TMEM132D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)6.47959634
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.18888285
3synaptic vesicle docking involved in exocytosis (GO:0016081)5.67738550
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.48951154
5synaptic vesicle maturation (GO:0016188)5.47177945
6G-protein coupled glutamate receptor signaling pathway (GO:0007216)5.44702095
7regulation of synaptic vesicle exocytosis (GO:2000300)5.43087469
8vocalization behavior (GO:0071625)5.32260027
9protein localization to synapse (GO:0035418)5.26826654
10glutamate secretion (GO:0014047)5.26684810
11regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.23231447
12detection of light stimulus involved in sensory perception (GO:0050962)5.16087813
13detection of light stimulus involved in visual perception (GO:0050908)5.16087813
14gamma-aminobutyric acid signaling pathway (GO:0007214)5.03596457
15neuron cell-cell adhesion (GO:0007158)5.00040481
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.91252161
17regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.82187603
18glutamate receptor signaling pathway (GO:0007215)4.68750656
19cellular potassium ion homeostasis (GO:0030007)4.67972206
20synaptic vesicle endocytosis (GO:0048488)4.67874277
21regulation of synaptic vesicle transport (GO:1902803)4.64061628
22regulation of glutamate receptor signaling pathway (GO:1900449)4.56490302
23positive regulation of synapse maturation (GO:0090129)4.53726278
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.48990362
25neurotransmitter-gated ion channel clustering (GO:0072578)4.44917849
26locomotory exploration behavior (GO:0035641)4.30489604
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.25301154
28negative regulation of cytosolic calcium ion concentration (GO:0051481)4.20936769
29neurotransmitter secretion (GO:0007269)4.19573021
30neuron-neuron synaptic transmission (GO:0007270)4.15471567
31synaptic transmission, glutamatergic (GO:0035249)4.14589476
32neuronal action potential propagation (GO:0019227)4.08083335
33sodium ion export (GO:0071436)4.06733058
34innervation (GO:0060384)3.91960369
35regulation of neurotransmitter secretion (GO:0046928)3.91183146
36presynaptic membrane assembly (GO:0097105)3.90684881
37long-term synaptic potentiation (GO:0060291)3.89876205
38L-amino acid import (GO:0043092)3.87513197
39retinal rod cell development (GO:0046548)3.86580004
40membrane hyperpolarization (GO:0060081)3.80642938
41positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.80274909
42regulation of synaptic transmission, glutamatergic (GO:0051966)3.79978750
43regulation of synapse maturation (GO:0090128)3.70321110
44response to pheromone (GO:0019236)3.69415835
45regulation of postsynaptic membrane potential (GO:0060078)3.69331139
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67992196
47cerebellar Purkinje cell differentiation (GO:0021702)3.67676611
48positive regulation of membrane potential (GO:0045838)3.67449476
49regulation of neurotransmitter transport (GO:0051588)3.65556860
50regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.64844303
51positive regulation of neurotransmitter secretion (GO:0001956)3.64465349
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62890946
53regulation of neuronal synaptic plasticity (GO:0048168)3.59219801
54neurotransmitter transport (GO:0006836)3.58142264
55cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55466454
56membrane depolarization during action potential (GO:0086010)3.53772209
57relaxation of smooth muscle (GO:0044557)3.53443125
58presynaptic membrane organization (GO:0097090)3.53216567
59potassium ion homeostasis (GO:0055075)3.52620700
60response to histamine (GO:0034776)3.52109412
61exploration behavior (GO:0035640)3.51911776
62long term synaptic depression (GO:0060292)3.50887138
63regulation of long-term neuronal synaptic plasticity (GO:0048169)3.50111531
64positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.49958203
65establishment of synaptic vesicle localization (GO:0097480)3.49857615
66synaptic vesicle transport (GO:0048489)3.49857615
67regulation of voltage-gated calcium channel activity (GO:1901385)3.49156189
68positive regulation of neurotransmitter transport (GO:0051590)3.48524954
69postsynaptic membrane organization (GO:0001941)3.47706822
70striatum development (GO:0021756)3.47436940
71regulation of synapse structural plasticity (GO:0051823)3.45982444
72behavioral response to cocaine (GO:0048148)3.42946315
73layer formation in cerebral cortex (GO:0021819)3.42177660
74startle response (GO:0001964)3.41511847
75proline transport (GO:0015824)3.40027463
76synapse assembly (GO:0007416)3.38059767
77regulation of vesicle fusion (GO:0031338)3.37245500
78negative regulation of synaptic transmission, GABAergic (GO:0032229)3.37165078
79neuron recognition (GO:0008038)3.37038769
80urinary tract smooth muscle contraction (GO:0014848)3.35763339
81amino acid import (GO:0043090)3.33253587
82gamma-aminobutyric acid transport (GO:0015812)3.32235395
83chemosensory behavior (GO:0007635)3.31001404
84long-term memory (GO:0007616)3.30846336
85regulation of synaptic plasticity (GO:0048167)3.29845734
86phosphorelay signal transduction system (GO:0000160)3.28630455
87neuromuscular synaptic transmission (GO:0007274)3.27108521
88suckling behavior (GO:0001967)3.24127356
89neuromuscular process controlling balance (GO:0050885)3.22819284
90calcium ion import (GO:0070509)3.21042772
91neuronal ion channel clustering (GO:0045161)3.20188485
92prepulse inhibition (GO:0060134)3.19842731
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.18858722
94membrane depolarization (GO:0051899)3.18679675
95cerebellar granule cell differentiation (GO:0021707)3.16731862
96cell communication by electrical coupling (GO:0010644)3.15279794
97mating behavior (GO:0007617)3.15159504
98synaptic transmission (GO:0007268)3.14720600
99positive regulation of dendritic spine development (GO:0060999)3.14638360
100response to gravity (GO:0009629)3.13546560
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13480355
102regulation of dendritic spine morphogenesis (GO:0061001)3.13011673
103negative regulation of dendrite morphogenesis (GO:0050774)3.12940010
104righting reflex (GO:0060013)3.12055848
105positive regulation of dendritic spine morphogenesis (GO:0061003)3.11401054
106regulation of neurotransmitter levels (GO:0001505)3.06999755
107learning (GO:0007612)3.06820310
108regulation of calcium ion-dependent exocytosis (GO:0017158)3.05953514
109dendritic spine morphogenesis (GO:0060997)3.04264680
110positive regulation of synaptic transmission (GO:0050806)3.04216888
111adult walking behavior (GO:0007628)2.99069517
112regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.95900294
113regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.95900294
114serotonin metabolic process (GO:0042428)2.95457407
115transmission of nerve impulse (GO:0019226)2.95182921
116regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.95158350
117axonal fasciculation (GO:0007413)2.94500978
118retinal cone cell development (GO:0046549)2.94485038
119neuromuscular process (GO:0050905)2.92731113
120potassium ion import (GO:0010107)2.89531858
121cochlea development (GO:0090102)2.87286779
122social behavior (GO:0035176)2.86281308
123intraspecies interaction between organisms (GO:0051703)2.86281308
124cell migration in hindbrain (GO:0021535)2.85059228
125G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.84845382
126negative regulation of hormone biosynthetic process (GO:0032353)2.82350496
127regulation of synaptic transmission (GO:0050804)2.80107727
128cell differentiation in hindbrain (GO:0021533)2.80037639
129regulation of ARF protein signal transduction (GO:0032012)2.78259900
130response to auditory stimulus (GO:0010996)2.76955381
131auditory behavior (GO:0031223)2.76889258
132dendrite morphogenesis (GO:0048813)2.76391241
133central nervous system projection neuron axonogenesis (GO:0021952)2.74753625

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.67531468
2GBX2_23144817_ChIP-Seq_PC3_Human4.49260127
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95595726
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84595932
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79637047
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.62942193
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.45731524
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.44850765
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44619920
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.41495171
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40805636
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40805636
13* DROSHA_22980978_ChIP-Seq_HELA_Human2.37954422
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.35435473
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.33138074
16ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.32507702
17* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29170643
18AR_21572438_ChIP-Seq_LNCaP_Human2.27239606
19TAF15_26573619_Chip-Seq_HEK293_Human2.26549787
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.21482174
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18763907
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.16420024
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.16180433
24RARB_27405468_Chip-Seq_BRAIN_Mouse2.14108339
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.13586223
26RNF2_27304074_Chip-Seq_ESCs_Mouse2.12387876
27SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.10337257
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.08379037
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.03512205
30REST_18959480_ChIP-ChIP_MESCs_Mouse2.02483128
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.00833445
32SMAD4_21799915_ChIP-Seq_A2780_Human1.89313994
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.88144940
34CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81735612
35IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81008917
36TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.79276259
37* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.74517816
38P300_19829295_ChIP-Seq_ESCs_Human1.74485937
39IGF1R_20145208_ChIP-Seq_DFB_Human1.67837482
40FUS_26573619_Chip-Seq_HEK293_Human1.66132201
41P53_22127205_ChIP-Seq_FIBROBLAST_Human1.56649988
42POU3F2_20337985_ChIP-ChIP_501MEL_Human1.54700156
43NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53459616
44SMAD3_21741376_ChIP-Seq_EPCs_Human1.53278077
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.53214853
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52216669
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.51274121
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.48528975
49AR_25329375_ChIP-Seq_VCAP_Human1.46518669
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40455438
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39077218
52SOX2_21211035_ChIP-Seq_LN229_Gbm1.38550898
53* STAT3_23295773_ChIP-Seq_U87_Human1.36374752
54RNF2_27304074_Chip-Seq_NSC_Mouse1.36344264
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32940622
56RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32476908
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32243960
58EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32163786
59* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31486683
60SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30255943
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.27073784
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.25664334
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.24951730
64* TCF4_23295773_ChIP-Seq_U87_Human1.24761821
65* AR_19668381_ChIP-Seq_PC3_Human1.24410809
66PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19920509
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.19618538
68* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18966599
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18741733
70RING1B_27294783_Chip-Seq_ESCs_Mouse1.18738965
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.18577266
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16825378
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16770181
74ER_23166858_ChIP-Seq_MCF-7_Human1.14193435
75ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12410169
76NANOG_18555785_Chip-Seq_ESCs_Mouse1.12020444
77* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11859158
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11353833
79* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10957660
80VDR_22108803_ChIP-Seq_LS180_Human1.10894616
81AHR_22903824_ChIP-Seq_MCF-7_Human1.09856979
82* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09080298
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.09065944
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.08450531
85* SMAD3_21741376_ChIP-Seq_HESCs_Human1.07789026
86* SMAD3_21741376_ChIP-Seq_ESCs_Human1.04787818
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04701024
88GATA1_26923725_Chip-Seq_HPCs_Mouse1.04318990
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04078861
90* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03861866
91* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02212278
92* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01746379
93* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01238828
94* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01238828
95E2F1_18555785_Chip-Seq_ESCs_Mouse1.00807080
96SOX9_26525672_Chip-Seq_HEART_Mouse1.00736547
97STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00162687
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00079939
99* RUNX2_22187159_ChIP-Seq_PCA_Human0.99178573
100CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.98610438
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97826349
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.97701340
103RING1B_27294783_Chip-Seq_NPCs_Mouse0.97530687
104* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.96737694
105* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.96394748
106TP53_16413492_ChIP-PET_HCT116_Human0.96267231
107KDM2B_26808549_Chip-Seq_REH_Human0.95505417
108* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94920246
109ERG_21242973_ChIP-ChIP_JURKAT_Human0.94709897
110EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.94536040
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.93722456
112CBP_20019798_ChIP-Seq_JUKART_Human0.93616921
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93616921
114EP300_21415370_ChIP-Seq_HL-1_Mouse0.93503630
115HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.92005314
116ISL1_27105846_Chip-Seq_CPCs_Mouse0.91737266
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.91064847
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88351712

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.27634372
2MP0003880_abnormal_central_pattern5.25991195
3MP0003635_abnormal_synaptic_transmissio3.82787364
4MP0005551_abnormal_eye_electrophysiolog3.37334735
5MP0009745_abnormal_behavioral_response3.22729825
6MP0009046_muscle_twitch3.19326116
7MP0002064_seizures3.17510410
8MP0004270_analgesia3.11824805
9MP0002063_abnormal_learning/memory/cond3.10916797
10MP0001968_abnormal_touch/_nociception2.94448836
11MP0001486_abnormal_startle_reflex2.83344485
12MP0005423_abnormal_somatic_nervous2.71127524
13MP0002572_abnormal_emotion/affect_behav2.68032050
14MP0001984_abnormal_olfaction2.65906840
15MP0002272_abnormal_nervous_system2.64423517
16MP0002734_abnormal_mechanical_nocicepti2.55295108
17MP0001501_abnormal_sleep_pattern2.38391040
18MP0002090_abnormal_vision2.29953983
19MP0001502_abnormal_circadian_rhythm2.24437112
20MP0002736_abnormal_nociception_after2.21708247
21MP0002067_abnormal_sensory_capabilities2.11876728
22MP0003283_abnormal_digestive_organ1.98908400
23MP0003879_abnormal_hair_cell1.98747642
24MP0004233_abnormal_muscle_weight1.97382452
25MP0005646_abnormal_pituitary_gland1.91984494
26MP0002184_abnormal_innervation1.87550999
27MP0006072_abnormal_retinal_apoptosis1.80228328
28MP0001188_hyperpigmentation1.78101077
29MP0008569_lethality_at_weaning1.73510002
30MP0002822_catalepsy1.69809311
31MP0001440_abnormal_grooming_behavior1.68412828
32MP0002557_abnormal_social/conspecific_i1.65224053
33MP0001970_abnormal_pain_threshold1.63324823
34MP0002735_abnormal_chemical_nociception1.60791687
35MP0005386_behavior/neurological_phenoty1.55571329
36MP0004924_abnormal_behavior1.55571329
37MP0000778_abnormal_nervous_system1.50594214
38MP0009780_abnormal_chondrocyte_physiolo1.49363357
39MP0004811_abnormal_neuron_physiology1.46841078
40MP0004145_abnormal_muscle_electrophysio1.46603234
41MP0002882_abnormal_neuron_morphology1.46188851
42MP0005253_abnormal_eye_physiology1.45361042
43MP0010386_abnormal_urinary_bladder1.45182309
44MP0008877_abnormal_DNA_methylation1.45151859
45MP0003787_abnormal_imprinting1.41604172
46MP0003121_genomic_imprinting1.38739857
47MP0002733_abnormal_thermal_nociception1.38686139
48MP0000955_abnormal_spinal_cord1.37995276
49MP0003329_amyloid_beta_deposits1.37955861
50MP0001529_abnormal_vocalization1.37347769
51MP0003136_yellow_coat_color1.32767557
52MP0003123_paternal_imprinting1.31534061
53MP0004142_abnormal_muscle_tone1.30706641
54MP0002229_neurodegeneration1.30107099
55MP0002066_abnormal_motor_capabilities/c1.29602208
56MP0003633_abnormal_nervous_system1.25733103
57MP0003890_abnormal_embryonic-extraembry1.24740620
58MP0001346_abnormal_lacrimal_gland1.21840152
59MP0006292_abnormal_olfactory_placode1.20756294
60MP0004858_abnormal_nervous_system1.18805059
61MP0002909_abnormal_adrenal_gland1.18410827
62MP0005195_abnormal_posterior_eye1.17835980
63MP0000569_abnormal_digit_pigmentation1.14963841
64MP0000631_abnormal_neuroendocrine_gland1.14666714
65MP0002752_abnormal_somatic_nervous1.13024582
66MP0004742_abnormal_vestibular_system1.10457979
67MP0006276_abnormal_autonomic_nervous1.09644502
68MP0005248_abnormal_Harderian_gland1.08293293
69MP0004215_abnormal_myocardial_fiber1.07542035
70MP0004133_heterotaxia1.05230082
71MP0003631_nervous_system_phenotype1.04051292
72MP0001177_atelectasis1.03890943
73MP0005394_taste/olfaction_phenotype1.03323497
74MP0005499_abnormal_olfactory_system1.03323497
75MP0002638_abnormal_pupillary_reflex1.02489816
76MP0008004_abnormal_stomach_pH1.01127581
77MP0000751_myopathy0.99997733
78MP0002152_abnormal_brain_morphology0.99685299
79MP0000566_synostosis0.99017229
80MP0001485_abnormal_pinna_reflex0.98842884
81MP0010030_abnormal_orbit_morphology0.97236435
82MP0001905_abnormal_dopamine_level0.97189662
83MP0003938_abnormal_ear_development0.96762953
84MP0001963_abnormal_hearing_physiology0.95200632
85MP0004782_abnormal_surfactant_physiolog0.92462657
86MP0004885_abnormal_endolymph0.90925020
87MP0003861_abnormal_nervous_system0.90671227
88MP0005171_absent_coat_pigmentation0.90532806
89MP0008872_abnormal_physiological_respon0.89558519
90MP0008789_abnormal_olfactory_epithelium0.88827960
91MP0002069_abnormal_eating/drinking_beha0.88082172
92MP0002332_abnormal_exercise_endurance0.87656769
93MP0005645_abnormal_hypothalamus_physiol0.86168869
94MP0004085_abnormal_heartbeat0.85632668
95MP0003690_abnormal_glial_cell0.85106376
96MP0004036_abnormal_muscle_relaxation0.82734290
97MP0003119_abnormal_digestive_system0.78258952
98MP0002234_abnormal_pharynx_morphology0.77515320
99MP0002653_abnormal_ependyma_morphology0.77293698
100MP0003075_altered_response_to0.75921970
101MP0003122_maternal_imprinting0.74106233
102MP0008874_decreased_physiological_sensi0.72968171
103MP0003634_abnormal_glial_cell0.72948034
104MP0008775_abnormal_heart_ventricle0.72678719
105MP0005595_abnormal_vascular_smooth0.72137711
106MP0001664_abnormal_digestion0.67739684
107MP0001944_abnormal_pancreas_morphology0.63330607
108MP0002249_abnormal_larynx_morphology0.63303522
109MP0003632_abnormal_nervous_system0.62399546
110MP0003137_abnormal_impulse_conducting0.61515864
111MP0004043_abnormal_pH_regulation0.61292092
112MP0002751_abnormal_autonomic_nervous0.59808822
113MP0003183_abnormal_peptide_metabolism0.59395945
114MP0002928_abnormal_bile_duct0.58113517
115MP0005409_darkened_coat_color0.57604817
116MP0001943_abnormal_respiration0.57448028
117MP0010769_abnormal_survival0.57359133
118MP0001324_abnormal_eye_pigmentation0.57001407
119MP0002082_postnatal_lethality0.56603367
120MP0010770_preweaning_lethality0.56603367
121MP0000920_abnormal_myelination0.56567895
122MP0002233_abnormal_nose_morphology0.55605893
123MP0004484_altered_response_of0.55331560
124MP0005535_abnormal_body_temperature0.54838339
125MP0000026_abnormal_inner_ear0.54790086
126MP0003950_abnormal_plasma_membrane0.54075026
127MP0005620_abnormal_muscle_contractility0.53932892
128MP0002876_abnormal_thyroid_physiology0.53736990

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)8.56780963
2Focal motor seizures (HP:0011153)7.20687086
3Epileptic encephalopathy (HP:0200134)6.67162320
4Febrile seizures (HP:0002373)5.80335384
5Focal seizures (HP:0007359)4.86878441
6Abnormality of macular pigmentation (HP:0008002)4.64414385
7Central scotoma (HP:0000603)4.63883626
8Absence seizures (HP:0002121)4.47862333
9Myokymia (HP:0002411)4.45365179
10Atonic seizures (HP:0010819)4.44194533
11Severe visual impairment (HP:0001141)4.19710140
12Visual hallucinations (HP:0002367)4.15545653
13Progressive cerebellar ataxia (HP:0002073)4.02409679
14Dialeptic seizures (HP:0011146)3.93319076
15Hyperventilation (HP:0002883)3.87561407
16Generalized tonic-clonic seizures (HP:0002069)3.76003985
17Abnormal rod and cone electroretinograms (HP:0008323)3.68877332
18Gaze-evoked nystagmus (HP:0000640)3.38490796
19Dysdiadochokinesis (HP:0002075)3.17046267
20Broad-based gait (HP:0002136)3.16238876
21Decreased central vision (HP:0007663)3.15408823
22Hemiparesis (HP:0001269)3.14542460
23Limb dystonia (HP:0002451)3.09014474
24Scotoma (HP:0000575)2.96343045
25Epileptiform EEG discharges (HP:0011182)2.95315998
26Septo-optic dysplasia (HP:0100842)2.84575132
27Hepatoblastoma (HP:0002884)2.84380281
28Truncal ataxia (HP:0002078)2.79874195
29EEG with generalized epileptiform discharges (HP:0011198)2.76510094
30Drooling (HP:0002307)2.75150924
31Excessive salivation (HP:0003781)2.75150924
32Absent speech (HP:0001344)2.74805912
33Abnormality of the lower motor neuron (HP:0002366)2.71168023
34Poor eye contact (HP:0000817)2.70286568
35Gait imbalance (HP:0002141)2.70190232
36Scanning speech (HP:0002168)2.64602990
37Aplasia/Hypoplasia of the fovea (HP:0008060)2.59858015
38Hypoplasia of the fovea (HP:0007750)2.59858015
39Mutism (HP:0002300)2.59508200
40Urinary bladder sphincter dysfunction (HP:0002839)2.59305510
41Action tremor (HP:0002345)2.56641551
42Genetic anticipation (HP:0003743)2.54315407
43Annular pancreas (HP:0001734)2.54211213
44Supranuclear gaze palsy (HP:0000605)2.54101186
45Congenital primary aphakia (HP:0007707)2.48657964
46Dysmetria (HP:0001310)2.45886738
47Abnormal social behavior (HP:0012433)2.44878234
48Impaired social interactions (HP:0000735)2.44878234
49Medial flaring of the eyebrow (HP:0010747)2.43161928
50Bony spicule pigmentary retinopathy (HP:0007737)2.42991145
51Impaired smooth pursuit (HP:0007772)2.39957368
52Depression (HP:0000716)2.39778205
53Postural instability (HP:0002172)2.39508310
54Ankle clonus (HP:0011448)2.38460476
55Amblyopia (HP:0000646)2.34831567
56Inability to walk (HP:0002540)2.33214842
57Papilledema (HP:0001085)2.32829429
58Nephrogenic diabetes insipidus (HP:0009806)2.31810952
59Abnormality of the labia minora (HP:0012880)2.31140979
60Hypsarrhythmia (HP:0002521)2.30583804
61Abnormal gallbladder physiology (HP:0012438)2.29735186
62Cholecystitis (HP:0001082)2.29735186
63Craniofacial dystonia (HP:0012179)2.26207900
64Intention tremor (HP:0002080)2.26132423
65Abnormality of the fovea (HP:0000493)2.21575500
66Sleep apnea (HP:0010535)2.19814356
67Fetal akinesia sequence (HP:0001989)2.19576470
68Cerebral inclusion bodies (HP:0100314)2.18857349
69Dysmetric saccades (HP:0000641)2.18013420
70Obstructive sleep apnea (HP:0002870)2.16891331
71Abnormality of binocular vision (HP:0011514)2.16331229
72Diplopia (HP:0000651)2.16331229
73Status epilepticus (HP:0002133)2.15679711
74Protruding tongue (HP:0010808)2.15437138
75Impaired vibration sensation in the lower limbs (HP:0002166)2.13078267
76Abnormal eating behavior (HP:0100738)2.12163722
77Anxiety (HP:0000739)2.11681535
78Clumsiness (HP:0002312)2.11276045
79Oligodactyly (hands) (HP:0001180)2.11098150
80Ventricular fibrillation (HP:0001663)2.08062107
81Abnormality of ocular smooth pursuit (HP:0000617)2.07809919
82Agitation (HP:0000713)2.07713348
83Prolonged QT interval (HP:0001657)2.03803023
84Abnormal hair whorl (HP:0010721)2.03746602
85Torticollis (HP:0000473)2.03248654
86Hemiplegia (HP:0002301)2.00400442
87Generalized myoclonic seizures (HP:0002123)1.99789287
88Stereotypic behavior (HP:0000733)1.98548764
89Bradykinesia (HP:0002067)1.98161418
90Abnormality of the corticospinal tract (HP:0002492)1.96780093
91Poor coordination (HP:0002370)1.95182642
92Specific learning disability (HP:0001328)1.93128644
93Cutaneous finger syndactyly (HP:0010554)1.91924444
94Spastic tetraparesis (HP:0001285)1.90771303
95Urinary urgency (HP:0000012)1.90103413
96Optic nerve hypoplasia (HP:0000609)1.89652128
97Blue irides (HP:0000635)1.88583116
98Congenital sensorineural hearing impairment (HP:0008527)1.85864293
99Attenuation of retinal blood vessels (HP:0007843)1.85552436
100Neurofibrillary tangles (HP:0002185)1.84465089
101Abnormality of salivation (HP:0100755)1.84062323
102Apathy (HP:0000741)1.81804717
103Oligodactyly (HP:0012165)1.81265722
104Genital tract atresia (HP:0001827)1.80086465
105Impaired vibratory sensation (HP:0002495)1.79515419
106Vaginal atresia (HP:0000148)1.78839326
107Progressive inability to walk (HP:0002505)1.78538944
108Papillary thyroid carcinoma (HP:0002895)1.78490980
109Incomplete penetrance (HP:0003829)1.78374632
110Focal dystonia (HP:0004373)1.77889024
111Tetraplegia (HP:0002445)1.77701242
112Heterochromia iridis (HP:0001100)1.76506819
113Thickened helices (HP:0000391)1.76164822
114Akinesia (HP:0002304)1.75546024
115Lower limb muscle weakness (HP:0007340)1.75048550
116Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.74631736
117Spastic gait (HP:0002064)1.74253008
118Polyphagia (HP:0002591)1.74178655
119Unsteady gait (HP:0002317)1.72449622
120Increased circulating renin level (HP:0000848)1.71147405
121Widely spaced teeth (HP:0000687)1.70944233
122Aqueductal stenosis (HP:0002410)1.69435673
123Generalized hypopigmentation (HP:0007513)1.68089435
124Abdominal situs inversus (HP:0003363)1.67824347
125Abnormality of abdominal situs (HP:0011620)1.67824347
126Absent septum pellucidum (HP:0001331)1.67578326
127Bronchomalacia (HP:0002780)1.67525538
128Megalencephaly (HP:0001355)1.67404136
129Abnormal EKG (HP:0003115)1.67372960
130Cutaneous syndactyly (HP:0012725)1.67248995
131Hypoventilation (HP:0002791)1.66543434
132Neoplasm of the oral cavity (HP:0100649)1.64039824
133Morphological abnormality of the pyramidal tract (HP:0002062)1.63685513
134Degeneration of the lateral corticospinal tracts (HP:0002314)1.62899854
135Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62899854
136Turricephaly (HP:0000262)1.60871410
137Mild short stature (HP:0003502)1.60788651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.23961941
2NTRK33.73993720
3CASK3.59691643
4MAP3K43.39389502
5MAP3K93.23752075
6DAPK22.86932611
7PAK62.82644672
8MAP2K72.67605568
9PRPF4B2.42497708
10MINK12.26939972
11MARK12.03053001
12RIPK41.99231281
13CDK191.83240723
14MAP3K121.83057902
15DAPK11.75172135
16MAP2K41.62544221
17PLK21.58682462
18SIK21.58191120
19LATS21.57035557
20KSR11.53408951
21KSR21.52967073
22MAP3K131.51350930
23CCNB11.50660017
24AKT31.49387298
25TNIK1.46460103
26NTRK21.42753620
27STK381.42633833
28CDK51.34192740
29TAOK21.26313798
30NTRK11.25317485
31FES1.24209027
32ARAF1.23867627
33CAMKK11.22357740
34MAPK131.20753051
35TNK21.19079771
36SGK4941.18575755
37SGK2231.18575755
38DYRK1A1.18436455
39OXSR11.16194701
40BMPR21.16148246
41GRK51.15685984
42PRKD31.10523325
43PRKCG1.10467908
44SIK31.09529467
45SGK21.06411911
46FGFR21.06363802
47CSNK1G21.06171234
48CAMK2A1.04224809
49CAMKK21.02357706
50CAMK11.00089204
51PNCK0.96540411
52ALK0.93074753
53BMPR1B0.90977494
54NME10.88039559
55CDK180.86862690
56STK240.85250515
57CDK150.84628371
58PHKG20.84267997
59PHKG10.84267997
60CDK140.81856147
61CDK30.78314181
62RAF10.78259979
63CAMK1G0.78036944
64PTK2B0.77865610
65IRAK20.77015859
66DYRK20.76810747
67SGK10.74504911
68CDK11A0.73826708
69BRSK10.73278596
70CAMK2D0.70886100
71BRAF0.70267931
72TAOK10.70004046
73NEK10.69815435
74SGK30.69480112
75CAMK2B0.68968021
76PAK30.66329595
77PINK10.66096452
78STK110.65334060
79PRKCE0.63285421
80CAMK1D0.62467663
81FRK0.61812263
82MUSK0.61231324
83PKN10.60558157
84INSRR0.58815744
85CDK80.56636040
86RIPK10.54281190
87MAP3K60.52901064
88NEK60.52659490
89MOS0.51028440
90PDK10.51012567
91MAP3K70.50995172
92GRK70.50813745
93FER0.49869161
94WNK10.48808828
95MARK20.47706355
96ROCK20.47289717
97RPS6KA30.46767361
98CAMK40.45996175
99MAP3K10.45045315
100MAPK100.43749151
101PRKG10.43712567
102TYRO30.43128304
103DMPK0.43076511
104PDPK10.42497957
105CDC42BPA0.42340191
106PRKCH0.42013775
107WNK30.41783869
108PRKCZ0.41490571
109RET0.41336577
110DAPK30.41212511
111CSNK1E0.41128255
112CSNK1D0.41127269
113CAMK2G0.40846980
114MAPK70.40629825
115MAPK120.40256906
116MAP3K20.39813477
117CSNK1G10.39413680
118UHMK10.39268582
119FYN0.38789045
120MKNK20.37141739
121EPHB20.36438243
122CSNK1G30.31829137
123PRKACA0.30261339
124GSK3B0.29617612
125ROCK10.27489829

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.49894408
2Synaptic vesicle cycle_Homo sapiens_hsa047213.86731504
3GABAergic synapse_Homo sapiens_hsa047273.19852567
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.19051318
5Morphine addiction_Homo sapiens_hsa050322.98697719
6Circadian entrainment_Homo sapiens_hsa047132.83885537
7Olfactory transduction_Homo sapiens_hsa047402.55139921
8Glutamatergic synapse_Homo sapiens_hsa047242.51972065
9Salivary secretion_Homo sapiens_hsa049702.25701437
10Insulin secretion_Homo sapiens_hsa049112.18348608
11Amphetamine addiction_Homo sapiens_hsa050312.11764081
12Long-term potentiation_Homo sapiens_hsa047202.08854187
13Renin secretion_Homo sapiens_hsa049242.04423765
14Dopaminergic synapse_Homo sapiens_hsa047281.97110385
15Serotonergic synapse_Homo sapiens_hsa047261.91958726
16Collecting duct acid secretion_Homo sapiens_hsa049661.89581643
17Oxytocin signaling pathway_Homo sapiens_hsa049211.88528064
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.87847165
19Cholinergic synapse_Homo sapiens_hsa047251.87178018
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71285900
21Phototransduction_Homo sapiens_hsa047441.67764146
22Taste transduction_Homo sapiens_hsa047421.65146481
23Calcium signaling pathway_Homo sapiens_hsa040201.60058268
24Long-term depression_Homo sapiens_hsa047301.57891983
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57467031
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.52990144
27Vitamin B6 metabolism_Homo sapiens_hsa007501.49358855
28Circadian rhythm_Homo sapiens_hsa047101.48309689
29Gastric acid secretion_Homo sapiens_hsa049711.47957363
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.33727880
31Cocaine addiction_Homo sapiens_hsa050301.30972690
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.28723861
33GnRH signaling pathway_Homo sapiens_hsa049121.25972773
34Gap junction_Homo sapiens_hsa045401.24776126
35cAMP signaling pathway_Homo sapiens_hsa040241.24333637
36Cardiac muscle contraction_Homo sapiens_hsa042601.23794168
37Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.22437037
38cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20368221
39Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.17640793
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15365844
41Type II diabetes mellitus_Homo sapiens_hsa049301.07622725
42Dilated cardiomyopathy_Homo sapiens_hsa054141.06812631
43Vascular smooth muscle contraction_Homo sapiens_hsa042701.06643911
44Vibrio cholerae infection_Homo sapiens_hsa051101.06157567
45Phosphatidylinositol signaling system_Homo sapiens_hsa040701.06141791
46Maturity onset diabetes of the young_Homo sapiens_hsa049500.99466119
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94170844
48Axon guidance_Homo sapiens_hsa043600.92374060
49Hedgehog signaling pathway_Homo sapiens_hsa043400.86740549
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84130162
51ErbB signaling pathway_Homo sapiens_hsa040120.81152979
52MAPK signaling pathway_Homo sapiens_hsa040100.80507509
53Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.78175527
54Estrogen signaling pathway_Homo sapiens_hsa049150.78097056
55Hippo signaling pathway_Homo sapiens_hsa043900.76066965
56Glioma_Homo sapiens_hsa052140.75449364
57Pancreatic secretion_Homo sapiens_hsa049720.74296277
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.73008493
59Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.72543219
60Bile secretion_Homo sapiens_hsa049760.69288063
61Basal cell carcinoma_Homo sapiens_hsa052170.65906606
62Phospholipase D signaling pathway_Homo sapiens_hsa040720.65232190
63Choline metabolism in cancer_Homo sapiens_hsa052310.64770560
64Melanogenesis_Homo sapiens_hsa049160.64095320
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62867963
66Inositol phosphate metabolism_Homo sapiens_hsa005620.62559834
67Tight junction_Homo sapiens_hsa045300.60642340
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58044273
69Ras signaling pathway_Homo sapiens_hsa040140.56550757
70Notch signaling pathway_Homo sapiens_hsa043300.54511870
71Fructose and mannose metabolism_Homo sapiens_hsa000510.54314860
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54198462
73Rheumatoid arthritis_Homo sapiens_hsa053230.53465238
74Oocyte meiosis_Homo sapiens_hsa041140.53416292
75Thyroid hormone synthesis_Homo sapiens_hsa049180.52351379
76Mineral absorption_Homo sapiens_hsa049780.50450909
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50236696
78Protein digestion and absorption_Homo sapiens_hsa049740.48611717
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47656852
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47539817
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45150172
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44704259
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43618943
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43420211
85African trypanosomiasis_Homo sapiens_hsa051430.43365159
86Glucagon signaling pathway_Homo sapiens_hsa049220.43043515
87Butanoate metabolism_Homo sapiens_hsa006500.42642894
88mTOR signaling pathway_Homo sapiens_hsa041500.41969068
89Central carbon metabolism in cancer_Homo sapiens_hsa052300.41295780
90Dorso-ventral axis formation_Homo sapiens_hsa043200.40989345
91Renal cell carcinoma_Homo sapiens_hsa052110.39952370
92Rap1 signaling pathway_Homo sapiens_hsa040150.39920597
93Type I diabetes mellitus_Homo sapiens_hsa049400.38906436
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38225102
95Alcoholism_Homo sapiens_hsa050340.37333035
96VEGF signaling pathway_Homo sapiens_hsa043700.36502841
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35776445
98Ovarian steroidogenesis_Homo sapiens_hsa049130.33874292
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32693823
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32110793
101Sphingolipid signaling pathway_Homo sapiens_hsa040710.32028046
102Wnt signaling pathway_Homo sapiens_hsa043100.31195172
103Arginine and proline metabolism_Homo sapiens_hsa003300.28782801
104Melanoma_Homo sapiens_hsa052180.28634690
105Endocytosis_Homo sapiens_hsa041440.27183597
106Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25158707
107Endometrial cancer_Homo sapiens_hsa052130.24825437
108Adherens junction_Homo sapiens_hsa045200.24503894
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.24362378
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21430984
111AMPK signaling pathway_Homo sapiens_hsa041520.21388174
112Folate biosynthesis_Homo sapiens_hsa007900.21362570
113Chemokine signaling pathway_Homo sapiens_hsa040620.21346969
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.21269967
115HIF-1 signaling pathway_Homo sapiens_hsa040660.21050236
116Alzheimers disease_Homo sapiens_hsa050100.19146707
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.18297320
118Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17510210
119Phagosome_Homo sapiens_hsa041450.16975669

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