TMEM138

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.03265334
2mitotic metaphase plate congression (GO:0007080)4.72134944
3DNA strand elongation involved in DNA replication (GO:0006271)4.65955602
4telomere maintenance via semi-conservative replication (GO:0032201)4.65268472
5ribosomal small subunit assembly (GO:0000028)4.55386627
6DNA strand elongation (GO:0022616)4.44167437
7CENP-A containing nucleosome assembly (GO:0034080)4.41247767
8telomere maintenance via recombination (GO:0000722)4.17647877
9chromatin remodeling at centromere (GO:0031055)4.17005718
10establishment of chromosome localization (GO:0051303)4.14273526
11metaphase plate congression (GO:0051310)4.10914146
12tryptophan catabolic process (GO:0006569)4.08262742
13indole-containing compound catabolic process (GO:0042436)4.08262742
14indolalkylamine catabolic process (GO:0046218)4.08262742
15kynurenine metabolic process (GO:0070189)4.06229015
16DNA replication initiation (GO:0006270)4.04023347
17proteasome assembly (GO:0043248)3.93811353
18kinetochore organization (GO:0051383)3.91006798
19formation of translation preinitiation complex (GO:0001731)3.88464746
20mitotic recombination (GO:0006312)3.86599950
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.80506901
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.76979701
23DNA replication-independent nucleosome assembly (GO:0006336)3.74969168
24DNA replication-independent nucleosome organization (GO:0034724)3.74969168
25anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.72117510
26regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.71128148
27nucleobase biosynthetic process (GO:0046112)3.70945352
28attachment of spindle microtubules to kinetochore (GO:0008608)3.68820056
29respiratory chain complex IV assembly (GO:0008535)3.67473100
30positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.67450741
31kinetochore assembly (GO:0051382)3.64276841
32protein complex biogenesis (GO:0070271)3.64228845
33mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63552091
34mitochondrial respiratory chain complex I assembly (GO:0032981)3.63552091
35NADH dehydrogenase complex assembly (GO:0010257)3.63552091
36DNA replication checkpoint (GO:0000076)3.63255532
37telomere maintenance via telomere lengthening (GO:0010833)3.61825458
38mitotic sister chromatid segregation (GO:0000070)3.60052435
39protein localization to kinetochore (GO:0034501)3.59993319
407-methylguanosine mRNA capping (GO:0006370)3.58024124
41RNA capping (GO:0036260)3.55853399
427-methylguanosine RNA capping (GO:0009452)3.55853399
43IMP biosynthetic process (GO:0006188)3.50804922
44mitochondrial respiratory chain complex assembly (GO:0033108)3.50468685
45cytochrome complex assembly (GO:0017004)3.50214545
46histone exchange (GO:0043486)3.50003746
47pseudouridine synthesis (GO:0001522)3.49261685
48tryptophan metabolic process (GO:0006568)3.48262860
49spliceosomal snRNP assembly (GO:0000387)3.47873996
50nucleotide-excision repair, DNA gap filling (GO:0006297)3.46103449
51negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.45057099
52negative regulation of ligase activity (GO:0051352)3.45057099
53DNA unwinding involved in DNA replication (GO:0006268)3.44031125
54rRNA methylation (GO:0031167)3.43610775
55histone H2A acetylation (GO:0043968)3.42154493
56transcription-coupled nucleotide-excision repair (GO:0006283)3.41224847
57preassembly of GPI anchor in ER membrane (GO:0016254)3.38152752
58cullin deneddylation (GO:0010388)3.36500836
59viral mRNA export from host cell nucleus (GO:0046784)3.36152514
60purine nucleobase biosynthetic process (GO:0009113)3.34267088
61L-fucose catabolic process (GO:0042355)3.34138181
62fucose catabolic process (GO:0019317)3.34138181
63L-fucose metabolic process (GO:0042354)3.34138181
64ribosome biogenesis (GO:0042254)3.32029884
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.31837504
66mitotic nuclear envelope disassembly (GO:0007077)3.31124591
67positive regulation of prostaglandin secretion (GO:0032308)3.29294248
68sister chromatid segregation (GO:0000819)3.29131666
69signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.26703372
70intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.26703372
71signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26254273
72signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26254273
73signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26254273
74negative regulation of mast cell activation (GO:0033004)3.26072682
75maturation of SSU-rRNA (GO:0030490)3.23727897
76platelet dense granule organization (GO:0060155)3.23085528
77protein localization to chromosome, centromeric region (GO:0071459)3.23061459
78protein deneddylation (GO:0000338)3.22774618
79exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22253912
80indolalkylamine metabolic process (GO:0006586)3.21889329
81positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.20454839
82mannosylation (GO:0097502)3.19587778
83signal transduction involved in DNA integrity checkpoint (GO:0072401)3.16612301
84signal transduction involved in DNA damage checkpoint (GO:0072422)3.16612301
85maturation of 5.8S rRNA (GO:0000460)3.15858515
86ribonucleoprotein complex biogenesis (GO:0022613)3.15824449
87G1/S transition of mitotic cell cycle (GO:0000082)3.13275868
88cell cycle G1/S phase transition (GO:0044843)3.13275868
89signal transduction involved in cell cycle checkpoint (GO:0072395)3.12473133
90polyketide metabolic process (GO:0030638)3.12401832
91doxorubicin metabolic process (GO:0044598)3.12401832
92daunorubicin metabolic process (GO:0044597)3.12401832
93antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.11810407
94nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.11722707
95amine catabolic process (GO:0009310)3.11103848
96cellular biogenic amine catabolic process (GO:0042402)3.11103848
97termination of RNA polymerase III transcription (GO:0006386)3.08676053
98transcription elongation from RNA polymerase III promoter (GO:0006385)3.08676053
99regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.07838556
100telomere maintenance (GO:0000723)3.06608283
101viral transcription (GO:0019083)3.06403848
102positive regulation of ligase activity (GO:0051351)3.06329815
103ribosomal large subunit biogenesis (GO:0042273)3.05728760
104telomere organization (GO:0032200)3.05318724
105deoxyribonucleotide biosynthetic process (GO:0009263)3.05270870
106regulation of cellular amino acid metabolic process (GO:0006521)3.04392482
107negative regulation of interleukin-12 production (GO:0032695)3.04150457
108mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.04095378
109positive regulation of defense response to virus by host (GO:0002230)3.03722574
110spliceosomal complex assembly (GO:0000245)3.02185284
111translational termination (GO:0006415)3.01262180
112energy coupled proton transport, down electrochemical gradient (GO:0015985)3.00082994
113ATP synthesis coupled proton transport (GO:0015986)3.00082994
114regulation of double-strand break repair via homologous recombination (GO:0010569)2.99915527
115regulation of spindle organization (GO:0090224)2.99786440
116nuclear envelope disassembly (GO:0051081)2.99731845
117membrane disassembly (GO:0030397)2.99731845
118meiotic chromosome segregation (GO:0045132)2.99594866
119rRNA modification (GO:0000154)2.99007511
120establishment of integrated proviral latency (GO:0075713)2.97691972
121termination of RNA polymerase I transcription (GO:0006363)2.97544994
122SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.97258842
123rRNA processing (GO:0006364)2.95990164
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.95755432
125establishment of protein localization to mitochondrial membrane (GO:0090151)2.95573347
126regulation of mononuclear cell migration (GO:0071675)2.95040442
127DNA replication-dependent nucleosome assembly (GO:0006335)2.94970032
128DNA replication-dependent nucleosome organization (GO:0034723)2.94970032
129sequestering of actin monomers (GO:0042989)2.94488406
130IMP metabolic process (GO:0046040)2.94442471
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.94109922
132negative regulation of mitotic sister chromatid segregation (GO:0033048)2.93562581
133negative regulation of sister chromatid segregation (GO:0033046)2.93562581
134C-terminal protein lipidation (GO:0006501)2.91956794
135negative regulation of interleukin-1 beta production (GO:0032691)2.89768534
136water-soluble vitamin biosynthetic process (GO:0042364)2.88767118
137regulation of chronic inflammatory response (GO:0002676)2.87381196
138positive regulation of chemokine biosynthetic process (GO:0045080)2.81202569
139behavioral response to nicotine (GO:0035095)2.80500767
140negative regulation of telomere maintenance (GO:0032205)2.78803607
141cytidine deamination (GO:0009972)2.77648413
142cytidine metabolic process (GO:0046087)2.77648413
143cytidine catabolic process (GO:0006216)2.77648413
144protein-cofactor linkage (GO:0018065)2.77041428
145ubiquinone biosynthetic process (GO:0006744)2.74648965
146piRNA metabolic process (GO:0034587)2.73616799
147electron transport chain (GO:0022900)2.72981268
148response to xenobiotic stimulus (GO:0009410)2.71461699
149respiratory electron transport chain (GO:0022904)2.67291955
150C-terminal protein amino acid modification (GO:0018410)2.65543622
151cellular response to exogenous dsRNA (GO:0071360)2.64928773
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.62625968
153tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.62625968
154NAD biosynthetic process (GO:0009435)2.58849531
155tRNA processing (GO:0008033)2.57937897
156regulation of prostaglandin secretion (GO:0032306)2.57256963
157negative regulation of interleukin-1 production (GO:0032692)2.55985172
158response to pheromone (GO:0019236)2.54766101
159proton transport (GO:0015992)2.53963363
160hydrogen ion transmembrane transport (GO:1902600)2.51448385
161epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.50551690
162cellular ketone body metabolic process (GO:0046950)2.49351792
163hydrogen transport (GO:0006818)2.47817210
164mitochondrial RNA metabolic process (GO:0000959)2.44819054
165energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.42917111
166ATP hydrolysis coupled proton transport (GO:0015991)2.42917111
167regulation of chemokine biosynthetic process (GO:0045073)2.41650118
168pyrimidine ribonucleoside catabolic process (GO:0046133)2.41155289
169ketone body metabolic process (GO:1902224)2.39697680
170aromatic amino acid family catabolic process (GO:0009074)2.38486491
171negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37521957
172protein neddylation (GO:0045116)2.37232684
173eosinophil chemotaxis (GO:0048245)2.36351287
174pyrimidine-containing compound transmembrane transport (GO:0072531)2.33351440
175chaperone-mediated protein transport (GO:0072321)2.33081480
176metallo-sulfur cluster assembly (GO:0031163)2.32077220
177iron-sulfur cluster assembly (GO:0016226)2.32077220
178ubiquinone metabolic process (GO:0006743)2.32008341
179signal peptide processing (GO:0006465)2.30814418
180regulation of vitamin D biosynthetic process (GO:0060556)2.30110318
181negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.27780972
182RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.27361031
183tRNA modification (GO:0006400)2.26806814
184oligosaccharide catabolic process (GO:0009313)2.24852438
185L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.24813998

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.37941145
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.22430348
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.01325007
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.78995078
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.58989781
6ZNF274_21170338_ChIP-Seq_K562_Hela3.58829248
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.56494169
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.47619485
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.41804788
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.38683719
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.29952898
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.23648916
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.19641697
14IRF8_21731497_ChIP-ChIP_J774_Mouse3.12694085
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06532476
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05666884
17ETS1_20019798_ChIP-Seq_JURKAT_Human3.02833414
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01046346
19VDR_22108803_ChIP-Seq_LS180_Human2.99683970
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.87223487
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.72625988
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61731242
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53251934
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52995111
25VDR_23849224_ChIP-Seq_CD4+_Human2.51684743
26XRN2_22483619_ChIP-Seq_HELA_Human2.39520842
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35396533
28FOXP3_21729870_ChIP-Seq_TREG_Human2.35218305
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34990550
30* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.28619639
31DCP1A_22483619_ChIP-Seq_HELA_Human2.27711517
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.25429000
33* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.22163600
34GABP_19822575_ChIP-Seq_HepG2_Human2.08775201
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07694219
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.06471435
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.06188536
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04719072
39YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01002388
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.97448338
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.95032226
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94696407
43ELK1_19687146_ChIP-ChIP_HELA_Human1.92465858
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.90160635
45TTF2_22483619_ChIP-Seq_HELA_Human1.89180745
46AR_21909140_ChIP-Seq_LNCAP_Human1.88416469
47HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84132847
48CIITA_25753668_ChIP-Seq_RAJI_Human1.83560986
49CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.80914960
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76304261
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.74964013
52PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74685092
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.74326112
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72799448
55* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72278196
56MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67409716
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.65541308
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.61994605
59GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61087729
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.59859041
61* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.58236966
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.56193850
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.54800150
64ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52372250
65GATA3_26560356_Chip-Seq_TH2_Human1.52328950
66E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.51117980
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.50842268
68IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48638621
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.46814908
70FLI1_27457419_Chip-Seq_LIVER_Mouse1.45879836
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43506147
72TP53_22573176_ChIP-Seq_HFKS_Human1.40303515
73EWS_26573619_Chip-Seq_HEK293_Human1.38225527
74KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35358151
75* KDM5A_27292631_Chip-Seq_BREAST_Human1.34178930
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32543526
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.30798217
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.30768251
79GATA3_21878914_ChIP-Seq_MCF-7_Human1.30751109
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29839668
81POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29140689
82* FOXA1_25329375_ChIP-Seq_VCAP_Human1.27460566
83* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27460566
84* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.24412349
85IRF8_27001747_Chip-Seq_BMDM_Mouse1.23846404
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.22940192
87ER_23166858_ChIP-Seq_MCF-7_Human1.21760627
88PCGF2_27294783_Chip-Seq_ESCs_Mouse1.19339572
89MYC_22102868_ChIP-Seq_BL_Human1.17841531
90ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17678909
91* AR_20517297_ChIP-Seq_VCAP_Human1.16520062
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16086446
93STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.11824832
94EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.11626932
95NOTCH1_21737748_ChIP-Seq_TLL_Human1.11623272
96STAT4_19710469_ChIP-ChIP_TH1__Mouse1.11328224
97MYC_18940864_ChIP-ChIP_HL60_Human1.10671895
98GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.09658264
99* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08910326
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.07694518
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07178534
102NANOG_19829295_ChIP-Seq_ESCs_Human1.06417107
103SOX2_19829295_ChIP-Seq_ESCs_Human1.06417107
104ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05947285
105CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.05606080
106HOXB7_26014856_ChIP-Seq_BT474_Human1.04484787
107TAF2_19829295_ChIP-Seq_ESCs_Human1.03713976
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.03511107
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03341029
110* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02488742
111IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02236154
112TFEB_21752829_ChIP-Seq_HELA_Human1.01603531
113PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.01486043
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01126339
115NCOR_22424771_ChIP-Seq_293T_Human1.00796366
116STAT1_20625510_ChIP-Seq_HELA_Human0.99148879
117SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99010801
118SPI1_23547873_ChIP-Seq_NB4_Human0.97517412
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.97214017
120ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97211063
121CTBP1_25329375_ChIP-Seq_LNCAP_Human0.97009216
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96585479
123* MYC_19829295_ChIP-Seq_ESCs_Human0.96367096
124* ERA_21632823_ChIP-Seq_H3396_Human0.94277166
125GATA3_26560356_Chip-Seq_TH1_Human0.93802424
126NANOG_20526341_ChIP-Seq_ESCs_Human0.92994571
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.92132783
128RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.92027303
129KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.91998501
130IRF1_19129219_ChIP-ChIP_H3396_Human0.91074380
131IGF1R_20145208_ChIP-Seq_DFB_Human0.91031566
132CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89999124
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.89306044
134RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.89096594
135TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.88719205
136CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.88591719
137BCAT_22108803_ChIP-Seq_LS180_Human0.87916073
138CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87443154
139MYB_26560356_Chip-Seq_TH2_Human0.86755440
140FOXH1_21741376_ChIP-Seq_EPCs_Human0.86571941
141TAF15_26573619_Chip-Seq_HEK293_Human0.86414748
142CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85938291
143MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.85784147
144ELF5_23300383_ChIP-Seq_T47D_Human0.85262854
145GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85114063
146POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84908710
147NFE2_27457419_Chip-Seq_LIVER_Mouse0.84304640
148CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83700052
149* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82655539
150DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.82204271
151KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82153887
152* NANOG_21062744_ChIP-ChIP_HESCs_Human0.80250913
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.79369062
154SOX17_20123909_ChIP-Seq_XEN_Mouse0.73366381
155STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73326670
156VDR_21846776_ChIP-Seq_THP-1_Human0.71754495
157RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.71604605
158MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.68815753

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35381630
2MP0004957_abnormal_blastocyst_morpholog4.43098437
3MP0010094_abnormal_chromosome_stability4.36403048
4MP0003111_abnormal_nucleus_morphology4.13417630
5MP0003077_abnormal_cell_cycle4.05821064
6MP0008058_abnormal_DNA_repair3.75680302
7MP0008007_abnormal_cellular_replicative3.71982551
8MP0003806_abnormal_nucleotide_metabolis3.63865443
9MP0003195_calcinosis3.20380493
10MP0005671_abnormal_response_to3.08866863
11MP0008057_abnormal_DNA_replication2.88496845
12MP0002148_abnormal_hypersensitivity_rea2.87677841
13MP0009785_altered_susceptibility_to2.80841546
14MP0008932_abnormal_embryonic_tissue2.61830508
15MP0006292_abnormal_olfactory_placode2.53316542
16MP0008875_abnormal_xenobiotic_pharmacok2.49222010
17MP0006082_CNS_inflammation2.48284216
18MP0002396_abnormal_hematopoietic_system2.35226576
19MP0009840_abnormal_foam_cell2.34351084
20MP0003123_paternal_imprinting2.27636627
21MP0010030_abnormal_orbit_morphology2.26214148
22MP0008877_abnormal_DNA_methylation2.25310927
23MP0002837_dystrophic_cardiac_calcinosis2.22247361
24MP0005058_abnormal_lysosome_morphology2.17051739
25MP0005387_immune_system_phenotype2.12943169
26MP0001790_abnormal_immune_system2.12943169
27MP0003786_premature_aging2.10783070
28MP0009764_decreased_sensitivity_to2.10726066
29MP0003011_delayed_dark_adaptation1.95748432
30MP0001800_abnormal_humoral_immune1.90056930
31MP0003172_abnormal_lysosome_physiology1.88196061
32MP0001730_embryonic_growth_arrest1.85626780
33MP0000350_abnormal_cell_proliferation1.85400086
34MP0005000_abnormal_immune_tolerance1.84350112
35MP0002139_abnormal_hepatobiliary_system1.81266935
36MP0003183_abnormal_peptide_metabolism1.79932277
37MP0002277_abnormal_respiratory_mucosa1.78604130
38MP0002452_abnormal_antigen_presenting1.78379471
39MP0000015_abnormal_ear_pigmentation1.77389653
40MP0002102_abnormal_ear_morphology1.77086172
41MP0002419_abnormal_innate_immunity1.75641138
42MP0002723_abnormal_immune_serum1.72392532
43MP0004808_abnormal_hematopoietic_stem1.71060569
44MP0005025_abnormal_response_to1.68026545
45MP0000569_abnormal_digit_pigmentation1.65808714
46MP0009379_abnormal_foot_pigmentation1.63902525
47MP0003436_decreased_susceptibility_to1.59494520
48MP0000490_abnormal_crypts_of1.57996162
49MP0005167_abnormal_blood-brain_barrier1.57530563
50MP0002138_abnormal_hepatobiliary_system1.54614907
51MP0000371_diluted_coat_color1.52643649
52MP0003718_maternal_effect1.51108996
53MP0005310_abnormal_salivary_gland1.49281120
54MP0003763_abnormal_thymus_physiology1.47580593
55MP0002420_abnormal_adaptive_immunity1.46340563
56MP0003567_abnormal_fetal_cardiomyocyte1.46325499
57MP0001819_abnormal_immune_cell1.44532808
58MP0001845_abnormal_inflammatory_respons1.43532516
59MP0010307_abnormal_tumor_latency1.43312694
60MP0001697_abnormal_embryo_size1.39883948
61MP0002405_respiratory_system_inflammati1.39286949
62MP0003646_muscle_fatigue1.39198255
63MP0002019_abnormal_tumor_incidence1.35357671
64MP0000343_altered_response_to1.34410122
65MP0003121_genomic_imprinting1.33632675
66MP0001873_stomach_inflammation1.33101377
67MP0000313_abnormal_cell_death1.32900042
68MP0005645_abnormal_hypothalamus_physiol1.32151600
69MP0000372_irregular_coat_pigmentation1.32084439
70MP0008469_abnormal_protein_level1.32004034
71MP0003724_increased_susceptibility_to1.30792384
72MP0002080_prenatal_lethality1.28699388
73MP0002095_abnormal_skin_pigmentation1.26579747
74MP0002638_abnormal_pupillary_reflex1.25902684
75MP0005174_abnormal_tail_pigmentation1.25572949
76MP0001529_abnormal_vocalization1.25091831
77MP0001672_abnormal_embryogenesis/_devel1.24813575
78MP0005380_embryogenesis_phenotype1.24813575
79MP0009333_abnormal_splenocyte_physiolog1.24140398
80MP0005551_abnormal_eye_electrophysiolog1.22816453
81MP0005410_abnormal_fertilization1.21815150
82MP0004043_abnormal_pH_regulation1.21757208
83MP0002160_abnormal_reproductive_system1.17421703
84MP0003984_embryonic_growth_retardation1.16417279
85MP0002132_abnormal_respiratory_system1.13712528
86MP0003890_abnormal_embryonic-extraembry1.12710760
87MP0001545_abnormal_hematopoietic_system1.12120815
88MP0005397_hematopoietic_system_phenotyp1.12120815
89MP0002398_abnormal_bone_marrow1.11121146
90MP0005365_abnormal_bile_salt1.10568491
91MP0002088_abnormal_embryonic_growth/wei1.09338654
92MP0005408_hypopigmentation1.09161518
93MP0001293_anophthalmia1.07211740
94MP0002876_abnormal_thyroid_physiology1.07000350
95MP0003186_abnormal_redox_activity1.06425877
96MP0004133_heterotaxia1.06089154
97MP0002085_abnormal_embryonic_tissue1.05562787
98MP0006036_abnormal_mitochondrial_physio1.04308791
99MP0000703_abnormal_thymus_morphology1.04105427
100MP0002210_abnormal_sex_determination1.03451695
101MP0001835_abnormal_antigen_presentation1.02525119
102MP0005075_abnormal_melanosome_morpholog1.02395034
103MP0002163_abnormal_gland_morphology1.02279882
104MP0005084_abnormal_gallbladder_morpholo1.01470054
105MP0003315_abnormal_perineum_morphology1.01279478
106MP0001764_abnormal_homeostasis0.99872404
107MP0000427_abnormal_hair_cycle0.99665134
108MP0002751_abnormal_autonomic_nervous0.98610625
109MP0004142_abnormal_muscle_tone0.98145450
110MP0000358_abnormal_cell_content/0.96204139
111MP0010386_abnormal_urinary_bladder0.95882218
112MP0000681_abnormal_thyroid_gland0.95622555
113MP0005389_reproductive_system_phenotype0.95534485
114MP0003943_abnormal_hepatobiliary_system0.95527712
115MP0001533_abnormal_skeleton_physiology0.95497441
116MP0009697_abnormal_copulation0.95156050
117MP0006054_spinal_hemorrhage0.94689939
118MP0009046_muscle_twitch0.94497359
119MP0000689_abnormal_spleen_morphology0.94154532
120MP0002722_abnormal_immune_system0.92449796
121MP0001324_abnormal_eye_pigmentation0.91849628
122MP0001119_abnormal_female_reproductive0.91429477
123MP0008872_abnormal_physiological_respon0.91123775
124MP0001145_abnormal_male_reproductive0.91054789
125MP0003950_abnormal_plasma_membrane0.88585746
126MP0005379_endocrine/exocrine_gland_phen0.88343081
127MP0003136_yellow_coat_color0.88193963
128MP0002938_white_spotting0.88171549
129MP0002693_abnormal_pancreas_physiology0.87439797
130MP0010155_abnormal_intestine_physiology0.86633196
131MP0005647_abnormal_sex_gland0.83289400
132MP0008789_abnormal_olfactory_epithelium0.82966758
133MP0002429_abnormal_blood_cell0.82779489
134MP0003075_altered_response_to0.82141029
135MP0001188_hyperpigmentation0.82125985
136MP0001905_abnormal_dopamine_level0.82086451
137MP0001663_abnormal_digestive_system0.82027522
138MP0001929_abnormal_gametogenesis0.80310304
139MP0002084_abnormal_developmental_patter0.80020757
140MP0000566_synostosis0.79919855
141MP0002086_abnormal_extraembryonic_tissu0.79890268
142MP0002254_reproductive_system_inflammat0.79844127
143MP0000049_abnormal_middle_ear0.79560015
144MP0005319_abnormal_enzyme/_coenzyme0.79031031
145MP0001919_abnormal_reproductive_system0.78378387
146MP0000653_abnormal_sex_gland0.78309745
147MP0001853_heart_inflammation0.76866828
148MP0004019_abnormal_vitamin_homeostasis0.75455183
149MP0006035_abnormal_mitochondrial_morpho0.75239393
150MP0005332_abnormal_amino_acid0.73648945
151MP0004742_abnormal_vestibular_system0.73503689
152MP0005253_abnormal_eye_physiology0.73335727
153MP0008995_early_reproductive_senescence0.73151320
154MP0001501_abnormal_sleep_pattern0.72717345
155MP0000858_altered_metastatic_potential0.72668628
156MP0002090_abnormal_vision0.72646929
157MP0000678_abnormal_parathyroid_gland0.72523793
158MP0001485_abnormal_pinna_reflex0.72307751
159MP0000604_amyloidosis0.71699427
160MP0001986_abnormal_taste_sensitivity0.70914459
161MP0000716_abnormal_immune_system0.70248977
162MP0005384_cellular_phenotype0.70120090
163MP0002653_abnormal_ependyma_morphology0.69332715
164MP0006072_abnormal_retinal_apoptosis0.69180959
165MP0003122_maternal_imprinting0.67700931
166MP0000685_abnormal_immune_system0.67370387
167MP0002932_abnormal_joint_morphology0.66238716
168MP0004147_increased_porphyrin_level0.66118666
169MP0004197_abnormal_fetal_growth/weight/0.65488741
170MP0010352_gastrointestinal_tract_polyps0.63986214

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.15152911
2Abnormality of liposaccharide metabolism (HP:0010968)4.10992307
3Abnormality of glycosphingolipid metabolism (HP:0004343)4.10992307
4Abnormality of glycolipid metabolism (HP:0010969)4.10992307
5Birth length less than 3rd percentile (HP:0003561)4.01533248
6Abnormal number of erythroid precursors (HP:0012131)3.86171105
7Vacuolated lymphocytes (HP:0001922)3.81617562
8Reticulocytopenia (HP:0001896)3.76918648
9Abnormality of cells of the erythroid lineage (HP:0012130)3.68839610
1011 pairs of ribs (HP:0000878)3.59164811
11Abnormal lung lobation (HP:0002101)3.42503236
12Chromsome breakage (HP:0040012)3.34991283
13Chromosomal breakage induced by crosslinking agents (HP:0003221)3.18955532
14Colon cancer (HP:0003003)3.10723110
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.08971010
16Increased cerebral lipofuscin (HP:0011813)3.07763183
17Oral leukoplakia (HP:0002745)3.03195438
18Meckel diverticulum (HP:0002245)3.00268092
19Breast hypoplasia (HP:0003187)2.99953550
20Hyperalaninemia (HP:0003348)2.97735916
21Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.97735916
22Abnormality of alanine metabolism (HP:0010916)2.97735916
23Congenital stationary night blindness (HP:0007642)2.96208923
24Type 2 muscle fiber atrophy (HP:0003554)2.91312388
25Abnormality of the ileum (HP:0001549)2.89125236
26Patellar aplasia (HP:0006443)2.86967007
27Degeneration of anterior horn cells (HP:0002398)2.86836989
28Abnormality of the anterior horn cell (HP:0006802)2.86836989
29Duodenal stenosis (HP:0100867)2.86288511
30Small intestinal stenosis (HP:0012848)2.86288511
31* Molar tooth sign on MRI (HP:0002419)2.83966468
32* Abnormality of midbrain morphology (HP:0002418)2.83966468
33Type I transferrin isoform profile (HP:0003642)2.82601602
34Acute encephalopathy (HP:0006846)2.82089149
35Abnormality of the preputium (HP:0100587)2.80786145
36Muscle fiber atrophy (HP:0100295)2.80325658
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.80226096
38Stomatitis (HP:0010280)2.78879608
39Myelodysplasia (HP:0002863)2.76168070
40Cutaneous melanoma (HP:0012056)2.73828700
41Abnormality of chromosome stability (HP:0003220)2.68495794
42Progressive macrocephaly (HP:0004481)2.66433359
43Aplasia/Hypoplasia of the patella (HP:0006498)2.61121105
44Abnormality of the pons (HP:0007361)2.59721891
45Medulloblastoma (HP:0002885)2.59370082
46Hypoplasia of the pons (HP:0012110)2.55144300
47Selective tooth agenesis (HP:0001592)2.54345693
483-Methylglutaconic aciduria (HP:0003535)2.53410464
49Thrombocytosis (HP:0001894)2.46056574
50Abnormality of the duodenum (HP:0002246)2.44951001
51Rough bone trabeculation (HP:0100670)2.40670544
52Absent/shortened dynein arms (HP:0200106)2.40483369
53Dynein arm defect of respiratory motile cilia (HP:0012255)2.40483369
54Hepatocellular necrosis (HP:0001404)2.39788599
55Increased hepatocellular lipid droplets (HP:0006565)2.39597530
56Lipid accumulation in hepatocytes (HP:0006561)2.39514567
57Renal Fanconi syndrome (HP:0001994)2.37379345
58Type II lissencephaly (HP:0007260)2.34962537
59Hepatic necrosis (HP:0002605)2.33064361
60Optic disc pallor (HP:0000543)2.31588511
61Hyperventilation (HP:0002883)2.31018861
62Agnosia (HP:0010524)2.30921682
63Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30824598
64Bone marrow hypocellularity (HP:0005528)2.30693298
65Missing ribs (HP:0000921)2.29205747
66IgM deficiency (HP:0002850)2.28558321
67Aplasia/Hypoplasia of the sacrum (HP:0008517)2.27281715
68Sloping forehead (HP:0000340)2.26085238
69Abnormality of the renal cortex (HP:0011035)2.21949983
70Microretrognathia (HP:0000308)2.21488704
71Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.21112084
72Spinal cord lesions (HP:0100561)2.21111323
73Syringomyelia (HP:0003396)2.21111323
74Abolished electroretinogram (ERG) (HP:0000550)2.21047968
75Rhabdomyosarcoma (HP:0002859)2.19952445
76Attenuation of retinal blood vessels (HP:0007843)2.19352505
77Optic nerve coloboma (HP:0000588)2.18220573
78Large for gestational age (HP:0001520)2.17250713
79Carpal bone hypoplasia (HP:0001498)2.16724836
80Acute necrotizing encephalopathy (HP:0006965)2.16051783
81True hermaphroditism (HP:0010459)2.14516338
82Premature graying of hair (HP:0002216)2.12966301
83Severe visual impairment (HP:0001141)2.12363968
84Pallor (HP:0000980)2.10785104
85Pancreatic cysts (HP:0001737)2.10706510
86Abnormal biliary tract physiology (HP:0012439)2.10341549
87Bile duct proliferation (HP:0001408)2.10341549
88Absent thumb (HP:0009777)2.09947621
89Tubular atrophy (HP:0000092)2.08821308
90Cerebral hypomyelination (HP:0006808)2.08364884
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.08130719
92Elevated erythrocyte sedimentation rate (HP:0003565)2.06245724
93Microvesicular hepatic steatosis (HP:0001414)2.05978666
94Abnormal mitochondria in muscle tissue (HP:0008316)2.04663051
95Increased serum lactate (HP:0002151)2.04538914
96Triphalangeal thumb (HP:0001199)2.02192092
97Mutism (HP:0002300)2.01839238
98Decreased activity of mitochondrial respiratory chain (HP:0008972)2.01285353
99Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.01285353
100Lactic acidosis (HP:0003128)2.01180024
101* Nephronophthisis (HP:0000090)2.00769013
102Albinism (HP:0001022)1.99861511
103Abnormal respiratory motile cilium morphology (HP:0005938)1.99795314
104Abnormal respiratory epithelium morphology (HP:0012253)1.99795314
105Increased serum ferritin (HP:0003281)1.99231510
106Tracheoesophageal fistula (HP:0002575)1.99126064
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98599895
108IgG deficiency (HP:0004315)1.98528948
109Pendular nystagmus (HP:0012043)1.97790032
110Supernumerary spleens (HP:0009799)1.97353747
111Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.97190423
112Abnormal protein N-linked glycosylation (HP:0012347)1.97190423
113Abnormal protein glycosylation (HP:0012346)1.97190423
114Abnormal glycosylation (HP:0012345)1.97190423
115Abnormality of the heme biosynthetic pathway (HP:0010472)1.96954769
116Mitochondrial inheritance (HP:0001427)1.96799815
117Macrocytic anemia (HP:0001972)1.96586452
118Prominent metopic ridge (HP:0005487)1.96215099
119Respiratory failure (HP:0002878)1.95650323
120Congenital, generalized hypertrichosis (HP:0004540)1.95116375
121Dysostosis multiplex (HP:0000943)1.95038548
122Increased CSF lactate (HP:0002490)1.94868759
123Intestinal atresia (HP:0011100)1.92982345
124Lymphoma (HP:0002665)1.92917312
125Aplasia/hypoplasia of the uterus (HP:0008684)1.92756936
126Panhypogammaglobulinemia (HP:0003139)1.92453337
127Pancytopenia (HP:0001876)1.92345458
128Polydipsia (HP:0001959)1.91722665
129Abnormal drinking behavior (HP:0030082)1.91722665
130Pancreatic fibrosis (HP:0100732)1.91604314
131Cerebral edema (HP:0002181)1.91280355
132Azoospermia (HP:0000027)1.91250574
133Horseshoe kidney (HP:0000085)1.91138167
134Nephroblastoma (Wilms tumor) (HP:0002667)1.91137566
135Abnormality of T cell physiology (HP:0011840)1.90368147
136Facial cleft (HP:0002006)1.89714808
137Abnormality of transition element cation homeostasis (HP:0011030)1.89536543
138Cellular immunodeficiency (HP:0005374)1.88945757
139Furrowed tongue (HP:0000221)1.86815716
140Poor head control (HP:0002421)1.86310764
141Medial flaring of the eyebrow (HP:0010747)1.85610575
142Retrobulbar optic neuritis (HP:0100654)1.85377423
143Optic neuritis (HP:0100653)1.85377423
144Abnormal rod and cone electroretinograms (HP:0008323)1.85291535
145Neoplasm of the pancreas (HP:0002894)1.84852917
146Increased nuchal translucency (HP:0010880)1.83032721
147Myositis (HP:0100614)1.82533841
148Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82378123
149Tongue fasciculations (HP:0001308)1.82224372
150Abnormality of the carotid arteries (HP:0005344)1.82183305
151Abnormality of macrophages (HP:0004311)1.82045127
152Abnormality of the metopic suture (HP:0005556)1.80956231
153Cleft eyelid (HP:0000625)1.80897037
154Inability to walk (HP:0002540)1.80793003
155Reduced antithrombin III activity (HP:0001976)1.80362165
156Impulsivity (HP:0100710)1.80209415
157Lethargy (HP:0001254)1.80137075
158Autoimmune thrombocytopenia (HP:0001973)1.80025303
159Clubbing of toes (HP:0100760)1.79189863
160Cystic liver disease (HP:0006706)1.79109886
161Postnatal microcephaly (HP:0005484)1.78178290
162Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78145467
163Exertional dyspnea (HP:0002875)1.76884541
164* Abnormality of the renal medulla (HP:0100957)1.76701776
165Ependymoma (HP:0002888)1.76062134
166Congenital hepatic fibrosis (HP:0002612)1.75400285
167Embryonal renal neoplasm (HP:0011794)1.75168146
168Abnormal spermatogenesis (HP:0008669)1.75137735
169Freckling (HP:0001480)1.75083680
170Severe muscular hypotonia (HP:0006829)1.75010073
171Methylmalonic aciduria (HP:0012120)1.74423653
172Short middle phalanx of the 5th finger (HP:0004220)1.73889377
173Abnormality of polysaccharide metabolism (HP:0011012)1.71969798
174Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71969798
175Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71969798
176Pulmonary infiltrates (HP:0002113)1.71749333
177Chronic hepatic failure (HP:0100626)1.71186060
178Neoplasm of the colon (HP:0100273)1.71134716
179Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70689277
180Loss of speech (HP:0002371)1.70575789
181Abnormality of iron homeostasis (HP:0011031)1.70282156
182Global brain atrophy (HP:0002283)1.70019930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.05402628
2FRK4.27085079
3WEE13.90466454
4ADRBK23.84586299
5MKNK13.53458256
6EIF2AK13.42147861
7CDC73.14975415
8CCNB12.81786410
9SRPK12.79516573
10MST42.76868073
11BRSK22.57148451
12STK162.27095988
13NEK12.25820595
14VRK12.23734757
15PRPF4B2.23410089
16MAP4K22.19852926
17EIF2AK32.11227741
18VRK22.08213330
19TSSK62.06380336
20NEK22.06379482
21PLK42.03137166
22GRK71.91025792
23GRK11.81447686
24PASK1.81005139
25PLK11.78742176
26IKBKB1.75137239
27PDK21.75134966
28TESK21.73026519
29BRSK11.67277927
30MKNK21.65663014
31TTK1.61303884
32PLK31.61035095
33CDK71.60513169
34CAMKK21.56961009
35AURKB1.44610033
36TAOK21.42512218
37WNK41.40040780
38TLK11.38835817
39INSRR1.38669814
40ATR1.37420136
41MATK1.35596192
42WNK31.34884948
43MAP3K141.26586215
44MAPKAPK51.23523965
45AURKA1.23490047
46NME21.17537154
47CDK81.17057405
48YES11.12679231
49SIK31.08926488
50DYRK31.07980104
51PINK11.06982469
52TESK11.06789416
53RPS6KA41.05768436
54MAPKAPK31.04885384
55MAPK151.04133234
56BLK1.03187294
57SCYL21.01822539
58ZAK0.98623481
59MAP3K120.98375240
60TBK10.95523344
61MARK30.93919979
62TGFBR20.93042885
63TGFBR10.91147921
64ACVR1B0.90974417
65CHEK20.89768403
66PAK40.88694325
67BRAF0.88032159
68OXSR10.84237106
69BTK0.83649216
70RPS6KB20.80667995
71ADRBK10.79249486
72PIM20.79125136
73RPS6KA50.79083992
74CHEK10.79007616
75EIF2AK20.77393600
76DAPK20.77320539
77AKT30.76381475
78MAP3K110.75532761
79ABL20.73662102
80CLK10.73144260
81IKBKE0.72280039
82NME10.72235649
83MAP2K30.71795297
84CSNK2A10.71503305
85BCKDK0.70707398
86MAP3K80.70145610
87TRIM280.70061640
88SYK0.68623995
89PRKCQ0.67704827
90TYK20.66925516
91DAPK10.65055133
92KIT0.64801616
93NUAK10.64051065
94MAPK130.62989262
95MUSK0.62486461
96CDK40.61506490
97KDR0.60475479
98STK40.60081796
99CDK20.58670405
100ITK0.58230765
101MAP4K10.58219331
102PBK0.57120248
103PAK10.56652407
104ZAP700.56284808
105CSNK2A20.55952536
106TEC0.55805661
107JAK30.55323218
108PTK2B0.55312717
109TNK20.54920745
110ERBB30.54878722
111DYRK20.54615621
112STK100.54122477
113FLT30.53326576
114PRKCG0.52245278
115FGR0.50427883
116CDK10.48674529
117PRKCI0.48607435
118PIM10.48587608
119IRAK40.45821407
120IRAK10.45678342
121MAP2K60.45592908
122ILK0.44623880
123LCK0.43586407
124ATM0.42967850
125TAOK30.41333199
126CSNK1A1L0.40538214
127PIK3CA0.40208357
128CAMK1D0.39949814
129CSK0.39105340
130STK390.37936968
131CSNK1G30.37930934
132NEK90.37747657
133ABL10.37388453
134CSF1R0.37008062
135LYN0.36032361
136EPHA20.35247936
137TAF10.35004066
138PRKCE0.32329432
139MYLK0.32302290
140STK30.32258863
141RPS6KL10.32205874
142RPS6KC10.32205874
143TNIK0.31959712
144TXK0.31157509
145STK240.30711242
146MAPKAPK20.30630446
147IRAK30.30263463
148BMPR1B0.30031912
149MAP3K130.29838720
150RPS6KA60.28831625
151PRKAA20.28568979
152CHUK0.27391837
153LIMK10.26661824

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.08660816
2Mismatch repair_Homo sapiens_hsa034304.23663278
3Proteasome_Homo sapiens_hsa030504.05397467
4Ribosome_Homo sapiens_hsa030103.53571907
5RNA polymerase_Homo sapiens_hsa030203.36093614
6Spliceosome_Homo sapiens_hsa030403.33486189
7Homologous recombination_Homo sapiens_hsa034403.30744597
8Base excision repair_Homo sapiens_hsa034103.30339458
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.16288681
10Nucleotide excision repair_Homo sapiens_hsa034203.15072389
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79940693
12RNA transport_Homo sapiens_hsa030132.78998287
13Pyrimidine metabolism_Homo sapiens_hsa002402.65265862
14Cell cycle_Homo sapiens_hsa041102.52368269
15Fanconi anemia pathway_Homo sapiens_hsa034602.20526196
16Basal transcription factors_Homo sapiens_hsa030222.18408633
17RNA degradation_Homo sapiens_hsa030182.11369346
18One carbon pool by folate_Homo sapiens_hsa006702.03619928
19Rheumatoid arthritis_Homo sapiens_hsa053232.02341200
20Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.01025955
21Allograft rejection_Homo sapiens_hsa053301.99601976
22Lysosome_Homo sapiens_hsa041421.95245218
23Non-homologous end-joining_Homo sapiens_hsa034501.86837045
24Graft-versus-host disease_Homo sapiens_hsa053321.82785293
25Protein export_Homo sapiens_hsa030601.82231063
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.69474504
27Autoimmune thyroid disease_Homo sapiens_hsa053201.68726702
28Collecting duct acid secretion_Homo sapiens_hsa049661.58756566
29Tryptophan metabolism_Homo sapiens_hsa003801.55760800
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55339216
31Purine metabolism_Homo sapiens_hsa002301.54592504
32Selenocompound metabolism_Homo sapiens_hsa004501.51187983
33Sulfur metabolism_Homo sapiens_hsa009201.45928091
34Butanoate metabolism_Homo sapiens_hsa006501.38924847
35Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.38770012
36p53 signaling pathway_Homo sapiens_hsa041151.35420553
37mRNA surveillance pathway_Homo sapiens_hsa030151.35038243
38Linoleic acid metabolism_Homo sapiens_hsa005911.26195727
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.25252278
40Staphylococcus aureus infection_Homo sapiens_hsa051501.24612053
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22022354
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.21260582
43Mineral absorption_Homo sapiens_hsa049781.21242208
44Epstein-Barr virus infection_Homo sapiens_hsa051691.19208049
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18083758
46alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16927700
47Parkinsons disease_Homo sapiens_hsa050121.16357920
48Huntingtons disease_Homo sapiens_hsa050161.06768621
49Ether lipid metabolism_Homo sapiens_hsa005651.04215016
50Antigen processing and presentation_Homo sapiens_hsa046121.00968066
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.00556631
52Oxidative phosphorylation_Homo sapiens_hsa001900.94663047
53N-Glycan biosynthesis_Homo sapiens_hsa005100.88267905
54Caffeine metabolism_Homo sapiens_hsa002320.87796511
55Nitrogen metabolism_Homo sapiens_hsa009100.87438171
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86803074
57Peroxisome_Homo sapiens_hsa041460.86491919
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86050270
59Chemical carcinogenesis_Homo sapiens_hsa052040.84172235
60Oocyte meiosis_Homo sapiens_hsa041140.81020983
61Phototransduction_Homo sapiens_hsa047440.79762499
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.78461868
63Herpes simplex infection_Homo sapiens_hsa051680.78136763
64TNF signaling pathway_Homo sapiens_hsa046680.76232110
65Viral carcinogenesis_Homo sapiens_hsa052030.74901108
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74025191
67Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.71588621
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71572379
69Folate biosynthesis_Homo sapiens_hsa007900.70069398
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69404534
71Systemic lupus erythematosus_Homo sapiens_hsa053220.69060977
72Thyroid cancer_Homo sapiens_hsa052160.68708531
73Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.67701975
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.66277425
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.66207592
76Primary immunodeficiency_Homo sapiens_hsa053400.64669476
77Osteoclast differentiation_Homo sapiens_hsa043800.64665808
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63953516
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63773355
80HTLV-I infection_Homo sapiens_hsa051660.63649003
81Pentose phosphate pathway_Homo sapiens_hsa000300.63205403
82Regulation of autophagy_Homo sapiens_hsa041400.62662118
83Tuberculosis_Homo sapiens_hsa051520.61417433
84Vitamin digestion and absorption_Homo sapiens_hsa049770.60949722
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60934468
86Leishmaniasis_Homo sapiens_hsa051400.60739959
87Shigellosis_Homo sapiens_hsa051310.60535020
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.58237829
89Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57660143
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.56283185
91Legionellosis_Homo sapiens_hsa051340.55665290
92Galactose metabolism_Homo sapiens_hsa000520.55318062
93Sphingolipid metabolism_Homo sapiens_hsa006000.54394424
94Biosynthesis of amino acids_Homo sapiens_hsa012300.51114395
95Phagosome_Homo sapiens_hsa041450.51092940
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50936470
97Alcoholism_Homo sapiens_hsa050340.48041774
98Maturity onset diabetes of the young_Homo sapiens_hsa049500.47636093
99Malaria_Homo sapiens_hsa051440.46830151
100Pertussis_Homo sapiens_hsa051330.46406710
101Propanoate metabolism_Homo sapiens_hsa006400.46257160
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43492870
103Alzheimers disease_Homo sapiens_hsa050100.43370290
104Cardiac muscle contraction_Homo sapiens_hsa042600.42202705
105Fatty acid elongation_Homo sapiens_hsa000620.42026434
106Vitamin B6 metabolism_Homo sapiens_hsa007500.40181919
107Sulfur relay system_Homo sapiens_hsa041220.39388588
108Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37883863
109beta-Alanine metabolism_Homo sapiens_hsa004100.37756010
110ABC transporters_Homo sapiens_hsa020100.37553562
111Glutathione metabolism_Homo sapiens_hsa004800.37489173
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36659696
113Arachidonic acid metabolism_Homo sapiens_hsa005900.34419207
114Fructose and mannose metabolism_Homo sapiens_hsa000510.33907396
115Hepatitis B_Homo sapiens_hsa051610.32564363
116Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30829163
117Carbon metabolism_Homo sapiens_hsa012000.30191331
118Measles_Homo sapiens_hsa051620.28244717
119Metabolic pathways_Homo sapiens_hsa011000.26501490
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26274645
121Drug metabolism - other enzymes_Homo sapiens_hsa009830.24915006
122Apoptosis_Homo sapiens_hsa042100.21593350
123Small cell lung cancer_Homo sapiens_hsa052220.21492434
124Acute myeloid leukemia_Homo sapiens_hsa052210.20440964
125Colorectal cancer_Homo sapiens_hsa052100.19877530
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.19828814
127Hematopoietic cell lineage_Homo sapiens_hsa046400.19164147
128Other glycan degradation_Homo sapiens_hsa005110.18418530
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.16002484
1302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15534220
131Intestinal immune network for IgA production_Homo sapiens_hsa046720.15308406
132Asthma_Homo sapiens_hsa053100.14266601
133Basal cell carcinoma_Homo sapiens_hsa052170.14002725
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.13332266
135Pathways in cancer_Homo sapiens_hsa052000.11776669
136MicroRNAs in cancer_Homo sapiens_hsa052060.11464217
137Influenza A_Homo sapiens_hsa051640.11429439
138Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.09969388
139Type I diabetes mellitus_Homo sapiens_hsa049400.09591098
140TGF-beta signaling pathway_Homo sapiens_hsa043500.09191067
141Bladder cancer_Homo sapiens_hsa052190.06509234
142Chronic myeloid leukemia_Homo sapiens_hsa052200.06459939
143NOD-like receptor signaling pathway_Homo sapiens_hsa046210.06425365
144Melanoma_Homo sapiens_hsa052180.06383953
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.06160211
146NF-kappa B signaling pathway_Homo sapiens_hsa040640.06138181
147HIF-1 signaling pathway_Homo sapiens_hsa040660.05804489
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05415192
149Notch signaling pathway_Homo sapiens_hsa043300.05176848

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