TMEM133

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There is evidence that this intronless gene is transcribed but the protein is predicted. The gene function is unknown. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.34564202
2regulation of cardioblast differentiation (GO:0051890)4.18060809
3cardiac right ventricle morphogenesis (GO:0003215)3.98264769
4ventricular cardiac muscle cell development (GO:0055015)3.80550607
5positive regulation of catenin import into nucleus (GO:0035413)3.77015912
6anterior/posterior axis specification, embryo (GO:0008595)3.57315923
7negative regulation of hormone biosynthetic process (GO:0032353)3.54785847
8positive regulation of cardiac muscle cell proliferation (GO:0060045)3.40943543
9negative regulation of striated muscle cell apoptotic process (GO:0010664)3.31781171
10endocardial cushion morphogenesis (GO:0003203)3.20261348
11negative regulation of hormone metabolic process (GO:0032351)3.18830872
12paraxial mesoderm development (GO:0048339)3.16246187
13positive regulation of cardiac muscle tissue growth (GO:0055023)3.15956041
14sequestering of extracellular ligand from receptor (GO:0035581)3.12782934
15pre-miRNA processing (GO:0031054)3.09875880
16positive regulation of cardiac muscle tissue development (GO:0055025)3.04004186
17anterior/posterior axis specification (GO:0009948)3.00246508
18positive regulation of heart growth (GO:0060421)2.99872113
19cardiac myofibril assembly (GO:0055003)2.98565707
20cell migration involved in gastrulation (GO:0042074)2.96829568
21regulation of transforming growth factor beta2 production (GO:0032909)2.96726614
22embryonic foregut morphogenesis (GO:0048617)2.95207680
23regulation of relaxation of muscle (GO:1901077)2.88346654
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.86851093
25regulation of cardiac muscle cell proliferation (GO:0060043)2.86708602
26atrial septum morphogenesis (GO:0060413)2.83757810
27regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.80651138
28positive regulation of SMAD protein import into nucleus (GO:0060391)2.79386686
29mesenchyme morphogenesis (GO:0072132)2.72546938
30establishment of apical/basal cell polarity (GO:0035089)2.72324070
31regulation of mesoderm development (GO:2000380)2.69234799
32nodal signaling pathway (GO:0038092)2.67789340
33notochord development (GO:0030903)2.67771267
34cardiac epithelial to mesenchymal transition (GO:0060317)2.65375312
35atrioventricular valve morphogenesis (GO:0003181)2.65061736
36cardiac muscle hypertrophy (GO:0003300)2.64144644
37mesenchymal cell development (GO:0014031)2.61519013
38establishment of monopolar cell polarity (GO:0061162)2.60800127
39establishment or maintenance of monopolar cell polarity (GO:0061339)2.60800127
40striated muscle hypertrophy (GO:0014897)2.60662720
41uterus development (GO:0060065)2.59277020
42regulation of acyl-CoA biosynthetic process (GO:0050812)2.58813573
43regulation of cardiac muscle cell apoptotic process (GO:0010665)2.57656629
44gastrulation with mouth forming second (GO:0001702)2.56575189
45neural crest cell development (GO:0014032)2.56350723
46regulation of cofactor metabolic process (GO:0051193)2.55400616
47regulation of coenzyme metabolic process (GO:0051196)2.55400616
48dorsal/ventral axis specification (GO:0009950)2.54786034
49regulation of cardiac muscle tissue development (GO:0055024)2.54439748
50regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.53929096
51gap junction assembly (GO:0016264)2.52211808
52relaxation of cardiac muscle (GO:0055119)2.50757188
53signal transduction involved in regulation of gene expression (GO:0023019)2.48712076
54SMAD protein signal transduction (GO:0060395)2.48371839
55response to BMP (GO:0071772)2.44759243
56cellular response to BMP stimulus (GO:0071773)2.44759243
57heart valve formation (GO:0003188)2.44113245
58female gonad development (GO:0008585)2.41152088
59heart valve morphogenesis (GO:0003179)2.40357566
60chromatin remodeling at centromere (GO:0031055)2.39663775
61cardiac muscle cell development (GO:0055013)2.39154348
62regulation of sulfur metabolic process (GO:0042762)2.39130003
63outflow tract septum morphogenesis (GO:0003148)2.39075100
64myofibril assembly (GO:0030239)2.38093446
65cell surface receptor signaling pathway involved in heart development (GO:0061311)2.36786238
66CENP-A containing nucleosome assembly (GO:0034080)2.36229485
67regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.35711178
68retina vasculature morphogenesis in camera-type eye (GO:0061299)2.34368694
69embryonic axis specification (GO:0000578)2.34134566
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.33590475
71cardiac cell development (GO:0055006)2.32890896
72regulation of cardiac muscle tissue growth (GO:0055021)2.32137006
73negative regulation of chondrocyte differentiation (GO:0032331)2.30385234
74regulation of SMAD protein import into nucleus (GO:0060390)2.28791063
75regulation of catenin import into nucleus (GO:0035412)2.27557831
76bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27119344
77regulation of activin receptor signaling pathway (GO:0032925)2.26979543
78cardiac muscle hypertrophy in response to stress (GO:0014898)2.26417489
79muscle hypertrophy in response to stress (GO:0003299)2.26417489
80cardiac muscle adaptation (GO:0014887)2.26417489
81hippo signaling (GO:0035329)2.26316881
82vascular smooth muscle contraction (GO:0014829)2.25776332
83positive regulation of cardiac muscle hypertrophy (GO:0010613)2.25591997
84positive regulation of muscle hypertrophy (GO:0014742)2.25591997
85embryonic heart tube development (GO:0035050)2.24708038
86proteasome assembly (GO:0043248)2.24035703
87regulation of glucocorticoid metabolic process (GO:0031943)2.23828083
88regulation of striated muscle cell apoptotic process (GO:0010662)2.22833352
89regulation of cell communication by electrical coupling (GO:0010649)2.22346817
90regulation of non-canonical Wnt signaling pathway (GO:2000050)2.20961076
91intraciliary transport (GO:0042073)2.19395371
92otic vesicle formation (GO:0030916)2.18072490
93lysine metabolic process (GO:0006553)2.16951047
94lysine catabolic process (GO:0006554)2.16951047
95regulation of heart growth (GO:0060420)2.16100441
96somite rostral/caudal axis specification (GO:0032525)2.15959750
97negative regulation of keratinocyte proliferation (GO:0010839)2.15948577
98outer ear morphogenesis (GO:0042473)2.15197241
99mesenchymal cell differentiation (GO:0048762)2.13588164
100regulation of steroid hormone biosynthetic process (GO:0090030)2.13312159

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24883721
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49626439
3AR_21909140_ChIP-Seq_LNCAP_Human2.41634160
4CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.35569781
5VDR_22108803_ChIP-Seq_LS180_Human2.25437369
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.16758480
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.14156809
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.12960553
9WT1_19549856_ChIP-ChIP_CCG9911_Human2.11567937
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.03789933
11FUS_26573619_Chip-Seq_HEK293_Human2.01533337
12EP300_21415370_ChIP-Seq_HL-1_Mouse1.95944542
13PIAS1_25552417_ChIP-Seq_VCAP_Human1.89100821
14P300_19829295_ChIP-Seq_ESCs_Human1.84131417
15CDX2_19796622_ChIP-Seq_MESCs_Mouse1.75498329
16EWS_26573619_Chip-Seq_HEK293_Human1.75015390
17AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.72705923
18KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.70013800
19SMAD3_21741376_ChIP-Seq_EPCs_Human1.69287794
20ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66619270
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64814405
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.63331719
23SMAD3_21741376_ChIP-Seq_HESCs_Human1.59215802
24OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.57447408
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.56678054
26ELK1_19687146_ChIP-ChIP_HELA_Human1.53179522
27KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.52895930
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.52895930
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.52895930
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51447991
31TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51265929
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47446608
33SALL4_18804426_ChIP-ChIP_XEN_Mouse1.43067978
34RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.42876874
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.41498393
36STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.41290609
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41288959
38TOP2B_26459242_ChIP-Seq_MCF-7_Human1.41091883
39TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.40129036
40ISL1_27105846_Chip-Seq_CPCs_Mouse1.38650386
41TAF15_26573619_Chip-Seq_HEK293_Human1.38093541
42MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32550088
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.31682627
44E2F7_22180533_ChIP-Seq_HELA_Human1.29708325
45NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29446798
46NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29446798
47GBX2_23144817_ChIP-Seq_PC3_Human1.27561189
48NANOG_16153702_ChIP-ChIP_HESCs_Human1.26515760
49SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.25877438
50* SMAD4_21799915_ChIP-Seq_A2780_Human1.25276421
51GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.25163346
52TCF3_18692474_ChIP-Seq_MESCs_Mouse1.24888202
53* EOMES_21245162_ChIP-Seq_HESCs_Human1.24735520
54* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.24166259
55TBX3_20139965_ChIP-Seq_ESCs_Mouse1.23096978
56SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23095997
57TBX3_20139965_ChIP-Seq_MESCs_Mouse1.23067589
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22865553
59ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.22542677
60SMAD4_21741376_ChIP-Seq_HESCs_Human1.21746751
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.20185044
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18042004
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17839182
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.17573923
65CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16669148
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.16206568
67E2F4_17652178_ChIP-ChIP_JURKAT_Human1.15573954
68SOX9_26525672_Chip-Seq_HEART_Mouse1.12017150
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11715655
70RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11704869
71CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11678169
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11569834
73* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11566721
74TP53_18474530_ChIP-ChIP_U2OS_Human1.11451995
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11135335
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11080882
77TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10013227
78BCAT_22108803_ChIP-Seq_LS180_Human1.09167602
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.06778448
80SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06501153
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05932979
82LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05425560
83SOX17_20123909_ChIP-Seq_XEN_Mouse1.03636038
84NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02507906
85SOX2_16153702_ChIP-ChIP_HESCs_Human0.98840707
86FLI1_27457419_Chip-Seq_LIVER_Mouse0.98752523
87PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98748015
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.98670498
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98580229
90NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.97909934
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97150448
92TP63_19390658_ChIP-ChIP_HaCaT_Human0.96928970
93GATA1_26923725_Chip-Seq_HPCs_Mouse0.94657689
94SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94118825
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.94016864
96EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93820235
97SMAD4_21741376_ChIP-Seq_EPCs_Human0.92072103
98TCF4_22108803_ChIP-Seq_LS180_Human0.91561222
99CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91189859
100FOXM1_23109430_ChIP-Seq_U2OS_Human0.90796650

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003890_abnormal_embryonic-extraembry3.17712778
2MP0003136_yellow_coat_color2.99962974
3MP0003941_abnormal_skin_development2.87075268
4MP0004272_abnormal_basement_membrane2.65972981
5MP0003123_paternal_imprinting2.54853373
6MP0009384_cardiac_valve_regurgitation2.28031248
7MP0003119_abnormal_digestive_system2.13057166
8MP0004215_abnormal_myocardial_fiber2.07994036
9MP0000372_irregular_coat_pigmentation2.04355166
10MP0000516_abnormal_urinary_system2.01656384
11MP0005367_renal/urinary_system_phenotyp2.01656384
12MP0003937_abnormal_limbs/digits/tail_de1.84523434
13MP0002163_abnormal_gland_morphology1.83521649
14MP0003283_abnormal_digestive_organ1.75076488
15MP0003385_abnormal_body_wall1.70136946
16MP0001661_extended_life_span1.67398234
17MP0005171_absent_coat_pigmentation1.63534638
18MP0009697_abnormal_copulation1.63402308
19MP0010030_abnormal_orbit_morphology1.61327887
20MP0000462_abnormal_digestive_system1.61320373
21MP0009250_abnormal_appendicular_skeleto1.59286315
22MP0002233_abnormal_nose_morphology1.58666363
23MP0003567_abnormal_fetal_cardiomyocyte1.56694010
24MP0005623_abnormal_meninges_morphology1.54811615
25MP0002938_white_spotting1.52278240
26MP0006054_spinal_hemorrhage1.49784498
27MP0004133_heterotaxia1.47139554
28MP0002102_abnormal_ear_morphology1.46617159
29MP0000537_abnormal_urethra_morphology1.45006461
30MP0000534_abnormal_ureter_morphology1.38950067
31MP0002254_reproductive_system_inflammat1.35732740
32MP0004957_abnormal_blastocyst_morpholog1.34109356
33MP0002084_abnormal_developmental_patter1.30753321
34MP0003935_abnormal_craniofacial_develop1.30543550
35MP0005330_cardiomyopathy1.28287809
36MP0001286_abnormal_eye_development1.27962376
37MP0002697_abnormal_eye_size1.27812313
38MP0009053_abnormal_anal_canal1.24691953
39MP0004145_abnormal_muscle_electrophysio1.21445150
40MP0000639_abnormal_adrenal_gland1.20319052
41MP0003195_calcinosis1.16693660
42MP0003755_abnormal_palate_morphology1.16558286
43MP0003942_abnormal_urinary_system1.14323572
44MP0001293_anophthalmia1.13779148
45MP0000428_abnormal_craniofacial_morphol1.12663026
46MP0000762_abnormal_tongue_morphology1.12426742
47MP0010368_abnormal_lymphatic_system1.09794406
48MP0005379_endocrine/exocrine_gland_phen1.09550686
49MP0002090_abnormal_vision1.09525592
50MP0003984_embryonic_growth_retardation1.09181714
51MP0002127_abnormal_cardiovascular_syste1.08569930
52MP0005380_embryogenesis_phenotype1.07820712
53MP0001672_abnormal_embryogenesis/_devel1.07820712
54MP0000049_abnormal_middle_ear1.06500272
55MP0004085_abnormal_heartbeat1.06217561
56MP0002088_abnormal_embryonic_growth/wei1.05127895
57MP0005187_abnormal_penis_morphology1.04314542
58MP0008932_abnormal_embryonic_tissue1.04265553
59MP0002972_abnormal_cardiac_muscle1.02410486
60MP0002085_abnormal_embryonic_tissue1.01869859
61MP0000647_abnormal_sebaceous_gland1.01788512
62MP0002111_abnormal_tail_morphology1.01474862
63MP0005408_hypopigmentation0.96468931
64MP0005197_abnormal_uvea_morphology0.95428890
65MP0006138_congestive_heart_failure0.95387779
66MP0010234_abnormal_vibrissa_follicle0.94706266
67MP0005085_abnormal_gallbladder_physiolo0.93350093
68MP0005253_abnormal_eye_physiology0.92002608
69MP0006072_abnormal_retinal_apoptosis0.91498026
70MP0010352_gastrointestinal_tract_polyps0.90408709
71MP0009672_abnormal_birth_weight0.87588310
72MP0009703_decreased_birth_body0.87472567
73MP0001879_abnormal_lymphatic_vessel0.87204626
74MP0008775_abnormal_heart_ventricle0.87074072
75MP0003693_abnormal_embryo_hatching0.85367917
76MP0000767_abnormal_smooth_muscle0.84403186
77MP0005257_abnormal_intraocular_pressure0.83073456
78MP0000751_myopathy0.83053070
79MP0003121_genomic_imprinting0.82979272
80MP0005620_abnormal_muscle_contractility0.81642943
81MP0005275_abnormal_skin_tensile0.81615026
82MP0004084_abnormal_cardiac_muscle0.81233578
83MP0000432_abnormal_head_morphology0.80961140
84MP0005391_vision/eye_phenotype0.80463655
85MP0003011_delayed_dark_adaptation0.79998174
86MP0001697_abnormal_embryo_size0.79980934
87MP0001730_embryonic_growth_arrest0.79674688
88MP0005508_abnormal_skeleton_morphology0.79493778
89MP0010630_abnormal_cardiac_muscle0.78979730
90MP0001324_abnormal_eye_pigmentation0.78581726
91MP0002092_abnormal_eye_morphology0.77852554
92MP0002909_abnormal_adrenal_gland0.77670591
93MP0002925_abnormal_cardiovascular_devel0.77644650
94MP0002160_abnormal_reproductive_system0.77446338
95MP0002638_abnormal_pupillary_reflex0.76594774
96MP0004197_abnormal_fetal_growth/weight/0.76358772
97MP0005248_abnormal_Harderian_gland0.75667522
98MP0001299_abnormal_eye_distance/0.75436496
99MP0004264_abnormal_extraembryonic_tissu0.74163546
100MP0002086_abnormal_extraembryonic_tissu0.73586774

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)3.93068243
2Hepatoblastoma (HP:0002884)3.38288594
3Metaphyseal dysplasia (HP:0100255)3.26794438
4Double outlet right ventricle (HP:0001719)3.08928222
5Congenital malformation of the right heart (HP:0011723)3.08928222
6Preaxial foot polydactyly (HP:0001841)3.02705149
7Bifid tongue (HP:0010297)2.89209992
8Short hallux (HP:0010109)2.74242754
9Myelomeningocele (HP:0002475)2.70625096
10Diastasis recti (HP:0001540)2.58774765
11Absent eyebrow (HP:0002223)2.52500731
12Aplasia/Hypoplasia of the hallux (HP:0008362)2.51330593
13Intestinal atresia (HP:0011100)2.49490925
14Hypoalphalipoproteinemia (HP:0003233)2.41542383
15Enlarged kidneys (HP:0000105)2.38828500
16Abnormal umbilical cord blood vessels (HP:0011403)2.35286567
17Single umbilical artery (HP:0001195)2.35286567
18Abnormality of the fetal cardiovascular system (HP:0010948)2.35286567
19Abnormality of the phalanges of the 2nd finger (HP:0009541)2.34123884
20Abnormality of the ischium (HP:0003174)2.32651996
21Adrenal hypoplasia (HP:0000835)2.26762233
22Short tibia (HP:0005736)2.23334503
23Coronal craniosynostosis (HP:0004440)2.22151211
24Transposition of the great arteries (HP:0001669)2.20760706
25Abnormal connection of the cardiac segments (HP:0011545)2.20760706
26Abnormal ventriculo-arterial connection (HP:0011563)2.20760706
27Right ventricular cardiomyopathy (HP:0011663)2.20277441
28Preauricular pit (HP:0004467)2.18252314
29Periauricular skin pits (HP:0100277)2.18252314
30Scotoma (HP:0000575)2.12586407
31Renal hypoplasia (HP:0000089)2.08326767
32Hypoglycemic seizures (HP:0002173)2.07137126
33Neoplasm of the adrenal cortex (HP:0100641)2.06996894
34Aplasia/Hypoplasia of the tibia (HP:0005772)2.05481800
35Disproportionate short-trunk short stature (HP:0003521)2.05340820
36Patchy hypopigmentation of hair (HP:0011365)2.05223330
37Aqueductal stenosis (HP:0002410)2.00923832
38White forelock (HP:0002211)2.00751842
39Ventricular tachycardia (HP:0004756)1.98976954
40Hypoplastic left heart (HP:0004383)1.98130857
41Median cleft lip (HP:0000161)1.96622874
42Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95574978
43Intrahepatic cholestasis (HP:0001406)1.93911320
44Hypoglycemic coma (HP:0001325)1.92973576
45Anophthalmia (HP:0000528)1.92068914
46Hyperglycinemia (HP:0002154)1.91884096
47Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.91336551
48Neonatal hypoglycemia (HP:0001998)1.90841014
49Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.90440414
50Neoplasm of the adrenal gland (HP:0100631)1.89546598
51Absent radius (HP:0003974)1.88099250
52Genital tract atresia (HP:0001827)1.87182535
53Esophageal atresia (HP:0002032)1.87016784
54Hypolipoproteinemia (HP:0010981)1.86023543
55Partial duplication of the phalanx of hand (HP:0009999)1.85206958
56Facial cleft (HP:0002006)1.84545226
57Osteomalacia (HP:0002749)1.83867029
58Gastrointestinal atresia (HP:0002589)1.82722083
59Hyperinsulinemic hypoglycemia (HP:0000825)1.79023131
60Abnormality of abdominal situs (HP:0011620)1.76626046
61Abdominal situs inversus (HP:0003363)1.76626046
62Cutaneous finger syndactyly (HP:0010554)1.76098520
63Overgrowth (HP:0001548)1.74927116
64Omphalocele (HP:0001539)1.74903225
65Abnormality of the calf musculature (HP:0001430)1.74662580
66Embryonal renal neoplasm (HP:0011794)1.72840233
67Epiphyseal dysplasia (HP:0002656)1.72839328
68Vaginal atresia (HP:0000148)1.72387386
69Bell-shaped thorax (HP:0001591)1.71557758
70Absent forearm bone (HP:0003953)1.71512966
71Aplasia involving forearm bones (HP:0009822)1.71512966
72Abnormality of the dental pulp (HP:0006479)1.70892919
73Nausea (HP:0002018)1.69997504
74Neoplasm of the small intestine (HP:0100833)1.68753722
75Taurodontia (HP:0000679)1.67430760
76Abnormality of permanent molar morphology (HP:0011071)1.67430760
77Abnormality of the dental root (HP:0006486)1.67430760
78Abnormal sex determination (HP:0012244)1.66862480
79Sex reversal (HP:0012245)1.66862480
80Anal stenosis (HP:0002025)1.66448708
81Gonadal dysgenesis (HP:0000133)1.65089429
82Ependymoma (HP:0002888)1.64899883
83Patent foramen ovale (HP:0001655)1.64228808
84Proximal tubulopathy (HP:0000114)1.60665095
85Vertebral clefting (HP:0008428)1.59640701
86Hypoplasia of the ulna (HP:0003022)1.59496428
87Papillary thyroid carcinoma (HP:0002895)1.59268424
88Abnormal biliary tract morphology (HP:0012440)1.59232211
89Ectopic anus (HP:0004397)1.58521843
90Septo-optic dysplasia (HP:0100842)1.57661282
91Abnormal vertebral ossification (HP:0100569)1.57478890
92Abnormality of the middle phalanges of the toes (HP:0010183)1.56457589
93Skin pits (HP:0100276)1.55923243
94Colon cancer (HP:0003003)1.55829760
95Maternal diabetes (HP:0009800)1.55635475
96Aplasia involving bones of the extremities (HP:0009825)1.55037867
97Aplasia involving bones of the upper limbs (HP:0009823)1.55037867
98Aplasia of the phalanges of the hand (HP:0009802)1.55037867
99Abnormal auditory evoked potentials (HP:0006958)1.54257693
100Missing ribs (HP:0000921)1.53532736

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.18912219
2PNCK3.10888718
3PBK2.82555005
4ACVR1B2.72601614
5OBSCN2.69837726
6STK38L2.60092986
7TAF12.45224423
8WEE12.40794062
9FRK2.28778193
10LATS12.24752008
11STK242.05782761
12ERBB41.99855680
13MAP3K121.95101912
14FLT31.84555640
15BMPR1B1.80066697
16PDK21.78952503
17LATS21.76696365
18TSSK61.76530169
19PKN21.76511352
20TRIM281.74477744
21STK391.73430289
22MST41.65469782
23MET1.63341242
24FGFR21.62374621
25PDGFRA1.59833543
26STK31.58298365
27DMPK1.56892750
28SRPK11.53128409
29PLK31.45469671
30CDC71.41190436
31TNIK1.39762699
32NUAK11.33958975
33BRSK21.30337257
34MKNK21.25949425
35PLK41.25360241
36EIF2AK31.22911082
37MAP3K101.21987427
38CASK1.20849998
39NEK11.20418932
40MST1R1.16676743
41TTK1.16632151
42BCR1.12844009
43FGFR11.01651280
44WNK30.98079742
45MKNK10.97529290
46NTRK30.95264937
47SIK30.91168794
48DYRK30.89358004
49PTK20.86758793
50PLK10.86281378
51EPHB20.85751869
52KSR10.83857065
53MAP3K20.82575140
54NEK20.82205936
55EPHA20.81003226
56MINK10.79489054
57ERBB30.79394397
58WNK40.77884553
59BRSK10.77305059
60TGFBR10.76341751
61MAPK150.74811511
62PIK3CA0.74748727
63PLK20.72178902
64NLK0.70989409
65PINK10.68104784
66RAF10.67319651
67PAK30.63250252
68ROCK10.63047971
69CAMK2D0.62969254
70MYLK0.61955142
71VRK10.61615259
72BRAF0.57013088
73NEK90.54603519
74MAP3K80.54169479
75ABL20.53247505
76GRK10.52165859
77PDGFRB0.48257025
78LMTK20.48174503
79CSNK1G10.46552433
80YES10.46487552
81CSNK1G20.46443302
82PRKCE0.45912625
83MAP3K90.45468967
84AKT30.44140343
85NTRK10.40585276
86CAMK1G0.39470465
87BUB10.38836711
88PAK40.37959291
89CDK30.37457823
90OXSR10.37269503
91TIE10.37088014
92MELK0.36762116
93BRD40.36714035
94VRK20.33630391
95STK100.33589942
96NEK60.30519855
97ATM0.29879745
98PRKCG0.29786624
99RPS6KB10.29618944
100CAMK2A0.27566483

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid elongation_Homo sapiens_hsa000622.38997232
2Propanoate metabolism_Homo sapiens_hsa006402.18032096
3TGF-beta signaling pathway_Homo sapiens_hsa043502.05000387
4Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.01256697
5Steroid biosynthesis_Homo sapiens_hsa001001.96195342
6Pyruvate metabolism_Homo sapiens_hsa006201.96048720
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.90095625
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.89366397
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.80528001
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.80154934
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.72723567
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62847198
13Hippo signaling pathway_Homo sapiens_hsa043901.59564923
14Sulfur metabolism_Homo sapiens_hsa009201.59173548
15Protein export_Homo sapiens_hsa030601.58706681
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.56135899
17Fatty acid degradation_Homo sapiens_hsa000711.51147951
18Basal cell carcinoma_Homo sapiens_hsa052171.50800586
19Folate biosynthesis_Homo sapiens_hsa007901.50501718
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.48476049
21ECM-receptor interaction_Homo sapiens_hsa045121.42540216
22Adherens junction_Homo sapiens_hsa045201.37970377
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.30505578
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.30220233
25Mismatch repair_Homo sapiens_hsa034301.29454329
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26568957
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.26261365
28Proteasome_Homo sapiens_hsa030501.24717503
29Basal transcription factors_Homo sapiens_hsa030221.24477829
30Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.24022117
31Retinol metabolism_Homo sapiens_hsa008301.17539931
32Sulfur relay system_Homo sapiens_hsa041221.17201184
33Fatty acid metabolism_Homo sapiens_hsa012121.16115163
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.15929849
35Wnt signaling pathway_Homo sapiens_hsa043101.15131348
36Non-homologous end-joining_Homo sapiens_hsa034501.14302965
37Primary bile acid biosynthesis_Homo sapiens_hsa001201.07405251
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.07389221
39Maturity onset diabetes of the young_Homo sapiens_hsa049501.07231475
40Chemical carcinogenesis_Homo sapiens_hsa052041.02717076
41Vitamin B6 metabolism_Homo sapiens_hsa007501.01931492
42Hedgehog signaling pathway_Homo sapiens_hsa043400.99762112
43Cell cycle_Homo sapiens_hsa041100.98100747
44One carbon pool by folate_Homo sapiens_hsa006700.96883650
45beta-Alanine metabolism_Homo sapiens_hsa004100.96511007
46Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96309243
47Selenocompound metabolism_Homo sapiens_hsa004500.96191845
48Fanconi anemia pathway_Homo sapiens_hsa034600.95986984
49Tight junction_Homo sapiens_hsa045300.94196123
50Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92859594
51Histidine metabolism_Homo sapiens_hsa003400.91297583
52Dilated cardiomyopathy_Homo sapiens_hsa054140.89105198
53Glutathione metabolism_Homo sapiens_hsa004800.88397666
54Melanogenesis_Homo sapiens_hsa049160.86897802
55Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86214700
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.84520199
57Peroxisome_Homo sapiens_hsa041460.84389851
58Carbon metabolism_Homo sapiens_hsa012000.83338854
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.77986460
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77791837
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.77712116
62Butanoate metabolism_Homo sapiens_hsa006500.76745911
63Arginine and proline metabolism_Homo sapiens_hsa003300.72408913
64Starch and sucrose metabolism_Homo sapiens_hsa005000.71946220
65Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69113183
66Oocyte meiosis_Homo sapiens_hsa041140.69034488
67Cardiac muscle contraction_Homo sapiens_hsa042600.67246917
68Focal adhesion_Homo sapiens_hsa045100.67123938
69Huntingtons disease_Homo sapiens_hsa050160.66838619
70RNA degradation_Homo sapiens_hsa030180.66188518
71RNA transport_Homo sapiens_hsa030130.66078462
72Biosynthesis of amino acids_Homo sapiens_hsa012300.64872858
73Parkinsons disease_Homo sapiens_hsa050120.64223108
74Tyrosine metabolism_Homo sapiens_hsa003500.62287926
75Homologous recombination_Homo sapiens_hsa034400.62272509
76PPAR signaling pathway_Homo sapiens_hsa033200.62179158
77Fat digestion and absorption_Homo sapiens_hsa049750.61648259
78Oxidative phosphorylation_Homo sapiens_hsa001900.59663477
79Nucleotide excision repair_Homo sapiens_hsa034200.58724982
80Caffeine metabolism_Homo sapiens_hsa002320.58504079
81Protein digestion and absorption_Homo sapiens_hsa049740.55835635
82Small cell lung cancer_Homo sapiens_hsa052220.55708976
83Tryptophan metabolism_Homo sapiens_hsa003800.55371330
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.54340218
85Thyroid cancer_Homo sapiens_hsa052160.53617219
86Proteoglycans in cancer_Homo sapiens_hsa052050.52776174
87Lysine degradation_Homo sapiens_hsa003100.52451239
88DNA replication_Homo sapiens_hsa030300.52162332
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51168675
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.50936080
91Phenylalanine metabolism_Homo sapiens_hsa003600.50647832
92Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.50208550
93Metabolic pathways_Homo sapiens_hsa011000.48801673
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.46853531
95p53 signaling pathway_Homo sapiens_hsa041150.46641857
96Nitrogen metabolism_Homo sapiens_hsa009100.46459100
97Pathways in cancer_Homo sapiens_hsa052000.44611958
98Purine metabolism_Homo sapiens_hsa002300.44011117
99Circadian rhythm_Homo sapiens_hsa047100.43397966
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.42291207

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