TMEM136

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of rhodopsin mediated signaling pathway (GO:0022400)6.28572074
2rhodopsin mediated signaling pathway (GO:0016056)6.09226681
3nonmotile primary cilium assembly (GO:0035058)5.76381220
4neuron cell-cell adhesion (GO:0007158)4.94851395
5response to pheromone (GO:0019236)4.66060617
6protein localization to synapse (GO:0035418)4.61191218
7retinal cone cell development (GO:0046549)4.42507370
8positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.37799508
9vocalization behavior (GO:0071625)4.29810193
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.27899671
11photoreceptor cell maintenance (GO:0045494)4.13527666
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.10125018
13glutamate receptor signaling pathway (GO:0007215)3.93633880
14photoreceptor cell development (GO:0042461)3.91252662
15eye photoreceptor cell development (GO:0042462)3.85187411
16negative regulation of synaptic transmission, GABAergic (GO:0032229)3.77897348
17detection of light stimulus involved in sensory perception (GO:0050962)3.75947076
18detection of light stimulus involved in visual perception (GO:0050908)3.75947076
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.70653290
20presynaptic membrane assembly (GO:0097105)3.70177738
21fibroblast migration (GO:0010761)3.68330898
22lateral sprouting from an epithelium (GO:0060601)3.60775375
23regulation of glutamate receptor signaling pathway (GO:1900449)3.60542658
24eye photoreceptor cell differentiation (GO:0001754)3.59145873
25photoreceptor cell differentiation (GO:0046530)3.59145873
26synaptic transmission, glutamatergic (GO:0035249)3.57833673
27neuron recognition (GO:0008038)3.50642783
28regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.50205424
29substrate-independent telencephalic tangential migration (GO:0021826)3.47313652
30substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.47313652
31postsynaptic membrane organization (GO:0001941)3.45307766
32locomotory exploration behavior (GO:0035641)3.44201750
33behavioral response to nicotine (GO:0035095)3.40513222
34cerebral cortex radially oriented cell migration (GO:0021799)3.40471881
35neuron-neuron synaptic transmission (GO:0007270)3.39993788
36transmission of nerve impulse (GO:0019226)3.34282702
37retinal rod cell development (GO:0046548)3.31722448
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.30989110
39presynaptic membrane organization (GO:0097090)3.28107405
40phototransduction (GO:0007602)3.27501416
41positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.25923319
42detection of visible light (GO:0009584)3.23087760
43phototransduction, visible light (GO:0007603)3.22860389
44detection of light stimulus (GO:0009583)3.18577672
45glycosphingolipid biosynthetic process (GO:0006688)3.18307729
46metanephric nephron tubule development (GO:0072234)3.17243242
47metanephric tubule development (GO:0072170)3.17243242
48G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.16534113
49central nervous system myelination (GO:0022010)3.13839527
50axon ensheathment in central nervous system (GO:0032291)3.13839527
51synaptic vesicle exocytosis (GO:0016079)3.06677369
52dendritic spine morphogenesis (GO:0060997)3.03082724
53exploration behavior (GO:0035640)2.98284951
54spinal cord motor neuron differentiation (GO:0021522)2.96075345
55L-amino acid import (GO:0043092)2.96023956
56righting reflex (GO:0060013)2.95421523
57platelet dense granule organization (GO:0060155)2.95293240
58gamma-aminobutyric acid transport (GO:0015812)2.94381100
59cell differentiation involved in metanephros development (GO:0072202)2.93097247
60pyrimidine nucleobase catabolic process (GO:0006208)2.89943252
61spinal cord association neuron differentiation (GO:0021527)2.89668618
62amino acid import (GO:0043090)2.89456084
63metanephric nephron epithelium development (GO:0072243)2.88811796
64kidney morphogenesis (GO:0060993)2.87066475
65visual perception (GO:0007601)2.86528124
66regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85606002
67inner ear receptor stereocilium organization (GO:0060122)2.84862223
68positive regulation of synapse assembly (GO:0051965)2.84172063
69sensory perception of light stimulus (GO:0050953)2.83715502
70neuronal action potential propagation (GO:0019227)2.82886081
71negative regulation of cytosolic calcium ion concentration (GO:0051481)2.80636566
72neurofilament cytoskeleton organization (GO:0060052)2.80385984
73retina layer formation (GO:0010842)2.79427690
74startle response (GO:0001964)2.79308411
75Leydig cell differentiation (GO:0033327)2.79165044
76positive regulation of membrane potential (GO:0045838)2.78953886
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77616270
78cell differentiation in spinal cord (GO:0021515)2.77351873
79regulation of postsynaptic membrane potential (GO:0060078)2.77180934
80neurotransmitter-gated ion channel clustering (GO:0072578)2.76720603
81synaptic vesicle maturation (GO:0016188)2.76711369
82negative regulation of heart rate (GO:0010459)2.76204379
83regulation of voltage-gated calcium channel activity (GO:1901385)2.75838217
84chemosensory behavior (GO:0007635)2.75830472
85glutamate secretion (GO:0014047)2.75290156
86histone mRNA catabolic process (GO:0071044)2.74944243
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.74171207
88axonal fasciculation (GO:0007413)2.73134234
89retinal ganglion cell axon guidance (GO:0031290)2.72376346
90positive regulation of action potential (GO:0045760)2.72090495
91cardiac myofibril assembly (GO:0055003)2.71748307
92nucleobase catabolic process (GO:0046113)2.71582567
93metanephric epithelium development (GO:0072207)2.71549588
94protein complex biogenesis (GO:0070271)2.71008549
95hypothalamus development (GO:0021854)2.70921185
96long-term synaptic potentiation (GO:0060291)2.70135312
97cornea development in camera-type eye (GO:0061303)2.70058177
98nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.68742822
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.66921018
100negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.66775085
101negative regulation of response to food (GO:0032096)2.66382242
102negative regulation of appetite (GO:0032099)2.66382242
103short-term memory (GO:0007614)2.66063548
104regulation of synaptic vesicle exocytosis (GO:2000300)2.65460622
105regulation of action potential (GO:0098900)2.63545697
106membrane hyperpolarization (GO:0060081)2.63458673
107multicellular organismal signaling (GO:0035637)2.61834329
108regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61446125
109neuron remodeling (GO:0016322)2.61369493
110sialylation (GO:0097503)2.60913810
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.60515550
112transcytosis (GO:0045056)2.60464625
113mitochondrial respiratory chain complex I assembly (GO:0032981)2.60111633
114NADH dehydrogenase complex assembly (GO:0010257)2.60111633
115mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.60111633
116nephron epithelium morphogenesis (GO:0072088)2.59496628
117nephron tubule morphogenesis (GO:0072078)2.59496628
118DNA double-strand break processing (GO:0000729)2.58997331
119mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.58878115
120protein localization to cilium (GO:0061512)2.58620865
121somite development (GO:0061053)2.58610296
122long-term memory (GO:0007616)2.57419382
123somite rostral/caudal axis specification (GO:0032525)2.56591919
124cochlea development (GO:0090102)2.55933679
125regulation of meiosis I (GO:0060631)2.55898670
126epithelial cilium movement (GO:0003351)2.55029789
127behavioral response to ethanol (GO:0048149)2.52848161
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.51301166
129mitochondrial respiratory chain complex assembly (GO:0033108)2.51136709
130acrosome assembly (GO:0001675)2.51022008
131cullin deneddylation (GO:0010388)2.48137753
132positive regulation of mitochondrial fission (GO:0090141)2.47364154
133positive regulation of digestive system process (GO:0060456)2.47351787
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.44379344
135water-soluble vitamin biosynthetic process (GO:0042364)2.43445489
136C4-dicarboxylate transport (GO:0015740)2.41751910
137mannosylation (GO:0097502)2.38932349
138mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.38560264
139auditory behavior (GO:0031223)2.36909065
140cilium morphogenesis (GO:0060271)2.36745812
141respiratory chain complex IV assembly (GO:0008535)2.34936994
142intraciliary transport (GO:0042073)2.33120190
143DNA damage response, detection of DNA damage (GO:0042769)2.31748039
144negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.31649645
145renal tubule morphogenesis (GO:0061333)2.30131624
146calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.29684307
147regulation of neurotransmitter uptake (GO:0051580)2.28830794
148cilium organization (GO:0044782)2.27906436
149regulation of non-canonical Wnt signaling pathway (GO:2000050)2.27443590
150protein polyglutamylation (GO:0018095)2.26142313
151chaperone-mediated protein transport (GO:0072321)2.23736816
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.23277138
153labyrinthine layer development (GO:0060711)2.23093200
154response to nitrosative stress (GO:0051409)2.22958165
155protein deneddylation (GO:0000338)2.22698687
156cilium assembly (GO:0042384)2.20044084
157L-fucose catabolic process (GO:0042355)2.19990119
158fucose catabolic process (GO:0019317)2.19990119
159L-fucose metabolic process (GO:0042354)2.19990119
160ATP synthesis coupled proton transport (GO:0015986)2.19361863
161energy coupled proton transport, down electrochemical gradient (GO:0015985)2.19361863
162regulation of cilium movement (GO:0003352)2.17904048
163L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.16419314
164cellular ketone body metabolic process (GO:0046950)2.15686115
165glycerophospholipid catabolic process (GO:0046475)2.15251633
166preassembly of GPI anchor in ER membrane (GO:0016254)2.14887670
167protein neddylation (GO:0045116)2.12528166
168magnesium ion transport (GO:0015693)2.11736884
169smoothened signaling pathway (GO:0007224)2.11568286
170limb bud formation (GO:0060174)2.11017427
171cilium movement (GO:0003341)2.09674312
172positive regulation of meiosis (GO:0045836)2.09068794
173seminiferous tubule development (GO:0072520)2.09017487
174protein-cofactor linkage (GO:0018065)2.08132494
175otic vesicle formation (GO:0030916)2.07533892
176RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.04746518
177tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.04746518

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.48466507
2EZH2_22144423_ChIP-Seq_EOC_Human4.11787025
3ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.08972019
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.94265061
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.92869585
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.88636177
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77214141
8SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.75107007
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.72800690
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.68246791
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.68246791
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55657394
13IGF1R_20145208_ChIP-Seq_DFB_Human2.55482716
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.55446505
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.42036864
16TAF15_26573619_Chip-Seq_HEK293_Human2.36035711
17AR_21572438_ChIP-Seq_LNCaP_Human2.27007004
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.21418811
19MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16434833
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15904312
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.12699899
22RNF2_27304074_Chip-Seq_ESCs_Mouse2.12467517
23RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.08312974
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07966650
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07179193
26PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.04587287
27RBPJ_22232070_ChIP-Seq_NCS_Mouse2.01893502
28DROSHA_22980978_ChIP-Seq_HELA_Human1.92254882
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91011992
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.88791382
31HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.86921945
32REST_21632747_ChIP-Seq_MESCs_Mouse1.83680352
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.81496977
34PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78726093
35GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78019521
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.74946605
37E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73132903
38MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71047191
39BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68602269
40HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.64427220
41KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.63277746
42SMAD4_21799915_ChIP-Seq_A2780_Human1.63078607
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.62959475
44P300_19829295_ChIP-Seq_ESCs_Human1.62646508
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60383817
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.60033529
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.59721698
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.58079066
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54981576
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.52007640
51GABP_17652178_ChIP-ChIP_JURKAT_Human1.51627559
52TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.46655476
53MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.44753618
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43856141
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.42471764
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.42327718
57CBP_20019798_ChIP-Seq_JUKART_Human1.42327718
58RNF2_27304074_Chip-Seq_NSC_Mouse1.41644447
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.41139157
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.40801548
61MYC_18940864_ChIP-ChIP_HL60_Human1.36645952
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.34824881
63SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33676596
64CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30231175
65OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28944053
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.28854285
67CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28431820
68IRF1_19129219_ChIP-ChIP_H3396_Human1.27453401
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.26895584
70EST1_17652178_ChIP-ChIP_JURKAT_Human1.26809330
71FUS_26573619_Chip-Seq_HEK293_Human1.25817016
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.25512020
73ZNF274_21170338_ChIP-Seq_K562_Hela1.23425134
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.22351210
75TCF4_22108803_ChIP-Seq_LS180_Human1.21983921
76TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20684292
77FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20500262
78STAT3_23295773_ChIP-Seq_U87_Human1.19569647
79KLF5_20875108_ChIP-Seq_MESCs_Mouse1.18446482
80ELK1_19687146_ChIP-ChIP_HELA_Human1.18235441
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.18156825
82TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.16598862
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16437876
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.16072821
85RARB_27405468_Chip-Seq_BRAIN_Mouse1.15706702
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.15237761
87* TP53_22573176_ChIP-Seq_HFKS_Human1.15160376
88ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14329026
89JUN_21703547_ChIP-Seq_K562_Human1.14029284
90VDR_22108803_ChIP-Seq_LS180_Human1.13995505
91NANOG_19829295_ChIP-Seq_ESCs_Human1.13532802
92SOX2_19829295_ChIP-Seq_ESCs_Human1.13532802
93NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13473799
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11799721
95ER_23166858_ChIP-Seq_MCF-7_Human1.10576640
96SOX2_21211035_ChIP-Seq_LN229_Gbm1.09921637
97RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09440955
98* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07712766
99TCF4_23295773_ChIP-Seq_U87_Human1.06973909
100* RUNX2_22187159_ChIP-Seq_PCA_Human1.06845844
101TP53_20018659_ChIP-ChIP_R1E_Mouse1.06261452
102PRDM14_20953172_ChIP-Seq_ESCs_Human1.05756718
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.04510904
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.04441703
105AR_25329375_ChIP-Seq_VCAP_Human1.03835364
106AHR_22903824_ChIP-Seq_MCF-7_Human1.03359077
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03178668
108TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02352400
109E2F1_18555785_Chip-Seq_ESCs_Mouse1.02135902
110MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02124249
111NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01929980
112SMAD_19615063_ChIP-ChIP_OVARY_Human1.01627676
113AR_19668381_ChIP-Seq_PC3_Human1.00242295
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.00011777
115YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99802711
116* FOXA1_25329375_ChIP-Seq_VCAP_Human0.99796510
117* FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99796510
118P53_22387025_ChIP-Seq_ESCs_Mouse0.98442398
119EZH2_27294783_Chip-Seq_NPCs_Mouse0.98147224
120TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.98008441
121SOX9_26525672_Chip-Seq_HEART_Mouse0.97971804
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.97796535
123BCAT_22108803_ChIP-Seq_LS180_Human0.97539134
124SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.96955815
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96916579
126POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96829607
127TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96829607
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96524209
129TAL1_26923725_Chip-Seq_HPCs_Mouse0.96409487
130EP300_21415370_ChIP-Seq_HL-1_Mouse0.96301905
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96152076
132CMYC_18555785_Chip-Seq_ESCs_Mouse0.95445300
133NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94172005
134EWS_26573619_Chip-Seq_HEK293_Human0.93399779
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.92940599
136POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92476670
137SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92060549
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91715063
139FLI1_27457419_Chip-Seq_LIVER_Mouse0.91598568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.92882163
2MP0005551_abnormal_eye_electrophysiolog4.11529574
3MP0004859_abnormal_synaptic_plasticity3.71057210
4MP0003941_abnormal_skin_development3.43155523
5MP0005423_abnormal_somatic_nervous3.14270211
6MP0002736_abnormal_nociception_after2.95654063
7MP0006072_abnormal_retinal_apoptosis2.93727277
8MP0005253_abnormal_eye_physiology2.85009019
9MP0001968_abnormal_touch/_nociception2.82810863
10MP0003635_abnormal_synaptic_transmissio2.67641845
11MP0005646_abnormal_pituitary_gland2.64504738
12MP0003011_delayed_dark_adaptation2.63631885
13MP0005645_abnormal_hypothalamus_physiol2.48471261
14MP0001486_abnormal_startle_reflex2.37984175
15MP0003787_abnormal_imprinting2.22264844
16MP0001188_hyperpigmentation2.16570531
17MP0009745_abnormal_behavioral_response2.16184277
18MP0008877_abnormal_DNA_methylation2.13056703
19MP0000566_synostosis2.11331053
20MP0002063_abnormal_learning/memory/cond2.07739655
21MP0004270_analgesia2.02433043
22MP0002064_seizures2.02270153
23MP0000778_abnormal_nervous_system1.98595873
24MP0002572_abnormal_emotion/affect_behav1.95924928
25MP0002272_abnormal_nervous_system1.89084094
26MP0003121_genomic_imprinting1.88580402
27MP0002938_white_spotting1.86998269
28MP0002067_abnormal_sensory_capabilities1.82444046
29MP0002184_abnormal_innervation1.79465992
30MP0002102_abnormal_ear_morphology1.78897310
31MP0003890_abnormal_embryonic-extraembry1.77946901
32MP0004885_abnormal_endolymph1.75352352
33MP0004142_abnormal_muscle_tone1.73158413
34MP0006292_abnormal_olfactory_placode1.72557642
35MP0005409_darkened_coat_color1.64393571
36MP0002638_abnormal_pupillary_reflex1.63999466
37MP0005195_abnormal_posterior_eye1.63455358
38MP0009046_muscle_twitch1.62541071
39MP0005084_abnormal_gallbladder_morpholo1.62198173
40MP0001984_abnormal_olfaction1.60168848
41MP0002557_abnormal_social/conspecific_i1.59377130
42MP0002752_abnormal_somatic_nervous1.56428450
43MP0002837_dystrophic_cardiac_calcinosis1.53945559
44MP0001293_anophthalmia1.53640408
45MP0002882_abnormal_neuron_morphology1.53528051
46MP0010386_abnormal_urinary_bladder1.51984513
47MP0004133_heterotaxia1.48181297
48MP0002234_abnormal_pharynx_morphology1.47564094
49MP0003385_abnormal_body_wall1.42208762
50MP0003938_abnormal_ear_development1.42055711
51MP0005187_abnormal_penis_morphology1.39442109
52MP0001440_abnormal_grooming_behavior1.38609421
53MP0005257_abnormal_intraocular_pressure1.38514675
54MP0002734_abnormal_mechanical_nocicepti1.38064513
55MP0002735_abnormal_chemical_nociception1.36710837
56MP0005391_vision/eye_phenotype1.35985456
57MP0000372_irregular_coat_pigmentation1.34557461
58MP0002229_neurodegeneration1.30279763
59MP0000955_abnormal_spinal_cord1.28017199
60MP0006276_abnormal_autonomic_nervous1.27483299
61MP0000631_abnormal_neuroendocrine_gland1.26164240
62MP0000516_abnormal_urinary_system1.25565367
63MP0005367_renal/urinary_system_phenotyp1.25565367
64MP0000026_abnormal_inner_ear1.25454252
65MP0000049_abnormal_middle_ear1.24438502
66MP0001501_abnormal_sleep_pattern1.23658216
67MP0000569_abnormal_digit_pigmentation1.23490949
68MP0003937_abnormal_limbs/digits/tail_de1.22702411
69MP0004742_abnormal_vestibular_system1.22069805
70MP0009250_abnormal_appendicular_skeleto1.19864560
71MP0008995_early_reproductive_senescence1.19350553
72MP0002090_abnormal_vision1.18733442
73MP0003634_abnormal_glial_cell1.18555803
74MP0003567_abnormal_fetal_cardiomyocyte1.15575319
75MP0003283_abnormal_digestive_organ1.14948242
76MP0004134_abnormal_chest_morphology1.14492542
77MP0003119_abnormal_digestive_system1.13484695
78MP0002249_abnormal_larynx_morphology1.13319660
79MP0001963_abnormal_hearing_physiology1.11862262
80MP0004147_increased_porphyrin_level1.11636222
81MP0001502_abnormal_circadian_rhythm1.10690886
82MP0004924_abnormal_behavior1.10500126
83MP0005386_behavior/neurological_phenoty1.10500126
84MP0002066_abnormal_motor_capabilities/c1.09450798
85MP0002160_abnormal_reproductive_system1.05398235
86MP0001970_abnormal_pain_threshold1.04567681
87MP0003950_abnormal_plasma_membrane1.01627160
88MP0000534_abnormal_ureter_morphology1.01184102
89MP0002733_abnormal_thermal_nociception1.00637481
90MP0001958_emphysema1.00397124
91MP0005171_absent_coat_pigmentation0.99991212
92MP0004215_abnormal_myocardial_fiber0.98980076
93MP0003755_abnormal_palate_morphology0.97409071
94MP0009780_abnormal_chondrocyte_physiolo0.95621139
95MP0008789_abnormal_olfactory_epithelium0.94945169
96MP0008872_abnormal_physiological_respon0.94593354
97MP0010368_abnormal_lymphatic_system0.93489204
98MP0002152_abnormal_brain_morphology0.92726470
99MP0000383_abnormal_hair_follicle0.92392199
100MP0008569_lethality_at_weaning0.92251086
101MP0000920_abnormal_myelination0.89902712
102MP0004811_abnormal_neuron_physiology0.88666134
103MP0008058_abnormal_DNA_repair0.88389401
104MP0009379_abnormal_foot_pigmentation0.87857649
105MP0001324_abnormal_eye_pigmentation0.86834695
106MP0003123_paternal_imprinting0.86111144
107MP0003136_yellow_coat_color0.85880649
108MP0002909_abnormal_adrenal_gland0.85809382
109MP0000647_abnormal_sebaceous_gland0.83463660
110MP0004145_abnormal_muscle_electrophysio0.83423300
111MP0002653_abnormal_ependyma_morphology0.82883748
112MP0004484_altered_response_of0.82696703
113MP0003861_abnormal_nervous_system0.79642289
114MP0000427_abnormal_hair_cycle0.79340245
115MP0001905_abnormal_dopamine_level0.77768592
116MP0001661_extended_life_span0.77434861
117MP0001529_abnormal_vocalization0.76554943
118MP0005623_abnormal_meninges_morphology0.75124703
119MP0002751_abnormal_autonomic_nervous0.75121151
120MP0002233_abnormal_nose_morphology0.69681945
121MP0003122_maternal_imprinting0.68609585
122MP0002822_catalepsy0.67178588
123MP0001299_abnormal_eye_distance/0.66240442
124MP0004085_abnormal_heartbeat0.65151478
125MP0000467_abnormal_esophagus_morphology0.64014630
126MP0001943_abnormal_respiration0.63485796
127MP0001485_abnormal_pinna_reflex0.63399612
128MP0002332_abnormal_exercise_endurance0.61965858
129MP0001986_abnormal_taste_sensitivity0.61295718
130MP0005394_taste/olfaction_phenotype0.59153890
131MP0005499_abnormal_olfactory_system0.59153890
132MP0003942_abnormal_urinary_system0.57612515
133MP0002116_abnormal_craniofacial_bone0.57477544

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.58994301
2Bony spicule pigmentary retinopathy (HP:0007737)5.77131337
3Abnormal rod and cone electroretinograms (HP:0008323)5.26405067
4Abnormality of macular pigmentation (HP:0008002)4.87778088
5Absent rod-and cone-mediated responses on ERG (HP:0007688)4.77683394
6Decreased central vision (HP:0007663)4.71040764
7Central scotoma (HP:0000603)4.66067736
8Focal motor seizures (HP:0011153)4.41791035
9Chorioretinal atrophy (HP:0000533)4.28583194
10Scotoma (HP:0000575)4.23430006
11Attenuation of retinal blood vessels (HP:0007843)4.18664533
12Retinal dysplasia (HP:0007973)3.99404259
13Dyschromatopsia (HP:0007641)3.99150085
14Partial agenesis of the corpus callosum (HP:0001338)3.93170479
15Pigmentary retinal degeneration (HP:0001146)3.58550590
16Pendular nystagmus (HP:0012043)3.49007182
17Upper limb muscle weakness (HP:0003484)3.28072916
18Anterior segment dysgenesis (HP:0007700)3.26991969
19True hermaphroditism (HP:0010459)3.24409266
20Increased corneal curvature (HP:0100692)3.16384487
21Keratoconus (HP:0000563)3.16384487
22Pancreatic cysts (HP:0001737)3.13918876
23Nephronophthisis (HP:0000090)3.11951219
24Pancreatic fibrosis (HP:0100732)3.08696467
25Type II lissencephaly (HP:0007260)3.07777757
26Cone-rod dystrophy (HP:0000548)3.01898166
27Epileptic encephalopathy (HP:0200134)2.98146782
28Abolished electroretinogram (ERG) (HP:0000550)2.96972791
29Choroideremia (HP:0001139)2.94229068
30Febrile seizures (HP:0002373)2.90369235
31Photophobia (HP:0000613)2.86778879
32Intestinal atresia (HP:0011100)2.86084531
33Axonal loss (HP:0003447)2.81756834
34Focal seizures (HP:0007359)2.75793330
35Bundle branch block (HP:0011710)2.71750746
36Progressive external ophthalmoplegia (HP:0000590)2.68642156
37Acute necrotizing encephalopathy (HP:0006965)2.58215970
38Abnormality of the renal medulla (HP:0100957)2.55073685
39Aplasia cutis congenita (HP:0001057)2.54687584
40Optic nerve hypoplasia (HP:0000609)2.54058296
41Prolonged QT interval (HP:0001657)2.53519713
42Abnormality of the labia minora (HP:0012880)2.51756384
43Type II diabetes mellitus (HP:0005978)2.50062954
44Colon cancer (HP:0003003)2.47034891
45Myokymia (HP:0002411)2.41625199
46Conical tooth (HP:0000698)2.37933788
47Acute encephalopathy (HP:0006846)2.34595842
48Anophthalmia (HP:0000528)2.34556955
49Vitreoretinal degeneration (HP:0000655)2.34480958
50Progressive macrocephaly (HP:0004481)2.32160862
51Increased hepatocellular lipid droplets (HP:0006565)2.31833523
52Lipid accumulation in hepatocytes (HP:0006561)2.30634166
53Ulnar claw (HP:0001178)2.29304668
54Cerebellar dysplasia (HP:0007033)2.29215896
55Methylmalonic acidemia (HP:0002912)2.29079290
56Aplasia involving bones of the upper limbs (HP:0009823)2.28648426
57Aplasia of the phalanges of the hand (HP:0009802)2.28648426
58Aplasia involving bones of the extremities (HP:0009825)2.28648426
59Sclerocornea (HP:0000647)2.28137566
60Gait imbalance (HP:0002141)2.27329936
61Syncope (HP:0001279)2.26359751
62Absent/shortened dynein arms (HP:0200106)2.25030540
63Dynein arm defect of respiratory motile cilia (HP:0012255)2.25030540
64Macular degeneration (HP:0000608)2.24812997
65Progressive cerebellar ataxia (HP:0002073)2.24780963
66Retinitis pigmentosa (HP:0000510)2.23198218
67Increased CSF lactate (HP:0002490)2.23112067
68Hyperglycinemia (HP:0002154)2.22613762
69Mitochondrial inheritance (HP:0001427)2.20753774
70Broad-based gait (HP:0002136)2.18251050
71Congenital sensorineural hearing impairment (HP:0008527)2.14724398
72Protruding tongue (HP:0010808)2.13500491
73Hypothermia (HP:0002045)2.12776577
74Hyperventilation (HP:0002883)2.11649542
75Bronchomalacia (HP:0002780)2.10881942
76Abnormal mitochondria in muscle tissue (HP:0008316)2.09839243
77Severe visual impairment (HP:0001141)2.08893711
78Postaxial hand polydactyly (HP:0001162)2.06395322
79Complete atrioventricular canal defect (HP:0001674)2.05400029
80Congenital primary aphakia (HP:0007707)2.04650797
81Septo-optic dysplasia (HP:0100842)2.03952743
82Cystic liver disease (HP:0006706)2.03380503
83Vaginal atresia (HP:0000148)2.02428281
84Excessive salivation (HP:0003781)2.01642603
85Drooling (HP:0002307)2.01642603
86Congenital, generalized hypertrichosis (HP:0004540)2.01583399
87Decreased lacrimation (HP:0000633)2.01578163
88Genital tract atresia (HP:0001827)2.00098061
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00090215
90Abnormality of alanine metabolism (HP:0010916)2.00090215
91Hyperalaninemia (HP:0003348)2.00090215
92Dysdiadochokinesis (HP:0002075)1.99987449
93Visual hallucinations (HP:0002367)1.98707068
94Atonic seizures (HP:0010819)1.97929967
95Nephrogenic diabetes insipidus (HP:0009806)1.97266743
96Midline defect of the nose (HP:0004122)1.96798499
97Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.95957738
98Poor coordination (HP:0002370)1.95796667
99Neoplasm of head and neck (HP:0012288)1.91732111
100Esophageal neoplasm (HP:0100751)1.91732111
101Broad foot (HP:0001769)1.91711504
102Aplasia/Hypoplasia of the tibia (HP:0005772)1.91407934
103Medial flaring of the eyebrow (HP:0010747)1.90747794
104Abnormal respiratory motile cilium morphology (HP:0005938)1.90719043
105Abnormal respiratory epithelium morphology (HP:0012253)1.90719043
106Polyphagia (HP:0002591)1.90606527
107Natal tooth (HP:0000695)1.90467945
108Aplasia/Hypoplasia of the tongue (HP:0010295)1.89948000
109Abnormality of midbrain morphology (HP:0002418)1.89670510
110Molar tooth sign on MRI (HP:0002419)1.89670510
111Hepatocellular necrosis (HP:0001404)1.88099202
112Limb dystonia (HP:0002451)1.88087208
113Confusion (HP:0001289)1.87780849
114Abnormality of the renal cortex (HP:0011035)1.87627688
115Postaxial foot polydactyly (HP:0001830)1.86918193
116Alacrima (HP:0000522)1.86334116
117Hypoplasia of the brainstem (HP:0002365)1.85808286
118Aplasia/Hypoplasia of the brainstem (HP:0007362)1.85808286
119Myelomeningocele (HP:0002475)1.85745904
120Chronic hepatic failure (HP:0100626)1.83799061
121Anencephaly (HP:0002323)1.82063099
122Lissencephaly (HP:0001339)1.81456408
123Gastrointestinal atresia (HP:0002589)1.80821656
124Bradycardia (HP:0001662)1.80768683
125Occipital encephalocele (HP:0002085)1.80400286
126Oligodactyly (hands) (HP:0001180)1.79408432
127Atrioventricular canal defect (HP:0006695)1.78712321
128Hyperinsulinemic hypoglycemia (HP:0000825)1.77876076
129Abnormality of the phalanges of the 2nd finger (HP:0009541)1.77767199
130Abnormality of the corticospinal tract (HP:0002492)1.77492247
131Male pseudohermaphroditism (HP:0000037)1.77012061
132Hemiparesis (HP:0001269)1.76955372
133Short foot (HP:0001773)1.76945546
134Short tibia (HP:0005736)1.76574217
135Renal Fanconi syndrome (HP:0001994)1.76352228
136Inability to walk (HP:0002540)1.76327168
137Rib fusion (HP:0000902)1.75325124
138Hepatic necrosis (HP:0002605)1.74658402
139Abnormality of secondary sexual hair (HP:0009888)1.74227042
140Abnormality of the axillary hair (HP:0100134)1.74227042
141Abnormality of incisor morphology (HP:0011063)1.73332244
142Bifid tongue (HP:0010297)1.72768827
143Specific learning disability (HP:0001328)1.72414011
144Pancreatic islet-cell hyperplasia (HP:0004510)1.72324801
145Glycosuria (HP:0003076)1.71552342
146Abnormality of urine glucose concentration (HP:0011016)1.71552342
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.71071891
148Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71071891
149Cutaneous finger syndactyly (HP:0010554)1.71069544
150Mixed hearing impairment (HP:0000410)1.70929800
151Cupped ear (HP:0000378)1.70861332
152Apathy (HP:0000741)1.70776627
153Methylmalonic aciduria (HP:0012120)1.70237810
154Hyperglycinuria (HP:0003108)1.69488883
155Renal hypoplasia (HP:0000089)1.69165338
156Abnormal drinking behavior (HP:0030082)1.68245793
157Polydipsia (HP:0001959)1.68245793
158Abnormality of the antihelix (HP:0009738)1.67705955
159Mutism (HP:0002300)1.67163826
160Left ventricular hypertrophy (HP:0001712)1.67088621
161Disproportionate short-trunk short stature (HP:0003521)1.65812845
162Abnormal EKG (HP:0003115)1.65182151
163Supernumerary spleens (HP:0009799)1.65121545
164Abnormality of salivation (HP:0100755)1.65059003
165Small hand (HP:0200055)1.64724260
166Narrow forehead (HP:0000341)1.63742523
167Absent speech (HP:0001344)1.63360126
168Dysmetria (HP:0001310)1.63015476
169Optic disc pallor (HP:0000543)1.62657633
170Renal cortical cysts (HP:0000803)1.62043955
171Pachygyria (HP:0001302)1.60973157
172Abnormality of the middle phalanges of the toes (HP:0010183)1.60153905

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.20469298
2CASK3.88594950
3NTRK33.58440906
4PDGFRA3.25890980
5EPHA42.94992163
6FRK2.93381392
7TNIK2.60255492
8MAP4K22.36289259
9GRK12.32984209
10BMPR1B2.27810704
11ZAK2.14268438
12MAP2K42.10194776
13MARK12.07841811
14NUAK12.01192650
15MUSK1.98727496
16MAPK131.96816474
17STK241.92181131
18TRIM281.86415037
19NEK61.85903776
20MAP3K41.81144906
21BCKDK1.77508245
22PAK61.77313035
23MKNK21.72155372
24BCR1.70790285
25PINK11.70432724
26MAP2K71.69927696
27PLK41.60969323
28FES1.56603722
29INSRR1.53499116
30NTRK21.48262403
31SIK21.40395599
32PRKD31.38233633
33WNK41.33516946
34STK161.31216052
35PNCK1.30123434
36DYRK21.29371157
37FGR1.27736850
38OXSR11.26787968
39CSNK1G11.26644991
40PKN11.25700175
41WEE11.22789370
42PLK21.20990838
43MAP3K131.18910528
44ERBB31.18751405
45PDGFRB1.18491529
46STK38L1.16910840
47PLK31.16626405
48VRK21.16476500
49FGFR21.15115133
50CSNK1A1L1.13910922
51CSNK1G31.13441648
52MAPK121.11839716
53PBK1.06457748
54DYRK1A1.04225817
55PHKG21.01581453
56PHKG11.01581453
57TAF11.00671200
58PAK31.00239640
59CDK30.99940429
60CAMK2A0.99857797
61TSSK60.98980696
62PRKD20.95404850
63GRK50.93087462
64MINK10.92956538
65BRD40.91114830
66TNK20.90901704
67RIPK40.89626130
68PRPF4B0.89304999
69TAOK30.87054149
70KSR20.86539647
71ACVR1B0.86038739
72CDK50.85995224
73GRK70.85729200
74TIE10.85324957
75AKT30.85148472
76MAPK70.85064402
77SGK2230.83796481
78SGK4940.83796481
79CAMK2B0.83193854
80KSR10.83097317
81VRK10.82887262
82SGK10.82727194
83YES10.81992143
84PRKCE0.80915158
85CDK190.79440389
86BRSK20.78933099
87PRKCG0.77998412
88EIF2AK30.77644901
89LIMK10.77291953
90PRKCH0.77189670
91MAP3K70.75905080
92CDC42BPA0.72494221
93STK390.71668622
94FLT30.71645682
95NEK10.71586061
96TAOK20.71038953
97WNK30.66907164
98TGFBR10.65757318
99CAMK2D0.64340608
100UHMK10.63917258
101BMPR20.63231603
102PIM20.63067251
103SGK20.62881849
104DDR20.62228491
105MAPK100.61842857
106MKNK10.59284772
107PRKCQ0.59219509
108MST40.58534502
109ADRBK10.57389545
110MAP3K90.57180774
111CSNK1D0.57035773
112CAMK1G0.57007504
113PTK2B0.55441051
114ERBB40.55407717
115STK110.55371549
116SRPK10.54440548
117TYRO30.51084258
118PLK10.51054035
119IRAK20.50991256
120MAP3K60.50981453
121PRKCZ0.50187903
122DAPK20.49860457
123DYRK30.48566223
124MAPKAPK50.46844495
125ERBB20.46592859
126ADRBK20.45481391
127CAMK10.45148925
128PRKACA0.44906929
129FYN0.44604357
130OBSCN0.44540819
131PRKACB0.43945253
132ROCK20.43863467
133RPS6KA30.43842275
134LATS10.43614628
135TLK10.42864775
136FER0.42419431
137PRKAA20.42278511
138CSNK1G20.41601263
139MARK20.41492494
140FGFR10.39946016
141CSNK1A10.39477851
142CDK80.39060749
143MYLK0.38363626
144SIK30.38360069
145WNK10.37833985
146MAP2K60.37665586
147EIF2AK20.37538114
148PRKG10.35045052
149PIK3CA0.34741821

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047447.35405830
2Nicotine addiction_Homo sapiens_hsa050333.55198098
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006033.08252755
4Protein export_Homo sapiens_hsa030602.94050919
5Sulfur relay system_Homo sapiens_hsa041222.79336985
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.50091683
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.49501368
8Glutamatergic synapse_Homo sapiens_hsa047242.39500572
9GABAergic synapse_Homo sapiens_hsa047272.31063159
10Olfactory transduction_Homo sapiens_hsa047402.30369904
11Circadian entrainment_Homo sapiens_hsa047132.18556936
12Propanoate metabolism_Homo sapiens_hsa006402.17419125
13Morphine addiction_Homo sapiens_hsa050322.17081297
14Butanoate metabolism_Homo sapiens_hsa006501.97389631
15Synaptic vesicle cycle_Homo sapiens_hsa047211.95838733
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92085667
17Serotonergic synapse_Homo sapiens_hsa047261.81297288
18Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.75951554
19RNA degradation_Homo sapiens_hsa030181.71602364
20Salivary secretion_Homo sapiens_hsa049701.66005551
21Dopaminergic synapse_Homo sapiens_hsa047281.64332343
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.63365765
23Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.61783971
24Basal transcription factors_Homo sapiens_hsa030221.61534893
25Long-term potentiation_Homo sapiens_hsa047201.59935032
26Insulin secretion_Homo sapiens_hsa049111.59889033
27Amphetamine addiction_Homo sapiens_hsa050311.57887109
28RNA polymerase_Homo sapiens_hsa030201.52916935
29Calcium signaling pathway_Homo sapiens_hsa040201.49864811
30Renin secretion_Homo sapiens_hsa049241.44968541
31Long-term depression_Homo sapiens_hsa047301.44106993
32Taste transduction_Homo sapiens_hsa047421.43516460
33Huntingtons disease_Homo sapiens_hsa050161.42392421
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41160720
35Cholinergic synapse_Homo sapiens_hsa047251.41134250
36Oxytocin signaling pathway_Homo sapiens_hsa049211.36553299
37Axon guidance_Homo sapiens_hsa043601.36074178
38Steroid biosynthesis_Homo sapiens_hsa001001.35342719
39Cocaine addiction_Homo sapiens_hsa050301.33588381
40Nitrogen metabolism_Homo sapiens_hsa009101.33110540
41Gap junction_Homo sapiens_hsa045401.33074741
42Linoleic acid metabolism_Homo sapiens_hsa005911.32445864
43Maturity onset diabetes of the young_Homo sapiens_hsa049501.29708096
44Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.29245054
45Gastric acid secretion_Homo sapiens_hsa049711.27953598
46Peroxisome_Homo sapiens_hsa041461.25159719
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.25137815
48Cardiac muscle contraction_Homo sapiens_hsa042601.22624084
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21913396
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21692602
51Homologous recombination_Homo sapiens_hsa034401.19179907
52Glioma_Homo sapiens_hsa052141.18247938
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.14861490
54Ribosome_Homo sapiens_hsa030101.08665425
55Cysteine and methionine metabolism_Homo sapiens_hsa002701.07660143
56cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05318228
57GnRH signaling pathway_Homo sapiens_hsa049121.05072691
58Lysine degradation_Homo sapiens_hsa003101.03737777
59Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.02817127
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02449124
61Selenocompound metabolism_Homo sapiens_hsa004501.01845760
62beta-Alanine metabolism_Homo sapiens_hsa004101.00413386
63Proteasome_Homo sapiens_hsa030500.99521450
64cAMP signaling pathway_Homo sapiens_hsa040240.99380914
65Dilated cardiomyopathy_Homo sapiens_hsa054140.97273862
66Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95837150
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95488531
68Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94061396
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.93231900
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.92273732
71Arginine and proline metabolism_Homo sapiens_hsa003300.92252450
72Caffeine metabolism_Homo sapiens_hsa002320.91204953
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89496906
74Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89486287
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88826643
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88614534
77Tryptophan metabolism_Homo sapiens_hsa003800.87480355
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.87118868
79ErbB signaling pathway_Homo sapiens_hsa040120.85913499
80Choline metabolism in cancer_Homo sapiens_hsa052310.84692493
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.83400278
82Melanogenesis_Homo sapiens_hsa049160.82370969
83Purine metabolism_Homo sapiens_hsa002300.81836451
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.79098183
85Phosphatidylinositol signaling system_Homo sapiens_hsa040700.78422499
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.77835588
87Ras signaling pathway_Homo sapiens_hsa040140.76715484
88Collecting duct acid secretion_Homo sapiens_hsa049660.76238511
89Retinol metabolism_Homo sapiens_hsa008300.72624317
90Metabolic pathways_Homo sapiens_hsa011000.71095890
91Hedgehog signaling pathway_Homo sapiens_hsa043400.70904793
92Sphingolipid metabolism_Homo sapiens_hsa006000.69018690
93Melanoma_Homo sapiens_hsa052180.68762070
94MAPK signaling pathway_Homo sapiens_hsa040100.68330534
95One carbon pool by folate_Homo sapiens_hsa006700.67964319
96Pyruvate metabolism_Homo sapiens_hsa006200.67927181
97Estrogen signaling pathway_Homo sapiens_hsa049150.67597487
98Non-homologous end-joining_Homo sapiens_hsa034500.66725095
99Pyrimidine metabolism_Homo sapiens_hsa002400.66307475
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.65021796
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63030416
102Wnt signaling pathway_Homo sapiens_hsa043100.62882271
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.62800170
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62155406
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61909378
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.61714283
107Nucleotide excision repair_Homo sapiens_hsa034200.61201110
108RNA transport_Homo sapiens_hsa030130.60142223
109Fatty acid metabolism_Homo sapiens_hsa012120.59024496
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58448562
111Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.57549401
112Folate biosynthesis_Homo sapiens_hsa007900.55607260
113TGF-beta signaling pathway_Homo sapiens_hsa043500.54997579
114Rap1 signaling pathway_Homo sapiens_hsa040150.54819659
115Alzheimers disease_Homo sapiens_hsa050100.53970982
116Vitamin digestion and absorption_Homo sapiens_hsa049770.52993767
117Basal cell carcinoma_Homo sapiens_hsa052170.51297821
118Chemical carcinogenesis_Homo sapiens_hsa052040.51226209
119Oxidative phosphorylation_Homo sapiens_hsa001900.49476056
120Mismatch repair_Homo sapiens_hsa034300.48520216
121Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47694046
122Glutathione metabolism_Homo sapiens_hsa004800.46863775
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46311347
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.46163974
125Type II diabetes mellitus_Homo sapiens_hsa049300.44074500
126Regulation of autophagy_Homo sapiens_hsa041400.43976521
127Arachidonic acid metabolism_Homo sapiens_hsa005900.43560477
128Pancreatic secretion_Homo sapiens_hsa049720.43503015
129ABC transporters_Homo sapiens_hsa020100.42836744
130Inositol phosphate metabolism_Homo sapiens_hsa005620.42030292
131African trypanosomiasis_Homo sapiens_hsa051430.41948969
132Alcoholism_Homo sapiens_hsa050340.40690473
133Ovarian steroidogenesis_Homo sapiens_hsa049130.37758638
134Circadian rhythm_Homo sapiens_hsa047100.37018966
135Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.36345888
136Histidine metabolism_Homo sapiens_hsa003400.35722049
137Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35100390
138Tight junction_Homo sapiens_hsa045300.33795947
139Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.32760731
140Fanconi anemia pathway_Homo sapiens_hsa034600.31681664
141Central carbon metabolism in cancer_Homo sapiens_hsa052300.31179428
142Sphingolipid signaling pathway_Homo sapiens_hsa040710.29102588
143Vibrio cholerae infection_Homo sapiens_hsa051100.27893682
144Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27644029
145Prion diseases_Homo sapiens_hsa050200.26385988
146Dorso-ventral axis formation_Homo sapiens_hsa043200.26014330
147Thyroid hormone synthesis_Homo sapiens_hsa049180.25253663
148Fatty acid elongation_Homo sapiens_hsa000620.23216144
149Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23119250
150Glycerolipid metabolism_Homo sapiens_hsa005610.23086590
151Hippo signaling pathway_Homo sapiens_hsa043900.21575989
152Ether lipid metabolism_Homo sapiens_hsa005650.20102483
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19342813
154Glucagon signaling pathway_Homo sapiens_hsa049220.19152448
155Renal cell carcinoma_Homo sapiens_hsa052110.18324916
156Parkinsons disease_Homo sapiens_hsa050120.17773385

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