TMEM14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)4.91755711
2axon ensheathment in central nervous system (GO:0032291)4.78609451
3central nervous system myelination (GO:0022010)4.78609451
4presynaptic membrane assembly (GO:0097105)4.78328735
5presynaptic membrane organization (GO:0097090)4.69159977
6synaptic vesicle exocytosis (GO:0016079)4.46818774
7negative regulation of synaptic transmission, GABAergic (GO:0032229)4.40579309
8neuronal action potential propagation (GO:0019227)4.25975141
9protein localization to synapse (GO:0035418)4.19572968
10vocalization behavior (GO:0071625)4.06136569
11mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95715414
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.95382834
13protein complex biogenesis (GO:0070271)3.92431410
14negative regulation of neurotransmitter transport (GO:0051589)3.83429116
15gamma-aminobutyric acid signaling pathway (GO:0007214)3.81251458
16glutamate secretion (GO:0014047)3.75981982
17neuron-neuron synaptic transmission (GO:0007270)3.75549732
18glutamate receptor signaling pathway (GO:0007215)3.73069390
19ionotropic glutamate receptor signaling pathway (GO:0035235)3.72460609
20regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69497811
21respiratory chain complex IV assembly (GO:0008535)3.66729554
22positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.61536857
23neurotransmitter-gated ion channel clustering (GO:0072578)3.61191631
24mitochondrial respiratory chain complex assembly (GO:0033108)3.60584403
25regulation of glutamate secretion (GO:0014048)3.59745864
26regulation of short-term neuronal synaptic plasticity (GO:0048172)3.59517068
27response to histamine (GO:0034776)3.57757707
28mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.56977344
29postsynaptic membrane organization (GO:0001941)3.51859471
30behavioral response to cocaine (GO:0048148)3.51021958
31establishment of protein localization to mitochondrial membrane (GO:0090151)3.50779155
32long-chain fatty acid biosynthetic process (GO:0042759)3.50566374
33synaptic transmission, glutamatergic (GO:0035249)3.47530930
34regulation of synaptic vesicle exocytosis (GO:2000300)3.46701853
35regulation of glutamate receptor signaling pathway (GO:1900449)3.43311943
36neurotransmitter uptake (GO:0001504)3.39471762
37transmission of nerve impulse (GO:0019226)3.38458106
38ATP synthesis coupled proton transport (GO:0015986)3.36854478
39energy coupled proton transport, down electrochemical gradient (GO:0015985)3.36854478
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.35024613
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.35024613
42NADH dehydrogenase complex assembly (GO:0010257)3.35024613
43fatty acid elongation (GO:0030497)3.34394770
44neuron recognition (GO:0008038)3.31453342
45synaptic transmission, dopaminergic (GO:0001963)3.29881092
46water-soluble vitamin biosynthetic process (GO:0042364)3.28904242
47energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.27145868
48ATP hydrolysis coupled proton transport (GO:0015991)3.27145868
49G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24992129
50protein localization to cilium (GO:0061512)3.21719374
51long-term synaptic potentiation (GO:0060291)3.21568431
52respiratory electron transport chain (GO:0022904)3.21557908
53cytochrome complex assembly (GO:0017004)3.20894637
54positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19706545
55pyrimidine nucleobase catabolic process (GO:0006208)3.18029118
56proteasome assembly (GO:0043248)3.17723011
57positive regulation of synapse assembly (GO:0051965)3.17455000
58membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15228900
59regulation of dopamine metabolic process (GO:0042053)3.14685392
60regulation of catecholamine metabolic process (GO:0042069)3.14685392
61electron transport chain (GO:0022900)3.14206845
62positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.12828828
63regulation of excitatory postsynaptic membrane potential (GO:0060079)3.10905457
64regulation of voltage-gated calcium channel activity (GO:1901385)3.03540573
65cullin deneddylation (GO:0010388)3.03001724
66platelet dense granule organization (GO:0060155)3.01579846
67regulation of synaptic vesicle transport (GO:1902803)3.01352163
68cerebellar granule cell differentiation (GO:0021707)3.00238503
69regulation of hexokinase activity (GO:1903299)3.00146201
70regulation of glucokinase activity (GO:0033131)3.00146201
71chaperone-mediated protein transport (GO:0072321)3.00019600
72regulation of postsynaptic membrane potential (GO:0060078)2.99965210
73nonmotile primary cilium assembly (GO:0035058)2.99738863
74regulation of cilium movement (GO:0003352)2.98294725
75behavioral response to nicotine (GO:0035095)2.98267706
76nucleobase catabolic process (GO:0046113)2.98137317
77cellular ketone body metabolic process (GO:0046950)2.97406822
78epithelial cilium movement (GO:0003351)2.97014949
79neurotransmitter secretion (GO:0007269)2.96787702
80neuron remodeling (GO:0016322)2.95535558
81hydrogen ion transmembrane transport (GO:1902600)2.95501566
82positive regulation of neurotransmitter secretion (GO:0001956)2.94978765
83intraciliary transport (GO:0042073)2.94455731
84gamma-aminobutyric acid transport (GO:0015812)2.92500130
85regulation of synaptic transmission, glutamatergic (GO:0051966)2.91538792
86protein neddylation (GO:0045116)2.91304769
87positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.90601031
88regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89462382
89regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.89310612
90transferrin transport (GO:0033572)2.86452769
91regulation of neuronal synaptic plasticity (GO:0048168)2.85407524
92negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84882049
93dopamine transport (GO:0015872)2.84613982
94neurotransmitter transport (GO:0006836)2.84080191
95ketone body metabolic process (GO:1902224)2.83036057
96positive regulation of neurotransmitter transport (GO:0051590)2.82954993
97negative regulation of amino acid transport (GO:0051956)2.82933933
98startle response (GO:0001964)2.82280374
99regulation of neurotransmitter uptake (GO:0051580)2.81431039
100regulation of mitochondrial translation (GO:0070129)2.80955163
101fear response (GO:0042596)2.80437175
102mechanosensory behavior (GO:0007638)2.79234804
103regulation of vesicle fusion (GO:0031338)2.78586442
104proton transport (GO:0015992)2.77701822
105regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76780411
106regulation of synaptic plasticity (GO:0048167)2.76700563
107female mating behavior (GO:0060180)2.75034515
108axonal fasciculation (GO:0007413)2.73860174
109hydrogen transport (GO:0006818)2.73852149
110substantia nigra development (GO:0021762)2.73567757
111protein deneddylation (GO:0000338)2.73360022
112synaptic vesicle docking involved in exocytosis (GO:0016081)2.72801428
113behavioral defense response (GO:0002209)2.72399008
114behavioral fear response (GO:0001662)2.72399008
115regulation of neurotransmitter secretion (GO:0046928)2.71913876
116negative regulation of synaptic transmission (GO:0050805)2.71527984
117adult walking behavior (GO:0007628)2.71213570
118anterograde synaptic vesicle transport (GO:0048490)2.71133598
119regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.71102226
120regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.71102226
121L-amino acid import (GO:0043092)2.70899466
122anterograde axon cargo transport (GO:0008089)2.69595791
123synaptic vesicle maturation (GO:0016188)2.69578690
124negative regulation of neurotransmitter secretion (GO:0046929)2.68053493
125striatum development (GO:0021756)2.68009173
126calcium-mediated signaling using intracellular calcium source (GO:0035584)2.67993352
127sequestering of actin monomers (GO:0042989)2.67925833
128learning (GO:0007612)2.67715363
129positive regulation of membrane potential (GO:0045838)2.66371015
130regulation of respiratory system process (GO:0044065)2.66307568
131synaptic vesicle endocytosis (GO:0048488)2.65247911
132positive regulation of mitochondrial fission (GO:0090141)2.65122538
133regulation of neurotransmitter transport (GO:0051588)2.64495871
134ferric iron transport (GO:0015682)2.64494512
135protein-cofactor linkage (GO:0018065)2.62318959
136neurofilament cytoskeleton organization (GO:0060052)2.56022188
137aldehyde catabolic process (GO:0046185)2.53914411
138retinal ganglion cell axon guidance (GO:0031290)2.53583241
139ATP biosynthetic process (GO:0006754)2.49112953
140cilium movement (GO:0003341)2.46678739
141inositol phosphate catabolic process (GO:0071545)2.46128466
142organelle disassembly (GO:1903008)2.42170139
143transcription elongation from RNA polymerase III promoter (GO:0006385)2.41982065
144termination of RNA polymerase III transcription (GO:0006386)2.41982065
145righting reflex (GO:0060013)2.40652567
146mannosylation (GO:0097502)2.39113260
147axoneme assembly (GO:0035082)2.37520518
148purine nucleoside triphosphate biosynthetic process (GO:0009145)2.35502203
149cilium morphogenesis (GO:0060271)2.35313743
150positive regulation of meiosis (GO:0045836)2.33700597
151dendritic spine morphogenesis (GO:0060997)2.30586035
152purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.30485422
153establishment of melanosome localization (GO:0032401)2.28932981
154intracellular protein transmembrane import (GO:0044743)2.27482783
155inner mitochondrial membrane organization (GO:0007007)2.26344136
156detection of calcium ion (GO:0005513)2.26182974
157protein polyglutamylation (GO:0018095)2.25484853
158short-term memory (GO:0007614)2.24916384
159melanosome transport (GO:0032402)2.24636556
160regulation of microtubule-based movement (GO:0060632)2.22679659
161cilium organization (GO:0044782)2.22077273
162regulation of meiosis I (GO:0060631)2.22060898
163cilium assembly (GO:0042384)2.21813368
164keratinocyte development (GO:0003334)2.21650309
165GPI anchor metabolic process (GO:0006505)2.21633850
166C-terminal protein lipidation (GO:0006501)2.21597939
167L-phenylalanine catabolic process (GO:0006559)2.21102509
168erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.21102509
169auditory behavior (GO:0031223)2.20796510
170phosphorylated carbohydrate dephosphorylation (GO:0046838)2.18381382
171inositol phosphate dephosphorylation (GO:0046855)2.18381382
172positive regulation of meiotic cell cycle (GO:0051446)2.18060993
173erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.17632379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.83501367
2GBX2_23144817_ChIP-Seq_PC3_Human4.42328997
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.09287135
4TAF15_26573619_Chip-Seq_HEK293_Human2.96978318
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.96092762
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.84104603
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.77222613
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.73421662
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52338508
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.50041318
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.48836641
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43406210
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.40318202
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.40318202
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.38164965
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.35363613
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.34888869
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34567110
19HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31429274
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25620157
21MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24116275
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.21159712
23CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19179624
24REST_21632747_ChIP-Seq_MESCs_Mouse2.18092886
25EST1_17652178_ChIP-ChIP_JURKAT_Human2.07744388
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.06196656
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94561724
28AR_21572438_ChIP-Seq_LNCaP_Human1.94346835
29P300_19829295_ChIP-Seq_ESCs_Human1.91013294
30FUS_26573619_Chip-Seq_HEK293_Human1.89500151
31GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.88806344
32VDR_22108803_ChIP-Seq_LS180_Human1.87198543
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.86673891
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85305868
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.84144173
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.83850373
37RNF2_27304074_Chip-Seq_ESCs_Mouse1.83432897
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.80431872
39NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.76081256
40RARB_27405468_Chip-Seq_BRAIN_Mouse1.74205393
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.72450052
42REST_18959480_ChIP-ChIP_MESCs_Mouse1.70849266
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66826856
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.65604911
45OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.65124964
46NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.62413485
47ELK1_19687146_ChIP-ChIP_HELA_Human1.60146767
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.59431129
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.59025529
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.57656154
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56229332
52TOP2B_26459242_ChIP-Seq_MCF-7_Human1.54274408
53SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49014625
54DROSHA_22980978_ChIP-Seq_HELA_Human1.48028356
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.46459499
56ER_23166858_ChIP-Seq_MCF-7_Human1.45921910
57RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44829641
58UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44605554
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40806877
60HTT_18923047_ChIP-ChIP_STHdh_Human1.38450763
61AR_25329375_ChIP-Seq_VCAP_Human1.38302106
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.37627752
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35221800
64CBP_20019798_ChIP-Seq_JUKART_Human1.35221800
65RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.33086691
66HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32607278
67TP53_22573176_ChIP-Seq_HFKS_Human1.31690178
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.31388875
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30578022
70NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30397128
71JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.28808750
72ETS1_20019798_ChIP-Seq_JURKAT_Human1.27463188
73PRDM14_20953172_ChIP-Seq_ESCs_Human1.27320271
74RNF2_27304074_Chip-Seq_NSC_Mouse1.26997188
75* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26829610
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.26738588
77CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.26208264
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25973215
79MYC_18940864_ChIP-ChIP_HL60_Human1.24512663
80IGF1R_20145208_ChIP-Seq_DFB_Human1.24295402
81CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.22978710
82ZNF274_21170338_ChIP-Seq_K562_Hela1.20083305
83BCAT_22108803_ChIP-Seq_LS180_Human1.18980594
84* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18779453
85STAT3_23295773_ChIP-Seq_U87_Human1.17351484
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.16497443
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.13712941
88SRF_21415370_ChIP-Seq_HL-1_Mouse1.13648524
89FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13516160
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.13389560
91PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13150777
92RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13130852
93RUNX2_22187159_ChIP-Seq_PCA_Human1.11981324
94VDR_23849224_ChIP-Seq_CD4+_Human1.11920896
95JUN_21703547_ChIP-Seq_K562_Human1.11593935
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11209470
97* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.10819201
98SMAD_19615063_ChIP-ChIP_OVARY_Human1.10516650
99TCF4_23295773_ChIP-Seq_U87_Human1.10321107
100TP53_18474530_ChIP-ChIP_U2OS_Human1.09801271
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09142975
102EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.09057383
103KLF5_20875108_ChIP-Seq_MESCs_Mouse1.08725574
104TCF4_22108803_ChIP-Seq_LS180_Human1.08655649
105* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07516451
106MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07461753
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07415030
108EWS_26573619_Chip-Seq_HEK293_Human1.07025248
109* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06821273
110PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06366135
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05763743
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05718764
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.05718764
114MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05058090
115* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03888977
116* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03888977
117MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.03042396
118MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.02066182
119ERG_21242973_ChIP-ChIP_JURKAT_Human1.01933302
120E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.01107733
121* E2F1_18555785_Chip-Seq_ESCs_Mouse1.00943024
122* NFE2_27457419_Chip-Seq_LIVER_Mouse1.00783041
123* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00149032
124ARNT_22903824_ChIP-Seq_MCF-7_Human1.00106598
125* EZH2_27294783_Chip-Seq_NPCs_Mouse0.99809032
126* STAT3_18555785_Chip-Seq_ESCs_Mouse0.99143272
127KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.98992848
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98799595
129KDM2B_26808549_Chip-Seq_REH_Human0.98444561
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96730380
131SOX9_26525672_Chip-Seq_HEART_Mouse0.96381029
132TP53_16413492_ChIP-PET_HCT116_Human0.96252749
133* P53_22387025_ChIP-Seq_ESCs_Mouse0.96123175
134* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.91723496
135CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91256694
136TAL1_26923725_Chip-Seq_HPCs_Mouse0.90040932
137NANOG_19829295_ChIP-Seq_ESCs_Human0.89633859
138SOX2_19829295_ChIP-Seq_ESCs_Human0.89633859
139* FLI1_27457419_Chip-Seq_LIVER_Mouse0.88940731

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.43783351
2MP0004859_abnormal_synaptic_plasticity4.13476951
3MP0003635_abnormal_synaptic_transmissio3.37286671
4MP0004270_analgesia3.26256679
5MP0009745_abnormal_behavioral_response3.23960818
6MP0002064_seizures3.02056542
7MP0001968_abnormal_touch/_nociception2.92666031
8MP0001529_abnormal_vocalization2.92403294
9MP0009046_muscle_twitch2.79430130
10MP0002272_abnormal_nervous_system2.78865634
11MP0002063_abnormal_learning/memory/cond2.75471218
12MP0002736_abnormal_nociception_after2.69048077
13MP0002572_abnormal_emotion/affect_behav2.63952754
14MP0001486_abnormal_startle_reflex2.53518134
15MP0001440_abnormal_grooming_behavior2.44721616
16MP0002734_abnormal_mechanical_nocicepti2.43940836
17MP0001905_abnormal_dopamine_level2.36145761
18MP0002735_abnormal_chemical_nociception2.28178244
19MP0002822_catalepsy2.19481619
20MP0001501_abnormal_sleep_pattern2.19121020
21MP0008877_abnormal_DNA_methylation2.13688088
22MP0002638_abnormal_pupillary_reflex2.12337948
23MP0006276_abnormal_autonomic_nervous2.05769054
24MP0005423_abnormal_somatic_nervous2.01653192
25MP0003329_amyloid_beta_deposits2.00620452
26MP0001970_abnormal_pain_threshold1.98399392
27MP0002733_abnormal_thermal_nociception1.96355529
28MP0003195_calcinosis1.95031638
29MP0002067_abnormal_sensory_capabilities1.94011578
30MP0004142_abnormal_muscle_tone1.92266928
31MP0002102_abnormal_ear_morphology1.83752381
32MP0000778_abnormal_nervous_system1.82299559
33MP0003121_genomic_imprinting1.80440413
34MP0005084_abnormal_gallbladder_morpholo1.79864291
35MP0000920_abnormal_myelination1.77993389
36MP0000372_irregular_coat_pigmentation1.70897621
37MP0002938_white_spotting1.70526421
38MP0004924_abnormal_behavior1.69872131
39MP0005386_behavior/neurological_phenoty1.69872131
40MP0005646_abnormal_pituitary_gland1.69036180
41MP0009780_abnormal_chondrocyte_physiolo1.68324363
42MP0005171_absent_coat_pigmentation1.62173415
43MP0001188_hyperpigmentation1.55745280
44MP0001984_abnormal_olfaction1.53834258
45MP0008569_lethality_at_weaning1.48011682
46MP0008875_abnormal_xenobiotic_pharmacok1.47942957
47MP0002184_abnormal_innervation1.46070049
48MP0002557_abnormal_social/conspecific_i1.45893437
49MP0002837_dystrophic_cardiac_calcinosis1.45857914
50MP0003136_yellow_coat_color1.40264493
51MP0005253_abnormal_eye_physiology1.38893619
52MP0000955_abnormal_spinal_cord1.33141279
53MP0002066_abnormal_motor_capabilities/c1.32830850
54MP0002882_abnormal_neuron_morphology1.31193491
55MP0004742_abnormal_vestibular_system1.28247424
56MP0003879_abnormal_hair_cell1.27178411
57MP0005551_abnormal_eye_electrophysiolog1.27157131
58MP0004885_abnormal_endolymph1.26337228
59MP0003633_abnormal_nervous_system1.25851421
60MP0004145_abnormal_muscle_electrophysio1.24901669
61MP0008789_abnormal_olfactory_epithelium1.23944014
62MP0001502_abnormal_circadian_rhythm1.22495111
63MP0002229_neurodegeneration1.22315725
64MP0002163_abnormal_gland_morphology1.22101220
65MP0003011_delayed_dark_adaptation1.21945319
66MP0003634_abnormal_glial_cell1.19953508
67MP0002876_abnormal_thyroid_physiology1.19390886
68MP0003631_nervous_system_phenotype1.14653451
69MP0001963_abnormal_hearing_physiology1.14161030
70MP0003690_abnormal_glial_cell1.13229843
71MP0005085_abnormal_gallbladder_physiolo1.12880526
72MP0003186_abnormal_redox_activity1.11914050
73MP0003122_maternal_imprinting1.11793909
74MP0004811_abnormal_neuron_physiology1.08427623
75MP0000569_abnormal_digit_pigmentation1.08365104
76MP0001485_abnormal_pinna_reflex1.07965490
77MP0008872_abnormal_physiological_respon1.07692448
78MP0002928_abnormal_bile_duct1.07518543
79MP0004133_heterotaxia1.07216924
80MP0005187_abnormal_penis_morphology1.05110016
81MP0003950_abnormal_plasma_membrane1.03424355
82MP0005409_darkened_coat_color1.03359768
83MP0010386_abnormal_urinary_bladder1.00120031
84MP0003283_abnormal_digestive_organ0.97112315
85MP0006036_abnormal_mitochondrial_physio0.95436509
86MP0002139_abnormal_hepatobiliary_system0.95245863
87MP0001664_abnormal_digestion0.95032285
88MP0003123_paternal_imprinting0.94750803
89MP0005408_hypopigmentation0.94746300
90MP0000604_amyloidosis0.94679279
91MP0006035_abnormal_mitochondrial_morpho0.94408925
92MP0003718_maternal_effect0.94175652
93MP0002752_abnormal_somatic_nervous0.94039227
94MP0004858_abnormal_nervous_system0.94009703
95MP0008058_abnormal_DNA_repair0.93964450
96MP0005332_abnormal_amino_acid0.93795479
97MP0005410_abnormal_fertilization0.92750865
98MP0000427_abnormal_hair_cycle0.91686717
99MP0004043_abnormal_pH_regulation0.91617821
100MP0001986_abnormal_taste_sensitivity0.91101621
101MP0000013_abnormal_adipose_tissue0.90575675
102MP0001944_abnormal_pancreas_morphology0.89779338
103MP0003806_abnormal_nucleotide_metabolis0.89033486
104MP0008874_decreased_physiological_sensi0.88577337
105MP0003632_abnormal_nervous_system0.87685383
106MP0002152_abnormal_brain_morphology0.86636725
107MP0002751_abnormal_autonomic_nervous0.86029111
108MP0004085_abnormal_heartbeat0.85276412
109MP0002234_abnormal_pharynx_morphology0.84897302
110MP0005535_abnormal_body_temperature0.83389531
111MP0000026_abnormal_inner_ear0.83388860
112MP0000631_abnormal_neuroendocrine_gland0.82086792
113MP0000751_myopathy0.81175886
114MP0004147_increased_porphyrin_level0.81077622
115MP0000566_synostosis0.80446620
116MP0000639_abnormal_adrenal_gland0.79807562
117MP0003787_abnormal_imprinting0.79806391
118MP0009697_abnormal_copulation0.78629688
119MP0002332_abnormal_exercise_endurance0.77537354
120MP0002069_abnormal_eating/drinking_beha0.77402337
121MP0006072_abnormal_retinal_apoptosis0.76425866
122MP0005645_abnormal_hypothalamus_physiol0.75835526
123MP0006292_abnormal_olfactory_placode0.75511797
124MP0004484_altered_response_of0.74565214
125MP0005394_taste/olfaction_phenotype0.73622324
126MP0005499_abnormal_olfactory_system0.73622324
127MP0002909_abnormal_adrenal_gland0.73338749
128MP0001177_atelectasis0.72643550
129MP0004215_abnormal_myocardial_fiber0.69274486
130MP0008260_abnormal_autophagy0.69068065
131MP0004036_abnormal_muscle_relaxation0.65497021
132MP0002090_abnormal_vision0.65071709
133MP0003938_abnormal_ear_development0.64244106
134MP0005595_abnormal_vascular_smooth0.62502535
135MP0001348_abnormal_lacrimal_gland0.62329427
136MP0005379_endocrine/exocrine_gland_phen0.61491779
137MP0005623_abnormal_meninges_morphology0.59364603
138MP0005195_abnormal_posterior_eye0.58988008

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.25462085
2Myokymia (HP:0002411)4.74652231
3Epileptic encephalopathy (HP:0200134)4.65057340
4Atonic seizures (HP:0010819)4.59756308
5Acute necrotizing encephalopathy (HP:0006965)4.36197814
6Focal seizures (HP:0007359)4.07919782
7Neurofibrillary tangles (HP:0002185)3.90409763
8Hyperventilation (HP:0002883)3.89186028
9Abnormal mitochondria in muscle tissue (HP:0008316)3.88555424
10Progressive macrocephaly (HP:0004481)3.74746982
11Degeneration of the lateral corticospinal tracts (HP:0002314)3.69781833
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.69781833
13Cerebral inclusion bodies (HP:0100314)3.66125330
14Mitochondrial inheritance (HP:0001427)3.56604017
15Acute encephalopathy (HP:0006846)3.54844519
16Absence seizures (HP:0002121)3.43550465
17Absent/shortened dynein arms (HP:0200106)3.40174243
18Dynein arm defect of respiratory motile cilia (HP:0012255)3.40174243
19Dialeptic seizures (HP:0011146)3.39270583
20Febrile seizures (HP:0002373)3.36981761
21Scanning speech (HP:0002168)3.26494506
22Visual hallucinations (HP:0002367)3.20776092
23Increased serum pyruvate (HP:0003542)3.10983436
24Abnormality of glycolysis (HP:0004366)3.10983436
25Abnormality of the corticospinal tract (HP:0002492)3.02384505
26Hepatocellular necrosis (HP:0001404)3.00317434
27Medial flaring of the eyebrow (HP:0010747)2.95659679
28True hermaphroditism (HP:0010459)2.94082576
29Generalized tonic-clonic seizures (HP:0002069)2.93129647
30Pancreatic cysts (HP:0001737)2.92771434
31Increased CSF lactate (HP:0002490)2.92687544
32Progressive cerebellar ataxia (HP:0002073)2.89638442
33Pancreatic fibrosis (HP:0100732)2.88388022
34Gait imbalance (HP:0002141)2.86740680
35Pheochromocytoma (HP:0002666)2.84943867
36Leukodystrophy (HP:0002415)2.82382724
37Retinal dysplasia (HP:0007973)2.81591745
38Molar tooth sign on MRI (HP:0002419)2.80321061
39Abnormality of midbrain morphology (HP:0002418)2.80321061
40Termporal pattern (HP:0011008)2.79310402
41Insidious onset (HP:0003587)2.79310402
42Sensory axonal neuropathy (HP:0003390)2.78152859
43Supranuclear gaze palsy (HP:0000605)2.75143656
44Methylmalonic acidemia (HP:0002912)2.71265903
45Congenital primary aphakia (HP:0007707)2.68729841
46Dysmetria (HP:0001310)2.66138001
47Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65169148
48Neuroendocrine neoplasm (HP:0100634)2.63693359
49Optic disc pallor (HP:0000543)2.60811484
503-Methylglutaconic aciduria (HP:0003535)2.59669475
51Broad-based gait (HP:0002136)2.59368973
52Abnormal ciliary motility (HP:0012262)2.54454057
53Diplopia (HP:0000651)2.52331433
54Abnormality of binocular vision (HP:0011514)2.52331433
55Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50583959
56Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50583959
57Truncal ataxia (HP:0002078)2.49768834
58Gaze-evoked nystagmus (HP:0000640)2.48254357
59Hypoglycemic coma (HP:0001325)2.47839884
60Nephronophthisis (HP:0000090)2.46282256
61Abnormality of urine glucose concentration (HP:0011016)2.45393755
62Glycosuria (HP:0003076)2.45393755
63Amblyopia (HP:0000646)2.44447411
64Nephrogenic diabetes insipidus (HP:0009806)2.42738288
65Renal Fanconi syndrome (HP:0001994)2.40600893
66Limb dystonia (HP:0002451)2.39247239
67Increased hepatocellular lipid droplets (HP:0006565)2.37061094
68Genital tract atresia (HP:0001827)2.36994752
69Anxiety (HP:0000739)2.36854676
70Vaginal atresia (HP:0000148)2.34002502
71Abnormal hair whorl (HP:0010721)2.33044237
72Poor suck (HP:0002033)2.32773188
73Spastic gait (HP:0002064)2.28115844
74Delusions (HP:0000746)2.26865602
75Cerebral edema (HP:0002181)2.26032034
76Hemiparesis (HP:0001269)2.24159404
77Increased intramyocellular lipid droplets (HP:0012240)2.19008562
78Abnormal respiratory motile cilium morphology (HP:0005938)2.17721700
79Abnormal respiratory epithelium morphology (HP:0012253)2.17721700
80Peripheral hypomyelination (HP:0007182)2.17321081
81Abnormality of renal resorption (HP:0011038)2.15911314
82X-linked dominant inheritance (HP:0001423)2.15033201
83Methylmalonic aciduria (HP:0012120)2.14258034
84Abnormal eating behavior (HP:0100738)2.13018912
85Abnormality of the labia minora (HP:0012880)2.12172952
86Dysdiadochokinesis (HP:0002075)2.12076508
87Hepatic necrosis (HP:0002605)2.11910249
88Drooling (HP:0002307)2.10098737
89Excessive salivation (HP:0003781)2.10098737
90Inability to walk (HP:0002540)2.10075890
91Progressive inability to walk (HP:0002505)2.09217875
92Increased serum lactate (HP:0002151)2.08448114
93Generalized aminoaciduria (HP:0002909)2.07089119
94Specific learning disability (HP:0001328)2.06840083
95Respiratory failure (HP:0002878)2.06195925
96Hypoglycemic seizures (HP:0002173)2.05445074
97Aplasia/hypoplasia of the uterus (HP:0008684)2.04527627
98Aplasia of the phalanges of the hand (HP:0009802)2.03739796
99Aplasia involving bones of the extremities (HP:0009825)2.03739796
100Aplasia involving bones of the upper limbs (HP:0009823)2.03739796
101Autoamputation (HP:0001218)2.03411029
102Abnormal respiratory motile cilium physiology (HP:0012261)2.03177853
103Thickened helices (HP:0000391)2.02854851
104Impaired vibration sensation in the lower limbs (HP:0002166)2.02666326
105Short tibia (HP:0005736)2.01430563
106Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.01211452
107Hypsarrhythmia (HP:0002521)2.01108241
108Epileptiform EEG discharges (HP:0011182)2.01058871
109Polyphagia (HP:0002591)2.00139428
110Abnormality of the renal medulla (HP:0100957)1.99544415
111Lipid accumulation in hepatocytes (HP:0006561)1.99457210
112Lower limb muscle weakness (HP:0007340)1.99392258
113Male pseudohermaphroditism (HP:0000037)1.99027236
114Renal cortical cysts (HP:0000803)1.98277636
115Hyperinsulinemic hypoglycemia (HP:0000825)1.98274104
116Poor eye contact (HP:0000817)1.98252781
117Muscular hypotonia of the trunk (HP:0008936)1.97848412
118Abnormality of the renal cortex (HP:0011035)1.97246986
119Hypothermia (HP:0002045)1.95455556
120Ketoacidosis (HP:0001993)1.95402309
121Generalized myoclonic seizures (HP:0002123)1.95268883
122Sclerocornea (HP:0000647)1.94600863
123Abnormality of vitamin B metabolism (HP:0004340)1.92834807
124Exertional dyspnea (HP:0002875)1.92650260
125Exercise intolerance (HP:0003546)1.92322416
126Psychosis (HP:0000709)1.91988570
127Intestinal atresia (HP:0011100)1.91762718
128Type II lissencephaly (HP:0007260)1.91714494
129Action tremor (HP:0002345)1.91332895
130Ankle clonus (HP:0011448)1.91314678
131Lethargy (HP:0001254)1.90162827
132Lactic acidosis (HP:0003128)1.89605214
133Adrenal hypoplasia (HP:0000835)1.89425107
134Hyperphosphaturia (HP:0003109)1.89359719
135Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84940475
136Cerebral hemorrhage (HP:0001342)1.84152401
137Aplasia/Hypoplasia of the tibia (HP:0005772)1.84135335
138Poor coordination (HP:0002370)1.84026669
139Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82558103
140Large for gestational age (HP:0001520)1.81652931
141Degeneration of anterior horn cells (HP:0002398)1.81027666
142Abnormality of the anterior horn cell (HP:0006802)1.81027666
143Postaxial hand polydactyly (HP:0001162)1.80915365
144Urinary bladder sphincter dysfunction (HP:0002839)1.80435101
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.78341061
146EEG with generalized epileptiform discharges (HP:0011198)1.77782020
147Congenital, generalized hypertrichosis (HP:0004540)1.77472518
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.77000100
149Aplasia/Hypoplasia of the lens (HP:0008063)1.76291175
150Rhinitis (HP:0012384)1.76037675
151Agitation (HP:0000713)1.73593494
152Lissencephaly (HP:0001339)1.73407299

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.63892199
2EPHA44.15115332
3MAP3K123.06558350
4NTRK32.96657302
5WNK32.89314860
6FRK2.69736426
7MAP4K22.59909723
8MAP3K42.59620950
9MAP2K72.56837872
10OXSR12.38103845
11CDK192.35760616
12TRIM282.31163845
13PLK22.20446542
14RIPK42.08163205
15STK392.03219541
16PNCK1.83864857
17ARAF1.81640519
18GRK51.80643887
19BCR1.73939785
20NME11.73780561
21MINK11.72103935
22MAP3K91.71316461
23PINK11.68095358
24PRPF4B1.63645426
25TNIK1.57652235
26ERBB31.52318795
27DYRK21.50980994
28FGR1.49439927
29BMPR21.49012687
30DAPK21.44506985
31CAMK2A1.38286640
32MAP2K41.38220645
33CAMK2B1.37962258
34MAPKAPK51.37913088
35MUSK1.36402620
36MAPK131.34154383
37PTK2B1.33290571
38NTRK11.32690751
39DAPK11.30181569
40GRK11.28651920
41TESK11.27380348
42SGK2231.25778225
43SGK4941.25778225
44SIK31.23370743
45NEK11.22270101
46EIF2AK11.20807018
47MARK11.20293204
48CDK51.19016714
49EIF2AK31.18624355
50VRK11.17049625
51NTRK21.14233492
52MAP3K131.12462989
53INSRR1.11852028
54KSR21.11628538
55PAK61.11315824
56AKT31.10070003
57MYLK1.07924494
58VRK21.04567276
59PRKCG1.03262926
60BMPR1B1.02697819
61KSR11.02268118
62CCNB11.02013916
63PLK31.00247061
64UHMK10.99291317
65CAMK2D0.97008010
66ZAK0.96865256
67ADRBK20.94850450
68GRK70.94609924
69PRKCE0.94242465
70MST40.93963308
71CSNK1G20.92102207
72WEE10.89080889
73FES0.89073511
74WNK40.88295082
75PKN10.87298516
76NEK60.86376022
77MAPK150.86335353
78NUAK10.85528441
79BUB10.85421040
80CDK140.85128360
81CAMKK20.85109027
82ROCK20.85041928
83BCKDK0.84564007
84CSNK1G30.84164048
85CDK180.83766020
86CAMK2G0.83532838
87MKNK20.83030632
88LMTK20.82651845
89BRAF0.82546730
90FGFR20.82111389
91SRPK10.80857952
92CDK150.76695259
93STK38L0.72320153
94ADRBK10.69354378
95CDK11A0.67429338
96GRK60.66567972
97TLK10.63916222
98DAPK30.63126866
99SGK20.59935653
100LIMK10.59534335
101MAPK120.59287773
102DYRK1A0.58321477
103PRKCI0.58320140
104PAK30.58278903
105WNK10.57385282
106CSNK1A10.55545200
107PRKACA0.53871119
108CSNK1A1L0.53736005
109CSNK1G10.52033985
110MAP3K20.51995034
111PHKG10.51518210
112PHKG20.51518210
113STK160.51409926
114PLK10.51139345
115PRKD30.50517546
116CDK30.50073424
117SGK10.49857472
118RAF10.49083448
119PBK0.48314831
120BRSK10.47680544
121CAMK10.45161725
122BRSK20.44601922
123CSNK1E0.44291508
124FER0.42719113
125PDK20.42661613
126EPHB20.41891631
127TSSK60.41655150
128CSNK1D0.41395708
129PIK3CA0.40945265
130TNK20.38823352
131PRKCH0.37959142
132MAP2K10.37914396
133PRKG10.37573490
134PRKCA0.36485585
135DYRK30.36344618
136PDPK10.35691931
137PRKACB0.35396082
138MKNK10.35061919
139PRKCQ0.34405411
140CSNK2A20.33198919
141MOS0.32942666
142FYN0.31809517

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.67252238
2Oxidative phosphorylation_Homo sapiens_hsa001903.63937274
3Collecting duct acid secretion_Homo sapiens_hsa049662.86922167
4Synaptic vesicle cycle_Homo sapiens_hsa047212.83759557
5Parkinsons disease_Homo sapiens_hsa050122.79055667
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.66683344
7Alzheimers disease_Homo sapiens_hsa050102.55772554
8GABAergic synapse_Homo sapiens_hsa047272.47905125
9Morphine addiction_Homo sapiens_hsa050322.36147357
10Glutamatergic synapse_Homo sapiens_hsa047242.29702700
11Proteasome_Homo sapiens_hsa030502.28929871
12Circadian entrainment_Homo sapiens_hsa047132.27270506
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.13334932
14Amphetamine addiction_Homo sapiens_hsa050312.12555347
15Long-term potentiation_Homo sapiens_hsa047202.03987691
16Serotonergic synapse_Homo sapiens_hsa047261.97613513
17Salivary secretion_Homo sapiens_hsa049701.89520351
18Taste transduction_Homo sapiens_hsa047421.88371601
19Huntingtons disease_Homo sapiens_hsa050161.83161366
20Olfactory transduction_Homo sapiens_hsa047401.82174456
21Cardiac muscle contraction_Homo sapiens_hsa042601.81541587
22Dopaminergic synapse_Homo sapiens_hsa047281.81116286
23Folate biosynthesis_Homo sapiens_hsa007901.79791786
24Vibrio cholerae infection_Homo sapiens_hsa051101.70968205
25Fatty acid elongation_Homo sapiens_hsa000621.68935599
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.68219018
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.67309819
28Renin secretion_Homo sapiens_hsa049241.65661289
29RNA polymerase_Homo sapiens_hsa030201.62761373
30Long-term depression_Homo sapiens_hsa047301.59113068
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.54165266
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.51034069
33Cocaine addiction_Homo sapiens_hsa050301.45400165
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.44156812
35Calcium signaling pathway_Homo sapiens_hsa040201.42652076
36Insulin secretion_Homo sapiens_hsa049111.41862565
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.40809953
38Propanoate metabolism_Homo sapiens_hsa006401.40637442
39Vitamin B6 metabolism_Homo sapiens_hsa007501.39933013
40Gastric acid secretion_Homo sapiens_hsa049711.39857145
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.36480152
42Cholinergic synapse_Homo sapiens_hsa047251.31743544
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25007210
44Peroxisome_Homo sapiens_hsa041461.23340246
45Phototransduction_Homo sapiens_hsa047441.23209353
46Oxytocin signaling pathway_Homo sapiens_hsa049211.18475884
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.17734613
48Basal transcription factors_Homo sapiens_hsa030221.16284353
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15011369
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.14739000
51Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13936552
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.11880566
53Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.11329559
54Steroid biosynthesis_Homo sapiens_hsa001001.09846851
55Chemical carcinogenesis_Homo sapiens_hsa052041.08778512
56Axon guidance_Homo sapiens_hsa043601.07157925
57Aldosterone synthesis and secretion_Homo sapiens_hsa049251.06702383
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04098907
59Ether lipid metabolism_Homo sapiens_hsa005651.03518361
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.02298959
61Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.01918970
62Tryptophan metabolism_Homo sapiens_hsa003801.01484849
63Ribosome_Homo sapiens_hsa030100.99969003
64Caffeine metabolism_Homo sapiens_hsa002320.96523383
65Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.96302715
66Rheumatoid arthritis_Homo sapiens_hsa053230.96095833
67Nitrogen metabolism_Homo sapiens_hsa009100.95989563
68Gap junction_Homo sapiens_hsa045400.95786631
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.93561367
70cAMP signaling pathway_Homo sapiens_hsa040240.89976337
71Glutathione metabolism_Homo sapiens_hsa004800.89078968
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.88260265
73Retinol metabolism_Homo sapiens_hsa008300.87037740
74Pyruvate metabolism_Homo sapiens_hsa006200.86928441
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.85495005
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.83729568
77GnRH signaling pathway_Homo sapiens_hsa049120.83154115
78Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82497473
79Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.82475791
80Protein export_Homo sapiens_hsa030600.81584656
81Selenocompound metabolism_Homo sapiens_hsa004500.78970586
82RNA degradation_Homo sapiens_hsa030180.74613920
83beta-Alanine metabolism_Homo sapiens_hsa004100.74296773
84Homologous recombination_Homo sapiens_hsa034400.74275503
85Linoleic acid metabolism_Homo sapiens_hsa005910.72040103
86Melanogenesis_Homo sapiens_hsa049160.70714089
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69564165
88Sulfur metabolism_Homo sapiens_hsa009200.69034069
89Pancreatic secretion_Homo sapiens_hsa049720.68653234
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66791731
91Pyrimidine metabolism_Homo sapiens_hsa002400.66462328
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66394145
93Purine metabolism_Homo sapiens_hsa002300.65644385
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65407689
95Mismatch repair_Homo sapiens_hsa034300.62146521
96Nucleotide excision repair_Homo sapiens_hsa034200.60286120
97Fanconi anemia pathway_Homo sapiens_hsa034600.60150250
98Fatty acid metabolism_Homo sapiens_hsa012120.59320531
99Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58513203
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.55881483
101Arginine and proline metabolism_Homo sapiens_hsa003300.54322497
102Butanoate metabolism_Homo sapiens_hsa006500.54147487
103Sulfur relay system_Homo sapiens_hsa041220.53260431
104Phagosome_Homo sapiens_hsa041450.53241626
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.52301248
106Fatty acid degradation_Homo sapiens_hsa000710.51132498
107Estrogen signaling pathway_Homo sapiens_hsa049150.51091225
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50754874
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.50726092
110Phenylalanine metabolism_Homo sapiens_hsa003600.50170962
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49915003
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49043306
113Sphingolipid metabolism_Homo sapiens_hsa006000.48804753
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.48710330
115Ras signaling pathway_Homo sapiens_hsa040140.47551886
116Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46004364
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45726507
118ErbB signaling pathway_Homo sapiens_hsa040120.45209681
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44731617
120Histidine metabolism_Homo sapiens_hsa003400.42945882
121Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.42923017
122African trypanosomiasis_Homo sapiens_hsa051430.42743933
123Dilated cardiomyopathy_Homo sapiens_hsa054140.40150585
124Fat digestion and absorption_Homo sapiens_hsa049750.39862076
125N-Glycan biosynthesis_Homo sapiens_hsa005100.39332448
126Arginine biosynthesis_Homo sapiens_hsa002200.38887303
127Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37303797
128Dorso-ventral axis formation_Homo sapiens_hsa043200.37050900
129Thyroid hormone synthesis_Homo sapiens_hsa049180.36693455
130MAPK signaling pathway_Homo sapiens_hsa040100.35363427
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.35075204
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.34286556
133Alcoholism_Homo sapiens_hsa050340.33534571
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.32996249
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31994032
136Oocyte meiosis_Homo sapiens_hsa041140.31166875
137Ovarian steroidogenesis_Homo sapiens_hsa049130.30139408
138Metabolic pathways_Homo sapiens_hsa011000.29983416
139Prion diseases_Homo sapiens_hsa050200.28911818
140Tyrosine metabolism_Homo sapiens_hsa003500.28523967
141Fatty acid biosynthesis_Homo sapiens_hsa000610.28191123
142Regulation of autophagy_Homo sapiens_hsa041400.28144310
143Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27802366
144Mineral absorption_Homo sapiens_hsa049780.26239612
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.24934335
146Rap1 signaling pathway_Homo sapiens_hsa040150.24488453
147Circadian rhythm_Homo sapiens_hsa047100.23609673
148Choline metabolism in cancer_Homo sapiens_hsa052310.22966669

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