TMEM134

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.33522016
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.33522016
3behavioral response to nicotine (GO:0035095)4.21616042
4protein complex biogenesis (GO:0070271)4.21033370
5antigen processing and presentation of endogenous antigen (GO:0019883)4.08083021
6mitochondrial respiratory chain complex I assembly (GO:0032981)4.01114889
7NADH dehydrogenase complex assembly (GO:0010257)4.01114889
8mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.01114889
9valine metabolic process (GO:0006573)3.92783056
10RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.84284842
11tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.84284842
12ribosomal small subunit assembly (GO:0000028)3.80674161
13mitochondrial respiratory chain complex assembly (GO:0033108)3.77416402
14viral transcription (GO:0019083)3.77000859
15preassembly of GPI anchor in ER membrane (GO:0016254)3.72209047
16SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.59357358
17translational termination (GO:0006415)3.55382000
18fucose catabolic process (GO:0019317)3.53191623
19L-fucose metabolic process (GO:0042354)3.53191623
20L-fucose catabolic process (GO:0042355)3.53191623
21protein targeting to ER (GO:0045047)3.52381423
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51486051
23cytidine metabolic process (GO:0046087)3.50518021
24cytidine catabolic process (GO:0006216)3.50518021
25cytidine deamination (GO:0009972)3.50518021
26cotranslational protein targeting to membrane (GO:0006613)3.49454317
27ubiquinone biosynthetic process (GO:0006744)3.49062604
28cytochrome complex assembly (GO:0017004)3.46222985
29tryptophan catabolic process (GO:0006569)3.43122266
30indole-containing compound catabolic process (GO:0042436)3.43122266
31indolalkylamine catabolic process (GO:0046218)3.43122266
32respiratory chain complex IV assembly (GO:0008535)3.38277264
33protein localization to endoplasmic reticulum (GO:0070972)3.36240434
34signal peptide processing (GO:0006465)3.35856536
35establishment of protein localization to endoplasmic reticulum (GO:0072599)3.33302027
36positive regulation of defense response to virus by host (GO:0002230)3.32703316
37water-soluble vitamin biosynthetic process (GO:0042364)3.32515343
38cornea development in camera-type eye (GO:0061303)3.29446480
39positive regulation of prostaglandin secretion (GO:0032308)3.27350778
40metallo-sulfur cluster assembly (GO:0031163)3.27166904
41iron-sulfur cluster assembly (GO:0016226)3.27166904
42ATP synthesis coupled proton transport (GO:0015986)3.22503707
43energy coupled proton transport, down electrochemical gradient (GO:0015985)3.22503707
44axoneme assembly (GO:0035082)3.20403815
45platelet dense granule organization (GO:0060155)3.19012671
46pseudouridine synthesis (GO:0001522)3.17224034
47protein-cofactor linkage (GO:0018065)3.14252716
48kynurenine metabolic process (GO:0070189)3.13702889
49indolalkylamine metabolic process (GO:0006586)3.13280030
50epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13179386
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.12122377
52mannosylation (GO:0097502)3.11370425
53cellular ketone body metabolic process (GO:0046950)3.08569227
54regulation of sequestering of triglyceride (GO:0010889)3.07863839
55electron transport chain (GO:0022900)3.06992626
56translational elongation (GO:0006414)3.02440105
57ubiquinone metabolic process (GO:0006743)3.01433587
58mitochondrial calcium ion transport (GO:0006851)3.00997989
59low-density lipoprotein particle clearance (GO:0034383)2.99095096
60respiratory electron transport chain (GO:0022904)2.97648393
61positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92393783
62base-excision repair, AP site formation (GO:0006285)2.92325307
63ribosomal small subunit biogenesis (GO:0042274)2.91522029
64establishment of protein localization to mitochondrial membrane (GO:0090151)2.91011255
65L-phenylalanine metabolic process (GO:0006558)2.90891060
66erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.90891060
67positive regulation of fatty acid transport (GO:2000193)2.90004338
68tryptophan metabolic process (GO:0006568)2.89423975
69cellular response to zinc ion (GO:0071294)2.88025236
70quinone biosynthetic process (GO:1901663)2.86967206
71GPI anchor metabolic process (GO:0006505)2.85485279
72heme biosynthetic process (GO:0006783)2.84685958
73fatty acid beta-oxidation (GO:0006635)2.84409233
74pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.83811153
75negative regulation of telomere maintenance (GO:0032205)2.83601394
76Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83277413
77regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.82992415
78pyrimidine ribonucleoside catabolic process (GO:0046133)2.82053279
79piRNA metabolic process (GO:0034587)2.81093070
80positive regulation of icosanoid secretion (GO:0032305)2.80418761
81mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79079131
82detection of light stimulus involved in sensory perception (GO:0050962)2.78060874
83detection of light stimulus involved in visual perception (GO:0050908)2.78060874
84viral life cycle (GO:0019058)2.77873092
85GPI anchor biosynthetic process (GO:0006506)2.73461035
86branched-chain amino acid metabolic process (GO:0009081)2.72389897
87epithelial cilium movement (GO:0003351)2.72015170
88ketone body metabolic process (GO:1902224)2.71962857
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.71017035
90L-phenylalanine catabolic process (GO:0006559)2.71017035
91amine catabolic process (GO:0009310)2.70910445
92cellular biogenic amine catabolic process (GO:0042402)2.70910445
93L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.70536250
94autophagic vacuole fusion (GO:0000046)2.68723417
95chaperone-mediated protein transport (GO:0072321)2.67238718
96detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66995935
97regulation of triglyceride catabolic process (GO:0010896)2.66876381
98response to pheromone (GO:0019236)2.66700434
99regulation of cilium movement (GO:0003352)2.64212243
100branched-chain amino acid catabolic process (GO:0009083)2.63938921
101C-terminal protein lipidation (GO:0006501)2.62275486
102peptidyl-histidine modification (GO:0018202)2.58936171
103heme metabolic process (GO:0042168)2.58385595
104multicellular organism reproduction (GO:0032504)2.56656576
105fatty acid oxidation (GO:0019395)2.55591163
106transcription elongation from RNA polymerase III promoter (GO:0006385)2.54872953
107termination of RNA polymerase III transcription (GO:0006386)2.54872953
108regulation of metalloenzyme activity (GO:0048552)2.54039971
109triglyceride catabolic process (GO:0019433)2.53482733
110fatty acid catabolic process (GO:0009062)2.52998985
111fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.51466375
112GTP biosynthetic process (GO:0006183)2.49730288
113lipid oxidation (GO:0034440)2.49574479
114arginine metabolic process (GO:0006525)2.47899898
115NAD biosynthetic process (GO:0009435)2.47274067
116adenosine metabolic process (GO:0046085)2.46898503
117cellular protein complex disassembly (GO:0043624)2.46674715
118protein targeting to membrane (GO:0006612)2.45700493
119proton transport (GO:0015992)2.45425863
120negative regulation of T cell differentiation in thymus (GO:0033085)2.45238730
121deoxyribonucleotide catabolic process (GO:0009264)2.45069532
122sulfur amino acid catabolic process (GO:0000098)2.44894169
123sequestering of actin monomers (GO:0042989)2.44113301
124organelle membrane fusion (GO:0090174)2.43866957
125positive regulation of protein homodimerization activity (GO:0090073)2.42757790
126tRNA processing (GO:0008033)2.42447137
127hydrogen ion transmembrane transport (GO:1902600)2.42198412
128regulation of cholesterol storage (GO:0010885)2.42164860
129arginine catabolic process (GO:0006527)2.41470630
130estrogen biosynthetic process (GO:0006703)2.40803848
131DNA methylation involved in gamete generation (GO:0043046)2.40166460
132hydrogen transport (GO:0006818)2.39662513
133negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.39193760
134tRNA modification (GO:0006400)2.39006709
135positive regulation of triglyceride metabolic process (GO:0090208)2.38316227
136L-methionine salvage (GO:0071267)2.36104781
137L-methionine biosynthetic process (GO:0071265)2.36104781
138amino acid salvage (GO:0043102)2.36104781
139purinergic nucleotide receptor signaling pathway (GO:0035590)2.35134795
140pentose-phosphate shunt (GO:0006098)2.34873864
141regulation of defense response to virus by host (GO:0050691)2.34115147
142nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.33841785
143protein neddylation (GO:0045116)2.33125861
144C-terminal protein amino acid modification (GO:0018410)2.32863656
145desmosome organization (GO:0002934)2.30329836
146aldehyde catabolic process (GO:0046185)2.29312838
147positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.27034112
148regulation of superoxide anion generation (GO:0032928)2.25741262
149translational initiation (GO:0006413)2.25290857
150regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.25244321
151response to type I interferon (GO:0034340)2.25183140
152plasma lipoprotein particle clearance (GO:0034381)2.24445964
153positive regulation of lipoprotein lipase activity (GO:0051006)2.24098642
154positive regulation of triglyceride lipase activity (GO:0061365)2.24098642
155cysteine metabolic process (GO:0006534)2.23091154
156negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.22690168
157tricarboxylic acid metabolic process (GO:0072350)2.22536110
158ethanol oxidation (GO:0006069)2.22346577
159hydrogen peroxide biosynthetic process (GO:0050665)2.22227154
160negative regulation of lipid storage (GO:0010888)2.22193212
161cellular response to type I interferon (GO:0071357)2.21929520
162type I interferon signaling pathway (GO:0060337)2.21929520
163positive regulation of gamma-delta T cell activation (GO:0046645)2.21746087
164acylglycerol catabolic process (GO:0046464)2.20364853
165neutral lipid catabolic process (GO:0046461)2.20364853
166brown fat cell differentiation (GO:0050873)2.20101405
167glyoxylate metabolic process (GO:0046487)2.19260805
168negative regulation of protein autophosphorylation (GO:0031953)2.19053813
169response to interferon-beta (GO:0035456)2.18413444
170amyloid precursor protein catabolic process (GO:0042987)2.17499318
171regulation of cholesterol metabolic process (GO:0090181)2.15987750
172aromatic amino acid family catabolic process (GO:0009074)2.15952126
173triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.15069014
174leukocyte aggregation (GO:0070486)2.14690399
175NADPH regeneration (GO:0006740)2.14655350
176monocarboxylic acid catabolic process (GO:0072329)2.14278897
177regulation of triglyceride metabolic process (GO:0090207)2.14231845
178ethanol metabolic process (GO:0006067)2.12074552
179negative regulation of phagocytosis (GO:0050765)2.11679567
180regulation of cholesterol esterification (GO:0010872)2.11425000
181neutrophil activation involved in immune response (GO:0002283)2.10670494
182positive regulation of lipid catabolic process (GO:0050996)2.10615826
183positive regulation of fatty acid oxidation (GO:0046321)2.10253861
184porphyrin-containing compound biosynthetic process (GO:0006779)2.08962920
185DNA deamination (GO:0045006)2.08728286
186transcytosis (GO:0045056)2.08077841
187alpha-linolenic acid metabolic process (GO:0036109)2.06761748
188positive regulation of fatty acid beta-oxidation (GO:0032000)2.06200228
189biotin metabolic process (GO:0006768)2.05893677
1902-oxoglutarate metabolic process (GO:0006103)2.05015602
191antigen processing and presentation via MHC class Ib (GO:0002475)2.04260801
192regulation of superoxide metabolic process (GO:0090322)2.03740753
193pentose metabolic process (GO:0019321)2.02688667
194reactive oxygen species biosynthetic process (GO:1903409)2.02367889
195protein retention in ER lumen (GO:0006621)2.01919309
196primary alcohol catabolic process (GO:0034310)2.01863840
197xenobiotic catabolic process (GO:0042178)2.01806708

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.00212801
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.90741034
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.58585222
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.49899010
5ZNF274_21170338_ChIP-Seq_K562_Hela3.45535816
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.24273584
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.79412498
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.75313197
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.72289610
10VDR_22108803_ChIP-Seq_LS180_Human2.37287761
11* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.34697199
12EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33994032
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.31064509
14EZH2_22144423_ChIP-Seq_EOC_Human2.21256734
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.18842737
16IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18730982
17TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08716138
18RARG_19884340_ChIP-ChIP_MEFs_Mouse1.99916569
19EGR1_23403033_ChIP-Seq_LIVER_Mouse1.99136150
20LXR_22158963_ChIP-Seq_LIVER_Mouse1.95886822
21EST1_17652178_ChIP-ChIP_JURKAT_Human1.93575147
22EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.92186093
23CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.90131605
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.89417838
25ETS1_20019798_ChIP-Seq_JURKAT_Human1.86560895
26IRF8_21731497_ChIP-ChIP_J774_Mouse1.85450048
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84162895
28ERA_21632823_ChIP-Seq_H3396_Human1.82550815
29* VDR_23849224_ChIP-Seq_CD4+_Human1.82037291
30RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.79368489
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.77741024
32NOTCH1_21737748_ChIP-Seq_TLL_Human1.77329789
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77068558
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76139118
35MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.75968553
36VDR_21846776_ChIP-Seq_THP-1_Human1.75163376
37STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.74829285
38TP53_22573176_ChIP-Seq_HFKS_Human1.74609568
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.74137157
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.70140844
41RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66582652
42SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64027636
43FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62374422
44STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61258740
45RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59373096
46GATA3_21878914_ChIP-Seq_MCF-7_Human1.58889546
47FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58430332
48E2F1_20622854_ChIP-Seq_HELA_Human1.57822714
49* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57821955
50MAF_26560356_Chip-Seq_TH1_Human1.56313632
51TAF2_19829295_ChIP-Seq_ESCs_Human1.55115307
52NANOG_20526341_ChIP-Seq_ESCs_Human1.54100706
53MYB_21317192_ChIP-Seq_ERMYB_Mouse1.51676184
54AR_20517297_ChIP-Seq_VCAP_Human1.49715132
55IRF1_19129219_ChIP-ChIP_H3396_Human1.49641026
56FOXA1_25329375_ChIP-Seq_VCAP_Human1.49495413
57FOXA1_27270436_Chip-Seq_PROSTATE_Human1.49495413
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.48708527
59CLOCK_20551151_ChIP-Seq_293T_Human1.47652649
60BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43003951
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.42492909
62CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.41728600
63P300_27268052_Chip-Seq_Bcells_Human1.40883528
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.40854735
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40460512
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39842213
67P68_20966046_ChIP-Seq_HELA_Human1.39411398
68* P53_21459846_ChIP-Seq_SAOS-2_Human1.38926380
69STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38054705
70PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.38010234
71MYC_19829295_ChIP-Seq_ESCs_Human1.36772238
72NCOR_22424771_ChIP-Seq_293T_Human1.35629134
73MYC_18940864_ChIP-ChIP_HL60_Human1.35530757
74PHF8_20622854_ChIP-Seq_HELA_Human1.35470194
75* FOXP3_21729870_ChIP-Seq_TREG_Human1.34740401
76VDR_24763502_ChIP-Seq_THP-1_Human1.33907256
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.33399455
78OCT4_20526341_ChIP-Seq_ESCs_Human1.32985449
79TRIM28_21343339_ChIP-Seq_HEK293_Human1.32347072
80PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.31780313
81* CTCF_20526341_ChIP-Seq_ESCs_Human1.31542491
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30896295
83ZNF263_19887448_ChIP-Seq_K562_Human1.30062404
84TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29599005
85P63_26484246_Chip-Seq_KERATINOCYTES_Human1.29451266
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28763599
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.28734776
88ELF1_20517297_ChIP-Seq_JURKAT_Human1.28314659
89SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28285328
90SPI1_23547873_ChIP-Seq_NB4_Human1.28028642
91IRF8_27001747_Chip-Seq_BMDM_Mouse1.25928650
92RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.25041597
93STAT1_20625510_ChIP-Seq_HELA_Human1.24980328
94* RAC3_21632823_ChIP-Seq_H3396_Human1.24316480
95* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.23715403
96MYB_26560356_Chip-Seq_TH2_Human1.22825921
97MYC_22102868_ChIP-Seq_BL_Human1.22021262
98GABP_17652178_ChIP-ChIP_JURKAT_Human1.21495230
99LXR_22292898_ChIP-Seq_THP-1_Human1.21227225
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.20623182
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.19943204
102MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19651142
103HOXB7_26014856_ChIP-Seq_BT474_Human1.19261351
104UTX_26944678_Chip-Seq_JUKART_Human1.19143653
105ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18489298
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17696504
107IGF1R_20145208_ChIP-Seq_DFB_Human1.17625088
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17403269
109ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17255125
110EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.16915466
111* GABP_19822575_ChIP-Seq_HepG2_Human1.16672097
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16510275
113GATA3_26560356_Chip-Seq_TH2_Human1.15740521
114* MAF_26560356_Chip-Seq_TH2_Human1.15645976
115RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.15144611
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14239285
117* YY1_21170310_ChIP-Seq_MESCs_Mouse1.13835095
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.13068145
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12772293
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.12483409
121SCL_19346495_ChIP-Seq_HPC-7_Human1.12348551
122ERG_20517297_ChIP-Seq_VCAP_Human1.12281035
123* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12162739
124FOXH1_21741376_ChIP-Seq_ESCs_Human1.11052635
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.10437553
126LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10347366
127CTCF_26484167_Chip-Seq_Bcells_Mouse1.10263787
128THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08869594
129GATA1_22025678_ChIP-Seq_K562_Human1.07765548
130CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06906365
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05829061
132ER_23166858_ChIP-Seq_MCF-7_Human1.05528388
133CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.04755229
134MYB_26560356_Chip-Seq_TH1_Human1.04635450
135FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04462123
136SA1_27219007_Chip-Seq_Bcells_Human1.04304485
137CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04119310
138SRF_21415370_ChIP-Seq_HL-1_Mouse1.03871613
139SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03477061
140FOXP1_21924763_ChIP-Seq_HESCs_Human1.03186459
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.03104957
142SOX2_21211035_ChIP-Seq_LN229_Human1.02970373
143STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00993345
144PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99999266
145* RACK7_27058665_Chip-Seq_MCF-7_Human0.99901291
146MYC_18555785_ChIP-Seq_MESCs_Mouse0.99653456
147FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99457911
148CTBP2_25329375_ChIP-Seq_LNCAP_Human0.98316995
149CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.97930646
150* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97784867
151BCL6_27268052_Chip-Seq_Bcells_Human0.97267871
152PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.97225755
153* TET1_21451524_ChIP-Seq_MESCs_Mouse0.97161260
154LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.96887323
155ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.96863662
156KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.95705226
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.95672569
158CIITA_25753668_ChIP-Seq_RAJI_Human0.95399554
159TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95307359
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95303571
161NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95077136
162SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94872724
163BCOR_27268052_Chip-Seq_Bcells_Human0.94496339
164CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94157551
165DCP1A_22483619_ChIP-Seq_HELA_Human0.93708622
166MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93656569
167P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.93317942
168AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93306411
169* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.93237099
170CREB1_15753290_ChIP-ChIP_HEK293T_Human0.92717583
171PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92613178
172TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.92405423
173EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.91776161
174KDM5A_27292631_Chip-Seq_BREAST_Human0.91422400
175* ATF3_27146783_Chip-Seq_COLON_Human0.90918356
176FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.90258501
177RUNX_20019798_ChIP-Seq_JUKART_Human0.89429488

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002653_abnormal_ependyma_morphology3.16367363
2MP0003011_delayed_dark_adaptation2.52494491
3MP0001968_abnormal_touch/_nociception2.52267443
4MP0001835_abnormal_antigen_presentation2.50181437
5MP0002139_abnormal_hepatobiliary_system2.50003905
6MP0005645_abnormal_hypothalamus_physiol2.43123659
7MP0000685_abnormal_immune_system2.41440942
8MP0002736_abnormal_nociception_after2.30920964
9MP0003724_increased_susceptibility_to2.23120555
10MP0003191_abnormal_cellular_cholesterol2.20864269
11MP0002876_abnormal_thyroid_physiology2.15882955
12MP0008872_abnormal_physiological_respon2.14727014
13MP0009785_altered_susceptibility_to2.13905669
14MP0003186_abnormal_redox_activity2.08889789
15MP0003806_abnormal_nucleotide_metabolis2.08113349
16MP0005360_urolithiasis2.07781570
17MP0006292_abnormal_olfactory_placode2.06889011
18MP0003436_decreased_susceptibility_to1.98721847
19MP0005551_abnormal_eye_electrophysiolog1.96479198
20MP0002638_abnormal_pupillary_reflex1.93695162
21MP0001873_stomach_inflammation1.92083316
22MP0001986_abnormal_taste_sensitivity1.88575399
23MP0003136_yellow_coat_color1.88477013
24MP0005670_abnormal_white_adipose1.87889650
25MP0005387_immune_system_phenotype1.87086825
26MP0001790_abnormal_immune_system1.87086825
27MP0005075_abnormal_melanosome_morpholog1.86897480
28MP0009840_abnormal_foam_cell1.85136688
29MP0005365_abnormal_bile_salt1.79820134
30MP0002166_altered_tumor_susceptibility1.78587595
31MP0008438_abnormal_cutaneous_collagen1.78133984
32MP0004145_abnormal_muscle_electrophysio1.72242687
33MP0004043_abnormal_pH_regulation1.71602843
34MP0008877_abnormal_DNA_methylation1.70424807
35MP0005377_hearing/vestibular/ear_phenot1.69857953
36MP0003878_abnormal_ear_physiology1.69857953
37MP0004147_increased_porphyrin_level1.68944663
38MP0000372_irregular_coat_pigmentation1.67670386
39MP0001919_abnormal_reproductive_system1.67221548
40MP0002277_abnormal_respiratory_mucosa1.65835048
41MP0005025_abnormal_response_to1.65247953
42MP0005671_abnormal_response_to1.64082053
43MP0002148_abnormal_hypersensitivity_rea1.63146880
44MP0002138_abnormal_hepatobiliary_system1.61757902
45MP0002102_abnormal_ear_morphology1.60874258
46MP0005000_abnormal_immune_tolerance1.57636882
47MP0005451_abnormal_body_composition1.56650986
48MP0004185_abnormal_adipocyte_glucose1.53852848
49MP0005275_abnormal_skin_tensile1.51079553
50MP0001853_heart_inflammation1.50978613
51MP0004142_abnormal_muscle_tone1.50045649
52MP0005666_abnormal_adipose_tissue1.49705634
53MP0003763_abnormal_thymus_physiology1.49663025
54MP0001800_abnormal_humoral_immune1.49603149
55MP0005083_abnormal_biliary_tract1.47567601
56MP0005646_abnormal_pituitary_gland1.46285304
57MP0002837_dystrophic_cardiac_calcinosis1.45669835
58MP0006072_abnormal_retinal_apoptosis1.45358356
59MP0005389_reproductive_system_phenotype1.44921713
60MP0008789_abnormal_olfactory_epithelium1.44103995
61MP0001905_abnormal_dopamine_level1.41791032
62MP0004885_abnormal_endolymph1.41277179
63MP0002234_abnormal_pharynx_morphology1.40824318
64MP0004133_heterotaxia1.40802284
65MP0002006_tumorigenesis1.38681036
66MP0005085_abnormal_gallbladder_physiolo1.37617015
67MP0005174_abnormal_tail_pigmentation1.37319356
68MP0002452_abnormal_antigen_presenting1.37190321
69MP0002419_abnormal_innate_immunity1.35474480
70MP0005253_abnormal_eye_physiology1.34852505
71MP0004947_skin_inflammation1.33983543
72MP0002796_impaired_skin_barrier1.33509970
73MP0002723_abnormal_immune_serum1.33065244
74MP0000858_altered_metastatic_potential1.32961284
75MP0009379_abnormal_foot_pigmentation1.32865184
76MP0003705_abnormal_hypodermis_morpholog1.32276421
77MP0001764_abnormal_homeostasis1.31164325
78MP0004130_abnormal_muscle_cell1.29973807
79MP0005058_abnormal_lysosome_morphology1.29805672
80MP0003656_abnormal_erythrocyte_physiolo1.28942873
81MP0003787_abnormal_imprinting1.28048223
82MP0003195_calcinosis1.28036012
83MP0006082_CNS_inflammation1.27486128
84MP0001485_abnormal_pinna_reflex1.26319777
85MP0009643_abnormal_urine_homeostasis1.25623355
86MP0008995_early_reproductive_senescence1.25063578
87MP0002420_abnormal_adaptive_immunity1.24646862
88MP0001819_abnormal_immune_cell1.24288845
89MP0005375_adipose_tissue_phenotype1.22526129
90MP0002933_joint_inflammation1.22524035
91MP0001666_abnormal_nutrient_absorption1.22476030
92MP0000343_altered_response_to1.22281089
93MP0001501_abnormal_sleep_pattern1.21276219
94MP0002405_respiratory_system_inflammati1.21254247
95MP0010155_abnormal_intestine_physiology1.21076843
96MP0001845_abnormal_inflammatory_respons1.20260161
97MP0002160_abnormal_reproductive_system1.20172313
98MP0000609_abnormal_liver_physiology1.19514038
99MP0008469_abnormal_protein_level1.19467589
100MP0003303_peritoneal_inflammation1.19158477
101MP0010329_abnormal_lipoprotein_level1.18632028
102MP0008875_abnormal_xenobiotic_pharmacok1.18473454
103MP0001533_abnormal_skeleton_physiology1.17883721
104MP0009333_abnormal_splenocyte_physiolog1.17188403
105MP0009745_abnormal_behavioral_response1.14932471
106MP0005332_abnormal_amino_acid1.14431998
107MP0003646_muscle_fatigue1.14328738
108MP0003453_abnormal_keratinocyte_physiol1.13760277
109MP0002877_abnormal_melanocyte_morpholog1.13557208
110MP0001879_abnormal_lymphatic_vessel1.11663871
111MP0006036_abnormal_mitochondrial_physio1.10953607
112MP0002060_abnormal_skin_morphology1.10613680
113MP0003828_pulmonary_edema1.10358649
114MP0003300_gastrointestinal_ulcer1.09326584
115MP0005319_abnormal_enzyme/_coenzyme1.09005649
116MP0000538_abnormal_urinary_bladder1.08038352
117MP0000749_muscle_degeneration1.07814401
118MP0005410_abnormal_fertilization1.07432756
119MP0002938_white_spotting1.07365010
120MP0000013_abnormal_adipose_tissue1.06164746
121MP0000427_abnormal_hair_cycle1.04042785
122MP0006276_abnormal_autonomic_nervous1.03970006
123MP0005464_abnormal_platelet_physiology1.03553345
124MP0002118_abnormal_lipid_homeostasis1.03068876
125MP0001502_abnormal_circadian_rhythm1.01460486
126MP0006054_spinal_hemorrhage1.01374792
127MP0010386_abnormal_urinary_bladder1.00718389
128MP0004742_abnormal_vestibular_system0.99695071
129MP0000631_abnormal_neuroendocrine_gland0.99472533
130MP0002971_abnormal_brown_adipose0.98585759
131MP0005501_abnormal_skin_physiology0.97579931
132MP0005584_abnormal_enzyme/coenzyme_acti0.97576470
133MP0009763_increased_sensitivity_to0.97338397
134MP0000716_abnormal_immune_system0.97032876
135MP0002272_abnormal_nervous_system0.96209825
136MP0003252_abnormal_bile_duct0.92953159
137MP0002398_abnormal_bone_marrow0.92841802
138MP0005023_abnormal_wound_healing0.91813459
139MP0000003_abnormal_adipose_tissue0.91060720
140MP0009764_decreased_sensitivity_to0.91045746
141MP0002095_abnormal_skin_pigmentation0.90891205
142MP0000689_abnormal_spleen_morphology0.90891145
143MP0001663_abnormal_digestive_system0.90825578
144MP0003786_premature_aging0.89588843
145MP0002693_abnormal_pancreas_physiology0.89280933
146MP0003137_abnormal_impulse_conducting0.89164163
147MP0001216_abnormal_epidermal_layer0.87274547
148MP0005220_abnormal_exocrine_pancreas0.86998642
149MP0002429_abnormal_blood_cell0.86158750
150MP0002722_abnormal_immune_system0.85204034
151MP0004019_abnormal_vitamin_homeostasis0.84148830
152MP0002557_abnormal_social/conspecific_i0.83515002
153MP0005636_abnormal_mineral_homeostasis0.83406649
154MP0009046_muscle_twitch0.82902837
155MP0004381_abnormal_hair_follicle0.82786133
156MP0004510_myositis0.82103782
157MP0010234_abnormal_vibrissa_follicle0.81112042
158MP0001970_abnormal_pain_threshold0.80891085
159MP0001545_abnormal_hematopoietic_system0.80856942
160MP0005397_hematopoietic_system_phenotyp0.80856942
161MP0000026_abnormal_inner_ear0.80713356
162MP0003718_maternal_effect0.80199097
163MP0001756_abnormal_urination0.80163919
164MP0005084_abnormal_gallbladder_morpholo0.80011665
165MP0002163_abnormal_gland_morphology0.79465480
166MP0005394_taste/olfaction_phenotype0.78679267
167MP0005499_abnormal_olfactory_system0.78679267
168MP0001243_abnormal_dermal_layer0.78445360
169MP0001765_abnormal_ion_homeostasis0.78395115
170MP0000470_abnormal_stomach_morphology0.78319467
171MP0002735_abnormal_chemical_nociception0.77565903
172MP0002909_abnormal_adrenal_gland0.77282686

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)4.10897404
2Pancreatic cysts (HP:0001737)3.83406160
3Abnormality of midbrain morphology (HP:0002418)3.40674450
4Molar tooth sign on MRI (HP:0002419)3.40674450
5Pancreatic fibrosis (HP:0100732)3.28437185
6Type II lissencephaly (HP:0007260)3.24203304
7True hermaphroditism (HP:0010459)3.15380935
8Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14943296
9Elevated erythrocyte sedimentation rate (HP:0003565)3.10372420
10Decreased electroretinogram (ERG) amplitude (HP:0000654)3.10166355
11Generalized aminoaciduria (HP:0002909)3.09044966
12Increased CSF lactate (HP:0002490)3.08073499
13Hypoglycemic coma (HP:0001325)3.02398817
14Attenuation of retinal blood vessels (HP:0007843)3.00433674
15Acute necrotizing encephalopathy (HP:0006965)3.00250650
16Abnormality of fatty-acid metabolism (HP:0004359)2.95283193
17Eczematoid dermatitis (HP:0000976)2.92291384
18Abnormal mitochondria in muscle tissue (HP:0008316)2.88345421
19Abolished electroretinogram (ERG) (HP:0000550)2.87997733
20Nephronophthisis (HP:0000090)2.84848153
21Hepatic necrosis (HP:0002605)2.77490893
22Cerebellar dysplasia (HP:0007033)2.76922320
23Abnormality of the renal cortex (HP:0011035)2.76817554
24Acute encephalopathy (HP:0006846)2.75276806
253-Methylglutaconic aciduria (HP:0003535)2.68782761
26Increased muscle lipid content (HP:0009058)2.67828721
27Xanthomatosis (HP:0000991)2.65738346
28Abnormal rod and cone electroretinograms (HP:0008323)2.64922230
29Vacuolated lymphocytes (HP:0001922)2.63907144
30Abnormality of alanine metabolism (HP:0010916)2.61615040
31Hyperalaninemia (HP:0003348)2.61615040
32Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.61615040
33Hypoplasia of the pons (HP:0012110)2.58475581
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.55248012
35Medial flaring of the eyebrow (HP:0010747)2.51514107
36Abnormality of the renal medulla (HP:0100957)2.50849797
37Abnormal drinking behavior (HP:0030082)2.50814593
38Polydipsia (HP:0001959)2.50814593
39Abnormality of dicarboxylic acid metabolism (HP:0010995)2.49571462
40Dicarboxylic aciduria (HP:0003215)2.49571462
41Abnormal hemoglobin (HP:0011902)2.49538464
42Concave nail (HP:0001598)2.48816143
43Abnormality of the pons (HP:0007361)2.47396031
44Progressive macrocephaly (HP:0004481)2.43321902
45Recurrent abscess formation (HP:0002722)2.42481917
46Myoglobinuria (HP:0002913)2.42247136
47Ketosis (HP:0001946)2.36782671
48Decreased central vision (HP:0007663)2.35654843
49Abnormality of cells of the erythroid lineage (HP:0012130)2.35646800
50Nausea (HP:0002018)2.34598011
51Hypertriglyceridemia (HP:0002155)2.32643487
52Dynein arm defect of respiratory motile cilia (HP:0012255)2.32266217
53Absent/shortened dynein arms (HP:0200106)2.32266217
54Tubular atrophy (HP:0000092)2.32107777
55Increased hepatocellular lipid droplets (HP:0006565)2.30615296
56Abnormal number of erythroid precursors (HP:0012131)2.30396833
57IgG deficiency (HP:0004315)2.30262498
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28458796
59Thrombocytosis (HP:0001894)2.28116795
60Hyperglycinuria (HP:0003108)2.25041307
61Cystic liver disease (HP:0006706)2.24056781
62Decreased activity of mitochondrial respiratory chain (HP:0008972)2.23599071
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.23599071
64Hepatocellular necrosis (HP:0001404)2.23277892
65Methylmalonic aciduria (HP:0012120)2.23265774
66Ketoacidosis (HP:0001993)2.23186853
67Ventricular tachycardia (HP:0004756)2.22026010
68Recurrent bacterial skin infections (HP:0005406)2.21251584
69Rhabdomyolysis (HP:0003201)2.20917597
70Hyperammonemia (HP:0001987)2.20468152
71Multiple enchondromatosis (HP:0005701)2.20044564
72Increased serum lactate (HP:0002151)2.19772361
73Abnormality of the nasal mucosa (HP:0000433)2.16511938
74Renal Fanconi syndrome (HP:0001994)2.16506367
75Abnormal respiratory motile cilium morphology (HP:0005938)2.16241296
76Abnormal respiratory epithelium morphology (HP:0012253)2.16241296
77Autoimmune thrombocytopenia (HP:0001973)2.16188313
78Lactic acidosis (HP:0003128)2.15846218
79Myocardial infarction (HP:0001658)2.15554284
80Increased serum ferritin (HP:0003281)2.14973782
81Sclerocornea (HP:0000647)2.14684496
82Optic disc pallor (HP:0000543)2.14562062
83Mesangial abnormality (HP:0001966)2.13398121
84Acanthosis nigricans (HP:0000956)2.13110074
85Recurrent gram-negative bacterial infections (HP:0005420)2.12419811
86Retinal dysplasia (HP:0007973)2.10809407
87Microcytic anemia (HP:0001935)2.10216823
88Aplasia/hypoplasia of the uterus (HP:0008684)2.09556233
89Late onset (HP:0003584)2.08794862
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.08428122
91Urticaria (HP:0001025)2.07716691
92Hyperlipoproteinemia (HP:0010980)2.07627332
93Nasal polyposis (HP:0100582)2.07062881
94Chronic otitis media (HP:0000389)2.05378015
95Recurrent bronchitis (HP:0002837)2.04649395
96Severe muscular hypotonia (HP:0006829)2.03673402
97Cerebral palsy (HP:0100021)2.03526648
98Reticulocytopenia (HP:0001896)2.03141372
99Abnormality of macrophages (HP:0004311)2.00314454
100Increased intramyocellular lipid droplets (HP:0012240)2.00044578
101Polyuria (HP:0000103)1.99881697
102Aplasia/Hypoplasia of the sacrum (HP:0008517)1.99256816
103Conjunctival hamartoma (HP:0100780)1.99080548
104Congenital hepatic fibrosis (HP:0002612)1.98909449
105Pendular nystagmus (HP:0012043)1.98132890
106Aplasia/Hypoplasia of the spleen (HP:0010451)1.97402568
107Lipoatrophy (HP:0100578)1.97369889
108Decreased circulating renin level (HP:0003351)1.96856539
109Absent thumb (HP:0009777)1.95317188
110Myositis (HP:0100614)1.94960740
111Abnormality of T cell physiology (HP:0011840)1.93877652
112Hyperglycinemia (HP:0002154)1.93859984
113Recurrent skin infections (HP:0001581)1.93626096
114Abnormality of monocarboxylic acid metabolism (HP:0010996)1.93276734
115Vertebral compression fractures (HP:0002953)1.91683884
116Asplenia (HP:0001746)1.91173745
117Renal cortical cysts (HP:0000803)1.91060405
118Aplasia/Hypoplasia of the patella (HP:0006498)1.90461939
119Right ventricular cardiomyopathy (HP:0011663)1.89888610
120Purpura (HP:0000979)1.89420406
121Abnormality of serine family amino acid metabolism (HP:0010894)1.89410417
122Abnormality of glycine metabolism (HP:0010895)1.89410417
123Lethargy (HP:0001254)1.89269552
124Abnormal biliary tract physiology (HP:0012439)1.89221430
125Bile duct proliferation (HP:0001408)1.89221430
126Colitis (HP:0002583)1.89158075
127Abnormality of iron homeostasis (HP:0011031)1.88953164
128Male pseudohermaphroditism (HP:0000037)1.88688386
129Patellar aplasia (HP:0006443)1.88433373
130Pancreatitis (HP:0001733)1.88421776
131Inflammation of the large intestine (HP:0002037)1.87622455
132Congenital, generalized hypertrichosis (HP:0004540)1.86945637
133Chronic hepatic failure (HP:0100626)1.86152192
134Cerebral edema (HP:0002181)1.86023565
135Gastrointestinal inflammation (HP:0004386)1.85407322
136Progressive microcephaly (HP:0000253)1.85233629
137Hypoalphalipoproteinemia (HP:0003233)1.85009559
138Agammaglobulinemia (HP:0004432)1.84831755
139Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.83341671
140Intrahepatic cholestasis (HP:0001406)1.83310230
141Cellulitis (HP:0100658)1.82712882
142Pustule (HP:0200039)1.82124170
143Large for gestational age (HP:0001520)1.81785915
144Skin rash (HP:0000988)1.81694095
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80048112
146Recurrent fungal infections (HP:0002841)1.79256158
147Reduced subcutaneous adipose tissue (HP:0003758)1.78813299
148Spontaneous hematomas (HP:0007420)1.78518601
149Amelogenesis imperfecta (HP:0000705)1.78132089
150Abnormality of transition element cation homeostasis (HP:0011030)1.77587356
151Methylmalonic acidemia (HP:0002912)1.77556202
152Type I transferrin isoform profile (HP:0003642)1.77074196
153Abnormal cartilage morphology (HP:0002763)1.76633240
154Stomatitis (HP:0010280)1.76491729
155Deep venous thrombosis (HP:0002625)1.76142308
156Abnormal respiratory motile cilium physiology (HP:0012261)1.76036173
157Glycosuria (HP:0003076)1.75144539
158Abnormality of urine glucose concentration (HP:0011016)1.75144539
159Interstitial pulmonary disease (HP:0006530)1.75124188
160Hyperbilirubinemia (HP:0002904)1.74777553
161Lipid accumulation in hepatocytes (HP:0006561)1.74631336
162Clumsiness (HP:0002312)1.74233527
163Abnormal ciliary motility (HP:0012262)1.74205063
164Prostate neoplasm (HP:0100787)1.74131692
165Delayed CNS myelination (HP:0002188)1.74115681
166Type 2 muscle fiber atrophy (HP:0003554)1.74077653
167Abnormality of T cells (HP:0002843)1.73740210
168Dilated cardiomyopathy (HP:0001644)1.71935449
169Macrocytic anemia (HP:0001972)1.71168186
170Insulin resistance (HP:0000855)1.71119176
171Abnormality of complement system (HP:0005339)1.69541440
172Prolonged partial thromboplastin time (HP:0003645)1.68802480
173Asymmetric septal hypertrophy (HP:0001670)1.68528433
174IgM deficiency (HP:0002850)1.67217702
175Paralysis (HP:0003470)1.66934303
176Mitochondrial inheritance (HP:0001427)1.66612044
177Verrucae (HP:0200043)1.65930618
178Papilloma (HP:0012740)1.65930618
179Petechiae (HP:0000967)1.64986151
180Exertional dyspnea (HP:0002875)1.64590645
181Hypergammaglobulinemia (HP:0010702)1.64538549
182Abnormality of T cell number (HP:0011839)1.63599015
183Systemic lupus erythematosus (HP:0002725)1.63560016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.97491787
2BCKDK3.57971675
3NME23.55822012
4ERN13.20617433
5ADRBK23.06146134
6TRIB33.02448664
7ZAK2.93620726
8GRK12.81964304
9VRK22.66516314
10BMPR1B2.58222920
11MAP4K12.55261910
12TBK12.33195183
13MUSK2.30796068
14NUAK12.30444054
15WNK42.27370524
16MAP4K22.25960684
17IRAK32.13171548
18KDR2.04892001
19PIM22.01959689
20BLK1.97510571
21IRAK41.92989318
22IKBKE1.92422051
23MAP3K141.87019535
24INSRR1.82657008
25TYK21.80230653
26FGFR41.79207107
27PINK11.69951722
28JAK31.69759715
29MAPK131.64711986
30ACVR1B1.63784549
31LRRK21.56661195
32ZAP701.50116281
33TLK11.47968331
34FLT31.46391263
35WNK31.43728644
36RPS6KA41.41904724
37PKN21.41770899
38MYLK1.41464238
39IKBKB1.39341746
40MAPKAPK31.39245248
41MAP3K31.39145710
42TNK21.35733395
43NEK91.35237215
44TTN1.31814534
45MAP2K21.29506996
46PIK3CG1.27963181
47MST41.27740078
48TESK21.26795523
49NLK1.25598566
50TGFBR21.25353002
51MAP2K31.22732613
52STK101.20820419
53TESK11.20820046
54ADRBK11.17132834
55SIK11.16816922
56VRK11.14871718
57KIT1.13744215
58MAP3K111.11839511
59STK161.11330251
60STK391.11287251
61ILK1.10037879
62EPHB11.07323850
63MAP2K61.06550669
64TEC1.03427904
65BTK1.02360407
66TXK1.01293591
67CSK0.97580037
68PRKCI0.95852684
69PHKG20.93109270
70PHKG10.93109270
71PTK2B0.93076910
72DYRK20.92780990
73MAPK110.88699998
74PIM10.88669589
75MAP3K100.88150953
76DAPK20.87690916
77LIMK10.87262087
78PRKCQ0.86631013
79JAK10.83845220
80IRAK10.82307529
81ABL20.77021225
82EIF2AK10.76116262
83MAP2K70.74592210
84DYRK1B0.74044020
85PBK0.74024232
86CHUK0.73794013
87OXSR10.72646853
88PIK3CA0.72452608
89DAPK30.70139143
90STK40.69258631
91TIE10.68513326
92EPHA30.68466996
93CSNK1G30.68298102
94NME10.67358560
95TRPM70.66251251
96PRKD20.66169811
97TGFBR10.65797551
98JAK20.65223717
99MST1R0.64081370
100SYK0.63871622
101ITK0.63649200
102PTK60.63594091
103CDK190.62201526
104MAPK150.62191050
105PRKCE0.61823804
106TAOK30.61331469
107LCK0.61241567
108IRAK20.60887770
109OBSCN0.60348676
110MAPKAPK20.60062893
111GRK70.59056786
112PRKG20.58998303
113RPS6KA50.58671707
114CSNK1G10.57854246
115MAP3K80.57292613
116MARK30.54846444
117GRK50.54543060
118EPHB20.54441658
119CSNK1G20.54038014
120HIPK20.53595584
121CDK90.53291878
122GRK60.53201687
123CCNB10.52733321
124CSF1R0.52031076
125LYN0.50954513
126PRKCG0.49358125
127CDK80.48808945
128DYRK30.48076298
129ARAF0.47902052
130PRKD10.47407961
131CSNK1A10.46212067
132PRKAA20.45738489
133FGFR30.45257473
134EEF2K0.45165822
135RPS6KB20.44227660
136PRKACA0.43312384
137PKN10.43004672
138STK110.42832092
139CSNK1A1L0.42746027
140EPHA20.42264543
141RIPK10.40213568
142MAP3K40.39482168
143PAK30.39452223
144STK240.39015518
145PRKCA0.38205191
146CAMK10.37487849
147RPS6KA60.37197369
148CAMKK20.36700569
149HCK0.35532971
150PRKCZ0.35513450
151CDK60.32791791
152DMPK0.30202040
153ABL10.29593826
154PRKD30.29286600
155TAOK20.29140820

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030102.83918415
2Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.83474529
3RNA polymerase_Homo sapiens_hsa030202.36409002
4Protein export_Homo sapiens_hsa030602.31849339
5Fatty acid degradation_Homo sapiens_hsa000712.28056593
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.27395518
7Phototransduction_Homo sapiens_hsa047442.18616173
8Folate biosynthesis_Homo sapiens_hsa007901.97986505
9Propanoate metabolism_Homo sapiens_hsa006401.82279763
10Caffeine metabolism_Homo sapiens_hsa002321.80991305
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.80718797
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.79039266
13Huntingtons disease_Homo sapiens_hsa050161.78482305
14Sulfur relay system_Homo sapiens_hsa041221.75554741
15Nitrogen metabolism_Homo sapiens_hsa009101.72294087
16Peroxisome_Homo sapiens_hsa041461.66672886
17Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.66027692
18Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.62835206
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.62071494
20PPAR signaling pathway_Homo sapiens_hsa033201.61551133
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.59231103
22Primary immunodeficiency_Homo sapiens_hsa053401.55347553
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.52907030
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.51709175
25Tryptophan metabolism_Homo sapiens_hsa003801.50976216
26Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.50332957
27Asthma_Homo sapiens_hsa053101.48041571
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46606085
29Staphylococcus aureus infection_Homo sapiens_hsa051501.46334375
30Fatty acid metabolism_Homo sapiens_hsa012121.41866823
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41471120
32Homologous recombination_Homo sapiens_hsa034401.40952479
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40846271
34Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40115614
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37406463
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35811190
37Leishmaniasis_Homo sapiens_hsa051401.35223164
38beta-Alanine metabolism_Homo sapiens_hsa004101.31778937
39Cardiac muscle contraction_Homo sapiens_hsa042601.31419322
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27677176
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.24557212
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.22765075
43Chemical carcinogenesis_Homo sapiens_hsa052041.22353166
44Fatty acid elongation_Homo sapiens_hsa000621.22031299
45Histidine metabolism_Homo sapiens_hsa003401.21360257
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21186822
47Type I diabetes mellitus_Homo sapiens_hsa049401.20825831
48Ether lipid metabolism_Homo sapiens_hsa005651.18606879
492-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12869895
50Other glycan degradation_Homo sapiens_hsa005111.12860524
51Maturity onset diabetes of the young_Homo sapiens_hsa049501.12686712
52Fanconi anemia pathway_Homo sapiens_hsa034601.12165871
53Parkinsons disease_Homo sapiens_hsa050121.11196315
54Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.08292767
55Phenylalanine metabolism_Homo sapiens_hsa003601.08199795
56Oxidative phosphorylation_Homo sapiens_hsa001901.07653982
57Pyrimidine metabolism_Homo sapiens_hsa002401.06626474
58NF-kappa B signaling pathway_Homo sapiens_hsa040641.06603230
59Graft-versus-host disease_Homo sapiens_hsa053321.06589878
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06577613
61Carbon metabolism_Homo sapiens_hsa012001.06503615
62Legionellosis_Homo sapiens_hsa051341.06393738
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.04704247
64Fat digestion and absorption_Homo sapiens_hsa049751.04403003
65Sulfur metabolism_Homo sapiens_hsa009201.01610301
66Complement and coagulation cascades_Homo sapiens_hsa046101.01030004
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.00416901
68Malaria_Homo sapiens_hsa051440.99638444
69Glutathione metabolism_Homo sapiens_hsa004800.99123276
70Measles_Homo sapiens_hsa051620.98228843
71Pentose phosphate pathway_Homo sapiens_hsa000300.97943288
72Antigen processing and presentation_Homo sapiens_hsa046120.96821946
73Regulation of autophagy_Homo sapiens_hsa041400.94638415
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.93861274
75Basal transcription factors_Homo sapiens_hsa030220.92531353
76Pyruvate metabolism_Homo sapiens_hsa006200.92123822
77Allograft rejection_Homo sapiens_hsa053300.88008845
78Hematopoietic cell lineage_Homo sapiens_hsa046400.87439533
79Proteasome_Homo sapiens_hsa030500.84593971
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84124785
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83875026
82Collecting duct acid secretion_Homo sapiens_hsa049660.81517212
83Starch and sucrose metabolism_Homo sapiens_hsa005000.81362170
84SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81289906
85Purine metabolism_Homo sapiens_hsa002300.81253195
86Pertussis_Homo sapiens_hsa051330.76939859
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76028508
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75765762
89Base excision repair_Homo sapiens_hsa034100.75494302
90Rheumatoid arthritis_Homo sapiens_hsa053230.74680489
91Tyrosine metabolism_Homo sapiens_hsa003500.73959949
92RNA degradation_Homo sapiens_hsa030180.73316992
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.72389702
94Viral myocarditis_Homo sapiens_hsa054160.72221153
95Vitamin digestion and absorption_Homo sapiens_hsa049770.70045421
96Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70022381
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.68816890
98Glycosaminoglycan degradation_Homo sapiens_hsa005310.68122318
99Arginine biosynthesis_Homo sapiens_hsa002200.67245673
100Arachidonic acid metabolism_Homo sapiens_hsa005900.66401715
101Selenocompound metabolism_Homo sapiens_hsa004500.65782082
102ABC transporters_Homo sapiens_hsa020100.64713509
103Acute myeloid leukemia_Homo sapiens_hsa052210.64224186
104Olfactory transduction_Homo sapiens_hsa047400.64057688
105B cell receptor signaling pathway_Homo sapiens_hsa046620.63871855
106Retinol metabolism_Homo sapiens_hsa008300.63029248
107Toxoplasmosis_Homo sapiens_hsa051450.62703285
108Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.62666289
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.61317007
110Alzheimers disease_Homo sapiens_hsa050100.60795570
111Apoptosis_Homo sapiens_hsa042100.60539329
112Herpes simplex infection_Homo sapiens_hsa051680.60493827
113Osteoclast differentiation_Homo sapiens_hsa043800.60435722
114Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59706972
115Glycerolipid metabolism_Homo sapiens_hsa005610.58402535
116Taste transduction_Homo sapiens_hsa047420.57818171
117One carbon pool by folate_Homo sapiens_hsa006700.57571858
118Lysosome_Homo sapiens_hsa041420.57265762
119Arginine and proline metabolism_Homo sapiens_hsa003300.57076789
120Butanoate metabolism_Homo sapiens_hsa006500.55333776
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52451222
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51515303
123Ovarian steroidogenesis_Homo sapiens_hsa049130.51093122
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.50698733
125Shigellosis_Homo sapiens_hsa051310.49864887
126Influenza A_Homo sapiens_hsa051640.49690088
127Linoleic acid metabolism_Homo sapiens_hsa005910.49567067
128Nicotine addiction_Homo sapiens_hsa050330.47779326
129Insulin resistance_Homo sapiens_hsa049310.47420192
130Metabolic pathways_Homo sapiens_hsa011000.46456206
131Galactose metabolism_Homo sapiens_hsa000520.46049122
132Biosynthesis of amino acids_Homo sapiens_hsa012300.45182333
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.43261815
134Autoimmune thyroid disease_Homo sapiens_hsa053200.42990295
135Glycerophospholipid metabolism_Homo sapiens_hsa005640.40938375
136Cysteine and methionine metabolism_Homo sapiens_hsa002700.35846218
137Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34179905
138Morphine addiction_Homo sapiens_hsa050320.31609322

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