TMEM140

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)5.05037983
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05037983
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84254487
4positive regulation of gamma-delta T cell activation (GO:0046645)4.67782111
5antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41163050
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41163050
7neutrophil activation (GO:0042119)4.14117182
8low-density lipoprotein particle clearance (GO:0034383)3.97583096
9antigen processing and presentation of endogenous antigen (GO:0019883)3.96841740
10regulation of B cell receptor signaling pathway (GO:0050855)3.94695343
11granulocyte activation (GO:0036230)3.92786858
12detection of other organism (GO:0098543)3.89003826
13leukocyte migration involved in inflammatory response (GO:0002523)3.88884685
14positive regulation of interferon-alpha production (GO:0032727)3.78566858
15detection of bacterium (GO:0016045)3.70674554
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.66340650
17regulation of cholesterol storage (GO:0010885)3.66210996
18regulation of interferon-alpha production (GO:0032647)3.58238505
19negative regulation of interleukin-12 production (GO:0032695)3.57739260
20positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.53504079
21response to type I interferon (GO:0034340)3.48219080
22cellular response to type I interferon (GO:0071357)3.46566890
23type I interferon signaling pathway (GO:0060337)3.46566890
24regulation of gamma-delta T cell activation (GO:0046643)3.45564577
25detection of external biotic stimulus (GO:0098581)3.44208677
26regulation of interferon-beta biosynthetic process (GO:0045357)3.39546677
27microglial cell activation (GO:0001774)3.39380227
28regulation of platelet aggregation (GO:0090330)3.38127502
29myeloid cell activation involved in immune response (GO:0002275)3.34856367
30cellular extravasation (GO:0045123)3.28808278
31positive regulation of mast cell activation (GO:0033005)3.27373522
32negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.25075940
33response to interferon-alpha (GO:0035455)3.24436612
34neutrophil activation involved in immune response (GO:0002283)3.24177543
35positive regulation by symbiont of host defense response (GO:0052509)3.22905329
36modulation by symbiont of host defense response (GO:0052031)3.22905329
37modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.22905329
38modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.22905329
39positive regulation by organism of defense response of other organism involved in symbiotic interact3.22905329
40modulation by symbiont of host immune response (GO:0052553)3.22905329
41regulation of mast cell degranulation (GO:0043304)3.22242139
42plasma lipoprotein particle clearance (GO:0034381)3.20472974
43protein carboxylation (GO:0018214)3.19774490
44peptidyl-glutamic acid carboxylation (GO:0017187)3.19774490
45negative regulation of lymphocyte mediated immunity (GO:0002707)3.17647612
46valine metabolic process (GO:0006573)3.17112697
47response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.16726878
48response to host immune response (GO:0052572)3.16726878
49immunoglobulin mediated immune response (GO:0016064)3.15427490
50hydrogen peroxide biosynthetic process (GO:0050665)3.14400838
51daunorubicin metabolic process (GO:0044597)3.12577641
52polyketide metabolic process (GO:0030638)3.12577641
53doxorubicin metabolic process (GO:0044598)3.12577641
54response to interleukin-15 (GO:0070672)3.08984986
55negative regulation of T-helper cell differentiation (GO:0045623)3.08017071
56negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08017071
57regulation of T-helper 2 cell differentiation (GO:0045628)3.06052931
58dendritic cell chemotaxis (GO:0002407)3.05210803
59regulation of regulatory T cell differentiation (GO:0045589)3.04888951
60germinal center formation (GO:0002467)3.03529927
61regulation of platelet activation (GO:0010543)3.03307049
62complement activation, alternative pathway (GO:0006957)3.00693780
63fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99412157
64regulation of mast cell activation involved in immune response (GO:0033006)2.97586922
65negative regulation of lipid storage (GO:0010888)2.97427476
66regulation of gamma-delta T cell differentiation (GO:0045586)2.96906404
67leukocyte degranulation (GO:0043299)2.96439991
68negative regulation of leukocyte mediated immunity (GO:0002704)2.95679036
69positive regulation of type 2 immune response (GO:0002830)2.94013903
70detection of biotic stimulus (GO:0009595)2.93956673
71macrophage activation (GO:0042116)2.93848145
72macrophage activation involved in immune response (GO:0002281)2.92171962
73triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.91888837
74phagocytosis, recognition (GO:0006910)2.91746037
75regulation of mast cell activation (GO:0033003)2.89969135
76sulfur amino acid catabolic process (GO:0000098)2.89426336
77response to host (GO:0075136)2.88051165
78response to host defenses (GO:0052200)2.88051165
79response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.88051165
80regulation of sequestering of triglyceride (GO:0010889)2.87181701
81leukocyte aggregation (GO:0070486)2.87109599
82regulation of T-helper 1 cell differentiation (GO:0045625)2.85397976
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.85073988
84regulation of natural killer cell mediated immunity (GO:0002715)2.85073988
85positive regulation of cellular amide metabolic process (GO:0034250)2.84868438
86regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84446055
87positive regulation of B cell differentiation (GO:0045579)2.82748785
88positive regulation of toll-like receptor signaling pathway (GO:0034123)2.81479763
89response to peptidoglycan (GO:0032494)2.80905182
90regulation of T cell tolerance induction (GO:0002664)2.79333645
91dendritic cell migration (GO:0036336)2.77201155
92regulation of T cell mediated cytotoxicity (GO:0001914)2.76485697
93positive regulation of macrophage differentiation (GO:0045651)2.75643086
94cellular response to interleukin-15 (GO:0071350)2.74988180
95negative regulation of T cell mediated immunity (GO:0002710)2.74924032
96reactive oxygen species biosynthetic process (GO:1903409)2.74301027
97negative regulation of cytokine production involved in immune response (GO:0002719)2.74085959
98regulation of protein activation cascade (GO:2000257)2.72885920
99positive regulation of T cell mediated cytotoxicity (GO:0001916)2.72508280
100regulation of leukocyte degranulation (GO:0043300)2.71862845
101negative regulation of innate immune response (GO:0045824)2.71529507
102thrombin receptor signaling pathway (GO:0070493)2.70952683
103defense response to protozoan (GO:0042832)2.70103386
104B cell receptor signaling pathway (GO:0050853)2.69988199
105regulation of complement activation (GO:0030449)2.68748410
106T cell migration (GO:0072678)2.68622823
107negative regulation of erythrocyte differentiation (GO:0045647)2.67326064
108regulation of alpha-beta T cell proliferation (GO:0046640)2.66832499
109positive regulation of immunoglobulin mediated immune response (GO:0002891)2.66352500
110positive regulation of B cell mediated immunity (GO:0002714)2.66352500
111negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.66178350
112cellular response to interferon-alpha (GO:0035457)2.65772534
113natural killer cell mediated immunity (GO:0002228)2.63872167
114natural killer cell mediated cytotoxicity (GO:0042267)2.63872167
115myeloid leukocyte activation (GO:0002274)2.63433494
116alpha-linolenic acid metabolic process (GO:0036109)2.63107550
117regulation of tolerance induction (GO:0002643)2.62704249
118positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62053885
119positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.61950320
120positive regulation of lipid storage (GO:0010884)2.61009307
121G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.60872489
122lipopolysaccharide-mediated signaling pathway (GO:0031663)2.60375388
123cofactor catabolic process (GO:0051187)2.60152212
124positive regulation of natural killer cell differentiation (GO:0032825)2.58408701
125negative regulation of alpha-beta T cell activation (GO:0046636)2.58364713
126regulation of triglyceride catabolic process (GO:0010896)2.58191715
127interferon-gamma-mediated signaling pathway (GO:0060333)2.57912688
128apoptotic cell clearance (GO:0043277)2.56150124
129phospholipid homeostasis (GO:0055091)2.55566804
130positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.54826205
131positive regulation of antigen processing and presentation (GO:0002579)2.53807026
132regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.51871396
133L-phenylalanine metabolic process (GO:0006558)2.50969797
134erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.50969797
135positive regulation of chemokine biosynthetic process (GO:0045080)2.50820851
136detection of molecule of bacterial origin (GO:0032490)2.50615792
137positive regulation of interferon-beta production (GO:0032728)2.50375048
138erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.48681111
139L-phenylalanine catabolic process (GO:0006559)2.48681111
140phospholipid efflux (GO:0033700)2.47597111
141urea metabolic process (GO:0019627)2.45802826
142urea cycle (GO:0000050)2.45802826
143aromatic amino acid family catabolic process (GO:0009074)2.45092195
144negative regulation of viral genome replication (GO:0045071)2.43925894
145response to interferon-beta (GO:0035456)2.43522303
146cysteine metabolic process (GO:0006534)2.42247290
147indole-containing compound catabolic process (GO:0042436)2.41948816
148indolalkylamine catabolic process (GO:0046218)2.41948816
149tryptophan catabolic process (GO:0006569)2.41948816
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.41215393
151positive regulation of blood coagulation (GO:0030194)2.40924897
152positive regulation of hemostasis (GO:1900048)2.40924897
153aminoglycoside antibiotic metabolic process (GO:0030647)2.40754130
154antigen processing and presentation via MHC class Ib (GO:0002475)2.40604364
155B cell mediated immunity (GO:0019724)2.39638413
156regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39435617
157respiratory burst (GO:0045730)2.38916396
158JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.36824066
159fatty acid transmembrane transport (GO:1902001)2.36602166
160cellular response to virus (GO:0098586)2.36568868
161epoxygenase P450 pathway (GO:0019373)2.36525661
162tryptophan metabolic process (GO:0006568)2.36219059
163positive regulation of coagulation (GO:0050820)2.34958871
164aldehyde catabolic process (GO:0046185)2.34873917
165T-helper 1 type immune response (GO:0042088)2.34291387
166positive regulation of macrophage cytokine production (GO:0060907)2.34086198
167homocysteine metabolic process (GO:0050667)2.33665863
168kynurenine metabolic process (GO:0070189)2.33074649
169cytidine deamination (GO:0009972)2.32980130
170cytidine metabolic process (GO:0046087)2.32980130
171cytidine catabolic process (GO:0006216)2.32980130
172negative regulation of fibrinolysis (GO:0051918)2.32368879
173hormone catabolic process (GO:0042447)2.32274519
174primary alcohol catabolic process (GO:0034310)2.32074037

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.50514102
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.41889860
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.60898647
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.27533142
5IRF8_21731497_ChIP-ChIP_J774_Mouse4.21986390
6* IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.80295836
7* RXR_22158963_ChIP-Seq_LIVER_Mouse3.49045264
8* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.18993350
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93581046
10* LXR_22158963_ChIP-Seq_LIVER_Mouse2.91199342
11IRF8_27001747_Chip-Seq_BMDM_Mouse2.85532362
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.76512509
13SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70832227
14GATA1_22025678_ChIP-Seq_K562_Human2.59468590
15NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.58617871
16* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.56099701
17RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.45825898
18* FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.31321815
19SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.20933564
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.19927440
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.11242719
22* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02688985
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.99404373
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.98594140
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93207759
26* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92666606
27STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.89569023
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.83721020
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82236389
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.82078938
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.81600546
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75803944
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74997140
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.72617921
35GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.72556682
36STAT4_19710469_ChIP-ChIP_TH1__Mouse1.70574301
37RARG_19884340_ChIP-ChIP_MEFs_Mouse1.68321440
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.65779506
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63818307
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.61670635
41CLOCK_20551151_ChIP-Seq_293T_Human1.58966065
42SCL_19346495_ChIP-Seq_HPC-7_Human1.52254663
43STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.52102142
44* GATA3_27048872_Chip-Seq_THYMUS_Human1.46029706
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.44458841
46TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44299558
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.40852957
48* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.38864571
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37434669
50* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34100789
51MYC_22102868_ChIP-Seq_BL_Human1.33700926
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.30802666
53MAF_26560356_Chip-Seq_TH1_Human1.28590864
54CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27346157
55TRIM28_21343339_ChIP-Seq_HEK293_Human1.26117095
56MAF_26560356_Chip-Seq_TH2_Human1.24940543
57EGR1_19374776_ChIP-ChIP_THP-1_Human1.23619139
58SPI1_23547873_ChIP-Seq_NB4_Human1.21338561
59FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.20388316
60GATA3_26560356_Chip-Seq_TH2_Human1.20282396
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16489975
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16383083
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.15541560
64KDM2B_26808549_Chip-Seq_DND41_Human1.13166549
65* SPI1_23127762_ChIP-Seq_K562_Human1.11158687
66STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09614870
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08888316
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08326938
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08158328
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08158328
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08158328
72* FOXO3_23340844_ChIP-Seq_DLD1_Human1.07553089
73SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06663224
74RUNX_20019798_ChIP-Seq_JUKART_Human1.05387350
75* MYB_26560356_Chip-Seq_TH2_Human1.05316965
76MYB_26560356_Chip-Seq_TH1_Human1.04831543
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.03694935
78LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01974283
79ESR1_21235772_ChIP-Seq_MCF-7_Human1.01232483
80PU_27001747_Chip-Seq_BMDM_Mouse1.01022241
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.00643493
82HIF1A_21447827_ChIP-Seq_MCF-7_Human0.99668710
83CDX2_20551321_ChIP-Seq_CACO-2_Human0.98735299
84GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98267872
85GATA1_19941826_ChIP-Seq_K562_Human0.97473842
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95941484
87* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95480088
88* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.95440126
89VDR_24763502_ChIP-Seq_THP-1_Human0.95420817
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94997470
91FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.94715250
92TCF7_22412390_ChIP-Seq_EML_Mouse0.94367840
93* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94202488
94IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94120774
95VDR_24787735_ChIP-Seq_THP-1_Human0.92805241
96PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92791331
97BCL6_27268052_Chip-Seq_Bcells_Human0.92611053
98PPAR_26484153_Chip-Seq_NCI-H1993_Human0.91577023
99CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90992323
100SPI1_20517297_ChIP-Seq_HL60_Human0.90797797
101* GATA1_19941827_ChIP-Seq_MEL_Mouse0.90182580
102BCOR_27268052_Chip-Seq_Bcells_Human0.90168988
103SOX2_20726797_ChIP-Seq_SW620_Human0.89879412
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89103526
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.88645781
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88444644
107LXR_22292898_ChIP-Seq_THP-1_Human0.88266766
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87579800
109VDR_21846776_ChIP-Seq_THP-1_Human0.87447176
110RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86915467
111KDM2B_26808549_Chip-Seq_SUP-B15_Human0.85358151
112CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85295991
113* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84383476
114GATA2_19941826_ChIP-Seq_K562_Human0.84114058
115VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83839029
116STAT1_20625510_ChIP-Seq_HELA_Human0.83671258
117GATA4_25053715_ChIP-Seq_YYC3_Human0.82871293
118RACK7_27058665_Chip-Seq_MCF-7_Human0.82582689
119P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82392378
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81769344
121TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81740043
122CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81069313
123* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.80968744
124NCOR1_26117541_ChIP-Seq_K562_Human0.80880773
125PU.1_20513432_ChIP-Seq_Bcells_Mouse0.80676437
126UTX_26944678_Chip-Seq_JUKART_Human0.79998579

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.10946755
2MP0002139_abnormal_hepatobiliary_system2.93694953
3MP0005360_urolithiasis2.92203861
4MP0003191_abnormal_cellular_cholesterol2.88736465
5MP0003724_increased_susceptibility_to2.86312264
6MP0003436_decreased_susceptibility_to2.65746879
7MP0006082_CNS_inflammation2.64045529
8MP0009785_altered_susceptibility_to2.59487001
9MP0002254_reproductive_system_inflammat2.56528968
10MP0009840_abnormal_foam_cell2.41644332
11MP0005058_abnormal_lysosome_morphology2.33767483
12MP0008004_abnormal_stomach_pH2.33064483
13MP0005365_abnormal_bile_salt2.14907810
14MP0005025_abnormal_response_to2.05336715
15MP0008875_abnormal_xenobiotic_pharmacok2.02572721
16MP0000685_abnormal_immune_system2.00985583
17MP0005085_abnormal_gallbladder_physiolo1.97427691
18MP0002138_abnormal_hepatobiliary_system1.96330053
19MP0002419_abnormal_innate_immunity1.90964565
20MP0000465_gastrointestinal_hemorrhage1.90496571
21MP0002148_abnormal_hypersensitivity_rea1.90351306
22MP0003303_peritoneal_inflammation1.87470635
23MP0005387_immune_system_phenotype1.86364518
24MP0001790_abnormal_immune_system1.86364518
25MP0009764_decreased_sensitivity_to1.80619705
26MP0010329_abnormal_lipoprotein_level1.80592000
27MP0004510_myositis1.79412097
28MP0005000_abnormal_immune_tolerance1.78435242
29MP0000343_altered_response_to1.77519768
30MP0003705_abnormal_hypodermis_morpholog1.70165108
31MP0003763_abnormal_thymus_physiology1.68478690
32MP0003011_delayed_dark_adaptation1.64144164
33MP0001853_heart_inflammation1.60589975
34MP0003186_abnormal_redox_activity1.60554400
35MP0005671_abnormal_response_to1.58541125
36MP0002132_abnormal_respiratory_system1.58457734
37MP0008469_abnormal_protein_level1.57659362
38MP0010368_abnormal_lymphatic_system1.56797004
39MP0009333_abnormal_splenocyte_physiolog1.56615981
40MP0003252_abnormal_bile_duct1.55177452
41MP0005451_abnormal_body_composition1.54566755
42MP0005464_abnormal_platelet_physiology1.54445167
43MP0001800_abnormal_humoral_immune1.53467257
44MP0002452_abnormal_antigen_presenting1.53019914
45MP0008260_abnormal_autophagy1.52101828
46MP0000609_abnormal_liver_physiology1.51155638
47MP0002723_abnormal_immune_serum1.49795055
48MP0001533_abnormal_skeleton_physiology1.48815752
49MP0005167_abnormal_blood-brain_barrier1.45927207
50MP0004130_abnormal_muscle_cell1.42327681
51MP0005319_abnormal_enzyme/_coenzyme1.40507675
52MP0008438_abnormal_cutaneous_collagen1.39979660
53MP0001845_abnormal_inflammatory_respons1.36634493
54MP0005670_abnormal_white_adipose1.36003069
55MP0002722_abnormal_immune_system1.34291171
56MP0005083_abnormal_biliary_tract1.33212466
57MP0003300_gastrointestinal_ulcer1.32437551
58MP0004947_skin_inflammation1.32112308
59MP0004782_abnormal_surfactant_physiolog1.30917577
60MP0002332_abnormal_exercise_endurance1.28677991
61MP0003866_abnormal_defecation1.27915908
62MP0001819_abnormal_immune_cell1.26071045
63MP0001851_eye_inflammation1.25128229
64MP0003448_altered_tumor_morphology1.23945935
65MP0003806_abnormal_nucleotide_metabolis1.23515867
66MP0002420_abnormal_adaptive_immunity1.23368235
67MP0003075_altered_response_to1.22114477
68MP0002405_respiratory_system_inflammati1.21778461
69MP0005332_abnormal_amino_acid1.21648538
70MP0003828_pulmonary_edema1.20137697
71MP0010155_abnormal_intestine_physiology1.19756938
72MP0003172_abnormal_lysosome_physiology1.19719076
73MP0009763_increased_sensitivity_to1.17188109
74MP0004883_abnormal_blood_vessel1.16911399
75MP0003183_abnormal_peptide_metabolism1.16526775
76MP0002166_altered_tumor_susceptibility1.16023371
77MP0002118_abnormal_lipid_homeostasis1.13430169
78MP0005164_abnormal_response_to1.13208847
79MP0009643_abnormal_urine_homeostasis1.13123544
80MP0001879_abnormal_lymphatic_vessel1.10189655
81MP0005584_abnormal_enzyme/coenzyme_acti1.09065172
82MP0000858_altered_metastatic_potential1.05669654
83MP0003656_abnormal_erythrocyte_physiolo1.05319356
84MP0004019_abnormal_vitamin_homeostasis1.04596932
85MP0002998_abnormal_bone_remodeling1.04509577
86MP0000703_abnormal_thymus_morphology1.02127465
87MP0001663_abnormal_digestive_system1.01928743
88MP0000249_abnormal_blood_vessel1.01106417
89MP0003566_abnormal_cell_adhesion0.96650882
90MP0001545_abnormal_hematopoietic_system0.95566843
91MP0005397_hematopoietic_system_phenotyp0.95566843
92MP0005166_decreased_susceptibility_to0.94462131
93MP0000604_amyloidosis0.94006256
94MP0005666_abnormal_adipose_tissue0.93830394
95MP0000598_abnormal_liver_morphology0.92630019
96MP0009115_abnormal_fat_cell0.92210411
97MP0002136_abnormal_kidney_physiology0.92058662
98MP0000716_abnormal_immune_system0.91372468
99MP0002971_abnormal_brown_adipose0.90314568
100MP0004185_abnormal_adipocyte_glucose0.90086994
101MP0003690_abnormal_glial_cell0.89464985
102MP0004381_abnormal_hair_follicle0.87769251
103MP0009278_abnormal_bone_marrow0.87455407
104MP0005310_abnormal_salivary_gland0.87404249
105MP0005023_abnormal_wound_healing0.86813984
106MP0002006_tumorigenesis0.86111262
107MP0008874_decreased_physiological_sensi0.85041282
108MP0009765_abnormal_xenobiotic_induced0.84551648
109MP0003045_fibrosis0.84434935
110MP0000689_abnormal_spleen_morphology0.80990137
111MP0001958_emphysema0.80443503
112MP0003279_aneurysm0.80318367
113MP0000767_abnormal_smooth_muscle0.80106638
114MP0003195_calcinosis0.79749102
115MP0002429_abnormal_blood_cell0.79065855
116MP0001666_abnormal_nutrient_absorption0.78559077
117MP0005390_skeleton_phenotype0.78207217
118MP0002398_abnormal_bone_marrow0.75813354
119MP0006054_spinal_hemorrhage0.75749679
120MP0002277_abnormal_respiratory_mucosa0.75635189
121MP0003453_abnormal_keratinocyte_physiol0.74289579
122MP0003795_abnormal_bone_structure0.68118052
123MP0004808_abnormal_hematopoietic_stem0.67349217
124MP0003879_abnormal_hair_cell0.63624612
125MP0003091_abnormal_cell_migration0.63074560
126MP0005165_increased_susceptibility_to0.61994252
127MP0002933_joint_inflammation0.61955445
128MP0005535_abnormal_body_temperature0.61565030

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)6.19064162
2Abnormal platelet volume (HP:0011876)4.74883733
3Menorrhagia (HP:0000132)4.70271363
4Increased mean platelet volume (HP:0011877)4.44849143
5Stomatitis (HP:0010280)4.36082555
6Recurrent gram-negative bacterial infections (HP:0005420)4.33051875
7Optic neuritis (HP:0100653)4.31999286
8Retrobulbar optic neuritis (HP:0100654)4.31999286
9Eczematoid dermatitis (HP:0000976)4.29873131
10Systemic lupus erythematosus (HP:0002725)4.23627094
11Recurrent abscess formation (HP:0002722)3.87396084
12Autoimmune thrombocytopenia (HP:0001973)3.84274628
13Recurrent bacterial skin infections (HP:0005406)3.72453374
14Chronic obstructive pulmonary disease (HP:0006510)3.53237878
15Obstructive lung disease (HP:0006536)3.53237878
16Vacuolated lymphocytes (HP:0001922)3.50008868
17Complement deficiency (HP:0004431)3.39869207
18Abnormality of macrophages (HP:0004311)3.37381801
19Xanthomatosis (HP:0000991)3.37178355
20Gastrointestinal infarctions (HP:0005244)3.37113767
21Abnormality of the nasal mucosa (HP:0000433)3.33804563
22Joint hemorrhage (HP:0005261)3.33656268
23Encephalitis (HP:0002383)3.30336955
24Elevated erythrocyte sedimentation rate (HP:0003565)3.29524296
25Deep venous thrombosis (HP:0002625)3.22947646
26Myocardial infarction (HP:0001658)3.19105585
27Keratoconjunctivitis sicca (HP:0001097)3.15611294
28Meningitis (HP:0001287)3.12798299
29Axonal loss (HP:0003447)3.11976650
30Impaired platelet aggregation (HP:0003540)3.11527793
31Abnormal platelet function (HP:0011869)3.11527793
32Increased cerebral lipofuscin (HP:0011813)3.07047184
33Arterial thrombosis (HP:0004420)2.93530874
34T lymphocytopenia (HP:0005403)2.90304620
35Spontaneous hematomas (HP:0007420)2.89687051
36Keratoconjunctivitis (HP:0001096)2.87570998
37Orchitis (HP:0100796)2.85394589
38Myositis (HP:0100614)2.84197005
39Abnormality of complement system (HP:0005339)2.82710088
40Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82519209
41Chest pain (HP:0100749)2.81733966
42Abnormality of T cell number (HP:0011839)2.79837565
43Gingival bleeding (HP:0000225)2.79666581
44Nasal polyposis (HP:0100582)2.78337756
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.75384878
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.73597025
47Tetraparesis (HP:0002273)2.73111306
48Episodic fever (HP:0001954)2.72307896
49Prolonged partial thromboplastin time (HP:0003645)2.71514362
50Intrahepatic cholestasis (HP:0001406)2.69078671
51Esophageal varix (HP:0002040)2.67781005
52Abnormality of aromatic amino acid family metabolism (HP:0004338)2.67323322
53Purpura (HP:0000979)2.66211232
54Amyloidosis (HP:0011034)2.64090251
55Hematochezia (HP:0002573)2.63954528
56Gingivitis (HP:0000230)2.63824826
57Pulmonary infiltrates (HP:0002113)2.62768356
58Recurrent skin infections (HP:0001581)2.61133982
59Pulmonary embolism (HP:0002204)2.59892520
60Interstitial pulmonary disease (HP:0006530)2.59566569
61Hyperlipoproteinemia (HP:0010980)2.58859007
62Hepatosplenomegaly (HP:0001433)2.58473755
63Polycythemia (HP:0001901)2.58279453
64Hypoalphalipoproteinemia (HP:0003233)2.56656189
65Joint swelling (HP:0001386)2.55272061
66Abnormality of the intrinsic pathway (HP:0010989)2.54987592
67Glomerulonephritis (HP:0000099)2.54148256
68Increased IgE level (HP:0003212)2.52068422
69Inflammation of the large intestine (HP:0002037)2.51928859
70Hemoptysis (HP:0002105)2.51592240
71Leukocytosis (HP:0001974)2.50933779
72Abnormality of the common coagulation pathway (HP:0010990)2.49232202
73Abnormality of monocarboxylic acid metabolism (HP:0010996)2.48390582
74Chronic mucocutaneous candidiasis (HP:0002728)2.48063945
75Recurrent cutaneous fungal infections (HP:0011370)2.48063945
76Abnormality of proline metabolism (HP:0010907)2.46272789
77Hydroxyprolinuria (HP:0003080)2.46272789
78Anorexia (HP:0002039)2.44492682
79Hypercholesterolemia (HP:0003124)2.43321914
80Increased serum ferritin (HP:0003281)2.42763355
81Chronic otitis media (HP:0000389)2.39913406
82Gastrointestinal inflammation (HP:0004386)2.36851499
83Hypochromic anemia (HP:0001931)2.36377457
84Hyperglycinuria (HP:0003108)2.35134382
85Abnormality of iron homeostasis (HP:0011031)2.34375677
86Gangrene (HP:0100758)2.33983884
87Cellulitis (HP:0100658)2.33577596
88Abnormality of glycosphingolipid metabolism (HP:0004343)2.33428237
89Abnormality of glycolipid metabolism (HP:0010969)2.33428237
90Abnormality of liposaccharide metabolism (HP:0010968)2.33428237
91Dysostosis multiplex (HP:0000943)2.31295455
92Autoimmune hemolytic anemia (HP:0001890)2.30804737
93Nephritis (HP:0000123)2.30623782
94Abnormality of the heme biosynthetic pathway (HP:0010472)2.30204816
95Abnormality of purine metabolism (HP:0004352)2.28489409
96Recurrent fungal infections (HP:0002841)2.27031903
97Petechiae (HP:0000967)2.24959816
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.24467468
99Bruising susceptibility (HP:0000978)2.23079968
100Abnormality of T cells (HP:0002843)2.22805724
101Hyperammonemia (HP:0001987)2.21896676
102Peritonitis (HP:0002586)2.20837445
103Skin nodule (HP:0200036)2.19872038
104Epistaxis (HP:0000421)2.19055959
105Hemorrhage of the eye (HP:0011885)2.17937582
106Mediastinal lymphadenopathy (HP:0100721)2.17140368
107Poikilocytosis (HP:0004447)2.15380691
108Increased connective tissue (HP:0009025)2.13899154
109Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.13804263
110Abnormality of fatty-acid metabolism (HP:0004359)2.13183407
111Vertigo (HP:0002321)2.12427801
112Increased IgM level (HP:0003496)2.12305168
113Urticaria (HP:0001025)2.10565038
114Granulocytopenia (HP:0001913)2.10258277
115Abnormal cartilage morphology (HP:0002763)2.10149376
116Abnormality of transition element cation homeostasis (HP:0011030)2.09480840
117Hypolipoproteinemia (HP:0010981)2.08680748
118Nausea (HP:0002018)2.08524251
119Vasculitis (HP:0002633)2.08185774
120Hypergammaglobulinemia (HP:0010702)2.08086725
121Urinary glycosaminoglycan excretion (HP:0003541)2.06876147
122Mucopolysacchariduria (HP:0008155)2.06876147
123Conjunctival telangiectasia (HP:0000524)2.06773432
124Loss of speech (HP:0002371)2.06739897
125Colitis (HP:0002583)2.06093344
126Multiple enchondromatosis (HP:0005701)2.05533321
127Hypertriglyceridemia (HP:0002155)2.04417322
128Osteomyelitis (HP:0002754)2.00700974
129Glomerulopathy (HP:0100820)1.99914917
130Pustule (HP:0200039)1.98845795
131Ketosis (HP:0001946)1.98430611
132Hypoglycemic coma (HP:0001325)1.97888277
133Upper motor neuron abnormality (HP:0002127)1.97376471
134Asymmetric septal hypertrophy (HP:0001670)1.96220438
135Arthralgia (HP:0002829)1.95896478
136Recurrent viral infections (HP:0004429)1.95776265
137Abnormality of the pleura (HP:0002103)1.95496316
138Basal ganglia calcification (HP:0002135)1.95016102
139Acute hepatic failure (HP:0006554)1.94629336
140Epidermoid cyst (HP:0200040)1.94467474
141Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94419210
142Gastrointestinal stroma tumor (HP:0100723)1.92847962
143Eosinophilia (HP:0001880)1.91347887
144Thrombophlebitis (HP:0004418)1.90440464
145Lymphopenia (HP:0001888)1.90072276
146Hypochromic microcytic anemia (HP:0004840)1.89953504
147Abnormality of mucopolysaccharide metabolism (HP:0011020)1.89767923
148Abnormality of polysaccharide metabolism (HP:0011012)1.89767923
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.89767923
150Abnormality of glycine metabolism (HP:0010895)1.88409431
151Abnormality of serine family amino acid metabolism (HP:0010894)1.88409431
152Osteolytic defects of the hand bones (HP:0009699)1.86832446
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.86832446
154Microcytic anemia (HP:0001935)1.86218743
155Abnormality of nucleobase metabolism (HP:0010932)1.85657179
156Periodontitis (HP:0000704)1.85231876

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.82627147
2TGFBR23.43072885
3TYK23.07240234
4TBK12.96653457
5FGFR42.33835277
6KIT2.23746407
7TIE12.11607844
8BLK2.11576943
9IKBKE2.09955260
10MAP3K142.08249682
11FES2.07176637
12PBK2.05480493
13IRAK32.05202438
14JAK12.00256756
15CDK122.00256697
16TNK21.96818092
17KDR1.89815974
18CSF1R1.86159584
19JAK31.85462344
20TRIB31.80965933
21IKBKB1.73789960
22GRK61.68059833
23TAOK11.56165967
24PRPF4B1.52774047
25BCKDK1.52547813
26PIM21.51060799
27MATK1.48560743
28MST1R1.46738271
29EPHB11.46042669
30FGFR31.44354025
31TAOK21.43551977
32MAP2K31.42467137
33TAOK31.41912182
34MAP4K11.41187742
35CSK1.40844686
36IRAK41.40584322
37GRK11.40022367
38STK101.33976795
39EPHA31.33201749
40BMPR21.32809644
41GRK71.31721988
42GRK51.30344640
43NEK91.30226398
44TTN1.25734790
45SIK11.22362582
46JAK21.21553917
47PTK2B1.19371209
48RIPK11.19126455
49SIK31.17162152
50ZAP701.13956712
51RIPK41.13806336
52MAP3K11.09289798
53ABL21.07358905
54MAP3K31.00698145
55NME20.98063468
56ADRBK20.98023898
57CHUK0.97322723
58PDK10.92407822
59TESK20.90989314
60BMX0.89408115
61TEC0.88540042
62PRKG20.85698595
63HCK0.85057177
64PTK60.84109540
65MAP3K100.83006993
66MOS0.82696649
67LRRK20.81392029
68CAMK1D0.81046778
69PKN20.78779605
70PIK3CG0.78431114
71FLT30.77806826
72ITK0.76511515
73TXK0.75678266
74YES10.75489038
75SYK0.74484444
76IRAK20.71960369
77PIM10.70770179
78BTK0.69760498
79MAPK70.69059098
80MAP3K130.66996213
81CDC42BPA0.65238289
82HIPK20.63063699
83MAPK120.63012084
84KSR20.62780124
85STK40.62237154
86LCK0.60794512
87PAK40.59877922
88LYN0.59104793
89PRKD20.58832065
90FYN0.57754761
91RPS6KA40.57615042
92MAPK110.57035478
93CDK60.55310982
94ACVR1B0.55284757
95MARK20.55221243
96PRKAA20.54204197
97MYLK0.53989420
98MAP3K70.53106311
99PRKCQ0.51981332
100NLK0.51727239
101TGFBR10.51694154
102ABL10.51168908
103EGFR0.51034558
104IGF1R0.50603808
105PRKCD0.50039504
106RET0.49983675
107MAP3K50.48440605
108CAMK40.48203210
109MAP3K110.47697005
110TRPM70.46447312
111MAPK40.45518942
112PRKD10.45064329
113EIF2AK10.44903566
114DAPK20.43839904
115SGK30.43408365
116IRAK10.42889172
117EIF2AK20.41828505
118MST40.41735851
119MAP3K60.40740908
120PDGFRA0.40119385
121DYRK1B0.39020627
122INSRR0.38140653
123MAPKAPK20.37245618
124LMTK20.37016426
125MET0.36515483
126MARK30.36383196
127GSK3A0.34386059
128FGR0.33710032
129ARAF0.33498407
130PDPK10.33464978
131MAP3K20.32842466
132RAF10.31884953
133PAK10.30978414
134MAP2K60.29554335
135STK240.29206911
136SGK20.28860258

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051502.98756734
2Complement and coagulation cascades_Homo sapiens_hsa046102.62758158
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.53762947
4Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40275217
5Caffeine metabolism_Homo sapiens_hsa002322.33308695
6Autoimmune thyroid disease_Homo sapiens_hsa053202.32427965
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09206113
8Platelet activation_Homo sapiens_hsa046112.08589510
9PPAR signaling pathway_Homo sapiens_hsa033202.06419875
10Fatty acid degradation_Homo sapiens_hsa000712.00435356
11Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.95248305
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.94161728
13Tryptophan metabolism_Homo sapiens_hsa003801.90710182
14Leishmaniasis_Homo sapiens_hsa051401.84447672
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77079002
16Arginine biosynthesis_Homo sapiens_hsa002201.70608499
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69896733
18Type I diabetes mellitus_Homo sapiens_hsa049401.62897651
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.62323686
20RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.61623131
21Lysosome_Homo sapiens_hsa041421.59429095
22Glycosaminoglycan degradation_Homo sapiens_hsa005311.58242666
23Peroxisome_Homo sapiens_hsa041461.51744902
24Nitrogen metabolism_Homo sapiens_hsa009101.50299588
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.48538891
26Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.47984412
27Malaria_Homo sapiens_hsa051441.47507055
28T cell receptor signaling pathway_Homo sapiens_hsa046601.43707885
29Other glycan degradation_Homo sapiens_hsa005111.41041190
30Pertussis_Homo sapiens_hsa051331.34427641
31Chemical carcinogenesis_Homo sapiens_hsa052041.33534919
32Osteoclast differentiation_Homo sapiens_hsa043801.27147334
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26305605
34Intestinal immune network for IgA production_Homo sapiens_hsa046721.24848028
35Propanoate metabolism_Homo sapiens_hsa006401.22985117
36Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.22450005
37SNARE interactions in vesicular transport_Homo sapiens_hsa041301.20683376
38Fatty acid metabolism_Homo sapiens_hsa012121.19720526
39Histidine metabolism_Homo sapiens_hsa003401.18635376
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.18299422
41Legionellosis_Homo sapiens_hsa051341.18243982
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.16871008
43Starch and sucrose metabolism_Homo sapiens_hsa005001.16516014
44Tuberculosis_Homo sapiens_hsa051521.15080398
45Measles_Homo sapiens_hsa051621.13917848
46beta-Alanine metabolism_Homo sapiens_hsa004101.13587754
47ABC transporters_Homo sapiens_hsa020101.11757426
48Adipocytokine signaling pathway_Homo sapiens_hsa049201.10906374
49Allograft rejection_Homo sapiens_hsa053301.10508823
50Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.05200220
51Influenza A_Homo sapiens_hsa051641.03708371
52Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03252494
53Graft-versus-host disease_Homo sapiens_hsa053321.02334204
54Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.00984102
55Toxoplasmosis_Homo sapiens_hsa051450.99955489
56Shigellosis_Homo sapiens_hsa051310.98710963
57Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.98236880
58TNF signaling pathway_Homo sapiens_hsa046680.96673488
59Retinol metabolism_Homo sapiens_hsa008300.96300485
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95900955
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.95769115
62Jak-STAT signaling pathway_Homo sapiens_hsa046300.94098119
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93108281
64Apoptosis_Homo sapiens_hsa042100.91201529
65Hepatitis B_Homo sapiens_hsa051610.89807203
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89118052
67African trypanosomiasis_Homo sapiens_hsa051430.88858561
68Non-small cell lung cancer_Homo sapiens_hsa052230.87839448
69Galactose metabolism_Homo sapiens_hsa000520.86805939
70Pancreatic cancer_Homo sapiens_hsa052120.86736097
71Hepatitis C_Homo sapiens_hsa051600.86302408
72Rheumatoid arthritis_Homo sapiens_hsa053230.83100184
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.82736245
74Selenocompound metabolism_Homo sapiens_hsa004500.80318276
75Phenylalanine metabolism_Homo sapiens_hsa003600.79983495
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.78960456
77Endocytosis_Homo sapiens_hsa041440.78204883
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.78198518
79Herpes simplex infection_Homo sapiens_hsa051680.77877371
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.77716994
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77663126
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76875032
83Folate biosynthesis_Homo sapiens_hsa007900.76556433
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76130916
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76108422
86Vitamin B6 metabolism_Homo sapiens_hsa007500.75489554
87B cell receptor signaling pathway_Homo sapiens_hsa046620.75142382
88Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75103975
89Antigen processing and presentation_Homo sapiens_hsa046120.74187021
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74027828
91Phagosome_Homo sapiens_hsa041450.73918385
92Fructose and mannose metabolism_Homo sapiens_hsa000510.73248197
93Bile secretion_Homo sapiens_hsa049760.72618019
94Insulin resistance_Homo sapiens_hsa049310.71965173
95Hematopoietic cell lineage_Homo sapiens_hsa046400.69598565
96Carbon metabolism_Homo sapiens_hsa012000.67731035
97Fat digestion and absorption_Homo sapiens_hsa049750.67511351
98Asthma_Homo sapiens_hsa053100.65815350
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.65604584
100Chronic myeloid leukemia_Homo sapiens_hsa052200.64854945
101Pentose phosphate pathway_Homo sapiens_hsa000300.64586369
102Glycerolipid metabolism_Homo sapiens_hsa005610.64381952
103VEGF signaling pathway_Homo sapiens_hsa043700.64107703
104Sulfur relay system_Homo sapiens_hsa041220.60474817
105Vitamin digestion and absorption_Homo sapiens_hsa049770.59686800
106Systemic lupus erythematosus_Homo sapiens_hsa053220.58780142
107Prolactin signaling pathway_Homo sapiens_hsa049170.56442631
108Viral carcinogenesis_Homo sapiens_hsa052030.56335590
109Viral myocarditis_Homo sapiens_hsa054160.55964759
110Primary immunodeficiency_Homo sapiens_hsa053400.55532084
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.55052010
112Tyrosine metabolism_Homo sapiens_hsa003500.55039687
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54066464
114Salmonella infection_Homo sapiens_hsa051320.53907328
115Renal cell carcinoma_Homo sapiens_hsa052110.53421574
116Acute myeloid leukemia_Homo sapiens_hsa052210.52964319
117Collecting duct acid secretion_Homo sapiens_hsa049660.52953374
118Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52935582
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52931002
120Amoebiasis_Homo sapiens_hsa051460.52000116
121Butanoate metabolism_Homo sapiens_hsa006500.51433444
122Arachidonic acid metabolism_Homo sapiens_hsa005900.49839708
123AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.47089909
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.44213862
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.44091540
126FoxO signaling pathway_Homo sapiens_hsa040680.43198112
127Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41922525
128Chemokine signaling pathway_Homo sapiens_hsa040620.41600368
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41582705
130Glutathione metabolism_Homo sapiens_hsa004800.40961562
131Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40656602
132Epstein-Barr virus infection_Homo sapiens_hsa051690.39970320
133Glycerophospholipid metabolism_Homo sapiens_hsa005640.37312567
134Notch signaling pathway_Homo sapiens_hsa043300.36850965
135HIF-1 signaling pathway_Homo sapiens_hsa040660.36433456
136Choline metabolism in cancer_Homo sapiens_hsa052310.35769981
137Type II diabetes mellitus_Homo sapiens_hsa049300.35383265
138Endometrial cancer_Homo sapiens_hsa052130.35226066
139Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34592132
140Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34226043
141HTLV-I infection_Homo sapiens_hsa051660.30697707
142Carbohydrate digestion and absorption_Homo sapiens_hsa049730.29968367
143Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29698721
144Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29638007

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