TMEM126A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mitochondrial membrane protein of unknown function. Defects in this gene are a cause of optic atrophy type 7 (OPA7). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.79794625
2mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.52864656
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.41144399
4ATP synthesis coupled proton transport (GO:0015986)5.41144399
5protein complex biogenesis (GO:0070271)5.13980485
6respiratory electron transport chain (GO:0022904)5.01762417
7mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.95695799
8mitochondrial respiratory chain complex I assembly (GO:0032981)4.95695799
9NADH dehydrogenase complex assembly (GO:0010257)4.95695799
10polyketide metabolic process (GO:0030638)4.95461838
11doxorubicin metabolic process (GO:0044598)4.95461838
12daunorubicin metabolic process (GO:0044597)4.95461838
13ribosomal small subunit assembly (GO:0000028)4.94322001
14electron transport chain (GO:0022900)4.85053663
15mitochondrial respiratory chain complex assembly (GO:0033108)4.78110074
16regulation of mitochondrial translation (GO:0070129)4.72948077
17SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.52597843
18proteasome assembly (GO:0043248)4.50068777
19cotranslational protein targeting to membrane (GO:0006613)4.49870898
20viral transcription (GO:0019083)4.47404870
21protein targeting to ER (GO:0045047)4.43525295
22translational termination (GO:0006415)4.41497196
23tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)4.39944510
24RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)4.39944510
25establishment of protein localization to endoplasmic reticulum (GO:0072599)4.29094849
26ribosomal large subunit biogenesis (GO:0042273)4.27343844
27protein localization to endoplasmic reticulum (GO:0070972)4.19446839
28oxidative phosphorylation (GO:0006119)4.15955205
29ribosomal small subunit biogenesis (GO:0042274)4.05678294
30translation (GO:0006412)4.04311315
31cytochrome complex assembly (GO:0017004)3.92813227
32cullin deneddylation (GO:0010388)3.90021872
33translational elongation (GO:0006414)3.87173338
34maturation of SSU-rRNA (GO:0030490)3.85835997
35protein deneddylation (GO:0000338)3.84566545
36translational initiation (GO:0006413)3.72665556
37positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.63386741
38chromatin remodeling at centromere (GO:0031055)3.62817349
39CENP-A containing nucleosome assembly (GO:0034080)3.62133694
40nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61827063
41DNA deamination (GO:0045006)3.61007728
42exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.58365052
43respiratory chain complex IV assembly (GO:0008535)3.57720416
44positive regulation of ligase activity (GO:0051351)3.56114544
45protein localization to mitochondrion (GO:0070585)3.55936732
46aerobic respiration (GO:0009060)3.43244260
47chaperone-mediated protein transport (GO:0072321)3.37204093
48viral life cycle (GO:0019058)3.37015351
49deoxyribose phosphate biosynthetic process (GO:0046385)3.35502266
502-deoxyribonucleotide biosynthetic process (GO:0009265)3.35502266
51cellular protein complex disassembly (GO:0043624)3.33751841
52rRNA methylation (GO:0031167)3.32097096
53heart contraction (GO:0060047)3.29440649
54heart process (GO:0003015)3.29440649
55nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.28584341
56intracellular protein transmembrane import (GO:0044743)3.26645663
57water-soluble vitamin biosynthetic process (GO:0042364)3.22874560
58rRNA processing (GO:0006364)3.19498624
59peptidyl-histidine modification (GO:0018202)3.18112970
60ribonucleoside triphosphate biosynthetic process (GO:0009201)3.17693205
61regulation of ubiquitin-protein transferase activity (GO:0051438)3.17091350
62proton transport (GO:0015992)3.15626152
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15583023
64ribonucleoprotein complex biogenesis (GO:0022613)3.15459689
65termination of RNA polymerase III transcription (GO:0006386)3.14708229
66transcription elongation from RNA polymerase III promoter (GO:0006385)3.14708229
67aminoglycoside antibiotic metabolic process (GO:0030647)3.14405267
68mitochondrial transport (GO:0006839)3.13532509
69establishment of viral latency (GO:0019043)3.13455980
70regulation of ligase activity (GO:0051340)3.13069921
71spliceosomal snRNP assembly (GO:0000387)3.11012866
72nucleobase-containing small molecule interconversion (GO:0015949)3.10380342
73protein-cofactor linkage (GO:0018065)3.09889945
74DNA damage response, detection of DNA damage (GO:0042769)3.09120428
75quinone biosynthetic process (GO:1901663)3.08674552
76ubiquinone biosynthetic process (GO:0006744)3.08674552
77hydrogen transport (GO:0006818)3.08467094
78deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.07741951
79rRNA metabolic process (GO:0016072)3.07434799
80establishment of protein localization to mitochondrial membrane (GO:0090151)3.06278759
81deoxyribonucleoside triphosphate metabolic process (GO:0009200)3.04394390
82regulation of cellular amino acid metabolic process (GO:0006521)3.03698999
83DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.03687035
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.02714584
85histone mRNA metabolic process (GO:0008334)3.02704469
86ribosome assembly (GO:0042255)2.98106729
87cellular response to gamma radiation (GO:0071480)2.97269202
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.97119409
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97119409
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.97119409
91GTP biosynthetic process (GO:0006183)2.97062720
92DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.96151778
93intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.95686597
94signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.95686597
95nucleoside triphosphate biosynthetic process (GO:0009142)2.94325393
96L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.93708707
97ubiquinone metabolic process (GO:0006743)2.93481735
98guanosine-containing compound biosynthetic process (GO:1901070)2.92499471
99signal peptide processing (GO:0006465)2.92042579
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91248595
101protein neddylation (GO:0045116)2.90224998
102superoxide anion generation (GO:0042554)2.88636950
103antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.88539184
1047-methylguanosine mRNA capping (GO:0006370)2.88521358
105rRNA modification (GO:0000154)2.88461236
106aldehyde catabolic process (GO:0046185)2.87564987
1077-methylguanosine RNA capping (GO:0009452)2.87048149
108RNA capping (GO:0036260)2.87048149
109deoxyribonucleotide biosynthetic process (GO:0009263)2.85771671
110deoxyribonucleoside diphosphate metabolic process (GO:0009186)2.84151054
111negative regulation of mast cell activation (GO:0033004)2.83201218
112negative regulation of myeloid cell apoptotic process (GO:0033033)2.82953467
113regulation of cellular respiration (GO:0043457)2.82427999
114inner mitochondrial membrane organization (GO:0007007)2.81280330
115pseudouridine synthesis (GO:0001522)2.80665630
116mannosylation (GO:0097502)2.80551834
117regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.79593576
118signal transduction involved in cell cycle checkpoint (GO:0072395)2.77669880
119cellular respiration (GO:0045333)2.77655242
120purine nucleoside triphosphate biosynthetic process (GO:0009145)2.76973136
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.75486333
122signal transduction involved in DNA integrity checkpoint (GO:0072401)2.75486333
123purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74646026
124negative regulation of ligase activity (GO:0051352)2.69896545
125negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.69896545
126ATP biosynthetic process (GO:0006754)2.68241256
127regulation of oxidative phosphorylation (GO:0002082)2.65777850
128negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.63624167
129tRNA processing (GO:0008033)2.63020133
130pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.61586525
131establishment of protein localization to mitochondrion (GO:0072655)2.60222830
132antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.59860492
133hydrogen ion transmembrane transport (GO:1902600)2.59845042
134regulation of hexokinase activity (GO:1903299)2.59778660
135regulation of glucokinase activity (GO:0033131)2.59778660
136cellular response to oxygen radical (GO:0071450)2.57992858
137removal of superoxide radicals (GO:0019430)2.57992858
138cellular response to superoxide (GO:0071451)2.57992858
139protein targeting to mitochondrion (GO:0006626)2.57604418
140establishment of integrated proviral latency (GO:0075713)2.55874127
141cellular component biogenesis (GO:0044085)2.54669061
142ER overload response (GO:0006983)2.53006222
143anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.52997568

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.02389097
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.09671042
3EST1_17652178_ChIP-ChIP_JURKAT_Human3.74374856
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62263683
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.35538265
6SRF_21415370_ChIP-Seq_HL-1_Mouse3.31537097
7* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.06204012
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.04103566
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.90927542
10* ELK1_19687146_ChIP-ChIP_HELA_Human2.65033773
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63259371
12E2F7_22180533_ChIP-Seq_HELA_Human2.63176584
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.56055004
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.48063052
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.48044083
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41206550
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.36402650
18VDR_23849224_ChIP-Seq_CD4+_Human2.22873631
19MYC_18358816_ChIP-ChIP_MESCs_Mouse2.21746966
20FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.18439581
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15483931
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.13343664
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06534600
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03828673
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.01843709
26HOXB4_20404135_ChIP-ChIP_EML_Mouse1.97115958
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.94196323
28DCP1A_22483619_ChIP-Seq_HELA_Human1.93130004
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.89411324
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.86784635
31MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.84899129
32IRF1_19129219_ChIP-ChIP_H3396_Human1.79397841
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.77093297
34ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75629512
35EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71313439
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70980237
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68095445
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.67818902
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.66922914
40FOXP3_21729870_ChIP-Seq_TREG_Human1.62487372
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62087849
42VDR_22108803_ChIP-Seq_LS180_Human1.61510241
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.59261015
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.57076353
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.56529266
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53371972
47IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.50500537
48CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.48231168
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46189220
50ZNF274_21170338_ChIP-Seq_K562_Hela1.43748175
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.43512689
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42157325
53GABP_19822575_ChIP-Seq_HepG2_Human1.41459618
54MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40090169
55CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37016156
56PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36057478
57IRF8_22096565_ChIP-ChIP_GC-B_Human1.33047448
58* TTF2_22483619_ChIP-Seq_HELA_Human1.31323027
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31257191
60NOTCH1_21737748_ChIP-Seq_TLL_Human1.29979979
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.29958419
62MYC_19079543_ChIP-ChIP_MESCs_Mouse1.29808046
63POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29565097
64NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25536317
65MYC_18940864_ChIP-ChIP_HL60_Human1.22991885
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.22147036
67XRN2_22483619_ChIP-Seq_HELA_Human1.19808192
68* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.18369342
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.17388230
70FUS_26573619_Chip-Seq_HEK293_Human1.13992770
71FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13762966
72CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.12535487
73EWS_26573619_Chip-Seq_HEK293_Human1.11766962
74IRF8_21731497_ChIP-ChIP_J774_Mouse1.10747455
75POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10497130
76SUZ12_27294783_Chip-Seq_NPCs_Mouse1.10081771
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.09741857
78NFE2_27457419_Chip-Seq_LIVER_Mouse1.09308533
79GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.08861190
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08689776
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08250605
82STAT3_18555785_Chip-Seq_ESCs_Mouse1.05684861
83MYCN_18555785_ChIP-Seq_MESCs_Mouse1.04774309
84E2F1_21310950_ChIP-Seq_MCF-7_Human1.04601355
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03894007
86FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01446716
87IGF1R_20145208_ChIP-Seq_DFB_Human0.98941070
88TP53_22573176_ChIP-Seq_HFKS_Human0.98830681
89TP63_19390658_ChIP-ChIP_HaCaT_Human0.97814578
90PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97049557
91POU5F1_16153702_ChIP-ChIP_HESCs_Human0.94634076
92EZH2_27294783_Chip-Seq_NPCs_Mouse0.94563968
93P300_19829295_ChIP-Seq_ESCs_Human0.94508081
94FOXM1_23109430_ChIP-Seq_U2OS_Human0.93347860
95EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93311825
96SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92686098
97CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91866069
98GATA1_22025678_ChIP-Seq_K562_Human0.91828763
99SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91217641
100SOX17_20123909_ChIP-Seq_XEN_Mouse0.91098583
101NANOG_16153702_ChIP-ChIP_HESCs_Human0.90585570
102GATA4_21415370_ChIP-Seq_HL-1_Mouse0.90258505
103HTT_18923047_ChIP-ChIP_STHdh_Human0.89879415
104KAP1_22055183_ChIP-Seq_ESCs_Mouse0.89675103
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.89611804
106BMI1_23680149_ChIP-Seq_NPCS_Mouse0.89381211
107KDM5A_27292631_Chip-Seq_BREAST_Human0.88820045
108AR_21909140_ChIP-Seq_LNCAP_Human0.85031707
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.84704488
110E2F1_18555785_Chip-Seq_ESCs_Mouse0.84412833
111ZFX_18555785_ChIP-Seq_MESCs_Mouse0.84264269
112AR_20517297_ChIP-Seq_VCAP_Human0.83040143
113SALL1_21062744_ChIP-ChIP_HESCs_Human0.82950740
114MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.81962676
115E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81246115
116DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80553480
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.80419743
118FOXA1_27270436_Chip-Seq_PROSTATE_Human0.78996036
119FOXA1_25329375_ChIP-Seq_VCAP_Human0.78996036
120ELF5_23300383_ChIP-Seq_T47D_Human0.77736741
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.77296325
122ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.77278950
123SALL4_22934838_ChIP-ChIP_CD34+_Human0.76482779
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.75738046
125PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.75499348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009697_abnormal_copulation3.61420064
2MP0003186_abnormal_redox_activity3.23151613
3MP0003806_abnormal_nucleotide_metabolis2.90461222
4MP0009379_abnormal_foot_pigmentation2.81779266
5MP0006292_abnormal_olfactory_placode2.55212073
6MP0002132_abnormal_respiratory_system2.50044579
7MP0004147_increased_porphyrin_level2.49001938
8MP0006072_abnormal_retinal_apoptosis2.43383767
9MP0006036_abnormal_mitochondrial_physio2.40881007
10MP0003646_muscle_fatigue2.36342560
11MP0005646_abnormal_pituitary_gland2.24218676
12MP0008877_abnormal_DNA_methylation2.17748217
13MP0010386_abnormal_urinary_bladder2.14314796
14MP0000749_muscle_degeneration2.12213472
15MP0001986_abnormal_taste_sensitivity2.11894241
16MP0002102_abnormal_ear_morphology2.05989835
17MP0000372_irregular_coat_pigmentation2.00028733
18MP0002837_dystrophic_cardiac_calcinosis1.91386856
19MP0005503_abnormal_tendon_morphology1.90568153
20MP0002938_white_spotting1.84569982
21MP0002638_abnormal_pupillary_reflex1.82843364
22MP0003693_abnormal_embryo_hatching1.81306318
23MP0002163_abnormal_gland_morphology1.79845309
24MP0006035_abnormal_mitochondrial_morpho1.79197318
25MP0003011_delayed_dark_adaptation1.78621835
26MP0005084_abnormal_gallbladder_morpholo1.78567040
27MP0003941_abnormal_skin_development1.77931971
28MP0000015_abnormal_ear_pigmentation1.77275534
29MP0003136_yellow_coat_color1.74620223
30MP0004782_abnormal_surfactant_physiolog1.73894912
31MP0008058_abnormal_DNA_repair1.73762021
32MP0002876_abnormal_thyroid_physiology1.73333486
33MP0002148_abnormal_hypersensitivity_rea1.73040521
34MP0005379_endocrine/exocrine_gland_phen1.72877796
35MP0000566_synostosis1.69123004
36MP0001188_hyperpigmentation1.68839552
37MP0005171_absent_coat_pigmentation1.67139182
38MP0008057_abnormal_DNA_replication1.64432198
39MP0003111_abnormal_nucleus_morphology1.61846772
40MP0008007_abnormal_cellular_replicative1.61309741
41MP0009785_altered_susceptibility_to1.59067791
42MP0001529_abnormal_vocalization1.58143313
43MP0008875_abnormal_xenobiotic_pharmacok1.56261830
44MP0001835_abnormal_antigen_presentation1.53648420
45MP0003724_increased_susceptibility_to1.53067726
46MP0001764_abnormal_homeostasis1.52056377
47MP0001853_heart_inflammation1.51240796
48MP0008789_abnormal_olfactory_epithelium1.46482266
49MP0002277_abnormal_respiratory_mucosa1.44481610
50MP0004215_abnormal_myocardial_fiber1.44195939
51MP0002139_abnormal_hepatobiliary_system1.43402959
52MP0003786_premature_aging1.42607703
53MP0005253_abnormal_eye_physiology1.41336334
54MP0010094_abnormal_chromosome_stability1.35935593
55MP0008872_abnormal_physiological_respon1.33299120
56MP0005408_hypopigmentation1.28249574
57MP0005083_abnormal_biliary_tract1.24410189
58MP0003195_calcinosis1.22163131
59MP0004084_abnormal_cardiac_muscle1.21361124
60MP0005085_abnormal_gallbladder_physiolo1.21003246
61MP0008995_early_reproductive_senescence1.19770572
62MP0002090_abnormal_vision1.19288939
63MP0000358_abnormal_cell_content/1.18071916
64MP0003718_maternal_effect1.16604740
65MP0005551_abnormal_eye_electrophysiolog1.15490386
66MP0003436_decreased_susceptibility_to1.12835914
67MP0003567_abnormal_fetal_cardiomyocyte1.12814644
68MP0000631_abnormal_neuroendocrine_gland1.11532053
69MP0003950_abnormal_plasma_membrane1.11507457
70MP0001293_anophthalmia1.11199058
71MP0005671_abnormal_response_to1.10893745
72MP0009764_decreased_sensitivity_to1.10234818
73MP0000343_altered_response_to1.10213043
74MP0002210_abnormal_sex_determination1.09287698
75MP0005075_abnormal_melanosome_morpholog1.07666596
76MP0000858_altered_metastatic_potential1.07175952
77MP0002972_abnormal_cardiac_muscle1.06385154
78MP0004036_abnormal_muscle_relaxation1.06267530
79MP0002127_abnormal_cardiovascular_syste1.04498649
80MP0003279_aneurysm1.04090157
81MP0003880_abnormal_central_pattern1.03278823
82MP0005330_cardiomyopathy1.02345971
83MP0002160_abnormal_reproductive_system1.00807200
84MP0002822_catalepsy1.00741033
85MP0003077_abnormal_cell_cycle1.00367364
86MP0005389_reproductive_system_phenotype0.99366534
87MP0001929_abnormal_gametogenesis0.95122806
88MP0005670_abnormal_white_adipose0.94866005
89MP0002332_abnormal_exercise_endurance0.94743809
90MP0001119_abnormal_female_reproductive0.89399928
91MP0008932_abnormal_embryonic_tissue0.88596607
92MP0004145_abnormal_muscle_electrophysio0.88340426
93MP0001542_abnormal_bone_strength0.87971149
94MP0001905_abnormal_dopamine_level0.87643591
95MP0003123_paternal_imprinting0.87475902
96MP0002419_abnormal_innate_immunity0.87071689
97MP0001984_abnormal_olfaction0.86327897
98MP0000653_abnormal_sex_gland0.85150195
99MP0001485_abnormal_pinna_reflex0.85136337
100MP0010030_abnormal_orbit_morphology0.84313151
101MP0006054_spinal_hemorrhage0.83377196
102MP0002095_abnormal_skin_pigmentation0.83312018
103MP0003943_abnormal_hepatobiliary_system0.82495472
104MP0001145_abnormal_male_reproductive0.81643358
105MP0004133_heterotaxia0.81119597
106MP0005266_abnormal_metabolism0.80528187
107MP0005645_abnormal_hypothalamus_physiol0.80307905
108MP0005025_abnormal_response_to0.79607359
109MP0004957_abnormal_blastocyst_morpholog0.79120650
110MP0002138_abnormal_hepatobiliary_system0.78593208
111MP0005319_abnormal_enzyme/_coenzyme0.78431602
112MP0005000_abnormal_immune_tolerance0.78310056
113MP0005636_abnormal_mineral_homeostasis0.78097846
114MP0002736_abnormal_nociception_after0.77896662
115MP0000538_abnormal_urinary_bladder0.77179157
116MP0005248_abnormal_Harderian_gland0.77008589
117MP0005332_abnormal_amino_acid0.76848127
118MP0002234_abnormal_pharynx_morphology0.76249806
119MP0003121_genomic_imprinting0.76177984
120MP0008469_abnormal_protein_level0.75727812
121MP0005620_abnormal_muscle_contractility0.74034359
122MP0001186_pigmentation_phenotype0.73924735
123MP0004142_abnormal_muscle_tone0.73047144
124MP0008775_abnormal_heart_ventricle0.72555776
125MP0003122_maternal_imprinting0.72429879
126MP0001881_abnormal_mammary_gland0.71661615
127MP0000681_abnormal_thyroid_gland0.71348271
128MP0003137_abnormal_impulse_conducting0.68589057
129MP0005365_abnormal_bile_salt0.68231796
130MP0001919_abnormal_reproductive_system0.67747318
131MP0002106_abnormal_muscle_physiology0.67539726
132MP0005376_homeostasis/metabolism_phenot0.67410372
133MP0005410_abnormal_fertilization0.67356566
134MP0001544_abnormal_cardiovascular_syste0.66823025
135MP0005385_cardiovascular_system_phenoty0.66823025
136MP0008873_increased_physiological_sensi0.63839579
137MP0004019_abnormal_vitamin_homeostasis0.63333719
138MP0000647_abnormal_sebaceous_gland0.62687911
139MP0002233_abnormal_nose_morphology0.62520206
140MP0000313_abnormal_cell_death0.61875250
141MP0001697_abnormal_embryo_size0.59485082

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.54700305
2Abnormal mitochondria in muscle tissue (HP:0008316)5.23853490
3Mitochondrial inheritance (HP:0001427)4.92430471
4Progressive macrocephaly (HP:0004481)4.63041310
5Acute encephalopathy (HP:0006846)4.62775409
6Increased CSF lactate (HP:0002490)4.47034313
7Hepatic necrosis (HP:0002605)4.28779654
8Hepatocellular necrosis (HP:0001404)4.23504411
93-Methylglutaconic aciduria (HP:0003535)3.94455043
10Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89928570
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89928570
12Increased hepatocellular lipid droplets (HP:0006565)3.64728922
13Exercise intolerance (HP:0003546)3.59337266
14Cerebral edema (HP:0002181)3.39827820
15Lipid accumulation in hepatocytes (HP:0006561)3.39078028
16Increased serum lactate (HP:0002151)3.33690860
17Type I transferrin isoform profile (HP:0003642)3.26128520
18Lactic acidosis (HP:0003128)3.25439604
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.19063032
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.15554252
21Renal Fanconi syndrome (HP:0001994)3.10947993
22Macrocytic anemia (HP:0001972)3.06741141
23Microvesicular hepatic steatosis (HP:0001414)2.93350038
24Chromosomal breakage induced by crosslinking agents (HP:0003221)2.93195348
25Respiratory failure (HP:0002878)2.87833241
26Chromsome breakage (HP:0040012)2.83712513
27Increased intramyocellular lipid droplets (HP:0012240)2.80753326
28* Optic disc pallor (HP:0000543)2.79760992
29Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.72559005
30Abnormal protein N-linked glycosylation (HP:0012347)2.72559005
31Abnormal protein glycosylation (HP:0012346)2.72559005
32Abnormal glycosylation (HP:0012345)2.72559005
33Reduced antithrombin III activity (HP:0001976)2.67403034
34Abnormality of cells of the erythroid lineage (HP:0012130)2.66592357
35Renal cortical cysts (HP:0000803)2.65983365
36Abnormal hair whorl (HP:0010721)2.62888943
37Abnormal number of erythroid precursors (HP:0012131)2.60840143
38Abnormality of methionine metabolism (HP:0010901)2.54062130
39Congenital, generalized hypertrichosis (HP:0004540)2.50054094
40Generalized aminoaciduria (HP:0002909)2.49151794
41Exertional dyspnea (HP:0002875)2.47794912
42Supernumerary spleens (HP:0009799)2.44646929
43Increased muscle lipid content (HP:0009058)2.39810053
44Abnormality of aspartate family amino acid metabolism (HP:0010899)2.35580839
45Abnormality of renal resorption (HP:0011038)2.26119462
46Increased IgM level (HP:0003496)2.24344003
47Abnormality of urine glucose concentration (HP:0011016)2.22503629
48Glycosuria (HP:0003076)2.22503629
49Abnormality of serum amino acid levels (HP:0003112)2.21541770
50Colon cancer (HP:0003003)2.21063542
51Proximal tubulopathy (HP:0000114)2.18014861
52Hypothermia (HP:0002045)2.17158497
53Septo-optic dysplasia (HP:0100842)2.17091665
54Patchy hypopigmentation of hair (HP:0011365)2.15262225
55Leukodystrophy (HP:0002415)2.14578997
56True hermaphroditism (HP:0010459)2.12394236
57Pancreatic fibrosis (HP:0100732)2.12037980
58Nausea (HP:0002018)2.11546616
59Type 2 muscle fiber atrophy (HP:0003554)2.11024084
60Pancytopenia (HP:0001876)2.11003740
61Facial cleft (HP:0002006)2.08186927
62Abnormality of glycolysis (HP:0004366)2.06266232
63Increased serum pyruvate (HP:0003542)2.06266232
64Birth length less than 3rd percentile (HP:0003561)2.05050937
65Fair hair (HP:0002286)2.04253202
66Molar tooth sign on MRI (HP:0002419)2.04135134
67Abnormality of midbrain morphology (HP:0002418)2.04135134
68Oral leukoplakia (HP:0002745)2.00170696
69Lethargy (HP:0001254)1.99374185
70Respiratory difficulties (HP:0002880)1.99125086
71X-linked dominant inheritance (HP:0001423)1.96153224
72Hyperphosphaturia (HP:0003109)1.95784626
73Hyperglycinemia (HP:0002154)1.91600777
74Pallor (HP:0000980)1.87647486
75Abnormality of the labia minora (HP:0012880)1.87379344
76Median cleft lip (HP:0000161)1.87274692
77Palpitations (HP:0001962)1.86445483
78Absent septum pellucidum (HP:0001331)1.85033085
79Decreased electroretinogram (ERG) amplitude (HP:0000654)1.83765363
80Aplasia/hypoplasia of the uterus (HP:0008684)1.83763040
81Opisthotonus (HP:0002179)1.83722983
82Hypoglycemic coma (HP:0001325)1.81922634
83Hypokinesia (HP:0002375)1.81727985
84Poor head control (HP:0002421)1.81622001
85Aplastic anemia (HP:0001915)1.81414847
86Esophageal neoplasm (HP:0100751)1.81107188
87Neoplasm of head and neck (HP:0012288)1.81107188
88Megaloblastic anemia (HP:0001889)1.80720966
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.80674758
90Abnormality of alanine metabolism (HP:0010916)1.80674758
91Hyperalaninemia (HP:0003348)1.80674758
92Stenosis of the external auditory canal (HP:0000402)1.80199435
93Abnormality of the anterior horn cell (HP:0006802)1.79377000
94Degeneration of anterior horn cells (HP:0002398)1.79377000
95Absent rod-and cone-mediated responses on ERG (HP:0007688)1.77147972
96Abnormality of vitamin B metabolism (HP:0004340)1.76331268
97Methylmalonic acidemia (HP:0002912)1.75788446
98Dicarboxylic aciduria (HP:0003215)1.74787814
99Abnormality of dicarboxylic acid metabolism (HP:0010995)1.74787814
100Duplicated collecting system (HP:0000081)1.73543274
101Abnormality of the renal collecting system (HP:0004742)1.73285984
102Abnormal rod and cone electroretinograms (HP:0008323)1.72953217
103Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71524364
104Abnormality of the vitamin B12 metabolism (HP:0004341)1.71318431
105Nephrogenic diabetes insipidus (HP:0009806)1.70600393
106White forelock (HP:0002211)1.69728986
107Amniotic constriction ring (HP:0009775)1.68341251
108Abnormality of placental membranes (HP:0011409)1.68341251
109Muscle fiber atrophy (HP:0100295)1.68005175
110Emotional lability (HP:0000712)1.67989105
111Hypoplasia of the fovea (HP:0007750)1.67073767
112Aplasia/Hypoplasia of the fovea (HP:0008060)1.67073767
113Meckel diverticulum (HP:0002245)1.66154333
114Aplasia/Hypoplasia of the uvula (HP:0010293)1.65110114
115Medial flaring of the eyebrow (HP:0010747)1.64765995
116Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.64580983
117Blindness (HP:0000618)1.63921980
118Congenital primary aphakia (HP:0007707)1.62274919
119Adrenal hypoplasia (HP:0000835)1.62272825
120Dilated cardiomyopathy (HP:0001644)1.61117419
121Neoplasm of the adrenal gland (HP:0100631)1.60863149
122Renal tubular dysfunction (HP:0000124)1.59463917
123Pancreatic cysts (HP:0001737)1.59140820
124Abnormality of fatty-acid metabolism (HP:0004359)1.59023827
125Retrobulbar optic neuritis (HP:0100654)1.58878449
126Optic neuritis (HP:0100653)1.58878449
127Lipoatrophy (HP:0100578)1.58797077
128CNS demyelination (HP:0007305)1.58560396
129Abnormality of the ileum (HP:0001549)1.58165716
130Rhabdomyolysis (HP:0003201)1.57413423
131Methylmalonic aciduria (HP:0012120)1.57405625
132Alveolar cell carcinoma (HP:0006519)1.57196256
133Bone marrow hypocellularity (HP:0005528)1.56848187
134Reticulocytopenia (HP:0001896)1.56761580

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.05838749
2ZAK2.91833804
3PRPF4B2.52897472
4CASK2.49183628
5STK162.43974899
6VRK12.39959780
7NEK12.33709091
8TRIM282.21990170
9NME12.15117332
10MAP2K72.07913382
11EIF2AK32.01483462
12EIF2AK12.00415342
13TXK1.99973444
14MUSK1.98215431
15MAP3K141.97486272
16OBSCN1.95177774
17CDC71.92109123
18STK38L1.91935210
19BMPR21.87464000
20MAP4K21.87388860
21SRPK11.85681321
22YES11.81401978
23MYLK1.80277653
24NME21.77409473
25ERBB31.77143567
26TAF11.76520126
27STK241.72379458
28PIM21.67386649
29BCKDK1.62074079
30PIK3CG1.61814933
31IRAK31.61225660
32EPHA31.59146964
33INSRR1.55536809
34ADRBK21.55448776
35TLK11.55023871
36EIF2AK21.50738919
37MKNK11.43649862
38PLK41.42448115
39MKNK21.41996605
40CDK81.41743164
41PBK1.41389645
42BUB11.40034477
43GRK71.39335893
44IRAK41.28504621
45TNIK1.27759307
46AKT31.26404012
47BMPR1B1.23494771
48CDK191.22345643
49MAP3K121.16874572
50PIK3CA1.14159141
51TTK1.10681428
52WEE11.10598460
53DYRK21.08805256
54SIK31.05292614
55PINK11.02286248
56MAPK150.99446586
57GRK10.98720669
58PLK30.98129117
59IKBKB0.95715285
60TEC0.92997122
61CCNB10.91742888
62NUAK10.88324074
63NEK60.87306015
64MST40.87001988
65TAOK20.86313936
66BRAF0.84777488
67CSNK1G10.83289883
68BCR0.83269941
69EPHA20.80611650
70TSSK60.78838943
71OXSR10.78542618
72NEK90.77699956
73IRAK10.77119143
74CSNK1G30.77046194
75ILK0.73091811
76DAPK30.71758777
77WNK40.67821887
78FRK0.63990423
79DAPK10.63762467
80NLK0.63099297
81STK390.62599570
82ACVR1B0.61749622
83SGK20.61748242
84PLK20.60695360
85TRPM70.60564929
86CSNK1G20.59620757
87CSNK2A10.59574098
88RPS6KA50.58993837
89CHEK20.55891462
90CHUK0.54988355
91CDK30.53357229
92LIMK10.52204899
93PLK10.52115441
94ABL20.51166957
95RPS6KB10.49598614
96TESK10.49412976
97DYRK30.49350333
98SCYL20.48972930
99TIE10.48755827
100PRKG20.48518839
101PIM10.47573773
102ATR0.46259769
103CSNK1A1L0.45511723
104PAK40.45351190
105PASK0.45071834
106AURKB0.44014300
107MAPKAPK30.43974439
108MAP2K60.43439706
109PRKCG0.43129674
110PDK20.43116585
111TGFBR10.42932426
112MAPK130.42892401
113IKBKE0.41767292
114WNK30.41091017
115STK40.40967821
116PRKCI0.40965938
117PRKCE0.40598582
118BRSK20.39772225
119CDK70.39670079
120ERN10.39637544
121MAP3K50.38269468
122AURKA0.37766042
123STK30.37452602
124MAP3K40.37039688
125TYK20.36916394
126KDR0.36667950
127KIT0.36029927
128ERBB40.35803008
129PHKG20.35613293
130PHKG10.35613293
131CSNK1A10.35439483
132PRKCD0.35397313
133PAK10.35191854
134CSNK2A20.34626076
135LYN0.34439804
136BTK0.33872579
137CHEK10.32801100
138MAPKAPK50.32791427

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.36755409
2Parkinsons disease_Homo sapiens_hsa050123.80365995
3Proteasome_Homo sapiens_hsa030503.62773343
4Protein export_Homo sapiens_hsa030602.95254717
5Huntingtons disease_Homo sapiens_hsa050162.81592531
6RNA polymerase_Homo sapiens_hsa030202.72050763
7Alzheimers disease_Homo sapiens_hsa050102.62689113
8Ribosome_Homo sapiens_hsa030102.62037008
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.57516718
10DNA replication_Homo sapiens_hsa030302.05945057
11Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.03605966
12Mismatch repair_Homo sapiens_hsa034302.00717767
13Pyrimidine metabolism_Homo sapiens_hsa002401.98967033
14Homologous recombination_Homo sapiens_hsa034401.96272657
15Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.95710457
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93262150
17Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81137569
18Cardiac muscle contraction_Homo sapiens_hsa042601.44846432
19One carbon pool by folate_Homo sapiens_hsa006701.44447870
20Base excision repair_Homo sapiens_hsa034101.44074325
21Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32563197
22Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.32107022
23Fanconi anemia pathway_Homo sapiens_hsa034601.30865139
24Nucleotide excision repair_Homo sapiens_hsa034201.30855127
25Spliceosome_Homo sapiens_hsa030401.28998021
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.27272813
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27237027
28Allograft rejection_Homo sapiens_hsa053301.24957778
29Purine metabolism_Homo sapiens_hsa002301.23050828
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.22077102
31RNA degradation_Homo sapiens_hsa030181.21011671
32Graft-versus-host disease_Homo sapiens_hsa053321.20431176
33Basal transcription factors_Homo sapiens_hsa030221.19357209
34Peroxisome_Homo sapiens_hsa041461.17147997
35Caffeine metabolism_Homo sapiens_hsa002321.16273356
36Propanoate metabolism_Homo sapiens_hsa006401.15550332
37Legionellosis_Homo sapiens_hsa051341.14927369
38Fatty acid elongation_Homo sapiens_hsa000621.13364127
39SNARE interactions in vesicular transport_Homo sapiens_hsa041301.09029067
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08086971
41Phenylalanine metabolism_Homo sapiens_hsa003601.06910454
42Non-homologous end-joining_Homo sapiens_hsa034501.00006970
43Arachidonic acid metabolism_Homo sapiens_hsa005900.98164052
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90546148
45Metabolic pathways_Homo sapiens_hsa011000.87642415
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86960539
47Sulfur metabolism_Homo sapiens_hsa009200.86385850
48Tyrosine metabolism_Homo sapiens_hsa003500.85305661
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84589004
50Autoimmune thyroid disease_Homo sapiens_hsa053200.84222855
51Folate biosynthesis_Homo sapiens_hsa007900.83803131
52Drug metabolism - other enzymes_Homo sapiens_hsa009830.83412543
53Glutathione metabolism_Homo sapiens_hsa004800.83082549
54Steroid biosynthesis_Homo sapiens_hsa001000.80312008
55Rheumatoid arthritis_Homo sapiens_hsa053230.80299101
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80093440
57Carbon metabolism_Homo sapiens_hsa012000.79439206
58Phototransduction_Homo sapiens_hsa047440.78677585
59Other glycan degradation_Homo sapiens_hsa005110.78404515
60RNA transport_Homo sapiens_hsa030130.76404350
61beta-Alanine metabolism_Homo sapiens_hsa004100.75070966
62Sulfur relay system_Homo sapiens_hsa041220.74765195
63Type I diabetes mellitus_Homo sapiens_hsa049400.74740403
64Regulation of autophagy_Homo sapiens_hsa041400.72908856
65Pyruvate metabolism_Homo sapiens_hsa006200.72016798
66Maturity onset diabetes of the young_Homo sapiens_hsa049500.71784107
67Butanoate metabolism_Homo sapiens_hsa006500.71759643
68Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71588737
69Cysteine and methionine metabolism_Homo sapiens_hsa002700.69866141
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69405139
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69149002
72Fatty acid degradation_Homo sapiens_hsa000710.68630859
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65836525
74Starch and sucrose metabolism_Homo sapiens_hsa005000.63299167
75Chemical carcinogenesis_Homo sapiens_hsa052040.62620963
76Asthma_Homo sapiens_hsa053100.62427388
77Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62407638
78Retinol metabolism_Homo sapiens_hsa008300.60701690
79Arginine and proline metabolism_Homo sapiens_hsa003300.60255286
80Collecting duct acid secretion_Homo sapiens_hsa049660.58431590
81Fructose and mannose metabolism_Homo sapiens_hsa000510.58050900
82Vibrio cholerae infection_Homo sapiens_hsa051100.57826418
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55767717
84Phagosome_Homo sapiens_hsa041450.54728141
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54186589
86Intestinal immune network for IgA production_Homo sapiens_hsa046720.53474763
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52369656
88Selenocompound metabolism_Homo sapiens_hsa004500.52260091
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52208910
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.51307477
91Histidine metabolism_Homo sapiens_hsa003400.50642593
92Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48801366
93Galactose metabolism_Homo sapiens_hsa000520.47135462
94Epstein-Barr virus infection_Homo sapiens_hsa051690.46044466
95Cell cycle_Homo sapiens_hsa041100.44150430
96Primary bile acid biosynthesis_Homo sapiens_hsa001200.43968921
97Measles_Homo sapiens_hsa051620.43523397
98Herpes simplex infection_Homo sapiens_hsa051680.43077376
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.42887197
100Vitamin B6 metabolism_Homo sapiens_hsa007500.42319686
101p53 signaling pathway_Homo sapiens_hsa041150.42081789
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39100647
103Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38702039
104Antigen processing and presentation_Homo sapiens_hsa046120.36989123
105Linoleic acid metabolism_Homo sapiens_hsa005910.36869816
106Oocyte meiosis_Homo sapiens_hsa041140.36704506
107Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36660222
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35861336
109Primary immunodeficiency_Homo sapiens_hsa053400.34989590
110Tryptophan metabolism_Homo sapiens_hsa003800.34713551
111Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33285352
112Systemic lupus erythematosus_Homo sapiens_hsa053220.32954756
113Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31263507
114Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.31207381
115Nitrogen metabolism_Homo sapiens_hsa009100.30578941
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30342572
117N-Glycan biosynthesis_Homo sapiens_hsa005100.28858075
118Fatty acid metabolism_Homo sapiens_hsa012120.27113927
119Mineral absorption_Homo sapiens_hsa049780.21766167
120Biosynthesis of amino acids_Homo sapiens_hsa012300.21735406
121Alcoholism_Homo sapiens_hsa050340.15859398

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