TMEM127

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.29950171
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.29950171
3modulation by symbiont of host immune response (GO:0052553)4.29950171
4positive regulation by symbiont of host defense response (GO:0052509)4.29950171
5modulation by symbiont of host defense response (GO:0052031)4.29950171
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.29950171
7synaptic vesicle maturation (GO:0016188)4.13405091
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.05635500
9response to peptidoglycan (GO:0032494)4.03983502
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00170053
11macrophage activation involved in immune response (GO:0002281)4.00093116
12detection of other organism (GO:0098543)3.95861958
13antigen processing and presentation of endogenous antigen (GO:0019883)3.84072101
14regulation of short-term neuronal synaptic plasticity (GO:0048172)3.78150629
15positive regulation of gamma-delta T cell activation (GO:0046645)3.76658649
16antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.75778074
17locomotory exploration behavior (GO:0035641)3.74912199
18neutrophil activation involved in immune response (GO:0002283)3.73029571
19detection of bacterium (GO:0016045)3.70597111
20detection of molecule of bacterial origin (GO:0032490)3.57234051
21negative regulation of interleukin-12 production (GO:0032695)3.54870373
22layer formation in cerebral cortex (GO:0021819)3.53106316
23detection of external biotic stimulus (GO:0098581)3.49577154
24positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.46363302
25cellular extravasation (GO:0045123)3.45984814
26vocalization behavior (GO:0071625)3.42644919
27synaptic vesicle exocytosis (GO:0016079)3.36701875
28regulation of synaptic vesicle exocytosis (GO:2000300)3.30162393
29negative regulation of erythrocyte differentiation (GO:0045647)3.29553170
30activation of protein kinase A activity (GO:0034199)3.26375789
31sodium ion export (GO:0071436)3.24209799
32regulation of interferon-beta biosynthetic process (GO:0045357)3.23840043
33glutamate secretion (GO:0014047)3.12488957
34positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.12100209
35detection of biotic stimulus (GO:0009595)3.07272557
36cellular potassium ion homeostasis (GO:0030007)3.04259225
37regulation of synapse structural plasticity (GO:0051823)3.01326729
38proline transport (GO:0015824)2.99856418
39regulation of leukocyte degranulation (GO:0043300)2.98330281
40synaptic vesicle docking involved in exocytosis (GO:0016081)2.97749315
41regulation of mast cell degranulation (GO:0043304)2.96144268
42regulation of gamma-delta T cell activation (GO:0046643)2.94864535
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.93629909
44germinal center formation (GO:0002467)2.92243102
45lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91919133
46regulation of T-helper 2 cell differentiation (GO:0045628)2.89680775
47macrophage activation (GO:0042116)2.89354926
48positive regulation of cellular amide metabolic process (GO:0034250)2.87405809
49regulation of glutamate receptor signaling pathway (GO:1900449)2.86258061
50exploration behavior (GO:0035640)2.85268307
51response to muramyl dipeptide (GO:0032495)2.84650282
52regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84542899
53positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.83720559
54response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.83395011
55response to host immune response (GO:0052572)2.83395011
56immunoglobulin mediated immune response (GO:0016064)2.82084229
57dendrite morphogenesis (GO:0048813)2.81884589
58regulation of ARF protein signal transduction (GO:0032012)2.81550924
59regulation of synaptic vesicle transport (GO:1902803)2.79314850
60response to host (GO:0075136)2.79056876
61response to host defenses (GO:0052200)2.79056876
62response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.79056876
63neurotransmitter secretion (GO:0007269)2.78241337
64granulocyte activation (GO:0036230)2.77023887
65neutrophil activation (GO:0042119)2.74377744
66regulation of dendritic cell antigen processing and presentation (GO:0002604)2.71559185
67leukocyte aggregation (GO:0070486)2.70876761
68regulation of mast cell activation involved in immune response (GO:0033006)2.67303711
69microglial cell activation (GO:0001774)2.67135588
70negative regulation of lymphocyte mediated immunity (GO:0002707)2.64159460
71myeloid cell activation involved in immune response (GO:0002275)2.62967105
72mannose metabolic process (GO:0006013)2.60998461
73response to type I interferon (GO:0034340)2.58677005
74type I interferon signaling pathway (GO:0060337)2.58232487
75cellular response to type I interferon (GO:0071357)2.58232487
76regulation of B cell receptor signaling pathway (GO:0050855)2.57521960
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57182160
78regulation of neuronal synaptic plasticity (GO:0048168)2.57034777
79negative regulation of leukocyte mediated immunity (GO:0002704)2.56810994
80protein localization to synapse (GO:0035418)2.55444570
81response to laminar fluid shear stress (GO:0034616)2.54793055
82production of molecular mediator involved in inflammatory response (GO:0002532)2.54601082
83interferon-gamma-mediated signaling pathway (GO:0060333)2.53186719
84regulation of long-term neuronal synaptic plasticity (GO:0048169)2.51754330
85regulation of regulated secretory pathway (GO:1903305)2.51694950
86cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.51571476
87positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.51450577
88regulation of T cell tolerance induction (GO:0002664)2.50860298
89pyrimidine nucleobase catabolic process (GO:0006208)2.49652359
90positive regulation of mast cell activation (GO:0033005)2.49567073
91negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.48804087
92regulation of tolerance induction (GO:0002643)2.47535374
93positive regulation of leukocyte degranulation (GO:0043302)2.46766971
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.46720768
95dendritic spine morphogenesis (GO:0060997)2.46053662
96regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.45554359
97nucleobase catabolic process (GO:0046113)2.45206357
98regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.44713066
99regulation of gamma-delta T cell differentiation (GO:0045586)2.44678742
100positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.43327162
101antigen processing and presentation via MHC class Ib (GO:0002475)2.42469930
102protein targeting to Golgi (GO:0000042)2.42072238
103clathrin coat assembly (GO:0048268)2.41799986
104respiratory burst (GO:0045730)2.41237087
105neuron cell-cell adhesion (GO:0007158)2.41189239
106barbed-end actin filament capping (GO:0051016)2.40420580
107negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.40385074
108T-helper 1 type immune response (GO:0042088)2.40131308
109negative regulation of toll-like receptor signaling pathway (GO:0034122)2.38865380
110regulation of mast cell activation (GO:0033003)2.37480679
111cytoskeletal anchoring at plasma membrane (GO:0007016)2.37407235
112mating behavior (GO:0007617)2.37250309
113alanine transport (GO:0032328)2.36913391
114stress fiber assembly (GO:0043149)2.36823880
115negative regulation of cytokine production involved in immune response (GO:0002719)2.36558109
116negative regulation of cell killing (GO:0031342)2.36134351
117negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.36134351
118cellular response to thyroid hormone stimulus (GO:0097067)2.35914037
119cell communication by electrical coupling (GO:0010644)2.35328686
120negative regulation of interleukin-6 production (GO:0032715)2.35155252
121positive regulation of type 2 immune response (GO:0002830)2.34747494
122regulation of macrophage cytokine production (GO:0010935)2.34533376
123Golgi transport vesicle coating (GO:0048200)2.34519765
124COPI coating of Golgi vesicle (GO:0048205)2.34519765
125nerve growth factor signaling pathway (GO:0038180)2.34252437
126cerebellar Purkinje cell layer development (GO:0021680)2.33764156
127gamma-aminobutyric acid transport (GO:0015812)2.33635976
128glycosphingolipid catabolic process (GO:0046479)2.33514193
129positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.33083907
130neuron recognition (GO:0008038)2.32670371
131positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.32047143
132establishment of protein localization to Golgi (GO:0072600)2.31942584
133regulation of type 2 immune response (GO:0002828)2.31732129
134negative regulation of T cell mediated immunity (GO:0002710)2.29315840
135potassium ion import (GO:0010107)2.28949369
136pinocytosis (GO:0006907)2.27884682
137NIK/NF-kappaB signaling (GO:0038061)2.27392599
138positive regulation of receptor recycling (GO:0001921)2.26389553
139negative regulation of type 2 immune response (GO:0002829)2.25121766
140ionotropic glutamate receptor signaling pathway (GO:0035235)2.24969479
141negative regulation of innate immune response (GO:0045824)2.24968161
142regulation of antigen processing and presentation (GO:0002577)2.23887058
143myeloid dendritic cell differentiation (GO:0043011)2.22744089
144neurotransmitter-gated ion channel clustering (GO:0072578)2.22623264
145positive regulation of mast cell degranulation (GO:0043306)2.21760672
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.21760672
147negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.21309259
148protein localization to endosome (GO:0036010)2.20558425
149leukocyte migration involved in inflammatory response (GO:0002523)2.19340813
150innervation (GO:0060384)2.19113749
151positive regulation of vesicle fusion (GO:0031340)2.18901773
152neuromuscular process controlling balance (GO:0050885)2.18394824
153positive regulation of axon extension (GO:0045773)2.17792322
154positive regulation of synapse maturation (GO:0090129)2.16993415
155retrograde transport, vesicle recycling within Golgi (GO:0000301)2.14545198
156glycine transport (GO:0015816)2.13332400
157vesicle transport along microtubule (GO:0047496)2.13019060
158regulation of vesicle fusion (GO:0031338)2.12962966
159axonal fasciculation (GO:0007413)2.12528326
160cell communication involved in cardiac conduction (GO:0086065)2.11759207
161cellular sodium ion homeostasis (GO:0006883)2.11428422
162potassium ion homeostasis (GO:0055075)2.10445566
163establishment of nucleus localization (GO:0040023)2.09729198
164regulation of ARF GTPase activity (GO:0032312)2.09264757
165prepulse inhibition (GO:0060134)2.09022270
166neurotransmitter transport (GO:0006836)2.08321780
167retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.06943440
168axon extension (GO:0048675)2.06871480
169membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.06589860
170axon cargo transport (GO:0008088)2.06468773
171G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.06466827
172long-term memory (GO:0007616)2.05440070
173synaptic vesicle endocytosis (GO:0048488)2.05223081
174positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.04650294
175cerebellar Purkinje cell differentiation (GO:0021702)2.04504552
176positive regulation of membrane potential (GO:0045838)2.03235844
177membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.03005277
178regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.02012954
179regulation of excitatory postsynaptic membrane potential (GO:0060079)2.01570279
180regulation of synaptic plasticity (GO:0048167)2.00461195
181protein targeting to plasma membrane (GO:0072661)1.99681445
182response to auditory stimulus (GO:0010996)1.99365914
183signal complex assembly (GO:0007172)1.99235549
184regulation of clathrin-mediated endocytosis (GO:2000369)1.98769028
185long-term synaptic potentiation (GO:0060291)1.98492273
186cell migration in hindbrain (GO:0021535)1.97993857
187macroautophagy (GO:0016236)1.97603812
188organelle transport along microtubule (GO:0072384)1.97066486
189dopamine receptor signaling pathway (GO:0007212)1.97027992
190synapse assembly (GO:0007416)1.97003388
191cellular response to glucagon stimulus (GO:0071377)1.95970939
192glutamate receptor signaling pathway (GO:0007215)1.95919783
193regulation of dendritic spine morphogenesis (GO:0061001)1.95876889
194suckling behavior (GO:0001967)1.95155574
195positive regulation of potassium ion transmembrane transporter activity (GO:1901018)1.94319648
196adenosine receptor signaling pathway (GO:0001973)1.94223898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human3.60625525
2EZH2_22144423_ChIP-Seq_EOC_Human2.79523707
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.75996315
4IRF8_21731497_ChIP-ChIP_J774_Mouse2.62755782
5SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62257019
6NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.47290233
7IRF8_27001747_Chip-Seq_BMDM_Mouse2.45049720
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43225432
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.38502160
10TP63_17297297_ChIP-ChIP_HaCaT_Human2.24497222
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.19706397
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.16089460
13VDR_21846776_ChIP-Seq_THP-1_Human2.14404620
14VDR_24763502_ChIP-Seq_THP-1_Human2.14074670
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.13209204
16DROSHA_22980978_ChIP-Seq_HELA_Human2.11935060
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.08304343
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.99391119
19MTF2_20144788_ChIP-Seq_MESCs_Mouse1.97252382
20ELK3_25401928_ChIP-Seq_HUVEC_Human1.93959815
21IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.91595872
22SPI1_23127762_ChIP-Seq_K562_Human1.89219635
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89035465
24EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89035465
25SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87176730
26* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86708893
27TCF7_22412390_ChIP-Seq_EML_Mouse1.86569973
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.84612244
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.83913813
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.81517366
31BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77008582
32JARID2_20075857_ChIP-Seq_MESCs_Mouse1.73978063
33RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.70736947
34* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69342395
35KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.68865363
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.67695744
37STAT6_21828071_ChIP-Seq_BEAS2B_Human1.67503377
38RUNX1_22412390_ChIP-Seq_EML_Mouse1.67395329
39SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.67129210
40SUZ12_27294783_Chip-Seq_ESCs_Mouse1.65771076
41TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65136934
42GBX2_23144817_ChIP-Seq_PC3_Human1.65013600
43E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.64973508
44MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59908617
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.59883071
46AR_21572438_ChIP-Seq_LNCaP_Human1.58396722
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.56519564
48IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56512132
49* MAF_26560356_Chip-Seq_TH1_Human1.54106368
50REST_21632747_ChIP-Seq_MESCs_Mouse1.53070741
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.52876299
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.51383416
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50797978
54RACK7_27058665_Chip-Seq_MCF-7_Human1.50481054
55SMAD_19615063_ChIP-ChIP_OVARY_Human1.49734955
56STAT4_19710469_ChIP-ChIP_TH1__Mouse1.47665719
57MYC_22102868_ChIP-Seq_BL_Human1.45692297
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.45474984
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.45454487
60SCL_19346495_ChIP-Seq_HPC-7_Human1.45081631
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.42408783
62FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.42065059
63ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40660374
64EZH2_27304074_Chip-Seq_ESCs_Mouse1.39830439
65CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38698915
66KDM2B_26808549_Chip-Seq_K562_Human1.36474841
67SPI1_23547873_ChIP-Seq_NB4_Human1.35865345
68GATA1_19941826_ChIP-Seq_K562_Human1.33000403
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.32183050
70GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31069661
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30623109
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.30549453
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29216672
74UTX_26944678_Chip-Seq_JUKART_Human1.29140797
75NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29016792
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.28810657
77WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28431953
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.27489439
79PPARA_22158963_ChIP-Seq_LIVER_Mouse1.26631908
80REST_18959480_ChIP-ChIP_MESCs_Mouse1.26284497
81RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23744186
82IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22894753
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22483922
84AHR_22903824_ChIP-Seq_MCF-7_Human1.22436920
85* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.21709982
86STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.21384739
87KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.20928180
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20792850
89WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20716470
90ESR1_20079471_ChIP-ChIP_T-47D_Human1.19010785
91CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19001455
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16435527
93ESR2_21235772_ChIP-Seq_MCF-7_Human1.14774426
94FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14075365
95LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13904758
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.13858888
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.13509724
98CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11514490
99SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10998675
100EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.10983317
101RXR_22108803_ChIP-Seq_LS180_Human1.10740603
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10408567
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09569634
104PU_27001747_Chip-Seq_BMDM_Mouse1.09328637
105ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.09252188
106NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08934845
107PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08484512
108FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.08194759
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.07928816
110PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06532488
111SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05919351
112GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.05066406
113PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.04763585
114MAF_26560356_Chip-Seq_TH2_Human1.04263869
115GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03789839
116MYB_26560356_Chip-Seq_TH2_Human1.03686722
117P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03652481
118THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.02456703
119SMAD4_21799915_ChIP-Seq_A2780_Human1.02218439
120SOX2_21211035_ChIP-Seq_LN229_Gbm1.02112469
121SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01044848
122CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01038674
123* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00521620
124LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99813262
125MYB_26560356_Chip-Seq_TH1_Human0.98919338
126KDM2B_26808549_Chip-Seq_DND41_Human0.98731640
127NRF2_20460467_ChIP-Seq_MEFs_Mouse0.98669838
128NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.98669838
129LXR_22292898_ChIP-Seq_THP-1_Human0.98471000
130AR_19668381_ChIP-Seq_PC3_Human0.98368452
131GATA2_19941826_ChIP-Seq_K562_Human0.98151942
132TBX20_22328084_ChIP-Seq_HEART_Mouse0.97981080
133TBX20_22080862_ChIP-Seq_HEART_Mouse0.97981080
134NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97958706
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97037327
136STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96769097
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96646327
138TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95995055
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.95891254
140AR_25329375_ChIP-Seq_VCAP_Human0.95823888
141SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95168098
142GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95026909
143ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94593923
144NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.94282994
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.94281320
146RUNX_20019798_ChIP-Seq_JUKART_Human0.92743566
147CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92668149
148GATA2_21666600_ChIP-Seq_HMVEC_Human0.91629828
149* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91243860
150CLOCK_20551151_ChIP-Seq_293T_Human0.90942500
151* FOXA2_19822575_ChIP-Seq_HepG2_Human0.90799005
152KDM2B_26808549_Chip-Seq_JURKAT_Human0.90434671
153PIAS1_25552417_ChIP-Seq_VCAP_Human0.90190963
154CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89867177
155RING1B_27294783_Chip-Seq_ESCs_Mouse0.88239708
156DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.87470109
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.87153934
158SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87134840
159ZNF274_21170338_ChIP-Seq_K562_Hela0.86240497
160BCAT_22108803_ChIP-Seq_LS180_Human0.84828666
161EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83267631
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82260718
163* FOXO3_23340844_ChIP-Seq_DLD1_Human0.81833845
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81822448
165STAT3_23295773_ChIP-Seq_U87_Human0.80867539
166VDR_24787735_ChIP-Seq_THP-1_Human0.80796839
167TP53_16413492_ChIP-PET_HCT116_Human0.80594182
168Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.80154912
169CTNNB1_20460455_ChIP-Seq_HCT116_Human0.79961402
170LXR_22158963_ChIP-Seq_LIVER_Mouse0.79612392
171TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78951958
172TP53_18474530_ChIP-ChIP_U2OS_Human0.78745616
173RING1B_27294783_Chip-Seq_NPCs_Mouse0.78135873
174KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77389539
175OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77161055
176YAP1_20516196_ChIP-Seq_MESCs_Mouse0.76824923

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.65692376
2MP0003436_decreased_susceptibility_to3.50836529
3MP0003724_increased_susceptibility_to3.45214686
4MP0009780_abnormal_chondrocyte_physiolo3.44591624
5MP0004270_analgesia2.93705752
6MP0003635_abnormal_synaptic_transmissio2.85264916
7MP0001835_abnormal_antigen_presentation2.60591321
8MP0002419_abnormal_innate_immunity2.51248448
9MP0009840_abnormal_foam_cell2.49385813
10MP0006082_CNS_inflammation2.45561095
11MP0002909_abnormal_adrenal_gland2.38620363
12MP0003329_amyloid_beta_deposits2.27041896
13MP0002063_abnormal_learning/memory/cond2.24177226
14MP0005025_abnormal_response_to2.23290482
15MP0009785_altered_susceptibility_to2.21834861
16MP0000685_abnormal_immune_system2.19362185
17MP0000013_abnormal_adipose_tissue2.16953149
18MP0001790_abnormal_immune_system2.16786046
19MP0005387_immune_system_phenotype2.16786046
20MP0001533_abnormal_skeleton_physiology2.12218903
21MP0004858_abnormal_nervous_system2.11710709
22MP0005000_abnormal_immune_tolerance2.11196901
23MP0002148_abnormal_hypersensitivity_rea2.05834350
24MP0005451_abnormal_body_composition2.03909883
25MP0003880_abnormal_central_pattern2.00878688
26MP0002064_seizures1.95722206
27MP0009745_abnormal_behavioral_response1.93395497
28MP0005671_abnormal_response_to1.85087349
29MP0001800_abnormal_humoral_immune1.84683636
30MP0003828_pulmonary_edema1.84143935
31MP0002452_abnormal_antigen_presenting1.82431489
32MP0008961_abnormal_basal_metabolism1.81677297
33MP0003300_gastrointestinal_ulcer1.79632309
34MP0002723_abnormal_immune_serum1.78324191
35MP0005423_abnormal_somatic_nervous1.77837541
36MP0008260_abnormal_autophagy1.77673233
37MP0009046_muscle_twitch1.77269032
38MP0005464_abnormal_platelet_physiology1.76046129
39MP0000604_amyloidosis1.75444629
40MP0003303_peritoneal_inflammation1.75286153
41MP0000569_abnormal_digit_pigmentation1.74732179
42MP0003045_fibrosis1.72182351
43MP0002998_abnormal_bone_remodeling1.71801832
44MP0010155_abnormal_intestine_physiology1.71188251
45MP0003172_abnormal_lysosome_physiology1.69309158
46MP0002734_abnormal_mechanical_nocicepti1.68643260
47MP0002420_abnormal_adaptive_immunity1.66781094
48MP0001819_abnormal_immune_cell1.66156299
49MP0002572_abnormal_emotion/affect_behav1.64638637
50MP0001968_abnormal_touch/_nociception1.62852869
51MP0003183_abnormal_peptide_metabolism1.62037143
52MP0004130_abnormal_muscle_cell1.61961565
53MP0001348_abnormal_lacrimal_gland1.57719226
54MP0010234_abnormal_vibrissa_follicle1.57334368
55MP0003566_abnormal_cell_adhesion1.56518242
56MP0009278_abnormal_bone_marrow1.54281806
57MP0000858_altered_metastatic_potential1.46974101
58MP0002837_dystrophic_cardiac_calcinosis1.46458847
59MP0001845_abnormal_inflammatory_respons1.46382468
60MP0008569_lethality_at_weaning1.45242784
61MP0002405_respiratory_system_inflammati1.40553023
62MP0002733_abnormal_thermal_nociception1.39973150
63MP0004811_abnormal_neuron_physiology1.39265706
64MP0003690_abnormal_glial_cell1.39245804
65MP0000343_altered_response_to1.38507949
66MP0002735_abnormal_chemical_nociception1.38163871
67MP0003075_altered_response_to1.33747285
68MP0004043_abnormal_pH_regulation1.31723405
69MP0005058_abnormal_lysosome_morphology1.31277757
70MP0005409_darkened_coat_color1.30100960
71MP0003279_aneurysm1.28497662
72MP0003633_abnormal_nervous_system1.28090536
73MP0003453_abnormal_keratinocyte_physiol1.26040848
74MP0005164_abnormal_response_to1.25867407
75MP0001970_abnormal_pain_threshold1.25809585
76MP0003879_abnormal_hair_cell1.25318324
77MP0001501_abnormal_sleep_pattern1.24922871
78MP0008469_abnormal_protein_level1.24418310
79MP0001486_abnormal_startle_reflex1.24216541
80MP0009764_decreased_sensitivity_to1.23301156
81MP0002272_abnormal_nervous_system1.23264818
82MP0004883_abnormal_blood_vessel1.21020936
83MP0000778_abnormal_nervous_system1.20897970
84MP0009333_abnormal_splenocyte_physiolog1.18312376
85MP0002090_abnormal_vision1.17566970
86MP0003448_altered_tumor_morphology1.17456866
87MP0000716_abnormal_immune_system1.16496892
88MP0002184_abnormal_innervation1.15253238
89MP0004510_myositis1.14095463
90MP0010386_abnormal_urinary_bladder1.13267460
91MP0001851_eye_inflammation1.12904739
92MP0003866_abnormal_defecation1.12226065
93MP0003763_abnormal_thymus_physiology1.10172353
94MP0001440_abnormal_grooming_behavior1.09401453
95MP0004885_abnormal_endolymph1.09051507
96MP0000465_gastrointestinal_hemorrhage1.07956830
97MP0005390_skeleton_phenotype1.07686142
98MP0002557_abnormal_social/conspecific_i1.06332029
99MP0002736_abnormal_nociception_after1.05564774
100MP0001299_abnormal_eye_distance/1.04488692
101MP0002067_abnormal_sensory_capabilities1.04230752
102MP0008004_abnormal_stomach_pH1.04077502
103MP0005623_abnormal_meninges_morphology1.03912642
104MP0005535_abnormal_body_temperature1.03843130
105MP0005023_abnormal_wound_healing1.03739978
106MP0001849_ear_inflammation1.02418931
107MP0000003_abnormal_adipose_tissue1.02389158
108MP0000955_abnormal_spinal_cord1.00751183
109MP0002398_abnormal_bone_marrow1.00327473
110MP0005076_abnormal_cell_differentiation0.99928279
111MP0005397_hematopoietic_system_phenotyp0.99548894
112MP0001545_abnormal_hematopoietic_system0.99548894
113MP0001765_abnormal_ion_homeostasis0.96087964
114MP0000920_abnormal_myelination0.95378313
115MP0001502_abnormal_circadian_rhythm0.95223345
116MP0001853_heart_inflammation0.95222135
117MP0003252_abnormal_bile_duct0.94628703
118MP0003634_abnormal_glial_cell0.94517151
119MP0003631_nervous_system_phenotype0.93822932
120MP0001984_abnormal_olfaction0.92829374
121MP0000249_abnormal_blood_vessel0.91983718
122MP0000767_abnormal_smooth_muscle0.91758788
123MP0002822_catalepsy0.91593157
124MP0008874_decreased_physiological_sensi0.90996652
125MP0005310_abnormal_salivary_gland0.88908134
126MP0002254_reproductive_system_inflammat0.87500607
127MP0002429_abnormal_blood_cell0.87264673
128MP0004924_abnormal_behavior0.86811329
129MP0005386_behavior/neurological_phenoty0.86811329
130MP0002066_abnormal_motor_capabilities/c0.86754333
131MP0002132_abnormal_respiratory_system0.86266435
132MP0005167_abnormal_blood-brain_barrier0.86131536
133MP0002933_joint_inflammation0.85111870
134MP0003091_abnormal_cell_migration0.84486733
135MP0002896_abnormal_bone_mineralization0.84352295
136MP0005165_increased_susceptibility_to0.84061332
137MP0002882_abnormal_neuron_morphology0.83474474
138MP0005365_abnormal_bile_salt0.83462288
139MP0003283_abnormal_digestive_organ0.83072879
140MP0004381_abnormal_hair_follicle0.82579912
141MP0008438_abnormal_cutaneous_collagen0.82330905
142MP0003795_abnormal_bone_structure0.82189433
143MP0005360_urolithiasis0.81110330
144MP0002722_abnormal_immune_system0.80513015
145MP0000689_abnormal_spleen_morphology0.80028980
146MP0010329_abnormal_lipoprotein_level0.77628416
147MP0001177_atelectasis0.77368770
148MP0002139_abnormal_hepatobiliary_system0.77138005
149MP0002876_abnormal_thyroid_physiology0.76918716
150MP0000751_myopathy0.76756520
151MP0002078_abnormal_glucose_homeostasis0.76112361
152MP0006054_spinal_hemorrhage0.75543712
153MP0003191_abnormal_cellular_cholesterol0.75238599
154MP0004264_abnormal_extraembryonic_tissu0.75219698
155MP0001663_abnormal_digestive_system0.74924091
156MP0002796_impaired_skin_barrier0.73541104
157MP0002069_abnormal_eating/drinking_beha0.73152956
158MP0004947_skin_inflammation0.72812851
159MP0001958_emphysema0.71937757
160MP0003705_abnormal_hypodermis_morpholog0.71007350
161MP0004185_abnormal_adipocyte_glucose0.70824612
162MP0009763_increased_sensitivity_to0.69221277
163MP0001756_abnormal_urination0.68293869
164MP0005448_abnormal_energy_balance0.67530157
165MP0005275_abnormal_skin_tensile0.67321588
166MP0001542_abnormal_bone_strength0.66414573
167MP0005166_decreased_susceptibility_to0.65756473
168MP0003632_abnormal_nervous_system0.65412777
169MP0002168_other_aberrant_phenotype0.64595592
170MP0002877_abnormal_melanocyte_morpholog0.64274602
171MP0005375_adipose_tissue_phenotype0.64148194
172MP0002229_neurodegeneration0.63874037
173MP0004085_abnormal_heartbeat0.62560476

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)4.94165886
2Abnormality of macrophages (HP:0004311)4.33426866
3Abnormality of liposaccharide metabolism (HP:0010968)4.04479109
4Abnormality of glycosphingolipid metabolism (HP:0004343)4.04479109
5Abnormality of glycolipid metabolism (HP:0010969)4.04479109
6Recurrent abscess formation (HP:0002722)3.94978386
7Recurrent bacterial skin infections (HP:0005406)3.92068556
8Myositis (HP:0100614)3.76377032
9Orchitis (HP:0100796)3.73842268
10Supranuclear gaze palsy (HP:0000605)3.58519594
11Recurrent gram-negative bacterial infections (HP:0005420)3.46470562
12Visual hallucinations (HP:0002367)3.28900518
13Focal seizures (HP:0007359)3.23199432
14Optic neuritis (HP:0100653)3.20136916
15Retrobulbar optic neuritis (HP:0100654)3.20136916
16Papilledema (HP:0001085)3.19786400
17Myokymia (HP:0002411)3.11521402
18Systemic lupus erythematosus (HP:0002725)3.11074188
19Focal motor seizures (HP:0011153)3.05704381
20Amyloidosis (HP:0011034)2.99200759
21Cerebral inclusion bodies (HP:0100314)2.94568405
22Neurofibrillary tangles (HP:0002185)2.87702496
23Spontaneous hematomas (HP:0007420)2.84458694
24Action tremor (HP:0002345)2.79520345
25Gingivitis (HP:0000230)2.78731276
26Increased neuronal autofluorescent lipopigment (HP:0002074)2.74784565
27Elevated erythrocyte sedimentation rate (HP:0003565)2.74236867
28Absence seizures (HP:0002121)2.73822519
29Atonic seizures (HP:0010819)2.71419300
30Loss of speech (HP:0002371)2.69050538
31Vacuolated lymphocytes (HP:0001922)2.67517895
32Mediastinal lymphadenopathy (HP:0100721)2.66932604
33Epileptic encephalopathy (HP:0200134)2.66473133
34Stomatitis (HP:0010280)2.62523346
35Increased IgE level (HP:0003212)2.59148289
36Agitation (HP:0000713)2.58656687
37Recurrent skin infections (HP:0001581)2.58324164
38Dysostosis multiplex (HP:0000943)2.52675729
39Cerebral aneurysm (HP:0004944)2.49357846
40Recurrent fungal infections (HP:0002841)2.49179093
41Peritonitis (HP:0002586)2.46094712
42Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.45949872
43Gastrointestinal infarctions (HP:0005244)2.45067369
44Ankle clonus (HP:0011448)2.42485673
45Macroorchidism (HP:0000053)2.40583926
46Progressive cerebellar ataxia (HP:0002073)2.36007530
47Malnutrition (HP:0004395)2.35437632
48Mucopolysacchariduria (HP:0008155)2.34946756
49Urinary glycosaminoglycan excretion (HP:0003541)2.34946756
50Cellulitis (HP:0100658)2.34302925
51Chronic obstructive pulmonary disease (HP:0006510)2.33185796
52Obstructive lung disease (HP:0006536)2.33185796
53Purpura (HP:0000979)2.32918764
54Mutism (HP:0002300)2.30313013
55Keratoconjunctivitis sicca (HP:0001097)2.29174499
56Abnormal social behavior (HP:0012433)2.27986624
57Impaired social interactions (HP:0000735)2.27986624
58Hypercortisolism (HP:0001578)2.27138278
59Asymmetric septal hypertrophy (HP:0001670)2.26856830
60Vasculitis (HP:0002633)2.26334149
61Pulmonary infiltrates (HP:0002113)2.25893250
62Dialeptic seizures (HP:0011146)2.23056992
63Gingival bleeding (HP:0000225)2.21176788
64Generalized tonic-clonic seizures (HP:0002069)2.20926659
65Urticaria (HP:0001025)2.20857316
66Abnormal eating behavior (HP:0100738)2.19995398
67Myocardial infarction (HP:0001658)2.19644176
68Hemiplegia (HP:0002301)2.19632233
69Hand muscle atrophy (HP:0009130)2.19271418
70Abnormality of polysaccharide metabolism (HP:0011012)2.19265382
71Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19265382
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19265382
73Meningitis (HP:0001287)2.19081417
74Upper limb amyotrophy (HP:0009129)2.18897474
75Distal upper limb amyotrophy (HP:0007149)2.18897474
76Hemoptysis (HP:0002105)2.17238606
77Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.16202084
78Vertebral compression fractures (HP:0002953)2.14559891
79Truncal ataxia (HP:0002078)2.13888404
80Depression (HP:0000716)2.12828482
81Arterial tortuosity (HP:0005116)2.12314394
82Prolonged bleeding time (HP:0003010)2.09828963
83Chronic mucocutaneous candidiasis (HP:0002728)2.09571957
84Recurrent cutaneous fungal infections (HP:0011370)2.09571957
85Hemorrhage of the eye (HP:0011885)2.09533376
86Epistaxis (HP:0000421)2.08531010
87Torticollis (HP:0000473)2.07102190
88Genetic anticipation (HP:0003743)2.05922097
89Interstitial pulmonary disease (HP:0006530)2.04422853
90Keratoconjunctivitis (HP:0001096)2.02923806
91Poor eye contact (HP:0000817)2.02429873
92Urinary bladder sphincter dysfunction (HP:0002839)2.01976888
93Pustule (HP:0200039)2.01194716
94Vascular tortuosity (HP:0004948)2.01063341
95Postural instability (HP:0002172)2.00658382
96Increased cerebral lipofuscin (HP:0011813)1.99725888
97Episodic fever (HP:0001954)1.99545096
98Glomerulonephritis (HP:0000099)1.96654645
99Axonal loss (HP:0003447)1.96154685
100Thin bony cortex (HP:0002753)1.95838971
101Striae distensae (HP:0001065)1.95635049
102Arterial thrombosis (HP:0004420)1.95633464
103Intention tremor (HP:0002080)1.95596193
104Urinary urgency (HP:0000012)1.94674289
105Chest pain (HP:0100749)1.93663094
106Febrile seizures (HP:0002373)1.92313558
107Lower limb amyotrophy (HP:0007210)1.91246968
108Abnormality of complement system (HP:0005339)1.90198660
109Distal lower limb muscle weakness (HP:0009053)1.89951674
110Insidious onset (HP:0003587)1.88759087
111Termporal pattern (HP:0011008)1.88759087
112Protrusio acetabuli (HP:0003179)1.87603919
113Dysmetric saccades (HP:0000641)1.87433982
114Spondylolisthesis (HP:0003302)1.87092702
115Polyphagia (HP:0002591)1.86305890
116Increased serum ferritin (HP:0003281)1.85880258
117Pulmonary embolism (HP:0002204)1.85484625
118Mitral stenosis (HP:0001718)1.85071630
119Segmental peripheral demyelination/remyelination (HP:0003481)1.84805989
120Polycythemia (HP:0001901)1.84670090
121Neuronal loss in central nervous system (HP:0002529)1.84639277
122Hematochezia (HP:0002573)1.84511428
123Pheochromocytoma (HP:0002666)1.84207254
124Long toe (HP:0010511)1.82468127
125Petechiae (HP:0000967)1.81035923
126Obstructive sleep apnea (HP:0002870)1.80246704
127Apathy (HP:0000741)1.78908425
128Lower limb muscle weakness (HP:0007340)1.77162819
129Abnormal delayed hypersensitivity skin test (HP:0002963)1.77099776
130Osteomyelitis (HP:0002754)1.76970703
131Aortic aneurysm (HP:0004942)1.76804986
132Premature loss of primary teeth (HP:0006323)1.76415485
133Pathologic fracture (HP:0002756)1.75894481
134Stereotypic behavior (HP:0000733)1.75736539
135Excessive salivation (HP:0003781)1.75408493
136Drooling (HP:0002307)1.75408493
137Impaired vibration sensation in the lower limbs (HP:0002166)1.75260293
138EEG with generalized epileptiform discharges (HP:0011198)1.74711321
139Amyotrophic lateral sclerosis (HP:0007354)1.74015874
140Ankyloglossia (HP:0010296)1.73861379
141Epileptiform EEG discharges (HP:0011182)1.73030382
142Emphysema (HP:0002097)1.72721202
143Acne (HP:0001061)1.72612445
144Abnormality of the peritoneum (HP:0002585)1.72164944
145Rapidly progressive (HP:0003678)1.71954532
146Encephalitis (HP:0002383)1.71937886
147Anxiety (HP:0000739)1.71044179
148Hypsarrhythmia (HP:0002521)1.70527934
149Bone pain (HP:0002653)1.70305653
150Abnormality of the nasal mucosa (HP:0000433)1.69839974
151Spastic gait (HP:0002064)1.69423499
152Broad-based gait (HP:0002136)1.69403470
153Retinal atrophy (HP:0001105)1.69364913
154Complement deficiency (HP:0004431)1.69274181
155Buphthalmos (HP:0000557)1.69219076
156Recurrent viral infections (HP:0004429)1.69083364
157Adrenal overactivity (HP:0002717)1.68774005
158Abnormality of the endocardium (HP:0004306)1.68624371
159Aneurysm (HP:0002617)1.68361818
160Polygenic inheritance (HP:0010982)1.68085208
161Megalencephaly (HP:0001355)1.68009252
162Abnormality of oral frenula (HP:0000190)1.67524007
163Focal dystonia (HP:0004373)1.66849634
164Hyperventilation (HP:0002883)1.66090597
165Restrictive lung disease (HP:0002091)1.65495179
166Disinhibition (HP:0000734)1.65494531
167Akinesia (HP:0002304)1.64795027
168Dysdiadochokinesis (HP:0002075)1.64465595
169Inappropriate behavior (HP:0000719)1.63597837
170Open mouth (HP:0000194)1.63051144
171Dilatation of the ascending aorta (HP:0005111)1.62292320
172Diplopia (HP:0000651)1.61897493
173Abnormality of binocular vision (HP:0011514)1.61897493
174Subacute progressive viral hepatitis (HP:0006572)1.60861049
175Abnormality of the lower motor neuron (HP:0002366)1.60626952
176Abnormality of the corticospinal tract (HP:0002492)1.60624113
177Craniofacial dystonia (HP:0012179)1.60048069
178Scanning speech (HP:0002168)1.59424208
179Exotropia (HP:0000577)1.58627739
180Hyporeflexia of lower limbs (HP:0002600)1.58290270
181Increased circulating renin level (HP:0000848)1.57288065
182Dysmetria (HP:0001310)1.57214737
183Progressive inability to walk (HP:0002505)1.57047300

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK13.05710876
2PRPF4B2.91826640
3MAP3K92.85043335
4NTRK32.37711286
5TYK22.34872594
6BLK2.33877455
7MAP2K32.26308200
8TRIB32.16226857
9MAP3K32.11083322
10MAP4K12.09700931
11IRAK42.09480469
12MINK11.97750993
13NTRK11.95502744
14CSK1.94264406
15PRKD31.80695505
16ZAP701.80426315
17IRAK31.78612152
18KSR21.76580171
19PAK61.75623421
20MAP3K41.73706019
21MAP3K141.70245645
22CAMKK11.70222329
23RIPK11.65350980
24MAP3K21.63850323
25DAPK21.63423045
26PRKCH1.56877201
27ERN11.49326729
28MAP3K111.48574476
29TBK11.44570969
30RET1.41313257
31PAK31.41273041
32MAP2K41.40972994
33NTRK21.38235859
34SIK21.35725659
35JAK31.31095921
36PDGFRA1.29302996
37EPHA41.29040820
38CAMKK21.25743385
39MAP3K121.25551643
40PRKD21.18844169
41FGR1.18480427
42FGFR41.18188688
43FRK1.16589135
44SMG11.16516810
45TAOK21.16043408
46PHKG11.13176769
47PHKG21.13176769
48JAK11.11256499
49PKN21.10919772
50CDK51.08638519
51HCK1.07858802
52PTK61.07727755
53SGK31.07610605
54KSR11.07466890
55FGFR31.07390182
56SIK31.05435010
57RIPK41.04534337
58IKBKE1.04176232
59MAP3K71.03622400
60TNK21.02430109
61SCYL21.00550417
62MATK0.99284224
63CAMK1G0.98538229
64TYRO30.97704328
65LMTK20.96270339
66FGFR20.93340485
67BTK0.92997483
68CSF1R0.92233515
69DMPK0.92047076
70EPHB10.91195490
71TAOK10.91065158
72STK380.90300278
73SYK0.89969301
74PTK20.88603562
75CDK120.86102128
76MAP3K130.85862839
77SGK2230.84700719
78SGK4940.84700719
79MAP3K60.84537696
80MAP2K70.83649863
81GRK50.83527683
82RPS6KA20.82421555
83KIT0.81749439
84MAPK70.80331133
85TTN0.79934574
86SIK10.79047076
87MAPK120.78974171
88MARK20.78673637
89FER0.77579623
90IRAK20.77400990
91GRK70.77258141
92IRAK10.76756216
93WNK10.74888877
94FYN0.74813702
95TGFBR20.74770303
96FES0.74731856
97IKBKB0.73759007
98STK110.71882747
99EPHA30.71820770
100PAK40.71398067
101WNK40.70749731
102SGK20.69904394
103MAP3K10.69611520
104PDGFRB0.69420153
105LYN0.69159770
106PDK10.67083547
107LCK0.66443622
108PRKG20.66135027
109CDC42BPA0.65921282
110JAK20.65902646
111LATS20.64640062
112MAP2K10.64560067
113PRKCZ0.64158697
114PTK2B0.64041126
115BMPR20.63529773
116RPS6KL10.63512793
117RPS6KC10.63512793
118TESK10.60438370
119TESK20.60181742
120SGK10.60035830
121NEK90.59471758
122EPHA20.59184378
123PRKCG0.58063731
124ARAF0.57541296
125PDPK10.57510514
126MOS0.56332935
127PIK3CG0.53321946
128PRKCE0.52802277
129PLK20.52375732
130DDR20.51553097
131MYLK0.51314370
132YES10.51291056
133TRPM70.50572780
134PRKD10.50520047
135TXK0.50445576
136ALK0.50379351
137RPS6KA60.50127194
138LRRK20.50019032
139INSRR0.49590534
140MST1R0.49145630
141CHUK0.48574952
142MARK30.48456484
143HIPK20.47455843
144BMX0.47159583
145ITK0.46236329
146ERBB30.45998944
147CAMK2A0.45872973
148UHMK10.45516429
149STK100.43929184
150CAMK1D0.43805900
151MAPKAPK20.43752522
152PRKCQ0.43395779
153CDK140.43058069
154SRC0.42904750
155ROCK10.42288057
156ICK0.41900986
157GRK60.40632411

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.37089573
2Other glycan degradation_Homo sapiens_hsa005112.36062044
3Leishmaniasis_Homo sapiens_hsa051402.22733443
4Synaptic vesicle cycle_Homo sapiens_hsa047212.05932957
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.87146140
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.81542842
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77561800
8B cell receptor signaling pathway_Homo sapiens_hsa046621.64093248
9GABAergic synapse_Homo sapiens_hsa047271.63690987
10Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.61557509
11Circadian entrainment_Homo sapiens_hsa047131.56588416
12Long-term potentiation_Homo sapiens_hsa047201.51306131
13Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50850969
14Malaria_Homo sapiens_hsa051441.49961415
15Nicotine addiction_Homo sapiens_hsa050331.47258665
16Acute myeloid leukemia_Homo sapiens_hsa052211.45549528
17Toxoplasmosis_Homo sapiens_hsa051451.44660492
18Salivary secretion_Homo sapiens_hsa049701.44115504
19Olfactory transduction_Homo sapiens_hsa047401.43919938
20Gastric acid secretion_Homo sapiens_hsa049711.43641593
21Insulin secretion_Homo sapiens_hsa049111.43637514
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43221673
23Morphine addiction_Homo sapiens_hsa050321.42841643
24Renin secretion_Homo sapiens_hsa049241.42080851
25Allograft rejection_Homo sapiens_hsa053301.39966750
26Graft-versus-host disease_Homo sapiens_hsa053321.39738251
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37886907
28TNF signaling pathway_Homo sapiens_hsa046681.35793083
29Glutamatergic synapse_Homo sapiens_hsa047241.33679367
30Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33127550
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32380195
32Dopaminergic synapse_Homo sapiens_hsa047281.32209498
33Type II diabetes mellitus_Homo sapiens_hsa049301.30992224
34Cholinergic synapse_Homo sapiens_hsa047251.30017063
35Pertussis_Homo sapiens_hsa051331.29512335
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.28428657
37Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25749102
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.25727862
39Autoimmune thyroid disease_Homo sapiens_hsa053201.24356525
40Phagosome_Homo sapiens_hsa041451.23419462
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.22149987
42Influenza A_Homo sapiens_hsa051641.21715580
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21123886
44Amphetamine addiction_Homo sapiens_hsa050311.20793214
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.18740332
46Hepatitis C_Homo sapiens_hsa051601.14707538
47Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13960783
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.12069214
49Oxytocin signaling pathway_Homo sapiens_hsa049211.10442319
50Cocaine addiction_Homo sapiens_hsa050301.10417400
51Carbohydrate digestion and absorption_Homo sapiens_hsa049731.08091938
52Estrogen signaling pathway_Homo sapiens_hsa049151.06941219
53Nitrogen metabolism_Homo sapiens_hsa009101.06939318
54Measles_Homo sapiens_hsa051621.06337475
55Glioma_Homo sapiens_hsa052141.05277185
56Viral myocarditis_Homo sapiens_hsa054161.04660403
57Hematopoietic cell lineage_Homo sapiens_hsa046401.03135809
58Chronic myeloid leukemia_Homo sapiens_hsa052201.02786577
59Rheumatoid arthritis_Homo sapiens_hsa053231.02696973
60GnRH signaling pathway_Homo sapiens_hsa049121.01945673
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00917761
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00206416
63Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.98253592
64Antigen processing and presentation_Homo sapiens_hsa046120.96728283
65Salmonella infection_Homo sapiens_hsa051320.96370732
66Intestinal immune network for IgA production_Homo sapiens_hsa046720.94633671
67Legionellosis_Homo sapiens_hsa051340.93317787
68Jak-STAT signaling pathway_Homo sapiens_hsa046300.92294906
69RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92156382
70Axon guidance_Homo sapiens_hsa043600.91397152
71Hepatitis B_Homo sapiens_hsa051610.91242257
72Complement and coagulation cascades_Homo sapiens_hsa046100.91034770
73Gap junction_Homo sapiens_hsa045400.90144393
74Collecting duct acid secretion_Homo sapiens_hsa049660.89587054
75Taste transduction_Homo sapiens_hsa047420.89100325
76Long-term depression_Homo sapiens_hsa047300.88982233
77Bile secretion_Homo sapiens_hsa049760.87429249
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.86464789
79Asthma_Homo sapiens_hsa053100.86038387
80African trypanosomiasis_Homo sapiens_hsa051430.85627395
81ErbB signaling pathway_Homo sapiens_hsa040120.85092051
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84820057
83cAMP signaling pathway_Homo sapiens_hsa040240.83214491
84Shigellosis_Homo sapiens_hsa051310.82978560
85Vibrio cholerae infection_Homo sapiens_hsa051100.82297219
86Dorso-ventral axis formation_Homo sapiens_hsa043200.81448998
87Thyroid hormone synthesis_Homo sapiens_hsa049180.81171095
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.80936882
89Notch signaling pathway_Homo sapiens_hsa043300.79718651
90Bladder cancer_Homo sapiens_hsa052190.78196359
91Apoptosis_Homo sapiens_hsa042100.77606949
92Endometrial cancer_Homo sapiens_hsa052130.77346430
93Serotonergic synapse_Homo sapiens_hsa047260.76529339
94Lysosome_Homo sapiens_hsa041420.76353316
95VEGF signaling pathway_Homo sapiens_hsa043700.74598565
96Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73992142
97Dilated cardiomyopathy_Homo sapiens_hsa054140.73875994
98Pancreatic secretion_Homo sapiens_hsa049720.72639171
99Calcium signaling pathway_Homo sapiens_hsa040200.71702608
100Phospholipase D signaling pathway_Homo sapiens_hsa040720.71678613
101Herpes simplex infection_Homo sapiens_hsa051680.69854389
102Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69721477
103Chemokine signaling pathway_Homo sapiens_hsa040620.69674083
104Insulin resistance_Homo sapiens_hsa049310.68972667
105Endocytosis_Homo sapiens_hsa041440.68660051
106Vascular smooth muscle contraction_Homo sapiens_hsa042700.68622112
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66324388
108Insulin signaling pathway_Homo sapiens_hsa049100.65338993
109Melanogenesis_Homo sapiens_hsa049160.65307700
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65302297
111mTOR signaling pathway_Homo sapiens_hsa041500.62395225
112Prolactin signaling pathway_Homo sapiens_hsa049170.61878308
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59647948
114Amoebiasis_Homo sapiens_hsa051460.59587994
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59480179
116Renal cell carcinoma_Homo sapiens_hsa052110.59367487
117Platelet activation_Homo sapiens_hsa046110.59018457
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.58363694
119Butanoate metabolism_Homo sapiens_hsa006500.58047552
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.57985735
121Glycosaminoglycan degradation_Homo sapiens_hsa005310.57475929
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56798491
123MAPK signaling pathway_Homo sapiens_hsa040100.56594847
124Type I diabetes mellitus_Homo sapiens_hsa049400.55812260
125Osteoclast differentiation_Homo sapiens_hsa043800.55359934
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55336008
127Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55098960
128Focal adhesion_Homo sapiens_hsa045100.54921430
129Glucagon signaling pathway_Homo sapiens_hsa049220.54247961
130Pancreatic cancer_Homo sapiens_hsa052120.53780500
131Non-small cell lung cancer_Homo sapiens_hsa052230.53436237
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53386294
133FoxO signaling pathway_Homo sapiens_hsa040680.53076652
134PPAR signaling pathway_Homo sapiens_hsa033200.53010350
135Inositol phosphate metabolism_Homo sapiens_hsa005620.52733961
136Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52532596
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52511525
138HIF-1 signaling pathway_Homo sapiens_hsa040660.52467826
139T cell receptor signaling pathway_Homo sapiens_hsa046600.52273757
140Choline metabolism in cancer_Homo sapiens_hsa052310.52215058
141Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.51309152
142Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51303431
143Prion diseases_Homo sapiens_hsa050200.50940794
144Sulfur metabolism_Homo sapiens_hsa009200.49952072
145Sphingolipid metabolism_Homo sapiens_hsa006000.49892388
146Tuberculosis_Homo sapiens_hsa051520.49571930
147Rap1 signaling pathway_Homo sapiens_hsa040150.49543989
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.49260188
149Phototransduction_Homo sapiens_hsa047440.49207910
150Proteoglycans in cancer_Homo sapiens_hsa052050.49031175
151Primary immunodeficiency_Homo sapiens_hsa053400.47128978

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