

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 5.55564875 |
| 2 | synaptic vesicle maturation (GO:0016188) | 5.51683811 |
| 3 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.31969024 |
| 4 | neuronal action potential propagation (GO:0019227) | 5.21841754 |
| 5 | cell migration in hindbrain (GO:0021535) | 4.89730720 |
| 6 | postsynaptic membrane organization (GO:0001941) | 4.85042609 |
| 7 | synaptic vesicle exocytosis (GO:0016079) | 4.73735513 |
| 8 | glutamate secretion (GO:0014047) | 4.69641185 |
| 9 | locomotory exploration behavior (GO:0035641) | 4.69269323 |
| 10 | neurofilament cytoskeleton organization (GO:0060052) | 4.66099447 |
| 11 | regulation of synaptic vesicle exocytosis (GO:2000300) | 4.59489380 |
| 12 | positive regulation of synapse maturation (GO:0090129) | 4.58197171 |
| 13 | protein localization to synapse (GO:0035418) | 4.41765231 |
| 14 | neuron cell-cell adhesion (GO:0007158) | 4.41457963 |
| 15 | layer formation in cerebral cortex (GO:0021819) | 4.38011707 |
| 16 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 4.35445627 |
| 17 | gamma-aminobutyric acid transport (GO:0015812) | 4.25823907 |
| 18 | vocalization behavior (GO:0071625) | 4.18823138 |
| 19 | negative regulation of dendrite morphogenesis (GO:0050774) | 4.11822061 |
| 20 | neurotransmitter secretion (GO:0007269) | 4.09299238 |
| 21 | proline transport (GO:0015824) | 4.08958999 |
| 22 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 4.08818076 |
| 23 | detection of temperature stimulus involved in sensory perception (GO:0050961) | 4.05997989 |
| 24 | detection of temperature stimulus involved in sensory perception of pain (GO:0050965) | 4.05997989 |
| 25 | regulation of synaptic vesicle transport (GO:1902803) | 4.03741169 |
| 26 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 3.98187792 |
| 27 | auditory behavior (GO:0031223) | 3.97315272 |
| 28 | detection of temperature stimulus (GO:0016048) | 3.97109630 |
| 29 | membrane depolarization during action potential (GO:0086010) | 3.89106586 |
| 30 | negative regulation of amyloid precursor protein catabolic process (GO:1902992) | 3.85706377 |
| 31 | cerebellar granule cell differentiation (GO:0021707) | 3.83681220 |
| 32 | neuronal action potential (GO:0019228) | 3.83387013 |
| 33 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.80088426 |
| 34 | L-amino acid import (GO:0043092) | 3.77342133 |
| 35 | negative regulation of microtubule polymerization (GO:0031115) | 3.75639731 |
| 36 | axon cargo transport (GO:0008088) | 3.75509387 |
| 37 | potassium ion import (GO:0010107) | 3.71842821 |
| 38 | cerebellar Purkinje cell differentiation (GO:0021702) | 3.70048890 |
| 39 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.69491982 |
| 40 | mating behavior (GO:0007617) | 3.64235448 |
| 41 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.64171807 |
| 42 | exploration behavior (GO:0035640) | 3.62962418 |
| 43 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 3.61713306 |
| 44 | axon ensheathment in central nervous system (GO:0032291) | 3.61209603 |
| 45 | central nervous system myelination (GO:0022010) | 3.61209603 |
| 46 | regulation of respiratory system process (GO:0044065) | 3.60244677 |
| 47 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.57715083 |
| 48 | sodium ion export (GO:0071436) | 3.57680903 |
| 49 | regulation of synapse maturation (GO:0090128) | 3.56960604 |
| 50 | cellular potassium ion homeostasis (GO:0030007) | 3.54893755 |
| 51 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 3.53675769 |
| 52 | cell communication by electrical coupling (GO:0010644) | 3.49996657 |
| 53 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.49812163 |
| 54 | negative regulation of dendrite development (GO:2000171) | 3.49656320 |
| 55 | neuromuscular process controlling posture (GO:0050884) | 3.48164931 |
| 56 | potassium ion homeostasis (GO:0055075) | 3.47557229 |
| 57 | synaptic vesicle endocytosis (GO:0048488) | 3.46766839 |
| 58 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.46251949 |
| 59 | amino acid import (GO:0043090) | 3.46084338 |
| 60 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.39199486 |
| 61 | activation of protein kinase A activity (GO:0034199) | 3.37676778 |
| 62 | innervation (GO:0060384) | 3.36855149 |
| 63 | cell communication involved in cardiac conduction (GO:0086065) | 3.36074689 |
| 64 | regulation of synapse structural plasticity (GO:0051823) | 3.35357604 |
| 65 | neuromuscular process controlling balance (GO:0050885) | 3.33177387 |
| 66 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.29411085 |
| 67 | neurotransmitter transport (GO:0006836) | 3.29194274 |
| 68 | positive regulation of dendritic spine development (GO:0060999) | 3.25165005 |
| 69 | presynaptic membrane assembly (GO:0097105) | 3.25037430 |
| 70 | presynaptic membrane organization (GO:0097090) | 3.23026226 |
| 71 | membrane repolarization (GO:0086009) | 3.18214799 |
| 72 | cerebellar Purkinje cell layer development (GO:0021680) | 3.17841801 |
| 73 | dendrite morphogenesis (GO:0048813) | 3.15879378 |
| 74 | synaptic transmission, glutamatergic (GO:0035249) | 3.12945430 |
| 75 | regulation of neurotransmitter secretion (GO:0046928) | 3.09266651 |
| 76 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.08818690 |
| 77 | regulation of neurotransmitter levels (GO:0001505) | 3.08714930 |
| 78 | peptidyl-arginine N-methylation (GO:0035246) | 3.08678341 |
| 79 | peptidyl-arginine methylation (GO:0018216) | 3.08678341 |
| 80 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 3.07362610 |
| 81 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.05387656 |
| 82 | cranial nerve morphogenesis (GO:0021602) | 3.05111097 |
| 83 | regulation of synaptic plasticity (GO:0048167) | 3.04744655 |
| 84 | calcium-mediated signaling using intracellular calcium source (GO:0035584) | 3.04372138 |
| 85 | myelin maintenance (GO:0043217) | 3.04031962 |
| 86 | regulation of respiratory gaseous exchange (GO:0043576) | 3.03326068 |
| 87 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.03325895 |
| 88 | mitochondrion transport along microtubule (GO:0047497) | 3.03325895 |
| 89 | prepulse inhibition (GO:0060134) | 3.02875053 |
| 90 | neuromuscular synaptic transmission (GO:0007274) | 3.02044302 |
| 91 | neuromuscular process (GO:0050905) | 3.01593397 |
| 92 | peripheral nervous system neuron development (GO:0048935) | 3.01366596 |
| 93 | neuron recognition (GO:0008038) | 2.99382181 |
| 94 | neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976) | 2.99236851 |
| 95 | neuron-neuron synaptic transmission (GO:0007270) | 2.98660767 |
| 96 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 2.98323822 |
| 97 | vesicle transport along microtubule (GO:0047496) | 2.97156956 |
| 98 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.97097594 |
| 99 | membrane depolarization (GO:0051899) | 2.96768168 |
| 100 | mechanosensory behavior (GO:0007638) | 2.95647775 |
| 101 | glutamate receptor signaling pathway (GO:0007215) | 2.95434894 |
| 102 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.94829842 |
| 103 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 2.94527474 |
| 104 | astrocyte differentiation (GO:0048708) | 2.94099647 |
| 105 | histone arginine methylation (GO:0034969) | 2.93309240 |
| 106 | organelle transport along microtubule (GO:0072384) | 2.92586612 |
| 107 | response to auditory stimulus (GO:0010996) | 2.92431405 |
| 108 | dendritic spine morphogenesis (GO:0060997) | 2.89926440 |
| 109 | neuronal ion channel clustering (GO:0045161) | 2.88886137 |
| 110 | adult walking behavior (GO:0007628) | 2.88813529 |
| 111 | synapse assembly (GO:0007416) | 2.87760452 |
| 112 | glycine transport (GO:0015816) | 2.87302480 |
| 113 | establishment of mitochondrion localization (GO:0051654) | 2.86574142 |
| 114 | membrane hyperpolarization (GO:0060081) | 2.86478632 |
| 115 | establishment of nucleus localization (GO:0040023) | 2.85535509 |
| 116 | neuron projection regeneration (GO:0031102) | 2.85142860 |
| 117 | alanine transport (GO:0032328) | 2.84452203 |
| 118 | transmission of nerve impulse (GO:0019226) | 2.83442912 |
| 119 | cellular sodium ion homeostasis (GO:0006883) | 2.82001816 |
| 120 | positive regulation of membrane potential (GO:0045838) | 2.81303286 |
| 121 | retinal ganglion cell axon guidance (GO:0031290) | 2.79999115 |
| 122 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.79425437 |
| 123 | dendritic spine organization (GO:0097061) | 2.79393325 |
| 124 | regulation of neurotransmitter transport (GO:0051588) | 2.79272004 |
| 125 | pyrimidine nucleobase catabolic process (GO:0006208) | 2.78492815 |
| 126 | aggressive behavior (GO:0002118) | 2.77286392 |
| 127 | regulation of mammary gland epithelial cell proliferation (GO:0033599) | 2.75969419 |
| 128 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 2.75964666 |
| 129 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 2.75329415 |
| 130 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.75319808 |
| 131 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.74320940 |
| 132 | synaptic transmission (GO:0007268) | 2.73224922 |
| 133 | negative regulation of catenin import into nucleus (GO:0035414) | 2.73071640 |
| 134 | regulation of dopamine secretion (GO:0014059) | 2.72211967 |
| 135 | regulation of vesicle fusion (GO:0031338) | 2.72178387 |
| 136 | regulation of neurotransmitter uptake (GO:0051580) | 2.71209228 |
| 137 | long-term memory (GO:0007616) | 2.71094726 |
| 138 | sodium ion transmembrane transport (GO:0035725) | 2.70921225 |
| 139 | regulation of postsynaptic membrane potential (GO:0060078) | 2.69132048 |
| 140 | astrocyte development (GO:0014002) | 2.68679404 |
| 141 | positive regulation of neurotransmitter transport (GO:0051590) | 2.66879051 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.36528652 |
| 2 | * SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 3.18218816 |
| 3 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 3.16454559 |
| 4 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 3.09443611 |
| 5 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 3.02179781 |
| 6 | * EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.97809239 |
| 7 | * RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.97809239 |
| 8 | GBX2_23144817_ChIP-Seq_PC3_Human | 2.74339048 |
| 9 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.66666182 |
| 10 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.65028109 |
| 11 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.63129896 |
| 12 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.62323398 |
| 13 | * SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.59238007 |
| 14 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.57638242 |
| 15 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.57232687 |
| 16 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.54830020 |
| 17 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.45638165 |
| 18 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 2.39565725 |
| 19 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.37943075 |
| 20 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 2.33766047 |
| 21 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.29850375 |
| 22 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.27335676 |
| 23 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 2.26351755 |
| 24 | LXR_22292898_ChIP-Seq_THP-1_Human | 2.26167302 |
| 25 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.25317513 |
| 26 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.08160869 |
| 27 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.99182387 |
| 28 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 1.98130793 |
| 29 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.90778989 |
| 30 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 1.78697119 |
| 31 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.77324875 |
| 32 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.74737072 |
| 33 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.72997525 |
| 34 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.67573127 |
| 35 | * MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.66551873 |
| 36 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.62316499 |
| 37 | * TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.60362379 |
| 38 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.56469901 |
| 39 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.53964515 |
| 40 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.51979978 |
| 41 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.51302353 |
| 42 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.51216824 |
| 43 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.51123213 |
| 44 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.47661327 |
| 45 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.45603748 |
| 46 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.45089794 |
| 47 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 1.42202591 |
| 48 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.42179460 |
| 49 | P68_20966046_ChIP-Seq_HELA_Human | 1.41589535 |
| 50 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.41583464 |
| 51 | KDM2B_26808549_Chip-Seq_K562_Human | 1.41100834 |
| 52 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.39984454 |
| 53 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.39191815 |
| 54 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.35838398 |
| 55 | ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.34607662 |
| 56 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.34409693 |
| 57 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.32710717 |
| 58 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.30825176 |
| 59 | SA1_27219007_Chip-Seq_ERYTHROID_Human | 1.30805919 |
| 60 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.27356641 |
| 61 | SMC4_20622854_ChIP-Seq_HELA_Human | 1.26266299 |
| 62 | KDM2B_26808549_Chip-Seq_DND41_Human | 1.26201897 |
| 63 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.25326807 |
| 64 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.24152631 |
| 65 | * SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.23823405 |
| 66 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.23548761 |
| 67 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.22819617 |
| 68 | KDM2B_26808549_Chip-Seq_SIL-ALL_Human | 1.22300094 |
| 69 | CREB1_26743006_Chip-Seq_LNCaP_Human | 1.20572444 |
| 70 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 1.20013832 |
| 71 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.19440555 |
| 72 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.18576178 |
| 73 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.18217879 |
| 74 | P300_19829295_ChIP-Seq_ESCs_Human | 1.16941619 |
| 75 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.16191998 |
| 76 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.15288218 |
| 77 | * WT1_25993318_ChIP-Seq_PODOCYTE_Human | 1.14748223 |
| 78 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.14329574 |
| 79 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 1.14302640 |
| 80 | AR_19668381_ChIP-Seq_PC3_Human | 1.13061374 |
| 81 | * OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.12588695 |
| 82 | CTCF_27219007_Chip-Seq_ERYTHROID_Human | 1.12552893 |
| 83 | * RING1B_27294783_Chip-Seq_NPCs_Mouse | 1.12180870 |
| 84 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 1.11177865 |
| 85 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.10595674 |
| 86 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08341979 |
| 87 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.07742379 |
| 88 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.07109943 |
| 89 | KDM2B_26808549_Chip-Seq_JURKAT_Human | 1.07105408 |
| 90 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.07007510 |
| 91 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.06978534 |
| 92 | SETDB1_19884255_ChIP-Seq_MESCs_Mouse | 1.06868968 |
| 93 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.06702625 |
| 94 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.05508855 |
| 95 | STAT3_23295773_ChIP-Seq_U87_Human | 1.04969643 |
| 96 | CREB1_26743006_Chip-Seq_LNCaP-abl_Human | 1.04951027 |
| 97 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.04770501 |
| 98 | AR_25329375_ChIP-Seq_VCAP_Human | 1.04747882 |
| 99 | * TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.03289212 |
| 100 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.99656335 |
| 101 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 0.99254075 |
| 102 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.99168260 |
| 103 | RNF2_27304074_Chip-Seq_NSC_Mouse | 0.98867716 |
| 104 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 0.98851551 |
| 105 | SOX3_22085726_ChIP-Seq_NPCs_Mouse | 0.98623987 |
| 106 | * CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.98200210 |
| 107 | YAP1_20516196_ChIP-Seq_MESCs_Mouse | 0.97575215 |
| 108 | EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse | 0.97198021 |
| 109 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.96986118 |
| 110 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.96474584 |
| 111 | OCT4_19829295_ChIP-Seq_ESCs_Human | 0.96294634 |
| 112 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.96076178 |
| 113 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 0.94905842 |
| 114 | * SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.94764678 |
| 115 | SA1_27219007_Chip-Seq_Bcells_Human | 0.94124680 |
| 116 | DMRT1_23473982_ChIP-Seq_TESTES_Mouse | 0.93774375 |
| 117 | XRN2_22483619_ChIP-Seq_HELA_Human | 0.92890542 |
| 118 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 0.92851841 |
| 119 | ELF1_20517297_ChIP-Seq_JURKAT_Human | 0.91786098 |
| 120 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.91740420 |
| 121 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.91686831 |
| 122 | POU5F1_16518401_ChIP-PET_MESCs_Mouse | 0.91029430 |
| 123 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.90823505 |
| 124 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.90644399 |
| 125 | TFAP2A_17053090_ChIP-ChIP_MCF-7_Human | 0.90540637 |
| 126 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.90411633 |
| 127 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 0.90394939 |
| 128 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 0.89880360 |
| 129 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.88778571 |
| 130 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 0.87874061 |
| 131 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.87346686 |
| 132 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 0.86792739 |
| 133 | KDM2B_26808549_Chip-Seq_SUP-B15_Human | 0.86544255 |
| 134 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.85274164 |
| 135 | CTCF_20526341_ChIP-Seq_ESCs_Human | 0.83911076 |
| 136 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 0.83894661 |
| 137 | TCF4_23295773_ChIP-Seq_U87_Human | 0.83211730 |
| 138 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 0.82906674 |
| 139 | * GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.81200367 |
| 140 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.80755686 |
| 141 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.79373235 |
| 142 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 0.79001606 |
| 143 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 0.78651055 |
| 144 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.78231816 |
| 145 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 0.78069078 |
| 146 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 0.77723931 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.31052425 |
| 2 | MP0002735_abnormal_chemical_nociception | 4.69840891 |
| 3 | MP0001968_abnormal_touch/_nociception | 4.61769134 |
| 4 | MP0004270_analgesia | 4.24055942 |
| 5 | MP0002736_abnormal_nociception_after | 3.80881013 |
| 6 | MP0003635_abnormal_synaptic_transmissio | 3.45366135 |
| 7 | MP0002734_abnormal_mechanical_nocicepti | 3.44312633 |
| 8 | MP0002733_abnormal_thermal_nociception | 3.41574117 |
| 9 | MP0003880_abnormal_central_pattern | 3.33422102 |
| 10 | MP0004858_abnormal_nervous_system | 3.23128932 |
| 11 | MP0006276_abnormal_autonomic_nervous | 3.06084146 |
| 12 | MP0001970_abnormal_pain_threshold | 2.94329965 |
| 13 | MP0002249_abnormal_larynx_morphology | 2.87144825 |
| 14 | MP0009046_muscle_twitch | 2.78062727 |
| 15 | MP0009745_abnormal_behavioral_response | 2.74655172 |
| 16 | MP0002064_seizures | 2.68307597 |
| 17 | MP0005423_abnormal_somatic_nervous | 2.68093836 |
| 18 | MP0002272_abnormal_nervous_system | 2.61028800 |
| 19 | MP0002063_abnormal_learning/memory/cond | 2.60862557 |
| 20 | MP0002184_abnormal_innervation | 2.36820157 |
| 21 | MP0002572_abnormal_emotion/affect_behav | 2.29207284 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.16898120 |
| 23 | MP0003329_amyloid_beta_deposits | 2.16603181 |
| 24 | MP0001486_abnormal_startle_reflex | 1.99239397 |
| 25 | MP0000955_abnormal_spinal_cord | 1.98875039 |
| 26 | MP0004811_abnormal_neuron_physiology | 1.92073029 |
| 27 | MP0000778_abnormal_nervous_system | 1.88626535 |
| 28 | MP0002822_catalepsy | 1.87021817 |
| 29 | MP0001440_abnormal_grooming_behavior | 1.83096258 |
| 30 | MP0001986_abnormal_taste_sensitivity | 1.83012759 |
| 31 | MP0001346_abnormal_lacrimal_gland | 1.71909059 |
| 32 | MP0001501_abnormal_sleep_pattern | 1.66080936 |
| 33 | MP0005623_abnormal_meninges_morphology | 1.65249464 |
| 34 | MP0002234_abnormal_pharynx_morphology | 1.63676736 |
| 35 | MP0008569_lethality_at_weaning | 1.52681363 |
| 36 | MP0002557_abnormal_social/conspecific_i | 1.50129193 |
| 37 | MP0002882_abnormal_neuron_morphology | 1.49288117 |
| 38 | MP0005386_behavior/neurological_phenoty | 1.44715761 |
| 39 | MP0004924_abnormal_behavior | 1.44715761 |
| 40 | MP0003879_abnormal_hair_cell | 1.44553143 |
| 41 | MP0002909_abnormal_adrenal_gland | 1.39264389 |
| 42 | MP0000049_abnormal_middle_ear | 1.34655072 |
| 43 | MP0002751_abnormal_autonomic_nervous | 1.33687929 |
| 44 | MP0002066_abnormal_motor_capabilities/c | 1.32707882 |
| 45 | MP0004142_abnormal_muscle_tone | 1.32308263 |
| 46 | MP0000681_abnormal_thyroid_gland | 1.30308242 |
| 47 | MP0003183_abnormal_peptide_metabolism | 1.30125541 |
| 48 | MP0001348_abnormal_lacrimal_gland | 1.26314713 |
| 49 | MP0008961_abnormal_basal_metabolism | 1.25766371 |
| 50 | MP0001984_abnormal_olfaction | 1.24933117 |
| 51 | MP0005083_abnormal_biliary_tract | 1.24311849 |
| 52 | MP0000566_synostosis | 1.24161137 |
| 53 | MP0009780_abnormal_chondrocyte_physiolo | 1.22702484 |
| 54 | MP0010030_abnormal_orbit_morphology | 1.20374471 |
| 55 | MP0000604_amyloidosis | 1.18828776 |
| 56 | MP0002229_neurodegeneration | 1.18727237 |
| 57 | MP0000751_myopathy | 1.18055350 |
| 58 | MP0004885_abnormal_endolymph | 1.16010997 |
| 59 | MP0003938_abnormal_ear_development | 1.15877041 |
| 60 | MP0003633_abnormal_nervous_system | 1.11959082 |
| 61 | MP0005167_abnormal_blood-brain_barrier | 1.10274290 |
| 62 | MP0002653_abnormal_ependyma_morphology | 1.08828627 |
| 63 | MP0000537_abnormal_urethra_morphology | 1.08218142 |
| 64 | MP0003122_maternal_imprinting | 1.07927469 |
| 65 | MP0000678_abnormal_parathyroid_gland | 1.07922844 |
| 66 | MP0008874_decreased_physiological_sensi | 1.07194272 |
| 67 | MP0009379_abnormal_foot_pigmentation | 1.06234599 |
| 68 | MP0003634_abnormal_glial_cell | 1.05498810 |
| 69 | MP0001529_abnormal_vocalization | 1.04943622 |
| 70 | MP0001905_abnormal_dopamine_level | 1.03607693 |
| 71 | MP0004145_abnormal_muscle_electrophysio | 1.00811383 |
| 72 | MP0000026_abnormal_inner_ear | 1.00174927 |
| 73 | MP0002752_abnormal_somatic_nervous | 0.98733362 |
| 74 | MP0003631_nervous_system_phenotype | 0.97160249 |
| 75 | MP0002152_abnormal_brain_morphology | 0.93491586 |
| 76 | MP0001502_abnormal_circadian_rhythm | 0.91900930 |
| 77 | MP0005645_abnormal_hypothalamus_physiol | 0.90203712 |
| 78 | MP0000631_abnormal_neuroendocrine_gland | 0.85526933 |
| 79 | MP0000920_abnormal_myelination | 0.85327375 |
| 80 | MP0000569_abnormal_digit_pigmentation | 0.85013143 |
| 81 | MP0005670_abnormal_white_adipose | 0.83375940 |
| 82 | MP0001270_distended_abdomen | 0.78645754 |
| 83 | MP0002069_abnormal_eating/drinking_beha | 0.77497243 |
| 84 | MP0002932_abnormal_joint_morphology | 0.76611003 |
| 85 | MP0004085_abnormal_heartbeat | 0.76001930 |
| 86 | MP0001299_abnormal_eye_distance/ | 0.74462184 |
| 87 | MP0002081_perinatal_lethality | 0.74420179 |
| 88 | MP0003942_abnormal_urinary_system | 0.74290187 |
| 89 | MP0003632_abnormal_nervous_system | 0.72542523 |
| 90 | MP0003136_yellow_coat_color | 0.72532326 |
| 91 | MP0005535_abnormal_body_temperature | 0.71659493 |
| 92 | MP0010769_abnormal_survival | 0.71076360 |
| 93 | MP0002837_dystrophic_cardiac_calcinosis | 0.69965006 |
| 94 | MP0000462_abnormal_digestive_system | 0.69959163 |
| 95 | MP0005646_abnormal_pituitary_gland | 0.69700057 |
| 96 | MP0004742_abnormal_vestibular_system | 0.68893877 |
| 97 | MP0001485_abnormal_pinna_reflex | 0.68874530 |
| 98 | MP0010770_preweaning_lethality | 0.68699898 |
| 99 | MP0002082_postnatal_lethality | 0.68699898 |
| 100 | MP0010768_mortality/aging | 0.68219165 |
| 101 | MP0005409_darkened_coat_color | 0.68101282 |
| 102 | MP0010386_abnormal_urinary_bladder | 0.67584035 |
| 103 | MP0002116_abnormal_craniofacial_bone | 0.67384845 |
| 104 | MP0003119_abnormal_digestive_system | 0.67313583 |
| 105 | MP0000733_abnormal_muscle_development | 0.66257934 |
| 106 | MP0008872_abnormal_physiological_respon | 0.65901787 |
| 107 | MP0005551_abnormal_eye_electrophysiolog | 0.65747458 |
| 108 | MP0001963_abnormal_hearing_physiology | 0.65576989 |
| 109 | MP0000013_abnormal_adipose_tissue | 0.65464579 |
| 110 | MP0003137_abnormal_impulse_conducting | 0.62663377 |
| 111 | MP0005187_abnormal_penis_morphology | 0.62220868 |
| 112 | MP0005499_abnormal_olfactory_system | 0.60948654 |
| 113 | MP0005394_taste/olfaction_phenotype | 0.60948654 |
| 114 | MP0001177_atelectasis | 0.59723993 |
| 115 | MP0000747_muscle_weakness | 0.59519590 |
| 116 | MP0001664_abnormal_digestion | 0.58703919 |
| 117 | MP0000534_abnormal_ureter_morphology | 0.57965549 |
| 118 | MP0002638_abnormal_pupillary_reflex | 0.57877403 |
| 119 | MP0001943_abnormal_respiration | 0.54558913 |
| 120 | MP0003868_abnormal_feces_composition | 0.54071217 |
| 121 | MP0003283_abnormal_digestive_organ | 0.53125305 |
| 122 | MP0004130_abnormal_muscle_cell | 0.52264155 |
| 123 | MP0003861_abnormal_nervous_system | 0.52257940 |
| 124 | MP0001188_hyperpigmentation | 0.51976323 |
| 125 | MP0003045_fibrosis | 0.50706520 |
| 126 | MP0004233_abnormal_muscle_weight | 0.49986192 |
| 127 | MP0003787_abnormal_imprinting | 0.49264621 |
| 128 | MP0003956_abnormal_body_size | 0.48522974 |
| 129 | MP0002163_abnormal_gland_morphology | 0.48089386 |
| 130 | MP0002876_abnormal_thyroid_physiology | 0.46649228 |
| 131 | MP0003690_abnormal_glial_cell | 0.46327273 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Myokymia (HP:0002411) | 8.60002764 |
| 2 | Double outlet right ventricle (HP:0001719) | 5.06998218 |
| 3 | Congenital malformation of the right heart (HP:0011723) | 5.06998218 |
| 4 | Ulnar claw (HP:0001178) | 4.82719652 |
| 5 | Focal motor seizures (HP:0011153) | 4.80372856 |
| 6 | Action tremor (HP:0002345) | 4.77229285 |
| 7 | Focal seizures (HP:0007359) | 4.61492001 |
| 8 | Febrile seizures (HP:0002373) | 4.45480392 |
| 9 | Progressive cerebellar ataxia (HP:0002073) | 4.38901863 |
| 10 | Pheochromocytoma (HP:0002666) | 4.27826704 |
| 11 | Insidious onset (HP:0003587) | 4.25577287 |
| 12 | Termporal pattern (HP:0011008) | 4.25577287 |
| 13 | Supranuclear gaze palsy (HP:0000605) | 4.01887829 |
| 14 | Visual hallucinations (HP:0002367) | 4.00240070 |
| 15 | Truncus arteriosus (HP:0001660) | 3.84813595 |
| 16 | Neuroendocrine neoplasm (HP:0100634) | 3.84585441 |
| 17 | Atonic seizures (HP:0010819) | 3.80833017 |
| 18 | Ankle clonus (HP:0011448) | 3.72479481 |
| 19 | Obstructive sleep apnea (HP:0002870) | 3.47185151 |
| 20 | Myotonia (HP:0002486) | 3.31598711 |
| 21 | Limb dystonia (HP:0002451) | 3.26344303 |
| 22 | Abnormal ventriculo-arterial connection (HP:0011563) | 3.20199953 |
| 23 | Transposition of the great arteries (HP:0001669) | 3.20199953 |
| 24 | Abnormal connection of the cardiac segments (HP:0011545) | 3.20199953 |
| 25 | Epileptic encephalopathy (HP:0200134) | 3.15122675 |
| 26 | Turricephaly (HP:0000262) | 3.13544489 |
| 27 | Absence seizures (HP:0002121) | 3.12803623 |
| 28 | Urinary bladder sphincter dysfunction (HP:0002839) | 3.12337515 |
| 29 | Annular pancreas (HP:0001734) | 3.11584339 |
| 30 | Impaired pain sensation (HP:0007328) | 3.06781181 |
| 31 | Abnormality of pain sensation (HP:0010832) | 3.06781181 |
| 32 | Truncal ataxia (HP:0002078) | 3.05539905 |
| 33 | Urinary urgency (HP:0000012) | 3.04532433 |
| 34 | Generalized tonic-clonic seizures (HP:0002069) | 2.98965386 |
| 35 | Morphological abnormality of the inner ear (HP:0011390) | 2.94755131 |
| 36 | Abnormality of the aortic arch (HP:0012303) | 2.89977015 |
| 37 | Postural tremor (HP:0002174) | 2.89414494 |
| 38 | Abnormality of the corticospinal tract (HP:0002492) | 2.87369778 |
| 39 | Preauricular pit (HP:0004467) | 2.86311500 |
| 40 | Periauricular skin pits (HP:0100277) | 2.86311500 |
| 41 | Abnormality of the lower motor neuron (HP:0002366) | 2.85368145 |
| 42 | Dialeptic seizures (HP:0011146) | 2.84196669 |
| 43 | Neoplasm of the peripheral nervous system (HP:0100007) | 2.80804943 |
| 44 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.79411096 |
| 45 | Torticollis (HP:0000473) | 2.77928767 |
| 46 | Peripheral hypomyelination (HP:0007182) | 2.77147633 |
| 47 | Hypercortisolism (HP:0001578) | 2.74631284 |
| 48 | Spastic gait (HP:0002064) | 2.72462974 |
| 49 | Hammertoe (HP:0001765) | 2.70224889 |
| 50 | Diplopia (HP:0000651) | 2.70131709 |
| 51 | Abnormality of binocular vision (HP:0011514) | 2.70131709 |
| 52 | Ventricular fibrillation (HP:0001663) | 2.66745696 |
| 53 | Mutism (HP:0002300) | 2.65169720 |
| 54 | Hypoplastic left heart (HP:0004383) | 2.61631329 |
| 55 | Gaze-evoked nystagmus (HP:0000640) | 2.59412174 |
| 56 | Hyperacusis (HP:0010780) | 2.58969116 |
| 57 | Depression (HP:0000716) | 2.58666592 |
| 58 | Akinesia (HP:0002304) | 2.57458862 |
| 59 | Abnormality of cochlea (HP:0000375) | 2.55361624 |
| 60 | Failure to thrive in infancy (HP:0001531) | 2.54856425 |
| 61 | Segmental peripheral demyelination/remyelination (HP:0003481) | 2.54447475 |
| 62 | Agitation (HP:0000713) | 2.53741495 |
| 63 | Papilledema (HP:0001085) | 2.53121254 |
| 64 | Progressive inability to walk (HP:0002505) | 2.51222190 |
| 65 | Dysmetria (HP:0001310) | 2.49186190 |
| 66 | Broad distal phalanx of finger (HP:0009836) | 2.49117634 |
| 67 | Amblyopia (HP:0000646) | 2.46182322 |
| 68 | Vertebral arch anomaly (HP:0008438) | 2.41681176 |
| 69 | Anxiety (HP:0000739) | 2.41098192 |
| 70 | Focal dystonia (HP:0004373) | 2.40752031 |
| 71 | Thoracolumbar scoliosis (HP:0002944) | 2.40203809 |
| 72 | Scanning speech (HP:0002168) | 2.40062083 |
| 73 | Craniofacial dystonia (HP:0012179) | 2.37600229 |
| 74 | Abnormality of the vocal cords (HP:0008777) | 2.35677588 |
| 75 | Steppage gait (HP:0003376) | 2.35074889 |
| 76 | Foot dorsiflexor weakness (HP:0009027) | 2.34350701 |
| 77 | Hypoplasia of the brainstem (HP:0002365) | 2.33361502 |
| 78 | Aplasia/Hypoplasia of the brainstem (HP:0007362) | 2.33361502 |
| 79 | Insomnia (HP:0100785) | 2.33134382 |
| 80 | Abnormality of chromosome segregation (HP:0002916) | 2.31555340 |
| 81 | Cerebral hemorrhage (HP:0001342) | 2.29261935 |
| 82 | Abnormal eating behavior (HP:0100738) | 2.27169083 |
| 83 | Hyperventilation (HP:0002883) | 2.26510055 |
| 84 | Hyperthyroidism (HP:0000836) | 2.25469917 |
| 85 | Hypoventilation (HP:0002791) | 2.22430320 |
| 86 | Anomalous pulmonary venous return (HP:0010772) | 2.22002926 |
| 87 | Lower limb muscle weakness (HP:0007340) | 2.20756541 |
| 88 | Sleep apnea (HP:0010535) | 2.19463860 |
| 89 | Postural instability (HP:0002172) | 2.19142199 |
| 90 | Megalencephaly (HP:0001355) | 2.18430937 |
| 91 | Onion bulb formation (HP:0003383) | 2.18334948 |
| 92 | Decreased number of peripheral myelinated nerve fibers (HP:0003380) | 2.17921901 |
| 93 | Aplasia involving bones of the extremities (HP:0009825) | 2.15029212 |
| 94 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.15029212 |
| 95 | Aplasia of the phalanges of the hand (HP:0009802) | 2.15029212 |
| 96 | Abnormal social behavior (HP:0012433) | 2.14714877 |
| 97 | Impaired social interactions (HP:0000735) | 2.14714877 |
| 98 | Cerebral hypomyelination (HP:0006808) | 2.14101018 |
| 99 | Poor eye contact (HP:0000817) | 2.13840773 |
| 100 | Distal sensory impairment (HP:0002936) | 2.13435389 |
| 101 | Skin pits (HP:0100276) | 2.12676247 |
| 102 | Decreased number of large peripheral myelinated nerve fibers (HP:0003387) | 2.11203142 |
| 103 | Dysdiadochokinesis (HP:0002075) | 2.11156490 |
| 104 | Hypoplastic heart (HP:0001961) | 2.10637481 |
| 105 | Bowel incontinence (HP:0002607) | 2.09347958 |
| 106 | Abnormality of the foot musculature (HP:0001436) | 2.08727762 |
| 107 | Impaired smooth pursuit (HP:0007772) | 2.06238212 |
| 108 | Athetosis (HP:0002305) | 2.05323436 |
| 109 | Neurofibrillary tangles (HP:0002185) | 2.04422971 |
| 110 | Alacrima (HP:0000522) | 2.03525042 |
| 111 | Abnormal large intestine physiology (HP:0012700) | 2.01504799 |
| 112 | Morphological abnormality of the pyramidal tract (HP:0002062) | 1.99505943 |
| 113 | Clonus (HP:0002169) | 1.98755481 |
| 114 | Hemiparesis (HP:0001269) | 1.98446140 |
| 115 | Anosmia (HP:0000458) | 1.97956463 |
| 116 | Split foot (HP:0001839) | 1.97244671 |
| 117 | Overriding aorta (HP:0002623) | 1.97114744 |
| 118 | Gait ataxia (HP:0002066) | 1.95674291 |
| 119 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 1.94613450 |
| 120 | Decreased motor nerve conduction velocity (HP:0003431) | 1.93904215 |
| 121 | Partial duplication of thumb phalanx (HP:0009944) | 1.92828750 |
| 122 | Cerebral inclusion bodies (HP:0100314) | 1.92749264 |
| 123 | Stereotypic behavior (HP:0000733) | 1.92223410 |
| 124 | Mask-like facies (HP:0000298) | 1.90126787 |
| 125 | Paraplegia (HP:0010550) | 1.89134819 |
| 126 | Elfin facies (HP:0004428) | 1.88866226 |
| 127 | Abnormality of the pulmonary veins (HP:0011718) | 1.88499594 |
| 128 | Status epilepticus (HP:0002133) | 1.88496656 |
| 129 | Spastic tetraparesis (HP:0001285) | 1.86852929 |
| 130 | Pointed chin (HP:0000307) | 1.86639297 |
| 131 | Aqueductal stenosis (HP:0002410) | 1.84881244 |
| 132 | Hemiplegia (HP:0002301) | 1.83921950 |
| 133 | Distal arthrogryposis (HP:0005684) | 1.82835153 |
| 134 | Spastic tetraplegia (HP:0002510) | 1.82718383 |
| 135 | Abnormality of the 4th metacarpal (HP:0010012) | 1.82429483 |
| 136 | Dysautonomia (HP:0002459) | 1.80368952 |
| 137 | J-shaped sella turcica (HP:0002680) | 1.80019984 |
| 138 | Bell-shaped thorax (HP:0001591) | 1.79774408 |
| 139 | Neuronal loss in central nervous system (HP:0002529) | 1.79496129 |
| 140 | Lower limb asymmetry (HP:0100559) | 1.79012257 |
| 141 | Sensory axonal neuropathy (HP:0003390) | 1.78978543 |
| 142 | Retinal dysplasia (HP:0007973) | 1.78443729 |
| 143 | Unsteady gait (HP:0002317) | 1.78412931 |
| 144 | Epileptiform EEG discharges (HP:0011182) | 1.77902259 |
| 145 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.77839522 |
| 146 | Bradykinesia (HP:0002067) | 1.77704893 |
| 147 | Impaired vibratory sensation (HP:0002495) | 1.77662935 |
| 148 | Spastic paraplegia (HP:0001258) | 1.77314273 |
| 149 | Tetraplegia (HP:0002445) | 1.77171918 |
| 150 | Psychosis (HP:0000709) | 1.76756088 |
| 151 | Intention tremor (HP:0002080) | 1.76426062 |
| 152 | Inability to walk (HP:0002540) | 1.75931537 |
| 153 | Drooling (HP:0002307) | 1.75695892 |
| 154 | Rigidity (HP:0002063) | 1.74797436 |
| 155 | Dysmetric saccades (HP:0000641) | 1.74104442 |
| 156 | Pulmonary artery stenosis (HP:0004415) | 1.71118265 |
| 157 | Unilateral renal agenesis (HP:0000122) | 1.67691516 |
| 158 | Partial duplication of the phalanx of hand (HP:0009999) | 1.66633296 |
| 159 | Renal duplication (HP:0000075) | 1.66332502 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MAP3K9 | 4.32098951 |
| 2 | NTRK3 | 4.18767678 |
| 3 | TRIB3 | 4.15482697 |
| 4 | GRK5 | 3.45015106 |
| 5 | KSR2 | 3.17003789 |
| 6 | SMG1 | 3.11326994 |
| 7 | MINK1 | 3.09718743 |
| 8 | NTRK1 | 2.97171592 |
| 9 | MARK1 | 2.95180903 |
| 10 | MAP3K4 | 2.43836024 |
| 11 | ARAF | 2.41649604 |
| 12 | MAP3K2 | 2.31651758 |
| 13 | LATS2 | 2.27766037 |
| 14 | LMTK2 | 2.19091894 |
| 15 | DAPK2 | 2.06279813 |
| 16 | PAK6 | 2.01222873 |
| 17 | RET | 2.00297187 |
| 18 | MAP3K12 | 1.97209955 |
| 19 | NTRK2 | 1.87442473 |
| 20 | MAP2K4 | 1.85868280 |
| 21 | LIMK1 | 1.81423798 |
| 22 | PKN1 | 1.76706206 |
| 23 | MAP2K7 | 1.74498640 |
| 24 | MAPK13 | 1.69908711 |
| 25 | DDR2 | 1.64009664 |
| 26 | EEF2K | 1.54502125 |
| 27 | TAF1 | 1.53909139 |
| 28 | PHKG2 | 1.47866678 |
| 29 | PHKG1 | 1.47866678 |
| 30 | EPHA4 | 1.47041910 |
| 31 | TAOK1 | 1.45477948 |
| 32 | INSRR | 1.42820534 |
| 33 | CDK5 | 1.34707266 |
| 34 | IRAK3 | 1.30856690 |
| 35 | RIPK4 | 1.30186633 |
| 36 | VRK2 | 1.30147511 |
| 37 | CAMKK1 | 1.29782256 |
| 38 | UHMK1 | 1.28737398 |
| 39 | CAMK1G | 1.28069439 |
| 40 | SIK2 | 1.26334888 |
| 41 | PRPF4B | 1.23251211 |
| 42 | CAMK1D | 1.23159573 |
| 43 | DYRK2 | 1.21520120 |
| 44 | IRAK2 | 1.20783120 |
| 45 | CSNK1A1L | 1.15465738 |
| 46 | PRKD3 | 1.14615712 |
| 47 | FES | 1.07270480 |
| 48 | CDK14 | 1.06387864 |
| 49 | KSR1 | 1.03666199 |
| 50 | FGFR2 | 1.00199077 |
| 51 | SGK223 | 0.95986394 |
| 52 | SGK494 | 0.95986394 |
| 53 | MAP3K1 | 0.95262036 |
| 54 | STK38 | 0.94279461 |
| 55 | PRKCG | 0.92725836 |
| 56 | CASK | 0.92725696 |
| 57 | MAP2K1 | 0.92015883 |
| 58 | CDK8 | 0.89600150 |
| 59 | PLK2 | 0.88437401 |
| 60 | CDK15 | 0.88296637 |
| 61 | CDK18 | 0.88275657 |
| 62 | ICK | 0.88062003 |
| 63 | RPS6KA2 | 0.86996933 |
| 64 | DAPK3 | 0.86577503 |
| 65 | CSNK1G1 | 0.84928746 |
| 66 | WNK1 | 0.84269972 |
| 67 | CAMK4 | 0.80033198 |
| 68 | PAK3 | 0.80019720 |
| 69 | DAPK1 | 0.78422660 |
| 70 | CDK11A | 0.77666322 |
| 71 | DYRK1A | 0.76771389 |
| 72 | AURKA | 0.76511970 |
| 73 | MATK | 0.75223010 |
| 74 | MAPK12 | 0.72134108 |
| 75 | SCYL2 | 0.71734638 |
| 76 | PINK1 | 0.69404493 |
| 77 | CSNK1G2 | 0.68416444 |
| 78 | FER | 0.67824569 |
| 79 | RAF1 | 0.67105560 |
| 80 | BMPR1B | 0.66040403 |
| 81 | SGK2 | 0.65372128 |
| 82 | PRKCZ | 0.64249781 |
| 83 | CHEK2 | 0.63969673 |
| 84 | PTK2B | 0.62493349 |
| 85 | TYRO3 | 0.62237607 |
| 86 | TNIK | 0.60691932 |
| 87 | NEK1 | 0.60591005 |
| 88 | MAPK10 | 0.60068963 |
| 89 | MAPKAPK3 | 0.60043375 |
| 90 | CAMK2A | 0.59649478 |
| 91 | PRKCH | 0.58872243 |
| 92 | MAPKAPK5 | 0.58800955 |
| 93 | EPHB2 | 0.58231532 |
| 94 | BRAF | 0.55305197 |
| 95 | SGK3 | 0.55284504 |
| 96 | PNCK | 0.54788912 |
| 97 | STK11 | 0.54653039 |
| 98 | PDPK1 | 0.54247714 |
| 99 | CDK19 | 0.52577256 |
| 100 | MAPK11 | 0.52502874 |
| 101 | CDC42BPA | 0.52502704 |
| 102 | PDK1 | 0.51449378 |
| 103 | CDK12 | 0.50877721 |
| 104 | STK39 | 0.50567390 |
| 105 | ROCK1 | 0.50043722 |
| 106 | MARK2 | 0.50006643 |
| 107 | RPS6KA5 | 0.49312178 |
| 108 | ALK | 0.49272941 |
| 109 | RIPK1 | 0.47761649 |
| 110 | DYRK1B | 0.47063044 |
| 111 | CAMKK2 | 0.45135737 |
| 112 | ADRBK1 | 0.43905298 |
| 113 | ROCK2 | 0.43339232 |
| 114 | SGK1 | 0.42830024 |
| 115 | TNK2 | 0.42219759 |
| 116 | MAP3K11 | 0.41829128 |
| 117 | FYN | 0.41542166 |
| 118 | CAMK1 | 0.41247845 |
| 119 | KDR | 0.41153313 |
| 120 | BUB1 | 0.39944254 |
| 121 | ILK | 0.39886533 |
| 122 | NEK6 | 0.39562057 |
| 123 | PRKAA1 | 0.39401706 |
| 124 | WNK4 | 0.39048138 |
| 125 | MAPK4 | 0.38955946 |
| 126 | AKT2 | 0.38810461 |
| 127 | STK16 | 0.38578670 |
| 128 | CSNK1G3 | 0.38025363 |
| 129 | CAMK2G | 0.37666817 |
| 130 | MTOR | 0.36953407 |
| 131 | CAMK2D | 0.36113322 |
| 132 | MAP3K13 | 0.35729223 |
| 133 | MAP3K10 | 0.35345026 |
| 134 | BRSK1 | 0.34391250 |
| 135 | PRKCE | 0.34062563 |
| 136 | ABL2 | 0.33431232 |
| 137 | RPS6KA3 | 0.32272417 |
| 138 | PRKACA | 0.31784774 |
| 139 | PRKACG | 0.30670602 |
| 140 | CAMK2B | 0.30189697 |
| 141 | CSNK1E | 0.28792861 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.64816132 |
| 2 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 2.77673009 |
| 3 | Nicotine addiction_Homo sapiens_hsa05033 | 2.68853764 |
| 4 | Olfactory transduction_Homo sapiens_hsa04740 | 2.41540406 |
| 5 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 2.38570711 |
| 6 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 2.35750630 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.31872671 |
| 8 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 2.16791917 |
| 9 | Sulfur relay system_Homo sapiens_hsa04122 | 2.16219193 |
| 10 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.11593418 |
| 11 | Circadian entrainment_Homo sapiens_hsa04713 | 2.10126225 |
| 12 | Long-term potentiation_Homo sapiens_hsa04720 | 2.05671221 |
| 13 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.04573401 |
| 14 | Taste transduction_Homo sapiens_hsa04742 | 1.94377157 |
| 15 | Morphine addiction_Homo sapiens_hsa05032 | 1.93647262 |
| 16 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 1.93401304 |
| 17 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.91925950 |
| 18 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.88466276 |
| 19 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.79474392 |
| 20 | Insulin secretion_Homo sapiens_hsa04911 | 1.77440860 |
| 21 | Salivary secretion_Homo sapiens_hsa04970 | 1.76203675 |
| 22 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.63140652 |
| 23 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.62203109 |
| 24 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.45637528 |
| 25 | Notch signaling pathway_Homo sapiens_hsa04330 | 1.45502190 |
| 26 | Long-term depression_Homo sapiens_hsa04730 | 1.43243977 |
| 27 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.40653517 |
| 28 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.39642002 |
| 29 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.39582056 |
| 30 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.38736319 |
| 31 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.37725678 |
| 32 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 1.35402989 |
| 33 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 1.35317852 |
| 34 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.29291424 |
| 35 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 1.29134770 |
| 36 | Gap junction_Homo sapiens_hsa04540 | 1.27279999 |
| 37 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.27061396 |
| 38 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.26924736 |
| 39 | Cocaine addiction_Homo sapiens_hsa05030 | 1.24845936 |
| 40 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.18905199 |
| 41 | Glioma_Homo sapiens_hsa05214 | 1.18210388 |
| 42 | Renin secretion_Homo sapiens_hsa04924 | 1.17473197 |
| 43 | Basal cell carcinoma_Homo sapiens_hsa05217 | 1.13991800 |
| 44 | Axon guidance_Homo sapiens_hsa04360 | 1.11109699 |
| 45 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.08918279 |
| 46 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 1.08773583 |
| 47 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.07699873 |
| 48 | Bile secretion_Homo sapiens_hsa04976 | 1.06124805 |
| 49 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 1.05353662 |
| 50 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 1.04131500 |
| 51 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.03060982 |
| 52 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 0.99149538 |
| 53 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.97209742 |
| 54 | Melanogenesis_Homo sapiens_hsa04916 | 0.93496808 |
| 55 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.91529490 |
| 56 | Parkinsons disease_Homo sapiens_hsa05012 | 0.89795723 |
| 57 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.89054600 |
| 58 | cAMP signaling pathway_Homo sapiens_hsa04024 | 0.87956230 |
| 59 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.87634964 |
| 60 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.85914516 |
| 61 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.85269622 |
| 62 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.81959453 |
| 63 | Endometrial cancer_Homo sapiens_hsa05213 | 0.81705953 |
| 64 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.80797882 |
| 65 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.80480466 |
| 66 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.79584609 |
| 67 | Thyroid cancer_Homo sapiens_hsa05216 | 0.79283087 |
| 68 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.79242730 |
| 69 | Alzheimers disease_Homo sapiens_hsa05010 | 0.79117673 |
| 70 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.78049060 |
| 71 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.77721595 |
| 72 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.76950429 |
| 73 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.74718907 |
| 74 | Alcoholism_Homo sapiens_hsa05034 | 0.74627598 |
| 75 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.74538616 |
| 76 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.74121851 |
| 77 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.72531915 |
| 78 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.68974274 |
| 79 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.68735540 |
| 80 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.68326368 |
| 81 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.67336572 |
| 82 | Prion diseases_Homo sapiens_hsa05020 | 0.66023324 |
| 83 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.65933655 |
| 84 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.65329892 |
| 85 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.64403812 |
| 86 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.64143301 |
| 87 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.63983268 |
| 88 | DNA replication_Homo sapiens_hsa03030 | 0.61970341 |
| 89 | Colorectal cancer_Homo sapiens_hsa05210 | 0.61846493 |
| 90 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.61653669 |
| 91 | Phototransduction_Homo sapiens_hsa04744 | 0.61166566 |
| 92 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.59828798 |
| 93 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.59777381 |
| 94 | Endocytosis_Homo sapiens_hsa04144 | 0.59421458 |
| 95 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.58987413 |
| 96 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.58286320 |
| 97 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.57992574 |
| 98 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57821730 |
| 99 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 0.57067456 |
| 100 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.57024199 |
| 101 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.56335966 |
| 102 | Ribosome_Homo sapiens_hsa03010 | 0.53734705 |
| 103 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.52646933 |
| 104 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.52547885 |
| 105 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.51098340 |
| 106 | Bladder cancer_Homo sapiens_hsa05219 | 0.50575106 |
| 107 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.50237414 |
| 108 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.49233500 |
| 109 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.48968549 |
| 110 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.47665838 |
| 111 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.47298407 |
| 112 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.46784336 |
| 113 | Prolactin signaling pathway_Homo sapiens_hsa04917 | 0.44690975 |
| 114 | Melanoma_Homo sapiens_hsa05218 | 0.42794521 |
| 115 | Huntingtons disease_Homo sapiens_hsa05016 | 0.41680935 |
| 116 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.41218181 |
| 117 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.38210944 |
| 118 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.37988268 |
| 119 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 0.37621418 |
| 120 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.33515580 |
| 121 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.33252251 |
| 122 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.32740741 |
| 123 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.32186232 |
| 124 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.32129913 |

