TMEM132A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is highly similar to the rat Grp78-binding protein (GBP). Alternatively spliced transcript variants encoding different isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.92562366
2locomotory exploration behavior (GO:0035641)5.73455409
3layer formation in cerebral cortex (GO:0021819)5.68773651
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.59327776
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.27055145
6vocalization behavior (GO:0071625)4.98903710
7regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.92988956
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.89330723
9dendritic spine morphogenesis (GO:0060997)4.89184658
10positive regulation of synapse maturation (GO:0090129)4.69065098
11glutamate secretion (GO:0014047)4.62802754
12synaptic vesicle exocytosis (GO:0016079)4.56230663
13regulation of synapse structural plasticity (GO:0051823)4.45227975
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.44327708
15response to pheromone (GO:0019236)4.42486297
16regulation of glutamate receptor signaling pathway (GO:1900449)4.35832858
17exploration behavior (GO:0035640)4.35301077
18pyrimidine nucleobase catabolic process (GO:0006208)4.35260248
19protein localization to synapse (GO:0035418)4.32524218
20regulation of synaptic vesicle exocytosis (GO:2000300)4.26393373
21planar cell polarity pathway involved in neural tube closure (GO:0090179)4.20836487
22semaphorin-plexin signaling pathway (GO:0071526)4.15817981
23dendrite morphogenesis (GO:0048813)4.15737648
24establishment of nucleus localization (GO:0040023)4.08042455
25sodium ion export (GO:0071436)4.06731176
26cerebellar Purkinje cell layer development (GO:0021680)3.98845655
27regulation of long-term neuronal synaptic plasticity (GO:0048169)3.97541484
28ionotropic glutamate receptor signaling pathway (GO:0035235)3.90367416
29hemidesmosome assembly (GO:0031581)3.89286236
30regulation of neuronal synaptic plasticity (GO:0048168)3.88102550
31cell migration in hindbrain (GO:0021535)3.86303337
32axonal fasciculation (GO:0007413)3.86076562
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81534524
34central nervous system projection neuron axonogenesis (GO:0021952)3.81131101
35neurotransmitter secretion (GO:0007269)3.80323139
36protein retention in ER lumen (GO:0006621)3.78565663
37proline transport (GO:0015824)3.74049028
38regulation of synaptic vesicle transport (GO:1902803)3.73862621
39COPI coating of Golgi vesicle (GO:0048205)3.72002255
40Golgi transport vesicle coating (GO:0048200)3.72002255
41neuron recognition (GO:0008038)3.67235139
42neuromuscular process controlling balance (GO:0050885)3.65336657
43cellular potassium ion homeostasis (GO:0030007)3.65184327
44desmosome organization (GO:0002934)3.62041324
45neuron cell-cell adhesion (GO:0007158)3.61821331
46auditory behavior (GO:0031223)3.61017198
47cell communication by electrical coupling (GO:0010644)3.59703006
48neurotransmitter-gated ion channel clustering (GO:0072578)3.57937021
49cerebellar granule cell differentiation (GO:0021707)3.56532151
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.55424079
51clathrin coat assembly (GO:0048268)3.53981945
52gamma-aminobutyric acid transport (GO:0015812)3.51656883
53nucleobase catabolic process (GO:0046113)3.50453582
54synaptic transmission, glutamatergic (GO:0035249)3.49435535
55glutamate receptor signaling pathway (GO:0007215)3.47302437
56cerebellar Purkinje cell differentiation (GO:0021702)3.42118008
57negative regulation of microtubule polymerization (GO:0031115)3.36785690
58regulation of synapse maturation (GO:0090128)3.36699682
59ear development (GO:0043583)3.35449351
60response to auditory stimulus (GO:0010996)3.35256990
61dendritic spine organization (GO:0097061)3.32736636
62long-term memory (GO:0007616)3.29619824
63dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28651693
64postsynaptic membrane organization (GO:0001941)3.25349799
65regulation of dendritic spine morphogenesis (GO:0061001)3.23689502
66synaptic vesicle endocytosis (GO:0048488)3.22787628
67establishment of apical/basal cell polarity (GO:0035089)3.20803947
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.20699566
69cell-cell junction maintenance (GO:0045217)3.19948498
70activation of protein kinase A activity (GO:0034199)3.19168009
71neuronal ion channel clustering (GO:0045161)3.13909482
72membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.12946310
73regulation of excitatory postsynaptic membrane potential (GO:0060079)3.11449696
74negative regulation of catenin import into nucleus (GO:0035414)3.11269035
75cytoskeletal anchoring at plasma membrane (GO:0007016)3.11095466
76retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04916074
77Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.03993541
78positive regulation of membrane potential (GO:0045838)3.03440666
79axon extension (GO:0048675)3.02097760
80neuron-neuron synaptic transmission (GO:0007270)3.02066170
81positive regulation of dendritic spine development (GO:0060999)3.01382127
82neuronal action potential propagation (GO:0019227)3.01364927
83regulation of synaptic plasticity (GO:0048167)2.96528354
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.95979962
85adherens junction assembly (GO:0034333)2.94642380
86regulation of postsynaptic membrane potential (GO:0060078)2.94080371
87branching involved in salivary gland morphogenesis (GO:0060445)2.93702943
88establishment or maintenance of monopolar cell polarity (GO:0061339)2.92546312
89establishment of monopolar cell polarity (GO:0061162)2.92546312
90regulation of ARF protein signal transduction (GO:0032012)2.87968057
91positive regulation of axon extension (GO:0045773)2.87187423
92negative regulation of cell size (GO:0045792)2.86286008
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.85771239
94epithelial cell-cell adhesion (GO:0090136)2.85644946
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.85583940
96regulation of establishment of planar polarity (GO:0090175)2.85150735
97innervation (GO:0060384)2.85068433
98central nervous system neuron axonogenesis (GO:0021955)2.84757949
99apical protein localization (GO:0045176)2.84697707
100peptidyl-tyrosine autophosphorylation (GO:0038083)2.82230566
101mating behavior (GO:0007617)2.81467629
102synapse organization (GO:0050808)2.81266947
103G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.81226441
104synapse assembly (GO:0007416)2.81027855
105regulation of neurotransmitter secretion (GO:0046928)2.81020417
106cerebellum development (GO:0021549)2.80431816
107neuromuscular process (GO:0050905)2.80238100
108positive regulation of dendrite development (GO:1900006)2.80134579
109cell differentiation in hindbrain (GO:0021533)2.79818868
110cell-substrate junction assembly (GO:0007044)2.79775939
111neurotransmitter transport (GO:0006836)2.79159040
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77960506
113endothelial cell chemotaxis (GO:0035767)2.77785347
114neuron projection extension (GO:1990138)2.77402893
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.76719340
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.76646753
117basement membrane organization (GO:0071711)2.75543176
118regulation of axon extension involved in axon guidance (GO:0048841)2.73574934
119convergent extension (GO:0060026)2.71302315
120regulation of dendritic spine development (GO:0060998)2.70821427
121prepulse inhibition (GO:0060134)2.70346072
122regulation of synapse organization (GO:0050807)2.70329969
123transmission of nerve impulse (GO:0019226)2.70236355
124organelle transport along microtubule (GO:0072384)2.69847137
125neuron projection morphogenesis (GO:0048812)2.69748569
126glycine transport (GO:0015816)2.68691924
127asymmetric protein localization (GO:0008105)2.68327448
128axon cargo transport (GO:0008088)2.66129597
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.66119795
130axon extension involved in axon guidance (GO:0048846)2.64657977
131neuron projection extension involved in neuron projection guidance (GO:1902284)2.64657977
132focal adhesion assembly (GO:0048041)2.62625990
133cell-substrate adherens junction assembly (GO:0007045)2.62625990
134regulation of axon extension (GO:0030516)2.62389517
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62154676
136activation of Rac GTPase activity (GO:0032863)2.61961466
137regulation of synaptic transmission, glutamatergic (GO:0051966)2.61851976
138positive regulation of synaptic transmission, GABAergic (GO:0032230)2.61808279
139mammary gland epithelial cell differentiation (GO:0060644)2.60440998
140dopamine receptor signaling pathway (GO:0007212)2.58583471
141regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58285909
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.55824771
143atrioventricular valve morphogenesis (GO:0003181)2.54564465
144negative regulation of chondrocyte differentiation (GO:0032331)2.53165686
145establishment of mitochondrion localization (GO:0051654)2.51728152
146adherens junction organization (GO:0034332)2.48085686
147branching involved in mammary gland duct morphogenesis (GO:0060444)2.47801607
148establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46819871
149establishment or maintenance of apical/basal cell polarity (GO:0035088)2.46434752
150establishment or maintenance of bipolar cell polarity (GO:0061245)2.46434752
151camera-type eye morphogenesis (GO:0048593)2.45206170
152polarized epithelial cell differentiation (GO:0030859)2.42543438
153cell junction maintenance (GO:0034331)2.41694204
154negative regulation of axon extension involved in axon guidance (GO:0048843)2.39225396
155cochlea morphogenesis (GO:0090103)2.38859970
156cell adhesion mediated by integrin (GO:0033627)2.38362387
157amino acid import (GO:0043090)2.36867964
158non-canonical Wnt signaling pathway (GO:0035567)2.36658084
159protein localization to endosome (GO:0036010)2.36602513
160regulation of axon guidance (GO:1902667)2.36571817
161establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.33725158
162mitochondrion transport along microtubule (GO:0047497)2.33725158
163maternal placenta development (GO:0001893)2.32986692
164adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.32658472
165heparan sulfate proteoglycan metabolic process (GO:0030201)2.31362919
166neuromuscular junction development (GO:0007528)2.30663955

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.41054359
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.96541114
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.48329108
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.97521172
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95694398
6* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.92894061
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.91147451
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.91147451
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87700954
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.70775344
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.63327775
12DROSHA_22980978_ChIP-Seq_HELA_Human2.61807510
13MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.61285959
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56033062
15RARB_27405468_Chip-Seq_BRAIN_Mouse2.54607039
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.48196772
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.44617678
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44158025
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42975347
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.42526863
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41665998
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.41387178
23CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38899103
24REST_21632747_ChIP-Seq_MESCs_Mouse2.36729931
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.33379029
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.32085294
27RARG_19884340_ChIP-ChIP_MEFs_Mouse2.29747594
28RACK7_27058665_Chip-Seq_MCF-7_Human2.27572049
29ZFP281_18757296_ChIP-ChIP_E14_Mouse2.23331829
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.22741749
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.16689462
32REST_18959480_ChIP-ChIP_MESCs_Mouse2.09308191
33ESR1_20079471_ChIP-ChIP_T-47D_Human2.06278869
34ESR1_21235772_ChIP-Seq_MCF-7_Human2.02310816
35* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.01454024
36ESR1_15608294_ChIP-ChIP_MCF-7_Human2.00241228
37KDM2B_26808549_Chip-Seq_K562_Human1.96234982
38GBX2_23144817_ChIP-Seq_PC3_Human1.94667323
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.91480114
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.81045719
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76945432
42ZFP281_27345836_Chip-Seq_ESCs_Mouse1.69762121
43RING1B_27294783_Chip-Seq_ESCs_Mouse1.69020270
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.65865428
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.64291455
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.62602663
47* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61159451
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60481264
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.59725075
50ZNF274_21170338_ChIP-Seq_K562_Hela1.57974149
51RING1B_27294783_Chip-Seq_NPCs_Mouse1.57668672
52PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54400499
53EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.50274740
54TET1_21451524_ChIP-Seq_MESCs_Mouse1.47968488
55RUNX1_27514584_Chip-Seq_MCF-7_Human1.47216881
56SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.45272090
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.43422524
58PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.42693484
59TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39218466
60RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38935631
61TP53_22127205_ChIP-Seq_IMR90_Human1.37581277
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.36783259
63DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.36228453
64RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.34627395
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.33579454
66AR_21572438_ChIP-Seq_LNCaP_Human1.33305078
67KDM2B_26808549_Chip-Seq_DND41_Human1.32208870
68RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31839713
69WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31236066
70P68_20966046_ChIP-Seq_HELA_Human1.29374137
71CLOCK_20551151_ChIP-Seq_293T_Human1.28290124
72* LXR_22292898_ChIP-Seq_THP-1_Human1.28250714
73KDM2B_26808549_Chip-Seq_JURKAT_Human1.24996822
74SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24285048
75CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.22791586
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22568637
77AR_19668381_ChIP-Seq_PC3_Human1.22140405
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21789322
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21715768
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.20354145
81POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20208464
82KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20060297
83GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19636451
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19619759
85CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16771337
86TCF7_22412390_ChIP-Seq_EML_Mouse1.14351027
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.13529156
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.12450798
89* SA1_27219007_Chip-Seq_ERYTHROID_Human1.10501593
90DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08858115
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08567772
92CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07860250
93* TET1_21490601_ChIP-Seq_MESCs_Mouse1.07684099
94SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07368114
95* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06645246
96TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06562934
97SOX2_21211035_ChIP-Seq_LN229_Gbm1.06101167
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05591836
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04637111
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02206609
101* CTCF_27219007_Chip-Seq_Bcells_Human1.00277198
102STAT6_21828071_ChIP-Seq_BEAS2B_Human1.00065418
103CTBP2_25329375_ChIP-Seq_LNCAP_Human0.99312208
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99202387
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98623867
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.98038572
107NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97892196
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96834470
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96028497
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94956404
111NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93349008
112SMAD4_21741376_ChIP-Seq_HESCs_Human0.91191654
113NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.91065990
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.91027817
115SMAD3_21741376_ChIP-Seq_ESCs_Human0.90228586
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89922283
117TRIM28_21343339_ChIP-Seq_HEK293_Human0.89350014
118SMC4_20622854_ChIP-Seq_HELA_Human0.88276419
119CREB1_26743006_Chip-Seq_LNCaP_Human0.88248950
120ARNT_22903824_ChIP-Seq_MCF-7_Human0.86813842
121P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86282582
122* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.84534109
123RNF2_27304074_Chip-Seq_NSC_Mouse0.84344335
124AHR_22903824_ChIP-Seq_MCF-7_Human0.83520032
125ISL1_27105846_Chip-Seq_CPCs_Mouse0.83468274
126SMAD4_21799915_ChIP-Seq_A2780_Human0.80827885
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.80156212
128TP53_23651856_ChIP-Seq_MEFs_Mouse0.79682946
129CTBP1_25329375_ChIP-Seq_LNCAP_Human0.79552946
130KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79226389
131ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.78995053
132SMAD3_21741376_ChIP-Seq_HESCs_Human0.78816164
133AR_25329375_ChIP-Seq_VCAP_Human0.76942178
134ESR2_21235772_ChIP-Seq_MCF-7_Human0.76308969
135ZNF263_19887448_ChIP-Seq_K562_Human0.76210961
136KLF4_19829295_ChIP-Seq_ESCs_Human0.75186053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.65522504
2MP0003635_abnormal_synaptic_transmissio3.82299451
3MP0004270_analgesia3.44561748
4MP0003880_abnormal_central_pattern3.20398211
5MP0002063_abnormal_learning/memory/cond3.08872412
6MP0000579_abnormal_nail_morphology2.92798972
7MP0005423_abnormal_somatic_nervous2.88911820
8MP0009745_abnormal_behavioral_response2.68501719
9MP0000778_abnormal_nervous_system2.58309270
10MP0004858_abnormal_nervous_system2.53118814
11MP0002064_seizures2.49188082
12MP0009046_muscle_twitch2.47527384
13MP0000569_abnormal_digit_pigmentation2.31632192
14MP0000566_synostosis2.27947165
15MP0002734_abnormal_mechanical_nocicepti2.27027994
16MP0002572_abnormal_emotion/affect_behav2.23569352
17MP0002184_abnormal_innervation2.16224690
18MP0009780_abnormal_chondrocyte_physiolo2.11220865
19MP0001968_abnormal_touch/_nociception2.07542374
20MP0003283_abnormal_digestive_organ2.04719491
21MP0003329_amyloid_beta_deposits2.02064538
22MP0004811_abnormal_neuron_physiology1.98636026
23MP0004272_abnormal_basement_membrane1.95689003
24MP0005409_darkened_coat_color1.93676967
25MP0001486_abnormal_startle_reflex1.92826844
26MP0001440_abnormal_grooming_behavior1.92106089
27MP0003122_maternal_imprinting1.90467900
28MP0008569_lethality_at_weaning1.90452397
29MP0008438_abnormal_cutaneous_collagen1.87077324
30MP0000955_abnormal_spinal_cord1.85756445
31MP0002733_abnormal_thermal_nociception1.79660856
32MP0002272_abnormal_nervous_system1.69620924
33MP0002249_abnormal_larynx_morphology1.69321366
34MP0002796_impaired_skin_barrier1.68437478
35MP0002557_abnormal_social/conspecific_i1.67020120
36MP0002098_abnormal_vibrissa_morphology1.65305111
37MP0003566_abnormal_cell_adhesion1.64435806
38MP0005257_abnormal_intraocular_pressure1.63775308
39MP0002909_abnormal_adrenal_gland1.60435807
40MP0000762_abnormal_tongue_morphology1.59984759
41MP0001346_abnormal_lacrimal_gland1.59598472
42MP0005623_abnormal_meninges_morphology1.59185257
43MP0002735_abnormal_chemical_nociception1.58370891
44MP0002067_abnormal_sensory_capabilities1.54820848
45MP0001970_abnormal_pain_threshold1.52334098
46MP0002736_abnormal_nociception_after1.50465453
47MP0008961_abnormal_basal_metabolism1.50175875
48MP0002882_abnormal_neuron_morphology1.49857374
49MP0003879_abnormal_hair_cell1.47970773
50MP0000537_abnormal_urethra_morphology1.44228358
51MP0002152_abnormal_brain_morphology1.41427890
52MP0001501_abnormal_sleep_pattern1.41235672
53MP0005386_behavior/neurological_phenoty1.38813409
54MP0004924_abnormal_behavior1.38813409
55MP0000462_abnormal_digestive_system1.37442822
56MP0009384_cardiac_valve_regurgitation1.36086761
57MP0004885_abnormal_endolymph1.35591172
58MP0002254_reproductive_system_inflammat1.34084578
59MP0005248_abnormal_Harderian_gland1.30993049
60MP0002066_abnormal_motor_capabilities/c1.30463328
61MP0001299_abnormal_eye_distance/1.29106855
62MP0004264_abnormal_extraembryonic_tissu1.28314515
63MP0001348_abnormal_lacrimal_gland1.24348872
64MP0005501_abnormal_skin_physiology1.23574061
65MP0000467_abnormal_esophagus_morphology1.23417352
66MP0003861_abnormal_nervous_system1.21883369
67MP0005187_abnormal_penis_morphology1.18942017
68MP0004233_abnormal_muscle_weight1.17777319
69MP0002089_abnormal_postnatal_growth/wei1.15228752
70MP0010030_abnormal_orbit_morphology1.13604699
71MP0002822_catalepsy1.13397276
72MP0000751_myopathy1.12878006
73MP0004145_abnormal_muscle_electrophysio1.12408445
74MP0002234_abnormal_pharynx_morphology1.12080842
75MP0006276_abnormal_autonomic_nervous1.11570282
76MP0002060_abnormal_skin_morphology1.08572595
77MP0002896_abnormal_bone_mineralization1.07049809
78MP0009053_abnormal_anal_canal1.06590014
79MP0003385_abnormal_body_wall1.05399750
80MP0003119_abnormal_digestive_system1.05370822
81MP0003453_abnormal_keratinocyte_physiol1.05087998
82MP0002653_abnormal_ependyma_morphology1.04737456
83MP0000678_abnormal_parathyroid_gland1.01363809
84MP0002116_abnormal_craniofacial_bone0.98797493
85MP0001502_abnormal_circadian_rhythm0.98778273
86MP0003633_abnormal_nervous_system0.97535546
87MP0003137_abnormal_impulse_conducting0.97483042
88MP0000534_abnormal_ureter_morphology0.97157205
89MP0002697_abnormal_eye_size0.95878334
90MP0003632_abnormal_nervous_system0.95780492
91MP0010678_abnormal_skin_adnexa0.95411193
92MP0000627_abnormal_mammary_gland0.93961984
93MP0003705_abnormal_hypodermis_morpholog0.93871828
94MP0003634_abnormal_glial_cell0.93631831
95MP0003631_nervous_system_phenotype0.92970638
96MP0003941_abnormal_skin_development0.92758231
97MP0005076_abnormal_cell_differentiation0.92001366
98MP0003279_aneurysm0.91885437
99MP0000377_abnormal_hair_follicle0.91735253
100MP0003755_abnormal_palate_morphology0.91212370
101MP0005058_abnormal_lysosome_morphology0.89041353
102MP0010771_integument_phenotype0.88734350
103MP0003172_abnormal_lysosome_physiology0.88442230
104MP0000604_amyloidosis0.87155101
105MP0001340_abnormal_eyelid_morphology0.86880081
106MP0002069_abnormal_eating/drinking_beha0.86306356
107MP0003091_abnormal_cell_migration0.83513514
108MP0009672_abnormal_birth_weight0.83221469
109MP0000631_abnormal_neuroendocrine_gland0.83005522
110MP0001984_abnormal_olfaction0.82865499
111MP0005508_abnormal_skeleton_morphology0.82834800
112MP0003787_abnormal_imprinting0.82680987
113MP0002877_abnormal_melanocyte_morpholog0.82507131
114MP0000003_abnormal_adipose_tissue0.81790503
115MP0000049_abnormal_middle_ear0.81713952
116MP0010234_abnormal_vibrissa_follicle0.81306822
117MP0005645_abnormal_hypothalamus_physiol0.80740857
118MP0005499_abnormal_olfactory_system0.80062142
119MP0005394_taste/olfaction_phenotype0.80062142
120MP0001177_atelectasis0.79474900
121MP0000428_abnormal_craniofacial_morphol0.78457331
122MP0003121_genomic_imprinting0.78061233
123MP0003115_abnormal_respiratory_system0.77630857
124MP0001849_ear_inflammation0.76975996
125MP0002081_perinatal_lethality0.76618047
126MP0005275_abnormal_skin_tensile0.76570326
127MP0000538_abnormal_urinary_bladder0.76077921
128MP0002752_abnormal_somatic_nervous0.75602067
129MP0003935_abnormal_craniofacial_develop0.74786107
130MP0001958_emphysema0.72951143
131MP0002751_abnormal_autonomic_nervous0.72537608
132MP0001529_abnormal_vocalization0.71896977
133MP0003942_abnormal_urinary_system0.69930389
134MP0004085_abnormal_heartbeat0.69722071
135MP0004742_abnormal_vestibular_system0.69251764
136MP0003303_peritoneal_inflammation0.68867094
137MP0003075_altered_response_to0.68705200
138MP0010769_abnormal_survival0.68378447
139MP0004133_heterotaxia0.66881033
140MP0003123_paternal_imprinting0.65386728
141MP0002082_postnatal_lethality0.65150928
142MP0010770_preweaning_lethality0.65150928
143MP0002090_abnormal_vision0.64324447
144MP0001943_abnormal_respiration0.64067490
145MP0000013_abnormal_adipose_tissue0.63584745
146MP0000733_abnormal_muscle_development0.63211988
147MP0010768_mortality/aging0.62982386

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.83777019
2Visual hallucinations (HP:0002367)4.73316223
3Focal motor seizures (HP:0011153)4.32759375
4Focal seizures (HP:0007359)4.17673709
5Premature rupture of membranes (HP:0001788)3.62052023
6Supranuclear gaze palsy (HP:0000605)3.39540605
7Action tremor (HP:0002345)3.32544566
8Mutism (HP:0002300)3.30753486
9Abnormality of the lower motor neuron (HP:0002366)3.24840178
10Atrophic scars (HP:0001075)3.16408336
11Progressive cerebellar ataxia (HP:0002073)3.13573076
12Ankle clonus (HP:0011448)3.00602119
13Amyotrophic lateral sclerosis (HP:0007354)2.96412479
14Absence seizures (HP:0002121)2.84094024
15Epileptic encephalopathy (HP:0200134)2.83789759
16Pointed chin (HP:0000307)2.80816844
17Insomnia (HP:0100785)2.77839391
18Shallow orbits (HP:0000586)2.70211081
19Cerebral aneurysm (HP:0004944)2.69039290
20Genetic anticipation (HP:0003743)2.68963161
21Papilledema (HP:0001085)2.68737639
22Protrusio acetabuli (HP:0003179)2.67121641
23Hyperacusis (HP:0010780)2.65267643
24Poor eye contact (HP:0000817)2.61950682
25Fragile skin (HP:0001030)2.61900909
26Bronchomalacia (HP:0002780)2.59841833
27Cervical subluxation (HP:0003308)2.55701234
28Depression (HP:0000716)2.54436838
29Broad-based gait (HP:0002136)2.49907157
30Bladder diverticulum (HP:0000015)2.46619712
31Neoplasm of the heart (HP:0100544)2.44279064
32Megalencephaly (HP:0001355)2.42499586
33Congenital glaucoma (HP:0001087)2.41637978
34Hemiplegia (HP:0002301)2.41274825
35Dialeptic seizures (HP:0011146)2.41109497
36Cerebral inclusion bodies (HP:0100314)2.38583633
37Apathy (HP:0000741)2.37095883
38Broad face (HP:0000283)2.36332394
39Hemiparesis (HP:0001269)2.34706951
40Impaired social interactions (HP:0000735)2.34491186
41Abnormal social behavior (HP:0012433)2.34491186
42Thin bony cortex (HP:0002753)2.32820826
43Flat acetabular roof (HP:0003180)2.32712019
44Abnormal eating behavior (HP:0100738)2.31604944
45Renal duplication (HP:0000075)2.29961390
46Torticollis (HP:0000473)2.29194841
47Asymmetry of the thorax (HP:0001555)2.29150753
48Excessive salivation (HP:0003781)2.28636723
49Drooling (HP:0002307)2.28636723
50Ulnar bowing (HP:0003031)2.27957466
51Elfin facies (HP:0004428)2.27048734
52Generalized tonic-clonic seizures (HP:0002069)2.26805591
53Obstructive sleep apnea (HP:0002870)2.26546358
54Impaired vibration sensation in the lower limbs (HP:0002166)2.24649103
55Urinary bladder sphincter dysfunction (HP:0002839)2.23815335
56Dysdiadochokinesis (HP:0002075)2.22097751
57Impaired smooth pursuit (HP:0007772)2.21029854
58Broad metatarsal (HP:0001783)2.19895640
59Urinary urgency (HP:0000012)2.19590006
60Neurofibrillary tangles (HP:0002185)2.19103580
61Lymphangioma (HP:0100764)2.17816754
62Buphthalmos (HP:0000557)2.16436331
63Diplopia (HP:0000651)2.15376806
64Abnormality of binocular vision (HP:0011514)2.15376806
65Akinesia (HP:0002304)2.15344758
66Atonic seizures (HP:0010819)2.14799796
67Annular pancreas (HP:0001734)2.14349138
68Amblyopia (HP:0000646)2.13590303
69Aplasia involving bones of the extremities (HP:0009825)2.13162031
70Aplasia involving bones of the upper limbs (HP:0009823)2.13162031
71Aplasia of the phalanges of the hand (HP:0009802)2.13162031
72Arterial tortuosity (HP:0005116)2.13013801
73Diminished motivation (HP:0000745)2.12677597
74Ankyloglossia (HP:0010296)2.12535254
75Abnormality of dentin (HP:0010299)2.11716345
76Truncal ataxia (HP:0002078)2.11220569
77Long palpebral fissure (HP:0000637)2.09375056
78Fetal akinesia sequence (HP:0001989)2.07073570
79Abnormality of the corticospinal tract (HP:0002492)2.07063914
80Pterygium (HP:0001059)2.06245747
81Overriding aorta (HP:0002623)2.06155649
82Distal lower limb muscle weakness (HP:0009053)2.04177131
83Advanced eruption of teeth (HP:0006288)2.03841883
84Gaze-evoked nystagmus (HP:0000640)2.03821485
85Flattened epiphyses (HP:0003071)2.02970515
86Aqueductal stenosis (HP:0002410)2.02917210
87Stereotypic behavior (HP:0000733)2.01411177
88Febrile seizures (HP:0002373)2.01400362
89Inappropriate behavior (HP:0000719)2.01346691
90Polyphagia (HP:0002591)2.00102688
91Renovascular hypertension (HP:0100817)1.99967813
92Turricephaly (HP:0000262)1.99867223
93Fragile nails (HP:0001808)1.99473725
94Spastic gait (HP:0002064)1.98962190
95Abnormality of ocular smooth pursuit (HP:0000617)1.98913318
96Focal dystonia (HP:0004373)1.98164097
97Spinal rigidity (HP:0003306)1.98116909
98Astrocytoma (HP:0009592)1.97985009
99Abnormality of the astrocytes (HP:0100707)1.97985009
100Dysmetria (HP:0001310)1.96988311
101Postural instability (HP:0002172)1.96622284
102Agitation (HP:0000713)1.96104551
103Short 4th metacarpal (HP:0010044)1.95670006
104Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.95670006
105Lower limb amyotrophy (HP:0007210)1.95365232
106Dysmetric saccades (HP:0000641)1.94404020
107Ankle contracture (HP:0006466)1.94135190
108Intention tremor (HP:0002080)1.93753655
109Short nail (HP:0001799)1.93120496
110Macroorchidism (HP:0000053)1.92652575
111Arnold-Chiari malformation (HP:0002308)1.91832834
112Mitral regurgitation (HP:0001653)1.89782183
113Insidious onset (HP:0003587)1.88954393
114Termporal pattern (HP:0011008)1.88954393
115Exostoses (HP:0100777)1.87843641
116Pili torti (HP:0003777)1.87376686
117Hypoplasia of the brainstem (HP:0002365)1.86954180
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86954180
119Vascular tortuosity (HP:0004948)1.86393814
120Distal lower limb amyotrophy (HP:0008944)1.85903543
121Upper limb amyotrophy (HP:0009129)1.85856392
122Distal upper limb amyotrophy (HP:0007149)1.85856392
123Blue sclerae (HP:0000592)1.85227124
124Concave nail (HP:0001598)1.85215712
125Vitreoretinal degeneration (HP:0000655)1.84671323
126Large eyes (HP:0001090)1.83433224
127Limb dystonia (HP:0002451)1.83014399
128Achilles tendon contracture (HP:0001771)1.82594107
129Hypoventilation (HP:0002791)1.82233316
130Right ventricular cardiomyopathy (HP:0011663)1.81546690
131Shoulder girdle muscle weakness (HP:0003547)1.80680482
132Hyperparathyroidism (HP:0000843)1.80337018
133Mildly elevated creatine phosphokinase (HP:0008180)1.80307324
134Genu recurvatum (HP:0002816)1.80122256
135Bowel diverticulosis (HP:0005222)1.79475754
136Stridor (HP:0010307)1.78693818
137Craniofacial dystonia (HP:0012179)1.77864797
138Rapidly progressive (HP:0003678)1.77225219
139Milia (HP:0001056)1.77203921
140Spinal cord compression (HP:0002176)1.76660184
141Hepatoblastoma (HP:0002884)1.76219769
142Lower limb muscle weakness (HP:0007340)1.76050168
143Hand muscle atrophy (HP:0009130)1.75244880
144Natal tooth (HP:0000695)1.74970006
145Flat cornea (HP:0007720)1.74115182
146Neuronal loss in central nervous system (HP:0002529)1.73900151
147Neonatal short-limb short stature (HP:0008921)1.73899787
148Sacral dimple (HP:0000960)1.72497066
149Ventricular fibrillation (HP:0001663)1.72474765
150Intellectual disability, profound (HP:0002187)1.72381720
151Difficulty climbing stairs (HP:0003551)1.71703113
152Germ cell neoplasia (HP:0100728)1.71410058
153Patellar dislocation (HP:0002999)1.71372401
154Precocious puberty (HP:0000826)1.71356854
155Long toe (HP:0010511)1.70958227
156Abnormality of the distal phalanx of the thumb (HP:0009617)1.68764341
157J-shaped sella turcica (HP:0002680)1.68170063
158Selective tooth agenesis (HP:0001592)1.65945221
159Abnormality of the distal phalanges of the toes (HP:0010182)1.64818556
160Abnormality of nail color (HP:0100643)1.63411202
161Disproportionate tall stature (HP:0001519)1.61595797
162Hallux valgus (HP:0001822)1.59897630
163Enlarged penis (HP:0000040)1.59099603
164Partial duplication of thumb phalanx (HP:0009944)1.59053934
165Hyperextensible skin (HP:0000974)1.56963793
166Thin ribs (HP:0000883)1.56792820
167Deviation of the hallux (HP:0010051)1.55948835
168Coronal craniosynostosis (HP:0004440)1.55357560
169Partial duplication of the phalanx of hand (HP:0009999)1.53876607
170Wormian bones (HP:0002645)1.52906739
171Adducted thumb (HP:0001181)1.52794843
172Back pain (HP:0003418)1.52147929
173Hypercalcemia (HP:0003072)1.52109563
174Broad distal phalanx of finger (HP:0009836)1.50804682
175Protruding ear (HP:0000411)1.50692002
176Abnormality of the Achilles tendon (HP:0005109)1.50655957

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.07658416
2EPHA24.24067091
3MAP3K94.09294065
4SIK13.41580639
5MINK12.80783672
6NTRK32.77208106
7PAK62.61815502
8NTRK22.50604355
9EPHA42.46242297
10KSR12.44498323
11DAPK22.41082349
12RIPK12.21160357
13MAP3K42.05592974
14LATS22.04118329
15CAMKK12.02024545
16SMG11.93829482
17TYRO31.92631263
18PRKD31.84824233
19KSR21.83770033
20MST1R1.76089583
21SIK21.74990416
22TRIB31.64002091
23FGFR41.57925288
24NTRK11.53918179
25MET1.50982037
26EPHB21.49225561
27UHMK11.45214099
28CDK51.42905386
29PHKG11.40618295
30PHKG21.40618295
31TAOK11.37284762
32CDK181.30928134
33ALK1.30868278
34PDGFRA1.28633178
35MAPKAPK31.27801997
36CDK151.26372052
37MAP2K71.22407062
38MAP2K41.21287196
39PAK41.19982571
40DDR21.17748779
41ICK1.17470552
42CDK141.16968489
43ARAF1.16106658
44STK381.13615746
45ERBB31.13188469
46SIK31.12477652
47CDK11A1.11515101
48TTN1.11322126
49MAPK131.10761980
50MTOR1.10318662
51PAK31.09204650
52IRAK31.08604538
53DAPK11.04370770
54DYRK21.01952124
55MARK21.01792166
56NEK61.00697942
57PKN20.99577127
58CASK0.99545403
59RET0.98381068
60PLK20.98008599
61PRPF4B0.97408337
62CAMKK20.96221972
63NEK10.94937739
64CDK120.94394079
65SCYL20.93824906
66FGFR20.93435694
67STK110.89228065
68PRKCG0.88698792
69EPHB10.88365453
70PRKD20.87484354
71CAMK1G0.87056249
72CAMK2B0.86934348
73RPS6KB20.83778071
74CDK190.82026007
75CSNK1G20.81898618
76MAP3K100.79002754
77PRKCH0.78115948
78PRKCI0.77993767
79CAMK2G0.77830871
80ERN10.77311066
81TESK20.76523584
82FER0.73261977
83ERBB20.71480022
84CAMK10.70253292
85RPS6KA20.69623803
86BCR0.68525760
87MAP3K20.67824341
88MAP3K120.67783368
89LIMK10.67474857
90DYRK1A0.65078885
91ILK0.64761153
92PNCK0.63392732
93PRKCZ0.61917998
94DMPK0.61638248
95MAPK150.60405067
96CDC42BPA0.60335958
97LMTK20.59479447
98FYN0.58840662
99PTK20.58789386
100PAK20.58696437
101CAMK1D0.57232396
102GRK50.56789774
103PTK60.56242651
104FGFR10.56186513
105MUSK0.56121965
106NME20.53108080
107MAP2K20.50112631
108EEF2K0.49972828
109BMX0.49724564
110DAPK30.47289073
111MAP3K60.47155606
112CAMK2A0.46124485
113SGK10.45614094
114RPS6KA30.45052476
115CAMK40.45013006
116MAPK90.44533222
117TAOK20.44419948
118MAPK100.43715182
119BRSK10.43460832
120CAMK2D0.43409510
121TESK10.42587899
122RPS6KC10.40211377
123RPS6KL10.40211377
124PRKD10.39796197
125BRAF0.39601857
126CSNK1A1L0.38704119
127PRKG20.38189972
128PDPK10.37756917
129TNIK0.37176073
130SRC0.37093271
131ROCK10.36803551
132ROCK20.35552775
133DYRK1B0.34815598
134PDGFRB0.34615439
135MAPK80.34505354
136MAP3K110.33751531
137PTK2B0.33382304
138PKN10.32669816
139MAP3K70.32640181
140CSNK1G30.32628851

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.78348297
2Synaptic vesicle cycle_Homo sapiens_hsa047212.74582096
3Circadian entrainment_Homo sapiens_hsa047132.28859326
4Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21640165
5Glutamatergic synapse_Homo sapiens_hsa047242.19361883
6GABAergic synapse_Homo sapiens_hsa047272.16515708
7Long-term potentiation_Homo sapiens_hsa047202.11448472
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04534897
9Olfactory transduction_Homo sapiens_hsa047402.03278446
10Morphine addiction_Homo sapiens_hsa050321.96046246
11Dopaminergic synapse_Homo sapiens_hsa047281.88257633
12Amphetamine addiction_Homo sapiens_hsa050311.79009597
13Axon guidance_Homo sapiens_hsa043601.78824737
14ECM-receptor interaction_Homo sapiens_hsa045121.78127009
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.72212137
16Cholinergic synapse_Homo sapiens_hsa047251.71964164
17Salivary secretion_Homo sapiens_hsa049701.69813781
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.67337687
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.59856476
20Insulin secretion_Homo sapiens_hsa049111.58095689
21Gastric acid secretion_Homo sapiens_hsa049711.57429544
22Oxytocin signaling pathway_Homo sapiens_hsa049211.52645906
23Cocaine addiction_Homo sapiens_hsa050301.50770399
24Gap junction_Homo sapiens_hsa045401.50595640
25Long-term depression_Homo sapiens_hsa047301.50056706
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.48936612
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43067754
28Glioma_Homo sapiens_hsa052141.40820098
29Estrogen signaling pathway_Homo sapiens_hsa049151.39315389
30GnRH signaling pathway_Homo sapiens_hsa049121.37771463
31Bladder cancer_Homo sapiens_hsa052191.34726488
32Type II diabetes mellitus_Homo sapiens_hsa049301.32166900
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.31938886
34Melanogenesis_Homo sapiens_hsa049161.22666314
35Renin secretion_Homo sapiens_hsa049241.20469884
36ErbB signaling pathway_Homo sapiens_hsa040121.18932800
37Endometrial cancer_Homo sapiens_hsa052131.13713505
38Glycosaminoglycan degradation_Homo sapiens_hsa005311.13383768
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.12959540
40Thyroid cancer_Homo sapiens_hsa052161.10772452
41Taste transduction_Homo sapiens_hsa047421.10054560
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.09190463
43cAMP signaling pathway_Homo sapiens_hsa040241.08465512
44Calcium signaling pathway_Homo sapiens_hsa040201.08048464
45Serotonergic synapse_Homo sapiens_hsa047261.05754944
46Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04936205
47Oocyte meiosis_Homo sapiens_hsa041141.02022625
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.01283640
49Dilated cardiomyopathy_Homo sapiens_hsa054141.01234474
50mTOR signaling pathway_Homo sapiens_hsa041501.00896495
51Colorectal cancer_Homo sapiens_hsa052101.00805293
52Basal cell carcinoma_Homo sapiens_hsa052171.00691504
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.00175289
54Adherens junction_Homo sapiens_hsa045200.98462002
55VEGF signaling pathway_Homo sapiens_hsa043700.96963426
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96873708
57cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96631420
58AMPK signaling pathway_Homo sapiens_hsa041520.96135524
59Hippo signaling pathway_Homo sapiens_hsa043900.95558151
60Vitamin B6 metabolism_Homo sapiens_hsa007500.93154296
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92521089
62Hedgehog signaling pathway_Homo sapiens_hsa043400.88150267
63Amoebiasis_Homo sapiens_hsa051460.87832543
64Renal cell carcinoma_Homo sapiens_hsa052110.87822087
65Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87701580
66Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.86252255
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.85464720
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85409286
69Small cell lung cancer_Homo sapiens_hsa052220.84340944
70Dorso-ventral axis formation_Homo sapiens_hsa043200.82571869
71Prolactin signaling pathway_Homo sapiens_hsa049170.82380476
72MicroRNAs in cancer_Homo sapiens_hsa052060.82327110
73Wnt signaling pathway_Homo sapiens_hsa043100.80710250
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.80668357
75MAPK signaling pathway_Homo sapiens_hsa040100.80158542
76AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.80103513
77Choline metabolism in cancer_Homo sapiens_hsa052310.78856326
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76934812
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.75887397
80Rap1 signaling pathway_Homo sapiens_hsa040150.75300628
81Non-small cell lung cancer_Homo sapiens_hsa052230.75094165
82Endocytosis_Homo sapiens_hsa041440.74730845
83Proteoglycans in cancer_Homo sapiens_hsa052050.74730258
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74466934
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73548014
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72601093
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.72156859
88Inositol phosphate metabolism_Homo sapiens_hsa005620.70845461
89Thyroid hormone synthesis_Homo sapiens_hsa049180.70746543
90Melanoma_Homo sapiens_hsa052180.70368892
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67865929
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.67066333
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.67019982
94Pancreatic cancer_Homo sapiens_hsa052120.65485242
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65374717
96Fructose and mannose metabolism_Homo sapiens_hsa000510.65074299
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.65034260
98Chronic myeloid leukemia_Homo sapiens_hsa052200.64744703
99Alcoholism_Homo sapiens_hsa050340.64025014
100N-Glycan biosynthesis_Homo sapiens_hsa005100.63833853
101Pathways in cancer_Homo sapiens_hsa052000.63131597
102Protein digestion and absorption_Homo sapiens_hsa049740.62312228
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.62037380
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.61726261
105Bile secretion_Homo sapiens_hsa049760.61408687
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61295486
107Pancreatic secretion_Homo sapiens_hsa049720.59511235
108Galactose metabolism_Homo sapiens_hsa000520.59159657
109Ras signaling pathway_Homo sapiens_hsa040140.59140956
110Focal adhesion_Homo sapiens_hsa045100.58722570
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57767051
112Notch signaling pathway_Homo sapiens_hsa043300.57316772
113Insulin signaling pathway_Homo sapiens_hsa049100.57198797
114Prion diseases_Homo sapiens_hsa050200.56753776
115Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55584797
116Vibrio cholerae infection_Homo sapiens_hsa051100.55436400
117Collecting duct acid secretion_Homo sapiens_hsa049660.54639320
118Tight junction_Homo sapiens_hsa045300.54597411
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53213657
120Cardiac muscle contraction_Homo sapiens_hsa042600.52370408
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51830508
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.51765395
123Glucagon signaling pathway_Homo sapiens_hsa049220.47546865
124Nitrogen metabolism_Homo sapiens_hsa009100.46659780
125Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46654918
126Chemokine signaling pathway_Homo sapiens_hsa040620.45889108

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