_K562_Human0.86679760
152* SOX2_19829295_ChIP-Seq_ESCs_Human0.86399192
153* NANOG_19829295_ChIP-Seq_ESCs_Human0.86399192
154IRF1_19129219_ChIP-ChIP_H3396_Human0.85806526
155RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.85151945
156AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.84694326
157RARB_24833708_ChIP-Seq_LIVER_Mouse0.84579145
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.84480061
159ESR1_15608294_ChIP-ChIP_MCF-7_Human0.84249844
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83787297
161ERG_21242973_ChIP-ChIP_JURKAT_Human0.83732430
162P300_18555785_Chip-Seq_ESCs_Mouse0.83045250
163* CTCF_20526341_ChIP-Seq_ESCs_Human0.82973816
164GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82557121
165LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82406017
166* SOX2_20726797_ChIP-Seq_SW620_Human0.81948344
167NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.81749921
168AHR_22903824_ChIP-Seq_MCF-7_Human0.81190213
169KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.81122359
170KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.81122359
171KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.81122359
172ARNT_22903824_ChIP-Seq_MCF-7_Human0.81030267
173PRDM14_20953172_ChIP-Seq_ESCs_Human0.80655048
174ZNF217_24962896_ChIP-Seq_MCF-7_Human0.80624577
175TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80200037
176FOXA1_25552417_ChIP-Seq_VCAP_Human0.79883794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle6.22174629
2MP0000920_abnormal_myelination5.86711342
3MP0004782_abnormal_surfactant_physiolog5.27703641
4MP0003950_abnormal_plasma_membrane3.68637662
5MP0004264_abnormal_extraembryonic_tissu3.57692134
6MP0003880_abnormal_central_pattern3.51597589
7MP0003690_abnormal_glial_cell3.34691648
8MP0009780_abnormal_chondrocyte_physiolo2.99502838
9MP0004019_abnormal_vitamin_homeostasis2.87497883
10MP0004270_analgesia2.86994609
11MP0003329_amyloid_beta_deposits2.86057880
12MP0004885_abnormal_endolymph2.80109193
13MP0003806_abnormal_nucleotide_metabolis2.76330394
14MP0001529_abnormal_vocalization2.55393121
15MP0010352_gastrointestinal_tract_polyps2.47123502
16MP0005171_absent_coat_pigmentation2.44563365
17MP0004742_abnormal_vestibular_system2.42195523
18MP0003634_abnormal_glial_cell2.37426734
19MP0010678_abnormal_skin_adnexa2.25922918
20MP0005451_abnormal_body_composition2.23781337
21MP0005365_abnormal_bile_salt2.22458457
22MP0002098_abnormal_vibrissa_morphology2.22079815
23MP0000383_abnormal_hair_follicle2.21889749
24MP0001905_abnormal_dopamine_level2.21344039
25MP0002272_abnormal_nervous_system2.18496904
26MP0004381_abnormal_hair_follicle2.14444131
27MP0003136_yellow_coat_color2.14206751
28MP0001485_abnormal_pinna_reflex2.11404713
29MP0009379_abnormal_foot_pigmentation2.09765348
30MP0004142_abnormal_muscle_tone2.09373988
31MP0003195_calcinosis2.07438681
32MP0000462_abnormal_digestive_system2.07154810
33MP0001486_abnormal_startle_reflex2.05503151
34MP0000678_abnormal_parathyroid_gland1.96137224
35MP0004043_abnormal_pH_regulation1.93707603
36MP0003632_abnormal_nervous_system1.92347591
37MP0002229_neurodegeneration1.85941862
38MP0000778_abnormal_nervous_system1.84036723
39MP0001765_abnormal_ion_homeostasis1.80651184
40MP0001958_emphysema1.80180404
41MP0005409_darkened_coat_color1.79635122
42MP0002064_seizures1.77551922
43MP0002909_abnormal_adrenal_gland1.76528557
44MP0002277_abnormal_respiratory_mucosa1.76068493
45MP0005410_abnormal_fertilization1.74934063
46MP0005377_hearing/vestibular/ear_phenot1.74266757
47MP0003878_abnormal_ear_physiology1.74266757
48MP0001664_abnormal_digestion1.71140036
49MP0008260_abnormal_autophagy1.69926752
50MP0000604_amyloidosis1.59525878
51MP0009643_abnormal_urine_homeostasis1.57061352
52MP0003879_abnormal_hair_cell1.55240508
53MP0009840_abnormal_foam_cell1.54341590
54MP0000566_synostosis1.49923399
55MP0005501_abnormal_skin_physiology1.46827948
56MP0005636_abnormal_mineral_homeostasis1.43566170
57MP0004858_abnormal_nervous_system1.42729201
58MP0008004_abnormal_stomach_pH1.42101304
59MP0001756_abnormal_urination1.41084644
60MP0002653_abnormal_ependyma_morphology1.39282435
61MP0004147_increased_porphyrin_level1.39151014
62MP0008995_early_reproductive_senescence1.38830268
63MP0003941_abnormal_skin_development1.37707299
64MP0003631_nervous_system_phenotype1.37302998
65MP0005423_abnormal_somatic_nervous1.35499944
66MP0000647_abnormal_sebaceous_gland1.34294074
67MP0001346_abnormal_lacrimal_gland1.34203759
68MP0005058_abnormal_lysosome_morphology1.33251273
69MP0002254_reproductive_system_inflammat1.31387160
70MP0001881_abnormal_mammary_gland1.29986643
71MP0005408_hypopigmentation1.29456790
72MP0005551_abnormal_eye_electrophysiolog1.28038809
73MP0004134_abnormal_chest_morphology1.25200840
74MP0002876_abnormal_thyroid_physiology1.24189103
75MP0000747_muscle_weakness1.22327198
76MP0000579_abnormal_nail_morphology1.19766195
77MP0009745_abnormal_behavioral_response1.19495066
78MP0000955_abnormal_spinal_cord1.19197758
79MP0002734_abnormal_mechanical_nocicepti1.17718210
80MP0002132_abnormal_respiratory_system1.17042375
81MP0003866_abnormal_defecation1.15908409
82MP0009046_muscle_twitch1.15490715
83MP0000762_abnormal_tongue_morphology1.14695524
84MP0004859_abnormal_synaptic_plasticity1.14577410
85MP0002882_abnormal_neuron_morphology1.13752384
86MP0003191_abnormal_cellular_cholesterol1.12229456
87MP0010155_abnormal_intestine_physiology1.11864199
88MP0000627_abnormal_mammary_gland1.10458154
89MP0003633_abnormal_nervous_system1.09586765
90MP0000377_abnormal_hair_follicle1.09248277
91MP0001661_extended_life_span1.07676531
92MP0005083_abnormal_biliary_tract1.07292211
93MP0001666_abnormal_nutrient_absorption1.07076140
94MP0005220_abnormal_exocrine_pancreas1.05605439
95MP0002295_abnormal_pulmonary_circulatio1.05439057
96MP0002066_abnormal_motor_capabilities/c1.05347344
97MP0001963_abnormal_hearing_physiology1.03679636
98MP0001440_abnormal_grooming_behavior1.03604211
99MP0001851_eye_inflammation1.01781868
100MP0005360_urolithiasis1.01132674
101MP0000477_abnormal_intestine_morphology1.00600777
102MP0003635_abnormal_synaptic_transmissio0.99570928
103MP0002752_abnormal_somatic_nervous0.99210428
104MP0008875_abnormal_xenobiotic_pharmacok0.98847132
105MP0002796_impaired_skin_barrier0.97999674
106MP0001944_abnormal_pancreas_morphology0.97546903
107MP0003566_abnormal_cell_adhesion0.97385215
108MP0001216_abnormal_epidermal_layer0.97320073
109MP0000467_abnormal_esophagus_morphology0.96364654
110MP0002136_abnormal_kidney_physiology0.94563074
111MP0000537_abnormal_urethra_morphology0.94043398
112MP0005332_abnormal_amino_acid0.93333951
113MP0008569_lethality_at_weaning0.92929333
114MP0005195_abnormal_posterior_eye0.92869552
115MP0000681_abnormal_thyroid_gland0.90925673
116MP0003638_abnormal_response/metabolism_0.90861431
117MP0005166_decreased_susceptibility_to0.89818313
118MP0006082_CNS_inflammation0.89782338
119MP0002139_abnormal_hepatobiliary_system0.88846307
120MP0001727_abnormal_embryo_implantation0.87661776
121MP0002572_abnormal_emotion/affect_behav0.86984126
122MP0002168_other_aberrant_phenotype0.86193483
123MP0000013_abnormal_adipose_tissue0.85438260
124MP0004924_abnormal_behavior0.85293855
125MP0005386_behavior/neurological_phenoty0.85293855
126MP0001873_stomach_inflammation0.85264445
127MP0002118_abnormal_lipid_homeostasis0.84790127
128MP0010771_integument_phenotype0.84196829
129MP0001970_abnormal_pain_threshold0.83817340
130MP0003937_abnormal_limbs/digits/tail_de0.83488769
131MP0003938_abnormal_ear_development0.82720782
132MP0001299_abnormal_eye_distance/0.81989375
133MP0005165_increased_susceptibility_to0.81832848
134MP0002822_catalepsy0.81631221
135MP0001849_ear_inflammation0.81329880
136MP0003183_abnormal_peptide_metabolism0.81195142
137MP0005388_respiratory_system_phenotype0.80095038
138MP0002133_abnormal_respiratory_system0.80095038
139MP0001177_atelectasis0.78981059
140MP0005623_abnormal_meninges_morphology0.78816098
141MP0004185_abnormal_adipocyte_glucose0.78341011
142MP0000538_abnormal_urinary_bladder0.77255817
143MP0005395_other_phenotype0.75811250
144MP0003075_altered_response_to0.74987724
145MP0005381_digestive/alimentary_phenotyp0.73931859
146MP0002067_abnormal_sensory_capabilities0.73391486
147MP0005085_abnormal_gallbladder_physiolo0.72804575
148MP0005645_abnormal_hypothalamus_physiol0.70387773
149MP0002063_abnormal_learning/memory/cond0.69702062
150MP0002249_abnormal_larynx_morphology0.69385023
151MP0003953_abnormal_hormone_level0.69133618
152MP0000470_abnormal_stomach_morphology0.67361360
153MP0003453_abnormal_keratinocyte_physiol0.67051654
154MP0008438_abnormal_cutaneous_collagen0.66708694
155MP0003123_paternal_imprinting0.66389219
156MP0000026_abnormal_inner_ear0.66371838
157MP0005023_abnormal_wound_healing0.66008611
158MP0005076_abnormal_cell_differentiation0.64096888
159MP0001663_abnormal_digestive_system0.63367456
160MP0003045_fibrosis0.62969687
161MP0001340_abnormal_eyelid_morphology0.62322670
162MP0002733_abnormal_thermal_nociception0.61225001
163MP0002138_abnormal_hepatobiliary_system0.61132929
164MP0000003_abnormal_adipose_tissue0.60820921
165MP0003656_abnormal_erythrocyte_physiolo0.60711262
166MP0001984_abnormal_olfaction0.60337462
167MP0002152_abnormal_brain_morphology0.59527237
168MP0005584_abnormal_enzyme/coenzyme_acti0.58493884
169MP0004133_heterotaxia0.57524356
170MP0000613_abnormal_salivary_gland0.55919032

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.80583673
2Chronic bronchitis (HP:0004469)7.00496836
3Rhinitis (HP:0012384)6.94768865
4Abnormal respiratory epithelium morphology (HP:0012253)6.90905998
5Abnormal respiratory motile cilium morphology (HP:0005938)6.90905998
6Abnormal respiratory motile cilium physiology (HP:0012261)6.82731451
7Abnormal ciliary motility (HP:0012262)6.56259346
8Neurofibrillary tangles (HP:0002185)5.93423961
9Dynein arm defect of respiratory motile cilia (HP:0012255)5.90757837
10Absent/shortened dynein arms (HP:0200106)5.90757837
11Degeneration of the lateral corticospinal tracts (HP:0002314)5.86470821
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.86470821
13Hyperactive renin-angiotensin system (HP:0000841)5.86451565
14Interstitial pulmonary disease (HP:0006530)5.54674454
15Parakeratosis (HP:0001036)5.50390604
16Bronchiectasis (HP:0002110)5.24372472
17Sensory axonal neuropathy (HP:0003390)5.19005031
18Peripheral hypomyelination (HP:0007182)4.55890280
19Nasal polyposis (HP:0100582)4.52093799
20Cerebral hypomyelination (HP:0006808)4.49317016
21Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.34824924
22Abnormality of the corticospinal tract (HP:0002492)4.33549590
23Cerebral inclusion bodies (HP:0100314)4.23151054
24Abnormality of the nasal mucosa (HP:0000433)3.99662773
25Onion bulb formation (HP:0003383)3.72209396
26Renal salt wasting (HP:0000127)3.65293634
27Decreased circulating renin level (HP:0003351)3.59455260
28Abnormal auditory evoked potentials (HP:0006958)3.50063556
29Abnormality of renin-angiotensin system (HP:0000847)3.46095299
30Congenital ichthyosiform erythroderma (HP:0007431)3.44670067
31Leukodystrophy (HP:0002415)3.38672165
32Abnormality of glycolysis (HP:0004366)3.36791308
33Increased serum pyruvate (HP:0003542)3.36791308
34Abnormality of glutamine family amino acid metabolism (HP:0010902)3.28574993
35Intention tremor (HP:0002080)3.28350113
36Supranuclear gaze palsy (HP:0000605)3.26426417
37Alacrima (HP:0000522)3.24139338
38Pili torti (HP:0003777)3.20863397
39Spastic paraparesis (HP:0002313)3.18631719
40Spastic gait (HP:0002064)3.11242066
41Bronchitis (HP:0012387)3.10089500
42Infertility (HP:0000789)3.05888075
43Hyperaldosteronism (HP:0000859)3.00875333
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.99566972
45Dysmetria (HP:0001310)2.86361735
46CNS hypomyelination (HP:0003429)2.85174484
47Male infertility (HP:0003251)2.78644734
48Abnormality of chloride homeostasis (HP:0011422)2.77906047
49Termporal pattern (HP:0011008)2.76762841
50Insidious onset (HP:0003587)2.76762841
51Right ventricular cardiomyopathy (HP:0011663)2.76686976
52Tubulointerstitial fibrosis (HP:0005576)2.76390432
53Hyperphosphatemia (HP:0002905)2.76191783
54Hydroxyprolinuria (HP:0003080)2.73865358
55Abnormality of proline metabolism (HP:0010907)2.73865358
56Gout (HP:0001997)2.72958653
57Slow saccadic eye movements (HP:0000514)2.67096928
58Abnormality of aromatic amino acid family metabolism (HP:0004338)2.66998440
59Malnutrition (HP:0004395)2.66496859
60Premature skin wrinkling (HP:0100678)2.63534474
61Abnormality of monocarboxylic acid metabolism (HP:0010996)2.61882511
62Hypoplastic pelvis (HP:0008839)2.60231886
63Increased circulating renin level (HP:0000848)2.60214239
64Segmental peripheral demyelination/remyelination (HP:0003481)2.58046306
65Anteriorly placed anus (HP:0001545)2.56321457
66Stridor (HP:0010307)2.55416678
67Chronic sinusitis (HP:0011109)2.53744958
68Scanning speech (HP:0002168)2.51924076
69Decreased lacrimation (HP:0000633)2.51214751
70Vascular calcification (HP:0004934)2.45366413
71Fat malabsorption (HP:0002630)2.45169285
72Renal Fanconi syndrome (HP:0001994)2.44928022
73Ileus (HP:0002595)2.43136515
74Cerebral hemorrhage (HP:0001342)2.42876017
75Atelectasis (HP:0100750)2.42246251
76Hyperkalemia (HP:0002153)2.42168111
77Akinesia (HP:0002304)2.41098278
78Ankle clonus (HP:0011448)2.41016930
79Flat acetabular roof (HP:0003180)2.39378610
80Thickened helices (HP:0000391)2.37014121
81Morphological abnormality of the inner ear (HP:0011390)2.35947918
82Metabolic alkalosis (HP:0200114)2.35119610
83Methylmalonic acidemia (HP:0002912)2.34055100
84Myokymia (HP:0002411)2.32900659
85Clumsiness (HP:0002312)2.32630355
86Split foot (HP:0001839)2.32534625
87Erythroderma (HP:0001019)2.32475852
88Hyponatremia (HP:0002902)2.31112398
89Steatorrhea (HP:0002570)2.30847450
90Hypomagnesemia (HP:0002917)2.30452158
91Intrahepatic cholestasis (HP:0001406)2.30233772
92Paraparesis (HP:0002385)2.27725657
93Hepatosplenomegaly (HP:0001433)2.27047701
94Infantile muscular hypotonia (HP:0008947)2.26398248
95Amelogenesis imperfecta (HP:0000705)2.25766590
96Axonal loss (HP:0003447)2.24436410
97Abnormal hair laboratory examination (HP:0003328)2.23814613
98Distal lower limb muscle weakness (HP:0009053)2.23406668
99Abnormality of permanent molar morphology (HP:0011071)2.22081506
100Abnormality of the dental root (HP:0006486)2.22081506
101Taurodontia (HP:0000679)2.22081506
102Patchy hypopigmentation of hair (HP:0011365)2.21353492
103White forelock (HP:0002211)2.20514048
104Absent septum pellucidum (HP:0001331)2.19666887
105Hypokalemic alkalosis (HP:0001949)2.19272803
106Recurrent otitis media (HP:0000403)2.19148701
107Retinal dysplasia (HP:0007973)2.18966322
108Spastic tetraparesis (HP:0001285)2.17446107
109Acute encephalopathy (HP:0006846)2.15202743
110Autoamputation (HP:0001218)2.12890464
111Acute necrotizing encephalopathy (HP:0006965)2.12643692
112Bell-shaped thorax (HP:0001591)2.11840419
113Recurrent sinusitis (HP:0011108)2.09827930
114Abnormality of the phalanges of the 2nd finger (HP:0009541)2.09509602
115Tachypnea (HP:0002789)2.09338426
116Hypophosphatemic rickets (HP:0004912)2.07501762
117Hypoplasia of the iris (HP:0007676)2.06102064
118Coronal craniosynostosis (HP:0004440)2.06097978
119Respiratory distress (HP:0002098)2.05107899
120Hyperlipoproteinemia (HP:0010980)2.02774603
121Hypotension (HP:0002615)2.02177192
122Abnormality of the dental pulp (HP:0006479)2.01524608
123Esophageal atresia (HP:0002032)2.01091296
124Abnormality of the distal phalanges of the toes (HP:0010182)2.00046202
125Alkalosis (HP:0001948)1.99957039
126Abnormality of molar (HP:0011077)1.99615685
127Abnormality of molar morphology (HP:0011070)1.99615685
128Partial duplication of thumb phalanx (HP:0009944)1.99209234
129Growth hormone excess (HP:0000845)1.96550449
130Hypokinesia (HP:0002375)1.96134132
131Cardiovascular calcification (HP:0011915)1.95511203
132Abnormality of vitamin metabolism (HP:0100508)1.95452126
133Hyperglycinuria (HP:0003108)1.94924216
134Villous atrophy (HP:0011473)1.94714455
135Abnormality of small intestinal villus morphology (HP:0011472)1.94714455
136Abdominal distention (HP:0003270)1.94074996
137Abnormality of the middle phalanges of the toes (HP:0010183)1.93991084
138Peripheral demyelination (HP:0011096)1.93752738
139Spinal cord compression (HP:0002176)1.93237115
140Pheochromocytoma (HP:0002666)1.91163905
141Muscle fiber splitting (HP:0003555)1.90289604
142Foot dorsiflexor weakness (HP:0009027)1.89662773
143Chronic otitis media (HP:0000389)1.89409142
144Bronchomalacia (HP:0002780)1.87918727
145Abnormality of sodium homeostasis (HP:0010931)1.87862975
146Aplasia involving bones of the upper limbs (HP:0009823)1.87735440
147Aplasia of the phalanges of the hand (HP:0009802)1.87735440
148Aplasia involving bones of the extremities (HP:0009825)1.87735440
149Choreoathetosis (HP:0001266)1.87233560
150Abnormality of the septum pellucidum (HP:0007375)1.85991173
151Poor speech (HP:0002465)1.83543871
1523-Methylglutaconic aciduria (HP:0003535)1.80100050
153Synostosis involving the elbow (HP:0003938)1.80052682
154Humeroradial synostosis (HP:0003041)1.80052682
155Megalencephaly (HP:0001355)1.79895256
156Adrenal overactivity (HP:0002717)1.79214486
157Abnormality of magnesium homeostasis (HP:0004921)1.78205011
158Prolonged neonatal jaundice (HP:0006579)1.77774997
159Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77189326
160Cupped ear (HP:0000378)1.77085727
161Hyporeflexia of lower limbs (HP:0002600)1.76949112
162Mitochondrial inheritance (HP:0001427)1.76921054
163Bifid scrotum (HP:0000048)1.76645925
164Abnormality of the salivary glands (HP:0010286)1.76331009
165Decreased motor nerve conduction velocity (HP:0003431)1.73850300
166Hepatocellular necrosis (HP:0001404)1.73724619
167Stenosis of the external auditory canal (HP:0000402)1.72906728
168Hyperparathyroidism (HP:0000843)1.72735241
169Hyperuricemia (HP:0002149)1.71301852
170Increased purine levels (HP:0004368)1.71301852
171Bowel incontinence (HP:0002607)1.71011498
172Tubulointerstitial abnormality (HP:0001969)1.70996973
173Cystic liver disease (HP:0006706)1.69697730
174Clonus (HP:0002169)1.69297777
175Abnormality of the foot musculature (HP:0001436)1.68627082
176Partial agenesis of the corpus callosum (HP:0001338)1.68547380
177Abnormal mitochondria in muscle tissue (HP:0008316)1.68235328
178Tubular atrophy (HP:0000092)1.67834971
179Tubulointerstitial nephritis (HP:0001970)1.67506882
180Germ cell neoplasia (HP:0100728)1.63237316
181Abnormality of renal excretion (HP:0011036)1.62035844
182Abnormality of serine family amino acid metabolism (HP:0010894)1.61679007
183Abnormality of glycine metabolism (HP:0010895)1.61679007
184Popliteal pterygium (HP:0009756)1.59471000
185Goiter (HP:0000853)1.57666483
186Occipital encephalocele (HP:0002085)1.57581379
187Short nail (HP:0001799)1.57126732
188Ventricular fibrillation (HP:0001663)1.56851781
189Hyperthyroidism (HP:0000836)1.56725478
190Glomerulosclerosis (HP:0000096)1.55966143
191Glucose intolerance (HP:0000833)1.55662414
192Hypoglycemic seizures (HP:0002173)1.55586159
193Abnormal glucose tolerance (HP:0001952)1.51719491
194Symptomatic seizures (HP:0011145)1.49790871

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.47428622
2OXSR14.82163712
3EPHB13.71811206
4MST1R3.60952213
5BCR3.24560174
6MET2.82477375
7PKN12.80658898
8WNK42.75832181
9SMG12.62387204
10CDK192.58156363
11PBK2.53038420
12TRIB32.48928280
13FGFR22.34386539
14MAPKAPK52.28938391
15LMTK22.28382059
16TESK12.24677549
17CSNK1G32.15230810
18MAPKAPK32.14811501
19CSNK1A1L2.07943896
20LIMK12.04166966
21TESK22.01017618
22RIPK11.94305006
23FER1.91762050
24SIK11.91605640
25MAP3K121.86187332
26NEK61.73976045
27PAK41.71767091
28CSNK1G11.69080912
29WNK11.68341361
30TNIK1.66411473
31PRPF4B1.64385159
32UHMK11.64135449
33CAMK2B1.63712760
34RPS6KB21.61643811
35STK241.61421793
36MST41.57805871
37CSNK1G21.56383407
38ROCK21.50520538
39STK381.48311421
40ICK1.39717952
41CAMK2D1.39498151
42LATS21.38218806
43MAP3K31.37300301
44NTRK11.36588512
45PNCK1.34543574
46FGR1.31312785
47PTK61.26497031
48FGFR41.24118463
49PRKCI1.22065797
50CLK11.20598644
51ERN11.18606692
52PRKG21.18182788
53LRRK21.16626396
54SGK2231.16553237
55SGK4941.16553237
56PRKD31.16552783
57EPHA31.13791952
58CAMK2G1.13271029
59EEF2K1.12238439
60TAOK11.09097484
61STK38L1.05892283
62PAK61.05312255
63DYRK21.04541633
64MAPK151.03124866
65TYRO31.02886131
66EIF2AK10.99448735
67CASK0.95677874
68ILK0.93697823
69EPHA40.87884078
70ERBB40.85372232
71MYLK0.84388126
72PTK20.84252609
73PRKCQ0.81430428
74CDK140.81132997
75TTK0.80841155
76PRKD10.78862472
77TRPM70.78292516
78MAP2K20.77705314
79NLK0.74061744
80CAMK2A0.73641072
81MARK20.73502620
82MARK10.72729030
83ARAF0.69335165
84PDPK10.68695924
85CDK50.67396428
86PAK30.67274344
87CDK150.67129883
88IRAK30.64128899
89PRKCE0.63082809
90MAP2K60.62032078
91SCYL20.61264778
92CDK180.61070556
93RPS6KA20.60856377
94IRAK20.60662305
95CDK11A0.60301389
96ERBB20.58745396
97LATS10.58354160
98FGFR30.58290450
99MAP3K10.57709409
100MELK0.55301632
101FYN0.53901318
102ACVR1B0.53876890
103BMPR1B0.53329222
104TBK10.52591232
105GSK3A0.52439598
106PKN20.52298771
107HIPK20.51048938
108RPS6KA50.50263366
109BCKDK0.49081418
110CSNK1D0.47054614
111DAPK10.46728783
112PHKG10.45226208
113PHKG20.45226208
114CSNK1A10.45179870
115DMPK0.44319422
116EPHA20.43551185
117DAPK20.42502281
118YES10.42488758
119CDC42BPA0.42036374
120PAK10.41505295
121PRKG10.41335105
122PRKACB0.41036854
123MUSK0.39650334
124PRKCZ0.37817460
125STK110.37015115
126GRK70.36513097
127NME20.35727842
128DAPK30.35287981
129PIK3CA0.34684649
130MAP3K20.32821078
131PINK10.32262291
132PRKD20.32094795
133IRAK10.32082422
134PRKCA0.31318262
135NME10.31251771
136STK160.29434031
137MAP3K80.29284864
138PRKCD0.29064513
139KSR20.28988890
140PDGFRB0.28152802
141GRK10.28118238
142MAPK70.27890703
143PRKCH0.27747377
144PDK10.27417899
145ADRBK20.26390353
146SRC0.26045841
147CSNK1E0.25882317
148PRKACA0.25469357
149NTRK30.25200818
150OBSCN0.25161660
151ITK0.25126172
152ABL20.25066167
153TIE10.24356994
154INSR0.23297169
155PRKAA20.22661349
156BMX0.22150486
157MAPK130.21956540
158ALK0.20397612
159AKT30.19416008
160ROCK10.18650430
161MKNK10.18324406
162STK30.18185956
163PTK2B0.18032151
164AKT20.17939674
165MAP3K130.17669654

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.18359666
2Fatty acid elongation_Homo sapiens_hsa000624.75738711
3Steroid biosynthesis_Homo sapiens_hsa001004.70820447
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.70492989
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.97498906
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.93377933
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83471638
8Ether lipid metabolism_Homo sapiens_hsa005652.75537559
9Phenylalanine metabolism_Homo sapiens_hsa003602.75432373
10Sulfur metabolism_Homo sapiens_hsa009202.42689053
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.26632135
12Oxidative phosphorylation_Homo sapiens_hsa001902.22805051
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.06548625
14Histidine metabolism_Homo sapiens_hsa003402.05036321
15Protein export_Homo sapiens_hsa030601.98205943
16Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94630641
17Vitamin B6 metabolism_Homo sapiens_hsa007501.93164412
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92045578
19Butanoate metabolism_Homo sapiens_hsa006501.90402356
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.83477940
21Nitrogen metabolism_Homo sapiens_hsa009101.82100727
22Maturity onset diabetes of the young_Homo sapiens_hsa049501.71777161
23Caffeine metabolism_Homo sapiens_hsa002321.68916874
24Linoleic acid metabolism_Homo sapiens_hsa005911.68119253
25Sphingolipid metabolism_Homo sapiens_hsa006001.68050484
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62474174
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55575439
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.55344992
29Parkinsons disease_Homo sapiens_hsa050121.54729468
30Starch and sucrose metabolism_Homo sapiens_hsa005001.53138576
31Fructose and mannose metabolism_Homo sapiens_hsa000511.52710450
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.49244227
33Axon guidance_Homo sapiens_hsa043601.44751202
34Alzheimers disease_Homo sapiens_hsa050101.44463646
35Arginine and proline metabolism_Homo sapiens_hsa003301.42412559
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38344185
37Protein digestion and absorption_Homo sapiens_hsa049741.27785864
38Renin-angiotensin system_Homo sapiens_hsa046141.26816924
39Propanoate metabolism_Homo sapiens_hsa006401.22821223
40Glutathione metabolism_Homo sapiens_hsa004801.20784041
41Fatty acid metabolism_Homo sapiens_hsa012121.19291333
42Folate biosynthesis_Homo sapiens_hsa007901.18212366
43Galactose metabolism_Homo sapiens_hsa000521.15413801
44Sulfur relay system_Homo sapiens_hsa041221.11899849
45Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.08845755
46Carbohydrate digestion and absorption_Homo sapiens_hsa049731.06750309
47Peroxisome_Homo sapiens_hsa041461.01628530
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.01083612
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00862019
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.00136042
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98851383
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96882205
53Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96855024
54Arachidonic acid metabolism_Homo sapiens_hsa005900.95733221
55Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95716727
56Primary bile acid biosynthesis_Homo sapiens_hsa001200.94172932
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93754153
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.93385837
59Vitamin digestion and absorption_Homo sapiens_hsa049770.93109764
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91036363
61Tight junction_Homo sapiens_hsa045300.90762011
62Renal cell carcinoma_Homo sapiens_hsa052110.87710305
63Vibrio cholerae infection_Homo sapiens_hsa051100.86215688
64Chemical carcinogenesis_Homo sapiens_hsa052040.84494919
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.84224611
66Hepatitis C_Homo sapiens_hsa051600.84031933
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77817361
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77594065
69Other glycan degradation_Homo sapiens_hsa005110.77339149
70Collecting duct acid secretion_Homo sapiens_hsa049660.76676319
71Thyroid hormone synthesis_Homo sapiens_hsa049180.76473251
72Huntingtons disease_Homo sapiens_hsa050160.74562567
73Glycerophospholipid metabolism_Homo sapiens_hsa005640.74518113
74Retinol metabolism_Homo sapiens_hsa008300.73107599
75Serotonergic synapse_Homo sapiens_hsa047260.72926000
76Fat digestion and absorption_Homo sapiens_hsa049750.72791305
77GABAergic synapse_Homo sapiens_hsa047270.69663703
78Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67964237
79Mineral absorption_Homo sapiens_hsa049780.67532025
80Glutamatergic synapse_Homo sapiens_hsa047240.66290975
81Insulin secretion_Homo sapiens_hsa049110.65190605
82Lysosome_Homo sapiens_hsa041420.64802147
83Metabolic pathways_Homo sapiens_hsa011000.63008726
84Adherens junction_Homo sapiens_hsa045200.62659306
85beta-Alanine metabolism_Homo sapiens_hsa004100.62472765
86Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61529669
87Tyrosine metabolism_Homo sapiens_hsa003500.60437040
88Pyruvate metabolism_Homo sapiens_hsa006200.59845855
89Cardiac muscle contraction_Homo sapiens_hsa042600.58585571
90Pancreatic secretion_Homo sapiens_hsa049720.58097233
91Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56984083
92Insulin resistance_Homo sapiens_hsa049310.56868477
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.55601671
94Endocytosis_Homo sapiens_hsa041440.55285024
95Synaptic vesicle cycle_Homo sapiens_hsa047210.54716762
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54194609
97Sphingolipid signaling pathway_Homo sapiens_hsa040710.53978137
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.53901993
99Glycerolipid metabolism_Homo sapiens_hsa005610.51591614
100Rheumatoid arthritis_Homo sapiens_hsa053230.51189785
101Long-term depression_Homo sapiens_hsa047300.48364377
102Fatty acid degradation_Homo sapiens_hsa000710.47240134
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46041840
104Ovarian steroidogenesis_Homo sapiens_hsa049130.45941446
105Ras signaling pathway_Homo sapiens_hsa040140.43760372
106Autoimmune thyroid disease_Homo sapiens_hsa053200.43730366
107Regulation of autophagy_Homo sapiens_hsa041400.42763706
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41052279
109Amphetamine addiction_Homo sapiens_hsa050310.38164027
110Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.37792995
111Tryptophan metabolism_Homo sapiens_hsa003800.37030423
112Fatty acid biosynthesis_Homo sapiens_hsa000610.36659587
113ABC transporters_Homo sapiens_hsa020100.36428369
114Cocaine addiction_Homo sapiens_hsa050300.33822662
115Hedgehog signaling pathway_Homo sapiens_hsa043400.33506540
116PPAR signaling pathway_Homo sapiens_hsa033200.32838877
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.32639347
118Vascular smooth muscle contraction_Homo sapiens_hsa042700.32227280
119AMPK signaling pathway_Homo sapiens_hsa041520.31102440
120Phagosome_Homo sapiens_hsa041450.30993724
121Arginine biosynthesis_Homo sapiens_hsa002200.30957879
122Pentose phosphate pathway_Homo sapiens_hsa000300.29098171
123Bile secretion_Homo sapiens_hsa049760.28856794
124Thyroid cancer_Homo sapiens_hsa052160.28845626
125Morphine addiction_Homo sapiens_hsa050320.28541670
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.28402539
127Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28087317
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.26706484
129ECM-receptor interaction_Homo sapiens_hsa045120.24931703
130Phototransduction_Homo sapiens_hsa047440.24655712
131Glucagon signaling pathway_Homo sapiens_hsa049220.23996770
132ErbB signaling pathway_Homo sapiens_hsa040120.23595222
133Salivary secretion_Homo sapiens_hsa049700.23115583
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.22188967
135Notch signaling pathway_Homo sapiens_hsa043300.22028979
136Renin secretion_Homo sapiens_hsa049240.21885391
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.21526005
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.20515273
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.20099396
140Complement and coagulation cascades_Homo sapiens_hsa046100.19558628
141Malaria_Homo sapiens_hsa051440.19318016
142Circadian rhythm_Homo sapiens_hsa047100.19223088
143Insulin signaling pathway_Homo sapiens_hsa049100.19069245
144Gastric acid secretion_Homo sapiens_hsa049710.19021389
145Aldosterone synthesis and secretion_Homo sapiens_hsa049250.18832299
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17422744

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