

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | locomotory exploration behavior (GO:0035641) | 5.69921159 |
| 2 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.47187956 |
| 3 | neuron cell-cell adhesion (GO:0007158) | 5.45848772 |
| 4 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.35933620 |
| 5 | vocalization behavior (GO:0071625) | 5.34432049 |
| 6 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.09097415 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 4.92121156 |
| 8 | synaptic vesicle maturation (GO:0016188) | 4.87532492 |
| 9 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.77620302 |
| 10 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.76133834 |
| 11 | glutamate secretion (GO:0014047) | 4.69279972 |
| 12 | protein localization to synapse (GO:0035418) | 4.66088413 |
| 13 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.60501391 |
| 14 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.53960626 |
| 15 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.50691262 |
| 16 | neuronal action potential propagation (GO:0019227) | 4.43873559 |
| 17 | exploration behavior (GO:0035640) | 4.32806909 |
| 18 | presynaptic membrane assembly (GO:0097105) | 4.29337391 |
| 19 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.28313678 |
| 20 | synaptic transmission, glutamatergic (GO:0035249) | 4.24385881 |
| 21 | regulation of neuronal synaptic plasticity (GO:0048168) | 4.23368744 |
| 22 | glutamate receptor signaling pathway (GO:0007215) | 4.23354459 |
| 23 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 4.23031265 |
| 24 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.20176515 |
| 25 | dendritic spine morphogenesis (GO:0060997) | 4.10093632 |
| 26 | neuron-neuron synaptic transmission (GO:0007270) | 4.09067831 |
| 27 | regulation of synaptic vesicle transport (GO:1902803) | 4.02287653 |
| 28 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 4.02258677 |
| 29 | presynaptic membrane organization (GO:0097090) | 3.96628693 |
| 30 | L-amino acid import (GO:0043092) | 3.89119735 |
| 31 | transmission of nerve impulse (GO:0019226) | 3.86444654 |
| 32 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.81010120 |
| 33 | regulation of synapse structural plasticity (GO:0051823) | 3.79307529 |
| 34 | neuron recognition (GO:0008038) | 3.78239313 |
| 35 | positive regulation of membrane potential (GO:0045838) | 3.78032829 |
| 36 | neurotransmitter secretion (GO:0007269) | 3.76959239 |
| 37 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.73566031 |
| 38 | long-term memory (GO:0007616) | 3.70631297 |
| 39 | long-term synaptic potentiation (GO:0060291) | 3.70424356 |
| 40 | gamma-aminobutyric acid transport (GO:0015812) | 3.67241278 |
| 41 | nucleobase catabolic process (GO:0046113) | 3.65716988 |
| 42 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.65353881 |
| 43 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 3.64865754 |
| 44 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.64615618 |
| 45 | postsynaptic membrane organization (GO:0001941) | 3.62891371 |
| 46 | regulation of postsynaptic membrane potential (GO:0060078) | 3.59873185 |
| 47 | regulation of synaptic plasticity (GO:0048167) | 3.59427437 |
| 48 | C4-dicarboxylate transport (GO:0015740) | 3.50970101 |
| 49 | layer formation in cerebral cortex (GO:0021819) | 3.50243400 |
| 50 | auditory behavior (GO:0031223) | 3.50128492 |
| 51 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.48802252 |
| 52 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.43543474 |
| 53 | axonal fasciculation (GO:0007413) | 3.39368922 |
| 54 | axon ensheathment in central nervous system (GO:0032291) | 3.36564912 |
| 55 | central nervous system myelination (GO:0022010) | 3.36564912 |
| 56 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.35182475 |
| 57 | startle response (GO:0001964) | 3.28470354 |
| 58 | dendrite morphogenesis (GO:0048813) | 3.27106147 |
| 59 | neuronal ion channel clustering (GO:0045161) | 3.27039400 |
| 60 | response to auditory stimulus (GO:0010996) | 3.24097270 |
| 61 | amino acid import (GO:0043090) | 3.22250752 |
| 62 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.22218768 |
| 63 | neurotransmitter transport (GO:0006836) | 3.21812736 |
| 64 | negative regulation of neurotransmitter transport (GO:0051589) | 3.19853361 |
| 65 | central nervous system projection neuron axonogenesis (GO:0021952) | 3.19638380 |
| 66 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.19042015 |
| 67 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.18446622 |
| 68 | regulation of dendritic spine development (GO:0060998) | 3.17521424 |
| 69 | neuromuscular process controlling balance (GO:0050885) | 3.16723636 |
| 70 | cellular potassium ion homeostasis (GO:0030007) | 3.15875835 |
| 71 | learning (GO:0007612) | 3.15208401 |
| 72 | positive regulation of synapse maturation (GO:0090129) | 3.14637411 |
| 73 | regulation of neurotransmitter secretion (GO:0046928) | 3.13117773 |
| 74 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.11668822 |
| 75 | positive regulation of synapse assembly (GO:0051965) | 3.09139216 |
| 76 | mechanosensory behavior (GO:0007638) | 3.09010601 |
| 77 | dendritic spine organization (GO:0097061) | 3.08518011 |
| 78 | neurotransmitter uptake (GO:0001504) | 3.08210615 |
| 79 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.07642895 |
| 80 | response to histamine (GO:0034776) | 3.06191735 |
| 81 | membrane depolarization (GO:0051899) | 3.06110405 |
| 82 | adult walking behavior (GO:0007628) | 3.03607986 |
| 83 | membrane hyperpolarization (GO:0060081) | 3.03368652 |
| 84 | serotonin metabolic process (GO:0042428) | 3.02570489 |
| 85 | synapse assembly (GO:0007416) | 2.99936182 |
| 86 | regulation of neurotransmitter levels (GO:0001505) | 2.98365788 |
| 87 | regulation of neurotransmitter transport (GO:0051588) | 2.97803285 |
| 88 | behavioral defense response (GO:0002209) | 2.97398383 |
| 89 | behavioral fear response (GO:0001662) | 2.97398383 |
| 90 | positive regulation of synaptic transmission (GO:0050806) | 2.96006743 |
| 91 | regulation of vesicle fusion (GO:0031338) | 2.95608196 |
| 92 | cerebellar granule cell differentiation (GO:0021707) | 2.95241716 |
| 93 | synaptic vesicle endocytosis (GO:0048488) | 2.95042548 |
| 94 | behavioral response to cocaine (GO:0048148) | 2.94786512 |
| 95 | G-protein coupled acetylcholine receptor signaling pathway (GO:0007213) | 2.94737827 |
| 96 | regulation of synaptic transmission (GO:0050804) | 2.93774525 |
| 97 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.92850081 |
| 98 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.92513003 |
| 99 | positive regulation of dendritic spine development (GO:0060999) | 2.92035701 |
| 100 | regulation of glutamate secretion (GO:0014048) | 2.90524744 |
| 101 | proline transport (GO:0015824) | 2.90066331 |
| 102 | prepulse inhibition (GO:0060134) | 2.89791789 |
| 103 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.88528103 |
| 104 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.87125841 |
| 105 | innervation (GO:0060384) | 2.86337800 |
| 106 | activation of protein kinase A activity (GO:0034199) | 2.86165557 |
| 107 | synapse organization (GO:0050808) | 2.86017336 |
| 108 | positive regulation of neurotransmitter transport (GO:0051590) | 2.85814088 |
| 109 | synaptic transmission (GO:0007268) | 2.83371395 |
| 110 | apical protein localization (GO:0045176) | 2.77245142 |
| 111 | negative regulation of translation, ncRNA-mediated (GO:0040033) | 2.77157206 |
| 112 | regulation of translation, ncRNA-mediated (GO:0045974) | 2.77157206 |
| 113 | negative regulation of translation involved in gene silencing by miRNA (GO:0035278) | 2.77157206 |
| 114 | regulation of gene silencing by RNA (GO:0060966) | 2.75490213 |
| 115 | regulation of posttranscriptional gene silencing (GO:0060147) | 2.75490213 |
| 116 | regulation of gene silencing by miRNA (GO:0060964) | 2.75490213 |
| 117 | atrial cardiac muscle cell action potential (GO:0086014) | 2.73851835 |
| 118 | membrane assembly (GO:0071709) | 2.72492299 |
| 119 | acidic amino acid transport (GO:0015800) | 2.71793931 |
| 120 | cell migration in hindbrain (GO:0021535) | 2.71674839 |
| 121 | membrane depolarization during action potential (GO:0086010) | 2.67510945 |
| 122 | social behavior (GO:0035176) | 2.62975746 |
| 123 | intraspecies interaction between organisms (GO:0051703) | 2.62975746 |
| 124 | retinal cone cell development (GO:0046549) | 2.62104793 |
| 125 | cellular response to cholesterol (GO:0071397) | 2.61108586 |
| 126 | cerebellar Purkinje cell layer development (GO:0021680) | 2.59120227 |
| 127 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.58372957 |
| 128 | establishment of mitochondrion localization (GO:0051654) | 2.57875795 |
| 129 | regulation of synapse assembly (GO:0051963) | 2.56047919 |
| 130 | negative regulation of dendrite development (GO:2000171) | 2.55811257 |
| 131 | cochlea development (GO:0090102) | 2.54807281 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.72617437 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.92327724 |
| 3 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.09493436 |
| 4 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.04279385 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.98593621 |
| 6 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.59071274 |
| 7 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.59071274 |
| 8 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.57172445 |
| 9 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.51367723 |
| 10 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.46874046 |
| 11 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.46683689 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.44112905 |
| 13 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.43990960 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.43819136 |
| 15 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.43722966 |
| 16 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.39765247 |
| 17 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 2.38855968 |
| 18 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 2.30837747 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.26841253 |
| 20 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 2.23385173 |
| 21 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.15125405 |
| 22 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.14008655 |
| 23 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.13604405 |
| 24 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.13266227 |
| 25 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.02390450 |
| 26 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.96403675 |
| 27 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.93423194 |
| 28 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.90293085 |
| 29 | * CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.87682362 |
| 30 | * SMAD4_21799915_ChIP-Seq_A2780_Human | 1.70642918 |
| 31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.70171171 |
| 32 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.69807365 |
| 33 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.66475689 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.66206268 |
| 35 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.65135398 |
| 36 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.60998710 |
| 37 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.60073610 |
| 38 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.58026832 |
| 39 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.56901545 |
| 40 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.55964169 |
| 41 | P300_19829295_ChIP-Seq_ESCs_Human | 1.53318522 |
| 42 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.52459172 |
| 43 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.51819094 |
| 44 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.51058677 |
| 45 | EWS_26573619_Chip-Seq_HEK293_Human | 1.49835313 |
| 46 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.49799549 |
| 47 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.46437403 |
| 48 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.45993510 |
| 49 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.45106142 |
| 50 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.44958516 |
| 51 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.38018978 |
| 52 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.37421760 |
| 53 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.36086371 |
| 54 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.35931622 |
| 55 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.32525026 |
| 56 | * STAT3_23295773_ChIP-Seq_U87_Human | 1.32414841 |
| 57 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.29469087 |
| 58 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.28874465 |
| 59 | STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse | 1.28704005 |
| 60 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.28702001 |
| 61 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.28128639 |
| 62 | FUS_26573619_Chip-Seq_HEK293_Human | 1.27421788 |
| 63 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.27410773 |
| 64 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.26485207 |
| 65 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.25693630 |
| 66 | AR_25329375_ChIP-Seq_VCAP_Human | 1.24145775 |
| 67 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.23514683 |
| 68 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.23021771 |
| 69 | * NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.22158881 |
| 70 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.21006975 |
| 71 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.20444856 |
| 72 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.20425504 |
| 73 | TRIM28_17542650_ChIP-ChIP_NTERA2_Human | 1.20181056 |
| 74 | TCF4_23295773_ChIP-Seq_U87_Human | 1.19425234 |
| 75 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.18671722 |
| 76 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.17977194 |
| 77 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.17307702 |
| 78 | TBX3_20139965_ChIP-Seq_MESCs_Mouse | 1.17076236 |
| 79 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.16908579 |
| 80 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.16265830 |
| 81 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.16216351 |
| 82 | TBX3_20139965_ChIP-Seq_ESCs_Mouse | 1.15949041 |
| 83 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.15844327 |
| 84 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.15745689 |
| 85 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.15676536 |
| 86 | * AR_19668381_ChIP-Seq_PC3_Human | 1.13088100 |
| 87 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.12926197 |
| 88 | * ER_23166858_ChIP-Seq_MCF-7_Human | 1.11178391 |
| 89 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.11022391 |
| 90 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.10601139 |
| 91 | * PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.10009445 |
| 92 | TP53_16413492_ChIP-PET_HCT116_Human | 1.09635398 |
| 93 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.09141908 |
| 94 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.08541210 |
| 95 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.07374240 |
| 96 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.06648326 |
| 97 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.06648326 |
| 98 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.06541476 |
| 99 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.06411312 |
| 100 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.06304789 |
| 101 | KDM2B_26808549_Chip-Seq_REH_Human | 1.05863070 |
| 102 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.05623467 |
| 103 | POU5F1_18347094_ChIP-ChIP_MESCs_Mouse | 1.05572016 |
| 104 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.05275437 |
| 105 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.05037902 |
| 106 | VDR_22108803_ChIP-Seq_LS180_Human | 1.04947912 |
| 107 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 1.04685555 |
| 108 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.04034638 |
| 109 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.02392695 |
| 110 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.02092345 |
| 111 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 0.99966495 |
| 112 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.97311675 |
| 113 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.97311675 |
| 114 | TP53_18474530_ChIP-ChIP_U2OS_Human | 0.94940977 |
| 115 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.94404310 |
| 116 | * JUN_21703547_ChIP-Seq_K562_Human | 0.93366289 |
| 117 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.92107669 |
| 118 | * SMAD3_21741376_ChIP-Seq_HESCs_Human | 0.91076828 |
| 119 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.91043567 |
| 120 | * TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.90707530 |
| 121 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.90392689 |
| 122 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.89483454 |
| 123 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.88581053 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 6.28190806 |
| 2 | MP0003880_abnormal_central_pattern | 5.36040236 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 4.06174033 |
| 4 | MP0004270_analgesia | 3.78397440 |
| 5 | MP0009745_abnormal_behavioral_response | 3.49843832 |
| 6 | MP0002064_seizures | 3.28152448 |
| 7 | MP0002063_abnormal_learning/memory/cond | 3.26754568 |
| 8 | MP0002822_catalepsy | 3.02989270 |
| 9 | MP0009046_muscle_twitch | 2.95057117 |
| 10 | MP0002572_abnormal_emotion/affect_behav | 2.81989117 |
| 11 | MP0001486_abnormal_startle_reflex | 2.79927134 |
| 12 | MP0002272_abnormal_nervous_system | 2.69877245 |
| 13 | MP0001968_abnormal_touch/_nociception | 2.67427400 |
| 14 | MP0005423_abnormal_somatic_nervous | 2.65837945 |
| 15 | MP0002734_abnormal_mechanical_nocicepti | 2.45325424 |
| 16 | MP0003890_abnormal_embryonic-extraembry | 2.34198732 |
| 17 | MP0006292_abnormal_olfactory_placode | 2.20382087 |
| 18 | MP0001501_abnormal_sleep_pattern | 2.19628935 |
| 19 | MP0001440_abnormal_grooming_behavior | 2.14831369 |
| 20 | MP0002736_abnormal_nociception_after | 2.08145086 |
| 21 | MP0000778_abnormal_nervous_system | 2.04970612 |
| 22 | MP0002735_abnormal_chemical_nociception | 2.01752989 |
| 23 | MP0003329_amyloid_beta_deposits | 1.99108615 |
| 24 | MP0009780_abnormal_chondrocyte_physiolo | 1.95526726 |
| 25 | MP0005646_abnormal_pituitary_gland | 1.92375225 |
| 26 | MP0001529_abnormal_vocalization | 1.91225729 |
| 27 | MP0002067_abnormal_sensory_capabilities | 1.91132686 |
| 28 | MP0002733_abnormal_thermal_nociception | 1.87628562 |
| 29 | MP0001970_abnormal_pain_threshold | 1.87563482 |
| 30 | MP0008877_abnormal_DNA_methylation | 1.81296067 |
| 31 | MP0008569_lethality_at_weaning | 1.74457894 |
| 32 | MP0005386_behavior/neurological_phenoty | 1.71293048 |
| 33 | MP0004924_abnormal_behavior | 1.71293048 |
| 34 | MP0000920_abnormal_myelination | 1.68409085 |
| 35 | MP0002557_abnormal_social/conspecific_i | 1.66906496 |
| 36 | MP0001905_abnormal_dopamine_level | 1.66732282 |
| 37 | MP0004885_abnormal_endolymph | 1.65222491 |
| 38 | MP0003121_genomic_imprinting | 1.63461599 |
| 39 | MP0002184_abnormal_innervation | 1.62208499 |
| 40 | MP0004811_abnormal_neuron_physiology | 1.56146065 |
| 41 | MP0000955_abnormal_spinal_cord | 1.55682102 |
| 42 | MP0001984_abnormal_olfaction | 1.50905625 |
| 43 | MP0003119_abnormal_digestive_system | 1.46430676 |
| 44 | MP0002882_abnormal_neuron_morphology | 1.46300607 |
| 45 | MP0000566_synostosis | 1.45031616 |
| 46 | MP0002066_abnormal_motor_capabilities/c | 1.44762975 |
| 47 | MP0002909_abnormal_adrenal_gland | 1.43456950 |
| 48 | MP0004142_abnormal_muscle_tone | 1.42579114 |
| 49 | MP0004858_abnormal_nervous_system | 1.39694058 |
| 50 | MP0003879_abnormal_hair_cell | 1.38063986 |
| 51 | MP0003690_abnormal_glial_cell | 1.37458188 |
| 52 | MP0003633_abnormal_nervous_system | 1.36265540 |
| 53 | MP0005645_abnormal_hypothalamus_physiol | 1.28570643 |
| 54 | MP0004133_heterotaxia | 1.28382680 |
| 55 | MP0004742_abnormal_vestibular_system | 1.25949946 |
| 56 | MP0006276_abnormal_autonomic_nervous | 1.24661514 |
| 57 | MP0000569_abnormal_digit_pigmentation | 1.24456584 |
| 58 | MP0003631_nervous_system_phenotype | 1.23925289 |
| 59 | MP0003787_abnormal_imprinting | 1.22697561 |
| 60 | MP0001293_anophthalmia | 1.20644407 |
| 61 | MP0003937_abnormal_limbs/digits/tail_de | 1.20380312 |
| 62 | MP0008789_abnormal_olfactory_epithelium | 1.17003939 |
| 63 | MP0003634_abnormal_glial_cell | 1.16989920 |
| 64 | MP0005409_darkened_coat_color | 1.16573763 |
| 65 | MP0006072_abnormal_retinal_apoptosis | 1.14518039 |
| 66 | MP0001502_abnormal_circadian_rhythm | 1.14203295 |
| 67 | MP0001188_hyperpigmentation | 1.14127220 |
| 68 | MP0005187_abnormal_penis_morphology | 1.13630880 |
| 69 | MP0002152_abnormal_brain_morphology | 1.12782830 |
| 70 | MP0001485_abnormal_pinna_reflex | 1.11988583 |
| 71 | MP0002229_neurodegeneration | 1.10582377 |
| 72 | MP0000049_abnormal_middle_ear | 1.08113439 |
| 73 | MP0002233_abnormal_nose_morphology | 1.05861490 |
| 74 | MP0003632_abnormal_nervous_system | 1.04422154 |
| 75 | MP0005171_absent_coat_pigmentation | 1.03897828 |
| 76 | MP0001177_atelectasis | 1.01945680 |
| 77 | MP0002638_abnormal_pupillary_reflex | 1.01721847 |
| 78 | MP0002102_abnormal_ear_morphology | 1.00292920 |
| 79 | MP0005551_abnormal_eye_electrophysiolog | 0.99529104 |
| 80 | MP0003123_paternal_imprinting | 0.98445891 |
| 81 | MP0002938_white_spotting | 0.96879099 |
| 82 | MP0001963_abnormal_hearing_physiology | 0.96737802 |
| 83 | MP0004145_abnormal_muscle_electrophysio | 0.96438786 |
| 84 | MP0000579_abnormal_nail_morphology | 0.96316935 |
| 85 | MP0005253_abnormal_eye_physiology | 0.94699989 |
| 86 | MP0002751_abnormal_autonomic_nervous | 0.90704714 |
| 87 | MP0000631_abnormal_neuroendocrine_gland | 0.90452065 |
| 88 | MP0002069_abnormal_eating/drinking_beha | 0.89677167 |
| 89 | MP0000604_amyloidosis | 0.89209259 |
| 90 | MP0005248_abnormal_Harderian_gland | 0.88840970 |
| 91 | MP0003941_abnormal_skin_development | 0.85833281 |
| 92 | MP0008874_decreased_physiological_sensi | 0.84948919 |
| 93 | MP0008872_abnormal_physiological_respon | 0.84623583 |
| 94 | MP0000428_abnormal_craniofacial_morphol | 0.82763607 |
| 95 | MP0002752_abnormal_somatic_nervous | 0.81461415 |
| 96 | MP0003122_maternal_imprinting | 0.81298926 |
| 97 | MP0000013_abnormal_adipose_tissue | 0.81295882 |
| 98 | MP0004043_abnormal_pH_regulation | 0.80867358 |
| 99 | MP0004085_abnormal_heartbeat | 0.79567951 |
| 100 | MP0000751_myopathy | 0.79409316 |
| 101 | MP0003718_maternal_effect | 0.78890994 |
| 102 | MP0003075_altered_response_to | 0.78344082 |
| 103 | MP0002697_abnormal_eye_size | 0.78078458 |
| 104 | MP0002234_abnormal_pharynx_morphology | 0.78070273 |
| 105 | MP0003755_abnormal_palate_morphology | 0.77997177 |
| 106 | MP0002081_perinatal_lethality | 0.76955063 |
| 107 | MP0005535_abnormal_body_temperature | 0.74277922 |
| 108 | MP0002090_abnormal_vision | 0.74020144 |
| 109 | MP0003567_abnormal_fetal_cardiomyocyte | 0.71633935 |
| 110 | MP0005195_abnormal_posterior_eye | 0.71586421 |
| 111 | MP0010386_abnormal_urinary_bladder | 0.70055011 |
| 112 | MP0002837_dystrophic_cardiac_calcinosis | 0.69889229 |
| 113 | MP0001664_abnormal_digestion | 0.69231766 |
| 114 | MP0003172_abnormal_lysosome_physiology | 0.69164323 |
| 115 | MP0005394_taste/olfaction_phenotype | 0.66587898 |
| 116 | MP0005499_abnormal_olfactory_system | 0.66587898 |
| 117 | MP0003137_abnormal_impulse_conducting | 0.62604708 |
| 118 | MP0002876_abnormal_thyroid_physiology | 0.60400000 |
| 119 | MP0000026_abnormal_inner_ear | 0.59862342 |
| 120 | MP0005623_abnormal_meninges_morphology | 0.59031352 |
| 121 | MP0001299_abnormal_eye_distance/ | 0.58963368 |
| 122 | MP0003283_abnormal_digestive_organ | 0.58914006 |
| 123 | MP0001943_abnormal_respiration | 0.58225793 |
| 124 | MP0003861_abnormal_nervous_system | 0.56319729 |
| 125 | MP0003136_yellow_coat_color | 0.52704935 |
| 126 | MP0010769_abnormal_survival | 0.50229536 |
| 127 | MP0004215_abnormal_myocardial_fiber | 0.50204340 |
| 128 | MP0010770_preweaning_lethality | 0.49470317 |
| 129 | MP0002082_postnatal_lethality | 0.49470317 |
| 130 | MP0005410_abnormal_fertilization | 0.49455829 |
| 131 | MP0004484_altered_response_of | 0.47551990 |
| 132 | MP0003938_abnormal_ear_development | 0.47188778 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 7.95564521 |
| 2 | Myokymia (HP:0002411) | 6.39302215 |
| 3 | Focal seizures (HP:0007359) | 5.52127260 |
| 4 | Epileptic encephalopathy (HP:0200134) | 4.93156597 |
| 5 | Atonic seizures (HP:0010819) | 4.72686750 |
| 6 | Visual hallucinations (HP:0002367) | 4.36444474 |
| 7 | Absence seizures (HP:0002121) | 3.99149804 |
| 8 | Febrile seizures (HP:0002373) | 3.97758581 |
| 9 | Dialeptic seizures (HP:0011146) | 3.90032463 |
| 10 | Progressive cerebellar ataxia (HP:0002073) | 3.87314375 |
| 11 | Hyperventilation (HP:0002883) | 3.84587720 |
| 12 | Hepatoblastoma (HP:0002884) | 3.76812109 |
| 13 | Broad-based gait (HP:0002136) | 3.73822791 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.66171090 |
| 15 | Neurofibrillary tangles (HP:0002185) | 3.62017572 |
| 16 | Supranuclear gaze palsy (HP:0000605) | 3.48181456 |
| 17 | Dysmetria (HP:0001310) | 3.44121007 |
| 18 | Gaze-evoked nystagmus (HP:0000640) | 3.37952009 |
| 19 | Abnormality of the labia minora (HP:0012880) | 3.35329611 |
| 20 | Ankle clonus (HP:0011448) | 3.29077852 |
| 21 | Action tremor (HP:0002345) | 3.28319235 |
| 22 | Cerebral inclusion bodies (HP:0100314) | 3.25406642 |
| 23 | Colon cancer (HP:0003003) | 3.14294956 |
| 24 | Dysdiadochokinesis (HP:0002075) | 3.11518573 |
| 25 | Impaired vibration sensation in the lower limbs (HP:0002166) | 3.07603507 |
| 26 | Truncal ataxia (HP:0002078) | 3.07445399 |
| 27 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 3.05989598 |
| 28 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 3.05989598 |
| 29 | Septo-optic dysplasia (HP:0100842) | 3.01177622 |
| 30 | Scanning speech (HP:0002168) | 2.98391779 |
| 31 | Poor eye contact (HP:0000817) | 2.96070309 |
| 32 | Abnormality of the corticospinal tract (HP:0002492) | 2.95853503 |
| 33 | Spastic gait (HP:0002064) | 2.94745972 |
| 34 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.94255908 |
| 35 | Anxiety (HP:0000739) | 2.84471756 |
| 36 | Excessive salivation (HP:0003781) | 2.82972007 |
| 37 | Drooling (HP:0002307) | 2.82972007 |
| 38 | Amblyopia (HP:0000646) | 2.82893832 |
| 39 | Intention tremor (HP:0002080) | 2.78229070 |
| 40 | Progressive inability to walk (HP:0002505) | 2.75814942 |
| 41 | Abnormal eating behavior (HP:0100738) | 2.72664267 |
| 42 | Depression (HP:0000716) | 2.71012900 |
| 43 | Insidious onset (HP:0003587) | 2.70954519 |
| 44 | Termporal pattern (HP:0011008) | 2.70954519 |
| 45 | Postural instability (HP:0002172) | 2.70930989 |
| 46 | Impaired social interactions (HP:0000735) | 2.70913960 |
| 47 | Abnormal social behavior (HP:0012433) | 2.70913960 |
| 48 | Epileptiform EEG discharges (HP:0011182) | 2.70245776 |
| 49 | Hemiparesis (HP:0001269) | 2.69973753 |
| 50 | Absent speech (HP:0001344) | 2.69737902 |
| 51 | Megalencephaly (HP:0001355) | 2.64318531 |
| 52 | Urinary urgency (HP:0000012) | 2.48769236 |
| 53 | EEG with generalized epileptiform discharges (HP:0011198) | 2.47599929 |
| 54 | Genetic anticipation (HP:0003743) | 2.47088750 |
| 55 | Neoplasm of the adrenal cortex (HP:0100641) | 2.46771319 |
| 56 | Optic nerve hypoplasia (HP:0000609) | 2.45856193 |
| 57 | Amyotrophic lateral sclerosis (HP:0007354) | 2.45185801 |
| 58 | Generalized myoclonic seizures (HP:0002123) | 2.42553609 |
| 59 | Lower limb muscle weakness (HP:0007340) | 2.39994329 |
| 60 | Papilledema (HP:0001085) | 2.39847679 |
| 61 | Diplopia (HP:0000651) | 2.39695255 |
| 62 | Abnormality of binocular vision (HP:0011514) | 2.39695255 |
| 63 | Hypsarrhythmia (HP:0002521) | 2.34912992 |
| 64 | Mutism (HP:0002300) | 2.32954087 |
| 65 | Pheochromocytoma (HP:0002666) | 2.31982744 |
| 66 | Fetal akinesia sequence (HP:0001989) | 2.31098174 |
| 67 | Retinal dysplasia (HP:0007973) | 2.31061371 |
| 68 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 2.30752624 |
| 69 | Blue irides (HP:0000635) | 2.29962700 |
| 70 | Intestinal atresia (HP:0011100) | 2.29591715 |
| 71 | Split foot (HP:0001839) | 2.29055809 |
| 72 | Increased circulating renin level (HP:0000848) | 2.26455319 |
| 73 | Torticollis (HP:0000473) | 2.25592992 |
| 74 | Stereotypic behavior (HP:0000733) | 2.25142490 |
| 75 | Limb dystonia (HP:0002451) | 2.23903668 |
| 76 | Impaired smooth pursuit (HP:0007772) | 2.18910964 |
| 77 | Inability to walk (HP:0002540) | 2.18371450 |
| 78 | Bradykinesia (HP:0002067) | 2.18305107 |
| 79 | Peripheral hypomyelination (HP:0007182) | 2.17384443 |
| 80 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.15292840 |
| 81 | Focal dystonia (HP:0004373) | 2.14409504 |
| 82 | Agnosia (HP:0010524) | 2.10699415 |
| 83 | Impaired vibratory sensation (HP:0002495) | 2.08011532 |
| 84 | Clumsiness (HP:0002312) | 2.06601283 |
| 85 | Medulloblastoma (HP:0002885) | 2.06556545 |
| 86 | Oligodactyly (hands) (HP:0001180) | 2.06382354 |
| 87 | Thickened helices (HP:0000391) | 2.04058776 |
| 88 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.03642784 |
| 89 | Absent/shortened dynein arms (HP:0200106) | 2.03642784 |
| 90 | Hemiplegia (HP:0002301) | 2.02920138 |
| 91 | Cortical dysplasia (HP:0002539) | 2.02840484 |
| 92 | Gait imbalance (HP:0002141) | 2.01562562 |
| 93 | Polyphagia (HP:0002591) | 2.01516709 |
| 94 | Neoplasm of the oral cavity (HP:0100649) | 2.00642899 |
| 95 | Akinesia (HP:0002304) | 1.99965584 |
| 96 | Abnormality of salivation (HP:0100755) | 1.99126152 |
| 97 | Neuroendocrine neoplasm (HP:0100634) | 1.95606376 |
| 98 | Widely spaced teeth (HP:0000687) | 1.94765067 |
| 99 | Aplasia involving bones of the extremities (HP:0009825) | 1.93613970 |
| 100 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.93613970 |
| 101 | Aplasia of the phalanges of the hand (HP:0009802) | 1.93613970 |
| 102 | Abnormality of the astrocytes (HP:0100707) | 1.92560443 |
| 103 | Astrocytoma (HP:0009592) | 1.92560443 |
| 104 | Sleep apnea (HP:0010535) | 1.91648106 |
| 105 | Volvulus (HP:0002580) | 1.91563099 |
| 106 | Cutaneous finger syndactyly (HP:0010554) | 1.91163032 |
| 107 | Glioma (HP:0009733) | 1.90269008 |
| 108 | Aqueductal stenosis (HP:0002410) | 1.89681712 |
| 109 | Gait ataxia (HP:0002066) | 1.87990982 |
| 110 | Specific learning disability (HP:0001328) | 1.87801683 |
| 111 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.86094013 |
| 112 | Craniofacial dystonia (HP:0012179) | 1.85598775 |
| 113 | Protruding tongue (HP:0010808) | 1.85199477 |
| 114 | Genital tract atresia (HP:0001827) | 1.83258390 |
| 115 | Clonus (HP:0002169) | 1.81849571 |
| 116 | Sensory axonal neuropathy (HP:0003390) | 1.81614216 |
| 117 | Preaxial foot polydactyly (HP:0001841) | 1.80940092 |
| 118 | Gastrointestinal atresia (HP:0002589) | 1.80897473 |
| 119 | Gastroesophageal reflux (HP:0002020) | 1.78891966 |
| 120 | Abnormality of the lower motor neuron (HP:0002366) | 1.78582746 |
| 121 | Oligodactyly (HP:0012165) | 1.77946354 |
| 122 | Neuronal loss in central nervous system (HP:0002529) | 1.77139361 |
| 123 | Incomplete penetrance (HP:0003829) | 1.77139349 |
| 124 | Absent septum pellucidum (HP:0001331) | 1.76810179 |
| 125 | Type II lissencephaly (HP:0007260) | 1.76395282 |
| 126 | Lissencephaly (HP:0001339) | 1.74726216 |
| 127 | Renal hypoplasia (HP:0000089) | 1.74519269 |
| 128 | Anophthalmia (HP:0000528) | 1.74489789 |
| 129 | Abnormality of the diencephalon (HP:0010662) | 1.74404552 |
| 130 | Psychosis (HP:0000709) | 1.74151216 |
| 131 | Status epilepticus (HP:0002133) | 1.73527590 |
| 132 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 1.72764448 |
| 133 | Abnormality of saccadic eye movements (HP:0000570) | 1.72595772 |
| 134 | Cutaneous syndactyly (HP:0012725) | 1.72502996 |
| 135 | Rigidity (HP:0002063) | 1.71359907 |
| 136 | Vaginal atresia (HP:0000148) | 1.70529213 |
| 137 | Abnormal lung lobation (HP:0002101) | 1.68083576 |
| 138 | Congenital primary aphakia (HP:0007707) | 1.68007370 |
| 139 | Birth length less than 3rd percentile (HP:0003561) | 1.67091994 |
| 140 | Abnormality of the septum pellucidum (HP:0007375) | 1.65537101 |
| 141 | Growth hormone deficiency (HP:0000824) | 1.63641256 |
| 142 | Scrotal hypoplasia (HP:0000046) | 1.63149998 |
| 143 | Spastic tetraplegia (HP:0002510) | 1.62709946 |
| 144 | Papillary thyroid carcinoma (HP:0002895) | 1.62292185 |
| 145 | Inappropriate behavior (HP:0000719) | 1.55728748 |
| 146 | Labial hypoplasia (HP:0000066) | 1.55525760 |
| 147 | Hyperglycinemia (HP:0002154) | 1.55522450 |
| 148 | Bronchomalacia (HP:0002780) | 1.53865163 |
| 149 | Bilateral microphthalmos (HP:0007633) | 1.53822370 |
| 150 | Stomach cancer (HP:0012126) | 1.53238220 |
| 151 | Bifid tongue (HP:0010297) | 1.52731432 |
| 152 | Neoplasm of the adrenal gland (HP:0100631) | 1.52616191 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 5.11912050 |
| 2 | NTRK3 | 4.31654370 |
| 3 | MAP3K9 | 2.98711677 |
| 4 | CASK | 2.74133862 |
| 5 | MAP3K4 | 2.59234546 |
| 6 | MARK1 | 2.55233674 |
| 7 | TNIK | 2.40038974 |
| 8 | MKNK2 | 2.34813289 |
| 9 | MAP2K7 | 2.20258887 |
| 10 | DAPK2 | 2.17071759 |
| 11 | MINK1 | 2.14286975 |
| 12 | NTRK2 | 2.08601403 |
| 13 | NTRK1 | 2.04719573 |
| 14 | PAK6 | 2.03401670 |
| 15 | DYRK2 | 2.01315415 |
| 16 | RIPK4 | 1.87199499 |
| 17 | PRKD3 | 1.81446632 |
| 18 | OXSR1 | 1.79412677 |
| 19 | PNCK | 1.78368788 |
| 20 | CDK19 | 1.76681918 |
| 21 | PRPF4B | 1.72741156 |
| 22 | FES | 1.71349006 |
| 23 | KSR2 | 1.71226908 |
| 24 | TYRO3 | 1.61043563 |
| 25 | CDK5 | 1.58819020 |
| 26 | MAP3K12 | 1.56046489 |
| 27 | MAP2K4 | 1.53772194 |
| 28 | TRIM28 | 1.53662597 |
| 29 | STK39 | 1.50985955 |
| 30 | MKNK1 | 1.50728187 |
| 31 | FRK | 1.48808167 |
| 32 | PLK2 | 1.45426656 |
| 33 | CSNK1G1 | 1.45417492 |
| 34 | MAPK13 | 1.42332090 |
| 35 | BMPR1B | 1.39053025 |
| 36 | TSSK6 | 1.37619685 |
| 37 | KSR1 | 1.36500645 |
| 38 | DAPK1 | 1.35068062 |
| 39 | CAMKK1 | 1.30069115 |
| 40 | CAMK2B | 1.28349705 |
| 41 | CDC7 | 1.26131290 |
| 42 | UHMK1 | 1.18911150 |
| 43 | CAMK2A | 1.18644127 |
| 44 | ARAF | 1.18298311 |
| 45 | PRKCG | 1.12042738 |
| 46 | GRK5 | 1.10983956 |
| 47 | MAP3K2 | 1.10801865 |
| 48 | PLK3 | 1.10377637 |
| 49 | TAF1 | 1.06165473 |
| 50 | BMPR2 | 1.03353884 |
| 51 | SGK223 | 1.01071569 |
| 52 | SGK494 | 1.01071569 |
| 53 | MAP3K13 | 1.00563875 |
| 54 | ACVR1B | 0.99515263 |
| 55 | CSNK1G2 | 0.96973070 |
| 56 | SIK2 | 0.95988905 |
| 57 | ZAK | 0.95414044 |
| 58 | LATS2 | 0.92931703 |
| 59 | MARK2 | 0.90090729 |
| 60 | NEK6 | 0.89545943 |
| 61 | CDK18 | 0.89437786 |
| 62 | CDK15 | 0.88349928 |
| 63 | MAP4K2 | 0.88087786 |
| 64 | CDK14 | 0.86924117 |
| 65 | PTK2B | 0.85398940 |
| 66 | FGR | 0.84762511 |
| 67 | STK11 | 0.83641463 |
| 68 | PHKG2 | 0.83518144 |
| 69 | PHKG1 | 0.83518144 |
| 70 | CAMK2D | 0.79007369 |
| 71 | PAK3 | 0.78291692 |
| 72 | CDK11A | 0.76778054 |
| 73 | CAMKK2 | 0.75883871 |
| 74 | CAMK1 | 0.75405307 |
| 75 | BCR | 0.75321719 |
| 76 | SGK1 | 0.74495427 |
| 77 | PRKCH | 0.73733513 |
| 78 | FGFR2 | 0.72283949 |
| 79 | PKN1 | 0.72030652 |
| 80 | STK38L | 0.70889585 |
| 81 | STK38 | 0.69622572 |
| 82 | CDK3 | 0.67537994 |
| 83 | NME1 | 0.67030557 |
| 84 | RET | 0.66383768 |
| 85 | RAF1 | 0.65858719 |
| 86 | PDPK1 | 0.65664178 |
| 87 | TTK | 0.65400204 |
| 88 | ERBB3 | 0.64126406 |
| 89 | PDK1 | 0.63717132 |
| 90 | PRKCE | 0.63150947 |
| 91 | SGK2 | 0.61922311 |
| 92 | MAPKAPK5 | 0.61729833 |
| 93 | DYRK1A | 0.61531362 |
| 94 | ADRBK2 | 0.60779841 |
| 95 | MUSK | 0.60292390 |
| 96 | WNK4 | 0.59726407 |
| 97 | ROCK2 | 0.59592328 |
| 98 | CAMK2G | 0.59390833 |
| 99 | PINK1 | 0.59380841 |
| 100 | ERBB4 | 0.57539130 |
| 101 | FYN | 0.55417622 |
| 102 | CSNK1D | 0.54810998 |
| 103 | MAP3K10 | 0.54597358 |
| 104 | WNK1 | 0.54577221 |
| 105 | PLK4 | 0.54553074 |
| 106 | CSNK1E | 0.54033172 |
| 107 | TAOK1 | 0.52638612 |
| 108 | ICK | 0.50983648 |
| 109 | CAMK1G | 0.49765005 |
| 110 | YES1 | 0.49042574 |
| 111 | NUAK1 | 0.48671464 |
| 112 | RPS6KA3 | 0.48011737 |
| 113 | EPHB2 | 0.47740400 |
| 114 | VRK1 | 0.46658722 |
| 115 | SRPK1 | 0.45879254 |
| 116 | MAPK15 | 0.45394136 |
| 117 | SGK3 | 0.45188660 |
| 118 | CSNK1G3 | 0.44687439 |
| 119 | PBK | 0.43668123 |
| 120 | MAP3K1 | 0.43401971 |
| 121 | BUB1 | 0.43035831 |
| 122 | PRKDC | 0.42634607 |
| 123 | PRKCZ | 0.42581910 |
| 124 | DMPK | 0.41638675 |
| 125 | PLK1 | 0.41185655 |
| 126 | GRK1 | 0.39419462 |
| 127 | MAPK10 | 0.39311351 |
| 128 | WEE1 | 0.37995609 |
| 129 | PRKCQ | 0.37506851 |
| 130 | WNK3 | 0.36598893 |
| 131 | ALK | 0.35397242 |
| 132 | ROCK1 | 0.35397139 |
| 133 | AKT3 | 0.34334740 |
| 134 | LMTK2 | 0.31993722 |
| 135 | CSNK1A1 | 0.31620319 |
| 136 | CSNK1A1L | 0.31501300 |
| 137 | PRKACA | 0.31196037 |
| 138 | CDC42BPA | 0.30990562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 3.71907384 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.97267914 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.76753918 |
| 4 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.76364177 |
| 5 | GABAergic synapse_Homo sapiens_hsa04727 | 2.76207486 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.70642383 |
| 7 | Long-term potentiation_Homo sapiens_hsa04720 | 2.62507460 |
| 8 | Morphine addiction_Homo sapiens_hsa05032 | 2.59033145 |
| 9 | Olfactory transduction_Homo sapiens_hsa04740 | 2.58237086 |
| 10 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.54871152 |
| 11 | Dopaminergic synapse_Homo sapiens_hsa04728 | 2.22121135 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.17935264 |
| 13 | Insulin secretion_Homo sapiens_hsa04911 | 1.98152783 |
| 14 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.97029496 |
| 15 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.88073480 |
| 16 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.87147824 |
| 17 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.85337426 |
| 18 | Cocaine addiction_Homo sapiens_hsa05030 | 1.83236175 |
| 19 | Long-term depression_Homo sapiens_hsa04730 | 1.78366041 |
| 20 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.71678545 |
| 21 | Taste transduction_Homo sapiens_hsa04742 | 1.71358238 |
| 22 | Renin secretion_Homo sapiens_hsa04924 | 1.70114950 |
| 23 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.65087753 |
| 24 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.61753944 |
| 25 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.59742317 |
| 26 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.58308401 |
| 27 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.55292480 |
| 28 | Axon guidance_Homo sapiens_hsa04360 | 1.38861968 |
| 29 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.35905381 |
| 30 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.31227090 |
| 31 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 1.31202660 |
| 32 | Gap junction_Homo sapiens_hsa04540 | 1.29386929 |
| 33 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.29173023 |
| 34 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.28494210 |
| 35 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.28187575 |
| 36 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.27360201 |
| 37 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.19567734 |
| 38 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.12795324 |
| 39 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 1.12056313 |
| 40 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 1.11938382 |
| 41 | Hippo signaling pathway_Homo sapiens_hsa04390 | 1.11178572 |
| 42 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.08587647 |
| 43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.06745548 |
| 44 | ErbB signaling pathway_Homo sapiens_hsa04012 | 1.05653932 |
| 45 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.04767088 |
| 46 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.03722299 |
| 47 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.03614130 |
| 48 | Glioma_Homo sapiens_hsa05214 | 1.01122431 |
| 49 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.99172107 |
| 50 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.97816277 |
| 51 | Melanogenesis_Homo sapiens_hsa04916 | 0.97568426 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.95962611 |
| 53 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.92150346 |
| 54 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.91724102 |
| 55 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.90733436 |
| 56 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.89235504 |
| 57 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.88996508 |
| 58 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.85894781 |
| 59 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.80003921 |
| 60 | Phototransduction_Homo sapiens_hsa04744 | 0.79102623 |
| 61 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.79008073 |
| 62 | Protein export_Homo sapiens_hsa03060 | 0.78582962 |
| 63 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.77959445 |
| 64 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.76917628 |
| 65 | Basal transcription factors_Homo sapiens_hsa03022 | 0.76007771 |
| 66 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.75852905 |
| 67 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.75678723 |
| 68 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.74129843 |
| 69 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.71848094 |
| 70 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.70648391 |
| 71 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.68786947 |
| 72 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.68498393 |
| 73 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.66694668 |
| 74 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.66049913 |
| 75 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.65196529 |
| 76 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.64898532 |
| 77 | Alzheimers disease_Homo sapiens_hsa05010 | 0.64040351 |
| 78 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.62865360 |
| 79 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.60701131 |
| 80 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.58791041 |
| 81 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.58743158 |
| 82 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.57897168 |
| 83 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.56808812 |
| 84 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.56054485 |
| 85 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.55044684 |
| 86 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.54555865 |
| 87 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.54317470 |
| 88 | Colorectal cancer_Homo sapiens_hsa05210 | 0.53164309 |
| 89 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.52474455 |
| 90 | Alcoholism_Homo sapiens_hsa05034 | 0.52330103 |
| 91 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.51764648 |
| 92 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.51158829 |
| 93 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.50519593 |
| 94 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.50146159 |
| 95 | RNA degradation_Homo sapiens_hsa03018 | 0.49559573 |
| 96 | Prion diseases_Homo sapiens_hsa05020 | 0.49036867 |
| 97 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.48599938 |
| 98 | Endocytosis_Homo sapiens_hsa04144 | 0.48186184 |
| 99 | Histidine metabolism_Homo sapiens_hsa00340 | 0.46933013 |
| 100 | Mismatch repair_Homo sapiens_hsa03430 | 0.45252282 |
| 101 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.44224834 |
| 102 | Huntingtons disease_Homo sapiens_hsa05016 | 0.44107101 |
| 103 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43807371 |
| 104 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.43659360 |
| 105 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.43500615 |
| 106 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.43438346 |
| 107 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.42854230 |
| 108 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.42250630 |
| 109 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.39938754 |
| 110 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.39876417 |
| 111 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.39813580 |
| 112 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.39427183 |
| 113 | Cell cycle_Homo sapiens_hsa04110 | 0.38786421 |
| 114 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.38664877 |
| 115 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.38408894 |
| 116 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.38125382 |
| 117 | Non-homologous end-joining_Homo sapiens_hsa03450 | 0.37997263 |
| 118 | Circadian rhythm_Homo sapiens_hsa04710 | 0.37165882 |
| 119 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.35665606 |
| 120 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.34233188 |
| 121 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.33489234 |
| 122 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.32849968 |
| 123 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.32211542 |
| 124 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.31429994 |
| 125 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.31304714 |
| 126 | Bile secretion_Homo sapiens_hsa04976 | 0.31189089 |
| 127 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.30514658 |
| 128 | Parkinsons disease_Homo sapiens_hsa05012 | 0.29647779 |
| 129 | Tight junction_Homo sapiens_hsa04530 | 0.28510034 |
| 130 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.26610478 |

