TMEM130

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.17428349
2vocalization behavior (GO:0071625)5.74658949
3synaptic vesicle maturation (GO:0016188)5.51110458
4neuron cell-cell adhesion (GO:0007158)5.47216768
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.41306731
6synaptic vesicle exocytosis (GO:0016079)5.27518092
7regulation of synaptic vesicle exocytosis (GO:2000300)5.06521525
8locomotory exploration behavior (GO:0035641)4.98420138
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.85399890
10neurotransmitter secretion (GO:0007269)4.83786305
11glutamate secretion (GO:0014047)4.76758991
12regulation of glutamate receptor signaling pathway (GO:1900449)4.74543076
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72207248
14gamma-aminobutyric acid transport (GO:0015812)4.66660562
15protein localization to synapse (GO:0035418)4.51310368
16regulation of synaptic vesicle transport (GO:1902803)4.51259355
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.43084427
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.35981997
19positive regulation of synaptic transmission, GABAergic (GO:0032230)4.22512447
20layer formation in cerebral cortex (GO:0021819)4.22107137
21exploration behavior (GO:0035640)4.21305140
22proline transport (GO:0015824)4.16683350
23neurotransmitter transport (GO:0006836)4.07081015
24neuron recognition (GO:0008038)4.04031705
25positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.94847033
26regulation of neuronal synaptic plasticity (GO:0048168)3.93788880
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92346278
28synaptic vesicle docking involved in exocytosis (GO:0016081)3.92324337
29cerebellar granule cell differentiation (GO:0021707)3.90243451
30neuronal action potential propagation (GO:0019227)3.84585276
31neuromuscular process controlling posture (GO:0050884)3.84516679
32L-amino acid import (GO:0043092)3.83934680
33regulation of voltage-gated calcium channel activity (GO:1901385)3.83746113
34glutamate receptor signaling pathway (GO:0007215)3.81269119
35neurotransmitter-gated ion channel clustering (GO:0072578)3.80172505
36regulation of synapse structural plasticity (GO:0051823)3.79860359
37regulation of neurotransmitter levels (GO:0001505)3.78336118
38neuron-neuron synaptic transmission (GO:0007270)3.76484300
39synaptic transmission, glutamatergic (GO:0035249)3.75021278
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.74676004
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71946000
42transmission of nerve impulse (GO:0019226)3.68374342
43positive regulation of dendritic spine development (GO:0060999)3.68187493
44postsynaptic membrane organization (GO:0001941)3.67583221
45activation of protein kinase A activity (GO:0034199)3.67175653
46dendritic spine morphogenesis (GO:0060997)3.65351140
47axon ensheathment in central nervous system (GO:0032291)3.63681532
48central nervous system myelination (GO:0022010)3.63681532
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.60330701
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.56913091
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.53305879
52long-term memory (GO:0007616)3.50243847
53regulation of dendritic spine morphogenesis (GO:0061001)3.49097633
54positive regulation of neurotransmitter transport (GO:0051590)3.46062299
55potassium ion import (GO:0010107)3.45563359
56cellular potassium ion homeostasis (GO:0030007)3.45555210
57response to pheromone (GO:0019236)3.45380816
58axonal fasciculation (GO:0007413)3.45168348
59amino acid import (GO:0043090)3.41042655
60neuromuscular synaptic transmission (GO:0007274)3.40678249
61positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.40559601
62potassium ion homeostasis (GO:0055075)3.40178655
63positive regulation of dendritic spine morphogenesis (GO:0061003)3.38662344
64cerebellar Purkinje cell differentiation (GO:0021702)3.38356844
65positive regulation of neurotransmitter secretion (GO:0001956)3.34489555
66synaptic vesicle endocytosis (GO:0048488)3.33895544
67response to auditory stimulus (GO:0010996)3.31452575
68regulation of synaptic transmission, GABAergic (GO:0032228)3.30469976
69cerebellar Purkinje cell layer development (GO:0021680)3.30020499
70synaptic vesicle transport (GO:0048489)3.29490743
71establishment of synaptic vesicle localization (GO:0097480)3.29490743
72synapse assembly (GO:0007416)3.28109359
73startle response (GO:0001964)3.28009019
74intraspecies interaction between organisms (GO:0051703)3.27453056
75social behavior (GO:0035176)3.27453056
76mating behavior (GO:0007617)3.26752846
77auditory behavior (GO:0031223)3.26664937
78negative regulation of dendrite morphogenesis (GO:0050774)3.24768116
79regulation of dendritic spine development (GO:0060998)3.24162323
80regulation of vesicle fusion (GO:0031338)3.24052329
81positive regulation of synapse assembly (GO:0051965)3.23520330
82regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.23057819
83positive regulation of membrane potential (GO:0045838)3.22356538
84presynaptic membrane assembly (GO:0097105)3.20612556
85glycine transport (GO:0015816)3.20040688
86regulation of excitatory postsynaptic membrane potential (GO:0060079)3.19860552
87dendritic spine organization (GO:0097061)3.19743268
88prepulse inhibition (GO:0060134)3.18658955
89regulation of neurotransmitter secretion (GO:0046928)3.18006750
90regulation of synapse maturation (GO:0090128)3.17186547
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.16451450
92regulation of postsynaptic membrane potential (GO:0060078)3.16420589
93regulation of synaptic transmission, glutamatergic (GO:0051966)3.15908729
94positive regulation of synapse maturation (GO:0090129)3.15709191
95vesicle transport along microtubule (GO:0047496)3.14154230
96response to histamine (GO:0034776)3.13673265
97membrane hyperpolarization (GO:0060081)3.10951831
98regulation of synaptic transmission (GO:0050804)3.10739496
99serotonin metabolic process (GO:0042428)3.10331903
100regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09605124
101establishment of mitochondrion localization (GO:0051654)3.09295489
102sodium ion export (GO:0071436)3.09013365
103dendrite morphogenesis (GO:0048813)3.08467396
104neuronal ion channel clustering (GO:0045161)3.08050801
105neurotransmitter uptake (GO:0001504)3.06419156
106adult walking behavior (GO:0007628)3.05932250
107cellular sodium ion homeostasis (GO:0006883)3.05007002
108membrane depolarization during action potential (GO:0086010)3.04330813
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.03521357
110regulation of neurotransmitter transport (GO:0051588)3.02655932
111regulation of glutamate secretion (GO:0014048)3.00786535
112synaptic transmission (GO:0007268)3.00432017
113striatum development (GO:0021756)2.99519429
114acidic amino acid transport (GO:0015800)2.99285268
115presynaptic membrane organization (GO:0097090)2.99071175
116negative regulation of microtubule polymerization (GO:0031115)2.98872039
117long-term synaptic potentiation (GO:0060291)2.98578137
118behavioral fear response (GO:0001662)2.98300790
119behavioral defense response (GO:0002209)2.98300790
120detection of calcium ion (GO:0005513)2.97918324
121regulation of synaptic plasticity (GO:0048167)2.97789078
122regulation of female receptivity (GO:0045924)2.97115322
123positive regulation of potassium ion transmembrane transport (GO:1901381)2.96556099
124acid secretion (GO:0046717)2.96138269
125learning (GO:0007612)2.94448454
126cell migration in hindbrain (GO:0021535)2.94071360
127positive regulation of synaptic transmission (GO:0050806)2.93880477
128cell communication by electrical coupling (GO:0010644)2.93024920
129regulation of cAMP-dependent protein kinase activity (GO:2000479)2.92572313
130synapse organization (GO:0050808)2.92429445
131membrane depolarization (GO:0051899)2.92059300
132neuromuscular process controlling balance (GO:0050885)2.91329493

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.50983566
2GBX2_23144817_ChIP-Seq_PC3_Human3.67922370
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.12056051
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00219765
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96936170
6REST_21632747_ChIP-Seq_MESCs_Mouse2.88505186
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76650808
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.75271419
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57971868
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57971868
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.56416142
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.55267269
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54539671
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.53645919
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.51220639
16GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.47384234
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46487413
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44401437
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.39694606
20TAF15_26573619_Chip-Seq_HEK293_Human2.33892792
21DROSHA_22980978_ChIP-Seq_HELA_Human2.30336574
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28671300
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.26673889
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.21928736
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.21139883
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11270572
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.04279976
28CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02249819
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86725662
30CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80187962
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77247938
32AR_21572438_ChIP-Seq_LNCaP_Human1.74408457
33ZNF274_21170338_ChIP-Seq_K562_Hela1.70126443
34IGF1R_20145208_ChIP-Seq_DFB_Human1.69561316
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.64813681
36SMAD4_21799915_ChIP-Seq_A2780_Human1.64668426
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.59012304
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58985559
39SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48469234
40ERG_21242973_ChIP-ChIP_JURKAT_Human1.48306601
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47513061
42CBX2_27304074_Chip-Seq_ESCs_Mouse1.44493682
43P300_19829295_ChIP-Seq_ESCs_Human1.44386992
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39026066
45RNF2_27304074_Chip-Seq_NSC_Mouse1.38963049
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.34487843
47PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32170615
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.32020889
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30139664
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.29575608
51RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.29076639
52THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.27643990
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26896737
54NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26674584
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.26631545
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24858680
57AR_25329375_ChIP-Seq_VCAP_Human1.24769879
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21107656
59DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20743696
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20078794
61STAT3_23295773_ChIP-Seq_U87_Human1.17307412
62AR_19668381_ChIP-Seq_PC3_Human1.14569298
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.13944936
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13628279
65TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12706552
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.11614294
67POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08614844
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.07971450
69CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06897389
70MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04917419
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.02310979
72TCF4_23295773_ChIP-Seq_U87_Human1.02162517
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01658248
74RUNX2_22187159_ChIP-Seq_PCA_Human1.01169255
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00843580
76ARNT_22903824_ChIP-Seq_MCF-7_Human0.98429678
77CTCF_27219007_Chip-Seq_Bcells_Human0.97211350
78ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96572765
79YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96519352
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95940107
81SMAD3_21741376_ChIP-Seq_ESCs_Human0.95525974
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.95509365
83RING1B_27294783_Chip-Seq_NPCs_Mouse0.95057333
84AHR_22903824_ChIP-Seq_MCF-7_Human0.94236019
85WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93617791
86TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93608629
87TET1_21490601_ChIP-Seq_MESCs_Mouse0.93551433
88* ER_23166858_ChIP-Seq_MCF-7_Human0.93373126
89* JUN_21703547_ChIP-Seq_K562_Human0.92479156
90OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92402514
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92086019
92NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91760529
93SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91668072
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90985596
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89627798
96LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88784158
97* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88145536
98PRDM14_20953172_ChIP-Seq_ESCs_Human0.86942358
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.86438811
100FUS_26573619_Chip-Seq_HEK293_Human0.86370112
101PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.85053262
102KDM2B_26808549_Chip-Seq_REH_Human0.84556243
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.84293176
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.83571551
105VDR_22108803_ChIP-Seq_LS180_Human0.83136049
106POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.81398971
107TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81398971
108GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81258323
109CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80653455
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79584627
111* NANOG_18555785_Chip-Seq_ESCs_Mouse0.79326897
112TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.79188634
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.77968607
114SOX9_26525672_Chip-Seq_HEART_Mouse0.77946170

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.17055079
2MP0003880_abnormal_central_pattern4.82773596
3MP0003635_abnormal_synaptic_transmissio3.86449003
4MP0009745_abnormal_behavioral_response3.29056238
5MP0005423_abnormal_somatic_nervous3.21200221
6MP0009046_muscle_twitch3.19678476
7MP0002064_seizures3.13873060
8MP0002063_abnormal_learning/memory/cond3.05455801
9MP0004270_analgesia3.03564780
10MP0001968_abnormal_touch/_nociception2.98259493
11MP0006276_abnormal_autonomic_nervous2.94790887
12MP0003122_maternal_imprinting2.93220701
13MP0002572_abnormal_emotion/affect_behav2.70168370
14MP0002734_abnormal_mechanical_nocicepti2.55817193
15MP0005645_abnormal_hypothalamus_physiol2.53327311
16MP0002272_abnormal_nervous_system2.51639869
17MP0001501_abnormal_sleep_pattern2.50084953
18MP0001486_abnormal_startle_reflex2.37433584
19MP0002736_abnormal_nociception_after2.33624449
20MP0002822_catalepsy2.30972654
21MP0001440_abnormal_grooming_behavior2.27493514
22MP0002735_abnormal_chemical_nociception2.25820031
23MP0002733_abnormal_thermal_nociception2.21364208
24MP0005646_abnormal_pituitary_gland2.17520124
25MP0001970_abnormal_pain_threshold2.07361500
26MP0001529_abnormal_vocalization2.03811608
27MP0002067_abnormal_sensory_capabilities1.96020511
28MP0003787_abnormal_imprinting1.91777906
29MP0002184_abnormal_innervation1.89441268
30MP0002557_abnormal_social/conspecific_i1.87430612
31MP0004924_abnormal_behavior1.80213030
32MP0005386_behavior/neurological_phenoty1.80213030
33MP0000778_abnormal_nervous_system1.78118482
34MP0009780_abnormal_chondrocyte_physiolo1.70385410
35MP0002909_abnormal_adrenal_gland1.70012376
36MP0003329_amyloid_beta_deposits1.68483898
37MP0001984_abnormal_olfaction1.67170315
38MP0004142_abnormal_muscle_tone1.66593272
39MP0004811_abnormal_neuron_physiology1.65531735
40MP0004858_abnormal_nervous_system1.64457217
41MP0001905_abnormal_dopamine_level1.59508071
42MP0008569_lethality_at_weaning1.58117469
43MP0000955_abnormal_spinal_cord1.50653393
44MP0001502_abnormal_circadian_rhythm1.40872835
45MP0002066_abnormal_motor_capabilities/c1.40698012
46MP0002882_abnormal_neuron_morphology1.37430293
47MP0003879_abnormal_hair_cell1.28321540
48MP0010386_abnormal_urinary_bladder1.27863887
49MP0003121_genomic_imprinting1.26752048
50MP0004885_abnormal_endolymph1.25496099
51MP0000751_myopathy1.21991671
52MP0004147_increased_porphyrin_level1.20548732
53MP0001188_hyperpigmentation1.15974305
54MP0002638_abnormal_pupillary_reflex1.15948861
55MP0001485_abnormal_pinna_reflex1.15680534
56MP0003633_abnormal_nervous_system1.10102304
57MP0000013_abnormal_adipose_tissue1.09985914
58MP0002152_abnormal_brain_morphology1.07235877
59MP0003123_paternal_imprinting1.01753865
60MP0002229_neurodegeneration1.01016150
61MP0001986_abnormal_taste_sensitivity1.00876453
62MP0008872_abnormal_physiological_respon1.00728087
63MP0002069_abnormal_eating/drinking_beha0.99913612
64MP0000569_abnormal_digit_pigmentation0.96991813
65MP0000631_abnormal_neuroendocrine_gland0.96789428
66MP0003631_nervous_system_phenotype0.95207110
67MP0003283_abnormal_digestive_organ0.94604419
68MP0008961_abnormal_basal_metabolism0.90385961
69MP0005535_abnormal_body_temperature0.89705606
70MP0005551_abnormal_eye_electrophysiolog0.89588187
71MP0002837_dystrophic_cardiac_calcinosis0.89176776
72MP0005499_abnormal_olfactory_system0.88264183
73MP0005394_taste/olfaction_phenotype0.88264183
74MP0004742_abnormal_vestibular_system0.88226173
75MP0003634_abnormal_glial_cell0.87845389
76MP0002876_abnormal_thyroid_physiology0.86432926
77MP0003690_abnormal_glial_cell0.85296476
78MP0002653_abnormal_ependyma_morphology0.81810997
79MP0004085_abnormal_heartbeat0.79801754
80MP0001177_atelectasis0.78697378
81MP0002752_abnormal_somatic_nervous0.77527523
82MP0004145_abnormal_muscle_electrophysio0.76903434
83MP0001963_abnormal_hearing_physiology0.75971918
84MP0001664_abnormal_digestion0.72652722
85MP0002102_abnormal_ear_morphology0.71766754
86MP0000026_abnormal_inner_ear0.71437979
87MP0004233_abnormal_muscle_weight0.70616209
88MP0008874_decreased_physiological_sensi0.70223277
89MP0006072_abnormal_retinal_apoptosis0.69847951
90MP0003632_abnormal_nervous_system0.69640514
91MP0005167_abnormal_blood-brain_barrier0.69181219
92MP0000604_amyloidosis0.68340860
93MP0001299_abnormal_eye_distance/0.66347544
94MP0000920_abnormal_myelination0.63876746
95MP0003183_abnormal_peptide_metabolism0.63536940
96MP0003137_abnormal_impulse_conducting0.63167902
97MP0001943_abnormal_respiration0.61365885
98MP0005379_endocrine/exocrine_gland_phen0.58886437
99MP0008877_abnormal_DNA_methylation0.57999832
100MP0001348_abnormal_lacrimal_gland0.56834013
101MP0002090_abnormal_vision0.55988973
102MP0004133_heterotaxia0.54818808
103MP0002082_postnatal_lethality0.54592038
104MP0010770_preweaning_lethality0.54592038
105MP0010769_abnormal_survival0.53059817
106MP0003861_abnormal_nervous_system0.52671197
107MP0003646_muscle_fatigue0.52261489
108MP0005253_abnormal_eye_physiology0.51855072
109MP0003956_abnormal_body_size0.51172507
110MP0004215_abnormal_myocardial_fiber0.50992899
111MP0010768_mortality/aging0.50603150
112MP0001346_abnormal_lacrimal_gland0.49009257
113MP0004043_abnormal_pH_regulation0.47347762

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.95601546
2Myokymia (HP:0002411)5.67510332
3Focal seizures (HP:0007359)5.37318898
4Visual hallucinations (HP:0002367)5.22546381
5Atonic seizures (HP:0010819)4.57990025
6Epileptic encephalopathy (HP:0200134)4.30928689
7Febrile seizures (HP:0002373)4.22262692
8Absence seizures (HP:0002121)4.19788598
9Polyphagia (HP:0002591)4.02414544
10Progressive cerebellar ataxia (HP:0002073)3.99350044
11Limb dystonia (HP:0002451)3.96193512
12Generalized tonic-clonic seizures (HP:0002069)3.90394080
13Abnormal eating behavior (HP:0100738)3.76940309
14Supranuclear gaze palsy (HP:0000605)3.76876607
15Failure to thrive in infancy (HP:0001531)3.76288384
16Dialeptic seizures (HP:0011146)3.72936123
17Ankle clonus (HP:0011448)3.57752050
18Mutism (HP:0002300)3.50765020
19Progressive inability to walk (HP:0002505)3.36634683
20Pheochromocytoma (HP:0002666)3.24270483
21Depression (HP:0000716)3.23418574
22Broad-based gait (HP:0002136)3.13634302
23Cerebral hypomyelination (HP:0006808)3.10923094
24Anxiety (HP:0000739)3.03383177
25Action tremor (HP:0002345)2.97010331
26Truncal ataxia (HP:0002078)2.87853745
27Neuroendocrine neoplasm (HP:0100634)2.86915917
28Poor eye contact (HP:0000817)2.83165445
29Excessive salivation (HP:0003781)2.81373988
30Drooling (HP:0002307)2.81373988
31Papilledema (HP:0001085)2.80160486
32Agitation (HP:0000713)2.79215014
33Hyperventilation (HP:0002883)2.79193692
34Postural instability (HP:0002172)2.78129670
35Impaired vibration sensation in the lower limbs (HP:0002166)2.77069039
36Impaired social interactions (HP:0000735)2.74326880
37Abnormal social behavior (HP:0012433)2.74326880
38Abnormal hair whorl (HP:0010721)2.73367003
39Delusions (HP:0000746)2.71788373
40Dysdiadochokinesis (HP:0002075)2.71261966
41Urinary bladder sphincter dysfunction (HP:0002839)2.69810184
42Annular pancreas (HP:0001734)2.60479271
43Spastic gait (HP:0002064)2.56870560
44Bradykinesia (HP:0002067)2.54832957
45Dysmetria (HP:0001310)2.52044602
46Neurofibrillary tangles (HP:0002185)2.51755305
47Urinary urgency (HP:0000012)2.49421718
48Torticollis (HP:0000473)2.49315628
49Poor suck (HP:0002033)2.47862919
50Abnormality of the corticospinal tract (HP:0002492)2.46435923
51Hypoventilation (HP:0002791)2.44534661
52Amblyopia (HP:0000646)2.43987231
53Epileptiform EEG discharges (HP:0011182)2.43209573
54Hemiparesis (HP:0001269)2.42183826
55EEG with generalized epileptiform discharges (HP:0011198)2.41381777
56Sleep apnea (HP:0010535)2.38510184
57Cerebral inclusion bodies (HP:0100314)2.35983430
58Gaze-evoked nystagmus (HP:0000640)2.34076468
59Degeneration of the lateral corticospinal tracts (HP:0002314)2.33256906
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.33256906
61Peripheral hypomyelination (HP:0007182)2.33201582
62Morphological abnormality of the pyramidal tract (HP:0002062)2.32360926
63Genetic anticipation (HP:0003743)2.31872767
64Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.31513764
65Hypsarrhythmia (HP:0002521)2.31332527
66Akinesia (HP:0002304)2.31296770
67Focal dystonia (HP:0004373)2.31186722
68Esotropia (HP:0000565)2.30312296
69Diplopia (HP:0000651)2.28362544
70Abnormality of binocular vision (HP:0011514)2.28362544
71Gait imbalance (HP:0002141)2.27684901
72Abnormality of the lower motor neuron (HP:0002366)2.26910637
73CNS hypomyelination (HP:0003429)2.25802932
74Fetal akinesia sequence (HP:0001989)2.25236346
75Psychosis (HP:0000709)2.24173534
76Specific learning disability (HP:0001328)2.22878149
77Inability to walk (HP:0002540)2.21448960
78Abnormality of the labia minora (HP:0012880)2.20449430
79Lower limb muscle weakness (HP:0007340)2.19194014
80Craniofacial dystonia (HP:0012179)2.17350173
81Oligomenorrhea (HP:0000876)2.14763822
82Hemiplegia (HP:0002301)2.14397083
83Amyotrophic lateral sclerosis (HP:0007354)2.14340811
84Ventricular fibrillation (HP:0001663)2.13085026
85Spastic tetraplegia (HP:0002510)2.11232494
86Insidious onset (HP:0003587)2.09900744
87Termporal pattern (HP:0011008)2.09900744
88Status epilepticus (HP:0002133)2.08493114
89Narrow nasal bridge (HP:0000446)2.07235670
90Tetraplegia (HP:0002445)2.06798969
91Impaired vibratory sensation (HP:0002495)2.06420467
92Absent speech (HP:0001344)2.03468807
93Scanning speech (HP:0002168)2.03332589
94Neuronal loss in central nervous system (HP:0002529)2.01958816
95Protruding tongue (HP:0010808)2.01670872
96Spastic tetraparesis (HP:0001285)2.01123505
97Ulnar claw (HP:0001178)2.00205808
98Generalized myoclonic seizures (HP:0002123)2.00051728
99Blue irides (HP:0000635)1.99535511
100Impaired smooth pursuit (HP:0007772)1.95725799
101Incomplete penetrance (HP:0003829)1.95011495
102Hyperthyroidism (HP:0000836)1.94747472
103Type II lissencephaly (HP:0007260)1.94350814
104Aplasia/Hypoplasia of the brainstem (HP:0007362)1.91281624
105Hypoplasia of the brainstem (HP:0002365)1.91281624
106Rigidity (HP:0002063)1.90686285
107Clonus (HP:0002169)1.89587486
108Intention tremor (HP:0002080)1.89040563
109Neoplasm of the peripheral nervous system (HP:0100007)1.88764410
110Choreoathetosis (HP:0001266)1.88541174
111Generalized hypotonia (HP:0001290)1.88369223
112Abnormality of salivation (HP:0100755)1.85917765
113Apathy (HP:0000741)1.85334766
114Abnormality of ocular smooth pursuit (HP:0000617)1.83830699
115Abnormal EKG (HP:0003115)1.83034822
116Lissencephaly (HP:0001339)1.82798566
117Impaired pain sensation (HP:0007328)1.82388779
118Abnormality of pain sensation (HP:0010832)1.82388779
119Obstructive sleep apnea (HP:0002870)1.81709659
120Split foot (HP:0001839)1.78699038
121Unsteady gait (HP:0002317)1.76436409
122Retinal dysplasia (HP:0007973)1.74568297
123Diminished motivation (HP:0000745)1.71288526
124Prolonged QT interval (HP:0001657)1.71279633
125Megalencephaly (HP:0001355)1.71181905
126Stereotypic behavior (HP:0000733)1.69573030
127Increased circulating renin level (HP:0000848)1.67043720

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.30446903
2MARK14.11379907
3MAP3K93.57352789
4MAP3K43.34579748
5MAP3K123.20255813
6MAP2K72.93298996
7NTRK22.89890390
8MINK12.85166413
9CASK2.59625547
10EPHA42.34659489
11MAP2K42.25437684
12PAK61.88742184
13NTRK11.75453162
14PNCK1.71342195
15MAPK131.65042470
16UHMK11.63209107
17GRK51.58036374
18DAPK21.56923870
19TNIK1.52044708
20CDK51.51661690
21PLK21.44848943
22SIK21.43062427
23PHKG11.41237191
24PHKG21.41237191
25CDK191.34838510
26KSR11.31291193
27KSR21.28082784
28SIK31.25547080
29PRKCG1.25341436
30ARAF1.20913331
31LATS21.19125228
32CAMKK11.15700221
33MAP4K21.14284097
34FES1.10379463
35DAPK11.10301541
36SGK2231.08574851
37SGK4941.08574851
38PRKD31.05129127
39WNK31.03952780
40CAMK2A1.02826626
41STK381.02745809
42CDK180.97949428
43CSNK1G20.96437965
44PRPF4B0.96122792
45BCR0.94259257
46PAK30.94167077
47TNK20.93667815
48SGK20.93128640
49CDK140.92831598
50LMTK20.92178787
51MAP3K110.91737225
52CDK150.91377585
53PRKCH0.88115135
54AKT30.87528173
55OXSR10.86206987
56TYRO30.86147784
57RIPK40.80573117
58CAMK2B0.79321685
59CDK11A0.78405583
60SGK30.70557029
61DYRK1A0.68759435
62CAMK40.68627141
63STK110.68162875
64GRK70.66529743
65RET0.66384732
66CAMK10.65549692
67NEK60.65291929
68MAP3K20.64426483
69ADRBK20.63836059
70PRKCE0.63252188
71FER0.62409989
72ALK0.61730091
73PINK10.60500443
74BRSK10.59933446
75ERBB30.59756682
76CSNK1G30.59616653
77MARK20.59432747
78FRK0.59247187
79SGK10.58400654
80MAPK120.57576884
81CAMKK20.56822098
82LIMK10.56624307
83CAMK2G0.56110773
84WNK40.55872895
85CAMK2D0.55240452
86SCYL20.54953930
87RPS6KA20.54603645
88NME10.52853099
89PDK10.52815937
90CAMK1G0.52338274
91BRAF0.50952340
92CDC42BPA0.50547000
93PRKCZ0.49574478
94MAP3K10.49038785
95MAP3K130.48965333
96ADRBK10.47520856
97RPS6KA30.47512925
98PKN10.45085057
99MAPKAPK50.43723106
100CSNK1A1L0.43503286
101DYRK20.43240787
102TSSK60.43027669
103PRKCA0.42982348
104MAPK100.42697960
105FGFR20.42604266
106DAPK30.41375709
107FYN0.41003583
108WNK10.39666651
109STK390.38794835
110BMPR20.38721744
111TAOK10.37147186
112ROCK20.37100935
113GRK10.36250307
114MAP2K60.35669465
115PRKCB0.35092575
116ROCK10.34753185
117PRKG10.34551823
118PDPK10.34438598
119CSNK1G10.33651388
120PRKACA0.33423373
121CSNK1A10.33267575
122CSNK1E0.32474184
123CSNK1D0.31353015

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.26057213
2Synaptic vesicle cycle_Homo sapiens_hsa047213.90909191
3GABAergic synapse_Homo sapiens_hsa047273.17097692
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.71181352
5Olfactory transduction_Homo sapiens_hsa047402.56588233
6Morphine addiction_Homo sapiens_hsa050322.56472098
7Circadian entrainment_Homo sapiens_hsa047132.46616304
8Glutamatergic synapse_Homo sapiens_hsa047242.34149757
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.31473572
10Collecting duct acid secretion_Homo sapiens_hsa049662.23439566
11Amphetamine addiction_Homo sapiens_hsa050312.22375762
12Dopaminergic synapse_Homo sapiens_hsa047282.17824943
13Long-term potentiation_Homo sapiens_hsa047202.16145452
14Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.01908194
15Insulin secretion_Homo sapiens_hsa049111.98689246
16Taste transduction_Homo sapiens_hsa047421.97337355
17Cocaine addiction_Homo sapiens_hsa050301.96632523
18Salivary secretion_Homo sapiens_hsa049701.89542234
19Serotonergic synapse_Homo sapiens_hsa047261.89475273
20Cholinergic synapse_Homo sapiens_hsa047251.76912630
21Gastric acid secretion_Homo sapiens_hsa049711.66712059
22Long-term depression_Homo sapiens_hsa047301.66089128
23Vibrio cholerae infection_Homo sapiens_hsa051101.57089930
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.54356160
25Renin secretion_Homo sapiens_hsa049241.50916436
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49512102
27Calcium signaling pathway_Homo sapiens_hsa040201.41551138
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.38104004
29Oxytocin signaling pathway_Homo sapiens_hsa049211.32906207
30Gap junction_Homo sapiens_hsa045401.29856711
31Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.26643764
32Cardiac muscle contraction_Homo sapiens_hsa042601.24919740
33GnRH signaling pathway_Homo sapiens_hsa049121.22881237
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.21859229
35Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17848495
36Axon guidance_Homo sapiens_hsa043601.15845288
37Oxidative phosphorylation_Homo sapiens_hsa001901.11902432
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.08760313
39Type II diabetes mellitus_Homo sapiens_hsa049301.06813122
40cAMP signaling pathway_Homo sapiens_hsa040241.06725085
41Estrogen signaling pathway_Homo sapiens_hsa049151.05380029
42Vitamin B6 metabolism_Homo sapiens_hsa007501.05348142
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03047775
44Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99763204
45Type I diabetes mellitus_Homo sapiens_hsa049400.99356972
46Parkinsons disease_Homo sapiens_hsa050120.89819880
47ErbB signaling pathway_Homo sapiens_hsa040120.89149419
48Melanogenesis_Homo sapiens_hsa049160.88060996
49Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82872691
50Phototransduction_Homo sapiens_hsa047440.82800732
51Alzheimers disease_Homo sapiens_hsa050100.82207183
52Oocyte meiosis_Homo sapiens_hsa041140.79247667
53Glioma_Homo sapiens_hsa052140.73779607
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.72819150
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72649238
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70838365
57Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70139318
58Thyroid hormone synthesis_Homo sapiens_hsa049180.69866370
59Dorso-ventral axis formation_Homo sapiens_hsa043200.65824665
60Pancreatic secretion_Homo sapiens_hsa049720.65529442
61Alcoholism_Homo sapiens_hsa050340.65336237
62Dilated cardiomyopathy_Homo sapiens_hsa054140.64856393
63Butanoate metabolism_Homo sapiens_hsa006500.62461957
64Phospholipase D signaling pathway_Homo sapiens_hsa040720.61919183
65MAPK signaling pathway_Homo sapiens_hsa040100.61345105
66Regulation of autophagy_Homo sapiens_hsa041400.60746499
67Huntingtons disease_Homo sapiens_hsa050160.59061034
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53989060
69Prion diseases_Homo sapiens_hsa050200.53138532
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51044302
71Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49909183
72Rheumatoid arthritis_Homo sapiens_hsa053230.48447868
73Neurotrophin signaling pathway_Homo sapiens_hsa047220.47859356
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47631903
75Ras signaling pathway_Homo sapiens_hsa040140.47606808
76Choline metabolism in cancer_Homo sapiens_hsa052310.47208594
77Phagosome_Homo sapiens_hsa041450.46635267
78Glucagon signaling pathway_Homo sapiens_hsa049220.46617086
79Endocytosis_Homo sapiens_hsa041440.44351914
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43311843
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43245333
82Arginine and proline metabolism_Homo sapiens_hsa003300.42741944
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42087635
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42019447
85Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41729850
86Bile secretion_Homo sapiens_hsa049760.41543764
87Ovarian steroidogenesis_Homo sapiens_hsa049130.41398962
88Nitrogen metabolism_Homo sapiens_hsa009100.41017770
89Histidine metabolism_Homo sapiens_hsa003400.40805862
90Ether lipid metabolism_Homo sapiens_hsa005650.40489334
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40412330
92Mineral absorption_Homo sapiens_hsa049780.39710780
93Insulin signaling pathway_Homo sapiens_hsa049100.38615510
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38238330
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36895623
96Renal cell carcinoma_Homo sapiens_hsa052110.36214948
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34443244
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.33164045
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.32647548
100Inositol phosphate metabolism_Homo sapiens_hsa005620.32623730
101Rap1 signaling pathway_Homo sapiens_hsa040150.32005735
102Wnt signaling pathway_Homo sapiens_hsa043100.31849397
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31511554
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31437316
105Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.30545068
106Endometrial cancer_Homo sapiens_hsa052130.28647065
107Circadian rhythm_Homo sapiens_hsa047100.25353601
108beta-Alanine metabolism_Homo sapiens_hsa004100.25334859
109VEGF signaling pathway_Homo sapiens_hsa043700.23502550
110Arginine biosynthesis_Homo sapiens_hsa002200.22495421
111Fatty acid biosynthesis_Homo sapiens_hsa000610.21713860
112Hippo signaling pathway_Homo sapiens_hsa043900.17199587
113Linoleic acid metabolism_Homo sapiens_hsa005910.14552742

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