

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.34935259 |
| 2 | proteasome assembly (GO:0043248) | 5.64677963 |
| 3 | ATP synthesis coupled proton transport (GO:0015986) | 5.55971862 |
| 4 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.55971862 |
| 5 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 4.98534824 |
| 6 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 4.83478580 |
| 7 | respiratory electron transport chain (GO:0022904) | 4.73791870 |
| 8 | electron transport chain (GO:0022900) | 4.66372376 |
| 9 | protein complex biogenesis (GO:0070271) | 4.37110599 |
| 10 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 4.31415425 |
| 11 | chaperone-mediated protein transport (GO:0072321) | 4.30840536 |
| 12 | mitochondrial respiratory chain complex assembly (GO:0033108) | 4.24975217 |
| 13 | regulation of mitochondrial translation (GO:0070129) | 4.13983846 |
| 14 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 4.05643244 |
| 15 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 4.04973186 |
| 16 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 4.02432139 |
| 17 | NADH dehydrogenase complex assembly (GO:0010257) | 4.02432139 |
| 18 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 4.02432139 |
| 19 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.94024292 |
| 20 | CENP-A containing nucleosome assembly (GO:0034080) | 3.91672165 |
| 21 | respiratory chain complex IV assembly (GO:0008535) | 3.91644124 |
| 22 | cullin deneddylation (GO:0010388) | 3.88774472 |
| 23 | negative regulation of ligase activity (GO:0051352) | 3.88717853 |
| 24 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.88717853 |
| 25 | chromatin remodeling at centromere (GO:0031055) | 3.88021561 |
| 26 | protein neddylation (GO:0045116) | 3.79029638 |
| 27 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.76408445 |
| 28 | ribosomal small subunit assembly (GO:0000028) | 3.72241473 |
| 29 | cytochrome complex assembly (GO:0017004) | 3.66619865 |
| 30 | establishment of integrated proviral latency (GO:0075713) | 3.65150569 |
| 31 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 3.64300233 |
| 32 | termination of RNA polymerase III transcription (GO:0006386) | 3.64300233 |
| 33 | protein deneddylation (GO:0000338) | 3.64050304 |
| 34 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.63657961 |
| 35 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.62267634 |
| 36 | rRNA modification (GO:0000154) | 3.62200200 |
| 37 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.59175435 |
| 38 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.57725059 |
| 39 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.57725059 |
| 40 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.57725059 |
| 41 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.55859526 |
| 42 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.55859526 |
| 43 | oxidative phosphorylation (GO:0006119) | 3.54343168 |
| 44 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.54311942 |
| 45 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.54311942 |
| 46 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.51111708 |
| 47 | protein targeting to mitochondrion (GO:0006626) | 3.48512299 |
| 48 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.43373047 |
| 49 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.43373047 |
| 50 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39729758 |
| 51 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.38793224 |
| 52 | positive regulation of ligase activity (GO:0051351) | 3.37278815 |
| 53 | pseudouridine synthesis (GO:0001522) | 3.29980273 |
| 54 | ATP biosynthetic process (GO:0006754) | 3.29593317 |
| 55 | ribosomal large subunit biogenesis (GO:0042273) | 3.27845524 |
| 56 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.26262668 |
| 57 | protein localization to mitochondrion (GO:0070585) | 3.25955715 |
| 58 | establishment of protein localization to mitochondrion (GO:0072655) | 3.25830663 |
| 59 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.25159396 |
| 60 | cotranslational protein targeting to membrane (GO:0006613) | 3.23991695 |
| 61 | histone exchange (GO:0043486) | 3.22564382 |
| 62 | translation (GO:0006412) | 3.21613994 |
| 63 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.20732774 |
| 64 | protein targeting to ER (GO:0045047) | 3.17520788 |
| 65 | spliceosomal snRNP assembly (GO:0000387) | 3.15338511 |
| 66 | translational termination (GO:0006415) | 3.14568882 |
| 67 | viral transcription (GO:0019083) | 3.13432642 |
| 68 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.11342561 |
| 69 | DNA strand elongation involved in DNA replication (GO:0006271) | 3.10488664 |
| 70 | DNA replication checkpoint (GO:0000076) | 3.06768257 |
| 71 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.05287546 |
| 72 | protein localization to endoplasmic reticulum (GO:0070972) | 3.05174777 |
| 73 | regulation of mitotic spindle checkpoint (GO:1903504) | 3.04055335 |
| 74 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 3.04055335 |
| 75 | DNA deamination (GO:0045006) | 3.03000931 |
| 76 | protein-cofactor linkage (GO:0018065) | 3.02695558 |
| 77 | hydrogen ion transmembrane transport (GO:1902600) | 3.02132202 |
| 78 | regulation of ligase activity (GO:0051340) | 3.01436510 |
| 79 | inner mitochondrial membrane organization (GO:0007007) | 2.99539444 |
| 80 | purine nucleobase biosynthetic process (GO:0009113) | 2.95325363 |
| 81 | DNA strand elongation (GO:0022616) | 2.95284382 |
| 82 | cellular component biogenesis (GO:0044085) | 2.95199984 |
| 83 | establishment of viral latency (GO:0019043) | 2.95181361 |
| 84 | rRNA methylation (GO:0031167) | 2.93046611 |
| 85 | GTP biosynthetic process (GO:0006183) | 2.92674389 |
| 86 | mitochondrial transport (GO:0006839) | 2.92383742 |
| 87 | transcription-coupled nucleotide-excision repair (GO:0006283) | 2.91923355 |
| 88 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.91488716 |
| 89 | telomere maintenance via recombination (GO:0000722) | 2.90922140 |
| 90 | DNA double-strand break processing (GO:0000729) | 2.90177091 |
| 91 | ribonucleoside triphosphate biosynthetic process (GO:0009201) | 2.90017209 |
| 92 | maturation of SSU-rRNA (GO:0030490) | 2.85193556 |
| 93 | DNA damage response, detection of DNA damage (GO:0042769) | 2.84457034 |
| 94 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.84305878 |
| 95 | rRNA processing (GO:0006364) | 2.83804245 |
| 96 | translational initiation (GO:0006413) | 2.82353380 |
| 97 | DNA replication-independent nucleosome organization (GO:0034724) | 2.80918343 |
| 98 | DNA replication-independent nucleosome assembly (GO:0006336) | 2.80918343 |
| 99 | mitotic recombination (GO:0006312) | 2.80859373 |
| 100 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 2.80761993 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 5.39912076 |
| 2 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 4.69846532 |
| 3 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 4.29342471 |
| 4 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 4.18817785 |
| 5 | E2F7_22180533_ChIP-Seq_HELA_Human | 4.02198631 |
| 6 | JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.58096730 |
| 7 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 3.37668292 |
| 8 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.34285928 |
| 9 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.24693774 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.15598223 |
| 11 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 3.14783434 |
| 12 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 3.06043648 |
| 13 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.03354981 |
| 14 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.89458482 |
| 15 | * VDR_23849224_ChIP-Seq_CD4+_Human | 2.70996297 |
| 16 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 2.67122640 |
| 17 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 2.52249077 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.52093890 |
| 19 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.49494783 |
| 20 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.47856848 |
| 21 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.43376202 |
| 22 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.42206124 |
| 23 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.27961879 |
| 24 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.19315839 |
| 25 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.16173790 |
| 26 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.12185074 |
| 27 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.09655646 |
| 28 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.07076891 |
| 29 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 2.04269247 |
| 30 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.02871715 |
| 31 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 2.01964213 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.97986681 |
| 33 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 1.96901350 |
| 34 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.89424180 |
| 35 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 1.87518419 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 1.86815074 |
| 37 | * PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.85318426 |
| 38 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.77994989 |
| 39 | XRN2_22483619_ChIP-Seq_HELA_Human | 1.76149456 |
| 40 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.74365838 |
| 41 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.61862645 |
| 42 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.60805430 |
| 43 | VDR_22108803_ChIP-Seq_LS180_Human | 1.60578475 |
| 44 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.58193269 |
| 45 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.53972638 |
| 46 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.52452118 |
| 47 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.52418748 |
| 48 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.46557180 |
| 49 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.42860677 |
| 50 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.39999659 |
| 51 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.38952619 |
| 52 | EWS_26573619_Chip-Seq_HEK293_Human | 1.38445603 |
| 53 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.30980565 |
| 54 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.29596558 |
| 55 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.29161472 |
| 56 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.28574806 |
| 57 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 1.25923897 |
| 58 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.23823818 |
| 59 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.23782478 |
| 60 | FUS_26573619_Chip-Seq_HEK293_Human | 1.23159411 |
| 61 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.20332744 |
| 62 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.19567008 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.15517910 |
| 64 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.08773943 |
| 65 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.05572004 |
| 66 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.04078767 |
| 67 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.02426702 |
| 68 | * CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 1.01978460 |
| 69 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.01496259 |
| 70 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01043473 |
| 71 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.99072636 |
| 72 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97574328 |
| 73 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.97523277 |
| 74 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 0.94925546 |
| 75 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 0.93387944 |
| 76 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.93107914 |
| 77 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 0.92963515 |
| 78 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.92699966 |
| 79 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.90494920 |
| 80 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 0.88965909 |
| 81 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 0.88727319 |
| 82 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 0.87498041 |
| 83 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 0.87314128 |
| 84 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.85858790 |
| 85 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.84223129 |
| 86 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.81843363 |
| 87 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 0.80060548 |
| 88 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.80031143 |
| 89 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.79321678 |
| 90 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.79321678 |
| 91 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.76802510 |
| 92 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.76645908 |
| 93 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.74152131 |
| 94 | AR_20517297_ChIP-Seq_VCAP_Human | 0.73848794 |
| 95 | P300_19829295_ChIP-Seq_ESCs_Human | 0.72110106 |
| 96 | PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse | 0.71013812 |
| 97 | * PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.70970778 |
| 98 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.70847217 |
| 99 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.70665662 |
| 100 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.70106881 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0008058_abnormal_DNA_repair | 3.93553032 |
| 2 | MP0003806_abnormal_nucleotide_metabolis | 3.48685981 |
| 3 | MP0003693_abnormal_embryo_hatching | 3.36156796 |
| 4 | MP0004147_increased_porphyrin_level | 3.24953842 |
| 5 | MP0010094_abnormal_chromosome_stability | 3.18847798 |
| 6 | MP0003718_maternal_effect | 2.89284839 |
| 7 | MP0003186_abnormal_redox_activity | 2.87813453 |
| 8 | MP0000372_irregular_coat_pigmentation | 2.80900077 |
| 9 | MP0004957_abnormal_blastocyst_morpholog | 2.72932264 |
| 10 | MP0006036_abnormal_mitochondrial_physio | 2.61924782 |
| 11 | MP0006292_abnormal_olfactory_placode | 2.49762579 |
| 12 | MP0008877_abnormal_DNA_methylation | 2.39163200 |
| 13 | MP0009697_abnormal_copulation | 2.33251111 |
| 14 | MP0003111_abnormal_nucleus_morphology | 2.31630352 |
| 15 | MP0003077_abnormal_cell_cycle | 2.24971287 |
| 16 | MP0003786_premature_aging | 2.20072996 |
| 17 | MP0006072_abnormal_retinal_apoptosis | 2.16162458 |
| 18 | MP0003136_yellow_coat_color | 2.12862357 |
| 19 | MP0001529_abnormal_vocalization | 2.10796863 |
| 20 | MP0008932_abnormal_embryonic_tissue | 2.07665654 |
| 21 | MP0002938_white_spotting | 2.01446945 |
| 22 | MP0002102_abnormal_ear_morphology | 1.99855115 |
| 23 | MP0006035_abnormal_mitochondrial_morpho | 1.96733957 |
| 24 | MP0008057_abnormal_DNA_replication | 1.85887278 |
| 25 | MP0005084_abnormal_gallbladder_morpholo | 1.84895732 |
| 26 | MP0008007_abnormal_cellular_replicative | 1.80602876 |
| 27 | MP0002837_dystrophic_cardiac_calcinosis | 1.75474819 |
| 28 | MP0009379_abnormal_foot_pigmentation | 1.70368789 |
| 29 | MP0008789_abnormal_olfactory_epithelium | 1.68373697 |
| 30 | MP0008875_abnormal_xenobiotic_pharmacok | 1.61621433 |
| 31 | MP0008995_early_reproductive_senescence | 1.61337245 |
| 32 | MP0005075_abnormal_melanosome_morpholog | 1.57631638 |
| 33 | MP0003195_calcinosis | 1.57399370 |
| 34 | MP0005408_hypopigmentation | 1.56374226 |
| 35 | MP0001293_anophthalmia | 1.54134328 |
| 36 | MP0001764_abnormal_homeostasis | 1.49336514 |
| 37 | MP0001984_abnormal_olfaction | 1.47362099 |
| 38 | MP0002736_abnormal_nociception_after | 1.42290839 |
| 39 | MP0010030_abnormal_orbit_morphology | 1.40291711 |
| 40 | MP0005253_abnormal_eye_physiology | 1.33730709 |
| 41 | MP0003011_delayed_dark_adaptation | 1.29900193 |
| 42 | MP0002210_abnormal_sex_determination | 1.29670071 |
| 43 | MP0003890_abnormal_embryonic-extraembry | 1.28038439 |
| 44 | MP0001929_abnormal_gametogenesis | 1.27949720 |
| 45 | MP0000358_abnormal_cell_content/ | 1.25317446 |
| 46 | MP0005551_abnormal_eye_electrophysiolog | 1.25306311 |
| 47 | MP0005394_taste/olfaction_phenotype | 1.20963175 |
| 48 | MP0005499_abnormal_olfactory_system | 1.20963175 |
| 49 | MP0002160_abnormal_reproductive_system | 1.15267602 |
| 50 | MP0002095_abnormal_skin_pigmentation | 1.13416769 |
| 51 | MP0004142_abnormal_muscle_tone | 1.12379048 |
| 52 | MP0008872_abnormal_physiological_respon | 1.10948465 |
| 53 | MP0003567_abnormal_fetal_cardiomyocyte | 1.08430766 |
| 54 | MP0004133_heterotaxia | 1.06390322 |
| 55 | MP0000653_abnormal_sex_gland | 1.04119063 |
| 56 | MP0002638_abnormal_pupillary_reflex | 1.02263300 |
| 57 | MP0004215_abnormal_myocardial_fiber | 1.02114209 |
| 58 | MP0005645_abnormal_hypothalamus_physiol | 1.01635776 |
| 59 | MP0002234_abnormal_pharynx_morphology | 1.01319096 |
| 60 | MP0002653_abnormal_ependyma_morphology | 0.99848023 |
| 61 | MP0005332_abnormal_amino_acid | 0.99801050 |
| 62 | MP0001145_abnormal_male_reproductive | 0.99675558 |
| 63 | MP0002277_abnormal_respiratory_mucosa | 0.98702611 |
| 64 | MP0005410_abnormal_fertilization | 0.96113250 |
| 65 | MP0005636_abnormal_mineral_homeostasis | 0.95079772 |
| 66 | MP0002090_abnormal_vision | 0.93279587 |
| 67 | MP0000647_abnormal_sebaceous_gland | 0.91696489 |
| 68 | MP0004145_abnormal_muscle_electrophysio | 0.91551151 |
| 69 | MP0000631_abnormal_neuroendocrine_gland | 0.90642853 |
| 70 | MP0005389_reproductive_system_phenotype | 0.90141576 |
| 71 | MP0001905_abnormal_dopamine_level | 0.89622852 |
| 72 | MP0009046_muscle_twitch | 0.89089588 |
| 73 | MP0003698_abnormal_male_reproductive | 0.88692341 |
| 74 | MP0003880_abnormal_central_pattern | 0.86049474 |
| 75 | MP0005083_abnormal_biliary_tract | 0.85933244 |
| 76 | MP0003950_abnormal_plasma_membrane | 0.84140564 |
| 77 | MP0002163_abnormal_gland_morphology | 0.84056429 |
| 78 | MP0005395_other_phenotype | 0.83054408 |
| 79 | MP0001968_abnormal_touch/_nociception | 0.82773506 |
| 80 | MP0006276_abnormal_autonomic_nervous | 0.82055783 |
| 81 | MP0003121_genomic_imprinting | 0.81161773 |
| 82 | MP0003646_muscle_fatigue | 0.80426999 |
| 83 | MP0005646_abnormal_pituitary_gland | 0.76729651 |
| 84 | MP0003656_abnormal_erythrocyte_physiolo | 0.76697312 |
| 85 | MP0005379_endocrine/exocrine_gland_phen | 0.76550430 |
| 86 | MP0001697_abnormal_embryo_size | 0.75819276 |
| 87 | MP0003137_abnormal_impulse_conducting | 0.75717107 |
| 88 | MP0001324_abnormal_eye_pigmentation | 0.75239613 |
| 89 | MP0001119_abnormal_female_reproductive | 0.74026447 |
| 90 | MP0000749_muscle_degeneration | 0.73172181 |
| 91 | MP0003937_abnormal_limbs/digits/tail_de | 0.72906349 |
| 92 | MP0001485_abnormal_pinna_reflex | 0.72258532 |
| 93 | MP0000350_abnormal_cell_proliferation | 0.71530028 |
| 94 | MP0005174_abnormal_tail_pigmentation | 0.70819996 |
| 95 | MP0001286_abnormal_eye_development | 0.69919880 |
| 96 | MP0000313_abnormal_cell_death | 0.69070884 |
| 97 | MP0005266_abnormal_metabolism | 0.68307649 |
| 98 | MP0002132_abnormal_respiratory_system | 0.68082072 |
| 99 | MP0002233_abnormal_nose_morphology | 0.67739474 |
| 100 | MP0002751_abnormal_autonomic_nervous | 0.65799523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Acute necrotizing encephalopathy (HP:0006965) | 5.51785615 |
| 2 | Abnormal mitochondria in muscle tissue (HP:0008316) | 5.08887226 |
| 3 | Acute encephalopathy (HP:0006846) | 5.01948081 |
| 4 | Mitochondrial inheritance (HP:0001427) | 4.85249435 |
| 5 | Progressive macrocephaly (HP:0004481) | 4.67640138 |
| 6 | Increased CSF lactate (HP:0002490) | 4.57668530 |
| 7 | Increased hepatocellular lipid droplets (HP:0006565) | 4.34448968 |
| 8 | Hepatocellular necrosis (HP:0001404) | 4.25924394 |
| 9 | Hepatic necrosis (HP:0002605) | 4.14549492 |
| 10 | Lipid accumulation in hepatocytes (HP:0006561) | 4.07485966 |
| 11 | Cerebral edema (HP:0002181) | 3.74451801 |
| 12 | Renal Fanconi syndrome (HP:0001994) | 3.59692085 |
| 13 | Abnormal number of erythroid precursors (HP:0012131) | 3.14274860 |
| 14 | Increased intramyocellular lipid droplets (HP:0012240) | 3.14179104 |
| 15 | Increased serum lactate (HP:0002151) | 3.10799217 |
| 16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.10107179 |
| 17 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.10107179 |
| 18 | Lactic acidosis (HP:0003128) | 3.09692312 |
| 19 | 3-Methylglutaconic aciduria (HP:0003535) | 3.03364078 |
| 20 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.94733965 |
| 21 | Type I transferrin isoform profile (HP:0003642) | 2.93843228 |
| 22 | Respiratory failure (HP:0002878) | 2.88610364 |
| 23 | Exercise intolerance (HP:0003546) | 2.78839824 |
| 24 | Optic disc pallor (HP:0000543) | 2.71771912 |
| 25 | Exertional dyspnea (HP:0002875) | 2.69708339 |
| 26 | Pancreatic cysts (HP:0001737) | 2.65272226 |
| 27 | Increased muscle lipid content (HP:0009058) | 2.64799020 |
| 28 | Pancreatic fibrosis (HP:0100732) | 2.60339845 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.60299020 |
| 30 | Reticulocytopenia (HP:0001896) | 2.53569191 |
| 31 | Increased serum pyruvate (HP:0003542) | 2.49040413 |
| 32 | Lethargy (HP:0001254) | 2.48926964 |
| 33 | Macrocytic anemia (HP:0001972) | 2.47669421 |
| 34 | Leukodystrophy (HP:0002415) | 2.47419113 |
| 35 | Respiratory difficulties (HP:0002880) | 2.45547191 |
| 36 | True hermaphroditism (HP:0010459) | 2.44979364 |
| 37 | Methylmalonic acidemia (HP:0002912) | 2.44395832 |
| 38 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.42824533 |
| 39 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.42824533 |
| 40 | Abnormal protein glycosylation (HP:0012346) | 2.42824533 |
| 41 | Abnormal glycosylation (HP:0012345) | 2.42824533 |
| 42 | Molar tooth sign on MRI (HP:0002419) | 2.40629602 |
| 43 | Abnormality of midbrain morphology (HP:0002418) | 2.40629602 |
| 44 | Abnormality of alanine metabolism (HP:0010916) | 2.38377950 |
| 45 | Hyperalaninemia (HP:0003348) | 2.38377950 |
| 46 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.38377950 |
| 47 | Abnormality of renal resorption (HP:0011038) | 2.36226797 |
| 48 | Meckel diverticulum (HP:0002245) | 2.35367393 |
| 49 | Congenital, generalized hypertrichosis (HP:0004540) | 2.30986603 |
| 50 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.29356573 |
| 51 | Methylmalonic aciduria (HP:0012120) | 2.27092468 |
| 52 | Abnormality of the ileum (HP:0001549) | 2.26790075 |
| 53 | Abnormality of methionine metabolism (HP:0010901) | 2.26038089 |
| 54 | Abnormality of glycolysis (HP:0004366) | 2.25871553 |
| 55 | Generalized aminoaciduria (HP:0002909) | 2.23259467 |
| 56 | CNS demyelination (HP:0007305) | 2.21546949 |
| 57 | Abnormality of urine glucose concentration (HP:0011016) | 2.18454267 |
| 58 | Glycosuria (HP:0003076) | 2.18454267 |
| 59 | Degeneration of anterior horn cells (HP:0002398) | 2.17652438 |
| 60 | Abnormality of the anterior horn cell (HP:0006802) | 2.17652438 |
| 61 | Medial flaring of the eyebrow (HP:0010747) | 2.17323684 |
| 62 | Reduced antithrombin III activity (HP:0001976) | 2.15220543 |
| 63 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.14367395 |
| 64 | Colon cancer (HP:0003003) | 2.09698748 |
| 65 | Aplastic anemia (HP:0001915) | 2.08189508 |
| 66 | Abnormality of the preputium (HP:0100587) | 2.07206426 |
| 67 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.06150097 |
| 68 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.02805881 |
| 69 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 2.01658697 |
| 70 | Pancytopenia (HP:0001876) | 1.98826153 |
| 71 | Abnormality of serum amino acid levels (HP:0003112) | 1.97598919 |
| 72 | Abnormality of chromosome stability (HP:0003220) | 1.96192735 |
| 73 | Hyperglycinemia (HP:0002154) | 1.95326734 |
| 74 | Chromsome breakage (HP:0040012) | 1.94576469 |
| 75 | Abnormality of the labia minora (HP:0012880) | 1.94181231 |
| 76 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 1.93107989 |
| 77 | Nephronophthisis (HP:0000090) | 1.92880062 |
| 78 | Sclerocornea (HP:0000647) | 1.87990724 |
| 79 | X-linked dominant inheritance (HP:0001423) | 1.87352289 |
| 80 | Oral leukoplakia (HP:0002745) | 1.86257008 |
| 81 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.85306963 |
| 82 | Dicarboxylic aciduria (HP:0003215) | 1.85306963 |
| 83 | Birth length less than 3rd percentile (HP:0003561) | 1.84713789 |
| 84 | Hypoglycemic coma (HP:0001325) | 1.84232353 |
| 85 | Pallor (HP:0000980) | 1.81722852 |
| 86 | Aplasia/Hypoplasia of the tongue (HP:0010295) | 1.75264286 |
| 87 | Duodenal stenosis (HP:0100867) | 1.74605412 |
| 88 | Small intestinal stenosis (HP:0012848) | 1.74605412 |
| 89 | Hyperphosphaturia (HP:0003109) | 1.72999355 |
| 90 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.71843945 |
| 91 | Triphalangeal thumb (HP:0001199) | 1.71510362 |
| 92 | Nausea (HP:0002018) | 1.71364948 |
| 93 | Absent thumb (HP:0009777) | 1.70864314 |
| 94 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.68872637 |
| 95 | Microvesicular hepatic steatosis (HP:0001414) | 1.67561563 |
| 96 | Congenital primary aphakia (HP:0007707) | 1.67338690 |
| 97 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.67306670 |
| 98 | Renal cortical cysts (HP:0000803) | 1.67074942 |
| 99 | Emotional lability (HP:0000712) | 1.66404315 |
| 100 | Hyperglycinuria (HP:0003108) | 1.65868750 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | VRK2 | 4.41226699 |
| 2 | BUB1 | 3.67366241 |
| 3 | PBK | 2.87000757 |
| 4 | MST4 | 2.83455943 |
| 5 | ZAK | 2.71029570 |
| 6 | STK16 | 2.60147565 |
| 7 | VRK1 | 2.53994412 |
| 8 | EIF2AK1 | 2.48120831 |
| 9 | SRPK1 | 2.36435935 |
| 10 | CDC7 | 2.34684048 |
| 11 | NEK1 | 2.20026460 |
| 12 | NUAK1 | 2.15723469 |
| 13 | NME2 | 2.11092929 |
| 14 | TRIM28 | 2.07170278 |
| 15 | NME1 | 2.05448785 |
| 16 | BMPR1B | 1.91435530 |
| 17 | MAP3K12 | 1.89432088 |
| 18 | PLK4 | 1.83724737 |
| 19 | EIF2AK3 | 1.82703781 |
| 20 | MAP4K2 | 1.82366354 |
| 21 | PLK3 | 1.81609991 |
| 22 | WEE1 | 1.81361919 |
| 23 | TTK | 1.70545960 |
| 24 | PDK2 | 1.66398250 |
| 25 | BCKDK | 1.65587693 |
| 26 | TSSK6 | 1.65240951 |
| 27 | WNK3 | 1.52186358 |
| 28 | TLK1 | 1.50386114 |
| 29 | PLK1 | 1.37214486 |
| 30 | BRSK2 | 1.30137319 |
| 31 | ACVR1B | 1.22661000 |
| 32 | FRK | 1.20983455 |
| 33 | CCNB1 | 1.16680049 |
| 34 | INSRR | 1.04547475 |
| 35 | GRK1 | 1.03806115 |
| 36 | MKNK1 | 1.03162496 |
| 37 | ADRBK2 | 1.02578897 |
| 38 | TAF1 | 0.99613569 |
| 39 | LIMK1 | 0.99586991 |
| 40 | CSNK1G3 | 0.98914818 |
| 41 | AURKB | 0.98346915 |
| 42 | DYRK2 | 0.93697800 |
| 43 | CSNK1G1 | 0.91106200 |
| 44 | ERBB4 | 0.90965334 |
| 45 | MKNK2 | 0.89459370 |
| 46 | TNIK | 0.88738053 |
| 47 | CSNK1G2 | 0.84770305 |
| 48 | CHEK2 | 0.83985908 |
| 49 | BRSK1 | 0.82681682 |
| 50 | ATR | 0.82533235 |
| 51 | TESK2 | 0.82275178 |
| 52 | AURKA | 0.79489240 |
| 53 | MAP2K7 | 0.78821921 |
| 54 | ERBB3 | 0.78742359 |
| 55 | EIF2AK2 | 0.76397532 |
| 56 | TESK1 | 0.73103214 |
| 57 | RPS6KA5 | 0.73101000 |
| 58 | CDK19 | 0.72933072 |
| 59 | DAPK1 | 0.72649315 |
| 60 | STK4 | 0.71189877 |
| 61 | CDK8 | 0.70895030 |
| 62 | PLK2 | 0.70489249 |
| 63 | CSNK1A1L | 0.69634218 |
| 64 | MAP3K4 | 0.68132476 |
| 65 | PIM2 | 0.68093825 |
| 66 | PNCK | 0.67049260 |
| 67 | MUSK | 0.63294497 |
| 68 | PINK1 | 0.62893578 |
| 69 | CSNK2A2 | 0.61945987 |
| 70 | CSNK2A1 | 0.61349846 |
| 71 | NEK2 | 0.61081940 |
| 72 | KDR | 0.60349971 |
| 73 | BCR | 0.60102790 |
| 74 | MYLK | 0.56545621 |
| 75 | SCYL2 | 0.55838555 |
| 76 | PRKCI | 0.55637057 |
| 77 | FLT3 | 0.55340365 |
| 78 | ARAF | 0.55083117 |
| 79 | ABL2 | 0.54790642 |
| 80 | OXSR1 | 0.53673983 |
| 81 | PASK | 0.52206056 |
| 82 | OBSCN | 0.52011635 |
| 83 | ATM | 0.51310695 |
| 84 | ILK | 0.50249487 |
| 85 | WNK4 | 0.50243147 |
| 86 | TGFBR1 | 0.44513169 |
| 87 | RPS6KA4 | 0.43589982 |
| 88 | MAPKAPK5 | 0.41580672 |
| 89 | CHEK1 | 0.40955126 |
| 90 | CDK7 | 0.39948279 |
| 91 | STK3 | 0.38999874 |
| 92 | MAPK15 | 0.37301213 |
| 93 | PRKCG | 0.35802839 |
| 94 | PHKG1 | 0.35062870 |
| 95 | PHKG2 | 0.35062870 |
| 96 | ADRBK1 | 0.35047857 |
| 97 | MAPK13 | 0.35021925 |
| 98 | DAPK3 | 0.34845822 |
| 99 | PAK4 | 0.33022496 |
| 100 | PAK1 | 0.32168266 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.34211199 |
| 2 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 3.98745513 |
| 3 | Ribosome_Homo sapiens_hsa03010 | 3.44282149 |
| 4 | Parkinsons disease_Homo sapiens_hsa05012 | 3.43195184 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 2.95769930 |
| 6 | DNA replication_Homo sapiens_hsa03030 | 2.84718489 |
| 7 | Protein export_Homo sapiens_hsa03060 | 2.77179749 |
| 8 | RNA polymerase_Homo sapiens_hsa03020 | 2.71625215 |
| 9 | Homologous recombination_Homo sapiens_hsa03440 | 2.60189020 |
| 10 | Huntingtons disease_Homo sapiens_hsa05016 | 2.49901046 |
| 11 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 2.37845706 |
| 12 | Alzheimers disease_Homo sapiens_hsa05010 | 2.22618904 |
| 13 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.96042622 |
| 14 | Nucleotide excision repair_Homo sapiens_hsa03420 | 1.94894918 |
| 15 | Base excision repair_Homo sapiens_hsa03410 | 1.87517402 |
| 16 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.85306562 |
| 17 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 1.69383482 |
| 18 | Spliceosome_Homo sapiens_hsa03040 | 1.67992214 |
| 19 | Basal transcription factors_Homo sapiens_hsa03022 | 1.67049435 |
| 20 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.65861652 |
| 21 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.63216856 |
| 22 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.61605798 |
| 23 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.58843108 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.58176320 |
| 25 | RNA degradation_Homo sapiens_hsa03018 | 1.56970638 |
| 26 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.54785503 |
| 27 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 1.51294872 |
| 28 | RNA transport_Homo sapiens_hsa03013 | 1.49709358 |
| 29 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.48012019 |
| 30 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 1.46611412 |
| 31 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.43932432 |
| 32 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.43567276 |
| 33 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.40348518 |
| 34 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.34514806 |
| 35 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.33055800 |
| 36 | Purine metabolism_Homo sapiens_hsa00230 | 1.26676843 |
| 37 | Glutathione metabolism_Homo sapiens_hsa00480 | 1.20250239 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.19921152 |
| 39 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.19558952 |
| 40 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.12528325 |
| 41 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.09759867 |
| 42 | Cell cycle_Homo sapiens_hsa04110 | 1.02296386 |
| 43 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.98945932 |
| 44 | Peroxisome_Homo sapiens_hsa04146 | 0.97687282 |
| 45 | Sulfur relay system_Homo sapiens_hsa04122 | 0.95907678 |
| 46 | Metabolic pathways_Homo sapiens_hsa01100 | 0.88067924 |
| 47 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.85868491 |
| 48 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.83637082 |
| 49 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.83343590 |
| 50 | Carbon metabolism_Homo sapiens_hsa01200 | 0.83224651 |
| 51 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.73122217 |
| 52 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.72405006 |
| 53 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.72312561 |
| 54 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.71049395 |
| 55 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.68399373 |
| 56 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.68340864 |
| 57 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.67535899 |
| 58 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.66490492 |
| 59 | Phototransduction_Homo sapiens_hsa04744 | 0.65692184 |
| 60 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.65641656 |
| 61 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.64770325 |
| 62 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.63177316 |
| 63 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.62816974 |
| 64 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.62773341 |
| 65 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.60775957 |
| 66 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.59772239 |
| 67 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.59383363 |
| 68 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.59150128 |
| 69 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.58103364 |
| 70 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.55376147 |
| 71 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.54520185 |
| 72 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.52430784 |
| 73 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.52339460 |
| 74 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.51773311 |
| 75 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.49264713 |
| 76 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.46357442 |
| 77 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.44902632 |
| 78 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.44210551 |
| 79 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.43753975 |
| 80 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.43326744 |
| 81 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.41412701 |
| 82 | Retinol metabolism_Homo sapiens_hsa00830 | 0.40457301 |
| 83 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.38843005 |
| 84 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.36379872 |
| 85 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.34144974 |
| 86 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.33298305 |
| 87 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.32898955 |
| 88 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.31466217 |
| 89 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.31073075 |
| 90 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.28588400 |
| 91 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.22191639 |
| 92 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21419761 |
| 93 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.21173299 |
| 94 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.20499153 |
| 95 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.19773679 |
| 96 | Asthma_Homo sapiens_hsa05310 | 0.18500386 |
| 97 | Olfactory transduction_Homo sapiens_hsa04740 | 0.17977661 |
| 98 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.17513725 |
| 99 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.17302416 |
| 100 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.17141344 |

