TMEM128

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.79735006
2ribosomal small subunit assembly (GO:0000028)4.83954948
3protein deneddylation (GO:0000338)4.38266181
4cullin deneddylation (GO:0010388)4.09843709
5viral transcription (GO:0019083)4.01200236
6DNA double-strand break processing (GO:0000729)3.92811789
7ribosomal small subunit biogenesis (GO:0042274)3.89664714
8cotranslational protein targeting to membrane (GO:0006613)3.86414400
9translational termination (GO:0006415)3.85524827
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.84883990
11water-soluble vitamin biosynthetic process (GO:0042364)3.83415225
12protein targeting to ER (GO:0045047)3.78089606
13platelet dense granule organization (GO:0060155)3.76248843
14proteasome assembly (GO:0043248)3.76007270
15positive regulation of mitochondrial fission (GO:0090141)3.71047958
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.69529855
17deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.68378097
18protein localization to endoplasmic reticulum (GO:0070972)3.65305441
19antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.61663087
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.58521179
21tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54170469
22RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54170469
23termination of RNA polymerase III transcription (GO:0006386)3.43625011
24transcription elongation from RNA polymerase III promoter (GO:0006385)3.43625011
25histone H2A acetylation (GO:0043968)3.39586168
26sequestering of actin monomers (GO:0042989)3.37772320
27antigen processing and presentation via MHC class Ib (GO:0002475)3.34425542
28immunoglobulin mediated immune response (GO:0016064)3.33805641
29neutrophil activation involved in immune response (GO:0002283)3.32222977
30mitochondrial respiratory chain complex assembly (GO:0033108)3.29629646
31respiratory chain complex IV assembly (GO:0008535)3.28196977
32positive regulation of B cell differentiation (GO:0045579)3.26520895
33mannosylation (GO:0097502)3.23926670
34regulation of cellular amino acid metabolic process (GO:0006521)3.22156646
35DNA deamination (GO:0045006)3.21640958
36energy coupled proton transport, down electrochemical gradient (GO:0015985)3.18989071
37ATP synthesis coupled proton transport (GO:0015986)3.18989071
38response to pheromone (GO:0019236)3.18443703
39translational elongation (GO:0006414)3.17338786
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15448333
41intraciliary transport (GO:0042073)3.14825034
42telomere maintenance via semi-conservative replication (GO:0032201)3.14480119
43response to interferon-beta (GO:0035456)3.13782032
44signal peptide processing (GO:0006465)3.12678316
45preassembly of GPI anchor in ER membrane (GO:0016254)3.12335144
46viral life cycle (GO:0019058)3.10134426
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.08612052
48protein neddylation (GO:0045116)3.08369081
49GPI anchor metabolic process (GO:0006505)3.06787542
50regulation of cilium movement (GO:0003352)3.06096714
51nonmotile primary cilium assembly (GO:0035058)3.05338639
52protein localization to cilium (GO:0061512)3.04925057
53positive regulation of T cell mediated cytotoxicity (GO:0001916)3.04792399
54retinal cone cell development (GO:0046549)3.03797134
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.01366180
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.01366180
57cilium morphogenesis (GO:0060271)3.00345753
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.99084707
59signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.98004920
60signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.98004920
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.98004920
62cellular protein complex disassembly (GO:0043624)2.96985222
63cytochrome complex assembly (GO:0017004)2.96247356
64mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96101822
65pyrimidine nucleobase catabolic process (GO:0006208)2.95037525
66S-adenosylmethionine metabolic process (GO:0046500)2.94694207
67neural tube formation (GO:0001841)2.94465607
68organelle disassembly (GO:1903008)2.93643601
69C-terminal protein amino acid modification (GO:0018410)2.93015720
70protein-cofactor linkage (GO:0018065)2.92533608
71protein polyglutamylation (GO:0018095)2.92005641
72negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89361333
73negative regulation of ligase activity (GO:0051352)2.89361333
74anterograde synaptic vesicle transport (GO:0048490)2.88154223
75GPI anchor biosynthetic process (GO:0006506)2.87397907
76L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.86108958
77regulation of hexokinase activity (GO:1903299)2.86092271
78regulation of glucokinase activity (GO:0033131)2.86092271
79axoneme assembly (GO:0035082)2.85249364
80lymphoid progenitor cell differentiation (GO:0002320)2.84996498
81antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.84864302
82regulation of T cell mediated cytotoxicity (GO:0001914)2.83035535
83piRNA metabolic process (GO:0034587)2.82244897
84translation (GO:0006412)2.82041424
85DNA integration (GO:0015074)2.80246469
86L-fucose catabolic process (GO:0042355)2.80196663
87fucose catabolic process (GO:0019317)2.80196663
88L-fucose metabolic process (GO:0042354)2.80196663
89negative regulation of transcription by competitive promoter binding (GO:0010944)2.79212734
90chaperone-mediated protein transport (GO:0072321)2.78580363
91maturation of SSU-rRNA (GO:0030490)2.78190601
92signal transduction involved in DNA integrity checkpoint (GO:0072401)2.77970972
93signal transduction involved in DNA damage checkpoint (GO:0072422)2.77970972
94ubiquinone metabolic process (GO:0006743)2.77904832
95RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77331079
96cellular response to interferon-beta (GO:0035458)2.77181580
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.76725192
98ubiquinone biosynthetic process (GO:0006744)2.76496364
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.75954037
100signal transduction involved in cell cycle checkpoint (GO:0072395)2.75654612
101dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.75054650
102nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74394658
103metallo-sulfur cluster assembly (GO:0031163)2.72169919
104iron-sulfur cluster assembly (GO:0016226)2.72169919
105telomere maintenance via recombination (GO:0000722)2.71975917
106ribonucleoprotein complex disassembly (GO:0032988)2.70973675
107negative regulation of execution phase of apoptosis (GO:1900118)2.69733801
108mitochondrial respiratory chain complex I assembly (GO:0032981)2.69322467
109NADH dehydrogenase complex assembly (GO:0010257)2.69322467
110mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.69322467
111regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.69321084
112regulation of mitotic spindle checkpoint (GO:1903504)2.69321084
113defense response to protozoan (GO:0042832)2.69231456
114limb bud formation (GO:0060174)2.69061420
115regulation of B cell differentiation (GO:0045577)2.68545542
116olfactory bulb development (GO:0021772)2.68301420
117translational initiation (GO:0006413)2.68175620
118cornea development in camera-type eye (GO:0061303)2.67404517
119nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66698366
120C-terminal protein lipidation (GO:0006501)2.65815382
121positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.65648712
122branched-chain amino acid catabolic process (GO:0009083)2.65564977
123peroxisome fission (GO:0016559)2.64249134
124protein complex biogenesis (GO:0070271)2.63877056
125glycosphingolipid biosynthetic process (GO:0006688)2.62449499
126glycolipid biosynthetic process (GO:0009247)2.61257106
127DNA damage response, detection of DNA damage (GO:0042769)2.60918458
128DNA strand elongation involved in DNA replication (GO:0006271)2.59682122
129regulation of cellular amine metabolic process (GO:0033238)2.59048326
130exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58976974
131response to protozoan (GO:0001562)2.58479386
132positive regulation of ligase activity (GO:0051351)2.57574124
133presynaptic membrane assembly (GO:0097105)2.57542531
1347-methylguanosine mRNA capping (GO:0006370)2.56813516
135nucleoside transmembrane transport (GO:1901642)2.56047465
136ribosomal large subunit biogenesis (GO:0042273)2.55733569
137establishment of protein localization to mitochondrial membrane (GO:0090151)2.54705876
138peptidyl-histidine modification (GO:0018202)2.54683518
139nucleobase catabolic process (GO:0046113)2.53456244
140anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53234338
141regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.53195102
142behavioral response to nicotine (GO:0035095)2.53050358
143L-methionine salvage (GO:0071267)2.52947098
144L-methionine biosynthetic process (GO:0071265)2.52947098
145amino acid salvage (GO:0043102)2.52947098
146RNA capping (GO:0036260)2.52547284
1477-methylguanosine RNA capping (GO:0009452)2.52547284
148central nervous system myelination (GO:0022010)2.52293961
149axon ensheathment in central nervous system (GO:0032291)2.52293961
150nucleotide transmembrane transport (GO:1901679)2.50431869
151respiratory electron transport chain (GO:0022904)2.49620590
152GTP biosynthetic process (GO:0006183)2.49202129
153mast cell activation (GO:0045576)2.48816825
154DNA strand elongation (GO:0022616)2.48584253
155protein targeting to membrane (GO:0006612)2.46525522
156pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.46373354
157rRNA modification (GO:0000154)2.46217692
158positive regulation of interleukin-17 production (GO:0032740)2.43165615
159electron transport chain (GO:0022900)2.42922424
160regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.42880829

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.22198426
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.93044353
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.92548700
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.44948841
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41598208
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.40060424
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.26234360
8ZNF274_21170338_ChIP-Seq_K562_Hela3.19555171
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.97883003
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.94004515
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.89309536
12SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.79947055
13SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.76676673
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.74415357
15HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.73761871
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.72561577
17POU3F2_20337985_ChIP-ChIP_501MEL_Human2.68125614
18BP1_19119308_ChIP-ChIP_Hs578T_Human2.60032625
19FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.57043515
20* VDR_23849224_ChIP-Seq_CD4+_Human2.56201346
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.54616297
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.54486439
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.51374363
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.51287674
25VDR_22108803_ChIP-Seq_LS180_Human2.45168563
26MYC_18555785_ChIP-Seq_MESCs_Mouse2.42785777
27EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.41806177
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.40213450
29ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31731740
30FUS_26573619_Chip-Seq_HEK293_Human2.30038002
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.27428484
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26195529
33GBX2_23144817_ChIP-Seq_PC3_Human2.26175352
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21603128
35HOXB4_20404135_ChIP-ChIP_EML_Mouse2.19794171
36EWS_26573619_Chip-Seq_HEK293_Human2.19318306
37* ERG_20887958_ChIP-Seq_HPC-7_Mouse2.18612283
38MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13887239
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13692957
40ELK1_19687146_ChIP-ChIP_HELA_Human2.13597787
41TAF15_26573619_Chip-Seq_HEK293_Human2.10042220
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.09042136
43SCL_19346495_ChIP-Seq_HPC-7_Human2.06240480
44P300_19829295_ChIP-Seq_ESCs_Human2.05199243
45PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.01015825
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.99731937
47NOTCH1_21737748_ChIP-Seq_TLL_Human1.99525468
48* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91589651
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.88679768
50SPI1_23547873_ChIP-Seq_NB4_Human1.87069916
51FLI1_27457419_Chip-Seq_LIVER_Mouse1.82284821
52RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.81313338
53E2F7_22180533_ChIP-Seq_HELA_Human1.79195086
54* FOXP3_21729870_ChIP-Seq_TREG_Human1.78619355
55HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73068737
56DCP1A_22483619_ChIP-Seq_HELA_Human1.72833422
57* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.72646923
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.70834621
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70062565
60CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.69984087
61* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.67443962
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.62970049
63CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62599263
64* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48583887
65MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45664872
66* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45629023
67* GABP_19822575_ChIP-Seq_HepG2_Human1.44866105
68MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44029716
69THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43903696
70CBP_20019798_ChIP-Seq_JUKART_Human1.42599438
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42599438
72TTF2_22483619_ChIP-Seq_HELA_Human1.41448142
73XRN2_22483619_ChIP-Seq_HELA_Human1.41197078
74POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40869826
75SALL1_21062744_ChIP-ChIP_HESCs_Human1.40782693
76GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.40220060
77YY1_21170310_ChIP-Seq_MESCs_Mouse1.39763625
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.36582957
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.36030881
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.35119660
81TP53_22573176_ChIP-Seq_HFKS_Human1.34460300
82GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.33782834
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.32673455
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32334344
85E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29828360
86IRF1_19129219_ChIP-ChIP_H3396_Human1.29268551
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.29065936
88IRF8_27001747_Chip-Seq_BMDM_Mouse1.28730538
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.28243702
90SOX2_19829295_ChIP-Seq_ESCs_Human1.27208055
91NANOG_19829295_ChIP-Seq_ESCs_Human1.27208055
92* ELK1_22589737_ChIP-Seq_MCF10A_Human1.26609491
93NELFA_20434984_ChIP-Seq_ESCs_Mouse1.26068200
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25688106
95MYC_18940864_ChIP-ChIP_HL60_Human1.25010868
96SMAD4_21799915_ChIP-Seq_A2780_Human1.23614407
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21177712
98ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19612693
99EZH2_22144423_ChIP-Seq_EOC_Human1.19477050
100ER_23166858_ChIP-Seq_MCF-7_Human1.19250066
101FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18695057
102FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18403428
103FOXA1_25329375_ChIP-Seq_VCAP_Human1.18403428
104LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17670184
105MYB_26560356_Chip-Seq_TH2_Human1.16673544
106BCAT_22108803_ChIP-Seq_LS180_Human1.15775013
107OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15712078
108SUZ12_27294783_Chip-Seq_NPCs_Mouse1.15349189
109SMAD3_21741376_ChIP-Seq_EPCs_Human1.14986776
110MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14531353
111AR_25329375_ChIP-Seq_VCAP_Human1.14371694
112KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14367341
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13615867
114TCF4_22108803_ChIP-Seq_LS180_Human1.13488167
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.13488107
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10740817
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09425530
118NFE2_27457419_Chip-Seq_LIVER_Mouse1.09320273
119SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09015537
120FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08454129
121MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.06565774
122RNF2_27304074_Chip-Seq_NSC_Mouse1.06369861
123EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04439463
124NANOG_18555785_Chip-Seq_ESCs_Mouse1.03958453
125PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03830947
126CRX_20693478_ChIP-Seq_RETINA_Mouse1.03510207
127AR_20517297_ChIP-Seq_VCAP_Human1.01642568
128GATA1_22025678_ChIP-Seq_K562_Human1.00563157
129HTT_18923047_ChIP-ChIP_STHdh_Human1.00279467
130GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99764926
131CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99701922
132P53_22387025_ChIP-Seq_ESCs_Mouse0.99482330
133TAL1_26923725_Chip-Seq_HPCs_Mouse0.98836940
134TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98467887
135SALL4_22934838_ChIP-ChIP_CD34+_Human0.98345817
136IGF1R_20145208_ChIP-Seq_DFB_Human0.97663005
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97466176
138ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97292648
139PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96769531
140* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.96294474
141NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94708150
142NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.93909979
143PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93339777
144PIAS1_25552417_ChIP-Seq_VCAP_Human0.92178274
145GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91874838
146STAT3_23295773_ChIP-Seq_U87_Human0.91778234
147SOX2_16153702_ChIP-ChIP_HESCs_Human0.91537510
148FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.91117735
149NANOG_16153702_ChIP-ChIP_HESCs_Human0.90956996
150NCOR_22424771_ChIP-Seq_293T_Human0.90611657
151BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90567672
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90073485
153VDR_24763502_ChIP-Seq_THP-1_Human0.89733092
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.89530028
155RUNX1_22412390_ChIP-Seq_EML_Mouse0.88850390
156PHF8_20622853_ChIP-Seq_HELA_Human0.88604526
157PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88039533
158EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.87456099
159GATA3_26560356_Chip-Seq_TH2_Human0.86075412
160CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81961264
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.81925591
162MYB_26560356_Chip-Seq_TH1_Human0.81277567
163STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80843854
164PCGF2_27294783_Chip-Seq_ESCs_Mouse0.80334375
165CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.80000536
166SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.77633492
167STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.77321662
168STAT1_20625510_ChIP-Seq_HELA_Human0.77196937
169CTCF_18555785_ChIP-Seq_MESCs_Mouse0.76833046

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.79410341
2MP0005671_abnormal_response_to3.60314505
3MP0009785_altered_susceptibility_to3.43120289
4MP0006072_abnormal_retinal_apoptosis3.11267530
5MP0008877_abnormal_DNA_methylation3.02971921
6MP0000685_abnormal_immune_system2.83140913
7MP0002148_abnormal_hypersensitivity_rea2.79375452
8MP0001984_abnormal_olfaction2.75506442
9MP0009379_abnormal_foot_pigmentation2.59294887
10MP0005000_abnormal_immune_tolerance2.56230384
11MP0008789_abnormal_olfactory_epithelium2.50146666
12MP0005025_abnormal_response_to2.44954675
13MP0003724_increased_susceptibility_to2.43778960
14MP0002723_abnormal_immune_serum2.35740166
15MP0005253_abnormal_eye_physiology2.34807720
16MP0000372_irregular_coat_pigmentation2.32465165
17MP0003787_abnormal_imprinting2.30936489
18MP0001800_abnormal_humoral_immune2.28224910
19MP0002452_abnormal_antigen_presenting2.27093308
20MP0003436_decreased_susceptibility_to2.23856311
21MP0002419_abnormal_innate_immunity2.20965252
22MP0002420_abnormal_adaptive_immunity2.20568473
23MP0003195_calcinosis2.20082054
24MP0001819_abnormal_immune_cell2.18708339
25MP0001986_abnormal_taste_sensitivity2.18012277
26MP0005387_immune_system_phenotype2.16818363
27MP0001790_abnormal_immune_system2.16818363
28MP0002396_abnormal_hematopoietic_system2.14099370
29MP0004147_increased_porphyrin_level2.11895066
30MP0005394_taste/olfaction_phenotype2.08227692
31MP0005499_abnormal_olfactory_system2.08227692
32MP0005075_abnormal_melanosome_morpholog2.05455316
33MP0009333_abnormal_splenocyte_physiolog2.01378058
34MP0005551_abnormal_eye_electrophysiolog1.89090856
35MP0003763_abnormal_thymus_physiology1.88086150
36MP0001905_abnormal_dopamine_level1.85842569
37MP0002736_abnormal_nociception_after1.85757523
38MP0006292_abnormal_olfactory_placode1.85155499
39MP0005645_abnormal_hypothalamus_physiol1.84663234
40MP0006276_abnormal_autonomic_nervous1.79042492
41MP0000015_abnormal_ear_pigmentation1.78692929
42MP0002398_abnormal_bone_marrow1.77266875
43MP0000716_abnormal_immune_system1.77237199
44MP0003879_abnormal_hair_cell1.76605576
45MP0002132_abnormal_respiratory_system1.76360248
46MP0005174_abnormal_tail_pigmentation1.75864479
47MP0006082_CNS_inflammation1.74625661
48MP0003011_delayed_dark_adaptation1.69106183
49MP0001853_heart_inflammation1.68948121
50MP0001968_abnormal_touch/_nociception1.68409044
51MP0003122_maternal_imprinting1.68222399
52MP0005464_abnormal_platelet_physiology1.66497305
53MP0004133_heterotaxia1.65373929
54MP0002751_abnormal_autonomic_nervous1.65117633
55MP0003186_abnormal_redox_activity1.64906742
56MP0002095_abnormal_skin_pigmentation1.58799071
57MP0002837_dystrophic_cardiac_calcinosis1.57817211
58MP0003121_genomic_imprinting1.55848828
59MP0002429_abnormal_blood_cell1.54449880
60MP0005367_renal/urinary_system_phenotyp1.53957885
61MP0000516_abnormal_urinary_system1.53957885
62MP0002933_joint_inflammation1.52593675
63MP0001529_abnormal_vocalization1.52489714
64MP0008260_abnormal_autophagy1.51240079
65MP0003136_yellow_coat_color1.49923399
66MP0003656_abnormal_erythrocyte_physiolo1.49754605
67MP0000689_abnormal_spleen_morphology1.45710758
68MP0005397_hematopoietic_system_phenotyp1.45514819
69MP0001545_abnormal_hematopoietic_system1.45514819
70MP0000647_abnormal_sebaceous_gland1.42386810
71MP0003880_abnormal_central_pattern1.42245691
72MP0003693_abnormal_embryo_hatching1.40788295
73MP0001873_stomach_inflammation1.40658432
74MP0003866_abnormal_defecation1.39496617
75MP0002722_abnormal_immune_system1.38817736
76MP0003718_maternal_effect1.37687914
77MP0000920_abnormal_myelination1.36847890
78MP0008058_abnormal_DNA_repair1.35935694
79MP0006054_spinal_hemorrhage1.34868734
80MP0006035_abnormal_mitochondrial_morpho1.34527125
81MP0001188_hyperpigmentation1.34233325
82MP0002405_respiratory_system_inflammati1.33247741
83MP0009046_muscle_twitch1.32773886
84MP0005409_darkened_coat_color1.32599579
85MP0000681_abnormal_thyroid_gland1.32447822
86MP0002234_abnormal_pharynx_morphology1.31478504
87MP0010155_abnormal_intestine_physiology1.31125061
88MP0005646_abnormal_pituitary_gland1.30969357
89MP0010386_abnormal_urinary_bladder1.29566897
90MP0001845_abnormal_inflammatory_respons1.27809910
91MP0000490_abnormal_crypts_of1.26545264
92MP0000631_abnormal_neuroendocrine_gland1.24647418
93MP0008995_early_reproductive_senescence1.22755557
94MP0003890_abnormal_embryonic-extraembry1.21515305
95MP0008469_abnormal_protein_level1.20095168
96MP0005386_behavior/neurological_phenoty1.18420280
97MP0004924_abnormal_behavior1.18420280
98MP0001764_abnormal_homeostasis1.17893724
99MP0008057_abnormal_DNA_replication1.17454387
100MP0002090_abnormal_vision1.16385967
101MP0002006_tumorigenesis1.13887279
102MP0006036_abnormal_mitochondrial_physio1.12992288
103MP0002272_abnormal_nervous_system1.12023660
104MP0001486_abnormal_startle_reflex1.11885160
105MP0002822_catalepsy1.11350934
106MP0000427_abnormal_hair_cycle1.09618281
107MP0001929_abnormal_gametogenesis1.09578142
108MP0003137_abnormal_impulse_conducting1.08868959
109MP0005248_abnormal_Harderian_gland1.08212873
110MP0001533_abnormal_skeleton_physiology1.07937221
111MP0002166_altered_tumor_susceptibility1.07608221
112MP0009745_abnormal_behavioral_response1.03752021
113MP0002557_abnormal_social/conspecific_i1.03461744
114MP0002277_abnormal_respiratory_mucosa1.02890513
115MP0005389_reproductive_system_phenotype1.01866762
116MP0002938_white_spotting1.01550844
117MP0002876_abnormal_thyroid_physiology1.01177537
118MP0008872_abnormal_physiological_respon1.00507122
119MP0004215_abnormal_myocardial_fiber1.00073910
120MP0004142_abnormal_muscle_tone0.99887762
121MP0002210_abnormal_sex_determination0.99253915
122MP0002163_abnormal_gland_morphology0.97683987
123MP0004381_abnormal_hair_follicle0.96991993
124MP0005410_abnormal_fertilization0.95935541
125MP0005391_vision/eye_phenotype0.95479976
126MP0005451_abnormal_body_composition0.95240813
127MP0002909_abnormal_adrenal_gland0.94760600
128MP0003698_abnormal_male_reproductive0.94622705
129MP0005195_abnormal_posterior_eye0.94257339
130MP0005171_absent_coat_pigmentation0.94097011
131MP0000653_abnormal_sex_gland0.92983255
132MP0002233_abnormal_nose_morphology0.92639467
133MP0002735_abnormal_chemical_nociception0.92199858
134MP0004885_abnormal_endolymph0.91178040
135MP0001501_abnormal_sleep_pattern0.90512339
136MP0003567_abnormal_fetal_cardiomyocyte0.89110352
137MP0008007_abnormal_cellular_replicative0.89026925
138MP0000703_abnormal_thymus_morphology0.88743322
139MP0003786_premature_aging0.87932258
140MP0003077_abnormal_cell_cycle0.87152396
141MP0000049_abnormal_middle_ear0.86780322
142MP0005084_abnormal_gallbladder_morpholo0.86252645
143MP0001293_anophthalmia0.85988923
144MP0001919_abnormal_reproductive_system0.85866877
145MP0000569_abnormal_digit_pigmentation0.85829968
146MP0004947_skin_inflammation0.85670588
147MP0001145_abnormal_male_reproductive0.84802203
148MP0002572_abnormal_emotion/affect_behav0.84607502
149MP0001970_abnormal_pain_threshold0.83927304
150MP0000778_abnormal_nervous_system0.83723888
151MP0004957_abnormal_blastocyst_morpholog0.83574868
152MP0005379_endocrine/exocrine_gland_phen0.82965309
153MP0001324_abnormal_eye_pigmentation0.81557765
154MP0002160_abnormal_reproductive_system0.79733887
155MP0000465_gastrointestinal_hemorrhage0.79104487
156MP0005058_abnormal_lysosome_morphology0.78993832
157MP0001119_abnormal_female_reproductive0.77977682
158MP0002102_abnormal_ear_morphology0.77385857
159MP0009764_decreased_sensitivity_to0.77078175
160MP0008875_abnormal_xenobiotic_pharmacok0.76905611
161MP0010094_abnormal_chromosome_stability0.76047172
162MP0002752_abnormal_somatic_nervous0.75984930
163MP0004043_abnormal_pH_regulation0.75636802
164MP0002734_abnormal_mechanical_nocicepti0.75204747
165MP0010678_abnormal_skin_adnexa0.75155973
166MP0001485_abnormal_pinna_reflex0.75129054
167MP0004742_abnormal_vestibular_system0.73857071
168MP0002638_abnormal_pupillary_reflex0.72488473
169MP0008932_abnormal_embryonic_tissue0.71603674
170MP0004782_abnormal_surfactant_physiolog0.71385824
171MP0000858_altered_metastatic_potential0.71046101
172MP0005310_abnormal_salivary_gland0.70001594
173MP0000566_synostosis0.69392364
174MP0005164_abnormal_response_to0.67009987
175MP0001851_eye_inflammation0.66504889
176MP0009697_abnormal_copulation0.65215457

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.75027743
2Abnormal number of erythroid precursors (HP:0012131)4.27557583
3Abnormality of cells of the erythroid lineage (HP:0012130)4.26817421
4Type I transferrin isoform profile (HP:0003642)4.16433780
5Reduced antithrombin III activity (HP:0001976)3.83987424
6Recurrent abscess formation (HP:0002722)3.59660621
7Medial flaring of the eyebrow (HP:0010747)3.56836299
8Hepatocellular necrosis (HP:0001404)3.55088971
9Methylmalonic acidemia (HP:0002912)3.48422464
10Pancreatic cysts (HP:0001737)3.46091190
11Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.40438671
12Decreased activity of mitochondrial respiratory chain (HP:0008972)3.40438671
13Elevated erythrocyte sedimentation rate (HP:0003565)3.39053158
14Recurrent bacterial skin infections (HP:0005406)3.36797838
153-Methylglutaconic aciduria (HP:0003535)3.31043016
16Renal Fanconi syndrome (HP:0001994)3.29862177
17Mitochondrial inheritance (HP:0001427)3.25547754
18Pancreatic fibrosis (HP:0100732)3.20449976
19Abnormality of macrophages (HP:0004311)3.19499039
20Abnormality of midbrain morphology (HP:0002418)3.18713303
21Molar tooth sign on MRI (HP:0002419)3.18713303
22Increased hepatocellular lipid droplets (HP:0006565)3.16499964
23Abnormality of B cell number (HP:0010975)3.14450108
24B lymphocytopenia (HP:0010976)3.14450108
25Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.11332563
26Abnormal protein N-linked glycosylation (HP:0012347)3.11332563
27Abnormal protein glycosylation (HP:0012346)3.11332563
28Abnormal glycosylation (HP:0012345)3.11332563
29Reticulocytopenia (HP:0001896)3.10046028
30Acute necrotizing encephalopathy (HP:0006965)3.06548974
31IgG deficiency (HP:0004315)3.00015059
32Abnormality of the heme biosynthetic pathway (HP:0010472)2.99128618
33Parakeratosis (HP:0001036)2.98124922
34IgM deficiency (HP:0002850)2.98082891
35Congenital primary aphakia (HP:0007707)2.95867575
36Methylmalonic aciduria (HP:0012120)2.94265387
37Hepatic necrosis (HP:0002605)2.92109705
38Gait imbalance (HP:0002141)2.92019341
39Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.88043816
40Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.87835807
41Pallor (HP:0000980)2.87466350
42Exertional dyspnea (HP:0002875)2.85328288
43Hypothermia (HP:0002045)2.82073870
44Gastrointestinal stroma tumor (HP:0100723)2.81606670
45Nephrogenic diabetes insipidus (HP:0009806)2.77295365
46Increased CSF lactate (HP:0002490)2.76842696
47Abnormality of the labia minora (HP:0012880)2.69082415
48Abnormal mitochondria in muscle tissue (HP:0008316)2.68462520
49Hyperglycinemia (HP:0002154)2.62848173
50Lipid accumulation in hepatocytes (HP:0006561)2.62757854
51Thrombocytosis (HP:0001894)2.61842717
52Nephronophthisis (HP:0000090)2.58577477
53Macrocytic anemia (HP:0001972)2.57583748
54Chronic otitis media (HP:0000389)2.54780641
55Congenital stationary night blindness (HP:0007642)2.52495432
56Recurrent skin infections (HP:0001581)2.49478241
57Genital tract atresia (HP:0001827)2.46521108
58Petechiae (HP:0000967)2.45798281
59Recurrent bronchitis (HP:0002837)2.45354088
60Cerebral edema (HP:0002181)2.45210476
61Renal cortical cysts (HP:0000803)2.41298422
62Recurrent pneumonia (HP:0006532)2.40547835
63Mediastinal lymphadenopathy (HP:0100721)2.37315394
64Vaginal atresia (HP:0000148)2.37142029
65Intestinal atresia (HP:0011100)2.33647728
66Agammaglobulinemia (HP:0004432)2.32054248
67Pancytopenia (HP:0001876)2.31294263
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.30679616
69Progressive macrocephaly (HP:0004481)2.29656759
70Abnormality of the fovea (HP:0000493)2.28997919
71Hypoproteinemia (HP:0003075)2.28881609
72Increased intramyocellular lipid droplets (HP:0012240)2.28632870
73Abnormal biliary tract physiology (HP:0012439)2.25392022
74Bile duct proliferation (HP:0001408)2.25392022
75Sclerocornea (HP:0000647)2.24827119
76Neutropenia (HP:0001875)2.24528651
77Myositis (HP:0100614)2.22748693
78Obstructive lung disease (HP:0006536)2.22706828
79Chronic obstructive pulmonary disease (HP:0006510)2.22706828
80Aplasia/Hypoplasia of the fovea (HP:0008060)2.22441796
81Hypoplasia of the fovea (HP:0007750)2.22441796
82Type 2 muscle fiber atrophy (HP:0003554)2.22368856
83Optic disc pallor (HP:0000543)2.22366030
84Amyotrophic lateral sclerosis (HP:0007354)2.21170134
85Vasculitis (HP:0002633)2.20014168
86Stomatitis (HP:0010280)2.18865344
87Abnormal rod and cone electroretinograms (HP:0008323)2.18784095
88Abnormality of the renal cortex (HP:0011035)2.18355426
89Abnormality of vitamin B metabolism (HP:0004340)2.18007462
90Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17258049
91Meningitis (HP:0001287)2.16064820
92Poor head control (HP:0002421)2.15931045
93Hepatosplenomegaly (HP:0001433)2.15495184
94Acute encephalopathy (HP:0006846)2.15259295
95Eczematoid dermatitis (HP:0000976)2.14910120
96Increased serum lactate (HP:0002151)2.14757276
97Abolished electroretinogram (ERG) (HP:0000550)2.14415708
98Aplasia/Hypoplasia of the tongue (HP:0010295)2.13886036
99Lymphoma (HP:0002665)2.13537885
100Lymphopenia (HP:0001888)2.13098422
101Poikiloderma (HP:0001029)2.12581221
102Panhypogammaglobulinemia (HP:0003139)2.11840087
103Degeneration of anterior horn cells (HP:0002398)2.10554480
104Abnormality of the anterior horn cell (HP:0006802)2.10554480
105Abnormality of the renal medulla (HP:0100957)2.09345479
106Thyroid-stimulating hormone excess (HP:0002925)2.07037439
107Colon cancer (HP:0003003)2.05288461
108Abnormality of the vitamin B12 metabolism (HP:0004341)2.05025014
109Abnormality of renal resorption (HP:0011038)2.04384331
110Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03531187
111Respiratory failure (HP:0002878)2.03016477
112Aplasia/Hypoplasia of the sacrum (HP:0008517)2.02163910
113Abnormality of macular pigmentation (HP:0008002)2.01191306
114Recurrent sinusitis (HP:0011108)2.01133210
115Anencephaly (HP:0002323)1.99568683
116Abnormality of serine family amino acid metabolism (HP:0010894)1.99315554
117Abnormality of glycine metabolism (HP:0010895)1.99315554
118Vacuolated lymphocytes (HP:0001922)1.99212992
119Abnormality of cells of the lymphoid lineage (HP:0012140)1.98576290
120Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97387265
121Abnormality of alanine metabolism (HP:0010916)1.97387265
122Hyperalaninemia (HP:0003348)1.97387265
123Increased IgM level (HP:0003496)1.97216013
124Attenuation of retinal blood vessels (HP:0007843)1.96615810
125Metaphyseal dysplasia (HP:0100255)1.96463032
126Generalized aminoaciduria (HP:0002909)1.95448773
127Short tibia (HP:0005736)1.94826526
128Ketoacidosis (HP:0001993)1.93975496
129Recurrent lower respiratory tract infections (HP:0002783)1.93861763
130Patchy hypopigmentation of hair (HP:0011365)1.92786321
131Glycosuria (HP:0003076)1.92765495
132Abnormality of urine glucose concentration (HP:0011016)1.92765495
133Postaxial hand polydactyly (HP:0001162)1.92339826
134Muscle fiber atrophy (HP:0100295)1.92250452
135Entropion (HP:0000621)1.92050964
136Cerebral hypomyelination (HP:0006808)1.91952817
137Respiratory difficulties (HP:0002880)1.91540478
138Male pseudohermaphroditism (HP:0000037)1.90702674
139Cystic liver disease (HP:0006706)1.90087923
140Recurrent viral infections (HP:0004429)1.89306571
141Polyphagia (HP:0002591)1.88787159
142Postaxial foot polydactyly (HP:0001830)1.88020960
143Occipital encephalocele (HP:0002085)1.87519708
144Abnormality of the columella (HP:0009929)1.86624157
145Tubulointerstitial nephritis (HP:0001970)1.86539840
146Thyroiditis (HP:0100646)1.86125910
147Aplasia/Hypoplasia of the tibia (HP:0005772)1.85954644
148CNS demyelination (HP:0007305)1.85872806
149Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85050159
150Dicarboxylic aciduria (HP:0003215)1.85050159
151Abnormality of T cell physiology (HP:0011840)1.80829842
152Leukodystrophy (HP:0002415)1.80265429
153Lethargy (HP:0001254)1.80230520
154Microcytic anemia (HP:0001935)1.79918660
155Prolonged neonatal jaundice (HP:0006579)1.79865132
156Lactic acidosis (HP:0003128)1.79563051
157Abnormality of serum amino acid levels (HP:0003112)1.78885570
158Absent rod-and cone-mediated responses on ERG (HP:0007688)1.78240143
159Purpura (HP:0000979)1.78094206
160Aplasia/hypoplasia of the uterus (HP:0008684)1.77409393
161Birth length less than 3rd percentile (HP:0003561)1.77358835
162Chronic mucocutaneous candidiasis (HP:0002728)1.76175775
163Recurrent cutaneous fungal infections (HP:0011370)1.76175775
164Increased muscle lipid content (HP:0009058)1.75717180
165Retinal dysplasia (HP:0007973)1.75655615
166True hermaphroditism (HP:0010459)1.75462002
167Abnormality of the prostate (HP:0008775)1.75419650
168Recurrent fungal infections (HP:0002841)1.74900250
169Preaxial hand polydactyly (HP:0001177)1.73952048
170Ketosis (HP:0001946)1.72631286
171Decreased testicular size (HP:0008734)1.71882715
172Congenital hepatic fibrosis (HP:0002612)1.71728985
173Abnormality of aspartate family amino acid metabolism (HP:0010899)1.71571901
174Dyskinesia (HP:0100660)1.71031775
175Broad foot (HP:0001769)1.70679344
176Progressive inability to walk (HP:0002505)1.69083958

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK24.17391254
2MAP4K23.72537896
3TNIK3.29490638
4NME23.27726183
5TRIM283.21997751
6FRK3.18340223
7STK162.93317021
8ACVR1B2.62192503
9WNK32.45467487
10NUAK12.31061610
11PINK12.25834527
12TXK2.25764994
13EIF2AK32.25253180
14CDK192.22999510
15MAP4K12.18735646
16KIT2.15907407
17MUSK2.09697456
18PIM22.07589393
19MAP3K122.06989926
20PBK1.98824778
21MAP3K41.95450119
22TEC1.94724759
23MST41.90519169
24BUB11.80406028
25CSNK1G21.76150939
26CAMK1D1.75049403
27VRK11.72224823
28IRAK41.72167581
29BCKDK1.69873823
30EIF2AK11.62685364
31TBK11.62371566
32MAP3K141.59440305
33WEE11.57153408
34ZAK1.56427969
35CSNK1A1L1.55903280
36RIPK41.49503011
37PLK21.48376633
38IRAK31.47773924
39CCNB11.42419660
40ARAF1.42010300
41MAPK131.37218963
42BTK1.36583379
43BMPR21.36353677
44VRK21.36220431
45NLK1.34683650
46MKNK11.32009489
47JAK31.28709511
48IKBKB1.22679858
49EPHA41.16404525
50MAP2K71.13209931
51PLK31.12684688
52CLK11.12412246
53MAPKAPK51.10019310
54IKBKE1.09033260
55MARK11.08672961
56CSF1R1.08613679
57RPS6KA41.07235876
58TYK21.05771931
59PAK31.04663273
60LYN1.04451110
61KDR1.04344249
62SYK1.04327786
63BLK1.04250380
64TLK11.01573127
65NEK11.00029810
66OXSR10.97490568
67EIF2AK20.97465730
68PDK20.93923392
69ADRBK20.92595687
70PRKCE0.89073828
71STK390.86024877
72CASK0.85958990
73TIE10.85047171
74MAP3K110.84356379
75BMPR1B0.81854543
76ZAP700.81810943
77NME10.79768190
78LCK0.78576120
79BRSK20.76953251
80FLT30.75374121
81PLK10.74616338
82GRK70.74097742
83INSRR0.73188526
84MKNK20.72888832
85STK38L0.72678271
86FGFR20.72525355
87MINK10.71202414
88TAF10.68071816
89LIMK10.67386786
90CAMK1G0.66788775
91DYRK20.66663766
92TESK20.62352699
93CAMK10.60288379
94CSNK1G30.59690877
95DAPK10.58704263
96PRKCG0.58359555
97DYRK30.58353064
98ITK0.57745879
99STK30.57307096
100SRPK10.56669874
101SIK30.55357527
102RPS6KA50.55119269
103ABL20.54214897
104FER0.53396127
105EPHA30.52421847
106MYLK0.51334451
107YES10.50642082
108CAMKK10.49414928
109PHKG20.49128011
110PHKG10.49128011
111MAPK150.47795011
112MAP2K30.47080112
113KSR10.46050164
114MATK0.45645843
115CAMK2A0.44737588
116BRAF0.44319472
117FES0.44254972
118CSNK1A10.44179864
119LRRK20.44139531
120RAF10.43017454
121TAOK30.42988353
122STK40.42985016
123PIM10.42888419
124PLK40.42521325
125TESK10.42349832
126WNK40.41576514
127MAPK40.40333891
128PKN10.39504416
129BCR0.38974376
130PRKG20.38179812
131ADRBK10.37857955
132NTRK20.37455543
133ERBB30.37169427
134PRKCD0.36708872
135NEK60.36243730
136PASK0.35530597
137STK240.35283676
138CSNK2A10.34850040
139MAP3K90.34676339
140PRKACA0.33944044
141TGFBR10.33859673
142ATR0.33839125
143ATM0.33773769
144MAP3K50.33414335
145DAPK20.32179641
146CSNK1G10.32159059
147FGR0.31178868
148MAP3K130.31050837
149GRK10.30480690
150MARK30.28729778

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.09023235
2Proteasome_Homo sapiens_hsa030503.92338693
3RNA polymerase_Homo sapiens_hsa030203.00226082
4DNA replication_Homo sapiens_hsa030302.99065502
5Protein export_Homo sapiens_hsa030602.95377653
6Oxidative phosphorylation_Homo sapiens_hsa001902.74412514
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.67168568
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.57679671
9Mismatch repair_Homo sapiens_hsa034302.54632506
10Homologous recombination_Homo sapiens_hsa034402.33711203
11Propanoate metabolism_Homo sapiens_hsa006402.26640226
12Parkinsons disease_Homo sapiens_hsa050122.23990024
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.04061902
14Butanoate metabolism_Homo sapiens_hsa006502.03448999
15Pyrimidine metabolism_Homo sapiens_hsa002401.98112338
16Primary immunodeficiency_Homo sapiens_hsa053401.94360180
17Phototransduction_Homo sapiens_hsa047441.88461638
18Base excision repair_Homo sapiens_hsa034101.85807418
19Nucleotide excision repair_Homo sapiens_hsa034201.82562524
20Non-homologous end-joining_Homo sapiens_hsa034501.73321665
21Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.73184296
22Allograft rejection_Homo sapiens_hsa053301.71997294
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.69723120
24Graft-versus-host disease_Homo sapiens_hsa053321.64813239
25Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.60859945
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58075588
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56621005
28Huntingtons disease_Homo sapiens_hsa050161.55517096
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.52388195
30Alzheimers disease_Homo sapiens_hsa050101.50118584
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49856950
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42515488
33Basal transcription factors_Homo sapiens_hsa030221.41594156
34Rheumatoid arthritis_Homo sapiens_hsa053231.40383603
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.40223643
36Spliceosome_Homo sapiens_hsa030401.38524956
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.36453612
38Peroxisome_Homo sapiens_hsa041461.34259906
39Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.32719907
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28218413
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26044585
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.24246790
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.22946162
44Nitrogen metabolism_Homo sapiens_hsa009101.18503843
45Leishmaniasis_Homo sapiens_hsa051401.17127445
46Hematopoietic cell lineage_Homo sapiens_hsa046401.15815231
47Fatty acid elongation_Homo sapiens_hsa000621.14722734
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14516732
49Antigen processing and presentation_Homo sapiens_hsa046121.10801308
50Purine metabolism_Homo sapiens_hsa002301.10408667
51Autoimmune thyroid disease_Homo sapiens_hsa053201.09777653
52RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09540943
53Sphingolipid metabolism_Homo sapiens_hsa006001.08439685
54Asthma_Homo sapiens_hsa053101.01612429
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99507040
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.98809275
57Nicotine addiction_Homo sapiens_hsa050330.98047804
58Steroid biosynthesis_Homo sapiens_hsa001000.96673052
59NOD-like receptor signaling pathway_Homo sapiens_hsa046210.96489197
60Malaria_Homo sapiens_hsa051440.94520612
61Ether lipid metabolism_Homo sapiens_hsa005650.94467786
62Tryptophan metabolism_Homo sapiens_hsa003800.94405024
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94362392
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.94299015
65Measles_Homo sapiens_hsa051620.93062546
66Cardiac muscle contraction_Homo sapiens_hsa042600.92733392
67Fanconi anemia pathway_Homo sapiens_hsa034600.90209204
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.89349959
69Folate biosynthesis_Homo sapiens_hsa007900.89137198
70Herpes simplex infection_Homo sapiens_hsa051680.89120616
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88552798
72RNA degradation_Homo sapiens_hsa030180.88039949
73Vitamin B6 metabolism_Homo sapiens_hsa007500.87997113
74Pertussis_Homo sapiens_hsa051330.87284808
75beta-Alanine metabolism_Homo sapiens_hsa004100.85856329
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.84979651
77Type I diabetes mellitus_Homo sapiens_hsa049400.84423463
78Phagosome_Homo sapiens_hsa041450.81627159
79Collecting duct acid secretion_Homo sapiens_hsa049660.81612774
80Legionellosis_Homo sapiens_hsa051340.81262799
81Epstein-Barr virus infection_Homo sapiens_hsa051690.80803109
82Arachidonic acid metabolism_Homo sapiens_hsa005900.76789877
83Selenocompound metabolism_Homo sapiens_hsa004500.74474683
84Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74392328
85Chemical carcinogenesis_Homo sapiens_hsa052040.74318240
86Toll-like receptor signaling pathway_Homo sapiens_hsa046200.73559329
87Pyruvate metabolism_Homo sapiens_hsa006200.73016663
88alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72600490
89Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71663475
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.71502936
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71439480
92Other glycan degradation_Homo sapiens_hsa005110.71258575
93Shigellosis_Homo sapiens_hsa051310.70712264
94RNA transport_Homo sapiens_hsa030130.70448357
95Regulation of autophagy_Homo sapiens_hsa041400.69886071
96Glutathione metabolism_Homo sapiens_hsa004800.69279231
97Oocyte meiosis_Homo sapiens_hsa041140.69224048
98Vibrio cholerae infection_Homo sapiens_hsa051100.68942805
99Salmonella infection_Homo sapiens_hsa051320.68232421
100N-Glycan biosynthesis_Homo sapiens_hsa005100.67945942
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.67590401
102Olfactory transduction_Homo sapiens_hsa047400.66239473
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64711174
104Jak-STAT signaling pathway_Homo sapiens_hsa046300.64099044
105Fatty acid metabolism_Homo sapiens_hsa012120.63925271
106One carbon pool by folate_Homo sapiens_hsa006700.63014505
107Caffeine metabolism_Homo sapiens_hsa002320.60161112
108Tuberculosis_Homo sapiens_hsa051520.58611256
109African trypanosomiasis_Homo sapiens_hsa051430.58132999
110Taste transduction_Homo sapiens_hsa047420.56346220
111Cell cycle_Homo sapiens_hsa041100.56310969
112GABAergic synapse_Homo sapiens_hsa047270.55031432
113B cell receptor signaling pathway_Homo sapiens_hsa046620.54625391
114Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53398963
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52219134
116Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52020946
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.50986895
118Sulfur relay system_Homo sapiens_hsa041220.50634044
119Metabolic pathways_Homo sapiens_hsa011000.50375996
120Steroid hormone biosynthesis_Homo sapiens_hsa001400.47745150
121Influenza A_Homo sapiens_hsa051640.47430122
122p53 signaling pathway_Homo sapiens_hsa041150.47372634
123Fatty acid degradation_Homo sapiens_hsa000710.47305626
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46296937
125Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45828113
126Osteoclast differentiation_Homo sapiens_hsa043800.45360155
127Systemic lupus erythematosus_Homo sapiens_hsa053220.44961378
128Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.41703945
129Apoptosis_Homo sapiens_hsa042100.41120107
130Retinol metabolism_Homo sapiens_hsa008300.39727256
131Pentose phosphate pathway_Homo sapiens_hsa000300.38150689
132Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37494061
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.37387439
134Lysosome_Homo sapiens_hsa041420.37298001
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.35119171
136Linoleic acid metabolism_Homo sapiens_hsa005910.34764988
137Chemokine signaling pathway_Homo sapiens_hsa040620.32891552
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32480578
139Circadian rhythm_Homo sapiens_hsa047100.29861567
140Synaptic vesicle cycle_Homo sapiens_hsa047210.29466130
141TNF signaling pathway_Homo sapiens_hsa046680.28418022
142Drug metabolism - other enzymes_Homo sapiens_hsa009830.28132537
143Sulfur metabolism_Homo sapiens_hsa009200.27758708
144Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.26145232
145T cell receptor signaling pathway_Homo sapiens_hsa046600.26058031
146Vitamin digestion and absorption_Homo sapiens_hsa049770.25055623

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