TMEM129

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-serine metabolic process (GO:0006563)5.08610421
2negative regulation of erythrocyte differentiation (GO:0045647)4.37580175
3alpha-linolenic acid metabolic process (GO:0036109)4.31722752
4low-density lipoprotein particle remodeling (GO:0034374)4.14425067
5very long-chain fatty acid metabolic process (GO:0000038)4.03463825
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.03067234
7L-phenylalanine catabolic process (GO:0006559)4.03067234
8serine family amino acid biosynthetic process (GO:0009070)4.01790561
9proline biosynthetic process (GO:0006561)3.98179121
10protein retention in ER lumen (GO:0006621)3.92428373
11regulation of cholesterol biosynthetic process (GO:0045540)3.90766984
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79510590
13L-phenylalanine metabolic process (GO:0006558)3.79510590
14doxorubicin metabolic process (GO:0044598)3.77726184
15daunorubicin metabolic process (GO:0044597)3.77726184
16polyketide metabolic process (GO:0030638)3.77726184
17mannose metabolic process (GO:0006013)3.73171547
18tricarboxylic acid cycle (GO:0006099)3.69541811
19barbed-end actin filament capping (GO:0051016)3.67963643
20cysteine metabolic process (GO:0006534)3.65259196
21purine ribonucleotide transport (GO:0015868)3.63987849
22maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.58037012
23planar cell polarity pathway involved in neural tube closure (GO:0090179)3.55932169
24negative regulation of cell size (GO:0045792)3.53479434
25cellular modified amino acid catabolic process (GO:0042219)3.51943679
26regulation of cholesterol metabolic process (GO:0090181)3.51024864
27adherens junction assembly (GO:0034333)3.50401328
28apoptotic process involved in morphogenesis (GO:0060561)3.48474467
29mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47380465
30mitochondrial respiratory chain complex I assembly (GO:0032981)3.47380465
31NADH dehydrogenase complex assembly (GO:0010257)3.47380465
32sulfur amino acid catabolic process (GO:0000098)3.46858722
33positive regulation of triglyceride biosynthetic process (GO:0010867)3.45735521
34regulation of early endosome to late endosome transport (GO:2000641)3.44248952
35negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43198472
36nucleotide transmembrane transport (GO:1901679)3.43155846
37focal adhesion assembly (GO:0048041)3.42839665
38cell-substrate adherens junction assembly (GO:0007045)3.42839665
39regulation of glucose import in response to insulin stimulus (GO:2001273)3.41931102
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.39074242
41high-density lipoprotein particle remodeling (GO:0034375)3.37407081
42aspartate family amino acid catabolic process (GO:0009068)3.36085439
43protein localization to endosome (GO:0036010)3.35312117
44fatty acid elongation (GO:0030497)3.33009240
45retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.31836251
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31630998
47reverse cholesterol transport (GO:0043691)3.30865884
48nucleotide transport (GO:0006862)3.25526707
49acyl-CoA biosynthetic process (GO:0071616)3.25041721
50thioester biosynthetic process (GO:0035384)3.25041721
51regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.24844331
52plasma lipoprotein particle remodeling (GO:0034369)3.23917582
53protein-lipid complex remodeling (GO:0034368)3.23917582
54macromolecular complex remodeling (GO:0034367)3.23917582
55regulation of mammary gland epithelial cell proliferation (GO:0033599)3.22241972
56heme transport (GO:0015886)3.21585219
57oxaloacetate metabolic process (GO:0006107)3.20662866
58regulation of extracellular matrix disassembly (GO:0010715)3.19167745
59negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.17005539
60purine nucleotide transport (GO:0015865)3.15263744
61L-methionine salvage (GO:0071267)3.14210928
62L-methionine biosynthetic process (GO:0071265)3.14210928
63amino acid salvage (GO:0043102)3.14210928
64NADH metabolic process (GO:0006734)3.13031813
65lysine catabolic process (GO:0006554)3.12232871
66lysine metabolic process (GO:0006553)3.12232871
67signal peptide processing (GO:0006465)3.11979463
68folic acid transport (GO:0015884)3.09660414
69homocysteine metabolic process (GO:0050667)3.09590443
70ethanol oxidation (GO:0006069)3.09452229
71fatty acid beta-oxidation (GO:0006635)3.08521581
72cellular ketone body metabolic process (GO:0046950)3.07073637
73basement membrane organization (GO:0071711)3.05891527
74UV protection (GO:0009650)3.03656697
75lipid oxidation (GO:0034440)3.03510026
76cytoskeletal anchoring at plasma membrane (GO:0007016)3.03376509
77response to misfolded protein (GO:0051788)3.02389777
78bile acid biosynthetic process (GO:0006699)3.00744430
79long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.00518572
80negative regulation of response to reactive oxygen species (GO:1901032)3.00244590
81succinate metabolic process (GO:0006105)3.00075299
82stress fiber assembly (GO:0043149)2.99655088
83fatty-acyl-CoA biosynthetic process (GO:0046949)2.99380568
842-oxoglutarate metabolic process (GO:0006103)2.98742818
85aggressive behavior (GO:0002118)2.97715818
86proline metabolic process (GO:0006560)2.95929119
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.95535202
88valine metabolic process (GO:0006573)2.92671039
89activation of Rac GTPase activity (GO:0032863)2.92145984
90semaphorin-plexin signaling pathway (GO:0071526)2.91719105
91cell-substrate junction assembly (GO:0007044)2.91235171
92purine nucleotide salvage (GO:0032261)2.89894343
93fatty acid oxidation (GO:0019395)2.89831317
94adenine nucleotide transport (GO:0051503)2.89419437
95carnitine metabolic process (GO:0009437)2.89269345
96tricarboxylic acid metabolic process (GO:0072350)2.88575774
97glucosamine-containing compound catabolic process (GO:1901072)2.86395802
98fatty acid catabolic process (GO:0009062)2.85916097
99branched-chain amino acid catabolic process (GO:0009083)2.85728995
100maternal placenta development (GO:0001893)2.84979053
101glyoxylate metabolic process (GO:0046487)2.83399964
102regulation of cholesterol esterification (GO:0010872)2.83111374
103monocarboxylic acid catabolic process (GO:0072329)2.79164727
104protein complex biogenesis (GO:0070271)2.79115344
105negative regulation of myotube differentiation (GO:0010832)2.77639138
106DNA deamination (GO:0045006)2.77592867
107mitochondrial respiratory chain complex assembly (GO:0033108)2.76939469
108L-serine transport (GO:0015825)2.76687831
109epithelial cell differentiation involved in prostate gland development (GO:0060742)2.76037905
110short-chain fatty acid metabolic process (GO:0046459)2.75751101
111regulation of cholesterol homeostasis (GO:2000188)2.74877695
112response to lead ion (GO:0010288)2.74628097
113purine-containing compound salvage (GO:0043101)2.74210550
114negative regulation of fatty acid transport (GO:2000192)2.74103724
115amino-acid betaine metabolic process (GO:0006577)2.72955758
116pentose-phosphate shunt (GO:0006098)2.72028219
117positive regulation of Cdc42 GTPase activity (GO:0043089)2.71172355
118COPI coating of Golgi vesicle (GO:0048205)2.70252579
119Golgi transport vesicle coating (GO:0048200)2.70252579
120response to laminar fluid shear stress (GO:0034616)2.70228788
121acyl-CoA metabolic process (GO:0006637)2.69561456
122thioester metabolic process (GO:0035383)2.69561456
123cell-cell junction maintenance (GO:0045217)2.68316226
124regulation of triglyceride biosynthetic process (GO:0010866)2.68186521
125cellular response to exogenous dsRNA (GO:0071360)2.68173514
126aromatic amino acid family catabolic process (GO:0009074)2.67751605
127regulation of hydrogen peroxide-induced cell death (GO:1903205)2.67745461
128positive regulation of triglyceride metabolic process (GO:0090208)2.67080948
129endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.67038377
130peroxisome fission (GO:0016559)2.66682140
131carbohydrate derivative transport (GO:1901264)2.65560117
132vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.65532931
133glucose catabolic process (GO:0006007)2.65102432
134plasma lipoprotein particle organization (GO:0071827)2.63425359
135epithelial cell-cell adhesion (GO:0090136)2.63396318
136central nervous system myelination (GO:0022010)2.62950140
137axon ensheathment in central nervous system (GO:0032291)2.62950140
138positive regulation of receptor recycling (GO:0001921)2.62541272
139cholesterol biosynthetic process (GO:0006695)2.61384783
140regulation of interferon-beta biosynthetic process (GO:0045357)2.61128449
141NAD metabolic process (GO:0019674)2.59681620
142apoptotic cell clearance (GO:0043277)2.58724587
143modulation by symbiont of host cellular process (GO:0044068)2.55991993
144atrioventricular valve morphogenesis (GO:0003181)2.54636000
145adenosine receptor signaling pathway (GO:0001973)2.53857855
146pinocytosis (GO:0006907)2.53524622
147positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.51000340
148protein carboxylation (GO:0018214)2.50368405
149peptidyl-glutamic acid carboxylation (GO:0017187)2.50368405
150amyloid precursor protein catabolic process (GO:0042987)2.50091058
151protein targeting to plasma membrane (GO:0072661)2.49677564
152modulation by virus of host morphology or physiology (GO:0019048)2.46067005
153activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.45408323
154positive regulation of protein dephosphorylation (GO:0035307)2.45331466
155positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.43451189
156embryo implantation (GO:0007566)2.42095580
157activation of MAPKKK activity (GO:0000185)2.41443730
158peptidyl-tyrosine autophosphorylation (GO:0038083)2.41137882
159regulation of ARF protein signal transduction (GO:0032012)2.40651154
160negative regulation of viral release from host cell (GO:1902187)2.39580603
161creatine metabolic process (GO:0006600)2.39471466
162modulation by virus of host process (GO:0019054)2.37976719
163regulation of fatty acid beta-oxidation (GO:0031998)2.37602055
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.37358185
165apoptotic process involved in development (GO:1902742)2.32598021
166positive regulation of nuclease activity (GO:0032075)2.31354760
167cell volume homeostasis (GO:0006884)2.30909288
168GDP-mannose metabolic process (GO:0019673)2.30755985
169positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.30668884
170glutamine family amino acid biosynthetic process (GO:0009084)2.30457316
171regulation of extracellular matrix organization (GO:1903053)2.29806686
172regulation of ARF GTPase activity (GO:0032312)2.29776740
173negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.28688354
174urea cycle (GO:0000050)2.27170537
175positive regulation of histone deacetylation (GO:0031065)2.26511472
176G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.25281971
177cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.24968056
178positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24011304
179sodium ion export (GO:0071436)2.21794708
180negative regulation of catenin import into nucleus (GO:0035414)2.21362973
181glucose 6-phosphate metabolic process (GO:0051156)2.19623516
182regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.19377158
183intracellular estrogen receptor signaling pathway (GO:0030520)2.19162431
184adhesion of symbiont to host (GO:0044406)2.18787295
185regulation of apoptotic process involved in morphogenesis (GO:1902337)2.18716648
186negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.18272402
187insulin-like growth factor receptor signaling pathway (GO:0048009)2.18225717
188low-density lipoprotein particle clearance (GO:0034383)2.16774088
189NADPH regeneration (GO:0006740)2.16383868
190regulation of glucocorticoid metabolic process (GO:0031943)2.16198239
191activation of JUN kinase activity (GO:0007257)2.15846992
192vascular endothelial growth factor signaling pathway (GO:0038084)2.14137424
193amyloid precursor protein metabolic process (GO:0042982)2.12772620

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.44714404
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.19944499
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.42701709
4CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.33120823
5LXR_22292898_ChIP-Seq_THP-1_Human3.09847706
6SRF_21415370_ChIP-Seq_HL-1_Mouse3.07196791
7PPARA_22158963_ChIP-Seq_LIVER_Mouse2.96109205
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.87769657
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.87402777
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.86569873
11PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.83046501
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.80933219
13* VDR_21846776_ChIP-Seq_THP-1_Human2.77766357
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.75441975
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73151574
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.49142862
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.48032218
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46035300
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.45471774
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.45075002
21GATA1_22025678_ChIP-Seq_K562_Human2.44467037
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.41572552
23RACK7_27058665_Chip-Seq_MCF-7_Human2.40121541
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.38034002
25TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.37266408
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.34923758
27EGR1_23403033_ChIP-Seq_LIVER_Mouse2.32504476
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.24686005
29MYC_22102868_ChIP-Seq_BL_Human2.23984864
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09137733
31* HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.08306070
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07446511
33* KDM2B_26808549_Chip-Seq_DND41_Human2.02714985
34LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.99642119
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98619294
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.93226498
37TCF7_22412390_ChIP-Seq_EML_Mouse1.90889944
38ZNF263_19887448_ChIP-Seq_K562_Human1.89235820
39* KDM2B_26808549_Chip-Seq_K562_Human1.88965586
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86213499
41* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.81405213
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.80744874
43P68_20966046_ChIP-Seq_HELA_Human1.80476688
44GABP_17652178_ChIP-ChIP_JURKAT_Human1.80308142
45ESR2_21235772_ChIP-Seq_MCF-7_Human1.80059177
46TET1_21451524_ChIP-Seq_MESCs_Mouse1.77124613
47ZFP281_18757296_ChIP-ChIP_E14_Mouse1.73237962
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.73169714
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.72485174
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71978448
51* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69454852
52EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66627926
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.65481937
54UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.64170672
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.64037824
56CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62352552
57ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.61542443
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.58724327
59SMC4_20622854_ChIP-Seq_HELA_Human1.57348442
60ERG_20887958_ChIP-Seq_HPC-7_Mouse1.53260824
61ETS1_20019798_ChIP-Seq_JURKAT_Human1.52546816
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.52355829
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50858461
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.49601000
65SCL_19346495_ChIP-Seq_HPC-7_Human1.49575690
66DNAJC2_21179169_ChIP-ChIP_NT2_Human1.48522150
67RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48494826
68CREB1_26743006_Chip-Seq_LNCaP_Human1.46290258
69DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.45664424
70RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.44734275
71EST1_17652178_ChIP-ChIP_JURKAT_Human1.44055774
72SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.43700948
73VDR_24763502_ChIP-Seq_THP-1_Human1.43351313
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.43185748
75KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41909730
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41107924
77KDM2B_26808549_Chip-Seq_JURKAT_Human1.40544999
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40472681
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.38750782
80MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.37992055
81GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36986953
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.36545107
83CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.36265036
84E2F1_18555785_ChIP-Seq_MESCs_Mouse1.35230323
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.34901609
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34334285
87STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33867872
88CTCF_27219007_Chip-Seq_Bcells_Human1.31343009
89TBX5_21415370_ChIP-Seq_HL-1_Mouse1.31058163
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30083562
91GABP_19822575_ChIP-Seq_HepG2_Human1.29654026
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.26153247
93MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.25542658
94* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25032804
95EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.24295897
96* MAF_26560356_Chip-Seq_TH2_Human1.23270105
97BCL6_27268052_Chip-Seq_Bcells_Human1.22774806
98MAF_26560356_Chip-Seq_TH1_Human1.22669062
99BCOR_27268052_Chip-Seq_Bcells_Human1.22421528
100TRIM28_21343339_ChIP-Seq_HEK293_Human1.21291375
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.21126615
102DCP1A_22483619_ChIP-Seq_HELA_Human1.20549840
103* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20166393
104* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18037403
105NCOR1_26117541_ChIP-Seq_K562_Human1.17867330
106TP53_22127205_ChIP-Seq_IMR90_Human1.17773066
107ATF3_27146783_Chip-Seq_COLON_Human1.16217033
108LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.15940700
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15716999
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.15272583
111* FOXP3_21729870_ChIP-Seq_TREG_Human1.13715503
112MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.12732080
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.12729568
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.12415704
115GATA1_19941827_ChIP-Seq_MEL_Mouse1.11148069
116UTX_26944678_Chip-Seq_JUKART_Human1.10321613
117RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.09875783
118BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09735416
119TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09582395
120ELF1_20517297_ChIP-Seq_JURKAT_Human1.09457204
121CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09327818
122CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09164117
123RUNX1_27514584_Chip-Seq_MCF-7_Human1.08810997
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.08643187
125GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.07848241
126SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.07723923
127AR_20517297_ChIP-Seq_VCAP_Human1.07241844
128CLOCK_20551151_ChIP-Seq_293T_Human1.06699797
129RUNX1_22412390_ChIP-Seq_EML_Mouse1.06649093
130TP63_22573176_ChIP-Seq_HFKS_Human1.05610694
131ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05607124
132RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05422228
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05204316
134HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.04453508
135HOXB4_20404135_ChIP-ChIP_EML_Mouse1.04235477
136CTCF_21964334_Chip-Seq_Bcells_Human1.03812591
137HTT_18923047_ChIP-ChIP_STHdh_Human1.03255371
138RARA_24833708_ChIP-Seq_LIVER_Mouse1.03130243
139* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.02350061
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.02330487
141BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01598485
142KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01440912
143CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01440770
144GATA4_21415370_ChIP-Seq_HL-1_Mouse1.00629540
145SA1_27219007_Chip-Seq_Bcells_Human0.99751579
146SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99348040
147CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.99281852
148TET1_21490601_ChIP-Seq_MESCs_Mouse0.98852059
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98084022
150RARB_24833708_ChIP-Seq_LIVER_Mouse0.97659076
151SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97090011
152SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96065072
153STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.95407920
154VDR_23849224_ChIP-Seq_CD4+_Human0.93265445
155ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92396007
156ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91746898
157DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91177919
158YY1_21170310_ChIP-Seq_MESCs_Mouse0.91137832
159ERG_20517297_ChIP-Seq_VCAP_Human0.90992931
160PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88707155
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.87609591
162CTCF_26484167_Chip-Seq_Bcells_Mouse0.87381293
163PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86612343
164AR_21909140_ChIP-Seq_LNCAP_Human0.86027486
165TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.85980101
166PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85852390
167* CTCF_20526341_ChIP-Seq_ESCs_Human0.85757664
168SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.85742409
169NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84422841
170IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83213580
171CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.80284747
172RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80273982
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79692207
174OCT4_20526341_ChIP-Seq_ESCs_Human0.78767015
175IRF8_22096565_ChIP-ChIP_GC-B_Human0.78686408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis3.88837983
2MP0003878_abnormal_ear_physiology3.73425696
3MP0005377_hearing/vestibular/ear_phenot3.73425696
4MP0005360_urolithiasis3.65051947
5MP0006054_spinal_hemorrhage3.62756197
6MP0005451_abnormal_body_composition3.61502123
7MP0009840_abnormal_foam_cell3.58454922
8MP0005365_abnormal_bile_salt3.49212929
9MP0009384_cardiac_valve_regurgitation2.91976550
10MP0008875_abnormal_xenobiotic_pharmacok2.83085882
11MP0005332_abnormal_amino_acid2.81731464
12MP0001849_ear_inflammation2.80924939
13MP0002139_abnormal_hepatobiliary_system2.46709768
14MP0004885_abnormal_endolymph2.42262564
15MP0003279_aneurysm2.30795873
16MP0005085_abnormal_gallbladder_physiolo2.28490986
17MP0003186_abnormal_redox_activity2.23761715
18MP0006036_abnormal_mitochondrial_physio2.20215506
19MP0010234_abnormal_vibrissa_follicle2.16307060
20MP0003690_abnormal_glial_cell2.15865503
21MP0008260_abnormal_autophagy2.10686658
22MP0001958_emphysema2.10359313
23MP0002249_abnormal_larynx_morphology2.08632923
24MP0001764_abnormal_homeostasis2.08393310
25MP0003656_abnormal_erythrocyte_physiolo2.06371254
26MP0004185_abnormal_adipocyte_glucose2.03880140
27MP0004043_abnormal_pH_regulation2.02966961
28MP0003566_abnormal_cell_adhesion2.02289566
29MP0009697_abnormal_copulation2.01634330
30MP0004147_increased_porphyrin_level2.01342842
31MP0005083_abnormal_biliary_tract1.94217660
32MP0003329_amyloid_beta_deposits1.89866324
33MP0003191_abnormal_cellular_cholesterol1.89484741
34MP0005257_abnormal_intraocular_pressure1.88911610
35MP0005409_darkened_coat_color1.88622385
36MP0000678_abnormal_parathyroid_gland1.87015289
37MP0005076_abnormal_cell_differentiation1.81838996
38MP0005666_abnormal_adipose_tissue1.81371405
39MP0005584_abnormal_enzyme/coenzyme_acti1.75787364
40MP0009278_abnormal_bone_marrow1.72628263
41MP0003453_abnormal_keratinocyte_physiol1.69747354
42MP0005058_abnormal_lysosome_morphology1.65703298
43MP0001905_abnormal_dopamine_level1.61000411
44MP0010368_abnormal_lymphatic_system1.58405700
45MP0002837_dystrophic_cardiac_calcinosis1.57701244
46MP0010030_abnormal_orbit_morphology1.57588407
47MP0001529_abnormal_vocalization1.55450349
48MP0004272_abnormal_basement_membrane1.53797161
49MP0010329_abnormal_lipoprotein_level1.50526756
50MP0004084_abnormal_cardiac_muscle1.49581004
51MP0005375_adipose_tissue_phenotype1.49041099
52MP0003091_abnormal_cell_migration1.47458021
53MP0001502_abnormal_circadian_rhythm1.46117001
54MP0003011_delayed_dark_adaptation1.44856787
55MP0006138_congestive_heart_failure1.44341837
56MP0001661_extended_life_span1.44265082
57MP0004233_abnormal_muscle_weight1.42576227
58MP0000003_abnormal_adipose_tissue1.41306935
59MP0002877_abnormal_melanocyte_morpholog1.40542257
60MP0003300_gastrointestinal_ulcer1.37343218
61MP0004130_abnormal_muscle_cell1.37157175
62MP0000749_muscle_degeneration1.37017632
63MP0005670_abnormal_white_adipose1.34539953
64MP0005623_abnormal_meninges_morphology1.33105071
65MP0000858_altered_metastatic_potential1.30874280
66MP0002118_abnormal_lipid_homeostasis1.28677616
67MP0003436_decreased_susceptibility_to1.28642304
68MP0001348_abnormal_lacrimal_gland1.27309165
69MP0001542_abnormal_bone_strength1.25880445
70MP0005501_abnormal_skin_physiology1.25064254
71MP0002089_abnormal_postnatal_growth/wei1.23934372
72MP0000604_amyloidosis1.23433063
73MP0000681_abnormal_thyroid_gland1.22384584
74MP0000733_abnormal_muscle_development1.19304087
75MP0000537_abnormal_urethra_morphology1.18974638
76MP0004858_abnormal_nervous_system1.18738178
77MP0002796_impaired_skin_barrier1.18704385
78MP0001485_abnormal_pinna_reflex1.17964472
79MP0003303_peritoneal_inflammation1.14403962
80MP0003172_abnormal_lysosome_physiology1.14284693
81MP0000759_abnormal_skeletal_muscle1.14190743
82MP0005275_abnormal_skin_tensile1.13528709
83MP0000920_abnormal_myelination1.13416571
84MP0005595_abnormal_vascular_smooth1.12428312
85MP0004036_abnormal_muscle_relaxation1.11723544
86MP0004215_abnormal_myocardial_fiber1.10688391
87MP0003646_muscle_fatigue1.10504061
88MP0005023_abnormal_wound_healing1.09753647
89MP0005503_abnormal_tendon_morphology1.09244323
90MP0000750_abnormal_muscle_regeneration1.09237656
91MP0002060_abnormal_skin_morphology1.07864631
92MP0005319_abnormal_enzyme/_coenzyme1.07684412
93MP0004087_abnormal_muscle_fiber1.07143452
94MP0010630_abnormal_cardiac_muscle1.05043995
95MP0003122_maternal_imprinting1.04683258
96MP0008775_abnormal_heart_ventricle1.04523554
97MP0009643_abnormal_urine_homeostasis1.04461792
98MP0008438_abnormal_cutaneous_collagen1.03809410
99MP0002972_abnormal_cardiac_muscle1.03488464
100MP0004947_skin_inflammation1.03210734
101MP0000767_abnormal_smooth_muscle1.02255880
102MP0003633_abnormal_nervous_system1.00909238
103MP0003879_abnormal_hair_cell1.00484844
104MP0000609_abnormal_liver_physiology0.99958358
105MP0005376_homeostasis/metabolism_phenot0.99296775
106MP0005084_abnormal_gallbladder_morpholo0.98804391
107MP0003705_abnormal_hypodermis_morpholog0.98742766
108MP0001986_abnormal_taste_sensitivity0.96364115
109MP0001853_heart_inflammation0.93360750
110MP0002896_abnormal_bone_mineralization0.93100755
111MP0005330_cardiomyopathy0.91283185
112MP0003950_abnormal_plasma_membrane0.90646146
113MP0005266_abnormal_metabolism0.90313287
114MP0000566_synostosis0.90205563
115MP0005508_abnormal_skeleton_morphology0.88068544
116MP0003634_abnormal_glial_cell0.87931868
117MP0000013_abnormal_adipose_tissue0.87671507
118MP0009780_abnormal_chondrocyte_physiolo0.87066547
119MP0001666_abnormal_nutrient_absorption0.85756648
120MP0002998_abnormal_bone_remodeling0.85627643
121MP0004142_abnormal_muscle_tone0.85588433
122MP0005636_abnormal_mineral_homeostasis0.84887242
123MP0005165_increased_susceptibility_to0.84674921
124MP0003075_altered_response_to0.84331226
125MP0003183_abnormal_peptide_metabolism0.83082852
126MP0002269_muscular_atrophy0.83021495
127MP0003195_calcinosis0.82692496
128MP0001544_abnormal_cardiovascular_syste0.82378633
129MP0005385_cardiovascular_system_phenoty0.82378633
130MP0001270_distended_abdomen0.81892554
131MP0000230_abnormal_systemic_arterial0.80160767
132MP0004859_abnormal_synaptic_plasticity0.80090314
133MP0004510_myositis0.80028388
134MP0000639_abnormal_adrenal_gland0.78604598
135MP0000747_muscle_weakness0.78126522
136MP0002971_abnormal_brown_adipose0.77893558
137MP0000534_abnormal_ureter_morphology0.77310319
138MP0004264_abnormal_extraembryonic_tissu0.77253215
139MP0009931_abnormal_skin_appearance0.77035812
140MP0005464_abnormal_platelet_physiology0.77021482
141MP0008874_decreased_physiological_sensi0.76969539
142MP0000467_abnormal_esophagus_morphology0.75823392
143MP0006035_abnormal_mitochondrial_morpho0.75592600
144MP0000462_abnormal_digestive_system0.74919428
145MP0000465_gastrointestinal_hemorrhage0.73138735
146MP0003942_abnormal_urinary_system0.71396890
147MP0005390_skeleton_phenotype0.71016989
148MP0009763_increased_sensitivity_to0.70311246
149MP0002132_abnormal_respiratory_system0.70208308
150MP0001346_abnormal_lacrimal_gland0.70200663
151MP0000598_abnormal_liver_morphology0.69363396
152MP0001533_abnormal_skeleton_physiology0.68295657
153MP0008469_abnormal_protein_level0.68233148
154MP0000343_altered_response_to0.67753193
155MP0002638_abnormal_pupillary_reflex0.66976180
156MP0005410_abnormal_fertilization0.66075941
157MP0000751_myopathy0.65548426
158MP0005379_endocrine/exocrine_gland_phen0.65543754
159MP0005551_abnormal_eye_electrophysiolog0.65441290
160MP0004782_abnormal_surfactant_physiolog0.64936899
161MP0009642_abnormal_blood_homeostasis0.64807244
162MP0003631_nervous_system_phenotype0.64569386
163MP0005621_abnormal_cell_physiology0.64486603
164MP0003868_abnormal_feces_composition0.64462828
165MP0003252_abnormal_bile_duct0.64414680
166MP0001915_intracranial_hemorrhage0.61074630
167MP0000477_abnormal_intestine_morphology0.60235415
168MP0003115_abnormal_respiratory_system0.59718701
169MP0009053_abnormal_anal_canal0.58894346
170MP0001614_abnormal_blood_vessel0.58497992
171MP0002970_abnormal_white_adipose0.58440076
172MP0002933_joint_inflammation0.57550860
173MP0002108_abnormal_muscle_morphology0.56363467

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)4.56625907
2Protrusio acetabuli (HP:0003179)4.06801462
3Abnormality of fatty-acid metabolism (HP:0004359)3.93730505
4Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.82740477
5Abnormality of aromatic amino acid family metabolism (HP:0004338)3.78848266
6Abnormality of secondary sexual hair (HP:0009888)3.61788229
7Abnormality of the axillary hair (HP:0100134)3.61788229
8Neuroendocrine neoplasm (HP:0100634)3.48362479
9Biconcave vertebral bodies (HP:0004586)3.31133418
10Abnormality of dicarboxylic acid metabolism (HP:0010995)3.28578915
11Dicarboxylic aciduria (HP:0003215)3.28578915
12Pheochromocytoma (HP:0002666)3.27354159
13Hepatic necrosis (HP:0002605)3.25326387
14Hyperacusis (HP:0010780)3.19385045
15Vertebral compression fractures (HP:0002953)3.18229755
16Hypoglycemic coma (HP:0001325)3.01156651
17Premature rupture of membranes (HP:0001788)2.96553317
18Ulnar bowing (HP:0003031)2.94869954
19Cerebral aneurysm (HP:0004944)2.91349255
20Abnormality of serine family amino acid metabolism (HP:0010894)2.89775840
21Abnormality of glycine metabolism (HP:0010895)2.89775840
22Hepatocellular necrosis (HP:0001404)2.88511478
23Obstructive sleep apnea (HP:0002870)2.79720763
24Ketosis (HP:0001946)2.76784996
25Increased variability in muscle fiber diameter (HP:0003557)2.75610096
26Hyperglycinuria (HP:0003108)2.74559048
27Abnormal gallbladder physiology (HP:0012438)2.72686497
28Cholecystitis (HP:0001082)2.72686497
29Thin bony cortex (HP:0002753)2.70587514
30Ketoacidosis (HP:0001993)2.68104001
31Abnormal mitochondria in muscle tissue (HP:0008316)2.67942412
32Hemorrhage of the eye (HP:0011885)2.67700061
33Hyperlipoproteinemia (HP:0010980)2.65898316
34Distal upper limb amyotrophy (HP:0007149)2.64825989
35Upper limb amyotrophy (HP:0009129)2.64825989
36Increased serum pyruvate (HP:0003542)2.64523765
37Abnormality of glycolysis (HP:0004366)2.64523765
38Depressed nasal tip (HP:0000437)2.64204201
39Turricephaly (HP:0000262)2.63626273
40Generalized aminoaciduria (HP:0002909)2.58400335
41Acute necrotizing encephalopathy (HP:0006965)2.58199343
42Distal lower limb amyotrophy (HP:0008944)2.56917574
43Myopathic facies (HP:0002058)2.55216318
44Brittle hair (HP:0002299)2.52092834
45Intrahepatic cholestasis (HP:0001406)2.51888184
46Methylmalonic aciduria (HP:0012120)2.51618274
47Centrally nucleated skeletal muscle fibers (HP:0003687)2.51117875
48Increased connective tissue (HP:0009025)2.49975231
49Hyperammonemia (HP:0001987)2.49313339
50Cerebral hemorrhage (HP:0001342)2.48457217
51Epiphyseal stippling (HP:0010655)2.48387403
52Neurofibrillary tangles (HP:0002185)2.47881831
53Decreased activity of mitochondrial respiratory chain (HP:0008972)2.47527512
54Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.47527512
55Acute encephalopathy (HP:0006846)2.47180351
56Myoglobinuria (HP:0002913)2.46923709
57Distal lower limb muscle weakness (HP:0009053)2.45704036
58Stridor (HP:0010307)2.44412340
59Cervical subluxation (HP:0003308)2.42114185
60Hyperbilirubinemia (HP:0002904)2.41435281
61Progressive neurologic deterioration (HP:0002344)2.40939612
62Abnormality of skeletal muscle fiber size (HP:0012084)2.40733930
63Achilles tendon contracture (HP:0001771)2.39538490
64Neonatal hypoglycemia (HP:0001998)2.36769234
65Disproportionate tall stature (HP:0001519)2.35615088
66Xanthomatosis (HP:0000991)2.33051499
67Abnormality of the umbilical cord (HP:0010881)2.31907417
68Exercise-induced myalgia (HP:0003738)2.31568616
69Shallow orbits (HP:0000586)2.30356552
70Abnormality of nail color (HP:0100643)2.30296178
71Mitochondrial inheritance (HP:0001427)2.30048394
72Hyperglycinemia (HP:0002154)2.29538033
73Abnormality of sulfur amino acid metabolism (HP:0004339)2.29132204
74Opisthotonus (HP:0002179)2.28386766
75Mitral regurgitation (HP:0001653)2.26527737
76Megaloblastic anemia (HP:0001889)2.26041885
77Hypoplastic left heart (HP:0004383)2.26035390
78Lactic acidosis (HP:0003128)2.25796172
79Increased neuronal autofluorescent lipopigment (HP:0002074)2.25666849
80Fragile skin (HP:0001030)2.24908288
81Abnormality of the Achilles tendon (HP:0005109)2.24174769
82Chronic otitis media (HP:0000389)2.23358216
83Cerebral edema (HP:0002181)2.22801168
84Cholelithiasis (HP:0001081)2.21512543
85Neoplasm of the adrenal gland (HP:0100631)2.20565774
86Brushfield spots (HP:0001088)2.20337130
87Spinal rigidity (HP:0003306)2.19083451
88Hypobetalipoproteinemia (HP:0003563)2.18939264
89Pancreatic islet-cell hyperplasia (HP:0004510)2.18933529
90Broad face (HP:0000283)2.18782611
91Mildly elevated creatine phosphokinase (HP:0008180)2.18332737
92Ragged-red muscle fibers (HP:0003200)2.16335318
93Abnormality of endocrine pancreas physiology (HP:0012093)2.16103457
94Abnormality of the pancreatic islet cells (HP:0006476)2.16103457
95Mucopolysacchariduria (HP:0008155)2.15864588
96Urinary glycosaminoglycan excretion (HP:0003541)2.15864588
97Exercise-induced muscle cramps (HP:0003710)2.15101028
98Abnormal gallbladder morphology (HP:0012437)2.13572666
99Blue sclerae (HP:0000592)2.13306551
100Increased CSF lactate (HP:0002490)2.13276975
101CNS demyelination (HP:0007305)2.13114311
102Late onset (HP:0003584)2.12874696
103Insomnia (HP:0100785)2.10516971
104Lethargy (HP:0001254)2.09896227
105Abnormality of methionine metabolism (HP:0010901)2.09042007
106Respiratory failure (HP:0002878)2.07747953
107Methylmalonic acidemia (HP:0002912)2.07526966
108Asymmetric septal hypertrophy (HP:0001670)2.05988577
109Cerebral inclusion bodies (HP:0100314)2.05548105
110Abnormality of polysaccharide metabolism (HP:0011012)2.05419155
111Abnormality of glycosaminoglycan metabolism (HP:0004371)2.05419155
112Abnormality of mucopolysaccharide metabolism (HP:0011020)2.05419155
113Vascular tortuosity (HP:0004948)2.03425640
114Aneurysm (HP:0002617)2.03414434
115Flat acetabular roof (HP:0003180)2.03268806
116Bladder diverticulum (HP:0000015)2.01205081
117Annular pancreas (HP:0001734)2.00909679
118Arterial tortuosity (HP:0005116)2.00274436
119Generalized amyotrophy (HP:0003700)2.00163061
120Enlarged kidneys (HP:0000105)1.97708812
121Hypolipoproteinemia (HP:0010981)1.97481682
122Hyperparathyroidism (HP:0000843)1.97449154
123Atelectasis (HP:0100750)1.95452952
124Abnormality of the thoracic spine (HP:0100711)1.94211977
125Hand muscle atrophy (HP:0009130)1.94139382
126Steatorrhea (HP:0002570)1.93399248
127Joint stiffness (HP:0001387)1.92895588
128Metabolic acidosis (HP:0001942)1.92458662
129Absent hair (HP:0002298)1.92094489
130Easy fatigability (HP:0003388)1.91766978
131Increased serum lactate (HP:0002151)1.91472791
132Lymphangioma (HP:0100764)1.91073199
133Fat malabsorption (HP:0002630)1.90309030
134Cerebral palsy (HP:0100021)1.90270382
135Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.90019748
136Hypoglycemic seizures (HP:0002173)1.89453313
137Aortic aneurysm (HP:0004942)1.88790032
138Hypoalphalipoproteinemia (HP:0003233)1.88618864
139Truncus arteriosus (HP:0001660)1.88591101
140Premature skin wrinkling (HP:0100678)1.87812147
141Increased cerebral lipofuscin (HP:0011813)1.87291995
142Broad distal phalanx of finger (HP:0009836)1.86971300
143Atrophic scars (HP:0001075)1.85978081
144Genu recurvatum (HP:0002816)1.85847906
145Cellulitis (HP:0100658)1.85022218
146Palpitations (HP:0001962)1.84843058
147Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84626272
148Sensorimotor neuropathy (HP:0007141)1.84507633
149Gout (HP:0001997)1.84003045
150Urticaria (HP:0001025)1.83950037
151Hyperthyroidism (HP:0000836)1.83642040
152Deep venous thrombosis (HP:0002625)1.83536950
153Increased muscle lipid content (HP:0009058)1.83106169
154Polygenic inheritance (HP:0010982)1.82428806
155Wormian bones (HP:0002645)1.81848980
156Progressive macrocephaly (HP:0004481)1.81001496
157Bulbar palsy (HP:0001283)1.79689197
158Aplasia involving bones of the upper limbs (HP:0009823)1.79581866
159Aplasia of the phalanges of the hand (HP:0009802)1.79581866
160Aplasia involving bones of the extremities (HP:0009825)1.79581866
161Dilatation of the ascending aorta (HP:0005111)1.79563008
162Reduced antithrombin III activity (HP:0001976)1.79185925
163Long palpebral fissure (HP:0000637)1.78647507
164Testicular atrophy (HP:0000029)1.78458316
165Dysostosis multiplex (HP:0000943)1.77633567
166Abnormality of serum amino acid levels (HP:0003112)1.77536560
167Axonal loss (HP:0003447)1.77415124
168Systemic lupus erythematosus (HP:0002725)1.76837709
169Abnormality of the gallbladder (HP:0005264)1.76346563
170Supranuclear gaze palsy (HP:0000605)1.74083857
171Thin ribs (HP:0000883)1.73245931
172Lower limb amyotrophy (HP:0007210)1.72236205
173Hypercortisolism (HP:0001578)1.71833980
174Ankle clonus (HP:0011448)1.71726341
175Broad metatarsal (HP:0001783)1.71549921
176Emphysema (HP:0002097)1.71201920
177J-shaped sella turcica (HP:0002680)1.70466211
178Abnormality of complement system (HP:0005339)1.70240053
179Hyperextensible skin (HP:0000974)1.69773502
180Hypertensive crisis (HP:0100735)1.68846909
181Short nail (HP:0001799)1.68725408
182Congenital glaucoma (HP:0001087)1.66787016
183Nuclear cataract (HP:0100018)1.66436349
184Pointed chin (HP:0000307)1.64802696
185Type 1 muscle fiber predominance (HP:0003803)1.64794997
186Advanced eruption of teeth (HP:0006288)1.64094153
187Difficulty climbing stairs (HP:0003551)1.63471681
188Metaphyseal cupping (HP:0003021)1.63248834
189Colitis (HP:0002583)1.62698170
190Polycythemia (HP:0001901)1.62634117
191Eczematoid dermatitis (HP:0000976)1.62432998
192Reticulocytosis (HP:0001923)1.61594498
193Neuronal loss in central nervous system (HP:0002529)1.61199496

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MUSK8.42243832
2BCKDK4.33432372
3SMG13.04938534
4TESK22.89550517
5PDK22.78005562
6TRIB32.72970834
7ERN12.72213958
8EEF2K2.52985083
9RIPK12.48842701
10ICK2.46648479
11STK162.35936629
12PDK42.23904611
13PDK32.23904611
14CCNB12.10359362
15MYLK2.09447432
16LMTK21.94479185
17EPHA21.86861544
18TIE11.76855522
19FLT31.75270687
20PIM21.67738243
21EIF2AK31.63779598
22PHKG21.51582439
23PHKG11.51582439
24CDK191.45144605
25NTRK11.43480622
26MAP3K111.43089307
27PDGFRA1.42134344
28KIT1.38686385
29CDK121.35033939
30MAP3K131.33927922
31MARK21.33665210
32KSR21.32667979
33MAP3K101.30906421
34ARAF1.30238625
35PRKD21.28940069
36SIK11.28599094
37LIMK11.25813304
38CLK11.25139628
39TNIK1.24535892
40PTK61.22308162
41NME21.19237229
42ZAP701.16762134
43TAOK21.16439182
44CDK81.12836762
45MAP4K11.07203738
46CDC42BPA1.04601512
47MAP3K31.04261257
48PTK21.03727926
49MAP3K11.03670007
50CSF1R1.00921294
51BMPR1B1.00531349
52PAK41.00161068
53TESK10.99375594
54EIF2AK10.95356021
55MTOR0.95329993
56RPS6KA20.93819242
57ILK0.89744754
58MAP2K30.89501722
59MST1R0.89049863
60PASK0.88096733
61BTK0.87358581
62FGFR20.85306927
63WEE10.84622056
64KDR0.82408679
65BMX0.82062683
66EPHB20.81143971
67TYRO30.78079937
68LRRK20.77966761
69DDR20.75499319
70TAOK10.75493851
71TYK20.74988857
72MAPK120.74066151
73MAP2K70.73475910
74RIPK40.73223007
75HIPK20.71522701
76PRPF4B0.71506556
77DYRK1B0.71352718
78BRAF0.70332723
79RET0.69831919
80CAMKK10.67750090
81MAP3K70.66867102
82NEK60.65909697
83MAP3K60.63956745
84TEC0.63867788
85MAPK70.62599406
86CAMK1D0.62319991
87TNK20.62314664
88SIK20.61260456
89SGK4940.61255019
90SGK2230.61255019
91IRAK30.60529727
92PTK2B0.59125537
93CAMK2G0.58630232
94EPHB10.58468640
95OXSR10.58450066
96MET0.58405404
97PDK10.55010815
98PIK3CG0.53963369
99FGFR40.52648408
100LATS20.52539043
101TBK10.52359276
102PRKACB0.52203101
103CAMK2D0.51692449
104PINK10.50871893
105DMPK0.49683172
106CAMK10.49032767
107MOS0.48990876
108DAPK30.48101949
109MAP2K60.46441093
110VRK10.46412078
111MAP2K20.46065095
112SYK0.45338350
113PRKCH0.45303496
114AKT20.45236924
115MAP3K80.44675579
116NEK10.43557022
117MAPKAPK30.43089050
118CDK150.42644299
119SGK20.42457679
120PRKG20.42160115
121PRKD10.41949491
122BUB10.41886876
123IRAK20.41689841
124MST40.41567627
125MAP3K90.40857592
126CDK180.40171109
127IRAK40.39306251
128MAP3K20.39221284
129MAPK110.39058298
130CDK40.39050099
131CDK11A0.37760090
132LYN0.37673611
133MAPK40.37534624
134RPS6KL10.36768370
135RPS6KC10.36768370
136STK380.36310918
137PAK20.35673000
138MAPKAPK50.35010254
139LATS10.34733363
140RPS6KA60.34700732
141BRSK20.34548516
142MAP3K120.34479936
143CDK140.33723239
144TTN0.33336204
145MAP2K40.33104364
146SCYL20.33054529
147ROCK20.32931636
148PAK60.32375662
149INSRR0.31816851
150ITK0.31428071
151CAMKK20.30779253
152PDPK10.30678456
153PRKD30.30327006
154IGF1R0.29836691
155PKN20.29676151
156CDK70.29311210
157BLK0.29031817
158NEK90.28765946
159SGK30.28629561
160MAPK150.28554536
161STK390.28486202
162TSSK60.28156414
163GRK60.27442129
164NTRK20.26357463

Predicted pathways (KEGG)

RankGene SetZ-score
1Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.51150185
2Fatty acid degradation_Homo sapiens_hsa000713.25339158
3Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.18212791
4Fatty acid elongation_Homo sapiens_hsa000623.03432764
5Fatty acid metabolism_Homo sapiens_hsa012122.91141762
6Propanoate metabolism_Homo sapiens_hsa006402.50951639
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.39706015
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.39345462
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.38028613
10Protein export_Homo sapiens_hsa030602.25190083
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.22203353
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.22184543
13Fatty acid biosynthesis_Homo sapiens_hsa000612.20203550
14Folate biosynthesis_Homo sapiens_hsa007902.12410731
15Pyruvate metabolism_Homo sapiens_hsa006202.11687015
16Carbon metabolism_Homo sapiens_hsa012002.04949288
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.01618041
18Peroxisome_Homo sapiens_hsa041461.98275136
19Notch signaling pathway_Homo sapiens_hsa043301.96353468
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95832903
21Steroid biosynthesis_Homo sapiens_hsa001001.89113691
22Biosynthesis of amino acids_Homo sapiens_hsa012301.85268898
23Pentose phosphate pathway_Homo sapiens_hsa000301.82442064
24Chronic myeloid leukemia_Homo sapiens_hsa052201.76121768
25Butanoate metabolism_Homo sapiens_hsa006501.70028261
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.68679951
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.67533035
28Acute myeloid leukemia_Homo sapiens_hsa052211.64200202
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63693970
30VEGF signaling pathway_Homo sapiens_hsa043701.62939416
31Sulfur metabolism_Homo sapiens_hsa009201.56767817
32PPAR signaling pathway_Homo sapiens_hsa033201.56456267
33Prion diseases_Homo sapiens_hsa050201.53829903
34Non-small cell lung cancer_Homo sapiens_hsa052231.53401337
35Central carbon metabolism in cancer_Homo sapiens_hsa052301.50824604
36Bladder cancer_Homo sapiens_hsa052191.49884375
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.45531844
38Tryptophan metabolism_Homo sapiens_hsa003801.43931983
39Oxidative phosphorylation_Homo sapiens_hsa001901.43434854
40Nitrogen metabolism_Homo sapiens_hsa009101.40371920
41Arginine and proline metabolism_Homo sapiens_hsa003301.37249363
42Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.36422954
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33248775
44Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.31075494
45Pancreatic cancer_Homo sapiens_hsa052121.30056422
46Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30008475
47N-Glycan biosynthesis_Homo sapiens_hsa005101.29944249
48Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.29479650
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.28897107
50Glutathione metabolism_Homo sapiens_hsa004801.28879847
51Parkinsons disease_Homo sapiens_hsa050121.27705683
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24019302
53Insulin signaling pathway_Homo sapiens_hsa049101.23073407
54Neurotrophin signaling pathway_Homo sapiens_hsa047221.21243694
55Endometrial cancer_Homo sapiens_hsa052131.20518289
56Fructose and mannose metabolism_Homo sapiens_hsa000511.20328553
57mTOR signaling pathway_Homo sapiens_hsa041501.16424763
58Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14576308
59Glioma_Homo sapiens_hsa052141.13934298
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.13537681
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.12498178
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.12240398
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.12051332
64Focal adhesion_Homo sapiens_hsa045101.10761844
65DNA replication_Homo sapiens_hsa030301.09967269
66Histidine metabolism_Homo sapiens_hsa003401.09749443
67Proteasome_Homo sapiens_hsa030501.08758955
68Steroid hormone biosynthesis_Homo sapiens_hsa001401.07961751
69AMPK signaling pathway_Homo sapiens_hsa041521.05978649
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.05500769
71Phospholipase D signaling pathway_Homo sapiens_hsa040721.04907100
72Galactose metabolism_Homo sapiens_hsa000521.04284813
73Thyroid cancer_Homo sapiens_hsa052161.03754304
74B cell receptor signaling pathway_Homo sapiens_hsa046621.01367733
75beta-Alanine metabolism_Homo sapiens_hsa004101.01077187
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.99698825
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96756694
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95930155
79Metabolic pathways_Homo sapiens_hsa011000.95618227
80Phenylalanine metabolism_Homo sapiens_hsa003600.94888646
81ECM-receptor interaction_Homo sapiens_hsa045120.94702003
82Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94206327
83Chemical carcinogenesis_Homo sapiens_hsa052040.92723518
84GnRH signaling pathway_Homo sapiens_hsa049120.92319090
85Renal cell carcinoma_Homo sapiens_hsa052110.91282434
86Amoebiasis_Homo sapiens_hsa051460.90630262
87Sulfur relay system_Homo sapiens_hsa041220.90510088
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.90269458
89ErbB signaling pathway_Homo sapiens_hsa040120.89769909
90Insulin resistance_Homo sapiens_hsa049310.88890123
91Arginine biosynthesis_Homo sapiens_hsa002200.88502267
92Complement and coagulation cascades_Homo sapiens_hsa046100.88428907
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86400328
94Tyrosine metabolism_Homo sapiens_hsa003500.85385284
95Starch and sucrose metabolism_Homo sapiens_hsa005000.83624871
96Inositol phosphate metabolism_Homo sapiens_hsa005620.82725592
97Selenocompound metabolism_Homo sapiens_hsa004500.82287647
98Lysosome_Homo sapiens_hsa041420.81433153
99Hepatitis C_Homo sapiens_hsa051600.80980822
100Endocytosis_Homo sapiens_hsa041440.80823936
101Small cell lung cancer_Homo sapiens_hsa052220.80466790
102ABC transporters_Homo sapiens_hsa020100.80186897
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79625189
104Proteoglycans in cancer_Homo sapiens_hsa052050.77458608
105Vitamin digestion and absorption_Homo sapiens_hsa049770.76789522
106Choline metabolism in cancer_Homo sapiens_hsa052310.76541860
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76245264
108Estrogen signaling pathway_Homo sapiens_hsa049150.70890768
109Alzheimers disease_Homo sapiens_hsa050100.70536705
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.70119529
111Dilated cardiomyopathy_Homo sapiens_hsa054140.68361127
112Osteoclast differentiation_Homo sapiens_hsa043800.66800941
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66119313
114Circadian rhythm_Homo sapiens_hsa047100.65712608
115Other glycan degradation_Homo sapiens_hsa005110.65466564
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65136342
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65126510
118Long-term potentiation_Homo sapiens_hsa047200.63913737
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62399602
120Prolactin signaling pathway_Homo sapiens_hsa049170.60820303
121Melanogenesis_Homo sapiens_hsa049160.59452993
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58959338
123Colorectal cancer_Homo sapiens_hsa052100.57824844
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56021918
125Apoptosis_Homo sapiens_hsa042100.54239278
126Glycerolipid metabolism_Homo sapiens_hsa005610.53873296
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52434950
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52433410
129Toxoplasmosis_Homo sapiens_hsa051450.51646632
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.51486271
131Vitamin B6 metabolism_Homo sapiens_hsa007500.51027211
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50542361
133Glucagon signaling pathway_Homo sapiens_hsa049220.50347429
134Pyrimidine metabolism_Homo sapiens_hsa002400.50183989
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50043099
136Lysine degradation_Homo sapiens_hsa003100.49843493
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49301455
138Prostate cancer_Homo sapiens_hsa052150.49133746
139Retinol metabolism_Homo sapiens_hsa008300.48093593
140Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47533291
141Huntingtons disease_Homo sapiens_hsa050160.47458722
142HIF-1 signaling pathway_Homo sapiens_hsa040660.47425088
143One carbon pool by folate_Homo sapiens_hsa006700.47406914
144Cyanoamino acid metabolism_Homo sapiens_hsa004600.46265795
145Rap1 signaling pathway_Homo sapiens_hsa040150.46022694
146Bile secretion_Homo sapiens_hsa049760.46006783
147Hepatitis B_Homo sapiens_hsa051610.45827149
148Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45668099
149Vibrio cholerae infection_Homo sapiens_hsa051100.44925930
150Adipocytokine signaling pathway_Homo sapiens_hsa049200.44885694
151HTLV-I infection_Homo sapiens_hsa051660.43744122
152Glycosaminoglycan degradation_Homo sapiens_hsa005310.42619993
153Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40293123
154Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40103350
155Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39660259
156Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38306336
157Caffeine metabolism_Homo sapiens_hsa002320.36943041
158Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.36071678
159Mismatch repair_Homo sapiens_hsa034300.35328385
160Cardiac muscle contraction_Homo sapiens_hsa042600.35211869
161Purine metabolism_Homo sapiens_hsa002300.32497072
162Sphingolipid metabolism_Homo sapiens_hsa006000.31189803
163Nucleotide excision repair_Homo sapiens_hsa034200.29559373
164Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.27218755
165Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.24045306
166Maturity onset diabetes of the young_Homo sapiens_hsa049500.23329254
167Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16418898
168Base excision repair_Homo sapiens_hsa034100.14801154
169Collecting duct acid secretion_Homo sapiens_hsa049660.13509985

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