TMEM139

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cellular ketone body metabolic process (GO:0046950)7.67531495
2regulation of guanylate cyclase activity (GO:0031282)7.47350617
3ketone body metabolic process (GO:1902224)6.63165636
4cellular glucuronidation (GO:0052695)6.44255193
5glucuronate metabolic process (GO:0019585)6.20599311
6uronic acid metabolic process (GO:0006063)6.20599311
7surfactant homeostasis (GO:0043129)5.83989613
8intestinal epithelial cell development (GO:0060576)5.66560957
9interferon-gamma secretion (GO:0072643)5.55036607
10vitamin transmembrane transport (GO:0035461)5.39411911
11urea cycle (GO:0000050)5.29798795
12urea metabolic process (GO:0019627)5.26458464
133-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)5.26361270
14purine ribonucleoside bisphosphate metabolic process (GO:0034035)5.26361270
15positive regulation of guanylate cyclase activity (GO:0031284)4.98761465
16pyrimidine-containing compound transmembrane transport (GO:0072531)4.97934105
17intestinal absorption (GO:0050892)4.96112911
18mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.81227702
19sulfate transmembrane transport (GO:1902358)4.78375091
20chemical homeostasis within a tissue (GO:0048875)4.77188939
21bundle of His cell to Purkinje myocyte communication (GO:0086069)4.75744934
22epoxygenase P450 pathway (GO:0019373)4.71917699
23NADH metabolic process (GO:0006734)4.71540888
24nitrogen cycle metabolic process (GO:0071941)4.63142198
25regulation of bile acid biosynthetic process (GO:0070857)4.54050195
26desmosome organization (GO:0002934)4.53764238
27regulation of cGMP biosynthetic process (GO:0030826)4.52260843
28cellular response to nitric oxide (GO:0071732)4.49385344
29flavonoid metabolic process (GO:0009812)4.47167433
30ATP synthesis coupled proton transport (GO:0015986)4.41723725
31energy coupled proton transport, down electrochemical gradient (GO:0015985)4.41723725
32sulfur compound transport (GO:0072348)4.31923809
33calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.30136394
34cellular zinc ion homeostasis (GO:0006882)4.21151888
35cellular response to oxygen radical (GO:0071450)4.01431458
36removal of superoxide radicals (GO:0019430)4.01431458
37cellular response to superoxide (GO:0071451)4.01431458
38negative regulation of T cell differentiation in thymus (GO:0033085)3.99399549
39phenylpropanoid metabolic process (GO:0009698)3.98091076
40regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)3.95409732
41sulfate transport (GO:0008272)3.91827848
42modified amino acid transport (GO:0072337)3.91529739
43intestinal cholesterol absorption (GO:0030299)3.90210515
44positive regulation of pseudopodium assembly (GO:0031274)3.86970307
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.81889473
46L-phenylalanine metabolic process (GO:0006558)3.81889473
47sulfur amino acid catabolic process (GO:0000098)3.76599251
48sulfation (GO:0051923)3.73607428
49citrulline biosynthetic process (GO:0019240)3.72984148
50regulation of cGMP metabolic process (GO:0030823)3.71704487
51glutathione derivative biosynthetic process (GO:1901687)3.71652565
52glutathione derivative metabolic process (GO:1901685)3.71652565
53Golgi transport vesicle coating (GO:0048200)3.70285888
54COPI coating of Golgi vesicle (GO:0048205)3.70285888
55receptor guanylyl cyclase signaling pathway (GO:0007168)3.68154553
56glutamine family amino acid biosynthetic process (GO:0009084)3.68005389
57hormone catabolic process (GO:0042447)3.65633883
58phosphate ion transmembrane transport (GO:0035435)3.64247292
59positive regulation of cellular amine metabolic process (GO:0033240)3.63025724
60protein retention in ER lumen (GO:0006621)3.59698295
61vitamin transport (GO:0051180)3.59251189
62fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.59120304
63drug transmembrane transport (GO:0006855)3.58023728
64cGMP-mediated signaling (GO:0019934)3.57842814
65polyketide metabolic process (GO:0030638)3.50007838
66doxorubicin metabolic process (GO:0044598)3.50007838
67daunorubicin metabolic process (GO:0044597)3.50007838
68very-low-density lipoprotein particle assembly (GO:0034379)3.47969019
69maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.46962390
70phosphate ion transport (GO:0006817)3.46681000
71drug transport (GO:0015893)3.43541989
72negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.40564299
73citrulline metabolic process (GO:0000052)3.39451324
74regulation of protein activation cascade (GO:2000257)3.38439695
75regulation of pseudopodium assembly (GO:0031272)3.38354299
76renal absorption (GO:0070293)3.37873852
77carnitine metabolic process (GO:0009437)3.37528033
78drug catabolic process (GO:0042737)3.37037696
79negative regulation of cholesterol transport (GO:0032375)3.36310616
80negative regulation of sterol transport (GO:0032372)3.36310616
81aminoglycoside antibiotic metabolic process (GO:0030647)3.33707150
82bicarbonate transport (GO:0015701)3.32117522
83response to nitric oxide (GO:0071731)3.31081418
84arginine metabolic process (GO:0006525)3.30370125
85renal system process involved in regulation of blood volume (GO:0001977)3.25960344
86regulation of complement activation (GO:0030449)3.22055114
87primary alcohol catabolic process (GO:0034310)3.19075871
88folic acid transport (GO:0015884)3.18919058
89amino-acid betaine metabolic process (GO:0006577)3.18251380
90glutathione metabolic process (GO:0006749)3.18116577
91cellular response to reactive nitrogen species (GO:1902170)3.17635849
92multicellular organismal water homeostasis (GO:0050891)3.17246666
93positive regulation of T cell differentiation in thymus (GO:0033089)3.17101315
94gap junction assembly (GO:0016264)3.17048533
95bile acid metabolic process (GO:0008206)3.16796013
96urate metabolic process (GO:0046415)3.15829978
97actin filament depolymerization (GO:0030042)3.15800731
98regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.15684393
99regulation of chemokine secretion (GO:0090196)3.15177247
100antibacterial humoral response (GO:0019731)3.12642884
101angiotensin maturation (GO:0002003)3.11503369
102zinc ion homeostasis (GO:0055069)3.10852553
103regulation of cholesterol homeostasis (GO:2000188)3.09825221
104erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.09785030
105L-phenylalanine catabolic process (GO:0006559)3.09785030
106negative regulation of complement activation (GO:0045916)3.08236040
107proline metabolic process (GO:0006560)3.05852385
108thrombin receptor signaling pathway (GO:0070493)3.04395026
109response to superoxide (GO:0000303)3.03838765
110regulation of cholesterol esterification (GO:0010872)3.03480960
111nucleotide-sugar biosynthetic process (GO:0009226)3.02778521
112antimicrobial humoral response (GO:0019730)3.02356812
113negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.01099558
114epithelial cell-cell adhesion (GO:0090136)3.01099415
115transcytosis (GO:0045056)2.99824627
116negative regulation of protein activation cascade (GO:2000258)2.98185787
117bile acid and bile salt transport (GO:0015721)2.97525441
118regulation of apoptotic process involved in morphogenesis (GO:1902337)2.97280944
119glutathione biosynthetic process (GO:0006750)2.96789925
120GDP-mannose metabolic process (GO:0019673)2.96737642
121fat-soluble vitamin biosynthetic process (GO:0042362)2.96619316
122response to growth hormone (GO:0060416)2.96341825
123positive regulation of Cdc42 GTPase activity (GO:0043089)2.95934161
124ethanol metabolic process (GO:0006067)2.94995254
125keratinocyte development (GO:0003334)2.94958104
126diacylglycerol metabolic process (GO:0046339)2.91015032
127cytidine deamination (GO:0009972)2.89848413
128cytidine metabolic process (GO:0046087)2.89848413
129cytidine catabolic process (GO:0006216)2.89848413
130chondrocyte proliferation (GO:0035988)2.89401853
131nonribosomal peptide biosynthetic process (GO:0019184)2.89311849
132glyoxylate metabolic process (GO:0046487)2.89190557
133positive regulation of cGMP biosynthetic process (GO:0030828)2.88673709
134fructose metabolic process (GO:0006000)2.88175649
135amyloid precursor protein metabolic process (GO:0042982)2.88084088
136cellular response to leptin stimulus (GO:0044320)2.87891931
137regulation of cholesterol metabolic process (GO:0090181)2.86294798
138negative regulation of keratinocyte proliferation (GO:0010839)2.84832197
139response to oxygen radical (GO:0000305)2.84204619
140ethanol oxidation (GO:0006069)2.83322081
141homocysteine metabolic process (GO:0050667)2.83258405
142peptide catabolic process (GO:0043171)2.83148077
143positive regulation of actin filament depolymerization (GO:0030836)2.83117639
144UDP-N-acetylglucosamine metabolic process (GO:0006047)2.82155739
145ATP biosynthetic process (GO:0006754)2.80904342
146plasma lipoprotein particle assembly (GO:0034377)2.80769710
147hepatocyte apoptotic process (GO:0097284)2.80387684
148nucleoside diphosphate biosynthetic process (GO:0009133)2.80024340
149regulation of water loss via skin (GO:0033561)2.79574175
150midgut development (GO:0007494)2.78730326
151positive regulation of lipoprotein lipase activity (GO:0051006)2.75707678
152positive regulation of triglyceride lipase activity (GO:0061365)2.75707678
153very long-chain fatty acid metabolic process (GO:0000038)2.74846975
154negative regulation of lipase activity (GO:0060192)2.74162170
155water homeostasis (GO:0030104)2.73750344
156proline biosynthetic process (GO:0006561)2.73191604
157regulation of triglyceride catabolic process (GO:0010896)2.72333469
158hemidesmosome assembly (GO:0031581)2.72253295
159drug metabolic process (GO:0017144)2.71527716
160phospholipid efflux (GO:0033700)2.71310918
161renal system process involved in regulation of systemic arterial blood pressure (GO:0003071)2.70918668
162glycoside metabolic process (GO:0016137)2.69975533
163complement activation, classical pathway (GO:0006958)2.69705633
164endocrine process (GO:0050886)2.67197849
165regulation of systemic arterial blood pressure by hormone (GO:0001990)2.67197849
166regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)2.67197849
167sexual reproduction (GO:0019953)2.66361981
168glycosphingolipid catabolic process (GO:0046479)2.65304401
169establishment of skin barrier (GO:0061436)2.64917236
170protein autoprocessing (GO:0016540)2.63434037
171regulation of cholesterol biosynthetic process (GO:0045540)2.62721484
172lipoprotein metabolic process (GO:0042157)2.61652213

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human8.16630051
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse4.70935155
3SOX2_27498859_Chip-Seq_STOMACH_Mouse3.39822873
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.35632021
5CDX2_20551321_ChIP-Seq_CACO-2_Human3.33672749
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.17719781
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.07701899
8ESR2_21235772_ChIP-Seq_MCF-7_Human3.00801030
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.00215548
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.97786714
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.92679050
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.91261731
13GATA4_25053715_ChIP-Seq_YYC3_Human2.64463748
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.48581271
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.48570475
16NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.47967362
17STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.45367189
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.43696138
19LXR_22158963_ChIP-Seq_LIVER_Mouse2.21715071
20GATA6_25053715_ChIP-Seq_YYC3_Human2.20665287
21SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.20411800
22NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.17634887
23* SOX2_20726797_ChIP-Seq_SW620_Human2.10291363
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95061987
25FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.92803977
26FOXO3_23340844_ChIP-Seq_DLD1_Human1.92649370
27CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.91481817
28* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89520359
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86932753
30CLOCK_20551151_ChIP-Seq_293T_Human1.86092700
31AR_21909140_ChIP-Seq_LNCAP_Human1.78720454
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77480389
33FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.76085066
34RACK7_27058665_Chip-Seq_MCF-7_Human1.72284073
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.69886304
36ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.67447922
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.62918960
38ESR1_20079471_ChIP-ChIP_T-47D_Human1.57649539
39BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.56463531
40ZNF263_19887448_ChIP-Seq_K562_Human1.55822507
41ATF3_27146783_Chip-Seq_COLON_Human1.55433917
42KLF5_25053715_ChIP-Seq_YYC3_Human1.53400628
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52021611
44KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51391560
45ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.48934814
46RUNX1_27514584_Chip-Seq_MCF-7_Human1.48080151
47GATA3_24758297_ChIP-Seq_MCF-7_Human1.47603835
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.45306304
49NANOG_18692474_ChIP-Seq_MEFs_Mouse1.41726462
50RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41121909
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.39073261
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.39073261
53P63_26484246_Chip-Seq_KERATINOCYTES_Human1.37236390
54ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.34602829
55TCF3_18692474_ChIP-Seq_MEFs_Mouse1.33491042
56SMC4_20622854_ChIP-Seq_HELA_Human1.33361692
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.32329432
58CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31538880
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.31347050
60NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31067002
61ELF5_23300383_ChIP-Seq_T47D_Human1.29726034
62ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27689296
63SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26417406
64OCT4_18692474_ChIP-Seq_MEFs_Mouse1.24072479
65EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.23124583
66PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.22611505
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20938567
68POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.20891919
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19394495
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19166182
71E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.16945628
72* HNF4A_19822575_ChIP-Seq_HepG2_Human1.15995572
73CTCF_27219007_Chip-Seq_Bcells_Human1.14542160
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13350727
75SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.13035398
76ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12786976
77FOXA2_19822575_ChIP-Seq_HepG2_Human1.09396396
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08996141
79TP63_22573176_ChIP-Seq_HFKS_Human1.07882784
80ELK3_25401928_ChIP-Seq_HUVEC_Human1.07391131
81SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05494846
82CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.04860128
83LXR_22292898_ChIP-Seq_THP-1_Human1.02899089
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01391652
85SOX9_24532713_ChIP-Seq_HFSC_Mouse1.01158118
86TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.01051003
87NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.00568892
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00536378
89FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.97910741
90EGR1_19032775_ChIP-ChIP_M12_Human0.97433629
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96432364
92BCOR_27268052_Chip-Seq_Bcells_Human0.96226242
93AHR_22903824_ChIP-Seq_MCF-7_Human0.96010318
94ERG_21242973_ChIP-ChIP_JURKAT_Human0.95767441
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94607521
96P68_20966046_ChIP-Seq_HELA_Human0.93973478
97TCF4_18268006_ChIP-ChIP_LS174T_Human0.93197840
98HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91802422
99UBF1/2_26484160_Chip-Seq_HMECs_Human0.91800446
100FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88811656
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88225032
102SA1_27219007_Chip-Seq_ERYTHROID_Human0.87430980
103CSB_26484114_Chip-Seq_FIBROBLAST_Human0.86967321
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86808281
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86808281
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86808281
107SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85721143
108SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85533170
109CHD1_26751641_Chip-Seq_LNCaP_Human0.85438147
110CREB1_26743006_Chip-Seq_LNCaP_Human0.84878525
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82678505
112ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.81479563
113PHF8_20622854_ChIP-Seq_HELA_Human0.81092954
114RARA_24833708_ChIP-Seq_LIVER_Mouse0.81034009
115AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.80422817
116SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.79552075
117FOXA1_25552417_ChIP-Seq_VCAP_Human0.78615343
118ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78576731
119PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.78159790
120CTCF_20526341_ChIP-Seq_ESCs_Human0.77375294
121RXR_22108803_ChIP-Seq_LS180_Human0.77186528
122SA1_27219007_Chip-Seq_Bcells_Human0.77044785
123* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76834251
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.75368092
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.74868260
126IKZF1_21737484_ChIP-ChIP_HCT116_Human0.74757865
127GATA2_21666600_ChIP-Seq_HMVEC_Human0.72478102
128JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.72303786
129UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.72235911
130POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.71970395
131TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71698382

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.77517041
2MP0003878_abnormal_ear_physiology5.77517041
3MP0003283_abnormal_digestive_organ4.38323374
4MP0005360_urolithiasis4.30601346
5MP0002822_catalepsy4.11930002
6MP0008875_abnormal_xenobiotic_pharmacok3.87671630
7MP0001666_abnormal_nutrient_absorption3.51576948
8MP0004019_abnormal_vitamin_homeostasis3.18495249
9MP0004043_abnormal_pH_regulation3.08733135
10MP0002139_abnormal_hepatobiliary_system3.03634443
11MP0003941_abnormal_skin_development3.02472068
12MP0005085_abnormal_gallbladder_physiolo3.01650833
13MP0010234_abnormal_vibrissa_follicle3.01238253
14MP0009840_abnormal_foam_cell2.62971727
15MP0005084_abnormal_gallbladder_morpholo2.48267101
16MP0000462_abnormal_digestive_system2.41172436
17MP0002796_impaired_skin_barrier2.40600927
18MP0003191_abnormal_cellular_cholesterol2.28005902
19MP0003806_abnormal_nucleotide_metabolis2.27061605
20MP0003183_abnormal_peptide_metabolism2.22549841
21MP0003868_abnormal_feces_composition2.15926742
22MP0005365_abnormal_bile_salt1.94668391
23MP0009643_abnormal_urine_homeostasis1.92612824
24MP0001765_abnormal_ion_homeostasis1.87965680
25MP0009697_abnormal_copulation1.86175383
26MP0000566_synostosis1.77988773
27MP0004264_abnormal_extraembryonic_tissu1.75426692
28MP0005083_abnormal_biliary_tract1.71719253
29MP0005636_abnormal_mineral_homeostasis1.69406006
30MP0000490_abnormal_crypts_of1.63700282
31MP0004782_abnormal_surfactant_physiolog1.61343263
32MP0002876_abnormal_thyroid_physiology1.58551348
33MP0001873_stomach_inflammation1.58054869
34MP0010352_gastrointestinal_tract_polyps1.55948638
35MP0009379_abnormal_foot_pigmentation1.54601852
36MP0001756_abnormal_urination1.51884113
37MP0005410_abnormal_fertilization1.50386529
38MP0000537_abnormal_urethra_morphology1.49880847
39MP0005332_abnormal_amino_acid1.49867267
40MP0000579_abnormal_nail_morphology1.46636901
41MP0005058_abnormal_lysosome_morphology1.46600287
42MP0002653_abnormal_ependyma_morphology1.45517151
43MP0005381_digestive/alimentary_phenotyp1.45188525
44MP0003705_abnormal_hypodermis_morpholog1.42227144
45MP0003866_abnormal_defecation1.42219283
46MP0005167_abnormal_blood-brain_barrier1.41693796
47MP0000477_abnormal_intestine_morphology1.39053591
48MP0010155_abnormal_intestine_physiology1.39015655
49MP0005501_abnormal_skin_physiology1.38299097
50MP0000762_abnormal_tongue_morphology1.34774743
51MP0005409_darkened_coat_color1.34309330
52MP0005451_abnormal_body_composition1.34048960
53MP0008004_abnormal_stomach_pH1.33403727
54MP0001663_abnormal_digestive_system1.29105501
55MP0001881_abnormal_mammary_gland1.27122482
56MP0001764_abnormal_homeostasis1.23736728
57MP0010030_abnormal_orbit_morphology1.22481146
58MP0010678_abnormal_skin_adnexa1.21998455
59MP0009384_cardiac_valve_regurgitation1.17375149
60MP0000538_abnormal_urinary_bladder1.15661996
61MP0002098_abnormal_vibrissa_morphology1.15051664
62MP0010386_abnormal_urinary_bladder1.14899889
63MP0002009_preneoplasia1.14021725
64MP0002132_abnormal_respiratory_system1.13792350
65MP0000627_abnormal_mammary_gland1.13691696
66MP0000678_abnormal_parathyroid_gland1.13511650
67MP0003186_abnormal_redox_activity1.09853235
68MP0002136_abnormal_kidney_physiology1.09378457
69MP0005248_abnormal_Harderian_gland1.06604527
70MP0001664_abnormal_digestion1.06369820
71MP0003718_maternal_effect1.05270445
72MP0010329_abnormal_lipoprotein_level1.03218223
73MP0004885_abnormal_endolymph0.98900186
74MP0002254_reproductive_system_inflammat0.97139979
75MP0002060_abnormal_skin_morphology0.96445497
76MP0001216_abnormal_epidermal_layer0.96277609
77MP0000383_abnormal_hair_follicle0.93929786
78MP0005319_abnormal_enzyme/_coenzyme0.93925403
79MP0003252_abnormal_bile_duct0.93314295
80MP0005023_abnormal_wound_healing0.93055658
81MP0004484_altered_response_of0.92406074
82MP0009780_abnormal_chondrocyte_physiolo0.92232257
83MP0003195_calcinosis0.91357254
84MP0002138_abnormal_hepatobiliary_system0.86779825
85MP0001661_extended_life_span0.84219463
86MP0002118_abnormal_lipid_homeostasis0.83794277
87MP0003638_abnormal_response/metabolism_0.83100042
88MP0004233_abnormal_muscle_weight0.80997840
89MP0000003_abnormal_adipose_tissue0.79768110
90MP0008260_abnormal_autophagy0.79124655
91MP0005166_decreased_susceptibility_to0.78914791
92MP0010368_abnormal_lymphatic_system0.77416805
93MP0008789_abnormal_olfactory_epithelium0.76219451
94MP0000427_abnormal_hair_cycle0.75100207
95MP0001849_ear_inflammation0.74750683
96MP0003879_abnormal_hair_cell0.74196528
97MP0002006_tumorigenesis0.73908440
98MP0001485_abnormal_pinna_reflex0.73751737
99MP0002896_abnormal_bone_mineralization0.71398558
100MP0002909_abnormal_adrenal_gland0.70212786
101MP0005330_cardiomyopathy0.68528638
102MP0005666_abnormal_adipose_tissue0.67501543
103MP0010771_integument_phenotype0.66825033
104MP0001346_abnormal_lacrimal_gland0.65610617
105MP0000470_abnormal_stomach_morphology0.65198382
106MP0002277_abnormal_respiratory_mucosa0.64829993
107MP0003011_delayed_dark_adaptation0.64172082
108MP0002166_altered_tumor_susceptibility0.64153358
109MP0009053_abnormal_anal_canal0.64064840
110MP0003315_abnormal_perineum_morphology0.62161857
111MP0001177_atelectasis0.61324300
112MP0003693_abnormal_embryo_hatching0.61194976
113MP0003950_abnormal_plasma_membrane0.60396074
114MP0006138_congestive_heart_failure0.59961423
115MP0005408_hypopigmentation0.59827916
116MP0000467_abnormal_esophagus_morphology0.58585333
117MP0005375_adipose_tissue_phenotype0.57497972
118MP0009931_abnormal_skin_appearance0.57340205
119MP0004947_skin_inflammation0.55278730
120MP0005584_abnormal_enzyme/coenzyme_acti0.55272343
121MP0001958_emphysema0.54614475
122MP0000609_abnormal_liver_physiology0.53111753
123MP0000377_abnormal_hair_follicle0.49869844
124MP0005395_other_phenotype0.48200233
125MP0003453_abnormal_keratinocyte_physiol0.48188586
126MP0000230_abnormal_systemic_arterial0.47901819
127MP0004272_abnormal_basement_membrane0.41659906
128MP0002234_abnormal_pharynx_morphology0.40630910
129MP0003566_abnormal_cell_adhesion0.40219235
130MP0005670_abnormal_white_adipose0.39840495

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.89871316
2Gout (HP:0001997)4.79221210
3Flat acetabular roof (HP:0003180)4.78411158
4Abnormality of the 1st metacarpal (HP:0010009)4.70237117
5Right ventricular cardiomyopathy (HP:0011663)4.27266159
6Abnormality of the distal phalanx of the thumb (HP:0009617)4.23319334
7Alopecia of scalp (HP:0002293)4.18671775
8Metabolic alkalosis (HP:0200114)4.08185814
9Hypobetalipoproteinemia (HP:0003563)4.04612218
10Pili torti (HP:0003777)3.98901245
11Ileus (HP:0002595)3.93684462
12Abnormality of carpal bone ossification (HP:0006257)3.90310240
13Deep venous thrombosis (HP:0002625)3.89213351
14Hyperactive renin-angiotensin system (HP:0000841)3.85680129
15Abnormal tarsal ossification (HP:0008369)3.72857930
16Symphalangism affecting the phalanges of the hand (HP:0009773)3.65562624
17Abnormality of the middle phalanges of the toes (HP:0010183)3.57154583
18Short phalanx of the thumb (HP:0009660)3.48165247
19Cupped ribs (HP:0000887)3.35110014
20Abnormality of the proximal phalanges of the hand (HP:0009834)3.33831964
21Vascular calcification (HP:0004934)3.28838528
22Abnormal hand bone ossification (HP:0010660)3.26057745
23Abnormality of chloride homeostasis (HP:0011422)3.23933895
24Hyperuricemia (HP:0002149)3.20652721
25Increased purine levels (HP:0004368)3.20652721
26Systemic lupus erythematosus (HP:0002725)3.19422144
27Abnormality of purine metabolism (HP:0004352)3.18227771
28Abnormal hair laboratory examination (HP:0003328)3.17077491
29Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14615006
30Intrahepatic cholestasis (HP:0001406)3.14572565
31Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)3.09246961
32Hyperammonemia (HP:0001987)3.07597239
33Cheilitis (HP:0100825)3.05842454
34Abnormal ossification of hand bones (HP:0005921)3.03865162
35Abnormality of proline metabolism (HP:0010907)2.99686434
36Hydroxyprolinuria (HP:0003080)2.99686434
37Proximal tubulopathy (HP:0000114)2.97936096
38Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.97498757
39Abnormality of the 2nd finger (HP:0004100)2.97311052
40Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.96608416
41Prolonged partial thromboplastin time (HP:0003645)2.94548621
42Abnormality of the phalanges of the hallux (HP:0010057)2.91710306
43Abnormality of glutamine family amino acid metabolism (HP:0010902)2.91362418
44Abnormal foot bone ossification (HP:0010675)2.87649124
45Focal segmental glomerulosclerosis (HP:0000097)2.87317290
46Hyperglycinuria (HP:0003108)2.86148932
47Glomerulosclerosis (HP:0000096)2.82710983
48Abdominal distention (HP:0003270)2.80293071
49Cardiovascular calcification (HP:0011915)2.75717754
50Reduced antithrombin III activity (HP:0001976)2.74942224
51Short hallux (HP:0010109)2.73957526
52Abnormality of renin-angiotensin system (HP:0000847)2.72635501
53Abnormality of the distal phalanges of the toes (HP:0010182)2.71818363
54Abnormality of pyrimidine metabolism (HP:0004353)2.67176216
55Hypolipoproteinemia (HP:0010981)2.66925592
56Renal salt wasting (HP:0000127)2.65983608
57Complement deficiency (HP:0004431)2.65978466
58Widely patent fontanelles and sutures (HP:0004492)2.65119288
59Flattened epiphyses (HP:0003071)2.57731104
60Hemorrhage of the eye (HP:0011885)2.57266288
61Aplasia/hypoplasia of the femur (HP:0005613)2.54991471
62Abnormality of dicarboxylic acid metabolism (HP:0010995)2.53762715
63Dicarboxylic aciduria (HP:0003215)2.53762715
64Aplasia/Hypoplasia of the hallux (HP:0008362)2.51981785
65Abnormality of magnesium homeostasis (HP:0004921)2.51920634
66Hypokalemic alkalosis (HP:0001949)2.51579676
67Neonatal short-limb short stature (HP:0008921)2.51565378
68Increased circulating renin level (HP:0000848)2.49517846
69Abnormality of urine glucose concentration (HP:0011016)2.49047003
70Glycosuria (HP:0003076)2.49047003
71Short middle phalanx of finger (HP:0005819)2.48183495
72Abnormality of complement system (HP:0005339)2.44522712
73Acute encephalopathy (HP:0006846)2.44260999
74Acute necrotizing encephalopathy (HP:0006965)2.43453593
75Malnutrition (HP:0004395)2.42958505
76Alkalosis (HP:0001948)2.42822448
77Hypomagnesemia (HP:0002917)2.40613534
78Abnormal vertebral ossification (HP:0100569)2.39570568
79Lethargy (HP:0001254)2.34919959
80Absent phalangeal crease (HP:0006109)2.34122782
81Conjugated hyperbilirubinemia (HP:0002908)2.33866475
82Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.33568861
83Vertebral hypoplasia (HP:0008417)2.33568861
84Onycholysis (HP:0001806)2.31961336
85Abnormal mitochondria in muscle tissue (HP:0008316)2.29682945
86Hypokinesia (HP:0002375)2.29546164
87Glomerulonephritis (HP:0000099)2.28042593
88Cerebral edema (HP:0002181)2.19466036
89Septate vagina (HP:0001153)2.19399003
90Abnormality of renal excretion (HP:0011036)2.18961340
91Abnormal cartilage morphology (HP:0002763)2.18611953
92Fragile nails (HP:0001808)2.17974805
93Hypotension (HP:0002615)2.16922073
94Congenital ichthyosiform erythroderma (HP:0007431)2.16830289
95Partial duplication of thumb phalanx (HP:0009944)2.16736933
96Generalized aminoaciduria (HP:0002909)2.15047710
97Dehydration (HP:0001944)2.14344115
98Short femoral neck (HP:0100864)2.13611399
99Abnormality of nucleobase metabolism (HP:0010932)2.13560124
100Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12060591
101Xanthomatosis (HP:0000991)2.11620726
102Hyperaldosteronism (HP:0000859)2.11210859
103Hypophosphatemia (HP:0002148)2.09924384
104Thin bony cortex (HP:0002753)2.09360064
105Abnormality of cells of the erythroid lineage (HP:0012130)2.07634161
106Renal tubular acidosis (HP:0001947)2.06069527
107Abnormality of serine family amino acid metabolism (HP:0010894)2.04712970
108Abnormality of glycine metabolism (HP:0010895)2.04712970
109Curly hair (HP:0002212)2.04240871
110Wide cranial sutures (HP:0010537)2.04217700
111Potter facies (HP:0002009)2.04049410
112Facial shape deformation (HP:0011334)2.04049410
113Polycythemia (HP:0001901)2.02940321
114Ventricular tachycardia (HP:0004756)2.02748163
115Hypoglycemic coma (HP:0001325)2.02307058
116Steatorrhea (HP:0002570)2.01798097
117Popliteal pterygium (HP:0009756)2.00868434
118Acanthosis nigricans (HP:0000956)2.00801863
119Abnormality of vitamin metabolism (HP:0100508)1.99877005
120Distal lower limb muscle weakness (HP:0009053)1.99354777
121Abnormal urine phosphate concentration (HP:0012599)1.97588342
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.97510395
123Pterygium (HP:0001059)1.96597931
124Mitral stenosis (HP:0001718)1.96475555
125Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95219722
126Decreased circulating renin level (HP:0003351)1.95036836
127Protuberant abdomen (HP:0001538)1.94929313
128Villous atrophy (HP:0011473)1.93650779
129Abnormality of small intestinal villus morphology (HP:0011472)1.93650779
130Progressive macrocephaly (HP:0004481)1.92644383
131Pigmentary retinal degeneration (HP:0001146)1.91548077
132Fat malabsorption (HP:0002630)1.90779665
133Vaginal fistula (HP:0004320)1.90352402
134Hypoplasia of dental enamel (HP:0006297)1.90236684
135Microretrognathia (HP:0000308)1.89137273
136Metabolic acidosis (HP:0001942)1.88285768
137Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.87926838
138Abnormality of alkaline phosphatase activity (HP:0004379)1.87746358
139Abnormal finger flexion creases (HP:0006143)1.87516323
140Broad metatarsal (HP:0001783)1.86295038
141Nephritis (HP:0000123)1.85425520
142Spinal cord compression (HP:0002176)1.84893501
143Abnormal pancreas size (HP:0012094)1.84689358
144Abnormality of fatty-acid metabolism (HP:0004359)1.84071423
145Woolly hair (HP:0002224)1.83652485
146Plantar hyperkeratosis (HP:0007556)1.83483086
147Partial duplication of the phalanx of hand (HP:0009999)1.83166111
148Milia (HP:0001056)1.82925939
149Amelogenesis imperfecta (HP:0000705)1.82859340
150Abnormal enzyme/coenzyme activity (HP:0012379)1.82191624
151Hypokalemia (HP:0002900)1.81926190
152Abnormality of the vitamin B12 metabolism (HP:0004341)1.81886011
153Coxa vara (HP:0002812)1.80645213
154Hyperphosphaturia (HP:0003109)1.80335958
155Nephrolithiasis (HP:0000787)1.78987569
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78472756
157Bone pain (HP:0002653)1.78024711
158Confusion (HP:0001289)1.77917109
159Abnormality of sulfur amino acid metabolism (HP:0004339)1.77859426
160Short nail (HP:0001799)1.77149230
161Rickets (HP:0002748)1.76018858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R7.09810543
2PIK3CA4.93979961
3EPHA24.30605689
4MST43.80788931
5FRK3.06114242
6WNK42.94735890
7MAP3K32.74084928
8MET2.56284552
9MAP2K22.52049698
10AKT32.31866717
11EPHB21.95489361
12BCKDK1.93207985
13LMTK21.92745645
14MAP3K21.91220960
15PRKG21.85521846
16TESK11.84822955
17RIPK11.82198931
18STK391.79041612
19SIK11.78068560
20NME21.74632116
21OXSR11.74316091
22GRK61.71139935
23MAP3K121.68891776
24PBK1.68413206
25LATS21.67807514
26MAP3K111.65450656
27TAOK11.59780808
28LRRK21.50572561
29FGFR41.49982279
30TRIB31.44699117
31CDK121.41899702
32CDK31.41603820
33RPS6KB21.38931955
34PRKCI1.38821201
35EIF2AK11.29015395
36WNK31.26497214
37ICK1.24397747
38BRAF1.22459954
39NME11.21297613
40TESK21.20804783
41NEK11.19673083
42STK381.15969348
43PINK11.04035084
44PAK31.03952683
45CAMK2D1.02434677
46MAPKAPK31.01348476
47DDR20.98496926
48PAK40.98402274
49ACVR1B0.88931823
50PIM20.85075830
51MAP2K10.82019650
52MAPKAPK50.77707854
53MAP3K80.76602763
54MYLK0.73630689
55NEK60.73310046
56PDGFRA0.73178186
57SMG10.72856317
58CAMK1D0.72321436
59FER0.70684912
60ILK0.69115515
61TAOK20.68254409
62MATK0.67507000
63STK100.67410998
64NTRK10.64584908
65CDK70.60146316
66FGFR20.59461661
67STK38L0.59016366
68EPHB10.58943434
69PDK30.58333584
70PDK40.58333584
71DMPK0.57366340
72MAP2K60.55566213
73SGK4940.54058269
74SGK2230.54058269
75ZAP700.53017412
76LIMK10.53003330
77CDK80.52846621
78MAP2K30.51627111
79MUSK0.50823016
80PKN20.50814076
81PDK20.50477552
82AURKB0.49220571
83CAMK2B0.47710543
84PTK60.46055351
85CDC42BPA0.43733367
86GSK3A0.43320602
87PAK10.43125095
88ERBB20.43119873
89CAMK2G0.42413593
90MTOR0.42100432
91PRKCA0.41085885
92MAP3K10.41008010
93ABL20.40859802
94MAP3K100.40681960
95ERN10.40067833
96ADRBK10.39847639
97KDR0.39055899
98DAPK10.37410526
99PRKAA20.37129773
100CAMK10.37077636
101LATS10.36854603
102PTK20.36702062
103ARAF0.36407308
104MAPK150.35791388
105EPHA30.35493976
106SCYL20.35409251
107RET0.35200158
108TTK0.32521844
109ROCK10.29682628
110MAP3K90.29568887
111IRAK30.29396096
112NLK0.29092544
113CDK60.28735147
114MAPKAPK20.28669483
115AKT20.28567950
116SGK30.28228986
117CDK11A0.27960635
118DAPK30.27943828
119CSK0.27706933
120CDK150.27127415
121ERBB40.27104563
122STK240.26077774
123CSNK1A10.25520782
124MAPK110.25406098
125SRC0.25392239
126WNK10.25123794
127KSR20.24403614
128PDGFRB0.23594977
129PRKCD0.23320688
130CDK180.21397865
131GRK10.21376139
132NEK90.20667463
133SGK20.19834524
134NEK20.19636597
135SIK30.19351850
136BMX0.19124250
137PDPK10.18185509
138CDK90.17706504
139PRKCE0.15786539
140IRAK20.14766182

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009205.85202016
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000724.61091646
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.41083895
4Pentose and glucuronate interconversions_Homo sapiens_hsa000403.01628530
5Mineral absorption_Homo sapiens_hsa049782.82812915
6Sulfur relay system_Homo sapiens_hsa041222.59588512
7Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.56507983
8Butanoate metabolism_Homo sapiens_hsa006502.54831913
9Fat digestion and absorption_Homo sapiens_hsa049752.54821449
10Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.26603870
11Chemical carcinogenesis_Homo sapiens_hsa052041.99478624
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.97740746
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.94593234
14Histidine metabolism_Homo sapiens_hsa003401.93578694
15Oxidative phosphorylation_Homo sapiens_hsa001901.88462016
16Folate biosynthesis_Homo sapiens_hsa007901.87707159
17Starch and sucrose metabolism_Homo sapiens_hsa005001.87259746
18Glutathione metabolism_Homo sapiens_hsa004801.78276381
19Vitamin digestion and absorption_Homo sapiens_hsa049771.76744377
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.69275609
21Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.60511674
22Fructose and mannose metabolism_Homo sapiens_hsa000511.59986715
23Complement and coagulation cascades_Homo sapiens_hsa046101.58588795
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55650969
25Galactose metabolism_Homo sapiens_hsa000521.51998530
26Retinol metabolism_Homo sapiens_hsa008301.42274787
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40164207
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.39609791
29Parkinsons disease_Homo sapiens_hsa050121.37757809
30Renin-angiotensin system_Homo sapiens_hsa046141.37225152
31Tryptophan metabolism_Homo sapiens_hsa003801.34623122
32Fatty acid degradation_Homo sapiens_hsa000711.31665582
33Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30886150
34Bile secretion_Homo sapiens_hsa049761.27892652
35Cyanoamino acid metabolism_Homo sapiens_hsa004601.27779753
36Linoleic acid metabolism_Homo sapiens_hsa005911.26359971
37PPAR signaling pathway_Homo sapiens_hsa033201.20738896
38Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.19796545
39Caffeine metabolism_Homo sapiens_hsa002321.17902547
40Alzheimers disease_Homo sapiens_hsa050101.17103591
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.10421195
42Phenylalanine metabolism_Homo sapiens_hsa003601.09970374
43Arachidonic acid metabolism_Homo sapiens_hsa005901.08276272
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05008766
45beta-Alanine metabolism_Homo sapiens_hsa004100.99952628
46Protein digestion and absorption_Homo sapiens_hsa049740.97257886
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.93326339
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92595669
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.91180241
50Arginine and proline metabolism_Homo sapiens_hsa003300.90809345
51Propanoate metabolism_Homo sapiens_hsa006400.90238294
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87947806
53Huntingtons disease_Homo sapiens_hsa050160.83479224
54Carbon metabolism_Homo sapiens_hsa012000.81111023
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.78397720
56Pentose phosphate pathway_Homo sapiens_hsa000300.77795248
57Tight junction_Homo sapiens_hsa045300.77107962
58Glycerolipid metabolism_Homo sapiens_hsa005610.74665634
59Pancreatic secretion_Homo sapiens_hsa049720.74653678
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.73664251
61Fatty acid biosynthesis_Homo sapiens_hsa000610.73276912
62Cardiac muscle contraction_Homo sapiens_hsa042600.72995067
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.72669207
64Fatty acid metabolism_Homo sapiens_hsa012120.72479132
65N-Glycan biosynthesis_Homo sapiens_hsa005100.71923951
66African trypanosomiasis_Homo sapiens_hsa051430.71586133
67Peroxisome_Homo sapiens_hsa041460.69877106
68Pyruvate metabolism_Homo sapiens_hsa006200.69044377
69Ribosome_Homo sapiens_hsa030100.66958710
70Nitrogen metabolism_Homo sapiens_hsa009100.66821084
71Sphingolipid metabolism_Homo sapiens_hsa006000.63690050
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61080675
73Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60502107
74Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58776759
75Vitamin B6 metabolism_Homo sapiens_hsa007500.57584868
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56655283
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55668831
78Metabolic pathways_Homo sapiens_hsa011000.50897213
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50506304
80Steroid biosynthesis_Homo sapiens_hsa001000.47928984
81Ether lipid metabolism_Homo sapiens_hsa005650.47606484
82Proteasome_Homo sapiens_hsa030500.45607533
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44514482
84Thyroid cancer_Homo sapiens_hsa052160.43850849
85ABC transporters_Homo sapiens_hsa020100.40350532
86Tyrosine metabolism_Homo sapiens_hsa003500.39602511
87Adherens junction_Homo sapiens_hsa045200.38890839
88Bladder cancer_Homo sapiens_hsa052190.38677068
89Primary bile acid biosynthesis_Homo sapiens_hsa001200.37665374
90Glycerophospholipid metabolism_Homo sapiens_hsa005640.37233723
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35918058
92Other glycan degradation_Homo sapiens_hsa005110.33609710
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33211596
94Arginine biosynthesis_Homo sapiens_hsa002200.33176278
95Hedgehog signaling pathway_Homo sapiens_hsa043400.31989296
96Vibrio cholerae infection_Homo sapiens_hsa051100.31958022
97Fatty acid elongation_Homo sapiens_hsa000620.31450627
98Gastric acid secretion_Homo sapiens_hsa049710.30529343
99Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.30219087
100Insulin resistance_Homo sapiens_hsa049310.29565018
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.28099176
102Glucagon signaling pathway_Homo sapiens_hsa049220.27961299
103Salivary secretion_Homo sapiens_hsa049700.27930007
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24462914
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.24138532
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23972435
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.22000866
108Hepatitis C_Homo sapiens_hsa051600.20193044
109Thyroid hormone synthesis_Homo sapiens_hsa049180.19683591
110Selenocompound metabolism_Homo sapiens_hsa004500.16366808
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.15369633
112Salmonella infection_Homo sapiens_hsa051320.15358093
113Central carbon metabolism in cancer_Homo sapiens_hsa052300.15158439
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15147194
115AMPK signaling pathway_Homo sapiens_hsa041520.14824736
116Biosynthesis of amino acids_Homo sapiens_hsa012300.13799157
117ECM-receptor interaction_Homo sapiens_hsa045120.11831268
118Lysine degradation_Homo sapiens_hsa003100.09378789

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