TMEM14B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.34935259
2proteasome assembly (GO:0043248)5.64677963
3ATP synthesis coupled proton transport (GO:0015986)5.55971862
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.55971862
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.98534824
6establishment of protein localization to mitochondrial membrane (GO:0090151)4.83478580
7respiratory electron transport chain (GO:0022904)4.73791870
8electron transport chain (GO:0022900)4.66372376
9protein complex biogenesis (GO:0070271)4.37110599
10negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.31415425
11chaperone-mediated protein transport (GO:0072321)4.30840536
12mitochondrial respiratory chain complex assembly (GO:0033108)4.24975217
13regulation of mitochondrial translation (GO:0070129)4.13983846
14regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05643244
15positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.04973186
16mitochondrial respiratory chain complex I assembly (GO:0032981)4.02432139
17NADH dehydrogenase complex assembly (GO:0010257)4.02432139
18mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.02432139
19anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.94024292
20CENP-A containing nucleosome assembly (GO:0034080)3.91672165
21respiratory chain complex IV assembly (GO:0008535)3.91644124
22cullin deneddylation (GO:0010388)3.88774472
23negative regulation of ligase activity (GO:0051352)3.88717853
24negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.88717853
25chromatin remodeling at centromere (GO:0031055)3.88021561
26protein neddylation (GO:0045116)3.79029638
27regulation of cellular amino acid metabolic process (GO:0006521)3.76408445
28ribosomal small subunit assembly (GO:0000028)3.72241473
29cytochrome complex assembly (GO:0017004)3.66619865
30establishment of integrated proviral latency (GO:0075713)3.65150569
31transcription elongation from RNA polymerase III promoter (GO:0006385)3.64300233
32termination of RNA polymerase III transcription (GO:0006386)3.64300233
33protein deneddylation (GO:0000338)3.64050304
34DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.63657961
35nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.62267634
36rRNA modification (GO:0000154)3.62200200
37exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59175435
38signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.57725059
39signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.57725059
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.57725059
41signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.55859526
42intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.55859526
43oxidative phosphorylation (GO:0006119)3.54343168
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.54311942
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.54311942
46positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.51111708
47protein targeting to mitochondrion (GO:0006626)3.48512299
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.43373047
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.43373047
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.39729758
51telomere maintenance via semi-conservative replication (GO:0032201)3.38793224
52positive regulation of ligase activity (GO:0051351)3.37278815
53pseudouridine synthesis (GO:0001522)3.29980273
54ATP biosynthetic process (GO:0006754)3.29593317
55ribosomal large subunit biogenesis (GO:0042273)3.27845524
56purine nucleoside triphosphate biosynthetic process (GO:0009145)3.26262668
57protein localization to mitochondrion (GO:0070585)3.25955715
58establishment of protein localization to mitochondrion (GO:0072655)3.25830663
59SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.25159396
60cotranslational protein targeting to membrane (GO:0006613)3.23991695
61histone exchange (GO:0043486)3.22564382
62translation (GO:0006412)3.21613994
63purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.20732774
64protein targeting to ER (GO:0045047)3.17520788
65spliceosomal snRNP assembly (GO:0000387)3.15338511
66translational termination (GO:0006415)3.14568882
67viral transcription (GO:0019083)3.13432642
68regulation of ubiquitin-protein transferase activity (GO:0051438)3.11342561
69DNA strand elongation involved in DNA replication (GO:0006271)3.10488664
70DNA replication checkpoint (GO:0000076)3.06768257
71establishment of protein localization to endoplasmic reticulum (GO:0072599)3.05287546
72protein localization to endoplasmic reticulum (GO:0070972)3.05174777
73regulation of mitotic spindle checkpoint (GO:1903504)3.04055335
74regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.04055335
75DNA deamination (GO:0045006)3.03000931
76protein-cofactor linkage (GO:0018065)3.02695558
77hydrogen ion transmembrane transport (GO:1902600)3.02132202
78regulation of ligase activity (GO:0051340)3.01436510
79inner mitochondrial membrane organization (GO:0007007)2.99539444
80purine nucleobase biosynthetic process (GO:0009113)2.95325363
81DNA strand elongation (GO:0022616)2.95284382
82cellular component biogenesis (GO:0044085)2.95199984
83establishment of viral latency (GO:0019043)2.95181361
84rRNA methylation (GO:0031167)2.93046611
85GTP biosynthetic process (GO:0006183)2.92674389
86mitochondrial transport (GO:0006839)2.92383742
87transcription-coupled nucleotide-excision repair (GO:0006283)2.91923355
88DNA catabolic process, exonucleolytic (GO:0000738)2.91488716
89telomere maintenance via recombination (GO:0000722)2.90922140
90DNA double-strand break processing (GO:0000729)2.90177091
91ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90017209
92maturation of SSU-rRNA (GO:0030490)2.85193556
93DNA damage response, detection of DNA damage (GO:0042769)2.84457034
94nucleotide-excision repair, DNA gap filling (GO:0006297)2.84305878
95rRNA processing (GO:0006364)2.83804245
96translational initiation (GO:0006413)2.82353380
97DNA replication-independent nucleosome organization (GO:0034724)2.80918343
98DNA replication-independent nucleosome assembly (GO:0006336)2.80918343
99mitotic recombination (GO:0006312)2.80859373
100deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80761993

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.39912076
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.69846532
3EST1_17652178_ChIP-ChIP_JURKAT_Human4.29342471
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.18817785
5E2F7_22180533_ChIP-Seq_HELA_Human4.02198631
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.58096730
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.37668292
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34285928
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.24693774
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15598223
11HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.14783434
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.06043648
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03354981
14ELK1_19687146_ChIP-ChIP_HELA_Human2.89458482
15* VDR_23849224_ChIP-Seq_CD4+_Human2.70996297
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.67122640
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.52249077
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.52093890
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.49494783
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.47856848
21SRF_21415370_ChIP-Seq_HL-1_Mouse2.43376202
22FOXP3_21729870_ChIP-Seq_TREG_Human2.42206124
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.27961879
24DCP1A_22483619_ChIP-Seq_HELA_Human2.19315839
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.16173790
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.12185074
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09655646
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07076891
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04269247
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.02871715
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.01964213
32FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97986681
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.96901350
34GABP_19822575_ChIP-Seq_HepG2_Human1.89424180
35NELFA_20434984_ChIP-Seq_ESCs_Mouse1.87518419
36* TTF2_22483619_ChIP-Seq_HELA_Human1.86815074
37* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.85318426
38MYC_18940864_ChIP-ChIP_HL60_Human1.77994989
39XRN2_22483619_ChIP-Seq_HELA_Human1.76149456
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.74365838
41ZNF274_21170338_ChIP-Seq_K562_Hela1.61862645
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.60805430
43VDR_22108803_ChIP-Seq_LS180_Human1.60578475
44FOXM1_23109430_ChIP-Seq_U2OS_Human1.58193269
45CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.53972638
46YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52452118
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.52418748
48YY1_21170310_ChIP-Seq_MESCs_Mouse1.46557180
49POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42860677
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.39999659
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.38952619
52EWS_26573619_Chip-Seq_HEK293_Human1.38445603
53HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.30980565
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29596558
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.29161472
56AR_21909140_ChIP-Seq_LNCAP_Human1.28574806
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.25923897
58POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23823818
59ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23782478
60FUS_26573619_Chip-Seq_HEK293_Human1.23159411
61ELK1_22589737_ChIP-Seq_MCF10A_Human1.20332744
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.19567008
63KDM5A_27292631_Chip-Seq_BREAST_Human1.15517910
64TP53_22573176_ChIP-Seq_HFKS_Human1.08773943
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05572004
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.04078767
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.02426702
68* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01978460
69IGF1R_20145208_ChIP-Seq_DFB_Human1.01496259
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01043473
71DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99072636
72E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97574328
73IRF1_19129219_ChIP-ChIP_H3396_Human0.97523277
74NANOG_18555785_ChIP-Seq_MESCs_Mouse0.94925546
75ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93387944
76SOX2_16153702_ChIP-ChIP_HESCs_Human0.93107914
77POU3F2_20337985_ChIP-ChIP_501MEL_Human0.92963515
78ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92699966
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90494920
80FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.88965909
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.88727319
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.87498041
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.87314128
84CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85858790
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.84223129
86SALL1_21062744_ChIP-ChIP_HESCs_Human0.81843363
87NOTCH1_21737748_ChIP-Seq_TLL_Human0.80060548
88HTT_18923047_ChIP-ChIP_STHdh_Human0.80031143
89FOXA1_27270436_Chip-Seq_PROSTATE_Human0.79321678
90FOXA1_25329375_ChIP-Seq_VCAP_Human0.79321678
91MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76802510
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.76645908
93SOX2_18555785_ChIP-Seq_MESCs_Mouse0.74152131
94AR_20517297_ChIP-Seq_VCAP_Human0.73848794
95P300_19829295_ChIP-Seq_ESCs_Human0.72110106
96PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71013812
97* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.70970778
98GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.70847217
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70665662
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.70106881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.93553032
2MP0003806_abnormal_nucleotide_metabolis3.48685981
3MP0003693_abnormal_embryo_hatching3.36156796
4MP0004147_increased_porphyrin_level3.24953842
5MP0010094_abnormal_chromosome_stability3.18847798
6MP0003718_maternal_effect2.89284839
7MP0003186_abnormal_redox_activity2.87813453
8MP0000372_irregular_coat_pigmentation2.80900077
9MP0004957_abnormal_blastocyst_morpholog2.72932264
10MP0006036_abnormal_mitochondrial_physio2.61924782
11MP0006292_abnormal_olfactory_placode2.49762579
12MP0008877_abnormal_DNA_methylation2.39163200
13MP0009697_abnormal_copulation2.33251111
14MP0003111_abnormal_nucleus_morphology2.31630352
15MP0003077_abnormal_cell_cycle2.24971287
16MP0003786_premature_aging2.20072996
17MP0006072_abnormal_retinal_apoptosis2.16162458
18MP0003136_yellow_coat_color2.12862357
19MP0001529_abnormal_vocalization2.10796863
20MP0008932_abnormal_embryonic_tissue2.07665654
21MP0002938_white_spotting2.01446945
22MP0002102_abnormal_ear_morphology1.99855115
23MP0006035_abnormal_mitochondrial_morpho1.96733957
24MP0008057_abnormal_DNA_replication1.85887278
25MP0005084_abnormal_gallbladder_morpholo1.84895732
26MP0008007_abnormal_cellular_replicative1.80602876
27MP0002837_dystrophic_cardiac_calcinosis1.75474819
28MP0009379_abnormal_foot_pigmentation1.70368789
29MP0008789_abnormal_olfactory_epithelium1.68373697
30MP0008875_abnormal_xenobiotic_pharmacok1.61621433
31MP0008995_early_reproductive_senescence1.61337245
32MP0005075_abnormal_melanosome_morpholog1.57631638
33MP0003195_calcinosis1.57399370
34MP0005408_hypopigmentation1.56374226
35MP0001293_anophthalmia1.54134328
36MP0001764_abnormal_homeostasis1.49336514
37MP0001984_abnormal_olfaction1.47362099
38MP0002736_abnormal_nociception_after1.42290839
39MP0010030_abnormal_orbit_morphology1.40291711
40MP0005253_abnormal_eye_physiology1.33730709
41MP0003011_delayed_dark_adaptation1.29900193
42MP0002210_abnormal_sex_determination1.29670071
43MP0003890_abnormal_embryonic-extraembry1.28038439
44MP0001929_abnormal_gametogenesis1.27949720
45MP0000358_abnormal_cell_content/1.25317446
46MP0005551_abnormal_eye_electrophysiolog1.25306311
47MP0005394_taste/olfaction_phenotype1.20963175
48MP0005499_abnormal_olfactory_system1.20963175
49MP0002160_abnormal_reproductive_system1.15267602
50MP0002095_abnormal_skin_pigmentation1.13416769
51MP0004142_abnormal_muscle_tone1.12379048
52MP0008872_abnormal_physiological_respon1.10948465
53MP0003567_abnormal_fetal_cardiomyocyte1.08430766
54MP0004133_heterotaxia1.06390322
55MP0000653_abnormal_sex_gland1.04119063
56MP0002638_abnormal_pupillary_reflex1.02263300
57MP0004215_abnormal_myocardial_fiber1.02114209
58MP0005645_abnormal_hypothalamus_physiol1.01635776
59MP0002234_abnormal_pharynx_morphology1.01319096
60MP0002653_abnormal_ependyma_morphology0.99848023
61MP0005332_abnormal_amino_acid0.99801050
62MP0001145_abnormal_male_reproductive0.99675558
63MP0002277_abnormal_respiratory_mucosa0.98702611
64MP0005410_abnormal_fertilization0.96113250
65MP0005636_abnormal_mineral_homeostasis0.95079772
66MP0002090_abnormal_vision0.93279587
67MP0000647_abnormal_sebaceous_gland0.91696489
68MP0004145_abnormal_muscle_electrophysio0.91551151
69MP0000631_abnormal_neuroendocrine_gland0.90642853
70MP0005389_reproductive_system_phenotype0.90141576
71MP0001905_abnormal_dopamine_level0.89622852
72MP0009046_muscle_twitch0.89089588
73MP0003698_abnormal_male_reproductive0.88692341
74MP0003880_abnormal_central_pattern0.86049474
75MP0005083_abnormal_biliary_tract0.85933244
76MP0003950_abnormal_plasma_membrane0.84140564
77MP0002163_abnormal_gland_morphology0.84056429
78MP0005395_other_phenotype0.83054408
79MP0001968_abnormal_touch/_nociception0.82773506
80MP0006276_abnormal_autonomic_nervous0.82055783
81MP0003121_genomic_imprinting0.81161773
82MP0003646_muscle_fatigue0.80426999
83MP0005646_abnormal_pituitary_gland0.76729651
84MP0003656_abnormal_erythrocyte_physiolo0.76697312
85MP0005379_endocrine/exocrine_gland_phen0.76550430
86MP0001697_abnormal_embryo_size0.75819276
87MP0003137_abnormal_impulse_conducting0.75717107
88MP0001324_abnormal_eye_pigmentation0.75239613
89MP0001119_abnormal_female_reproductive0.74026447
90MP0000749_muscle_degeneration0.73172181
91MP0003937_abnormal_limbs/digits/tail_de0.72906349
92MP0001485_abnormal_pinna_reflex0.72258532
93MP0000350_abnormal_cell_proliferation0.71530028
94MP0005174_abnormal_tail_pigmentation0.70819996
95MP0001286_abnormal_eye_development0.69919880
96MP0000313_abnormal_cell_death0.69070884
97MP0005266_abnormal_metabolism0.68307649
98MP0002132_abnormal_respiratory_system0.68082072
99MP0002233_abnormal_nose_morphology0.67739474
100MP0002751_abnormal_autonomic_nervous0.65799523

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.51785615
2Abnormal mitochondria in muscle tissue (HP:0008316)5.08887226
3Acute encephalopathy (HP:0006846)5.01948081
4Mitochondrial inheritance (HP:0001427)4.85249435
5Progressive macrocephaly (HP:0004481)4.67640138
6Increased CSF lactate (HP:0002490)4.57668530
7Increased hepatocellular lipid droplets (HP:0006565)4.34448968
8Hepatocellular necrosis (HP:0001404)4.25924394
9Hepatic necrosis (HP:0002605)4.14549492
10Lipid accumulation in hepatocytes (HP:0006561)4.07485966
11Cerebral edema (HP:0002181)3.74451801
12Renal Fanconi syndrome (HP:0001994)3.59692085
13Abnormal number of erythroid precursors (HP:0012131)3.14274860
14Increased intramyocellular lipid droplets (HP:0012240)3.14179104
15Increased serum lactate (HP:0002151)3.10799217
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.10107179
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.10107179
18Lactic acidosis (HP:0003128)3.09692312
193-Methylglutaconic aciduria (HP:0003535)3.03364078
20Abnormality of cells of the erythroid lineage (HP:0012130)2.94733965
21Type I transferrin isoform profile (HP:0003642)2.93843228
22Respiratory failure (HP:0002878)2.88610364
23Exercise intolerance (HP:0003546)2.78839824
24Optic disc pallor (HP:0000543)2.71771912
25Exertional dyspnea (HP:0002875)2.69708339
26Pancreatic cysts (HP:0001737)2.65272226
27Increased muscle lipid content (HP:0009058)2.64799020
28Pancreatic fibrosis (HP:0100732)2.60339845
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60299020
30Reticulocytopenia (HP:0001896)2.53569191
31Increased serum pyruvate (HP:0003542)2.49040413
32Lethargy (HP:0001254)2.48926964
33Macrocytic anemia (HP:0001972)2.47669421
34Leukodystrophy (HP:0002415)2.47419113
35Respiratory difficulties (HP:0002880)2.45547191
36True hermaphroditism (HP:0010459)2.44979364
37Methylmalonic acidemia (HP:0002912)2.44395832
38Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.42824533
39Abnormal protein N-linked glycosylation (HP:0012347)2.42824533
40Abnormal protein glycosylation (HP:0012346)2.42824533
41Abnormal glycosylation (HP:0012345)2.42824533
42Molar tooth sign on MRI (HP:0002419)2.40629602
43Abnormality of midbrain morphology (HP:0002418)2.40629602
44Abnormality of alanine metabolism (HP:0010916)2.38377950
45Hyperalaninemia (HP:0003348)2.38377950
46Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38377950
47Abnormality of renal resorption (HP:0011038)2.36226797
48Meckel diverticulum (HP:0002245)2.35367393
49Congenital, generalized hypertrichosis (HP:0004540)2.30986603
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.29356573
51Methylmalonic aciduria (HP:0012120)2.27092468
52Abnormality of the ileum (HP:0001549)2.26790075
53Abnormality of methionine metabolism (HP:0010901)2.26038089
54Abnormality of glycolysis (HP:0004366)2.25871553
55Generalized aminoaciduria (HP:0002909)2.23259467
56CNS demyelination (HP:0007305)2.21546949
57Abnormality of urine glucose concentration (HP:0011016)2.18454267
58Glycosuria (HP:0003076)2.18454267
59Degeneration of anterior horn cells (HP:0002398)2.17652438
60Abnormality of the anterior horn cell (HP:0006802)2.17652438
61Medial flaring of the eyebrow (HP:0010747)2.17323684
62Reduced antithrombin III activity (HP:0001976)2.15220543
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.14367395
64Colon cancer (HP:0003003)2.09698748
65Aplastic anemia (HP:0001915)2.08189508
66Abnormality of the preputium (HP:0100587)2.07206426
67Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.06150097
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02805881
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.01658697
70Pancytopenia (HP:0001876)1.98826153
71Abnormality of serum amino acid levels (HP:0003112)1.97598919
72Abnormality of chromosome stability (HP:0003220)1.96192735
73Hyperglycinemia (HP:0002154)1.95326734
74Chromsome breakage (HP:0040012)1.94576469
75Abnormality of the labia minora (HP:0012880)1.94181231
76Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93107989
77Nephronophthisis (HP:0000090)1.92880062
78Sclerocornea (HP:0000647)1.87990724
79X-linked dominant inheritance (HP:0001423)1.87352289
80Oral leukoplakia (HP:0002745)1.86257008
81Abnormality of dicarboxylic acid metabolism (HP:0010995)1.85306963
82Dicarboxylic aciduria (HP:0003215)1.85306963
83Birth length less than 3rd percentile (HP:0003561)1.84713789
84Hypoglycemic coma (HP:0001325)1.84232353
85Pallor (HP:0000980)1.81722852
86Aplasia/Hypoplasia of the tongue (HP:0010295)1.75264286
87Duodenal stenosis (HP:0100867)1.74605412
88Small intestinal stenosis (HP:0012848)1.74605412
89Hyperphosphaturia (HP:0003109)1.72999355
90Aplasia/hypoplasia of the uterus (HP:0008684)1.71843945
91Triphalangeal thumb (HP:0001199)1.71510362
92Nausea (HP:0002018)1.71364948
93Absent thumb (HP:0009777)1.70864314
94Abnormal respiratory motile cilium physiology (HP:0012261)1.68872637
95Microvesicular hepatic steatosis (HP:0001414)1.67561563
96Congenital primary aphakia (HP:0007707)1.67338690
97Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.67306670
98Renal cortical cysts (HP:0000803)1.67074942
99Emotional lability (HP:0000712)1.66404315
100Hyperglycinuria (HP:0003108)1.65868750

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.41226699
2BUB13.67366241
3PBK2.87000757
4MST42.83455943
5ZAK2.71029570
6STK162.60147565
7VRK12.53994412
8EIF2AK12.48120831
9SRPK12.36435935
10CDC72.34684048
11NEK12.20026460
12NUAK12.15723469
13NME22.11092929
14TRIM282.07170278
15NME12.05448785
16BMPR1B1.91435530
17MAP3K121.89432088
18PLK41.83724737
19EIF2AK31.82703781
20MAP4K21.82366354
21PLK31.81609991
22WEE11.81361919
23TTK1.70545960
24PDK21.66398250
25BCKDK1.65587693
26TSSK61.65240951
27WNK31.52186358
28TLK11.50386114
29PLK11.37214486
30BRSK21.30137319
31ACVR1B1.22661000
32FRK1.20983455
33CCNB11.16680049
34INSRR1.04547475
35GRK11.03806115
36MKNK11.03162496
37ADRBK21.02578897
38TAF10.99613569
39LIMK10.99586991
40CSNK1G30.98914818
41AURKB0.98346915
42DYRK20.93697800
43CSNK1G10.91106200
44ERBB40.90965334
45MKNK20.89459370
46TNIK0.88738053
47CSNK1G20.84770305
48CHEK20.83985908
49BRSK10.82681682
50ATR0.82533235
51TESK20.82275178
52AURKA0.79489240
53MAP2K70.78821921
54ERBB30.78742359
55EIF2AK20.76397532
56TESK10.73103214
57RPS6KA50.73101000
58CDK190.72933072
59DAPK10.72649315
60STK40.71189877
61CDK80.70895030
62PLK20.70489249
63CSNK1A1L0.69634218
64MAP3K40.68132476
65PIM20.68093825
66PNCK0.67049260
67MUSK0.63294497
68PINK10.62893578
69CSNK2A20.61945987
70CSNK2A10.61349846
71NEK20.61081940
72KDR0.60349971
73BCR0.60102790
74MYLK0.56545621
75SCYL20.55838555
76PRKCI0.55637057
77FLT30.55340365
78ARAF0.55083117
79ABL20.54790642
80OXSR10.53673983
81PASK0.52206056
82OBSCN0.52011635
83ATM0.51310695
84ILK0.50249487
85WNK40.50243147
86TGFBR10.44513169
87RPS6KA40.43589982
88MAPKAPK50.41580672
89CHEK10.40955126
90CDK70.39948279
91STK30.38999874
92MAPK150.37301213
93PRKCG0.35802839
94PHKG10.35062870
95PHKG20.35062870
96ADRBK10.35047857
97MAPK130.35021925
98DAPK30.34845822
99PAK40.33022496
100PAK10.32168266

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.34211199
2Oxidative phosphorylation_Homo sapiens_hsa001903.98745513
3Ribosome_Homo sapiens_hsa030103.44282149
4Parkinsons disease_Homo sapiens_hsa050123.43195184
5Mismatch repair_Homo sapiens_hsa034302.95769930
6DNA replication_Homo sapiens_hsa030302.84718489
7Protein export_Homo sapiens_hsa030602.77179749
8RNA polymerase_Homo sapiens_hsa030202.71625215
9Homologous recombination_Homo sapiens_hsa034402.60189020
10Huntingtons disease_Homo sapiens_hsa050162.49901046
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37845706
12Alzheimers disease_Homo sapiens_hsa050102.22618904
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.96042622
14Nucleotide excision repair_Homo sapiens_hsa034201.94894918
15Base excision repair_Homo sapiens_hsa034101.87517402
16Fanconi anemia pathway_Homo sapiens_hsa034601.85306562
17Pyrimidine metabolism_Homo sapiens_hsa002401.69383482
18Spliceosome_Homo sapiens_hsa030401.67992214
19Basal transcription factors_Homo sapiens_hsa030221.67049435
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.65861652
21One carbon pool by folate_Homo sapiens_hsa006701.63216856
22Propanoate metabolism_Homo sapiens_hsa006401.61605798
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.58843108
24Fatty acid elongation_Homo sapiens_hsa000621.58176320
25RNA degradation_Homo sapiens_hsa030181.56970638
26Non-homologous end-joining_Homo sapiens_hsa034501.54785503
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51294872
28RNA transport_Homo sapiens_hsa030131.49709358
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.48012019
30Cardiac muscle contraction_Homo sapiens_hsa042601.46611412
31Pyruvate metabolism_Homo sapiens_hsa006201.43932432
32Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.43567276
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.40348518
34Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.34514806
35Folate biosynthesis_Homo sapiens_hsa007901.33055800
36Purine metabolism_Homo sapiens_hsa002301.26676843
37Glutathione metabolism_Homo sapiens_hsa004801.20250239
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.19921152
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.19558952
40Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12528325
41Butanoate metabolism_Homo sapiens_hsa006501.09759867
42Cell cycle_Homo sapiens_hsa041101.02296386
43Sulfur metabolism_Homo sapiens_hsa009200.98945932
44Peroxisome_Homo sapiens_hsa041460.97687282
45Sulfur relay system_Homo sapiens_hsa041220.95907678
46Metabolic pathways_Homo sapiens_hsa011000.88067924
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.85868491
48Selenocompound metabolism_Homo sapiens_hsa004500.83637082
49Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.83343590
50Carbon metabolism_Homo sapiens_hsa012000.83224651
51Vitamin B6 metabolism_Homo sapiens_hsa007500.73122217
52Steroid biosynthesis_Homo sapiens_hsa001000.72405006
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.72312561
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71049395
55Nitrogen metabolism_Homo sapiens_hsa009100.68399373
56Tryptophan metabolism_Homo sapiens_hsa003800.68340864
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67535899
58Collecting duct acid secretion_Homo sapiens_hsa049660.66490492
59Phototransduction_Homo sapiens_hsa047440.65692184
60Chemical carcinogenesis_Homo sapiens_hsa052040.65641656
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.64770325
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63177316
63Biosynthesis of amino acids_Homo sapiens_hsa012300.62816974
64Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62773341
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.60775957
66Fatty acid degradation_Homo sapiens_hsa000710.59772239
67Maturity onset diabetes of the young_Homo sapiens_hsa049500.59383363
68Fatty acid metabolism_Homo sapiens_hsa012120.59150128
69Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58103364
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55376147
71Oocyte meiosis_Homo sapiens_hsa041140.54520185
72beta-Alanine metabolism_Homo sapiens_hsa004100.52430784
73N-Glycan biosynthesis_Homo sapiens_hsa005100.52339460
74Drug metabolism - other enzymes_Homo sapiens_hsa009830.51773311
75Regulation of autophagy_Homo sapiens_hsa041400.49264713
76Caffeine metabolism_Homo sapiens_hsa002320.46357442
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44902632
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44210551
79Tyrosine metabolism_Homo sapiens_hsa003500.43753975
80Systemic lupus erythematosus_Homo sapiens_hsa053220.43326744
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.41412701
82Retinol metabolism_Homo sapiens_hsa008300.40457301
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.38843005
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.36379872
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.34144974
86mRNA surveillance pathway_Homo sapiens_hsa030150.33298305
87Arginine and proline metabolism_Homo sapiens_hsa003300.32898955
88p53 signaling pathway_Homo sapiens_hsa041150.31466217
89Linoleic acid metabolism_Homo sapiens_hsa005910.31073075
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28588400
91Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.22191639
92Vitamin digestion and absorption_Homo sapiens_hsa049770.21419761
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.21173299
94Pentose phosphate pathway_Homo sapiens_hsa000300.20499153
95alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.19773679
96Asthma_Homo sapiens_hsa053100.18500386
97Olfactory transduction_Homo sapiens_hsa047400.17977661
98Fat digestion and absorption_Homo sapiens_hsa049750.17513725
99Arachidonic acid metabolism_Homo sapiens_hsa005900.17302416
100Epstein-Barr virus infection_Homo sapiens_hsa051690.17141344

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »